Papers - HIGUCHI Chigusa

Plasma angiotensin-converting enzyme 2 (ACE2) is a marker for renal outcome of diabetic kidney disease (DKD) (U-CARE study 3). Reviewed International journal

Asami Ueno, Yasuhiro Onishi, Koki Mise, Satoshi Yamaguchi, Ayaka Kanno, Ichiro Nojima, Chigusa Higuchi, Haruhito A Uchida, Kenichi Shikata, Satoshi Miyamoto, Atsuko Nakatsuka, Jun Eguchi, Kazuyuki Hida, Akihiro Katayama, Mayu Watanabe, Tatsuaki Nakato, Atsuhito Tone, Sanae Teshigawara, Takashi Matsuoka, Shinji Kamei, Kazutoshi Murakami, Ikki Shimizu, Katsuhito Miyashita, Shinichiro Ando, Tomokazu Nunoue, Jun Wada

BMJ open diabetes research & care   12 ( 3 )   2024.5

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Language：English   Publishing type：Research paper (scientific journal)  

INTRODUCTION: ACE cleaves angiotensin I (Ang I) to angiotensin II (Ang II) inducing vasoconstriction via Ang II type 1 (AT1) receptor, while ACE2 cleaves Ang II to Ang (1-7) causing vasodilatation by acting on the Mas receptor. In diabetic kidney disease (DKD), it is still unclear whether plasma or urine ACE2 levels predict renal outcomes or not. RESEARCH DESIGN AND METHODS: Among 777 participants with diabetes enrolled in the Urinary biomarker for Continuous And Rapid progression of diabetic nEphropathy study, the 296 patients followed up for 9 years were investigated. Plasma and urinary ACE2 levels were measured by the ELISA. The primary end point was a composite of a decrease of estimated glomerular filtration rate (eGFR) by at least 30% from baseline or initiation of hemodialysis or peritoneal dialysis. The secondary end points were a 30% increase or a 30% decrease in albumin-to-creatinine ratio from baseline to 1 year. RESULTS: The cumulative incidence of the renal composite outcome was significantly higher in group 1 with lowest tertile of plasma ACE2 (p=0.040). Group 2 with middle and highest tertile was associated with better renal outcomes in the crude Cox regression model adjusted by age and sex (HR 0.56, 95% CI 0.31 to 0.99, p=0.047). Plasma ACE2 levels demonstrated a significant association with 30% decrease in ACR (OR 1.46, 95% CI 1.044 to 2.035, p=0.027) after adjusting for age, sex, systolic blood pressure, hemoglobin A1c, and eGFR. CONCLUSIONS: Higher baseline plasma ACE2 levels in DKD were protective for development and progression of albuminuria and associated with fewer renal end points, suggesting plasma ACE2 may be used as a prognosis marker of DKD. TRIAL REGISTRATION NUMBER: UMIN000011525.

DOI： 10.1136/bmjdrc-2024-004237

PubMed

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岡山大学におけるHPVワクチン接種希望に関する アンケート調査

樋口 千草, 小川 千加子, 萩谷 英大, 大塚 勇輝, 大塚 文男, 影山 真希, 成田 美香, 岡 香織, 黒木 清美, 河原 宏子, 宮道 力, 岡部 伸幸, 大西 勝, 岩﨑 良章

CAMPUS HEALTH   61 ( 1 )   2024.3

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Authorship：Lead author   Language：Japanese  

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岡山大学における幸福度の検討 ～ダイバーシティに関するアンケートより～

樋口 千草, 片岡 仁美, 中谷 文美, 池谷 航介, 成田 美香, 岡 香織, 黒木 清美, 河原 宏子, 宮道 力, 岡部 伸幸, 大西 勝, 岩﨑 良章

CAMPUS HEALTH   61 ( 1 )   2024.3

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Authorship：Lead author   Language：Japanese  

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Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial Reviewed

N Staplin, R Haynes, PK Judge, C Wanner, JB Green, J Emberson, D Preiss, KJ Mayne, SYA Ng, E Sammons, D Zhu, M Hill, W Stevens, K Wallendszus, S Brenner, AK Cheung, ZH Liu, J Li, LS Hooi, WJ Liu, T Kadowaki, M Nangaku, A Levin, D Cherney, AP Maggioni, R Pontremoli, R Deo, S Goto, X Rossello, KR Tuttle, D Steubl, M Petrini, S Seidi, MJ Landray, C Baigent, WG Herrington, S Abat, R Abd Rahman, R Abdul Cader, MI Abdul Hafidz, MZ Abdul Wahab, NK Abdullah, T Abdul-Samad, M Abe, N Abraham, S Acheampong, P Achiri, JA Acosta, A Adeleke, V Adell, R Adewuyi-Dalton, N Adnan, A Africano, M Agharazii, F Aguilar, A Aguilera, M Ahmad, MK Ahmad, NA Ahmad, NH Ahmad, NI Ahmad, N Ahmad Miswan, H Ahmad Rosdi, I Ahmed, S Ahmed, S Ahmed, J Aiello, A Aitken, R AitSadi, S Aker, S Akimoto, A Akinfolarin, S Akram, F Alberici, C Albert, L Aldrich, M Alegata, L Alexander, S Alfaress, M Alhadj Ali, A Ali, A Ali, R Alicic, A Aliu, R Almaraz, R Almasarwah, J Almeida, A Aloisi, L Al-Rabadi, D Alscher, P Alvarez, B Al-Zeer, M Amat, C Ambrose, H Ammar, Y An, L Andriaccio, K Ansu, A Apostolidi, N Arai, H Araki, S Araki, A Arbi, O Arechiga, S Armstrong, T Arnold, S Aronoff, W Arriaga, J Arroyo, D Arteaga, S Asahara, A Asai, N Asai, S Asano, M Asawa, MF Asmee, F Aucella, M Augustin, A Avery, A Awad, IY Awang, M Awazawa, A Axler, W Ayub, Z Azhari, R Baccaro, C Badin, B Bagwell, E Bahlmann-Kroll, AZ Bahtar, C Baigent, D Bains, H Bajaj, R Baker, E Baldini, B Banas, D Banerjee, S Banno, S Bansal, S Barberi, S Barnes, C Barnini, C Barot, K Barrett, R Barrios, B Bartolomei Mecatti, I Barton, J Barton, W Basily, S Bavanandan, A Baxter, L Becker, S Beddhu, J Beige, S Beigh, S Bell, U Benck, A Beneat, A Bennett, D Bennett, S Benyon, J Berdeprado, T Bergler, A Bergner, M Berry, M Bevilacqua, J Bhairoo, S Bhandari, N Bhandary, A Bhatt, M Bhattarai, M Bhavsar, W Bian, F Bianchini, S Bianco, R Bilous, J Bilton, D Bilucaglia, C Bird, D Birudaraju, M Biscoveanu, C Blake, N Bleakley, K Bocchicchia, S Bodine, R Bodington, S Boedecker, M Bolduc, S Bolton, C Bond, F Boreky, K Boren, R Bouchi, L Bough, D Bovan, C Bowler, L Bowman, N Brar, C Braun, A Breach, M Breitenfeldt, S Brenner, B Brettschneider, A Brewer, G Brewer, V Brindle, E Brioni, C Brown, H Brown, L Brown, R Brown, S Brown, D Browne, K Bruce, M Brueckmann, N Brunskill, M Bryant, M Brzoska, Y Bu, C Buckman, M Budoff, M Bullen, A Burke, S Burnette, C Burston, M Busch, J Bushnell, S Butler, C Büttner, C Byrne, A Caamano, J Cadorna, C Cafiero, M Cagle, J Cai, K Calabrese, C Calvi, B Camilleri, S Camp, D Campbell, R Campbell, H Cao, I Capelli, M Caple, B Caplin, A Cardone, J Carle, V Carnall, M Caroppo, S Carr, G Carraro, M Carson, P Casares, C Castillo, C Castro, B Caudill, V Cejka, M Ceseri, L Cham, A Chamberlain, J Chambers, CBT Chan, JYM Chan, YC Chan, E Chang, E Chang, T Chant, T Chavagnon, P Chellamuthu, F Chen, J Chen, P Chen, TM Chen, Y Chen, Y Chen, C Cheng, H Cheng, MC Cheng, D Cherney, AK Cheung, CH Ching, N Chitalia, R Choksi, C Chukwu, K Chung, G Cianciolo, L Cipressa, S Clark, H Clarke, R Clarke, S Clarke, B Cleveland, E Cole, H Coles, L Condurache, A Connor, K Convery, A Cooper, N Cooper, Z Cooper, L Cooperman, L Cosgrove, P Coutts, A Cowley, R Craik, G Cui, T Cummins, N Dahl, H Dai, L Dajani, A D'Amelio, E Damian, K Damianik, L Danel, C Daniels, T Daniels, S Darbeau, H Darius, T Dasgupta, J Davies, L Davies, A Davis, J Davis, L Davis, R Dayanandan, S Dayi, R Dayrell, L De Nicola, S Debnath, W Deeb, S Degenhardt, K DeGoursey, M Delaney, R Deo, R DeRaad, V Derebail, D Dev, M Devaux, P Dhall, G Dhillon, J Dienes, M Dobre, E Doctolero, V Dodds, D Domingo, D Donaldson, P Donaldson, C Donhauser, V Donley, S Dorestin, S Dorey, T Doulton, D Draganova, K Draxlbauer, F Driver, H Du, F Dube, T Duck, T Dugal, J Dugas, H Dukka, H Dumann, W Durham, M Dursch, R Dykas, R Easow, E Eckrich, G Eden, E Edmerson, H Edwards, LW Ee, J Eguchi, Y Ehrl, K Eichstadt, W Eid, B Eilerman, Y Ejima, H Eldon, T Ellam, L Elliott, R Ellison, J Emberson, R Epp, A Er, M Espino-Obrero, S Estcourt, L Estienne, G Evans, J Evans, S Evans, G Fabbri, M Fajardo-Moser, C Falcone, F Fani, P Faria-Shayler, F Farnia, D Farrugia, M Fechter, D Fellowes, F Feng, J Fernandez, P Ferraro, A Field, S Fikry, J Finch, H Finn, P Fioretto, R Fish, A Fleischer, D Fleming-Brown, L Fletcher, R Flora, C Foellinger, N Foligno, S Forest, Z Forghani, K Forsyth, D Fottrell-Gould, P Fox, A Frankel, D Fraser, R Frazier, K Frederick, N Freking, H French, A Froment, B Fuchs, L Fuessl, H Fujii, A Fujimoto, A Fujita, K Fujita, Y Fujita, M Fukagawa, Y Fukao, A Fukasawa, T Fuller, T Funayama, E Fung, M Furukawa, Y Furukawa, M Furusho, S Gabel, J Gaidu, S Gaiser, K Gallo, C Galloway, G Gambaro, CC Gan, C Gangemi, M Gao, K Garcia, M Garcia, C Garofalo, M Garrity, A Garza, S Gasko, M Gavrila, B Gebeyehu, A Geddes, G Gentile, A George, J George, L Gesualdo, F Ghalli, A Ghanem, T Ghate, S Ghavampour, A Ghazi, A Gherman, U Giebeln-Hudnell, B Gill, S Gillham, I Girakossyan, M Girndt, A Giuffrida, M Glenwright, T Glider, R Gloria, D Glowski, BL Goh, CB Goh, T Gohda, R Goldenberg, R Goldfaden, C Goldsmith, B Golson, V Gonce, Q Gong, B Goodenough, N Goodwin, M Goonasekera, A Gordon, J Gordon, A Gore, H Goto, S Goto, S Goto, D Gowen, A Grace, J Graham, G Grandaliano, M Gray, JB Green, T Greene, G Greenwood, B Grewal, R Grifa, D Griffin, S Griffin, P Grimmer, E Grobovaite, S Grotjahn, A Guerini, C Guest, S Gunda, B Guo, Q Guo, S Haack, M Haase, K Haaser, K Habuki, A Hadley, S Hagan, S Hagge, H Haller, S Ham, S Hamal, Y Hamamoto, N Hamano, M Hamm, A Hanburry, M Haneda, C Hanf, W Hanif, J Hansen, L Hanson, S Hantel, T Haraguchi, E Harding, T Harding, C Hardy, C Hartner, Z Harun, L Harvill, A Hasan, H Hase, F Hasegawa, T Hasegawa, A Hashimoto, C Hashimoto, M Hashimoto, S Hashimoto, S Haskett, SJ Hauske, A Hawfield, T Hayami, M Hayashi, S Hayashi, R Haynes, A Hazara, C Healy, J Hecktman, G Heine, H Henderson, R Henschel, A Hepditch, K Herfurth, G Hernandez, A Hernandez Pena, C Hernandez-Cassis, WG Herrington, C Herzog, S Hewins, D Hewitt, L Hichkad, S Higashi, C Higuchi, C Hill, L Hill, M Hill, T Himeno, A Hing, Y Hirakawa, K Hirata, Y Hirota, T Hisatake, S Hitchcock, A Hodakowski, W Hodge, R Hogan, U Hohenstatt, B Hohenstein, L Hooi, S Hope, M Hopley, S Horikawa, D Hosein, T Hosooka, L Hou, W Hou, L Howie, A Howson, M Hozak, Z Htet, X Hu, Y Hu, J Huang, N Huda, L Hudig, A Hudson, C Hugo, R Hull, L Hume, W Hundei, N Hunt, A Hunter, S Hurley, A Hurst, C Hutchinson, T Hyo, FH Ibrahim, S Ibrahim, N Ihana, T Ikeda, A Imai, R Imamine, A Inamori, H Inazawa, J Ingell, K Inomata, Y Inukai, M Ioka, A Irtiza-Ali, T Isakova, W Isari, M Iselt, A Ishiguro, K Ishihara, T Ishikawa, T Ishimoto, K Ishizuka, R Ismail, S Itano, H Ito, K Ito, M Ito, Y Ito, S Iwagaitsu, Y Iwaita, T Iwakura, M Iwamoto, M Iwasa, H Iwasaki, S Iwasaki, K Izumi, K Izumi, T Izumi, SM Jaafar, C Jackson, Y Jackson, G Jafari, M Jahangiriesmaili, N Jain, K Jansson, H Jasim, L Jeffers, A Jenkins, M Jesky, J Jesus-Silva, D Jeyarajah, Y Jiang, X Jiao, G Jimenez, B Jin, Q Jin, J Jochims, B Johns, C Johnson, T Johnson, S Jolly, L Jones, L Jones, S Jones, T Jones, V Jones, M Joseph, S Joshi, P Judge, N Junejo, S Junus, M Kachele, T Kadowaki, H Kadoya, H Kaga, H Kai, H Kajio, W Kaluza-Schilling, L Kamaruzaman, A Kamarzarian, Y Kamimura, H Kamiya, C Kamundi, T Kan, Y Kanaguchi, A Kanazawa, E Kanda, S Kanegae, K Kaneko, K Kaneko, HY Kang, T Kano, M Karim, D Karounos, W Karsan, R Kasagi, N Kashihara, H Katagiri, A Katanosaka, A Katayama, M Katayama, E Katiman, K Kato, M Kato, N Kato, S Kato, T Kato, Y Kato, Y Katsuda, T Katsuno, J Kaufeld, Y Kavak, I Kawai, M Kawai, M Kawai, A Kawase, S Kawashima, A Kazory, J Kearney, B Keith, J Kellett, S Kelley, M Kershaw, M Ketteler, Q Khai, Q Khairullah, H Khandwala, KKL Khoo, A Khwaja, K Kidokoro, J Kielstein, M Kihara, C Kimber, S Kimura, H Kinashi, H Kingston, M Kinomura, E Kinsella-Perks, M Kitagawa, M Kitajima, S Kitamura, A Kiyosue, M Kiyota, F Klauser, G Klausmann, W Kmietschak, K Knapp, C Knight, A Knoppe, C Knott, M Kobayashi, R Kobayashi, T Kobayashi, M Koch, S Kodama, N Kodani, E Kogure, M Koizumi, H Kojima, T Kojo, N Kolhe, H Komaba, T Komiya, H Komori, SP Kon, M Kondo, M Kondo, W Kong, M Konishi, K Kono, M Koshino, T Kosugi, B Kothapalli, T Kozlowski, B Kraemer, A Kraemer-Guth, J Krappe, D Kraus, C Kriatselis, C Krieger, P Krish, B Kruger, KR Ku Md Razi, Y Kuan, S Kubota, S Kuhn, P Kumar, S Kume, I Kummer, R Kumuji, A Küpper, T Kuramae, L Kurian, C Kuribayashi, R Kurien, E Kuroda, T Kurose, A Kutschat, N Kuwabara, H Kuwata, G La Manna, M Lacey, K Lafferty, P LaFleur, V Lai, E Laity, A Lambert, MJ Landray, M Langlois, F Latif, E Latore, E Laundy, D Laurienti, A Lawson, M Lay, I Leal, I Leal, AK Lee, J Lee, KQ Lee, R Lee, SA Lee, YY Lee, Y Lee-Barkey, N Leonard, G Leoncini, CM Leong, S Lerario, A Leslie, A Levin, A Lewington, J Li, N Li, X Li, Y Li, L Liberti, ME Liberti, A Liew, YF Liew, U Lilavivat, SK Lim, YS Lim, E Limon, H Lin, E Lioudaki, H Liu, J Liu, L Liu, Q Liu, WJ Liu, X Liu, Z Liu, D Loader, H Lochhead, CL Loh, A Lorimer, L Loudermilk, J Loutan, CK Low, CL Low, YM Low, Z Lozon, Y Lu, D Lucci, U Ludwig, N Luker, D Lund, R Lustig, S Lyle, C Macdonald, I MacDougall, R Machicado, D MacLean, P Macleod, A Madera, F Madore, K Maeda, H Maegawa, S Maeno, M Mafham, J Magee, AP Maggioni, DY Mah, V Mahabadi, M Maiguma, Y Makita, G Makos, L Manco, R Mangiacapra, J Manley, P Mann, S Mano, G Marcotte, J Maris, P Mark, S Markau, M Markovic, C Marshall, M Martin, C Martinez, S Martinez, G Martins, K Maruyama, S Maruyama, K Marx, A Maselli, A Masengu, A Maskill, S Masumoto, K Masutani, M Matsumoto, T Matsunaga, N Matsuoka, M Matsushita, M Matthews, S Matthias, E Matvienko, M Maurer, P Maxwell, KJ Mayne, N Mazlan, SA Mazlan, A Mbuyisa, K McCafferty, F McCarroll, T McCarthy, C McClary-Wright, K McCray, P McDermott, C McDonald, R McDougall, E McHaffie, K McIntosh, T McKinley, S McLaughlin, N McLean, L McNeil, A Measor, J Meek, A Mehta, R Mehta, M Melandri, P Mené, T Meng, J Menne, K Merritt, S Merscher, C Meshykhi, P Messa, L Messinger, N Miftari, R Miller, Y Miller, E Miller-Hodges, M Minatoguchi, M Miners, R Minutolo, T Mita, Y Miura, M Miyaji, S Miyamoto, T Miyatsuka, M Miyazaki, I Miyazawa, R Mizumachi, M Mizuno, S Moffat, FS Mohamad Nor, SN Mohamad Zaini, FA Mohamed Affandi, C Mohandas, R Mohd, NA Mohd Fauzi, NH Mohd Sharif, Y Mohd Yusoff, L Moist, A Moncada, M Montasser, A Moon, C Moran, N Morgan, J Moriarty, G Morig, H Morinaga, K Morino, T Morisaki, Y Morishita, S Morlok, A Morris, F Morris, S Mostafa, Y Mostefai, M Motegi, N Motherwell, D Motta, A Mottl, R Moys, S Mozaffari, J Muir, J Mulhern, S Mulligan, Y Munakata, C Murakami, M Murakoshi, A Murawska, K Murphy, L Murphy, S Murray, H Murtagh, MA Musa, L Mushahar, R Mustafa, R Mustafar, M Muto, E Nadar, R Nagano, T Nagasawa, E Nagashima, H Nagasu, S Nagelberg, H Nair, Y Nakagawa, M Nakahara, J Nakamura, R Nakamura, T Nakamura, M Nakaoka, E Nakashima, J Nakata, M Nakata, S Nakatani, A Nakatsuka, Y Nakayama, G Nakhoul, M Nangaku, G Naverrete, A Navivala, I Nazeer, L Negrea, C Nethaji, E Newman, SYA Ng, TJ Ng, LLS Ngu, T Nimbkar, H Nishi, M Nishi, S Nishi, Y Nishida, A Nishiyama, J Niu, P Niu, G Nobili, N Nohara, I Nojima, J Nolan, H Nosseir, M Nozawa, M Nunn, S Nunokawa, M Oda, M Oe, Y Oe, K Ogane, W Ogawa, T Ogihara, G Oguchi, M Ohsugi, K Oishi, Y Okada, J Okajyo, S Okamoto, K Okamura, O Olufuwa, R Oluyombo, A Omata, Y Omori, LM Ong, YC Ong, J Onyema, A Oomatia, A Oommen, R Oremus, Y Orimo, V Ortalda, Y Osaki, Y Osawa, J Osmond Foster, A O'Sullivan, T Otani, N Othman, S Otomo, J O'Toole, L Owen, T Ozawa, A Padiyar, N Page, S Pajak, A Paliege, A Pandey, R Pandey, H Pariani, J Park, M Parrigon, J Passauer, M Patecki, M Patel, R Patel, T Patel, Z Patel, R Paul, R Paul, L Paulsen, L Pavone, A Peixoto, J Peji, BC Peng, K Peng, L Pennino, E Pereira, E Perez, P Pergola, F Pesce, G Pessolano, W Petchey, EJ Petr, T Pfab, P Phelan, R Phillips, T Phillips, M Phipps, G Piccinni, T Pickett, S Pickworth, M Piemontese, D Pinto, J Piper, J Plummer-Morgan, D Poehler, L Polese, V Poma, R Pontremoli, A Postal, C Pötz, A Power, N Pradhan, R Pradhan, D Preiss, E Preiss, K Preston, N Prib, L Price, C Provenzano, C Pugay, R Pulido, F Putz, Y Qiao, R Quartagno, M Quashie-Akponeware, R Rabara, R Rabasa-Lhoret, D Radhakrishnan, M Radley, R Raff, S Raguwaran, F Rahbari-Oskoui, M Rahman, K Rahmat, S Ramadoss, S Ramanaidu, S Ramasamy, R Ramli, S Ramli, T Ramsey, A Rankin, A Rashidi, L Raymond, WAFA Razali, K Read, H Reiner, A Reisler, C Reith, J Renner, B Rettenmaier, L Richmond, D Rijos, R Rivera, V Rivers, H Robinson, M Rocco, I Rodriguez-Bachiller, R Rodriquez, C Roesch, J Roesch, J Rogers, M Rohnstock, S Rolfsmeier, M Roman, A Romo, A Rosati, S Rosenberg, T Ross, X Rossello, M Roura, M Roussel, S Rovner, S Roy, S Rucker, L Rump, M Ruocco, S Ruse, F Russo, M Russo, M Ryder, A Sabarai, C Saccà, R Sachson, E Sadler, NS Safiee, M Sahani, A Saillant, J Saini, C Saito, S Saito, K Sakaguchi, M Sakai, H Salim, C Salviani, E Sammons, A Sampson, F Samson, P Sandercock, S Sanguila, G Santorelli, D Santoro, N Sarabu, T Saram, R Sardell, H Sasajima, T Sasaki, S Satko, A Sato, D Sato, H Sato, H Sato, J Sato, T Sato, Y Sato, M Satoh, K Sawada, M Schanz, F Scheidemantel, M Schemmelmann, E Schettler, V Schettler, GR Schlieper, C Schmidt, G Schmidt, U Schmidt, H Schmidt-Gurtler, M Schmude, A Schneider, I Schneider, C Schneider-Danwitz, M Schomig, T Schramm, A Schreiber, S Schricker, B Schroppel, L Schulte-Kemna, E Schulz, B Schumacher, A Schuster, A Schwab, F Scolari, A Scott, W Seeger, W Seeger, M Segal, L Seifert, M Seifert, M Sekiya, R Sellars, MR Seman, S Shah, S Shah, L Shainberg, M Shanmuganathan, F Shao, K Sharma, C Sharpe, M Sheikh-Ali, J Sheldon, C Shenton, A Shepherd, M Shepperd, R Sheridan, Z Sheriff, Y Shibata, T Shigehara, K Shikata, K Shimamura, H Shimano, Y Shimizu, H Shimoda, K Shin, G Shivashankar, N Shojima, R Silva, CSB Sim, K Simmons, S Sinha, T Sitter, S Sivanandam, M Skipper, K Sloan, L Sloan, R Smith, J Smyth, T Sobande, M Sobata, S Somalanka, X Song, F Sonntag, B Sood, SY Sor, J Soufer, H Sparks, G Spatoliatore, T Spinola, S Squyres, A Srivastava, J Stanfield, N Staplin, K Staylor, A Steele, O Steen, D Steffl, J Stegbauer, C Stellbrink, E Stellbrink, W Stevens, A Stevenson, V Stewart-Ray, J Stickley, D Stoffler, B Stratmann, S Streitenberger, F Strutz, J Stubbs, J Stumpf, N Suazo, P Suchinda, R Suckling, A Sudin, K Sugamori, H Sugawara, K Sugawara, D Sugimoto, H Sugiyama, H Sugiyama, T Sugiyama, M Sullivan, M Sumi, N Suresh, D Sutton, H Suzuki, R Suzuki, Y Suzuki, Y Suzuki, Y Suzuki, E Swanson, P Swift, S Syed, H Szerlip, M Taal, M Taddeo, C Tailor, K Tajima, M Takagi, K Takahashi, K Takahashi, M Takahashi, T Takahashi, E Takahira, T Takai, M Takaoka, J Takeoka, A Takesada, M Takezawa, M Talbot, J Taliercio, T Talsania, Y Tamori, R Tamura, Y Tamura, CHH Tan, EZZ Tan, A Tanabe, K Tanabe, A Tanaka, A Tanaka, N Tanaka, S Tang, Z Tang, K Tanigaki, M Tarlac, A Tatsuzawa, JF Tay, LL Tay, J Taylor, K Taylor, K Taylor, A Te, L Tenbusch, KS Teng, A Terakawa, J Terry, ZD Tham, S Tholl, G Thomas, KM Thong, D Tietjen, A Timadjer, H Tindall, S Tipper, K Tobin, N Toda, A Tokuyama, M Tolibas, A Tomita, T Tomita, J Tomlinson, L Tonks, J Topf, S Topping, A Torp, A Torres, F Totaro, P Toth, Y Toyonaga, F Tripodi, K Trivedi, E Tropman, D Tschope, J Tse, K Tsuji, S Tsunekawa, R Tsunoda, B Tucky, S Tufail, A Tuffaha, E Turan, H Turner, J Turner, M Turner, KR Tuttle, YL Tye, A Tyler, J Tyler, H Uchi, H Uchida, T Uchida, T Uchida, T Udagawa, S Ueda, Y Ueda, K Ueki, S Ugni, E Ugwu, R Umeno, C Unekawa, K Uozumi, K Urquia, A Valleteau, C Valletta, R van Erp, C Vanhoy, V Varad, R Varma, A Varughese, P Vasquez, A Vasseur, R Veelken, C Velagapudi, K Verdel, S Vettoretti, G Vezzoli, V Vielhauer, R Viera, E Vilar, S Villaruel, L Vinall, J Vinathan, M Visnjic, E Voigt, M von-Eynatten, M Vourvou, J Wada, J Wada, T Wada, Y Wada, K Wakayama, Y Wakita, K Wallendszus, T Walters, WH Wan Mohamad, L Wang, W Wang, X Wang, X Wang, Y Wang, C Wanner, S Wanninayake, H Watada, K Watanabe, K Watanabe, M Watanabe, H Waterfall, D Watkins, S Watson, L Weaving, B Weber, Y Webley, A Webster, M Webster, M Weetman, W Wei, H Weihprecht, L Weiland, J Weinmann-Menke, T Weinreich, R Wendt, Y Weng, M Whalen, G Whalley, R Wheatley, A Wheeler, J Wheeler, P Whelton, K White, B Whitmore, S Whittaker, J Wiebel, J Wiley, L Wilkinson, M Willett, A Williams, E Williams, K Williams, T Williams, A Wilson, P Wilson, L Wincott, E Wines, B Winkelmann, M Winkler, B Winter-Goodwin, J Witczak, J Wittes, M Wittmann, G Wolf, L Wolf, R Wolfling, C Wong, E Wong, HS Wong, LW Wong, YH Wong, A Wonnacott, A Wood, L Wood, H Woodhouse, N Wooding, A Woodman, K Wren, J Wu, P Wu, S Xia, H Xiao, X Xiao, Y Xie, C Xu, Y Xu, H Xue, H Yahaya, H Yalamanchili, A Yamada, N Yamada, K 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The Lancet Diabetes & Endocrinology   12 ( 1 )   39 - 50   2024.1

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/s2213-8587(23)00321-2

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Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial Reviewed

PK Judge, N Staplin, KJ Mayne, C Wanner, JB Green, SJ Hauske, JR Emberson, D Preiss, SYA Ng, AJ Roddick, E Sammons, D Zhu, M Hill, W Stevens, K Wallendszus, S Brenner, AK Cheung, ZH Liu, J Li, LS Hooi, WJ Liu, T Kadowaki, M Nangaku, A Levin, D Cherney, AP Maggioni, R Pontremoli, R Deo, S Goto, X Rossello, KR Tuttle, D Steubl, D Massey, MJ Landray, C Baigent, R Haynes, WG Herrington, S Abat, R Abd Rahman, R Abdul Cader, MI Abdul Hafidz, MZ Abdul Wahab, NK Abdullah, T Abdul-Samad, M Abe, N Abraham, S Acheampong, P Achiri, JA Acosta, A Adeleke, V Adell, R Adewuyi-Dalton, N Adnan, A Africano, M Agharazii, F Aguilar, A Aguilera, M Ahmad, MK Ahmad, NA Ahmad, NH Ahmad, NI Ahmad, N Ahmad Miswan, H Ahmad Rosdi, I Ahmed, S Ahmed, S Ahmed, J Aiello, A Aitken, R AitSadi, S Aker, S Akimoto, A Akinfolarin, S Akram, F Alberici, C Albert, L Aldrich, M Alegata, L Alexander, S Alfaress, M Alhadj Ali, A Ali, A Ali, R Alicic, A Aliu, R Almaraz, R Almasarwah, J Almeida, A Aloisi, L Al-Rabadi, D Alscher, P 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Shimano, Y Shimizu, H Shimoda, K Shin, G Shivashankar, N Shojima, R Silva, CSB Sim, K Simmons, S Sinha, T Sitter, S Sivanandam, M Skipper, K Sloan, L Sloan, R Smith, J Smyth, T Sobande, M Sobata, S Somalanka, X Song, F Sonntag, B Sood, SY Sor, J Soufer, H Sparks, G Spatoliatore, T Spinola, S Squyres, A Srivastava, J Stanfield, N Staplin, K Staylor, A Steele, O Steen, D Steffl, J Stegbauer, C Stellbrink, E Stellbrink, W Stevens, A Stevenson, V Stewart-Ray, J Stickley, D Stoffler, B Stratmann, S Streitenberger, F Strutz, J Stubbs, J Stumpf, N Suazo, P Suchinda, R Suckling, A Sudin, K Sugamori, H Sugawara, K Sugawara, D Sugimoto, H Sugiyama, H Sugiyama, T Sugiyama, M Sullivan, M Sumi, N Suresh, D Sutton, H Suzuki, R Suzuki, Y Suzuki, Y Suzuki, Y Suzuki, E Swanson, P Swift, S Syed, H Szerlip, M Taal, M Taddeo, C Tailor, K Tajima, M Takagi, K Takahashi, K Takahashi, M Takahashi, T Takahashi, E Takahira, T Takai, M Takaoka, J Takeoka, A Takesada, M Takezawa, M Talbot, J Taliercio, T Talsania, Y Tamori, R Tamura, Y Tamura, CHH Tan, EZZ Tan, A Tanabe, K Tanabe, A Tanaka, A Tanaka, N Tanaka, S Tang, Z Tang, K Tanigaki, M Tarlac, A Tatsuzawa, JF Tay, LL Tay, J Taylor, K Taylor, K Taylor, A Te, L Tenbusch, KS Teng, A Terakawa, J Terry, ZD Tham, S Tholl, G Thomas, KM Thong, D Tietjen, A Timadjer, H Tindall, S Tipper, K Tobin, N Toda, A Tokuyama, M Tolibas, A Tomita, T Tomita, J Tomlinson, L Tonks, J Topf, S Topping, A Torp, A Torres, F Totaro, P Toth, Y Toyonaga, F Tripodi, K Trivedi, E Tropman, D Tschope, J Tse, K Tsuji, S Tsunekawa, R Tsunoda, B Tucky, S Tufail, A Tuffaha, E Turan, H Turner, J Turner, M Turner, KR Tuttle, YL Tye, A Tyler, J Tyler, H Uchi, H Uchida, T Uchida, T Uchida, T Udagawa, S Ueda, Y Ueda, K Ueki, S Ugni, E Ugwu, R Umeno, C Unekawa, K Uozumi, K Urquia, A Valleteau, C Valletta, R van Erp, C Vanhoy, V Varad, R Varma, A Varughese, P Vasquez, A Vasseur, R Veelken, C Velagapudi, K Verdel, S Vettoretti, G Vezzoli, V Vielhauer, R Viera, E Vilar, S Villaruel, L Vinall, J Vinathan, M Visnjic, E Voigt, M von-Eynatten, M Vourvou, J Wada, J Wada, T Wada, Y Wada, K Wakayama, Y Wakita, K Wallendszus, T Walters, WH Wan Mohamad, L Wang, W Wang, X Wang, X Wang, Y Wang, C Wanner, S Wanninayake, H Watada, K Watanabe, K Watanabe, M Watanabe, H Waterfall, D Watkins, S Watson, L Weaving, B Weber, Y Webley, A Webster, M Webster, M Weetman, W Wei, H Weihprecht, L Weiland, J Weinmann-Menke, T Weinreich, R Wendt, Y Weng, M Whalen, G Whalley, R Wheatley, A Wheeler, J Wheeler, P Whelton, K White, B Whitmore, S Whittaker, J Wiebel, J Wiley, L Wilkinson, M Willett, A Williams, E Williams, K Williams, T Williams, A Wilson, P Wilson, L Wincott, E Wines, B Winkelmann, M Winkler, B Winter-Goodwin, J Witczak, J Wittes, M Wittmann, G Wolf, L Wolf, R Wolfling, C Wong, E Wong, HS Wong, LW Wong, YH Wong, A Wonnacott, A Wood, L Wood, H Woodhouse, N Wooding, A Woodman, K Wren, J Wu, P Wu, S Xia, H Xiao, X Xiao, Y Xie, C Xu, Y Xu, H Xue, H Yahaya, H Yalamanchili, A Yamada, N Yamada, K Yamagata, M Yamaguchi, Y Yamaji, A Yamamoto, S Yamamoto, S Yamamoto, T Yamamoto, A Yamanaka, T Yamano, Y Yamanouchi, N Yamasaki, Y Yamasaki, Y Yamasaki, C Yamashita, T Yamauchi, Q Yan, E Yanagisawa, F Yang, L Yang, S Yano, S Yao, Y Yao, S Yarlagadda, Y Yasuda, V Yiu, T Yokoyama, S Yoshida, E Yoshidome, H Yoshikawa, A Young, T Young, V Yousif, H Yu, Y Yu, K Yuasa, N Yusof, N Zalunardo, B Zander, R Zani, F Zappulo, M Zayed, B Zemann, P Zettergren, H Zhang, L Zhang, L Zhang, N Zhang, X Zhang, J Zhao, L Zhao, S Zhao, Z Zhao, H Zhong, N Zhou, S Zhou, D Zhu, L Zhu, S Zhu, M Zietz, M Zippo, F Zirino, FH Zulkipli

The Lancet Diabetes & Endocrinology   12 ( 1 )   51 - 60   2024.1

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/s2213-8587(23)00322-4

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Review of a Series of Surveys on Adverse Reactions to the COVID-19 mRNA-1273 Vaccine at Okayama University. Reviewed

Naomi Matsumoto, Chigusa Higuchi, Chikara Miyaji, Toshiharu Mitsuhashi, Hideharu Hagiya, Soshi Takao, Takashi Yorifuji

Acta medica Okayama   77 ( 6 )   567 - 575   2023.12

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Language：English   Publishing type：Research paper (scientific journal)  

This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic.

DOI： 10.18926/AMO/66148

PubMed

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Initial Two Doses of COVID-19 Vaccine mRNA-1273 for an Individual Previously Vaccinated with Two Doses of an Inactivated Vaccine CoronaVac That Has Not Been Approved in Japan Reviewed

Yoshiaki Iwasaki, Chigusa Higuchi

77 ( 1 )   105 - 109   2023.2

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DOI： 10.18926/AMO/64370

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Empagliflozin in Patients with Chronic Kidney Disease Reviewed

New England Journal of Medicine   388 ( 2 )   117 - 127   2023.1

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Publishing type：Research paper (scientific journal)   Publisher：Massachusetts Medical Society  

DOI： 10.1056/nejmoa2204233

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Association between fever and antibody titer trends after a third dose of the mRNA-1273 vaccine. Reviewed

Naomi Matsumoto, Tomoka Kadowaki, Rumi Matsuo, Ayako Sasaki, Chikara Miyaji, Chigusa Higuchi, Masanori Nakayama, Yasue Sakurada, Hideharu Hagiya, Soshi Takao, Fumio Otsuka, Takashi Yorifuji

Journal of epidemiology   32 ( 12 )   567 - 569   2022.8

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2188/jea.JE20220210

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Adverse reactions and attitudes toward vaccines among young populations one month after receiving a second dose of mRNA-1273 in Japan. Reviewed

Naomi Matsumoto, Chigusa Higuchi, Toshiharu Mitsuhashi, Hideharu Hagiya, Soshi Takao, Takashi Yorifuji

Global health & medicine   4 ( 2 )   141 - 143   2022.4

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Language：English   Publishing type：Research paper (scientific journal)  

To investigate adverse reactions and attitudes toward the vaccine during the first month after mRNA- 1273 vaccination in a larger sample including younger men and women in Japan, we distributed a 1-month post-vaccination questionnaire using a Google form to 8,566 people who received a second dose of mRNA-1273 at Okayama University. The response rate was about 40.2% (3,447 responses), the sex ratio was about the same, and 73.3 % (2,528 respondents) were students in their twenties or younger. Poisson regression with robust variance was performed to calculate the prevalence ratio of each symptom by different attributes. The most common adverse reactions after the second vaccine dose were local pain (80.4%), fever (85.1%), malaise (82.0%), headache (64.0%), and chills (57.4%). Approximately 99% of respondents reported that their adverse reactions resolved within 1 week. Over 80% of respondents were satisfied with their vaccination (87.2%), expressed interest in receiving the third vaccination (83.3%), and would recommend vaccination to their loved ones (80.2%). However, among them, 22.0% (757 respondents) would recommend and 28.4% (980 respondents) also stated that they would consider the type of vaccine in these decisions.

DOI： 10.35772/ghm.2021.01125

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Questionnaire Survey on COVID-19 Vaccination at Okayama University in Japan: Factors Promoting Vaccination Among Young Adults Reviewed

Chigusa Higuchi, Naomi Matsumoto, Yoshiaki Iwasaki, Takashi Yorifuji, Junichiro Yamazaki, Yasutomo Nasu, Hirofumi Makino

Journal of Disaster Research   17 ( 1 )   21 - 30   2022.1

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Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Fuji Technology Press Ltd.  

COVID-19 has been prevalent worldwide since 2019. Increasing COVID-19 vaccination coverage is an important measure to combat the disease. An online survey was conducted with university students and personnel who were vaccinated against COVID-19 at a mass vaccination event to examine the factors promoting vaccination among young adults. The online survey was conducted with persons vaccinated at Okayama University from June 5 to September 27, 2021. Although the number of those who had fever >37.5°C increased after the second vaccination compared to the first, the vaccinated persons got more satisfied after the second shot.

DOI： 10.20965/jdr.2022.p0021

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Circulating GPIHBP1 levels and microvascular complications in patients with type 2 diabetes: A cross-sectional study. Reviewed International journal

Naoko Kurooka, Jun Eguchi, Kazutoshi Murakami, Shinji Kamei, Toru Kikutsuji, Sakiko Sasaki, Akiho Seki, Satoshi Yamaguchi, Ichiro Nojima, Mayu Watanabe, Chigusa Higuchi, Akihiro Katayama, Haruhito A Uchida, Atsuko Nakatsuka, Kenichi Shikata, Jun Wada

Journal of clinical lipidology   16 ( 2 )   237 - 245   2022.1

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) plays a crucial role in lipolytic processing. Previous studies have shown that GPIHBP1 mutations cause severe hypertriglyceridemia and that serum GPIHBP1 levels are marginally higher in patients with coronary heart disease; however, the role of GPIHBP1 in type 2 diabetes mellitus (T2DM) remains unknown. OBJECTIVE: We investigated the association between circulating GPIHBP1 levels and the prevalence of microvascular complications in T2DM. METHODS: A total of 237 subjects with T2DM and 235 non-diabetic control subjects were enrolled in this study. Their serum GPIHBP1 levels were evaluated using ELISA assays. RESULTS: Circulating GPIHBP1 levels were higher in patients with T2DM (952.7 pg/mL [761.3-1234.6], p < 0.0001) than in non-diabetic subjects (700.6 [570.8-829.6]), but did not differ in T2DM patients with or without hypertriglyceridemia. Serum GPIHBP1 levels were significantly higher in patients with T2DM with diabetic retinopathy (DR), diabetic nephropathy (DN), and microvascular complications than in those without these complications. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses revealed that the presence of microvascular complications, but not macrovascular complications, was independently associated with serum GPIHBP1 levels, which could predict the presence of diabetic microvascular complications. CONCLUSIONS: Elevated GPIHBP1 levels are associated with microvascular complications in T2DM and may help to predict their progression.

DOI： 10.1016/j.jacl.2022.01.006

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インスリン抵抗性/肥満 肥満・2型糖尿病におけるmir221/222の機能解析 Reviewed

山口 哲志, 片山 晶博, 樋口 千草, 中司 敦子, 江口 潤, 和田 淳

糖尿病合併症   35 ( Suppl. )   237 - 237   2021.9

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Language：Japanese   Publisher：(一社)日本糖尿病合併症学会  

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インスリン抵抗性/肥満 食負荷肥満マウスと視床下部食欲制御マウスにおけるMir342発現上昇(Upregulation of Mir342 in diet-induced obesity mouse and the hypothalamic appetite control) Reviewed

張 冬曉, 山口 哲志, 樋口 千草, 中司 敦子, 江口 潤, 和田 淳

糖尿病合併症   35 ( Suppl. )   239 - 239   2021.9

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Language：English   Publisher：(一社)日本糖尿病合併症学会  

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Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients With Type 2 Diabetes: A Multicenter Prospective Study With 5-Year Follow Up (U-CARE Study 2) Reviewed International journal

Koki Mise, Mariko Imamura, Satoshi Yamaguchi, Mayu Watanabe, Chigusa Higuchi, Akihiro Katayama, Satoshi Miyamoto, Haruhito A. Uchida, Atsuko Nakatsuka, Jun Eguchi, Kazuyuki Hida, Tatsuaki Nakato, Atsuhito Tone, Sanae Teshigawara, Takashi Matsuoka, Shinji Kamei, Kazutoshi Murakami, Ikki Shimizu, Katsuhiro Miyashita, Shinichiro Ando, Tomokazu Nunoue, Michihiro Yoshida, Masao Yamada, Kenichi Shikata, Jun Wada

Frontiers in Cardiovascular Medicine   8   668059 - 668059   2021.5

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

<bold>Background:</bold> Although various biomarkers predict cardiovascular event (CVE) in patients with diabetes, the relationship of urinary glycan profile with CVE in patients with diabetes remains unclear.

<bold>Methods:</bold> Among 680 patients with type 2 diabetes, we examined the baseline urinary glycan signals binding to 45 lectins with different specificities. Primary outcome was defined as CVE including cardiovascular disease, stroke, and peripheral arterial disease.

<bold>Results:</bold> During approximately a 5-year follow-up period, 62 patients reached the endpoint. Cox proportional hazards analysis revealed that urinary glycan signals binding to two lectins were significantly associated with the outcome after adjustment for known indicators of CVE and for false discovery rate, as well as increased model fitness. Hazard ratios for these lectins (+1 SD for the glycan index) were UDA (recognizing glycan: mixture of Man5 to Man9): 1.78 (95% CI: 1.24–2.55, <italic>P</italic> = 0.002) and Calsepa [High-Man (Man2–6)]: 1.56 (1.19–2.04, <italic>P</italic> = 0.001). Common glycan binding to these lectins was high-mannose type of <italic>N</italic>-glycans. Moreover, adding glycan index for UDA to a model including known confounders improved the outcome prediction [Difference of Harrel's C-index: 0.028 (95% CI: 0.001–0.055, <italic>P</italic> = 0.044), net reclassification improvement at 5-year risk increased by 0.368 (0.045–0.692, <italic>P</italic> = 0.026), and the Akaike information criterion and Bayesian information criterion decreased from 725.7 to 716.5, and 761.8 to 757.2, respectively].

<bold>Conclusion:</bold> The urinary excretion of high-mannose glycan may be a valuable biomarker for improving prediction of CVE in patients with type 2 diabetes, and provides the rationale to explore the mechanism underlying abnormal <italic>N</italic>-glycosylation occurring in patients with diabetes at higher risk of CVE.

<bold>Trial Registration:</bold> This study was registered with the University Hospital Medical Information Network on June 26, 2012 (Clinical trial number: UMIN000011525, URL: <ext-link>https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013482</ext-link>).

DOI： 10.3389/fcvm.2021.668059

PubMed

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当院におけるTime-In-Range(TIR)とHbA1cとの関連についての検討 Reviewed

片山 晶博, 野島 一郎, 樋口 千草, 渡邉 真由, 宮本 聡, 中司 敦子, 江口 潤, 四方 賢一, 和田 淳

糖尿病   63 ( Suppl.1 )   S - 220   2020.8

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Language：Japanese   Publisher：(一社)日本糖尿病学会  

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学生の非アルコール性脂肪性肝疾患における遺伝的素因の検討

岩崎 良章, 中山 光, 森田 知子, 岡 香織, 樋口 千草, 二宮 崇, 黒木 清美, 中西 順子, 山際 陽子, 影山 真希, 古本 友理, 内藤 惠子, 河原 宏子, 岡部 伸幸, 大西 勝

CAMPUS HEALTH   57 ( 1 )   63 - 63   2020.3

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Language：Japanese   Publisher：(公社)全国大学保健管理協会  

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社会保険労務士との協働によるメンタルヘルス支援

兒山 志保美, 大西 勝, 河原 宏子, 岡部 伸幸, 中西 順子, 岡 香織, 黒木 清美, 樋口 千草, 二宮 崇, 岩崎 良章

CAMPUS HEALTH   57 ( 1 )   271 - 272   2020.3

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Language：Japanese   Publisher：(公社)全国大学保健管理協会  

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留学生定期健康診断における胸部X線検査所見の検討

二宮 崇, 山際 陽子, 岡 香織, 黒木 清美, 古本 友理, 内藤 惠子, 影山 真希, 樋口 千草, 河原 宏子, 岡部 伸幸, 大西 勝, 岩崎 良章

CAMPUS HEALTH   57 ( 1 )   335 - 337   2020.3

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Language：Japanese   Publisher：(公社)全国大学保健管理協会  

本学では留学生を積極的に受け入れる方針としており、最近5年間で増加している。今回、2014〜2018年度に入学し定期健診で胸部X線検査を受けた留学生のべ3107名のX線所見を調査し、経年的変化について検討した。各年度の有所見者割合は7.0〜18.5%でバラツキがあり、2016年度が最も高かった。要精査率は2.2〜4.0%で年度間の大差は認めなかった。結核高負担国からの留学生と高負担国以外からの留学生とで有所見率を比較すると、高負担国以外のほうがやや高く、要精査率についても同様であった。有所見や要精査と判定された部位を高負担国と高負担国以外で比較すると、高負担国では肺や心臓の占める割合が高く、高負担国以外では肺や心臓の占める割合は高負担国ほどではなく、椎骨の占める割合が高かった。

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インスリンポンプ療法からSAP療法への治療変更効果に関する後ろ向き観察研究 Reviewed

山口 哲志, 利根 淳仁, 勅使川原 早苗, 渡邊 真由, 片山 晶博, 宮本 聡, 江口 潤, 中司 敦子, 樋口 千草, 小川 大輔, 四方 賢一, 和田 淳

糖尿病   62 ( 5 )   315 - 321   2019.5

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Language：Japanese   Publisher：(一社)日本糖尿病学会  

本研究はSAP導入後の効果を検討するため、CSIIからSAPに変更後1年以上経過した1型糖尿病22症例を解析した後ろ向き観察研究である。HbA1cはSAP前と比較して6ヵ月(6M)では不変、12Mで有意に低下した(各々7.6±0.7%、7.4±0.9%、7.1±0.9%)。6Mの時点でHbA1c0.1%以上低下した群を6M低下群、変化なし又は0.1%以上上昇した群を6M不変・上昇群と定義したところ、6M不変・上昇群で0MのHbA1cが有意に低値で、重回帰分析では基礎インスリン比率の変化(6M)がHbA1c変化量(6M)の有意な決定因子として採用され、負の相関を示した。また、6M不変・上昇群では0MのSMBGで低血糖頻度が有意に高く、1Mで有意に低下した。臨床的にSMBGでの低血糖が多い症例ではSAP導入後にHbA1c上昇を呈す事もあり、注意を要する。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00926&link_issn=&doc_id=20190603330001&doc_link_id=10.11213%2Ftonyobyo.62.315&url=https%3A%2F%2Fdoi.org%2F10.11213%2Ftonyobyo.62.315&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif