Papers - OKADA Shunsuke

Incidental finding of papillary thyroid carcinoma on CT examination of mandibular lesion: Case report. Reviewed International journal

Irfan Sugianto, Yoshinobu Yanagi, Hidenobu Konouchi, Miki Hisatomi, Shunsuke Okada, Babatunde O Bamgbose, Junichi Asaumi

Molecular and clinical oncology   8 ( 1 )   183 - 187   2018.1

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPANDIDOS PUBL LTD  

The number of significant incidental findings identified on radiographic examinations has increased. In total, 169 patients, 87 males and 82 females, with a mean age of 67.3 years (range, 17-92 years), as well as 65 patients (38.5%), 43 (66.2%) female and 22 (33.8%) male had abnormal findings in the thyroid for one year in our institution. Thyroid nodules are the most common incidental findings on oral and maxillofacial evaluations. Computed tomography (CT) and magnetic resonance imaging (MRI) examination are frequently used to detect thyroid abnormality. The present study reported a case of papillary thyroid carcinoma (PTC) detected following CT and MRI examination of a mandibular lesion. The CT examination of the oral and maxillofacial region included the thyroid, which must be examined carefully to detect various diseases, including PTC. Collaboration between radiologists and clinicians is important to manage these incidental findings.

DOI： 10.3892/mco.2017.1478

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PubMed

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Diagnostic Value of Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging for Multilocular Ameloblastoma Reviewed

Irfan Sugianto, Hironobu Konouchi, Yohei Takeshita, Shunsuke Okada, Risa Matsubara, Miki Hisatomi, Jun Murakami, Babatunde O. Bamgbose, Yoshinobu Yanagi, Junichi Asaumi

JOURNAL OF HARD TISSUE BIOLOGY   27 ( 4 )   275 - 280   2018

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：JOURNAL HARD TISSUE BIOLOGY  

Contrast-enhanced (CE)-MR image is useful to distinguish cystic and solid portions on multilocular lesion, however, the CE-MR examination is contraindicated in patients with kidney disease. Fluid-attenuated inversion recovery (FLAIR) image is one of methods which signal of fluid is suppressed. This study investigated qualitatively and quantitatively whether FLAIR images were useful for detecting and differentiating cystic and solid portions of multilocular ameloblastomas. We retrospectively reviewed 11 cases of multilocular ameloblastoma. FLAIR and short Ti inversion recovery (STIR) sequences were performed in all cases. CE-MR images in 10 cases, and T1-weighted images (T1WI) in 7 cases. FLAIR, STIR, CE-MR, and T1WI images were visually evaluated (qualitative analysis). Signal-to-noise ratio (SNR) of cystic and solid portions were measured and compared among the images of all sequences (quantitative analysis). FLAIR imaging could detect cystic portions with very low SI in all cases because cystic fluid was well suppressed on the images, and the solid portion showed intermediate SI. On some STIR images, the solid portion was masked by the markedly high SI of the cystic fluid. CE-T1WI and CE-FLAIR images showed no enhancement of the cystic portion but enhancement of the solid portion. On FLAIR image, SNR of solid was higher than cystic portion (p < 0.05). Cystic and solid portions of a lesion could be detected and distinguished on FLAIR imaging. FLAIR images are thus useful for diagnosing multilocular ameloblastoma when CE-MR cannot be performed.

DOI： 10.2485/jhtb.27.275

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頭頸部癌マウスモデルを用いた分子イメージングによる抗癌剤セツキシマブ感受性の評価

岡田 俊輔

岡山歯学会雑誌   36 ( 1 )   1 - 8   2017.6

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Authorship：Lead author   Language：Japanese   Publisher：岡山歯学会  

腫瘍の増殖能や転移能に関与する生体内分子を標的とした陽電子断層撮影法(PET)のプローブを作製し、腫瘍の機能的な病態を画像上で予測することを目的とした。実験動物には7週齢BALB/cAJcl-nu/nuヌードマウスを用いた。PETプローブの作製、PET撮像および画像解析、ガンマカウンターを用いた%ID/g tissue値の計測、上皮成長因子受容体(EGFR)発現の免疫組織学的検討を行った。その結果、頭頸部癌に用いられる抗癌剤であるセツキシマブを89Zrで標識したものをPETプローブとして用いることで、EGFRの発現を可視化し、頭頸部癌のセツキシマブ感受性の評価を画像上で非侵襲的に行うことが可能となった。放射性核種の選択によっては、診断のみならず治療に応用できる可能性が考えられた。臨床応用を考える際には、放射性核種の半減期やプローブの代謝経路を考慮し、腫瘍部位以外での被曝についても検討していく必要があると考えられた。

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Diagnostic value of MR imaging for dentigerous cysts Reviewed

Hironobu Konouchi, Jun-ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Emiko Saito Arita, Plauto Christopher Aranha Watanabe, Jun Murakami, Teruhisa Unetsubo, Mariko Fujita, Shunsuke Okada, Hidenobu Matsuzaki, Toshihiko Takenobu, Toru Wakasa

ORAL RADIOLOGY   30 ( 1 )   13 - 19   2014.1

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

It is known that the magnetic resonance (MR) imaging features of dentigerous cysts (DCs) are the same as those of other cysts. The cavities of DCs generally show low signal intensity (SI) on T1-weighted imaging (T1WI). However, in our experience, DCs often show high SI on T1WI, rendering them difficult to distinguish from keratocystic odontogenic tumors (KCOTs). In this study, we evaluated seven cases of DC and 23 cases of KCOT to assess whether MR imaging can provide additional information for the differential diagnosis of DC and KCOT.Two trials were evaluated. The first trial was an analysis of the cystic cavity SI on T1WI. To compare the SI between patients, we performed T1WI with contrast (T1c). The second trial analyzed the SI uniformity (U (I )) pound on T1WI, T2-weighted imaging (T2WI), and short inversion time inversion recovery (STIR) images of the cystic cavity, because it has been reported that an MR imaging feature of KCOT is heterogeneous SI. Statistical analyses were performed using the Mann-Whitney U test and a receiver operating characteristic (ROC) curve.The T1c values of DCs were significantly higher than those for KCOTs. The U (I ) pound values on T1WI and STIR images were significantly higher for DCs than for KCOTs. The T1c cutoff values (0.66 and 0.84) and U (I ) pound cutoff values for T1WI (82.1 %) and STIR images (79.8 %) were determined from the ROC analyses.T1c and U (I ) pound values provide useful additional information for the differential diagnosis of DC and KCOT.

DOI： 10.1007/s11282-013-0128-2

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