Papers - OKADA Shunsuke

Helpfulness of effective atomic number image in forensic dental identification: Photon-counting computed tomography is suitable Reviewed

Takashi Asahara, Shunsuke Okada, Hiroaki Hayashi, Tatsuya Maeda, Rina Nishigami, Daiki Kobayashi, Chihiro Kurose, Natsumi Kimoto, Sota Goto, Miki Hisatomi, Yoshinobu Yanagi, Toshihiro Iguchi

Computers in Biology and Medicine   184   109333 - 109333   2025.1

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.compbiomed.2024.109333

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Evaluation of CT Findings in Squamous and Non-Squamous Cell Carcinomas of the Maxillary Sinus

Yuka Asaumi, Mamiko Fujikura, Miki Hisatomi, Wlla E. Al-Hammad, Yohei Takeshita, Shunsuke Okada, Toshiyuki Kawazu, Yoshinobu Yanagi, Junichi Asaumi

Journal of Hard Tissue Biology   34 ( 1 )   35 - 40   2025

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Publishing type：Research paper (scientific journal)   Publisher：Society for Hard Tissue Regenerative Biology  

DOI： 10.2485/jhtb.34.35

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Central dentinogenic ghost cell tumor of the maxilla: a case report with new imaging findings and review of the literature Reviewed

Suzuka Yoshida, Yohei Takeshita, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Kyoichi Obata, Kiyofumi Takabatake, Saori Yoshida, Junichi Asaumi

Oral Radiology   2024.7

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

A dentinogenic ghost cell tumor (DGCT) is a rare benign odontogenic tumor that commonly shows characteristics of solid proliferation and has a relatively high risk of recurrence after surgical treatment. We herein report a case of a central DGCT that occurred in the maxilla and resulted in bone expansion. This study highlights new imaging findings (particularly magnetic resonance imaging) along with histopathological observations. In addition, we conducted a review of the existing literature on this rare tumor. A 37-year-old man developed swelling around the right cheek. A benign odontogenic tumor such as ameloblastoma was suspected based on the imaging examination findings (including bone expansion and the internal characteristics of the tumor) on panoramic imaging, computed tomography, and magnetic resonance imaging. The lesion was surgically excised from the right maxilla. Postoperative histopathological examination led to a definitive diagnosis of central DGCT. The tumor comprised epithelial neoplastic islands, resembling ameloblastoma, inside tight fibroconnective tissue; masses of ghost cells and formation of dentin were also observed. We had suspected that the minute high-density region around the molars on the imaging examinations represented alveolar bone change; however, it represented dentin formation. This led to difficulty diagnosing the lesion. Although DGCT may present characteristic findings on imaging examinations, its occurrence is infrequent, and in some cases, the findings may include the presence or absence of an impacted tooth without obvious calcification. The present case suggests that we should consider the possibility of an odontogenic tumor with calcification when high-density structures are observed inside the lesion.

DOI： 10.1007/s11282-024-00764-4

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Other Link： https://link.springer.com/article/10.1007/s11282-024-00764-4/fulltext.html

Magnetic Resonance Imaging Signal Intensity in the Characterization of Odontogenic Lesions: A Systematic Review Reviewed International coauthorship International journal

Munhoz Luciana, Okada Shunsuke, Hisatomi Miki, Fujita Mariko, Shimizu Yudai, Yanagi Yoshinobu, Arita Emiko Saito, Asaumi Jun-Ich

International Journal of Radiology and Imaging Technology   10 ( 1 )   2024.6

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Publishing type：Research paper (scientific journal)   Publisher：ClinMed International Library  

DOI： 10.23937/2572-3235.1510118

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Are computed tomography images of the mandible useful in age and sex determination? A forensic science meta-analysis Reviewed

L. Munhoz, S. Okada, M. Hisatomi, Y. Yanagi, E. S. Arita, J. Asaumi

The Journal of forensic odonto-stomatology   42 ( 1 )   38 - 57   2024.4

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Publishing type：Research paper (scientific journal)  

OBJECTIVES: This meta-analysis addresses the use of mandibular computed tomography (CT) scans for age and/or sex determination in forensic science. METHODS: Six databases were searched until June 2023, using the keyword "mandible" combined with keywords related to "multislice computed tomography" (MCT) or "cone-beam computed tomography" (CBCT) and keywords related to "skeletal age determination" or "sex determination analysis." MAIN RESULTS: Among the 23 studies included, 11 used MCT and 12 used CBCT to perform forensic assessments. Age determination was the aim of a single study, sex and agedeterminations were the objective of five studies, and the other studies investigated the determination of sex only. Metaanalysis could be performed only for sex determination. CONCLUSIONS: Mandible measurements are useful in sex determination, as the bicondylar and bigonial breadth are larger in males than in females. For the mandible angle, the meta-analysis results confirm sex dimorphism in CBCT scans but not in MCT scans. For age estimation, further studies are needed to prove that the mandible hole is a reliable parameter for age estimation. PROSPERO registration number: CRD42021260967.

DOI： 10.5281/zenodo.11058169

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Imaging characteristics of incidentally detected cosmetic surgery-derived foreign bodies on CT images in the maxillofacial region Reviewed

Miki Hisatomi, Yohei Takeshita, Yoshinobu Yanagi, Shunsuke Okada, Mamiko Fujikura, Suzuka Yoshida, Toshiyuki Kawazu, Junichi Asaumi

Oral Radiology   2024.4

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Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s11282-023-00734-2

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Preliminary Study of Dental Caries Detection by Deep Neural Network Applying Domain-Specific Transfer Learning Reviewed

Toshiyuki Kawazu, Yohei Takeshita, Mamiko Fujikura, Shunsuke Okada, Miki Hisatomi, Junichi Asaumi

Journal of Medical and Biological Engineering   44 ( 1 )   43 - 48   2024.2

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Purpose: The purpose of this study is to confirm whether it is possible to acquire a certain degree of diagnostic ability even with a small dataset using domain-specific transfer learning. In this study, we constructed a simulated caries detection model on panoramic tomography using transfer learning. Methods: A simulated caries model was trained and validated using 1094 trimmed intraoral images. A convolutional neural network (CNN) with three convolution and three max pooling layers was developed. We applied this caries detection model to 50 panoramic images and evaluated its diagnostic performance. Results: The diagnostic performance of the CNN model on the intraoral film was as follows: C0 84.6%; C1 90.6%; C2 88.6%. Finally, we tested 50 panoramic images with simulated caries insertion. The diagnostic performance of the CNN model on the panoramic image was as follows: C0 75.0%, C1 80.0%, C2 80.0%, and overall diagnostic accuracy was 78.0%. The diagnostic performance of the caries detection model constructed only with panoramic images was much lower than that of the intraoral film. Conclusion: Domain-specific transfer learning methods may be useful for saving datasets and training time (179/250).

DOI： 10.1007/s40846-024-00848-w

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Radiological assessment of the dissection area in supraomohyoid neck dissection Reviewed

Yohei Takeshita, Joe Iwanaga, Yoshio Ohyama, Soichiro Ibaragi, Yuki Matsushita, R. Shane Tubbs, Norio Kitagawa, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Junichi Asaumi

Surgical and Radiologic Anatomy   2024

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Purpose: The current supraomohyoid neck dissection (SOHND) is performed above the omohyoid muscle to dissect levels I, II, and III in the levels of cervical lymph nodes. However, the anatomical boundary between levels III and IV is the inferior border of the cricoid cartilage. We investigated the anatomical relationship between the omohyoid muscle and cricoid cartilage using contrast-enhanced CT (CE-CT) images to assess the validity of the current SOHND. Methods: CE-CT images of the head and neck regions in patients were reviewed. The patients were divided into two groups: “malignant tumors” and “others”. The vertebral levels corresponding to the positions of anatomical structures such as the intersection of the omohyoid muscle and internal jugular vein (OM-IJ), and the inferior border of the cricoid cartilage (CC), were recorded. Results: The OM-IJ was located around the seventh cervical to the first thoracic vertebra. There was a significant difference between the malignant tumor and others groups in females (p = 0.036). The CC was located around the sixth to seventh cervical vertebrae. There was a significant sex difference in each group (malignant tumor: p < 0.0001; others: p = 0.008). Both sexes tended to have lower OM-IJ than CC, and females had significantly lower OM-IJ than males. Conclusion: This study provides clear anatomical evidence showing the difference between the SOHND dissection area and levels I, II, and III. It could be considered that in most cases SOHND invades level IV, not just levels I, II, and III, especially in female patients.

DOI： 10.1007/s00276-024-03453-3

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An imaging‑based diagnostic approach to vascular anomalies of the oral and maxillofacial region Reviewed International journal

Wlla Al‑Hammad, Mamiko Fujikura, Miki Hisatomi, Shunsuke Okada, Luciana Munhoz, Toshiyuki Kawazu, Yohei Takeshita, Mariko Fujita, Yoshinobu Yanagi, Jun-Ichi Asaumi

Oncology Letters   26 ( 3 )   394 - 394   2023.7

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Spandidos Publications  

The accurate diagnosis of vascular anomalies (VAs) is considered a challenging endeavor. Misdiagnosis of VAs can lead clinicians in the wrong direction, such as the performance of an unnecessary biopsy or inappropriate surgical procedures, which can potentially lead to unforeseen consequences and increase the risk of patient injury. The purpose of the present study was to develop an approach for the diagnosis of VAs of the oral and maxillofacial region based on computed tomography (CT), magnetic resonance imaging (MRI) and dynamic contrast-enhanced MRI (DCE-MRI). In the present study, the CT and MR images of 87 VAs were examined, and the following imaging features were evaluated: Detectability of the lesion, the periphery of the lesion, the inner nature of the lesion, the density of the lesion on CT, the signal intensity of the lesion on MRI, the detectability of phleboliths and the shape of the lesion. A total of 29 lesions were further evaluated using the contrast index (CI) curves created from the DCE-MRI images. A diagnostic diagram, which is based on the imaging features of VAs and CI curve patterns, was subsequently extrapolated. The results obtained demonstrated that the VAs were detected more readily by MRI compared with CT, whereas the detectability of phleboliths was superior when using CT compared with MRI. VAs showed a propensity for homogeneous isodensity on CT, whereas, by contrast, they exhibited a propensity for heterogeneous hyperdensity on CE-CT. VAs also showed a propensity for homogeneous intermediate signal intensity when performing T1-weighted imaging (T1WI), heterogeneous high signal intensity when performing short tau inversion recovery MRI, and heterogeneous high signal intensity when performing fat-saturated CE-T1WI. The CI curves of VAs were found to exhibit a specific pattern: Of the 29 CI curves, 23 (79.3%) showed early weak enhancement, followed by a plateau leading up to 400-600 sec. An imaging-based diagnostic diagram was ultimately formulated. This diagram can act as an aid for radiologists when they are expecting to find a VA, and hopefully serve the purpose of simplifying the diagnostic process. Taken together, the findings of the present study indicated that DCE-MRI may be considered a useful tool for the diagnosis of VAs.

DOI： 10.3892/ol.2023.13980

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Difficult Diagnosis of Osteosarcoma of the mandible: A Case Report Comparing Pathology and Imaging Findings Reviewed

Fujikura M, Kawazu T, Kawai H, Okada S, Yanagi Y, Asaumi J

2023

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Collision tumor of small cell carcinoma and squamous cell carcinoma of the maxillary sinus: Case report. Reviewed International journal

Irfan Sugianto, Yoshinobu Yanagi, Miki Hisatomi, Shunsuke Okada, Yohei Takeshita, Babatunde Olamide Bamgbose, Junichi Asaumi

Molecular and clinical oncology   16 ( 5 )   96 - 96   2022.5

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Language：English  

A collision tumor refers to the coexistence of two diagnostically distinct tumors in a common anatomic space. Collision tumors are rare in the oral and maxillofacial region. The present study reported on the case of an 82-year-old female with a collision tumor in the maxillary sinus consisting of small cell carcinoma (SmCC) and squamous cell carcinoma (SCC). Computed tomography (CT) imaging revealed a mass in the right maxillary sinus. The lesion exhibited heterogeneous low signal intensity (SI) on T1-weighted imaging (T1WI), high SI on short T1 inversion recovery and heterogeneous solid enhancement on contrast-enhanced T1WI. The histopathology result of a biopsy specimen confirmed SmCC. After the patient received a course of chemoradiotherapy, follow-up CT revealed a residual tumor. In a second surgery, a remaining tumor and histopathology revealed SCC with no evidence of SmCC. The final diagnosis was a collision tumor made up of SCC and SmCC.

DOI： 10.3892/mco.2022.2529

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Ultrasound procedure for the diagnosis of mass lesions in the oral region. Reviewed

Yohei Takeshita, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Saori Yoshida, Yuri Namba, Yudai Shimizu, Yoshinobu Yanagi, Junichi Asaumi

Oral radiology   39 ( 1 )   93 - 100   2022.3

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: To examine the diagnostic usefulness and procedures of ultrasonography (US) for mass lesions in the soft tissue of the oral region. METHODS: This study involved patients with mass lesions (tumorous lesions and cysts) who had undergone US and histopathological examinations from January 2017 to December 2019. The following points were evaluated by two observers using an evaluation scale: vascularity, echo intensity level, boundary, margin shape, distribution of internal echoes, and capsule. The usefulness of each point for differential diagnosis of tumorous lesions and cysts was statistically analyzed. RESULTS: Forty-five mass lesions in the soft tissue of the oral region (33 tumorous lesions and 12 cysts) were analyzed. There were significant differences in four evaluation points between the tumorous lesions and cysts: vascularity, echo intensity level, boundary, and margin shape. Cysts were almost completely excluded diagnostically, especially when vascularity was observed. There were also significant differences in two evaluation points between nonvascular tumorous lesions and cysts: echo intensity level and boundary. CONCLUSIONS: In US examination for mass lesions in the oral region, it was possible to diagnose tumorous lesions and exclude cysts when vascularity was observed. When vascularity was not observed, however, tumorous lesions and cysts could be identified using two evaluation points: echo intensity level and boundary.

DOI： 10.1007/s11282-022-00605-2

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Influence of mesiodens on adjacent teeth and the timing of its safe removal. Reviewed International journal

Majd Barham, Shunsuke Okada, Miki Hisatomi, Abdullah Khasawneh, Nouha Tekiki, Yohei Takeshita, Toshiyuki Kawazu, Mariko Fujita, Yoshinobu Yanagi, Junichi Asaumi

Imaging science in dentistry   52 ( 1 )   67 - 74   2022.3

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Language：English   Publishing type：Research paper (scientific journal)  

Purpose: To focus on the effects of the presence of mesiodens on adjacent teeth and to investigate the timing of its safe removal. Materials and Methods: Cone-beam computed tomography examinations, obtained at Okayama University Hospital over a three-year period, were inspected. Data were recorded including the number of mesiodens; associated abnormalities; and the relationship with neighboring structures. Depending on multiple factors, the risk of developing complications due to early extraction of a mesiodens was divided into three categories: high, medium, and low risk. Results: A total of 5,958 cone-beam computed tomography exams were obtained, 460 patients aged 3-85 years were diagnosed with a total of 568 mesiodens, 382 (67.3%) of which were discovered in young patients (age <10 years), and 333 (87.2%) of these were associated with abnormalities. Regarding the risk categories, 11 (1.9%) were considered to be in the high-risk, five (0.9%) in the medium-risk and 552 (97.2%) in the low-risk categories. Moreover, eight out of 11 high-risk mesiodens were extracted and no post-operative complications have been seen. Conclusion: As the results showed that no postoperative complications were seen in all the extracted cases of high-risk mesiodens, this indicates the possibility of safe extraction at an early age which could reduce related future complications.

DOI： 10.5624/isd.20210218

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Dynamic contrast-enhanced MRI as a predictor of programmed death ligand-1 expression in patients with oral squamous cell carcinoma. Reviewed International journal

Nouha Tekiki, Mariko Fujita, Tatsuo Okui, Hotaka Kawai, May Wathone Oo, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Yohei Takeshita, Majd Barham, Hitoshi Nagatsuka, Yoshinobu Yanagi, Jun-Ichi Asaumi

Oncology letters   22 ( 5 )   778 - 778   2021.11

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPANDIDOS PUBL LTD  

Immune checkpoint inhibitors (ICIs) targeting programmed death ligand-1 (PD-L1) are highly promising therapies for oral squamous cell carcinoma (OSCC). The assessment of PD-L1 expression may help predicting the therapeutic effect of ICIs and, thus, benefit patient selection. Contrast index (CI) parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) have been proven as efficient to assess microvessel density (MVD) in OSCC. The present study aimed to determine the correlation between DCE-MRI parameters and MVD and between DCE-MRI parameters and PD-L1 expression to determine whether DCE-MRI could be used non-invasively to evaluate PD-L1 expression in patients with OSCC. A total of 21 patients with primary OSCC who had undergone a 3T MRI scan, including DCE-MRI, were included in the present study, and CI curve-derived parameters were examined. The MVD and PD-L1 expression in the surgically resected specimens were analyzed using immunohistochemistry (IHC) staining for CD31 and IHC staining for PD-L1, respectively. The results demonstrated that the expression levels of these markers were correlated with DCE-MRI parameters. PD-L1 expression levels were found to be significantly correlated with the maximum CI (CI-max; P=0.007), peak CI (CI-peak; P=0.007), maximum CI gain (CI-gain; P=0.006) and MVD (P=0.001) values. The mean CI-max, CI-peak, CI-gain and MVD values were significantly higher in tumors with high PD-L1 expression (P<0.05). MVD levels were also significantly correlated with the time of CI-max (T-max; P=0.003) and CI-gain (P=0.037). The mean CI-gain was significantly increased, and the mean T-max was significantly shorter in high MVD tumors (P<0.05 and P<0.01, respectively). In summary, the findings from the present study confirmed the correlation between CI parameters, derived from DCE-MRI, and MVD, and suggested that these parameters may be correlated with PD-L1 expression in OSCC tumor cells.

DOI： 10.3892/ol.2021.13039

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Assessment of Hounsfield unit in the differential diagnosis of odontogenic cysts. Reviewed International journal

Kyonori Uehara, Miki Hisatomi, Luciana Munhoz, Toshiyuki Kawazu, Yoshinobu Yanagi, Shunsuke Okada, Yohei Takeshita, Emiko Arita Saito, Junichi Asaumi

Dento maxillo facial radiology   50 ( 2 )   20200188 - 20200188   2020.8

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: The purpose of this study was to evaluate the usefulness of Hounsfield unit (HU) assessment with multislice-CT in the differentiation of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs). METHODS: In total, 307 odontogenic cysts (RCs, DCs and OKCs) were included in this study. Cysts with lesion diameter <10 mm, cysts with artefacts affecting measurement of HU values, cysts involving infection and recurrent cysts were regarded as exclusion criteria. Images were acquired in three different types of CT scanners: Aquilion ONE, Discovery CT750 HD and SOMATOM Definition Flash. Differences in HU values among scanners and among types of odontogenic cysts were assessed using one-way analysis of variance; multiple comparisons were performed post hoc, using the Tukey-Kramer honestly significant difference test. RESULTS: In total, 164 cysts were analysed in this study (64 RCs, 57 DCs and 43 OKCs). Regardless of the type of lesion, the Aquilion ONE scanner demonstrated a significant difference in HU value, compared with the Discovery CT750 HD scanner. Regardless of CT scanner model, HU values significantly differed between DCs and OKCs (p < 0.0001), as well as between OKCs and RCs (p < 0.0001). CONCLUSIONS: HU values were found to vary among CT scanners and should always be associated with other lesion imaging features while interpreting and elaboration diagnostic hypothesis. Notably, the results suggested that OKCs might be able to be differentiated from DCs and RCs by using HU values.

DOI： 10.1259/dmfr.20200188

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Incidental findings in the thyroid gland on computed tomography images of the oral and maxillofacial region. Reviewed International journal

Abdullah Khasawneh, Yohei Takeshita, Miki Hisatomi, Toshiyuki Kawazu, Mariko Fujita, Shunsuke Okada, Yuri Namba, Yudai Shimizu, Yoshinobu Yanagi, Junichi Asaumi

Oncology letters   19 ( 3 )   2005 - 2010   2020.3

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPANDIDOS PUBL LTD  

The numbers of abnormal findings incidentally detected in adjacent regions are increasing with advances in imaging modalities. The present study aimed to examine the prevalence and characteristics of incidental findings in the thyroid gland on computed tomography (CT) images of the oral and maxillofacial region. CT scans of the oral and maxillofacial region in patients obtained between January 2012 and December 2016 were retrospectively reviewed. Images that revealed incidental findings in the thyroid gland, including nodules, were recorded, together with the sizes and characteristics of the findings. The Japan Association of Breast and Thyroid Sonology (JABTS) guidelines were used for classification. The rate of descriptions of these findings in the radiographic interpretation reports were also examined. Of the 1,135 patients examined, 326 (28.7%) had several types of incidental findings. In particular, 169 (14.9%) of the 1,135 patients had nodules >5 mm in diameter, for which further careful examination is recommended in the JABTS guideline. The description rate for nodules >5 mm in diameter in the radiographic interpretation reports was 30.8% (52/169 patients), of whom 17.3% (9/52 patients) were referred to the endocrinology department for further careful examination. Incidental findings in the thyroid gland were relatively common on CT images of the oral and maxillofacial region. Oral radiologists tend to focus specifically on the oral and maxillofacial region during diagnosis on oral and maxillofacial CT images, but should pay the same careful attention to observe adjacent regions, such as the thyroid gland.

DOI： 10.3892/ol.2020.11298

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Oropharyngeal adenoid cystic carcinoma invading the mandibular bone through the mandibular foramen. Reviewed

Yohei Takeshita, Shunsuke Okada, Miki Hisatomi, Hidenobu Matsuzaki, Hotaka Kawai, Yohei Noda, Jun Murakami, Mariko Fujita, Hitoshi Nagatsuka, Yoshinobu Yanagi, Junichi Asaumi

Oral radiology   35 ( 3 )   335 - 340   2019.9

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

Adenoid cystic carcinoma (ACC) is a rare epithelial tumor of the head and neck region, and one of the most common malignant tumors of the salivary glands. ACC is a slow-growing tumor characterized by perineural invasion and often has a high-recurrence rate. We describe a case of oropharyngeal ACC invading the mandibular bone through the mandibular foramen that showed a rare pattern of origin and invasion. A 70-year-old woman complained of noise and pain around the right temporomandibular joint. Osteomyelitis was suspected on the initial imaging examinations, although the findings were slightly atypical. However, a mass was observed in the right oropharyngeal wall on subsequent imaging examinations, and mandibular bone invasion, rather than osteomyelitis, was additionally suspected. The mass in the right oropharyngeal wall and right mandible was surgically excised. On postoperative histopathological examination, the mass was finally diagnosed as ACC. As tumor cells were also observed around the inferior alveolar nerve, mandibular bone invasion through the mandibular foramen was suspected. An oropharyngeal ACC invading the mandibular bone through the mandibular foramen is extremely rare. The present case suggests that bone invasion should be considered carefully with several imaging examinations when a malignant tumor such as ACC is observed around the jaw bone.

DOI： 10.1007/s11282-018-0359-3

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透明根管模型歯における根管充填の評価法に関する検討 Reviewed

松崎 久美子, 大原 直子, 澁谷 和彦, 横山 章人, 岡田 俊輔, 村上 純, 久富 美紀, 浅海 淳一, 吉山 昌宏

岡山歯学会雑誌   38 ( 1 )   11 - 18   2019.6

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Language：Japanese   Publisher：岡山歯学会  

歯学部学生の臨床前基礎実習において透明根管模型歯は、全ての学生が同一条件下で実習を行えることや、根管治療における各ステップを目視できる等の利点がある。今回、本学歯学部4年次生47名が象牙質歯髄複合体診断・治療学実習の実技試験で根管充填を行った透明根管模型歯について、視診による評価と、デジタルX線画像のモニタ上での視診による評価、およびデジタルX線画像を画像解析ソフト(ImageJ)により解析した評価を行い、各評価法の妥当性について比較検討した。その結果、画像解析ソフトで解析する方法は成績の過小評価を防ぐうえで有用であり、より客観的な評価が可能と考えられた。

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Fourth molar: A retrospective study and literature review of a rare clinical entity. Reviewed International journal

Babatunde O Bamgbose, Shunsuke Okada, Miki Hisatomi, Yoshinobu Yanagi, Yohei Takeshita, Zahrau Saleh Abdu, Edugie J Ekuase, Jun-Ichi Asaumi

Imaging science in dentistry   49 ( 1 )   27 - 34   2019.3

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：KOREAN ACAD ORAL & MAXILLOFACIAL RADIOLOGY  

Purpose: The prevalence of supernumerary teeth has been reported to be between 0.1% and 3.8%. The aim of this study was to determine the prevalence, clinical significance, and associated pathologies of fourth molars based on a retrospective study and a literature review. Materials and Methods: A 5-year retrospective prevalence study was conducted at the Department of Oral Diagnosis and Dentomaxillofacial Radiology of Okayama University Hospital, Okayama, Japan. The study involved extracting data from the digital records of patients from January 1, 2013 through December 31, 2017. The sampling frame included all patients who had panoramic radiographs, cone-beam computed tomography (CT), and multislice CT images during the period under review. Results: A total of 26,721 cases were reviewed and 87 fourth molars were identified. The prevalence of fourth molars in the 5-year study at Okayama was calculated as 0.32%. The mean age of patients with a fourth molar was 30.43 years, and the male-to-female ratio was 1:0.98. The vast majority of cases were in the maxilla (92%) and had normal shapes (89.7%); furthermore, 82.8% of cases were unerupted. Conclusion: The prevalence of fourth molars in the study population was found to be 0.32%, and fourth molars occurred with approximately equal frequency in males and females. Fourth molars were more common in the maxilla and were predominantly unerupted and small.

DOI： 10.5624/isd.2019.49.1.27

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Assessment of MRI findings and clinical symptoms in patients with temporomandibular joint disorders. Reviewed International journal

Risa Matsubara, Yoshinobu Yanagi, Kazuhiro Oki, Miki Hisatomi, Karina Cp Santos, Babatunde O Bamgbose, Mariko Fujita, Shunsuke Okada, Shogo Minagi, Junichi Asaumi

Dento maxillo facial radiology   47 ( 4 )   20170412 - 20170412   2018.5

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BRITISH INST RADIOLOGY  

OBJECTIVES: To investigate the correlations among various temporomandibular joint (TMJ) findings on MRI and the relationships between MRI findings and symptoms. METHODS: 425 patients (850 TMJs) with temporomandibular joint disorders (TMDs) who underwent MRI were enrolled. Oblique sagittal proton density-weighted and T2 weighted images in open- and closed-mouth positions were evaluated. MRI findings included disc configuration, disc position, condylar morphology, bone marrow pattern, and joint effusion. Symptoms included TMJ pain, TMJ noise, and limitation of mouth opening. For statistical analyses, Spearman's rank correlation coefficient and logistic regression analysis were applied. RESULTS: Folded disc, disc displacement without reduction (DDWOR), and osteophytes had significant negative correlations with other normal MRI findings (p < 0.01). DDWOR and marrow edema were associated with TMJ pain. Conversely, osteophytes [odds ratio (OR): 0.52; 95% CI (0.30-0.90)] and combination-type condylar degeneration [OR: 0.45; 95% CI (0.24-0.83)] were associated with decreased risk of TMJ pain. Condylar flattening was positively associated with TMJ noise [OR: 5.25; 95% CI (1.44-19.07)] and negatively associated with limitation of mouth opening [OR: 0.34; 95% CI (0.11-0.99)]. High-grade joint effusion was significantly associated with TMJ pain and noise. CONCLUSIONS: DDWOR and high-grade joint effusion (an indicator of inflammation in the articular cavity) were associated with TMD symptoms. This finding suggests that treatment strategy for DDWOR and decreasing inflammation might lessen clinical TMD symptoms. Condylar degeneration was not associated with indicators of inflammation or TMJ symptoms. These results suggest that patients with TMD symptoms should undergo initial MRI to allow rapid selection of appropriate therapies.

DOI： 10.1259/dmfr.20170412

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Incidental finding of papillary thyroid carcinoma on CT examination of mandibular lesion: Case report. Reviewed International journal

Irfan Sugianto, Yoshinobu Yanagi, Hidenobu Konouchi, Miki Hisatomi, Shunsuke Okada, Babatunde O Bamgbose, Junichi Asaumi

Molecular and clinical oncology   8 ( 1 )   183 - 187   2018.1

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPANDIDOS PUBL LTD  

The number of significant incidental findings identified on radiographic examinations has increased. In total, 169 patients, 87 males and 82 females, with a mean age of 67.3 years (range, 17-92 years), as well as 65 patients (38.5%), 43 (66.2%) female and 22 (33.8%) male had abnormal findings in the thyroid for one year in our institution. Thyroid nodules are the most common incidental findings on oral and maxillofacial evaluations. Computed tomography (CT) and magnetic resonance imaging (MRI) examination are frequently used to detect thyroid abnormality. The present study reported a case of papillary thyroid carcinoma (PTC) detected following CT and MRI examination of a mandibular lesion. The CT examination of the oral and maxillofacial region included the thyroid, which must be examined carefully to detect various diseases, including PTC. Collaboration between radiologists and clinicians is important to manage these incidental findings.

DOI： 10.3892/mco.2017.1478

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PubMed

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Diagnostic Value of Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging for Multilocular Ameloblastoma Reviewed

Irfan Sugianto, Hironobu Konouchi, Yohei Takeshita, Shunsuke Okada, Risa Matsubara, Miki Hisatomi, Jun Murakami, Babatunde O. Bamgbose, Yoshinobu Yanagi, Junichi Asaumi

JOURNAL OF HARD TISSUE BIOLOGY   27 ( 4 )   275 - 280   2018

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：JOURNAL HARD TISSUE BIOLOGY  

Contrast-enhanced (CE)-MR image is useful to distinguish cystic and solid portions on multilocular lesion, however, the CE-MR examination is contraindicated in patients with kidney disease. Fluid-attenuated inversion recovery (FLAIR) image is one of methods which signal of fluid is suppressed. This study investigated qualitatively and quantitatively whether FLAIR images were useful for detecting and differentiating cystic and solid portions of multilocular ameloblastomas. We retrospectively reviewed 11 cases of multilocular ameloblastoma. FLAIR and short Ti inversion recovery (STIR) sequences were performed in all cases. CE-MR images in 10 cases, and T1-weighted images (T1WI) in 7 cases. FLAIR, STIR, CE-MR, and T1WI images were visually evaluated (qualitative analysis). Signal-to-noise ratio (SNR) of cystic and solid portions were measured and compared among the images of all sequences (quantitative analysis). FLAIR imaging could detect cystic portions with very low SI in all cases because cystic fluid was well suppressed on the images, and the solid portion showed intermediate SI. On some STIR images, the solid portion was masked by the markedly high SI of the cystic fluid. CE-T1WI and CE-FLAIR images showed no enhancement of the cystic portion but enhancement of the solid portion. On FLAIR image, SNR of solid was higher than cystic portion (p < 0.05). Cystic and solid portions of a lesion could be detected and distinguished on FLAIR imaging. FLAIR images are thus useful for diagnosing multilocular ameloblastoma when CE-MR cannot be performed.

DOI： 10.2485/jhtb.27.275

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Scopus

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頭頸部癌マウスモデルを用いた分子イメージングによる抗癌剤セツキシマブ感受性の評価

岡田 俊輔

岡山歯学会雑誌   36 ( 1 )   1 - 8   2017.6

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Authorship：Lead author   Language：Japanese   Publisher：岡山歯学会  

腫瘍の増殖能や転移能に関与する生体内分子を標的とした陽電子断層撮影法(PET)のプローブを作製し、腫瘍の機能的な病態を画像上で予測することを目的とした。実験動物には7週齢BALB/cAJcl-nu/nuヌードマウスを用いた。PETプローブの作製、PET撮像および画像解析、ガンマカウンターを用いた%ID/g tissue値の計測、上皮成長因子受容体(EGFR)発現の免疫組織学的検討を行った。その結果、頭頸部癌に用いられる抗癌剤であるセツキシマブを89Zrで標識したものをPETプローブとして用いることで、EGFRの発現を可視化し、頭頸部癌のセツキシマブ感受性の評価を画像上で非侵襲的に行うことが可能となった。放射性核種の選択によっては、診断のみならず治療に応用できる可能性が考えられた。臨床応用を考える際には、放射性核種の半減期やプローブの代謝経路を考慮し、腫瘍部位以外での被曝についても検討していく必要があると考えられた。

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Diagnostic value of MR imaging for dentigerous cysts Reviewed

Hironobu Konouchi, Jun-ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Emiko Saito Arita, Plauto Christopher Aranha Watanabe, Jun Murakami, Teruhisa Unetsubo, Mariko Fujita, Shunsuke Okada, Hidenobu Matsuzaki, Toshihiko Takenobu, Toru Wakasa

ORAL RADIOLOGY   30 ( 1 )   13 - 19   2014.1

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

It is known that the magnetic resonance (MR) imaging features of dentigerous cysts (DCs) are the same as those of other cysts. The cavities of DCs generally show low signal intensity (SI) on T1-weighted imaging (T1WI). However, in our experience, DCs often show high SI on T1WI, rendering them difficult to distinguish from keratocystic odontogenic tumors (KCOTs). In this study, we evaluated seven cases of DC and 23 cases of KCOT to assess whether MR imaging can provide additional information for the differential diagnosis of DC and KCOT.Two trials were evaluated. The first trial was an analysis of the cystic cavity SI on T1WI. To compare the SI between patients, we performed T1WI with contrast (T1c). The second trial analyzed the SI uniformity (U (I )) pound on T1WI, T2-weighted imaging (T2WI), and short inversion time inversion recovery (STIR) images of the cystic cavity, because it has been reported that an MR imaging feature of KCOT is heterogeneous SI. Statistical analyses were performed using the Mann-Whitney U test and a receiver operating characteristic (ROC) curve.The T1c values of DCs were significantly higher than those for KCOTs. The U (I ) pound values on T1WI and STIR images were significantly higher for DCs than for KCOTs. The T1c cutoff values (0.66 and 0.84) and U (I ) pound cutoff values for T1WI (82.1 %) and STIR images (79.8 %) were determined from the ROC analyses.T1c and U (I ) pound values provide useful additional information for the differential diagnosis of DC and KCOT.

DOI： 10.1007/s11282-013-0128-2

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