Faculty Profiles - YAMAMOTO Hideki

Papers - YAMAMOTO Hideki

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Dual analyses of DNA-seq and RNA-seq identified two independent transcripts caused by a single nucleotide variant of MUTYH c.934-2A>G in advanced colon cancer Reviewed

Yamamoto H, Hinoi T, Wakatsuki T, Miyabe I, Yamamoto G, Kakuta M, Zaitsu J, Kuraoka K, Taniyama K, Akagi K

The OFFICIAL JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE 68 ( 12 ) 973 - 979 2020.12

CYP11B1/B2キメラ遺伝子を確認した家族性アルドステロン症小児例

中野靖浩, 岩田菜穂子, 長谷川高誠, 越智可奈子, 山本紘一郎, 高瀬了輔, 長谷川功, 堀口繁, 山本英喜, 平沢晃, 大塚文男

日本内分泌学会雑誌 96 ( 2 ) 535 - 535 2020.10

遺伝性腫瘍-最新情報と今後の方向性がん遺伝子パネル検査によるがん個別化医療と遺伝性腫瘍への実効果

山本英喜, 久保寿夫, 冨田秀太, 遠西大輔, 豊岡伸一, 平沢晃

日本癌学会総会記事 79回 S21 - 5 2020.10

A case of Turcot's syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report. Reviewed International journal

Shintaro Akabane, Takao Hinoi, Kiwamu Akagi, Hideki Yamamoto, Haruki Sada, Yosuke Shimizu, Wataru Shimizu, Takeshi Sudo, Takashi Onoe, Kohei Ishiyama, Takahisa Suzuki, Hirofumi Tazawa, Naoto Hadano, Toshihiro Misumi, Masato Kojima, Haruna Kubota, Daiki Taniyama, Kazuya Kuraoka, Hirotaka Tashiro

BMC medical genetics 21 ( 1 ) 141 - 141 2020.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Lynch syndrome (LS), which is known as a hereditary cancer syndrome, is distinguished by microsatellite instability, represented by the altered number of repetitive sequences in the coding and/or non-coding region. Immunohistochemical staining (IHC) of DNA mismatch repair (MMR) proteins (e.g., MLH1, MSH2, MSH6, and PMS2) has been recognized as an useful technique for screening of LS. Previous study has shown that the assessment of IHC, however, requires specific caution due to variable staining patterns even without germline mutations in MMR genes. CASE PRESENTATION: A 48-year-old man, who had been treated for anaplastic astrocytoma, was referred to our department for the precise examination of progressing anemia. Whole-body examination revealed two advanced carcinomas in descending colon and stomach. A hypo-vascular mass lesion was detected in liver as well. Pathological diagnosis (on surgical specimens) was poorly differentiated adenocarcinoma in descending colon, moderately differentiated tubular adenocarcinoma in stomach, and liver metastasis, which is possibly from colon. It was suspected that this case would be Turcot's syndrome-type-1 due to its specific family history having two cases of colon cancer within the second relatives. Pathogenic frameshift mutations in codon 618 of MLH1 gene was identified. Immunohistochemical analyses (IHC) demonstrated complete loss of MLH1 immuno-expression as well as of PMS2 except for those in brain tumor. Although frameshift mutation was not found in MSH6 gene, histological expression of MSH6 was patchy in primary colon carcinoma and was completely lost in the metastatic site in liver. MSH6 expression in gastric carcinoma, a coincidental cancer in this case, was intact. An abnormal (C)8 region was identified by the cloned PCR of colon and liver tumors but not from gastric cancer. Frameshift mutation in a (C)8 tract in exon 5 of the MSH6 gene was also detected in liver metastasis. CONCLUSION: This case supports a plausible mechanism, proposed by a previous literature, for the reduced expression of MSH6 in a somatic mutation manner, which might preferentially happen in colon cancer rather than in stomach carcinoma in MLH1/PMS2-deficient type of Turcot's syndrome type 1.

DOI： 10.1186/s12881-020-01079-x

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ゲノム医療におけるエキスパートパネル【がんゲノム医療中核拠点病院でのエキスパートパネル】岡山大学のエキスパートパネル

柳井広之, 都地友紘, 谷口恒平, 西田賢司, 井上博文, 松岡博美, 平沢晃, 河内麻里子, 山本英喜, 冨田秀太, 遠西大輔

病理と臨床 38 ( 6 ) 527 - 530 2020

Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability: a case report and literature review Reviewed

Nozomi Karakuchi, Manabu Shimomura, Kazuhiro Toyota, Takao Hinoi, Hideki Yamamoto, Seiji Sadamoto, Koichi Mandai, Hiroyuki Egi, Hideki Ohdan, Tadateru Takahashi

World Journal of Surgical Oncology 17 ( 1 ) 2019.12

CD204-Positive Tumor-associated Macrophages Relate to Malignant Transformation of Colorectal Adenoma

DAIKI TANIYAMA, KIYOMI TANIYAMA, KAZUYA KURAOKA, HIDEKI YAMAMOTO, JUNICHI ZAITSU, AKIHISA SAITO, NAOYA SAKAMOTO, KAZUHIRO SENTANI, NAOHIDE OUE, WATARU YASUI

Anticancer Research 39 ( 6 ) 2767 - 2775 2019.6

Low grade dysplasiaを伴う胃底腺ポリープの１例

在津潤一, 倉岡和矢, 山本英喜, 斉藤彰久, 谷山清己

診断病理 36 ( 2 ) 87 - 93 2019

Overexpression of topoisomerase II alpha protein is a factor for poor prognosis in patients with luminal B breast cancer

Hideo Shigematsu, Shinji Ozaki, Daisuke Yasui, Hideki Yamamoto, Junichi Zaitsu, Daiki Taniyama, Akihisa Saitou, Kazuya Kuraoka, Taizo Hirata, Kiyomi Taniyama

Oncotarget 9 ( 42 ) 26701 - 26710 2018.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Impact Journals LLC

Background: The prognostic value and the best method of testing of topoisomerase II alpha (TOP2A) status have not been established in modern tailored therapy based on breast cancer subtype. Results: The frequencies of TOP2A overexpression and TOP2A amplified were 55.8% and 9.5%, respectively. TOP2A overexpression correlated strongly with nonluminal A subtype (χ2-test, p &lt
0.001). TOP2A overexpression was significantly associated with relapse-free survival in luminal B breast cancer (n = 316
log rank test, p &lt
0.001) but not in other breast cancer subtypes. Cox regression analysis showed that TOP2A overexpression is a significant prognostic factor in luminal B breast cancer (hazard ratio (HR) 4.00, 95% confidence interval (CI) 1.65-9.54, p = 0.002). TOP2A amplified was recognized in HER2 positive breast cancer (p &lt
0.001). In HER2 positive breast cancer, TOP2A amplified (HR 0.30, 95% CI 0.085-1.07, p = 0.063) appeared to be a better prognostic factor. Conclusion: In modern tailored therapy, TOP2A overexpression can be a poor prognostic factor in luminal B breast cancer. In contrast, TOP2A amplified could be a better prognostic factor in HER2 positive breast cancer. Materials and methods: Between May 2005 and April 2015, a total of 643 consecutive non-metastatic invasive breast cancers were evaluated for TOP2A amplified using fluorescence in situ hybridization analysis (FISH) and for TOP2A overexpression using the immunohistochemistry assay. FISH ratios of 2 or higher were designated as TOP2A amplified, and TOP2A staining &gt
10% was defined as TOP2A overexpression. The prognostic values of TOP2A amplified and TOP2A overexpression were retrospectively evaluated.

DOI： 10.18632/oncotarget.25468

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当院における子宮頸部異形成に対するCO2レーザー蒸散術の治療成績

三浦聡美, 澤崎隆, 高畑敬之, 中村紘子, 藤澤宏樹, 菅亜里紗, 安村奈緒子, 吉田美帆, 佐伯由美, 戸田環, 山本英喜, 在津潤一, 谷山大樹, 齋藤彰久, 倉岡和矢, 谷山清己

広島県臨床細胞学会誌 39 41 - 44 2018

当院における泌尿器細胞診新報告様式導入に伴う報告状況と異型細胞所見の検討

佐伯由美, 倉岡和矢, 安村奈緒子, 藤澤宏樹, 菅亜里紗, 吉田美帆, 戸田環, 谷山大樹, 在津潤一, 山本英喜, 齋藤彰久, 谷山清己

広島県臨床細胞学会誌 39 13 - 19 2018

Autocrine VEGF isoforms differentially regulate endothelial cell behavior Reviewed

Yamamoto, H, Rundqvist, H, Branco, C, Johnson, R.S

Frontiers in Cell and Developmental Biology Sep 21 ( 4:99 ) 2016

Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion Reviewed

Nobuaki Fujikuni, Hideki Yamamoto, Kazuaki Tanabe, Yutaka Naito, Naoya Sakamoto, Yuka Tanaka, Kazuyoshi Yanagihara, Naohide Oue, Wataru Yasui, Hideki Ohdan

CANCER SCIENCE 105 ( 11 ) 1411 - 1420 2014.11

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

CD24 is a heavily glycosylated cell surface protein that is expressed in putative stem cells and is overexpressed in various human malignancies, yet the significant roles of CD24 in gastric cancer development are still elusive. We investigated the involvement of CD24 in gastric cancer aggressiveness, which is attributed to its heterogeneity. Cultured gastric cancer cells showed diverse expression patterns in CD24, whereas other defined cell surface markers, such as CD44 and CD133, were homogenous. Purely sorted CD24-negative gastric cancer cells showed strong alteration into the CD24-positive cell type in an autochthonous manner, and reached to steady expression levels. Our clinicopathological study revealed that CD24 positivity was an independent prognostic factor in both intestinal and diffuse types of gastric cancer. CD24 expression was correlated with the advanced stages, invasiveness, and lymph node metastasis of gastric cancer. Silencing of CD24 in cultured cells significantly decreased cell migration and invasion. Hypoxic treatment upregulated CD24 expression, and simultaneously induced cell motility and invasion of gastric cancer cells. Hypoxic treatment-induced CD24 expression was significantly attenuated by knockdown of hypoxia-inducible transcription factors. These data suggest that CD24-negative cells are capable of gaining cell motility and invasiveness through the induction of CD24, which is mediated by hypoxia. CD24 would be an attractive marker to define not only the heterogeneity but also the aggressiveness of gastric cancer cells. The mechanisms by which hypoxia induces CD24 expression would also be a potential therapeutic target for gastric cancer.

File： Fujikuni_et_al-2014-Cancer_Science.pdf

DOI： 10.1111/cas.12522

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Triple-tube-ostomy: A novel technique for the surgical treatment of iatrogenic duodenal perforation Reviewed

Nobuaki Fujikuni, Kazuaki Tanabe, Hideki Yamamoto, Takahisa Suzuki, Noriaki Tokumoto, Hideki Ohdan

Case Reports in Gastroenterology 5 ( 3 ) 672 - 679 2011.9

Language：English Publishing type：Research paper (scientific journal)

Although duodenal perforation is currently an infrequent complication of medical procedures, its incidence in the future predictably will increase as endoscopic treatment of duodenal neoplasms becomes more frequently used. In some cases, duodenal perforation is difficult to treat even surgically. We report here a novel technique called 'triple-tube-ostomy' for the treatment of iatrogenic duodenal perforation. Since November 2009, there have been three cases of iatrogenic perforation of the duodenum, due to various causes, which we have treated with our novel technique. The main principles of the technique are biliary diversion, decompression of the duodenum, and early enteral nutrition. All patients who underwent the triple-tube-ostomy procedure had good postoperative courses, with few complications. The novel surgical technique we describe in this report is safe, reliable, easy to learn and perform, and led to a good postoperative course in all cases where we performed it. Copyright © 2011 S. Karger AG.

DOI： 10.1159/000335742

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99mTc-MIBIシンチグラム陰性原発性副甲状腺機能亢進症に対して術中intact-PTH測定により内視鏡補助下手術をしえた１例 Reviewed

山本英喜, 内田一徳, 春田直樹, 小川喜輝, 清水一雄

日本内視鏡外科学会雑誌 16 ( 3 ) 317 - 322 2011

Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis

Kazuaki Tanabe, Takahisa Suzuki, Noriaki Tokumoto, Hideki Yamamoto, Kazuhiro Yoshida, Hideki Ohdan

World Journal of Surgical Oncology 8 ( 1 ) 2010.12

Thoracoscopic-assisted repair of a bochdalek hernia in an adult: a case report. Reviewed

Tokumoto N, Tanabe K, Yamamoto H, Suzuki T, Miyata Y, Ohdan H

Journal of medical case reports 4 366 2010.11

Preliminary trial of adjuvant surgery for advanced gastric cancer Reviewed

T. Suzuki, K. Tanabe, J. Taomoto, H. Yamamoto, N. Tokumoto, K. Yoshida, H. Ohdan

Oncology Letters 1 ( 4 ) 743 - 747 2010.7

Language：English Publishing type：Research paper (scientific journal)

In patients with stage IV gastric cancer, systemic chemotherapy is the key treatment. Combination chemotherapy (cis-diamminedichloride platinum plus S-1 and docetaxel plus S-1) results in long-term survival in clinical practice. In selected cases, additional (adjuvant) surgery may result in further long-term survival. This study aimed to evaluate the effcacy of adjuvant surgery following the response to chemotherapy for advanced gastric cancer. Based on response to chemotherapy, the indications for adjuvant surgery (surgery after the response to chemotherapy) are that resection is expected to be curative rather than palliative, provided that no other distant metastases occur. The study included 20 advanced gastric cancer patients who had undergone gastrectomies after the response to the combination chemotherapy of docetaxel and S-1, between September 2003 and December 2008 at Hiroshima University Hospital. At a median follow-up of 980 days, the median overall survival was 855 days. A 2- and 3-year survival was observed in 80 and 54.9% of patients, respectively, following macroscopic curative surgery. In the palliative group, the median overall survival was 510 days, but a 3-year survival was not observed. In the partial response group, the median overall survival was 865 days and a 3-year survival was observed in 37% of patients. One-year survival was not observed in the stable disease group. The patient survival in the partial response group was statistically more prolonged than in the stable disease group. The median overall survival in patients with liver metastasis was 865 days, while that in patients with peritoneal dissemination was 510 days. In conclusion, adjuvant surgery may be effective in gastric cancer patients diagnosed as stage IV by means of liver or distant lymph node metastasis, except in cases of peritoneal dissemination.

DOI： 10.3892/ol_00000130

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Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase Reviewed

H. Yamamoto, N. Oue, A. Sato, Y. Hasegawa, H. Yamamoto, A. Matsubara, W. Yasui, A. Kikuchi

ONCOGENE 29 ( 14 ) 2036 - 2046 2010.4

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Wnt5a is a representative ligand that activates the beta-catenin-independent pathway in Wnt signaling. Although it has been reported that abnormal activation of the Wnt/beta-catenin-dependent pathway is often observed in human prostate cancer, the involvement of the b-catenin-independent pathway in this cancer is unclear. Abnormal expression of Wnt5a and beta-catenin was observed in 27 (28%) and 49 (50%) of 98 prostate cancer cases, respectively, by immunohistochemical analyses. Simultaneous expression of Wnt5a and b-catenin was observed in only five cases, suggesting their exclusive expression. The positive detection of Wnt5a was correlated with high Gleason scores and biochemical relapse of prostate cancer, but that of b-catenin was not. Knockdown and overexpression of Wnt5a in human prostate cancer cell lines reduced and stimulated, respectively, their invasion activities, and the invasion activity required Frizzled2 and Ror2 as Wnt receptors. Wnt5a activated Jun-N-terminal kinase through protein kinase D (PKD) and the inhibition of PKD suppressed Wnt5a-dependent cell migration and invasion. In addition, Wnt5a induced the expression of metalloproteinase-1 through the recruitment of JunD to its promoter region. These results suggest that Wnt5a promotes the aggressiveness of prostate cancer and that its expression is involved in relapse after prostatectomy. Oncogene (2010) 29, 2036-2046; doi: 10.1038/onc.2009.496; published online 18 January 2010

File： Wnt5a & PCa; Yamamoto H et al; Oncogene 2010 front.pdf

DOI： 10.1038/onc.2009.496

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外観上傷のない腹腔鏡下胆嚢摘出術単孔式腹腔鏡下手術 Reviewed

山本英喜, 内田一徳, 大下彰彦, 小川喜輝, 春田直樹, 大段秀樹

広島医学 63 ( 7 ) 505 - 508 2010

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Papers - YAMAMOTO Hideki