Faculty Profiles - MAEDA Yoshinobu

MISC - MAEDA Yoshinobu

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Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization International journal

T Kozuka, K Ikeda, T Teshima, K Kojima, K Matsuo, A Bessho, K Sunami, Y Hiramatsu, Y Maeda, T Noguchi, K Yamamoto, N Fujii, T Imai, K Takenaka, K Shinagawa, F Ishimaru, K Niiya, N Koide, M Tanimoto, M Harada

TRANSFUSION 42 ( 11 ) 1514 - 1522 2002.11

Language：English Publisher：AMER ASSOC BLOOD BANKS

Background: Enumeration of CD34+ cells in peripheral blood (PB) before apheresis predicts the number of CD34+ cells collected, although flow cytometric techniques used are complex and expensive. In an attempt to determine the optimal timing for peripheral blood progenitor cell (PBPC) collection, the usefulness of circulating immature cell (CIC) counts in PB was evaluated.
Study design and methods: CIC counts in PB and CD34+ cell counts in the apheresis product from 249 collections were assessed, and the relationship between these two parameters was evaluated by with the Pearson rank correlation analysis, the Fisher exact test, and the U-test.
Results: CIC counts were correlated significantly with the number of CD34+ cells per kg of patient's body weight in the apheresis product (Pearson rank correlation analysis: r=0.635, p<0.0001). When a level of 1x10(9) CICs per L was selected as a cutoff value, the sensitivity and specificity for collecting more than 1x10(6) CD34+ cells per kg of body weight were 75.7 and 85.5 percent, respectively.
Conclusion: The present study strongly suggests that the number of CICs in PB may estimate the number of CD34+ cells collected. The data indicate that CIC counts above 1x10(9) per L can be used as a good predictor for PBPC collections containing more than 1x10(6) CD34+ cells per kg of body weight in a single apheresis procedure.

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Ureteric obstruction by retroperitoneal lymphoplasmacytic lymphoma International journal

Y Maeda, Y Nawa, K Tanimoto, K Oshima, M Hara

AMERICAN JOURNAL OF HEMATOLOGY 71 ( 3 ) 238 - 238 2002.11

Interleukin 18 preserves a perforin-dependent graft-versus-leukemia effect after allogeneic bone marrow transplantation International journal

P Reddy, T Teshima, G Hildebrandt, U Duffner, Y Maeda, KR Cooke, JLM Ferrara

BLOOD 100 ( 9 ) 3429 - 3431 2002.11

Language：English Publisher：AMER SOC HEMATOLOGY

We have recently shown that early administration of interleukin 18 (IL-18) after bone marrow transplantation (BMT) attenuates acute graft-versus-host disease (GVHD) in a lethally irradiated parent into F1 (B6-->B6D2F1) BMT model. In this study, we investigated whether IL-18 can maintain graft-versus-leukemia (GVL) effect in this context. B6D2F1 mice received transplants of T-cell-depleted (TCD) bone marrow (BM) and splenic T cells from either syngeneic (H2(b/d)) or allogeneic B6 (H2(b)) donors. Recipient mice were treated with recombinant murine IL-18 or the control diluent. Initial studies demonstrated that IL-18 treatment did not affect the proliferative responses or the cytolytic effector functions of T cells after BMT. In subsequent experiments, animals also received host-type P815 mastocytoma cells at the time of BMT. All syngeneic BM transplant recipients died from leukemia by day 18. The allogeneic BM transplant recipients effectively rejected their leukemia regardless of treatment and IL-18 significantly reduced GVHD-related mortality. Examination of the cytotoxic mechanisms with perforin-deficient donor T cells demonstrated that perforin is critical for the GVL effect. Taken together these data demonstrate that IL-18 can attenuate acute GVHD without impairing the in vitro cytolytic function or the in vivo GVL activity after allogeneic BMT.

DOI： 10.1182/blood-2002-04-1252

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Peripheral blood circulating immature cell counts predict CD34+ cell yields in chemotherapy- and granulocyte colony-stimulating factor-induced stem cell mobilization.

K Ikeda, T Kozuka, T Teshima, K Kojima, K Matsuo, A Bessho, K Sunami, Y Hiramatsu, Y Maeda, T Noguchi, K Yamamoto, N Fujii, T Imai, K Takenaka, K Shinagawa, F Ishimaru, K Niiya, N Koide, M Tanimoto, M Harada

BLOOD 100 ( 11 ) 412B - 412B 2002.11

Differentiation of monoblastic cell line UG3 into leukemic dendritic cells International journal

N Fujii, T Ikeda, K Ikeda, A Hiraki, K Kawakami, K Masuda, Y Maeda, K Hatake, K Motoyoshi, M Harada, M Tanimoto

INTERNATIONAL JOURNAL OF ONCOLOGY 21 ( 3 ) 617 - 620 2002.9

Language：English Publisher：PROFESSOR D A SPANDIDOS

Dendritic cells (DCs) are known to be generated from leukemic clone from patients with acute and chronic leukemia when cultured in the presence of combination of granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha) and interleukin-4. However, there have been few reports that showed DCs could be effectively differentiated from human leukemia cell lines. In this study, we have shown that a human monoblastic cell line, UG3, was inducible to differentiate into DCs in the presence of GM-CSF and TNF-alpha along monocyte-macrophage lineage. These DCs, consistently displayed dendritic morphology, phenotypes and allogeneic T-cell stimulating capacity. UG3 cells thus may represent a suitable model to further elucidate characteristics of DC differentiation.

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Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions

M Makita, Y Maeda, K Takenaka, K Shinagawa, K Sunami, Y Hiramatsu, N Fujii, F Ishimaru, K Ikeda, K Niiya, T Yoshino, M Harada

INTERNATIONAL JOURNAL OF HEMATOLOGY 76 ( 1 ) 94 - 97 2002.7

Language：English Publisher：CARDEN JENNINGS PUBL CO LTD

We describe a patient with progressive natural killer (NK) cell lymphoma who was treated successfully with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) followed by early cyclosporine (CsA) tapering and donor leukocyte infusion (DLI). Because the disease showed early resistance to conventional chemoradiotherapy, we performed high-close chemotherapy followed by allo-PBSCT. After achieving hematologic engraftment. the patient underwent early tapering of CsA and DLI in an attempt to induce a graft-versus-lymphoma effect. Although the disease was in a progressive state at the time of transplantation, complete remission was obtained after allo-PBSCT. As of this report. the patient has been well for more than 2 years.

DOI： 10.1007/BF02982726

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Extragonadal germ cell tumor with high serum levels of DU-PAN-2 International journal

Y Maeda, N Fujiwara, T Yoshino, K Kiura, H Ueoka, M Harada

JOURNAL OF UROLOGY 167 ( 1 ) 246 - 247 2002.1

Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation.

Saito T, Takenaka K, Shinagawa K, Matsuo K, Yoshino T, Kiura K, Niiya K, Harada M

Int J Hematol 75 332 - 334 2002

Predictive value of circulating immature cell counts in perpheral blood for timing of peripheral blood stem cell collection after granylocyte colony-stimulating factor plus chemotherapy-induced mobilization.

Kozuka T, Ikeda K, Teshima T, Kojima K, Matsuo K, Bessho A, Sunami K, Hiramatsu Y, Maeda Y, Noguchi T, Yamamoto K, Fujii N, Imai T, Takenaka K, Shinagawa K, Ishimaru F, Niiya K, Koide N, Tanimoto M, Harada M

Transfusion 42 1514 - 1522 2002

Cytomegalovirus enteritis after autologous periphiral blood stem cell transplantation

Kozuka T, Takenaka K, Shinagawa K, Masuda K, Ishihara t, Arimori Y, Fukunaga S, Maeda Y, Ishimaru F, Kiura K, Niiya K, Harada M

Ann Hematol 2001

Hepatic graft-versus-host disease prsenting as an acute hepatitis after allogeneic peripheral blood stem cell transplantation

Fujii N, Takenak K, Shinagawa K, Ikeda K, Sunami K, Hiramatsu Y, Matsuo K, Ishimaru F, Niiya K, Yoshino T, Hirabyashi N, Harada M

Bone Marrow Transplant 27 1007 - 1010 2001

G-CSF投与健常人ドナーからの末梢血幹細胞採取の経験(一般演題,日本アフェレシス学会第19回関西地方会抄録)

今井利, 小塚輝彦, 山本和彦, 藤井伸治, 前田嘉信, 中克斗, 品川克至, 池田和真, 原田実根, 角南一貴

日本アフェレシス学会雑誌 20 ( 1 ) 118 - 118 2001

High-dose chemotherapy with hematopoietic stem cell transplantation is effective for nasal and nasal-type CD56+ natural killer cell lymphomas.

Takenaka K, Shinagawa K, Maeda Y, Makita M, Kozuka T, Ashiba A, Yamamoto K, Fujii N, Nawa Y, Hiramatsu Y, Sunami K, Ishimaru F, Yoshimo T, Kiura K, Harada M

Leuk and Lymph 2001

Successful engraftment of allogeneic peripheral blood stem cell transplant after nonmyeloablative preparative regimen with cytarabine and cyclophosphamide: Report of 2 cases

N Fujii, Y Maeda, K Takenaka, K Shinagawa, T Imai, T Kozuka, K Ikeda, K Sunami, Y Hiramatsu, F Ishimaru, K Niiya, M Harada

INTERNATIONAL JOURNAL OF HEMATOLOGY 72 ( 4 ) 499 - 503 2000.12

Language：English Publisher：CARDEN JENNINGS PUBL CO LTD

We report our experience with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) following a nonmyeloablative conditioning regimen consisting of cytarabine (8 g/m(2)) and cyclophosphamide (120 mg/kg) in the treatment of 2 patients aged 50 and 55 years with refractory chronic myelomonocytic leukemia and chronic myeloid leukemia in accelerated phase, respectively. Our nonmyeloablative regimen was well tolerated by older patients at high risk of regimen-related toxicity by the conventional conditioning regimen but was immunosuppressive enough to achieve mixed chimerism. After allo-PBSCT, we monitored chimerism in these patients by fluorescence in situ hybridization using X- and Y-specific probes and polymerase chain reaction-based analysis of a variable number of tandem repeats. We found that full chimerism and graft-versus-leukemia (GVL) effects could be induced in these patients by donor lymphocyte infusions and withdrawal of post transplantation immunosuppressive therapy. Our observations suggest that a nonmyeloablative conditioning regimen can establish mixed chimerism and that donor lymphocyte infusion may induce GVL effects in older patients at high risk of regimen-related toxicity. Int J Hematol. 2000;72:499-503. (C)2000 The Japanese Society of Hematology.

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Allogeneic peripheral blood stem cell transplantation in 23 adult patients with hematologic malignancies: a single-center experience.

Takenaka K, Shinagawa K, Sunami K, Fujii N, Hiramatsu Y, Maeda Y, Nawa Y, Katayama Y, Teshima T, Ishimaru F, Kiura K, Ikeda K, Harada M

Inl J Hematol 2000

Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active epstein-barr virus infection.

Fujii N, Takenaka K, Hiraki A, Maeda Y, Ikeda K, Shinagawa K, Ashiba A, Munemasa M, Sunami K, Hiramatsu Y, Ishimaru F, Niiya K, Yoshino T, Harada M

Bone Marrow Transplant 2000

Histologic transformation of follicular lymphoma after allogeneic bone marrow transplantation.

Kojima K, Mannami T, Yoshino T, Kawasaki H, Sasaki K, Maeda T, Furuya K, Harada M, Hara M

Bone Marrow Transplant 2000

Recurrent idiopathic iridocyclitis after autologous peripheral blood stem cell transplantation followed by G-CSF administration for acute lymphoblastic leukemia.

Tsuchiyama, J, Imajo K, Sakaguchi, N, Yoshino, T, Suzaki, N, Kondo E, Takaba, S, Kawata, N, Okada, K, Maeda, T, Tomiyama, Y, Tsubota, T

Ann Hematol 2000

Monitoring of human herpesviruses after allogeneic peripheral blood stem cell transplantation and bone marrow transplantation.

Y Maeda, T Teshima, K Shinagawa, K Takenaka, F Ishimaru, K Ikeda, K Niiya, M Harada

BLOOD 92 ( 10 ) 282A - 283A 1998.11

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