Faculty Profiles - MAEDA Yoshinobu

Statin-independent prognosis of patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy

D. Ennishi, H. Asai, Y. Maeda, K. Shinagawa, K. Ikeda, M. Yokoyama, Y. Terui, K. Takeuchi, T. Yoshino, K. Matsuo, K. Hatake, M. Tanimoto

ANNALS OF ONCOLOGY 21 ( 6 ) 1217 - 1221 2010.6

Language：English Publisher：OXFORD UNIV PRESS

Background: A recent laboratory study indicated that statins impaired the antitumor effects of rituximab by inducing conformational changes in CD20. Although these findings raised significant concerns about statin use during rituximab treatment, their clinical significance is unclear.
Patients and methods: We conducted a retrospective study investigating the effects of statins on the prognosis of diffuse large B-cell lymphoma (DLBCL) treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP). Newly diagnosed DLBCL patients were analyzed (n = 256), including 35 patients taking statins.
Results: The 3-year progression-free survival rates were 84% and 73% (P = 0.38), while the overall survival rates were 89% and 78% (P = 0.28) for those patients treated with and without statins, respectively. After adjusting for the International Prognostic Index and serum cholesterol level, statin use was not associated with prognosis.
Conclusions: These results indicate that statins do not influence the clinical prognosis of DLBCL treated with RCHOP. Further studies with larger numbers of patients are warranted to confirm the prognostic significance of statins for patients with DLBCL receiving rituximab-containing chemotherapy.

DOI： 10.1093/annonc/mdp490

PHASE II STUDY OF SMILE CHEMOTHERAPY FOR NEWLY-DIAGNOSED STAGE IV, RELAPSED OR REFRACTORY EXTRANODAL NK/T-CELL LYMPHOMA, NASAL TYPE: NKTSG STUDY

Y. L. Kwong, M. Yamaguchi, Y. Maeda, C. Hashimoto, W. S. Kim, C. W. Suh, E. Sueoka, F. Ishida, K. Izutsu, R. Hyo, S. Nakamura, J. Suzumiya, K. Oshimi, R. Suzuki

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 95 119 - 120 2010.6

Cold agglutinin-induced acrocyanosis in a patient with subclinical chronic lymphocytic leukemia; a beneficial response to rituximab International journal

Yoshinori Shirafuji, Yoshinobu Maeda, Keiji Iwatsuki

EUROPEAN JOURNAL OF DERMATOLOGY 20 ( 3 ) 394 - 396 2010.5

劇症肝炎を発症し、同種造血幹細胞移植を施行したEBV関連NK/T細胞増殖症の2例

新谷大悟, 近藤正太郎, 遠西大輔, 青山一利, 久保西四郎, 近藤英生, 前田嘉信, 品川克至, 谷本光音

日本リンパ網内系学会会誌 50 106 - 106 2010.5

Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type: NKTSG study

M. Yamaguchi, Y. Kwong, Y. Maeda, C. Hashimoto, W. Kim, C. Suh, R. Hyo, S. Nakamura, K. Oshimi, R. Suzuki

JOURNAL OF CLINICAL ONCOLOGY 28 ( 15 ) 2010.5

Oral mucositis in patients receiving reduced-intensity regimens for allogeneic hematopoietic cell transplantation: comparison with conventional regimen International journal

Kanayo Takahashi, Yoshihiko Soga, Yumeno Murayama, Mika Udagawa, Hitomi Nishimoto, Yuko Sugiura, Yoshinobu Maeda, Mitsune Tanimoto, Shogo Takashiba

SUPPORTIVE CARE IN CANCER 18 ( 1 ) 115 - 119 2010.1

Language：English Publisher：SPRINGER

Severe oral mucositis induced by allogeneic hematopoietic cell transplantation (HCT) is associated with intolerable pain and risk of systemic bacteremia infection. Differences between conventional HCT and reduced-intensity regimens for allogeneic HCT (RIST) may influence the occurrence and severity of oral mucositis. Here, we evaluated oral mucositis in patients undergoing RIST and compared the results with those in conventional allogeneic HCT patients to facilitate predictive measures for mucositis.
A total of 127 consecutive patients undergoing HCT (conventional, 63; RIST, 64) were included in this study. Severity of oral mucositis during HCT period was evaluated daily. Differences in severity of mucositis among HCT types were analyzed. Use of morphine to control pain due to oral mucositis was evaluated in each HCT method.
The severity of oral mucositis was reduced in patients undergoing RIST. Worsening of oral mucositis was delayed in patients receiving RIST. Use of morphine to control pain due to oral mucositis was significantly decreased in patients undergoing RIST compared with those receiving conventional allogeneic HCT.
The severity of oral mucositis was reduced and the peak day of oral mucositis was delayed in RIST patients compared with those receiving conventional HCT.

DOI： 10.1007/s00520-009-0637-z

Oral mucositis in patients receiving reduced-intensity regimens for allogeneic hematopoietic cell transplantation: comparison with conventional regimen

Kanayo Takahashi, Yoshihiko Soga, Yumeno Murayama, Mika Udagawa, Hitomi Nishimoto, Yuko Sugiura, Yoshinobu Maeda, Mitsune Tanimoto, Shogo Takashiba

SUPPORTIVE CARE IN CANCER 18 ( 1 ) 115 - 119 2010.1

Language：English Publisher：SPRINGER

DOI： 10.1007/s00520-009-0637-z

Comparison of the incidence and pattern of interstitial lung disease during erlotinib and gefitinib treatment in Japanese Patients with non-small cell lung cancer, the Okayama Lung Cancer Study Group experience.

Hotta K, Kiura K, Takigawa N, Yoshioka H, Harita S, Kuyama S, Yonei T, Fujiwara K, Maeda T, Aoe K, Ueoka H, Kamei H, Umemura S, Moritaka T, Segawa Y, Kawai H, Bessho A, Kato K, Tabata M, Tanimoto M

J Thorac Oncol 5 ( 2 ) 179 - 184 2010

Prognostic analysis and a new risk model for Hodgkin lymphoma in Japan.

Itoh K, Kinoshita T, Watanabe T, Yoshimura K, Okamoto R, Chou T, Ogura M, Hirano M, Asaoku H, Kurosawa M, Maeda Y, Omachi K, Moriuchi Y, Kasai M, Ohnishi K, Takayama N, Morishima Y, Tobinai K, Kaba H, Yamamoto S, Fukuda H, Kikuchi M, Yoshino T, Matsuno Y, Hotta T, Shimoyama M

Int J Hematol 91 ( 3 ) 446 - 455 2010

合成レチノイドAm80によるTh1/Th17を介した慢性GVHD制御

西森久和, 前田嘉信, 杉山暖子, 小林孝一郎, 山筋好子, 近藤英生, 品川克至, 竹内賢吾, 谷本光音

日本造血細胞移植学会総会プログラム・抄録集 32nd 2010

Immunoglobulin G4 (IgG4)-positive or -negative ocular adnexal benign lymphoid lesions in relation to systemic involvement

Matsuo T, Ichimura K, Sato Y, Tanimoto Y, Kiura K, Kanazawa S, Okada T, Yoshino T

J Clin Exp Hematop 50 ( 2 ) 129 - 142 2010

Incidental Detection of Acute Lymphoblastic Leukemia on [(18)F] Fluorodeoxyglucose Positron Emission Tomography International journal

Daisuke Ennishi, Yoshinobu Maeda, Masami Niiya, Katsuji Shinagawa, Mitsune Tanimoto

JOURNAL OF CLINICAL ONCOLOGY 27 ( 36 ) e269 - e270 2009.12

Prediction of number of apheresis procedures necessary in healthy donors to attain minimally required peripheral blood CD34+cells International journal

Noriko Namba, Keitaro Matsuo, Shiro Kubonishi, Tomoko Kikuchi, Yoshinobu Maeda, Masami Niiya, Katsuji Shinagawa, Norio Koide, Kazuma Ikeda, Mitsune Tanimoto

TRANSFUSION 49 ( 11 ) 2384 - 2389 2009.11

Language：English Publisher：WILEY-BLACKWELL

BACKGROUND:
Allogeneic peripheral blood stem cell (PBSC) transplantation is widely performed as a curative therapy for hematopoietic malignancies. Donors for PBSC harvest (PBSCH) are usually healthy subjects and undergo granulocyte-colony-stimulating factor treatment and apheresis procedures. A considerable proportion of donors experience poor mobilization, necessitating additional harvesting or marrow collection or remobilization. Although some characteristics have been reported to correlate with poor mobilization, they may not be taken into account in selecting PBSC donors. To protect healthy donors, it is preferable to predict the number of apheresis procedures needed for PBSCH before the procedure is initiated.
STUDY DESIGN AND METHODS:
A retrospective cohort study of 83 subjects was conducted, using statistical models to predict the probability of obtaining a sufficient number of CD34+ cells (>= 2.0 x 106/kg) in the first to the third apheresis procedures and the probability of failure to obtain sufficient cells within three apheresis sessions. This study explored potential candidate factors in an ordinal probit regression analysis.
RESULTS:
Significant factors predicting successful PBSCH were donor age, donor sex, and body weight difference between donor and recipient. The predictive model showed good agreement with the observed number of apheresis sessions. Simulation tables are presented with this model.
CONCLUSION:
The statistical model developed to predict the number of apheresis procedures for PBSCH may be useful for planning PBSCH in clinical practice.

DOI： 10.1111/j.1537-2995.2009.02314.x

Autologous Versus Allogeneic Hematopoietic Stem Cell Transplantation (SCT) for Peripheral T-Cell Lymphomas (PTCLs): Japan and Korea Cooperative Study with 330 Patients

Sung-Won Kim, Sung-Soo Yoon, Ritsuro Suzuki, Hyeon Gyu Yi, Hiroatsu Ago, Masahiro Imamura, Atsushi Wake, Takashi Yoshida, Je-Jung Lee, Jin Seok Kim, Yoshinobu Maeda, Koji Izutsu, Hye Jin Kang, Je-Hwan Lee, Hugh Chul Kim, Junji Suzumiya, Yoshihiro Matsuno, Chul Woo Kim, Koji Nagafuji, Yoichi Takaue, Mine Harada, Chul Soo Kim

BLOOD 114 ( 22 ) 900 - 901 2009.11

The Impact of Outcome and Hepatic Toxicity in HCV-Infected Patients with Diffuse Large B-Cell Lymphoma Treated with Rituximab Plus CHOP Therapy; A Retrospective Multicenter Japanese Analysis.

Daisuke Ennishi, Yoshinobu Maeda, Nozomi Niitsu, Minoru Kojima, Koji Izutsu, Jun Takizawa, Shigeru Kusumoto, Masataka Okamoto, Masahiro Yokoyama, Yasushi Takamatsu, Kazutaka Sunami, Akira Miyata, Kayoko Murayama, Akira Sakai, Morio Matsumoto, Katsuji Shinagawa, Akinobu Takaki, Keitaro Matsuo, Tomohiro Kinoshita, Mitsune Tanimoto

BLOOD 114 ( 22 ) 1057 - 1057 2009.11

Extranodal NK/T-cell lymphoma.nasal type 20症例の単一施設での治療成績

遠西大輔, 前田嘉信, 近藤正太郎, 原嘉孝, 青山一利, 大西尚子, 久保西四郎, 新谷勝美, 近藤英生, 品川克至, 市村浩一, 吉野正, 谷本光音

臨床血液 50 ( 9 ) 996 - 996 2009.9

同種造血幹細胞移植を施行した進行期、治療抵抗性extranodal NK/T-cell lymphoma,nasal type 10症例の単一施設での治療成績

遠西大輔, 前田嘉信, 品川克至, 久保西四郎, 近藤英生, 新谷勝美, 市村浩一, 吉野正, 谷本光音

日本リンパ網内系学会会誌 49 119 - 119 2009.6

Clinical Outcomes of Unrelated Donor Umbilical Cord Blood Transplantation for 30 Adults with Hematological Malignancies International journal

Koichiro Kobayashi, Yoshinobu Maeda, Yoshitaka Hara, Miyuki Nishie-Kataoka, Hisakazu Nishimori, Haruko Sugiyama, Noriko Namba, Shiro Kubonishi, Masami Niiya, Katsuji Shinagawa, Kazuma Ikeda, Mitsune Tanimoto

ANTICANCER RESEARCH 29 ( 5 ) 1763 - 1770 2009.5

Language：English Publisher：INT INST ANTICANCER RESEARCH

Background: Umbilical cord blood transplantation (CBT) has increasingly been used as a therapeutic option for adult patients for whom allogeneic stem- cell transplantation is not indicated, due to the availability of cord blood. However, myeloablative conditioning regimens are associated with significant mortality, and high relapse rates in reduced-intensity regimens may result in a poor rate of disease-free survival for those with advanced stages of hematological malignancies. Therefore, it remains unknown whether CBT is a truly effective option for such adults with high-risk disease, as well as for those with standard-risk disease. Patients and Methods: Thirty adult patients with a median age of 45 years (range: 16-67) with standard or high-risk disease underwent CBT from unrelated donors at Okayama University Hospital between October 2002 and May 2007. Twenty-one patients had diseases classified as high-risk for transplantation. The median number of nucleated cells in infused cord blood was 2.65x10(7)/kg (range: 1.73-4.87). Results: Twenty-three patients achieved neutrophil engraftment at a median time of 22 days (range: 13-42) after CBT The cumulative incidence of grade II to IV acute graft-versus-host disease (GVHD) was 53.6%. Out of the 30 patients, I I were alive and disease-free at a median time of 446 days (range: 124-1153) after CBT. The cumulative 1-year overall survival in patients with standard-risk or high-risk disease was 63.5% and 15.4%, respectively (p=0.01). Conclusion: Although from a retrospective study, these results suggest that unrelated donor CBT could be safe and effective for adult patients with standard-risk disease who cannot find a suitable HLA-matched volunteer marrow or peripheral blood donor.

Febrile neutropenia and periodontitis: lessons from a case periodontal treatment in the intervals between chemotherapy cycles for leukemia reduced febrile neutropenia International journal

Yoshihiko Soga, Yoshiko Yamasuji, Chieko Kudo, Kaori Matsuura-Yoshimoto, Kokoro Yamabe, Yuko Sugiura, Yoshinobu Maeda, Fumihiko Ishimaru, Mitsune Tanimoto, Fusanori Nishimura, Shogo Takashiba

SUPPORTIVE CARE IN CANCER 17 ( 5 ) 581 - 587 2009.5

Language：English Publisher：SPRINGER

Oral and systemic infections arising from the oral cavity are significant problems in clinical management of patients undergoing leukemia treatment. However, there is significant disparity in the reported incidences of development of periodontal infections. Evidence is limited to those showing the systemic influence of periodontal infection in neutropenic patients. This study indicated an association between febrile neutropenia (FN) and periodontitis in a case in which periodontal treatment in the intervals between chemotherapy cycles reduced FN in subsequent courses of chemotherapy and hematopoietic transplantation (HCT).
Periodontal treatment was performed in a 61-year-old man with advanced periodontitis, who received HCT following three cycles of chemotherapy. After recovery from neutropenia induced by initial chemotherapy, periodontal treatment was performed in each chemotherapy interval period. Following extraction of teeth with severe advanced periodontitis, all teeth were subjected to periodontal pocket curettage and root planning, which are common periodontal treatments to reduce periodontal pockets harboring anaerobic periodontal bacteria, before HCT.
Periodontal treatment successfully reduced periodontal pockets from 4.1 +/- 1.5 mm to 3.0 +/- 0.6 mm, which was almost within the healthy range (< 3.0 mm), before HCT. The frequency of FN decreased significantly with increasing cycles of chemotherapy, and decreases in FN corresponded to progress of periodontal treatment. Blood cultures obtained a total of 12 times throughout leukemia treatment were all negative.
The observations reported here indicate the importance of periodontal treatment in clinical management of patients undergoing leukemia treatment to prevent FN, although all blood cultures were negative.

DOI： 10.1007/s00520-008-0532-z