Updated on 2025/08/01

写真a

 
SATOH Akira
 
Organization
Faculty of Environmental, Life, Natural Science and Technology Professor
Position
Professor
Homepage
http://kaken.nii.ac.jp/d/r/90512004.ja.html
Profile
四肢の発生・再生・ほんの少しだけ進化研究。
External link

Degree

  • 生命科学博士 ( 2006.3   東北大学 )

  • Ph.D. ( 2006.3   Tohoku University )

Research Interests

  • FGF

  • 組織

  • ニワトリ

  • 過剰肢付加モデル

  • 有尾両生類

  • AER

  • 筋肉

  • MMP

  • Axolotl

  • 四肢発生

  • BMP

  • AEC

  • 四肢再生

  • 脱分化

  • 再生

  • 発生

Research Areas

  • Life Science / Developmental biology

Research History

  • Okayama University, Grad. Sch. Env, Life, Nat. Sci. and Tech   Professor

    2023.3

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  • Okayama University   Associate Professor

    2013.4 - 2023.2

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  • Okayama University   Research Core for Interdisciplinary Science

    2011.4 - 2013.3

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  • Okayama University   Research Core for Interdisciplinary Science

    2009.1 - 2011.3

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  • University of California Irvine

    2006.1 - 2008.12

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Papers

  • Co-operative Bmp- and Fgf-signaling inputs convert skin wound healing to limb formation in urodele amphibians Reviewed

    Aki Makanae, Kazumasa Mitogawa, Akira Satoh

    DEVELOPMENTAL BIOLOGY   396 ( 1 )   57 - 66   2014.12

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ydbio.2014.09.021

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  • Keratinocyte-driven dermal collagen formation in the axolotl skin Reviewed

    Ayaka Ohashi, Hirotaka Sakamoto, Junpei Kuroda, Yohei Kondo, Yasuhiro Kamei, Shigenori Nonaka, Saya Furukawa, Sakiya Yamamoto, Akira Satoh

    Nature Communications   16 ( 1 )   2025.2

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    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1038/s41467-025-57055-7

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    Other Link： https://www.nature.com/articles/s41467-025-57055-7

  • Collagen fiber and cellular dynamics of axolotl skin with aging Reviewed

    Shima C., Ohashi A., Furukawa S., Yamamoto S., Kashmoto R., Satoh A., co-first auhotrs

    Development, Growth and Differentiation   in press   2025.2

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  • Allometry in limb regeneration and scale-invariant patterning as the basis of normal morphogenesis from different sizes of blastemas Reviewed

    Furukawa. S, Yamamoto S, Ohashi A, Morishita Y*, Satoh A*, Co-correspondence authors

    Development   151 ( 21 )   2024

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    Authorship：Last author,　Corresponding author   Language：English  

    DOI： 10.1242/dev.202697.

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  • Tenascin-C-enriched regeneration-specific extracellular matrix guarantees superior muscle regeneration in Ambystoma mexicanum Reviewed

    Ayaka Ohashi, Suzuno Terai, Saya Furukawa, Sakiya Yamamoto, Rena Kashimoto, Akira Satoh

    in press   2023.10

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  • FGF signaling induces the regeneration of collagen fiber structure during skin wound healing in axolotls Reviewed

    Rena Kashimoto, Yasuhiro Kamei, Shigenori Nonaka, Yohei Kondo, Sakiya Yamamoto, Saya Furukawa, Ayaka Ohashi, Akira Satoh

    Developmental Biology   498   14 - 25   2023.3

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ydbio.2023.03.007

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  • Bead Implantation and Delivery of Exogenous Growth Factors. International journal

    Rena Kashimoto, Saya Furukawa, Sakiya Yamamoto, Akira Satoh

    Methods in molecular biology (Clifton, N.J.)   2562   209 - 216   2023

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    Language：English   Publishing type：Research paper (scientific journal)  

    Genetic methods in axolotls (Ambystoma mexicanum) remain in their infancy which has hampered the study of limb regeneration. There is much room for advancement, especially with respect to spatiotemporal regulation of gene expression. Secreted growth factors play a major role in each stage of regeneration. The use of slow-release beads is one of the most effective methods to control the spatiotemporal expression of secretory gene products. The topical administration of secreted factors by slow-release beads may also prove effective for future applications in non-regenerative animals and for medical applications in humans, in which genetic methods are not available. In this chapter, we describe a methodology for using and implanting slow-release beads to deliver exogenous growth factors to salamanders.

    DOI： 10.1007/978-1-0716-2659-7_14

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  • Lattice-patterned collagen fibers and their dynamics in axolotl skin regeneration Reviewed

    Rena Kashimoto, Saya Furukawa, Sakiya Yamamoto, Yasuhiro Kamei, Joe Sakamoto, Shigenori Nonaka, Tomonobu M. Watanabe, Tatsuya Sakamoto, Hirotaka Sakamoto, Akira Satoh

    iScience   25 ( 7 )   104524 - 104524   2022.6

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    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.isci.2022.104524

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  • An approach for elucidating dermal fibroblast dedifferentiation in amphibian limb regeneration Invited Reviewed International journal

    Satoh A, Kashimoto R, Ohashi A, Furukawa S, Yamamoto S, Inoue T, Hayashi T, Agata K

    Zoological letters   in press ( 1 )   6 - 6   2022.5

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Urodele amphibians, Pleurodeles waltl and Ambystoma mexicanum, have organ-level regeneration capability, such as limb regeneration. Multipotent cells are induced by an endogenous mechanism in amphibian limb regeneration. It is well known that dermal fibroblasts receive regenerative signals and turn into multipotent cells, called blastema cells. However, the induction mechanism of the blastema cells from matured dermal cells was unknown. We previously found that BMP2, FGF2, and FGF8 (B2FF) could play sufficient roles in blastema induction in urodele amphibians. Here, we show that B2FF treatment can induce dermis-derived cells that can participate in multiple cell lineage in limb regeneration. We first established a newt dermis-derived cell line and confirmed that B2FF treatment on the newt cells provided plasticity in cellular differentiation in limb regeneration. To clarify the factors that can provide the plasticity in differentiation, we performed the interspecies comparative analysis between newt cells and mouse cells and found the Pde4b gene was upregulated by B2FF treatment only in the newt cells. Blocking PDE4B signaling by a chemical PDE4 inhibitor suppressed dermis-to-cartilage transformation and the mosaic knockout animals showed consistent results. Our results are a valuable insight into how dermal fibroblasts acquire multipotency during the early phase of limb regeneration via an endogenous program in amphibian limb regeneration.

    DOI： 10.1186/s40851-022-00190-6

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  • Lmx1b activation in axolotl limb regeneration Reviewed International journal

    Sakiya Yamamoto, Rena Kashimoto, Saya Furukawa, Ayaka Ohashi, Akira Satoh

    Developmental Dynamics   2022.4

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    BACKGROUND: Axolotls can regenerate their limbs. In their limb regeneration process, developmental genes are re-expressed and reorganize the developmental axes, in which the position-specific genes are properly re-expressed. However, how such position specificity is reorganized in the regeneration processes has not been clarified. To address this issue, we focused on the reactivation process of Lmx1b, which determines the limb dorsal identity in many animals. RESULTS: Here, we show that Lmx1b expression is maintained in the dorsal skin before amputation and is activated after amputation. Furthermore, we demonstrate that only cells located in the dorsal side prior to limb amputation could reactivate Lmx1b after limb amputation. We also found that Lmx1b activation was achieved by nerve presence. The nerve factors, BMP2+FGF2+FGF8 (B2FF), consistently reactivate Lmx1b when applied to the dorsal skin. CONCLUSIONS: These results imply that the retained Lmx1b expression in the intact skin plays a role in positional memory, which instruct cells about the spatial positioning before amputation. This memory is reactivated by nerves or nerve factors that can trigger the entire limb regeneration process. Our findings highlight the role of nerves in amphibian limb regeneration, including both the initiation of limb regeneration and the reactivation of position-specific gene expression.

    DOI： 10.1002/dvdy.476

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/dvdy.476

  • Graphene oxide-based multi-component antimicrobial hydrogels Invited Reviewed

    Zahedul Islam Nizami, M.Z.I, Campéon B.D.L, Satoh A, Nishina Y

    Bulletin of the Chemical Society of Japan   in press   2022.4

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  • Variable Shh and Fgf8 positioning in regenerating axolotl limb guarantees consistent limb morphogenesis in different limb sizes

    Saya Furukawa, Sakiya Yamamoto, Rena Kashimoto, Yoshihiro Morishita, Akira Satoh

    2022.1

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    Publisher：Cold Spring Harbor Laboratory  

    Abstract

    Limb regeneration in Ambystoma mexicanum occurs in various size fields and can recreate consistent limb morphology. The mechanism that supports such stable limb morphogenesis regardless of size is unknown. Sonic hedgehog (SHH) and fibroblasts growth factor 8 (FGF8) play important roles in anteroposterior limb patterning, similar to other tetrapods. Focusing on these two factors, we investigated the detailed expression pattern and function of Shh and Fgf8 in various blastema sizes in axolotl limb regeneration. We measured and functionally analyzed the expression domains of Shh and Fgf8 in regenerating limb blastema of various sizes, and found that, although the position and size of the Shh+ and Fgf8+ domains varied depending on the size of the blastema, the secretion of SHH was maintained at a relatively fixed working distance, regardless of blastema size. This stable secretory distance of SHH resulted in the formation of an active proliferative zone (aPZ) in the vicinity of SHH, regardless of blastema size. The aPZ was under the mitogenic influence of SHH and FGF8, resulting in high cell density in the aPZ. We also examined the impact of the aPZ on digit formation. We found that the first digit formation occurs in the aPZ. Next, the aPZ gradually shifts posteriorly as digits develop, which contributes to new digit formation at the site of the shifted aPZ. We also found that the exogenously formed aPZ caused extra digit formation even after the completion of autopod morphogenesis. Our findings suggest that the variable Shh-Fgf8 positioning in various blastema sizes causes various positioning of the aPZ, and that the aPZ leads to digit formation. The mechanism we propose here accounts for stable digit morphogenesis regardless of blastema sizes and urodele-specific digit formation.

    One-Sentence Summary

    A unique SHH-FGF8 spatial interaction compensates for robust limb morphogenesis in various limb sizes.

    DOI： 10.1101/2022.01.04.475010

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  • Nerve-mediated FGF-signaling in the early phase of various organ regeneration. Reviewed International journal

    Sakiya Yamamoto, Rena Kashimoto, Saya Furukawa, Hirotaka Sakamoto, Akira Satoh

    Journal of experimental zoology. Part B, Molecular and developmental evolution   336 ( 7 )   529 - 539   2021.8

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Amphibians have a very high capacity for regeneration among tetrapods. This superior regeneration capability in amphibians can be observed in limbs, the tail, teeth, external gills, the heart, and some internal organs. The mechanisms underlying the superior organ regeneration capability have been studied for a long time. Limb regeneration has been investigated as the representative phenomenon for organ-level regeneration. In limb regeneration, a prominent difference between regenerative and nonregenerative animals after limb amputation is blastema formation. A regeneration blastema requires the presence of nerves in the stump region. Thus, nerve regulation is responsible for blastema induction, and it has received much attention. Nerve regulation in regeneration has been investigated using the limb regeneration model and newly established alternative experimental model called the accessory limb model. Previous studies have identified some candidate genes that act as neural factors in limb regeneration, and these studies also clarified related events in early limb regeneration. Consistent with the nervous regulation and related events in limb regeneration, similar regeneration mechanisms in other organs have been discovered. This review especially focuses on the role of nerve-mediated fibroblast growth factor in the initiation phase of organ regeneration. Comparison of the initiation mechanisms for regeneration in various amphibian organs allows speculation about a fundamental regenerative process.

    DOI： 10.1002/jez.b.23093

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  • Axolotl liver regeneration is accomplished via compensatory congestion mechanisms regulated by ERK signaling after partial hepatectomy. Reviewed International journal

    Ayaka Ohashi, Nanami Saito, Rena Kashimoto, Saya Furukawa, Sakiya Yamamoto, Akira Satoh

    Developmental dynamics : an official publication of the American Association of Anatomists   2020.10

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    BACKGROUND: Axolotls have remarkable organ-level regeneration capability. They can regenerate their limbs, tail, brain, gills, and heart. The liver had been considered to be a regenerative organ in these highly regeneration-competent animals. Therefore, no research had been performed on liver regeneration in urodele amphibians. In the present study, we focused on axolotl liver regeneration and found a unique regeneration mechanism compared with other vertebrates. RESULTS: Partial hepatectomy (PH) was performed to assess axolotl liver regeneration. Regeneration was assessed using block-face imaging (CoMBi), histology, cell proliferation, weight gain, and Albumin (Alb) + area. Axolotl liver histology was compared with other vertebrates. Axolotl liver consists of Glisson's capsule, sinusoids, and hepatic cord with no apparent lobule structures. Hepatocytes were mononucleated or multinucleated. PH increased the multinucleated hepatocytes and the Alb + area, but there was no apparent liver shape recovery even 40 days after PH. Gene expression pattern suggests that no epimorphic regeneration takes place. We also found that the increase in the number of proliferating hepatocytes was regulated by ERK-signaling. CONCLUSION: Our findings suggest that axolotls, which have epimorphic regeneration ability, regenerate their liver via unique mechanisms, compensatory congestion.

    DOI： 10.1002/dvdy.262

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  • Neural regulation in tooth regeneration of Ambystoma mexicanum. Reviewed International journal

    Aki Makanae, Yuki Tajika, Koki Nishimura, Nanami Saito, Jun-Ichi Tanaka, Akira Satoh

    Scientific reports   10 ( 1 )   9323 - 9323   2020.6

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    The presence of nerves is an important factor in successful organ regeneration in amphibians. The Mexican salamander, Ambystoma mexicanum, is able to regenerate limbs, tail, and gills when nerves are present. However, the nerve-dependency of tooth regeneration has not been evaluated. Here, we reevaluated tooth regeneration processes in axolotls using a three-dimensional reconstitution method called CoMBI and found that tooth regeneration is nerve-dependent although the dentary bone is independent of nerve presence. The induction and invagination of the dental lamina were delayed by denervation. Exogenous Fgf2, Fgf8, and Bmp7 expression could induce tooth placodes even in the denervated mandible. Our results suggest that the role of nerves is conserved and that Fgf+Bmp signals play key roles in axolotl organ-level regeneration. The presence of nerves is an important factor in successful organ regeneration in amphibians. The Mexican salamander, Ambystoma mexicanum, is able to regenerate limbs, tail, and gills when nerves are present. However, the nervedependency of tooth regeneration has not been evaluated. Here, we reevaluated tooth regeneration processes in axolotls using a three-dimensional reconstitution method called CoMBI and found that tooth regeneration is nerve-dependent although the dentary bone is independent of nerve presence. The induction and invagination of the dental lamina were delayed by denervation. Exogenous Fgf2, Fgf8, and Bmp7 expression could induce tooth placodes even in the denervated mandible. Our results suggest that the role of nerves is conserved and that Fgf+Bmp signals play key roles in axolotl organ-level regeneration.

    DOI： 10.1038/s41598-020-66142-2

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  • Stability and plasticity of positional memory during limb regeneration in Ambystoma mexicanum. Reviewed

    Iwata R, Makanae A, Satoh A

    Developmental dynamics : an official publication of the American Association of Anatomists   2019.8

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    DOI： 10.1002/dvdy.96

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  • Fgf- and Bmp-signaling regulate gill regeneration in Ambystoma mexicanum. Reviewed

    Saito N, Nishimura K, Makanae A, Satoh A

    Developmental biology   452 ( 2 )   104 - 113   2019.8

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    Authorship：Last author,　Corresponding author  

    DOI： 10.1016/j.ydbio.2019.04.011

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  • Ectopic Fgf signaling induces the intercalary response in developing chicken limb buds Reviewed

    Aki Makanae, Akira Satoh

    Zoological Letters   4 ( 1 )   8   2018.4

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：BioMed Central Ltd.  

    DOI： 10.1186/s40851-018-0090-2

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  • Hyperinnervation improves Xenopus laevis limb regeneration Reviewed

    Kazumasa Mitogawa, Aki Makanae, Akira Satoh

    Developmental Biology   433 ( 2 )   276 - 286   2018.1

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier Inc.  

    DOI： 10.1016/j.ydbio.2017.10.007

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  • Nerve roles in blastema induction and pattern formation in limb regeneration. Reviewed

    Satoh A, Mitogawa K, Makanae A

    The International journal of developmental biology   62 ( 9-10 )   605 - 612   2018

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    DOI： 10.1387/ijdb.180118as

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  • Reactivation of larval keratin gene (krt62.L) in blastema epithelium during Xenopus froglet limb regeneration Reviewed

    Akira Satoh, Kazumasa Mitogawa, Nanami Saito, Miyuki Suzuki, Ken-ichi T. Suzuki, Haruki Ochi, Aki Makanae

    DEVELOPMENTAL BIOLOGY   432 ( 2 )   265 - 272   2017.12

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ydbio.2017.10.015

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  • FGF and BMP derived from dorsal root ganglia regulate blastema induction in limb regeneration in Ambystoma mexicanum Reviewed

    Akira Satoh, Aki Makanae, Yurie Nishimoto, Kazumasa Mitogawa

    DEVELOPMENTAL BIOLOGY   417 ( 1 )   114 - 125   2016.9

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ydbio.2016.07.005

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  • Cooperative inputs of Bmp and Fgf signaling induce tail regeneration in urodele amphibians Reviewed

    Aki Makanae, Kazumasa Mitogawa, Akira Satoh

    DEVELOPMENTAL BIOLOGY   410 ( 1 )   45 - 55   2016.2

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ydbio.2015.12.012

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  • Skeletal callus formation is a nerve-independent regenerative response to limb amputation in mice and Xenopus. Reviewed

    Miura S, Takahashi Y, Satoh A, Endo T

    Regeneration (Oxford, England)   2 ( 4 )   202 - 216   2015.8

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  • Regeneration inducers in limb regeneration Reviewed

    Akira Satoh, Kazumasa Mitogawa, Aki Makanae

    DEVELOPMENT GROWTH & DIFFERENTIATION   57 ( 6 )   421 - 429   2015.8

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    Authorship：Lead author,　Corresponding author   Language：English  

    DOI： 10.1111/dgd.12230

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  • Comparative Analysis of Cartilage Marker Gene Expression Patterns during Axolotl and Xenopus Limb Regeneration Reviewed

    Kazumasa Mitogawa, Aki Makanae, Ayano Satoh, Akira Satoh

    PLOS ONE   10 ( 7 )   e0133375   2015.7

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0133375

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  • Skeletal Callus Formation is a Nerve-independent Regenerative Response to Limb Amputation in Mice and Xenopus Reviewed

    Miura S, Takahashi Y, Satoh A, Endo T

    Regeneration   2 ( 4 )   202 - 216   2015.1

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  • The accessory limb model: an alternative experimental system of limb regeneration. Reviewed

    Endo T, Gardiner DM, Makanae A, Satoh A

    Methods in molecular biology (Clifton, N.J.)   1290   101 - 113   2015

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    DOI： 10.1007/978-1-4939-2495-0_8

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  • Identification of a feather beta-keratin gene exclusively expressed in pennaceous barbule cells of contour feathers in chicken Reviewed

    Kinue Kowata, Minori Nakaoka, Kaori Nishio, Ayaka Fukao, Akira Satoh, Maho Ogoshi, Sumio Takahashi, Masaoki Tsudzuki, Sakae Takeuchi

    GENE   542 ( 1 )   23 - 28   2014.5

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    DOI： 10.1016/j.gene.2014.03.027

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  • Ectopic blastema induction by nerve deviation and skin wounding: A new regeneration model in Xenopus laevis Reviewed

    Mitogawa K, Hirata A, Moriyasu M, Makanae A, Miura S, Endo T, Satoh A

    Regeneration   1 ( 2 )   26 - 36   2014.1

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  • Implication of two different regeneration systems in limb regeneration Reviewed

    Makanae A, Mitogawa K, Satoh A

    Regeneration   1 ( 3 )   1 - 9   2014.1

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  • Conservation of Position-specific Gene Expression in Axolotl Limb Skin Reviewed

    Akira Satoh, Aki Makanae

    ZOOLOGICAL SCIENCE   31 ( 1 )   6 - 13   2014.1

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2108/zsj.31.6

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  • Nerve independent limb induction in axolotls Reviewed

    Aki Makanae, Ayako Hirata, Yasuko Honjo, Kazumasa Mitogawa, Akira Satoh

    Developmental Biology   381 ( 1 )   213 - 226   2013.9

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Academic Press Inc.  

    DOI： 10.1016/j.ydbio.2013.05.010

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  • Accessory limb induction on flank region and its muscle regulation in axolotl Reviewed

    Ayako Hirata, Aki Makanae, Akira Satoh

    Developmental Dynamics   242 ( 8 )   932 - 940   2013.8

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/dvdy.23984

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  • Spatiotemporal regulation of keratin 5 and 17 in the axolotl limb Reviewed

    Miyuki Moriyasu, Aki Makanae, Akira Satoh

    DEVELOPMENTAL DYNAMICS   241 ( 10 )   1616 - 1624   2012.10

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    DOI： 10.1002/dvdy.23839

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  • Early Regulation of Axolotl Limb Regeneration Reviewed

    Aki Makanae, Akira Satoh

    ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY   295 ( 10 )   1566 - 1574   2012.10

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    DOI： 10.1002/ar.22529

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  • Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl Reviewed

    Wei Zhu, Gerald M. Pao, Akira Satoh, Gillian Cummings, James R. Monaghan, Timothy T. Harkins, Susan V. Bryant, S. Randal Voss, David M. Gardiner, Tony Hunter

    DEVELOPMENTAL BIOLOGY   370 ( 1 )   42 - 51   2012.10

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    DOI： 10.1016/j.ydbio.2012.07.021

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  • Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration Reviewed

    Wei Zhu, Dwight Kuo, Jason Nathanson, Akira Satoh, Gerald M. Pao, Gene W. Yeo, Susan V. Bryant, S. Randal Voss, David M. Gardiner, Tony Hunter

    DEVELOPMENT GROWTH & DIFFERENTIATION   54 ( 7 )   673 - 685   2012.9

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    DOI： 10.1111/j.1440-169X.2012.01368.x

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  • Nerve signaling regulates basal keratinocyte proliferation in the blastema apical epithelial cap in the axolotl (Ambystoma mexicanum) Reviewed

    Akira Satoh, Susan V. Bryant, David M. Gardiner

    DEVELOPMENTAL BIOLOGY   366 ( 2 )   374 - 381   2012.6

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    DOI： 10.1016/j.ydbio.2012.03.022

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  • Collagen Reconstitution Is Inversely Correlated with Induction of Limb Regeneration in Ambystoma mexicanum Reviewed

    Akira Satoh, Ayako Hirata, Aki Makanae

    ZOOLOGICAL SCIENCE   29 ( 3 )   191 - 197   2012.3

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    DOI： 10.2108/zsj.29.191

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  • Blastema induction in aneurogenic state and Prrx-1 regulation by MMPs and FGFs in Ambystoma mexicanum limb regeneration Reviewed

    Akira Satoh, Aki Makanae, Ayako Hirata, Yutaka Satou

    DEVELOPMENTAL BIOLOGY   355 ( 2 )   263 - 274   2011.7

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    DOI： 10.1016/j.ydbio.2011.04.017

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  • Regulation of proximal-distal intercalation during limb regeneration in the axolotl (Ambystoma mexicanum) Reviewed

    Akira Satoh, Gillian M. C. Cummings, Susan V. Bryant, David M. Gardiner

    DEVELOPMENT GROWTH & DIFFERENTIATION   52 ( 9 )   785 - 798   2010.12

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    DOI： 10.1111/j.1440-169X.2010.01214.x

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  • Ex vivo generation of a functional and regenerative wound epithelium from axolotl (Ambystoma mexicanum) skin Reviewed

    Donald R. Ferris, Akira Satoh, Berhan Mandefro, Gillian M. Cummings, David M. Gardiner, Elizabeth L. Rugg

    DEVELOPMENT GROWTH & DIFFERENTIATION   52 ( 8 )   715 - 724   2010.10

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    DOI： 10.1111/j.1440-169X.2010.01208.x

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  • The apical ectodermal ridge (AER) can be re-induced by wounding, wnt-2b, and fgf-10 in the chicken limb bud Reviewed

    Akira Satoh, Aki Makanae, Naoyuki Wada

    DEVELOPMENTAL BIOLOGY   342 ( 2 )   157 - 168   2010.6

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    DOI： 10.1016/j.ydbio.2010.03.018

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  • Dermal fibroblasts contribute to multiple tissues in the accessory limb model Reviewed

    Ayako Hirata, David M. Gardiner, Akira Satoh

    DEVELOPMENT GROWTH & DIFFERENTIATION   52 ( 4 )   343 - 350   2010.5

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1440-169X.2009.01165.x

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  • Analysis of hoxa11 and hoxa13 expression during patternless limb regeneration in Xenopus Reviewed

    Shiro Ohgo, Akari Itoh, Makoto Suzuki, Akira Satoh, Hitoshi Yokoyama, Koji Tamura

    DEVELOPMENTAL BIOLOGY   338 ( 2 )   148 - 157   2010.2

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    DOI： 10.1016/j.ydbio.2009.11.026

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  • Neurotrophic regulation of fibroblast dedifferentiation during limb skeletal regeneration in the axolotl (Ambystoma mexicanum) Reviewed

    Akira Satoh, Gillian M. C. Cummings, Susan V. Bryant, David M. Gardiner

    DEVELOPMENTAL BIOLOGY   337 ( 2 )   444 - 457   2010.1

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    DOI： 10.1016/j.ydbio.2009.11.023

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  • Effects of Activation of Hedgehog Signaling on Patterning, Growth, and Differentiation in Xenopus Froglet Limb Regeneration Reviewed

    Nayuta Yakushiji, Makoto Suzuki, Akira Satoh, Hiroyuki Ide, Koji Tamura

    DEVELOPMENTAL DYNAMICS   238 ( 8 )   1887 - 1896   2009.8

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    DOI： 10.1002/dvdy.22011

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  • The Role of Nerve Signaling in Limb Genesis and Agenesis During Axolotl Limb Regeneration Reviewed

    Akira Satoh, Michelle A. James, David M. Gardiner

    JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME   91A   90 - 98   2009.7

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    DOI： 10.2106/JBJS.I.00159

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  • Regulation of dermal fibroblast dedifferentiation and redifferentiation during wound healing and limb regeneration in the Axolotl Reviewed

    Akira Satoh, Susan V. Bryant, David M. Gardiner

    DEVELOPMENT GROWTH & DIFFERENTIATION   50 ( 9 )   743 - 754   2008.12

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1440-169X.2008.01072.x

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  • Neurotrophic regulation of epidermal dedifferentiation during wound healing and limb regeneration in the axolotl (Ambystoma mexicanum) Reviewed

    A. Satoh, G. M. C. Graham, S. V. Bryant, D. M. Gardiner

    DEVELOPMENTAL BIOLOGY   319 ( 2 )   321 - 335   2008.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ydbio.2008.04.030

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  • Mitf contributes to melanosome distribution and melanophore dendricity Reviewed

    Akiha Kawasaki, Mayuko Kumasaka, Akira Satoh, Makoto Suzuki, Koji Tamura, Toshiyasu Goto, Makoto Asashima, Hiroaki Yamamoto

    PIGMENT CELL & MELANOMA RESEARCH   21 ( 1 )   56 - 62   2008.2

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    DOI： 10.1111/j.1755-148X.2007.00420.x

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  • Nerve-induced ectopic limb blastemas in the axolotl are equivalent to amputation-induced blastemas Reviewed

    Akira Satoh, David M. Gardiner, Susan V. Bryant, Tetsuya Endo

    DEVELOPMENTAL BIOLOGY   312 ( 1 )   231 - 244   2007.12

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ydbio.2007.09.021

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  • Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibians Reviewed

    Nayuta Yakushiji, Makoto Suzuki, Akira Satoh, Tomoko Sagai, Toshihiko Shiroishi, Hisato Kobayashi, Hiroyuki Sasaki, Hiroyuki Ide, Koji Tamura

    DEVELOPMENTAL BIOLOGY   312 ( 1 )   171 - 182   2007.12

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    DOI： 10.1016/j.ydbio.2007.09.022

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  • Transgenic Xenopus with prx1 limb enhancer reveals crucial contribution of MEK/ERK and PI3K/AKT pathways in blastema formation during limb regeneration Reviewed

    Makoto Suzuki, Akira Satoh, Hiroyuki Ide, Koji Tamura

    DEVELOPMENTAL BIOLOGY   304 ( 2 )   675 - 686   2007.4

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    DOI： 10.1016/j.ydbio.2007.01.019

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  • Limb regeneration in Xenopus laevis froglet Reviewed

    Makoto Suzuki, Nayuta Yakushiji, Yasuaki Nakada, Akira Satoh, Hiroyuki Ide, Koji Tamura

    THESCIENTIFICWORLDJOURNAL   6   26 - 37   2006.12

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    DOI： 10.1100/tsw.2006.325

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  • Characterization of Xenopus digits and regenerated limbs of the froglet Reviewed

    Akira Satoh, Tetsuya Endo, Masahiro Abe, Nayuta Yakushiji, Shiro Ohgo, Koji Tamura, Hiroyuki Ide

    DEVELOPMENTAL DYNAMICS   235 ( 12 )   3316 - 3326   2006.12

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/dvdy.20985

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  • Limb regeneration in Xenopus laevis froglet. Reviewed

    Suzuki M, Yakushiji N, Nakada Y, Satoh A, Ide H, Tamura K

    TheScientificWorldJournal   6 Suppl 1   26 - 37   2006.5

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  • Analysis of scleraxis and dermo-1 genes in a regenerating limb of Xenopus laevis Reviewed

    A Satoh, Y Nakada, M Suzuki, K Tamura, H Ide

    DEVELOPMENTAL DYNAMICS   235 ( 4 )   1065 - 1073   2006.4

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    DOI： 10.1002/dvdy.20701

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  • Characteristics of initiation and early events for muscle development in the Xenopus limb bud Reviewed

    A Satoh, K Sakamaki, H Ide, K Tamura

    DEVELOPMENTAL DYNAMICS   234 ( 4 )   846 - 857   2005.12

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    DOI： 10.1002/dvdy.20573

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  • Nerve-dependent and -independent events in blastema formation during Xenopus froglet limb regeneration Reviewed

    M Suzuki, A Satoh, H Ide, K Tamura

    DEVELOPMENTAL BIOLOGY   286 ( 1 )   361 - 375   2005.10

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    DOI： 10.1016/j.ybio.2005.08.021

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  • Joint development in Xenopus laevis and induction of segmentations in regenerating froglet limb (spike) Reviewed

    A Satoh, M Suzuki, T Amano, K Tamura, H Ide

    DEVELOPMENTAL DYNAMICS   233 ( 4 )   1444 - 1453   2005.8

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    DOI： 10.1002/dvdy.20484

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  • Muscle formation in regenerating Xenopus froglet limb Reviewed

    A Satoh, H Ide, K Tamura

    DEVELOPMENTAL DYNAMICS   233 ( 2 )   337 - 346   2005.6

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    DOI： 10.1002/dvdy.20349

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Books

  • 岩波「科学」 科学通信

    大蘆彩夏, 佐藤 伸（ Role： Joint author ,  永遠のたまご肌！？ ウーパールーパーの皮膚の秘密を解き明かす）

    岩波  2025.8 

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  • Chapter "Bead implantation and delivery of exogenous growth factors" in Methods in Salamander Research

    2023  （ ISBN:9781071626597 ）

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  • ウーパールーパー 蛇足つけます 驚異のわがままボディ

    佐藤伸, 樫本玲菜

    医学の歩み Vol 278 No 12  2021.9 

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  • ウーパールーパーを使った器官再生研究

    蒔苗亜紀, 佐藤

    実験医学 Vol.30 No.8  2018.5 

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MISC

  • Mitf contributes to melanosome distribution and melanophore dendricity

    Akiha Kawasaki, Mayuko Kumasaka, Akira Satoh, Makoto Suzuki, Koji Tamura, Toshiyasu Goto, Makoto Asashima, Hiroaki Yamamoto

    PIGMENT CELL & MELANOMA RESEARCH   21 ( 2 )   269 - 270   2008.4

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  • マウス四肢の再生能

    井出宏之, 正木英樹, 佐藤伸, 薬師寺那由他

    日本動物学会大会要旨集   78th   35   2007.8

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    Language：Japanese  

    J-GLOBAL

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  • A role of Mitf in melanophore dendricity - In vitro analysis-

    Akiha Kawasaki, Akira Satoh, Kazuaki Takahashi, Mayuko Kumasaka, Toshiyasu Goto, Makoto Asashima, Hiroaki Yamamoto

    ZOOLOGICAL SCIENCE   23 ( 12 )   1177 - 1177   2006.12

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  • Relationship between spike formation and proximodistal patterning during Xenopus froglet limb regeneration

    Shiro Ohgo, Akari Itoh, Makoto Suzuki, Akira Satoh, Hiroyuki Ide, Koji Tamura

    ZOOLOGICAL SCIENCE   23 ( 12 )   1180 - 1180   2006.12

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  • Imcomplete anterior-posterior axis formation in Xenopus froglet limb regeneration

    Nayuta Yakushiji, Akira Satoh, Makoto Suzuki, Hiroyuki Ide, Koji Tamura

    ZOOLOGICAL SCIENCE   22 ( 12 )   1470 - 1470   2005.12

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  • Blastema formation and outgrowth during Xenopus froglet limb regeneration

    M. Suzuki, A. Satoh, H. Ide, K. Tamura

    MECHANISMS OF DEVELOPMENT   122   S129 - S129   2005.9

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  • Restoration of joints in Xenopus froglet limb regeneration

    A. Satoh, M. Suzuki, T. Amano, K. Tamura, H. Ide

    MECHANISMS OF DEVELOPMENT   122   S129 - S129   2005.9

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Presentations

  • A new method for recording morphological changes in axolotl limb regeneration Invited

    Akira Satoh, Reiko Iwata, Saya Furukawa

    2024.8.1 

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    Event date： 2024.7.31 - 2024.8.2

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

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  • Flexible Shh and Fgf8 expression domains in regenerating axolotl limb guarantee consistent limb morphogenesis in different limb sizes. Invited

    AKIRA SATOH

    2022 Salamander meeting (Turkey)  2022.8.23 

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    Event date： 2022.8.21 - 2022.8.24

    Presentation type：Oral presentation (invited, special)  

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  • Analysis of collagen structure in axolotl skin regeneration

    rena kashimoto, akira satoh

    2021.12.1 

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    Event date： 2021.12.1 - 2021.12.3

    Presentation type：Poster presentation  

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  • Keratinosyte-driven collagen formation in Ambystoma mexicanum Invited

    International Symposium on Morphogenesis by Non-Cellular Materials  2024.11.25 

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  • アホロートル四肢再生の開始機構とアホロートルを利用した皮膚研究の展開 Invited

    佐藤伸

    山梨大学 生命科学の最前線（全8回）  2024.11.15 

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  • Induction Mechanism Of Axolotl Limb Regeneration Invited

    7th TERMIS World Congress 2024 - Seattle, Washington.  2024.6.27 

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  • Allometry in limb regeneration and scale-invariant patterning as a basis of normal morphogenesis from different sizes of blastemas

    2024.6.19 

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  • メキシコサラマンダー四肢再生における 分化リプロミングを理解するための基盤研究 Invited

    佐藤 伸

    日本再生医療学会  2024.3.22 

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    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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  • The Trigger Signal For Amphibian Limb Regeneration: BMP and FGF in Inducing Blastema Formation Invited

    2024.3.6 

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  • アホロートルの優れた筋再生能力と細胞外マトリックスの役割

    大蘆彩夏, 佐藤伸

    第46回日本分子生物学会年会  2023.12.8 

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    Presentation type：Poster presentation  

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  • アホロートル真皮内において細胞が編み出すコラーゲンの構造 Invited

    Akira Satoh, Ayaka Ohashi

    第46回日本分子生物学会年会 シンポジウム「組織構築を創出するコラーゲンの「新・動態」に迫る」  2023.12.8 

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    Presentation type：Symposium, workshop panel (nominated)  

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  • アホロートル四肢再生における多様な大きさの再生芽でのShh・Fgf8の発現領域サイズと細胞分布動態の比較解析

    古川彩絢, 森下喜弘, 佐藤伸

    第46回日本分子生物学会年会  2023.12.7 

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  • アホロートルの表皮細胞が作る真皮コラーゲン構造構築法の解明

    大蘆彩夏, 黒田純平, 佐藤伸

    第46回日本分子生物学会年会  2023.12.7 

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  • アホロートル（Ambystoma mexicanum）の歯再生は神経依存的であり、FGFシグナルによって代替される Invited

    佐藤伸

    第77回NPO法人日本口腔科学会学術集会  2023.5.12 

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    Presentation type：Symposium, workshop panel (nominated)  

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  • 両生類を用いた再生研究の進展 Invited

    佐藤 伸

    第79回 岡山実験動物研究会  2022.12.9 

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  • 両生類界で最も著名な人類になりました。 Invited

    佐藤伸

    Scienc-ome  2022.10.13 

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  • Lattice-patterned collagen fibers in the dermis and their dynamics in regeneration of axolotls

    2022 Salamander meeting (Turkey)  2022.8.23 

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  • Lattice-patterned collagen fibers in the dermis and their dynamics in regeneration of axolotls

    AKIRA SATOH

    ISRB REGENERATION AROUND THE WORLD MEETING  2022.4.20 

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    Language：English   Presentation type：Symposium, workshop panel (nominated)  

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  • Dermal collagen structure of the axolotl skin Invited

    AKIRA SATOH

    Japan - Australia - Singapore Skin Webinar Series  2022.2.8 

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    Language：English   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    File： SRSS-JSID 2022 8 Feb22.pdf

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  • アホロートル四肢再生における新日繊維芽細胞の「分化の揺らぎ」に関与する遺伝子

    佐藤伸

    日本動物学会 2021 オンライン  2021.9.2 

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  • 再生芽細胞の多能性付与機構に迫る Invited

    佐藤伸

    第3回再生学異分野融合研究会  2021.8.24 

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    Presentation type：Symposium, workshop panel (nominated)  

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  • Signal to become a blastema cell Invited

    2021 Salamander meeting  2021.8.16 

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  • Liver regeneration in ambstoma mexicanum

    the 53rd JSDB/APDBN meeting (on-line meeting)  2020.9.24 

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  • メキシコサラマンダーにおける肝再生

    大蘆彩加, 齋藤奈波, 佐藤伸

    日本動物学会（オンライン） 第91回  2020.9.5 

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  • 両生類四肢再生における皮膚の リプログラミング機構へのアプローチ Invited

    佐藤伸

    日本動物学会（オンライン） 第91回  2020.9.4 

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    Presentation type：Symposium, workshop panel (nominated)  

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  • 四肢再生とパターン形成 Invited

    佐藤 伸

    再生異分野融合研究会  2019.8.27 

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  • 発生システムをベースにした 再生と細胞の時空間認知

    佐藤 伸

    日本動物学会 第90回 大阪大会  2019.8.13 

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    Presentation type：Symposium, workshop panel (nominated)  

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  • A transcriptome analysis for identifying downstream molecules of nerve factors, and Tva system in urodele amphibians. Invited

    SATOH AKIRA

    the 52rd JSDB/APDBN meeting  2019.5.16 

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  • 両生類型の再生システムは哺乳りでも共通なのか？

    AKIRA SATOH

    再生異分野融合研究会  2018 

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    Venue：岡崎カンファレンスホール  

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  • 生物の持つタイムマシン機構!? 再生方法を両生類に聞いてみました

    AKIRA SATOH

    AMEDシンポジウム  2018 

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    Venue：品川  

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  • メキシコサラマンダーの四肢再生と骨再生

    AKIRA SATOH

    骨代謝学会  2018 

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    Venue：長崎新聞文化ホール  

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  • Induction of intercalary responses in chicken limb bud

    AKIRA SATOH

    APDBN/JSDB/JSCB Meeting  2018 

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    Venue：船堀タワーホール  

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  • Induction of regeneration callus (blastema) in ANIMALS

    AKIRA SATOH

    植物生理学会  2018 

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    Venue：札幌コンベンションセンター  

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  • Regeneration principal of appendage regeneration

    AKIRA SATOH

    CDBセミナー  2018 

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    Venue：CDB  

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  • 器官レベルの再生を実現するために

    AKIRA SATOH

    生化学若手の会  2017 

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    Venue：岡山大学  

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  • Nerve functions in blastema induction and pattern formation in limb regeneration

    AKIRA SATOH

    14th Limb Meeting  2017 

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    Venue：Edinburph  

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  • epidermal reporogramming during limb regeneration of xenopus froglet

    AKIRA SATOH

    JSDB (APDBN)  2017 

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    Venue：東京（船堀タワーホール）  

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  • FGFシグナル活性化によるニワトリ胚肢芽の挿入再生反応

    AKIRA SATOH

    日本動物学会  2017 

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    Venue：富山大会  

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  • 発生システムの再起動による器官レベルの再生

    AKIRA SATOH

    AMED交流会  2017 

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    Venue：イイノホール  

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  • 両生類の再生システムを暖かい動物に応用する

    AKIRA SATOH

    ユニークな少数派実験動物を扱う若手が最先端アプローチを勉強する会  2017 

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    Venue：基礎生物学研究所  

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  • Hyperinnervation stimulate improvement of Xenopus laevis limb regeneration

    AKIRA SATOH

    JSDB (APDBN)  2017 

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    Venue：東京（船堀タワーホール）  

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  • 器官再生誘導物質の応用例と展望

    AKIRA SATOH

    １６回日本再生医療学会  2017 

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    Venue：仙台国際施センター  

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  • メキシコサラマンダ―における器官再生研究

    AKIRA SATOH

    ユニークな少数派実験動物を扱う若手が最先端アプローチを勉強する会  2016 

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    Venue：岡崎コンフェレンスセンター  

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  • メキシコサラマンダーDRGにおけるFGF8 ＆BMP7遺伝子KDによる四肢再生阻害

    AKIRA SATOH

    3学会  2016 

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    Venue：鳥取コンベンションセンター  

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  • organ regeneration; pioneering another choice

    AKIRA SATOH

    ?International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research  2016 

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    Venue：Okazaki Japan NIBB  

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  • Regeneration inducers of appendage regeneration

    AKIRA SATOH

    International Congress of Zoology  2016 

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    Venue：OIST  

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  • 器官再生誘導物質の同定と 高等脊椎動物への応用に向けた展望

    AKIRA SATOH

    第14回再生医療学会  2015 

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    Venue：パシフィコ横浜  

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  • Defined molecules induce organ regeneration in urodele amphibians

    AKIRA SATOH

    動物学会北海道支部  2015 

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    Venue：北海道大学  

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  • アフリカツメガエルの四肢再生能力を向上させる神経の役割

    AKIRA SATOH

    分子生物学会  2015 

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    Venue：神戸  

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  • 有尾両生類四肢再生反応の誘導因子の同定

    AKIRA SATOH

    日本動物学会  2015 

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    Venue：新潟 朱鷺メッセ  

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  • Regenerative medicine for organ regeneration in urodele amphibians

    AKIRA SATOH

    Limb Meeting  2015 

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    Venue：Florida, Tampa  

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  • 多分化能を有する細胞を誘導するシグナルインプット 〜メキシコサラマンダーの器官再生誘導因子〜

    AKIRA SATOH

    分子生物学会  2015 

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    Venue：神戸  

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  • Fundamental mechanisms for multiple organ regeneration in urodele amphibians

    AKIRA SATOH

    発生生物学会  2015 

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    Venue：筑波国際会議場  

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  • Defined molecules induce organ regeneration in urodele amphibians

    AKIRA SATOH

    熊本大学セミナー  2014 

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    Venue：熊本大学  

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  • BMP/FGFシグナルの協調的活性化により傷修復反応が四肢再生反応に転換される

    AKIRA SATOH

    日本動物学会  2014 

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    Venue：仙台  

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  • Cooperative BMP- and FGF-Signaling Inputs Transform Skin Wound Healing to Limb Formation in Urodele Amphibians

    AKIRA SATOH

    EMBO Conference  2014 

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    Venue：スペイン  

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  • 皮膚損傷修復反応から四肢形成反応に転換する「再生物質」

    AKIRA SATOH

    高遠シンポジウム  2014 

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    Venue：長野県 高遠 さくらホテル  

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  • 「アートな形の再生」

    AKIRA SATOH

    札幌芸術祭  2014 

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    Venue：札幌駅地下B１F  

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  • Comparative analysis of cartilage marker gene expression pattern in axolotl and Xenopus limb regeneration

    AKIRA SATOH

    動物学会支部会  2014 

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    Venue：岡山理科大学  

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  • 器官再生への基盤メカニズム 〜有尾両生類の四肢再生〜

    AKIRA SATOH

    日本バイオマテリアル学会  2014 

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    Venue：岡山大学 J.Fホール  

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  • （研究指導）

    AKIRA SATOH

    （立命館高校）  2014 

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  • 四肢再生の開始機構

    AKIRA SATOH

    CREST-PRESTO合同シンポジウム 「iPS細胞研究の今」  2014 

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    Venue：未来科学博物館  

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  • 皮膚修復反応を四肢再生反応に相転移させる「再生薬」の発見とその応用

    AKIRA SATOH

    発生学会 秋季シンポジウム  2013 

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    Venue：神戸しあわせの村  

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  • 両生類四肢再生開始メカニズムの確定とその展開

    AKIRA SATOH

    岡山歯学会  2013 

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    Venue：岡山大学 歯学部  

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  • 大規模損傷に対応する有尾両生類の再生メカニズム（FGFシグナリングに注目した分化リプログラミング）

    AKIRA SATOH

    日本再生医療学会  2013 

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    Venue：パシフィコ横浜  

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  • アフリカツメガエルにおける新規再生研究系

    AKIRA SATOH

    日本動物学会  2013 

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    Venue：岡山  

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  • 両生類の四肢再生メカニズム の解明とその可能性

    AKIRA SATOH

    ブレインストーミングin牛窓  2013 

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    Venue：岡山・牛窓  

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  • A proposal of Regenerative Medicines From Axolotl study

    AKIRA SATOH

    IDEM  2013 

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    Venue：東京大学  

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  • Finding molecular triggers of limb regeneration in axolotls

    AKIRA SATOH

    JSDB (APDBN)  2013 

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    Venue：松江（くにびきメッセ）  

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  • ErbB2/ErbB3 signaling in DRG neuron formation

    AKIRA SATOH

    Cold spring harbor asia "Fishing for Answer:Zebrafish Models of Human Development & Disease" meeting  2012 

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    Venue：Suzhou Dushu Lake Conference Center (中国蘇州）  

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  • Early regulation in axolotl limb regeneration

    AKIRA SATOH

    Asia Pacific Developmental Biology Conference  2012 

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    Venue：Taipei  

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  • Position specific gene expression pattern is maintained in an axolotl limb. ~feasible explanation about positional memory~

    AKIRA SATOH

    日本発生生物学会  2012 

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    Venue：神戸  

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  • Comparative analysis of cartilage marker gene expression patterns in axolotl and Xenopus limb regeneration

    AKIRA SATOH

    日本発生生物学会 年会 

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    Venue：ウインク愛知  

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Awards

  • Interstellar initiative Top team presentation award

    2017.3   New York Academy of science  

    Akira Satou

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  • 先進教育賞

    2016.8   岡山大学  

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  • アクティブラーニング賞

    2016.8   岡山大学  

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  • n.a.

    2015.9   The Zoological Society of Japan  

    Akira Satou

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  • n.a.

    2015.6   MEXT  

    Akira Satou

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  • The presidental Award

    2006.3   Tohoku University  

    Akira Satou

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Research Projects

  • ウーパールーパーの四肢再生における分化リプログラミング因子の機能解析

    2021.04 - 2022.03

    山陽放送学術文化･スポーツ振興財団 

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    Grant amount：\300000 （ Direct expense: \300000 ）

  • 瘢痕を残さない皮膚再生メカニズム

    2021.04 - 2022.03

    小柳財団 

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    Authorship：Principal investigator 

    Grant amount：\1000000 （ Direct expense: \1000000 ）

  • 四肢再生における分化リプログラミング＆発生プログラム再起動を司る遺伝子機能

    Grant number：20H03264  2020.04 - 2024.03

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    佐藤 伸

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    Grant amount：\17680000 （ Direct expense: \13600000 、 Indirect expense：\4080000 ）

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  • Induction of Intercalary regeneration in chicken limb buds

    Grant number：17K19400  2017.06 - 2019.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Challenging Research (Exploratory)  Challenging Research (Exploratory)

    SATOH AKIRA

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    Grant amount：\6500000 （ Direct expense: \5000000 、 Indirect expense：\1500000 ）

    Our previous studies clearly shown that Fgf2+Fgf8+Bmp7 are the regeneration inducers in urodele amphibians. The identified regeneration inducers can induce regeneration responses in varied organs and multiple species. In the present study, we tried to apply our defined molecules onto chicken limb buds in order to withdraw potential regeneration ability. Amphibian limb regeneration takes so called a intercalation mechanism. Chicken limb buds do not have the intercalary regeneration mechanism. However, we demonstrated that the ectopic Fgf2+Fgf8 expression in a chicken limb bud resulted in induction of interacalary responses. We also performed cell lineage analysis using a chick-quail chimera analysis. Our results indicate that the conserved regeneration mechanism can induced by Fgf2+Fgf8 inputs even in non-regenerative animals.

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  • 四肢再生全般を支配する神経因子の解明と再生不能(不全)動物への応用

    Grant number：17H03685  2017.04 - 2021.03

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    佐藤 伸

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    Grant amount：\17160000 （ Direct expense: \13200000 、 Indirect expense：\3960000 ）

    両生類の四肢再生では神経が不可欠な役割を果たすことが明らかであったが、確実な分子実体が明かされることはなかった。四肢再生において神経は「再生の開始」と「パターンの再形成」を制御している。我々は、当該分野の長年の悲願であった「再生の開始」を支配する神経因子（FGF+BMP）の同定に成功した。しかし尚、「パターンの再形成」を制御する神経因子はいまだ謎である。本研究内では、これまでに明らかにした成果を基に、パターンの再形成を支配する神経因子の同定を試みる。さらに、同定する因子を操作することで、再生不全動物（アフリカツメガエル）および再生不能動物（ニワトリ胚）において四肢再生の誘導と完遂に挑むことを目的にしている。本実験期間では後根神経節における神経因子の阻害実験とアフリカツメガエルにおける再生誘導実験を行った。後根神経節における遺伝子機能阻害は長鎖の二本鎖RNAの導入によって行った。この方法はプラナリアで確立された方法であり、兵庫県立大学の協力によって手法を確立した。後根神経節による当該遺伝子の阻害は再生能力を損なわせるものであることから、同定済み遺伝子が神経因子である事の確実な証拠として考えられる。アフリカツメガエルの実験においては神経因子として確立した遺伝子のエレクトロポレーションによる導入を行った。期待したほどに効果は出なかったが幾分かの再生構造の改善は観察された。両者ともに本報告書を書くまでに論文として報告しており、順調な進捗を示す。副産物として外鰓の再生の解析を進めており、こちらも同定した再生誘導物質が効果を発揮することが明らかになってきた。加えて歯の再生も同様のメカニズムで駆動されることも明らかになりつつあり、同定した再生誘導物質の普遍性がより強固に支持されるだけではなく、同定済みの物質の学術的に確実性も担保されると考えられる。

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  • Study of fundamental organ regeneration system

    Grant number：15K14560  2015.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    satoh akira

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    Grant amount：\3900000 （ Direct expense: \3000000 、 Indirect expense：\900000 ）

    In our previous study, we found that BMP7+FGF2+FGF8 can induce limb regeneration. This protein cocktail is actually the limb regeneration inducer in some species. We applied our-defined protein cocktail into other organs. Eye (lens) and tail regeneration were focused. We found that BMP7+FGF2+FGF8 application could induce tail regeneration in urodele amphibians. Regarding to the lens regeneration in an axolotl, the protein combination could induce lens regeneration with very low success rate. However, due to the low induction rate, we still need further confirmation on this point. The detail molecular mechanism, which underlies general organ regeneration ability, has still been unknown.However, the results in the present study successfully provides fundamental insights. We are heading further investigation to identify the molecular entities of organ regeneration ability.

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  • Determination of regeneration inducers in urodele amphibians

    Grant number：26711015  2014.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)  Grant-in-Aid for Young Scientists (A)

    satoh akira

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    Grant amount：\21320000 （ Direct expense: \16400000 、 Indirect expense：\4920000 ）

    This study aims for identification of nerve molecules, which regulate blastema induction phase in amphibian limb regeneration. It has been well described that nerve plays an essential roles in blastema induction. However, identification of nerve factors had not been achieved over 190 years. We approached this issue with a brand-new experimental model called the accessory limb model, which we established recently. What we found in this study was that Fibroblast growth factors (Fgfs) and Bone morphogenic protein (Bmp) could substitute for nerve roles in blastema induction. Moreover, we demonstrated that our defined molecules can induce organ-level regeneration in multiple organs and species.

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  • 両生類四肢再生開始メカニズムの確定とその応用への可能性の探索

    Grant number：25124707  2013.04 - 2015.03

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)

    佐藤 伸

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    Grant amount：\11700000 （ Direct expense: \9000000 、 Indirect expense：\2700000 ）

    有尾両生類は四肢と言う非常に複雑な器官を再生できるが、我々高等脊椎動物は四肢のような複雑な器官はもとより、構造的には比較的単純な器官でさえ再生させることができない。有尾両生類の四肢再生機構を解明し、その機構を高等脊椎動物に応用することが最終的なゴールになる。
    本研究提案内では、先年度目算を付けた再生誘導物質の特定とその応用に焦点を当てている。過剰肢付加モデルと言う世界でも我々しか持たない技術を使用し、再生物質の特定に努めた。結果、FGF2,FGF8,BMP2（７）という3物質が再生誘導物質として確定できることを発見した。皮膚の損傷部に、上記FGF2+FGF8+BMP2を添加することで、有尾両生類（メキシコサラマンダー＆イモリ）で四肢の再生反応を引き起こせることに成功した。FGF2+BMP7、FGF8+BMP7と言った2因子でも再生の誘導は可能ではあったが、その誘導効率は著しい減退を示した。また、BMP4+FGF2+FGF8は全くの効果を持たないことも明らかになった。これらの効果の差は、今後下流因子の関与などの解析するうえでの礎になるものだといえるだろう。この成果は、我々が発見した再生誘導物質が単にメキシコサラマンダーと言う単一種で通用するものではなく、比較的範囲の広い動物に使用できる可能性を提示しているものと考える事ができる。本研究提案内では、損傷部に長期間目的タンパク質を留まらせるための「キャリアー」の改善も行い、今後の他動物（高等脊椎動物）への応用を睨んだ予備的データの収集も行えたことは隠れた大きな成果だと考えられる。

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  • 皮膚繊維芽細胞が多分化能を獲得する分子メカニズムの解明

    Grant number：23124508  2011.04 - 2013.03

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)

    佐藤 伸

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    Grant amount：\11180000 （ Direct expense: \8600000 、 Indirect expense：\2580000 ）

    両生類は四肢を再生できるが、高等脊椎動物は再生できない。この差異はいったい何に起因するのか長い間不明な事項であり、この問題に対する答えはこの分野にとって非常に大きな貢献になる。また、当領域において高等脊椎動物にも相通じる共通の再生原理を見つけることが大切であることから、何が両生類において四肢再生の惹起を担うのかを明らかにすることは大きな意義があると考える。これまでの研究において、四肢再生に必要な四肢の構成成分は「皮膚」と「神経」であることを明らかにした。皮膚の損傷だけでは単純に皮膚の修復が起こるのみである。しかし、皮膚損傷部に神経を遊走させた場合、皮膚修復に替えて、四肢の再生反応が惹起される。これら一連の事項のまとめをまず行いレビュー誌として発表した。このレビューは今までの我々の発見を網羅するもので、考えを整理するうえで大きな成果であると確信している。
    再生反応は「皮膚損傷 + 神経 ＝ 再生」という“再生方程式”で説明できる。この再生方程式を解くため、我々が有する次世代シーケンサーの情報を集約・解析した。その結果、Tgf-bシグナリングの関与を疑うに至った。これまでに他研究で、再生開始にFGF-signalingが重要な働きをしていることは報告してあったが、それだけでは不足であることも合わせて判明していた。そこで加算的な働きをする因子を探していたところ、Tgf-bスーパーファミリー因子の中のGdf5の働きを見出すに至った。このGdf5をFGF-Signalingに加えることで、上記再生方程式の「神経」の部分の回答になりうることを発見した。この知見を高等脊椎動物に生かすべく、現在アフリカツメガエルに応用している最中である。すでに、上記再生方程式が適用できることは見出しており、現在論文にまとめている最中である。今後も随時高等脊椎動物への応用を試みる。

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  • regulations of muscle cells in limb regeneration in axolotl limb regeneration

    Grant number：23770252  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    SATOH Akira

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    Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）

    It has been believed that regenerated limb must be consisted of limb derived cells. But recent our studies imply that muscle cells are not in the case. To investigate whether non-limb derived muscle cells can participate into limb regeneration, we improved our novel experimental system, called the accessory limb model. The improved accessory limb model is an ideal experimental system to investigate limb regeneration. We first revealed dynamics of expression of muscle marker genes. Then, we tested whether tail muscle (non-limb origin) cells could participate into limb regeneration. Our results indicate that non-limb derived muscle cells makes limb muscles in limb regeneration as we expected. Those results are quite useful and insightful for understanding limb regeneration. moreover, our knowledge can provide a novel insights into limb muscle evolution.

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  • first step for limb regeneration in higher vertebrates

    Grant number：21870027  2009 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up  Grant-in-Aid for Research Activity start-up

    SATOU Akira

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    Grant amount：\2756000 （ Direct expense: \2120000 、 Indirect expense：\636000 ）

    We were analyzing about limb regeneration in higher vertebrates. It was not described what happened after limb bud amputation in higher vertebrates. We first described events after limb bud amputation at histology and molecular level. Then we compared regenerative events in an amphibian and a chick. And we know AEC (apical epithelial cap) in an axolotl is the key of amphibian limb regeneration. Therefore, we next focused on AER (Apical epidermal ridge) since AER has been considered to be a functionally similar structure with the AEC. We found that AER was re-inducible after wounding by Wnt2b and Fgf-signaling. Our findings can be thought as a first step for mammalian limb regeneration.

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Class subject in charge

  • Regeneration Biology （2024academic year） Late  - その他

  • Seminar in Organ Regeneration Biology （2024academic year） Other  - その他

  • Seminar in Organ Regeneration Biology （2024academic year） Year-round  - その他

  • Organ Regeneration Biology （2024academic year） Late  - 木1～2

  • Seminar in Developmental Biology （2024academic year） Year-round  - その他

  • Developmental　Biology　Ⅰ （2024academic year） 3rd and 4th semester  - 月1～2

  • Developmental Biology IB （2024academic year） Fourth semester  - 月1～2

  • Developmental Biology IA （2024academic year） Third semester  - 月1～2

  • Regeneration Biology （2023academic year） Late  - その他

  • Regeneration Biology （2023academic year） Late  - その他

  • Seminar in Organ Regeneration Biology （2023academic year） Other  - その他

  • Organ Regeneration Biology （2023academic year） Late  - 木1～2

  • Organ Regeneration Biology （2023academic year） Late  - 木1～2

  • Seminar in Developmental Biology （2023academic year） Year-round  - その他

  • Seminar in Developmental Biology （2023academic year） Year-round  - その他

  • Developmental　Biology　Ⅰ （2023academic year） 3rd and 4th semester  - 月1～2

  • Developmental Biology IB （2023academic year） Fourth semester  - 月1～2

  • Developmental Biology IA （2023academic year） Third semester  - 月1～2

  • Regeneration Biology （2022academic year） Late  - その他

  • Molecular Biology IIA （2022academic year） 1st semester  - 火3～4

  • Molecular Biology IIB （2022academic year） Second semester  - 火3～4

  • Organ Regeneration Biology （2022academic year） Late  - 木1～2

  • Experiments in Basic Biology （2022academic year） Summer concentration  - その他

  • Experiments in Basic Biology （2022academic year） Summer concentration  - その他

  • Seminar in Developmental Biology （2022academic year） Year-round  - その他

  • Genetics and Molecular Biology （2021academic year） Fourth semester  - 金7,金8

  • Regeneration Biology （2021academic year） Late  - その他

  • 分子から生命体へ （2021academic year） 第３学期

  • Molecular Biology 2 （2021academic year） 1st and 2nd semester  - 火3,火4

  • Molecular Biology IIA （2021academic year） 1st semester  - 火3,火4

  • Molecular Biology IIB （2021academic year） Second semester  - 火3,火4

  • Organ Regeneration Biology （2021academic year） Late  - 木1,木2

  • 生物学実験Ａ （2021academic year） １・２学期

  • Seminar in Developmental Biology （2021academic year） Year-round  - その他

  • Genetics and Molecular Biology （2020academic year） Fourth semester  - 金7,金8

  • Regeneration Biology （2020academic year） Late  - その他

  • Molecular Biology 2 （2020academic year） 1st and 2nd semester  - 火3,火4

  • Molecular Biology IIA （2020academic year） 1st semester  - 火3,火4

  • Molecular Biology IIB （2020academic year） Second semester  - 火3,火4

  • Organ Regeneration Biology （2020academic year） Late  - 木1,木2

  • Seminar in Developmental Biology （2020academic year） Year-round  - その他

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Social Activities

  • 次世代理系人材育成プログラム

    Role(s)：Lecturer

    2024.11.10

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    Type：Visiting lecture

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  • 「集まれ！理系女子」女子生徒による科学研究発表（第４回九州大会）Ｗｅｂ交流会

    Role(s)：Commentator,　Advisor

    2021.9.20

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    Type：Seminar, workshop

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  • 「集まれ！理系女子」女子生徒による科学研究発表

    Role(s)：Commentator,　Advisor

    2020.9.19

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    Type：Seminar, workshop

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  • 再生生物学 基礎科学コース

    Role(s)：Lecturer,　Advisor

    ノートルダム清心女子高校  2015.1.19

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    Type：Lecture

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Media Coverage

  • Une découverte chez l'axolotl remet en cause l'efficacité des soins pour la peau Internet

    Sciences et avenir (France)  Sciences et avenir (France)  https://www.sciencesetavenir.fr/sante/dermato/une-decouverte-chez-l-axolotl-remet-en-cause-l-efficacite-des-soins-pour-la-peau_184725  2025.3.21

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  • コラーゲン 表皮細胞での生成判明 岡山大院生 ウーパールーパー研究 Newspaper, magazine

    山陽新聞  山陽新聞  2025.3.17

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  • 肌に張りもたらすコラーゲン、「作られる仕組み」ウーパールーパーで解明…化粧品開発につながる可能性 Newspaper, magazine

    読売新聞  2025.3.17

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  • ウーパールーパーの皮膚を研究 コラーゲンの供給源は…岡山大の大学院生らが解明 Internet

    KSB瀬戸内海放送  2025.2

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  • （ラジオ放送）RSKラジオ生放送番組「天神ワイド朝」 TV or radio program

    RSK放送局  2024.2.22

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    Author：Myself 

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  • （ラジオ放送）RSKラジオ 技術の森

    RSK放送局  RSKラジオ 技術の森  2022.7.6

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  • 研究記事紹介

    科学新聞  科学新聞  4面  2022.7

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  • （ラジオ放送）RSKラジオ 技術の森

    RSK放送局  RSKラジオ 技術の森  2022.6.29

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  • （取材協力）

    TBS  Nスタ  2020.3.10

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  • せとうち経済チア部 すてき未来研究所

    テレビせとうち  2020.2

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    Author：Other 

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  • （会津河東小学校での公演紹介） Newspaper, magazine

    福島放送・福島民友新聞  2018.6.29

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  • （子供新聞インタビュー）

    山陽新聞  2017.9.6

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    Author：Other 

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  • （研究室紹介）

    日本経済新聞  日本経済新聞  2017.3.19

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  • テレビ朝日「池上彰2016総ざらい 今年のニュースとあのニュースの今!? 年末4時間SP」 過剰肢モデルと研究紹介

    テレビ朝日  2016.12.29

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  • （Newtonに記事紹介）

    Newton  2016.12

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  • 科学欄「ミチをひらく」 Newspaper, magazine

    朝日新聞  2015.9.15

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  • （取材協力）

    日本テレビ  日本テレビ「一撃解明バラエティ ひと目でわかる!!」「ウーパールーパーの誕生」 

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Academic Activities

  • TSB WORKSHOP オーガナイザー

    Role(s)：Planning, management, etc.

    亀井保博・佐藤伸・安齋賢  2025.3.3 - 2025.3.4

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    Type：Academic society, research group, etc. 

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  • International meeting Organizer

    Role(s)：Planning, management, etc.

    Toshinori hayashi, Hajime Ogino, and Akira Satoh  2024.7.31 - 2024.8.2

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    Type：Academic society, research group, etc. 

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  • 招待講演「両生類を用いた皮膚科学」

    2021.9.20

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    Type：Academic society, research group, etc. 

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  • 図鑑ヒトの細胞

    2021.6.8

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  • 次世代両生類会議 （＠基礎生物学研究所）

    Role(s)：Planning, management, etc.,　Panel moderator, session chair, etc.

    佐藤伸  2017.8.24 - 2017.8.25

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    Type：Competition, symposium, etc. 

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  • （高校生むけ研究アウトリーチ活動） 展示・研究紹介

    再生医療学会  2017.3.9

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  • Regeneration in Zoology

    Role(s)：Planning, management, etc.

    2016.11.17

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    Type：Competition, symposium, etc. 

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  • 集中講義

    北海道大学 栃内新  2015.2.12 - 2015.2.15

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  • 基礎生物学研究所 トレーニングコース 講師

    2013.8.30

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    Type：Academic society, research group, etc. 

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  • Symposium on Interdisciplinary Researches in Okayama

    Role(s)：Planning, management, etc.,　Panel moderator, session chair, etc.

    2012.11.20

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    Type：Competition, symposium, etc. 

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  • International Meeting：Limb regeneration

    Role(s)：Planning, management, etc.,　Panel moderator, session chair, etc.

    2012.11.19

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    Type：Academic society, research group, etc. 

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  • IDE Work Shopの主催

    Role(s)：Planning, management, etc.,　Panel moderator, session chair, etc.

    2012.4.5

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    Type：Academic society, research group, etc. 

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