研究者詳細 - 鷲尾　佳奈

論文 - 鷲尾　佳奈

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免疫異常骨髄異形成症候群と大腸多発癌を合併した先天性角化不全症の1例(Immune disorder A case of dyskeratosis congenita developed myelodysplastic syndrome and multiple colon cancer)

尾山貴徳, 野田卓男, 納所洋, 谷本光隆, 石田悠志, 金光喜一郎, 鷲尾佳奈, 長谷川高誠, 田中弘之, 神崎洋光, 永坂岳司, 嶋田明

日本小児血液・がん学会雑誌 52 ( 4 ) 214 - 214 2015年10月

甲状腺乳頭がん・多発肺転移に対してsorafenibを用いた自閉症スペクトラムの11歳男児の1例(Using sorafenib in pediatric patient with papillary thyroid carcinoma with diffuse lung metastases: A case of 11-years-old boy with autism)

樋口洋介, 石田悠志, 金光喜一郎, 鷲尾佳奈, 嶋田明, 野田卓男, 尾山貴徳, 元木崇之

日本小児血液・がん学会雑誌 52 ( 4 ) 376 - 376 2015年10月

Suspected early onset of congenital Langerhans cell histiocytosis involving ectopic cervical thymus and mediastinal thymus, simultaneously. 国際誌

Kiichiro Kanamitsu, Kana Washio, Megumi Oda, Takuo Noda, Takanori Oyama, Terutaka Tanimoto, Takehiro Tanaka, Kentaro Ida, Akira Shimada

Pediatric blood & cancer 62 ( 8 ) 1491 - 2 2015年8月

ABL kinase mutation and relapse in 4 pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia cases.

Michinori Aoe, Akira Shimada, Michiko Muraoka, Kana Washio, Yoshimi Nakamura, Takahide Takahashi, Masahide Imada, Toshiyuki Watanabe, Ken Okada, Ritsuo Nishiuchi, Takako Miyamura, Kosuke Chayama, Misako Shibakura, Megumi Oda, Tsuneo Morishima

International journal of hematology 99 ( 5 ) 609 - 15 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）

The tyrosine kinase inhibitor (TKI) imatinib mesylate (IM) revolutionized the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL), which had showed poor prognosis before the dawn of IM treatment. However, if Ph-ALL patients showed IM resistance due to ABL kinase mutation, second-generation TKI, dasatinib or nilotinib, was recommended. We treated 4 pediatric Ph-ALL patients with both IM and bone marrow transplantation (BMT); however, 3 relapsed. We retrospectively examined the existence of ABL kinase mutation using PCR and direct sequencing methods, but there was no such mutation in all 4 diagnostic samples. Interestingly, two relapsed samples from patients who were not treated with IM before relapse did not show ABL kinase mutation and IM was still effective even after relapse. On the other hand, one patient who showed resistance to 3 TKI acquired dual ABL kinase mutations, F359C at the IM-resistant phase and F317I at the dasatinib-resistant phase, simultaneously. In summary, Ph-ALL patients relapsed with or without ABL kinase mutation. Furthermore, ABL kinase mutation was only found after IM treatment, so an IM-resistant clone might have been selected during the IM treatment and intensive chemotherapy. The appropriate combination of TKI and BMT must be discussed to cure Ph-ALL patients.

DOI： 10.1007/s12185-014-1565-3

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Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia. 国際誌

Naoto Morishita, Hirokazu Tsukahara, Kosuke Chayama, Toshiaki Ishida, Kana Washio, Takako Miyamura, Nobuko Yamashita, Megumi Oda, Tsuneo Morishima

Pediatric blood & cancer 59 ( 1 ) 83 - 9 2012年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway, a pro-survival pathway, plays important roles in tumor cell growth. However, the role of Akt in the pathogenesis of pediatric B-precursor acute lymphoblastic leukemia (B-pre ALL) remains to be clarified. This study was undertaken to explore the clinical relevance and molecular mechanisms underlying the activation of Akt (i.e., phosphorylated Akt, P-Akt) in pediatric B-pre ALL. PROCEDURE: We evaluated the activation status of Akt in bone marrow samples from 21 children with newly diagnosed B-pre ALL and correlated the expression level of P-Akt with clinicopathologic and prognostic features. Additionally, we transfected the myristoylated Akt cDNA into the B-pre ALL cell line, Nalm-6, and examined the effect, in vitro, of Akt activation on the response to antitumor drugs. RESULTS: P-Akt expression in B-pre ALL blast cells at diagnosis was associated significantly with poor response to induction chemotherapy including prednisolone, dexamethasone, vincristine, and adriamycin in B-pre ALL patients. Both overall survival and relapse-free survival in patients with P-Akt expression were reduced significantly more than in patients without P-Akt expression. Activation of Akt reduced the extent of apoptosis induced by the antitumor drugs in Nalm-6 listed above. Activation of Akt did not induce expression of P-glycoprotein, a drug transporter that is capable of conferring multidrug resistance. CONCLUSION: These results support the contention that Akt activation is a mechanism of chemotherapeutic resistance in B-pre ALL and suggest that Akt can be a therapeutic target for the treatment of relapsed or refractory pediatric B-pre ALL.

DOI： 10.1002/pbc.24034

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Successful treatment of unresectable advanced hepatoblastoma: living liver transplantation after surgical removal of lung metastasis. 国際誌

Takako Miyamura, Ryuichi Yoshida, Takahito Yagi, Hiroyoshi Matsukawa, Kousuke Chayama, Toshiaki Ishida, Kana Washio, Naoto Morishita, Megumi Oda, Tsuneo Morishima

Pediatric transplantation 15 ( 5 ) E87-91 2011年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Hepatoblastoma is a rare malignant tumor of the liver in children. Intensive combination chemotherapy has increased the number of surgically resectable cases and improved prognosis markedly. However, unresectable cases and cases with residual metastasis, including lung metastases, have a poor prognosis. In these refractory cases, treatment strategy has not been established. On the other hand, living liver transplantation has been shown to be effective in cases of advanced hepatoblastoma, but its effectiveness in cases with residual distant metastases after chemotherapy remains unclear. We report one successful case of advanced unresectable hepatoblastoma with multiple lung metastases. Intensive chemotherapy consisting of high-dose chemotherapy with autologous hematopoietic stem cell transplantation was not effective. We performed living liver transplantation after surgical resection of residual lung metastases, which were histologically viable. After liver transplantation, the level of tumor marker decreased gradually. The patient experienced no severe complications. This case suggested that living liver transplantation could be effective in cases of advanced refractory hepatoblastoma after control of distant metastases.

DOI： 10.1111/j.1399-3046.2009.01262.x

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Cumulative kinetics of epigenetic abnormalities during initiation and progression of Adult T-cell Leukemia/Lymphoma (ATLL).

Oka T, Sato H, Al-Kader LA, Shinnou Y, Washio K, Takata K, Murakami I, Utsunomiya A, Ouchida M, Takahashi K, Yoshino T

Retrovirology 2011年6月

Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma. 国際誌

Hiaki Sato, Takashi Oka, Yoko Shinnou, Takami Kondo, Kana Washio, Masayuki Takano, Katsuyoshi Takata, Toshiaki Morito, Xingang Huang, Maiko Tamura, Yuta Kitamura, Nobuya Ohara, Mamoru Ouchida, Koichi Ohshima, Kenji Shimizu, Mitsune Tanimoto, Kiyoshi Takahashi, Masao Matsuoka, Atae Utsunomiya, Tadashi Yoshino

The American journal of pathology 176 ( 1 ) 402 - 15 2010年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Aberrant CpG island methylation contributes to the pathogenesis of various malignancies. However, little is known about the association of epigenetic abnormalities with multistep tumorigenic events in adult T cell leukemia/lymphoma (ATLL). To determine whether epigenetic abnormalities induce the progression of ATLL, we analyzed the methylation profiles of the SHP1, p15, p16, p73, HCAD, DAPK, hMLH-1, and MGMT genes by methylation specific PCR assay in 65 cases with ATLL patients. The number of CpG island methylated genes increased with disease progression and aberrant hypermethylation in specific genes was detected even in HTLV-1 carriers and correlated with progression to ATLL. The CpG island methylator phenotype (CIMP) was observed most frequently in lymphoma type ATLL and was also closely associated with the progression and crisis of ATLL. The high number of methylated genes and increase of CIMP incidence were shown to be unfavorable prognostic factors and correlated with a shorter overall survival by Kaplan-Meyer analysis. The present findings strongly suggest that the multistep accumulation of aberrant CpG methylation in specific target genes and the presence of CIMP are deeply involved in the crisis, progression, and prognosis of ATLL, as well as indicate the value of CpG methylation and CIMP for new diagnostic and prognostic biomarkers.

DOI： 10.2353/ajpath.2010.090236

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Multi-step accumulation of aberrant CpG island hypermethylation during progression of lymphoma/leukemia

Takashi Oka, Takami Kondo, Hiaki Sato, Yoko Nakatani, Kana Washio, Ichiro Murakami, Nobuya Ohara, Kiyoshi Takahashi, Mamoru Ouchida, Mitsune Tanimoto, Tadashi Yoshino

International Journal of Molecular Medicine 26 ( Sup1 ) S44 - S44 2010年

IMMUNOHISTOCHEMICAL ANALYSES OF PTPN6 (SHP1) IN LANGERHANS CELL HISTIOCYTOSIS 査読

Ichiro Murakami, Takashi Oka, Hiaki Sato, Toshiaki Morito, Katsuyoshi Takata, Yoko Shinno, Masayuki Takano, Kana Washio, Shingo Ko, Maiko Tamura, Naoko Ohnishi, Koichi Ichimura, Yasuharu Sato, Hiroyuki Yanai, Nobuya Ohara, Eisaku Kondo, Kiyoshi Takahashi, Takehiro Tanaka, Jean Gogusev, Francis Jaubert, Akira Morimoto, Shinsaku Imashuku, Tadaatsu Akagi, Tadashi Yoshino

PEDIATRIC BLOOD & CANCER 53 ( 4 ) 691 - 691 2009年10月

Accumulation of aberrant CpG hypermethylation by Helicobacter pylori infection promotes development and progression of gastric MALT lymphoma. 国際誌

Takami Kondo, Takashi Oka, Hiaki Sato, Yoko Shinnou, Kana Washio, Masayuki Takano, Toshiaki Morito, Katsuyoshi Takata, Nobuya Ohara, Mamoru Ouchida, Kenji Shimizu, Tadashi Yoshino

International journal of oncology 35 ( 3 ) 547 - 57 2009年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Aberrant DNA hypermethylation is an important mechanism for the inactivation of tumor-related genes in human tumors. Gastric mucosa-associated lymphoid tissue (MALT) lymphomas arise from Helicobacter pylori-associated chronic gastritis; most patients are H. pylori-positive and eradication therapy is highly effective. In the present study, we used methylation-specific PCR to analyze the DNA methylation status of 11 tumor-related genes (Kip2, p16, hMLH-1, p15, p73, MGMT, DAPK, MINT1, MINT2, MINT31 and HCAD) in 21 specimens of MALT lymphoma, 5 specimens of MALT lymphoma with large cell component (high-grade MALT lymphoma), 15 specimens of diffuse large B-cell lymphoma (DLBCL), 8 specimens of complete remission of MALT lymphoma after eradication therapy, 5 specimens with no evidence of malignancy and PBMCs from 10 healthy donors. The average number of methylated genes was significantly greater in gastric lymphomas as compared to normal controls (P<0.001). The CpG island methylator phenotype (CIMP) was observed in 93.3% (14/15) of DLBCLs, 100% (5/5) of high-grade MALT lymphomas and 61.9% (13/21) of MALT lymphomas; in contrast, CIMP was not found in the control group (0%). The average number of methylated genes and the CIMP incidence significantly increased with H. pylori infection. Furthermore, aberrant CpG methylation of specific genes, such as p16, MGMT and MINT31, was consistently associated with H. pylori infection. These findings strongly suggest that H. pylori infection causes the aberrant DNA hypermethylation of specific genes and induces CIMP, which is an important epigenetic mechanism for the development and progression of gastric MALT lymphoma; additionally, our findings provide new epigenetic markers.

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Two cases of chronic active Epstein-Barr virus infection in which EBV-specific cytotoxic T lymphocyte was induced after allogeneic bone marrow transplantation. 国際誌

Takako Miyamura, Kousuke Chayama, Tomoaki Wada, Kazunari Yamaguchi, Nobuko Yamashita, Toshiaki Ishida, Kana Washio, Naoto Morishita, Akira Manki, Megumi Oda, Tsuneo Morishima

Pediatric transplantation 12 ( 5 ) 588 - 92 2008年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

CAEBV is a high mortality and morbidity disease with life-threatening complications. Nevertheless, the treatment regimens for CAEBV have not yet been established. Although some reports have described CAEBV therapy involving treatments such as antiviral drugs, immunomodulatory agents, and immunochemotherapy, none of these treatments have been demonstrated to be effective. The only treatment reported to be effective is allogeneic SCT. However, the complications of SCT are severe, so treatment results have been poor. Recently, immunotherapy has been devised, but this is still in the developmental stage. In this report, two cases of CAEBV in which allogeneic SCT was performed soon after diagnosis are reported. In both cases, a high EBV genome titer in the peripheral blood was detected at onset. After SCT, the EBV genome titer decreased as CTL activity gradually increased. This fact suggested that not only high-dose chemotherapy as a preconditioning treatment of SCT but also increased CTL activity which could eliminate virus-infected cells might be effective, although additional cases should be studied in order to establish effective treatments.

DOI： 10.1111/j.1399-3046.2007.00873.x

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Longitudinal analysis of Epstein-Barr virus-associated illness. 国際誌

Nobuko Yamashita, Kosuke Chayama, Takako Miyamura, Tomoaki Wada, Hidehiko Maruyama, Kana Washio, Takayuki Miyai, Tsuneo Morishima

Pediatrics international : official journal of the Japan Pediatric Society 50 ( 3 ) 388 - 91 2008年6月

Epigenetically distinct malignant cell population forms lymphoma-involving lesions in acute type adult T cell Leukemia/Lymphoma (ATLL)

Takashi Oka, Hiaki Sato, Yoko Nakatani, Takami Kondo, Kana Washio, Masayuki Takano, Ichiro Murakami, Nobuya Ohara, Mamoru Ouchida, Koichi Ohshima, Kenji Shimizu, Mitsune Tanimoto, Kiyoshi Takahashi, Atae Utsunomiya, Tadashi Yoshino

AIDS RESEARCH AND HUMAN RETROVIRUSES 23 ( 4 ) 627 - 628 2007年4月

Molecular pathological analysis of the protein tyrosine phosphatase: SHP1 gene in the pathogenesis of lymphoma and leukemias

Takashi Oka, Yoko Nakatani, Takami Kondo, Hiaki Sato, Kana Washio, Masayuki Takano, Ichirou Murakami, Yuriko Nishikawa, Mamoru Ouchida, Nobuya Ohara, Kiyoshi Takahashi, Kazuhiko Hayashi, Mitsune Tanimoto, Kenji Shimizu, Tadashi Yoshino

CANCER RESEARCH 66 ( 8 ) 2006年4月

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