研究者詳細 - 鷲尾　佳奈

論文 - 鷲尾　佳奈

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Long-term Remission of Hepatitis-associated Aplastic Anemia Possibly due to Immunosuppressive Therapy after Liver Transplantation.

Kiichiro Kanamitsu, Kousuke Chayama, Kana Washio, Ryuichi Yoshida, Yuzo Umeda, Takahito Yagi, Akira Shimada

Acta medica Okayama 72 ( 5 ) 515 - 518 2018年10月

記述言語：英語

Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living-donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient's bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis.

DOI： 10.18926/AMO/56250

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Simultaneous detection of ABL1 mutation and IKZF1 deletion in Philadelphia chromosome-positive acute lymphoblastic leukemia using a customized target enrichment system panel

M. Aoe, H. Ishida, T. Matsubara, S. Karakawa, H. Kawaguchi, K. Fujiwara, K. Kanamitsu, K. Washio, K. Okada, M. Shibakura, A. Shimada

International Journal of Laboratory Hematology 40 ( 4 ) 427 - 436 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Blackwell Publishing Ltd

Introduction: Recent clinical outcomes of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) vastly improved owing to tyrosine kinase inhibitor (TKI). However, the genetic status would be different in each case with ABL1 gene mutation or copy number variants (CNVs) such as IKZF1 deletion. In particular, the TKI resistant clone with ABL1 kinase mutation remains problematic. The comprehensive assessment of genetic status including mutation, insertion and deletion (indel) and CNVs is necessary. Methods: We evaluated a next-generation sequencing (NGS)-based customized HaloPlex target enrichment system panel to simultaneously detect coding mutations, indel and CNVs. We analysed approximately 160 known genes associated with hematological disorders in 5 pediatric Ph+ALL patients. Results: Mono-allelic IKZF1 deletions were found in 4 patients at diagnosis. Furthermore, the mono-allelic deletions were found in exons of RB1, EBF1, PAX5 and ETV6 genes. Bi-allelic deletions were detected in CDKN2A and CDKN2B genes in 1 patient. ABL1 mutation was also detected in 1 patient at relapse. These results were almost comparable with the results of the multiplex ligation-dependent probe amplification (MLPA) method or Sanger sequence. Conclusion: Next-generation sequencing-based custom HaloPlex target enrichment system panel allows us to detect the coding mutations, indel, and CNVs in pediatric Ph+ALL simultaneously, and its results seem comparable with those of other methods.

DOI： 10.1111/ijlh.12805

尾山貴徳, 野田卓男, 谷守通, 納所洋, 谷本光隆, 岩本貴行, 元木崇之, 樋口洋介, 藤原かおり, 石田悠志, 金光喜一郎, 鷲尾佳奈, 嶋田明

日本小児血液・がん学会雑誌 54 ( 3 ) 275 - 275 2017年12月

Sorafenib treatment for papillary thyroid carcinoma with diffuse lung metastases in a child with autism spectrum disorder: a case report. 国際誌

Yousuke Higuchi, Takayuki Motoki, Hisashi Ishida, Kiichiro Kanamitsu, Kana Washio, Takanori Oyama, Takuo Noda, Yasuko Tsurumaru, Ayumi Okada, Hirokazu Tsukahara, Akira Shimada

BMC cancer 17 ( 1 ) 775 - 775 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Pediatric papillary thyroid carcinoma frequently presents with lymph node involvement and distant metastases. Sorafenib, an oral multikinase inhibitor, has been used to treat radioactive iodine (RAI) therapy-refractory thyroid carcinoma in adults; however, pediatric experience is limited. Medical procedures and hospitalization for children with autism spectrum disorder may be challenging. CASE PRESENTATION: An 11-year-old boy with autism spectrum disorder and moderate intellectual impairment presented with dyspnea on exertion with thyroid carcinoma and diffuses lung metastases. Total thyroidectomy and adjuvant RAI therapy is the standard treatment; however, the latter therapy was impractical because of his respiratory status and challenging behaviors. He was therefore started on sorafenib 200 mg/day (150 mg/m2/day) and this dosage was increased to 400 mg/day (300 mg/m2/day). The adverse effects were mild and tolerable. After administration of medication, his dyspnea improved and surgery was performed. We attempted to administer RAI therapy after surgery; however, we abandoned it because he had difficulty taking care of himself according to isolation room rules. Thyrotropin suppression therapy was therefore started and sorafenib treatment (400 mg/day) resumed. Follow-up imaging showed regression of pulmonary metastases. The metastases have remained stable for over 24 months on continuous sorafenib treatment without serious adverse events. CONCLUSION: We inevitably used sorafenib as an alternative to standard therapy because of the patient's specific circumstances. Individualized strategies for pediatric cancer patients with autism spectrum disorder are needed.

DOI： 10.1186/s12885-017-3782-7

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Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia. 国際誌

Kana Washio, Takashi Oka, Lamia Abdalkader, Michiko Muraoka, Akira Shimada, Megumi Oda, Hiaki Sato, Katsuyoshi Takata, Yoshitoyo Kagami, Norio Shimizu, Seiichi Kato, Hiroshi Kimura, Kazunori Nishizaki, Tadashi Yoshino, Hirokazu Tsukahara

Leukemia & lymphoma 58 ( 11 ) 2683 - 2694 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

The human herpes virus, Epstein-Barr virus (EBV), is a known oncogenic virus and plays important roles in life-threatening T/NK-cell lymphoproliferative disorders (T/NK-cell LPD) such as hypersensitivity to mosquito bite (HMB), chronic active EBV infection (CAEBV), and NK/T-cell lymphoma/leukemia. During the clinical courses of HMB and CAEBV, patients frequently develop malignant lymphomas and the diseases passively progress sequentially. In the present study, gene expression of CD16(-)CD56(+)-, EBV(+) HMB, CAEBV, NK-lymphoma, and NK-leukemia cell lines, which were established from patients, was analyzed using oligonucleotide microarrays and compared to that of CD56brightCD16dim/- NK cells from healthy donors. Principal components analysis showed that CAEBV and NK-lymphoma cells were relatively closely located, indicating that they had similar expression profiles. Unsupervised hierarchal clustering analyses of microarray data and gene ontology analysis revealed specific gene clusters and identified several candidate genes responsible for disease that can be used to discriminate each category of NK-LPD and NK-cell lymphoma/leukemia.

DOI： 10.1080/10428194.2017.1304762

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多彩な合併症を呈するBeckwith-Wiedemann症候群に発症した乳児肝芽腫の一例

尾山貴徳, 野田卓男, 谷守通, 納所洋, 谷本光隆, 谷和祐, 石田悠志, 岡村朋香, 藤原かおり, 金光喜一郎, 鷲尾洋介, 鷲尾佳奈, 吉本順子, 嶋田明

日本小児血液・がん学会雑誌 54 ( 4 ) 333 - 333 2017年10月

A Case of Refractory Langerhans Cell Histiocytosis Complicated with Hemophagocytic Lymphohistiocytosis Rescued by Cord Blood Transplantation with Reduced-intensity Conditioning.

Kana Washio, Michiko Muraoka, Kiichiro Kanamitsu, Megumi Oda, Akira Shimada

Acta medica Okayama 71 ( 3 ) 249 - 254 2017年6月

記述言語：英語

We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.

DOI： 10.18926/AMO/55208

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Desmoid-type fibromatosis in a boy with Down syndrome. 国際誌

Hisashi Ishida, Kousuke Chayama, Kiichiro Kanamitsu, Kana Washio, Takehiro Tanaka, Akira Shimada

Pediatrics international : official journal of the Japan Pediatric Society 59 ( 5 ) 624 - 626 2017年5月

記述言語：英語

Patients with Down syndrome (DS) have a markedly higher incidence of childhood leukemia, but a lower incidence of most solid tumors, compared with age-matched euploid individuals. Trisomy 21 might be protective against tumorigenesis because of several tumor suppressive mechanisms. Desmoid-type fibromatosis (DF) is a rare monoclonal, fibroblastic proliferation characterized by a variable clinical course. In recent reports, almost all cases of DF involved genomic alterations associated with activation of the Wnt/β-catenin pathway. Here, we report the case of a boy with DS who developed DF without activation of the Wnt/β-catenin pathway. To the best of our knowledge, this is the first case of DS involving DF.

DOI： 10.1111/ped.13241

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[Prognostic Impact of Radiation Therapy and Molecular Classification of Infant Atypical Teratoid/Rhabdoid Tumors].

Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Takao Yasuhara, Kana Washio, Akira Shimada, Norihisa Katayama, Kuniaki Katsui, Hiroyuki Yanai, Isao Date

No shinkei geka. Neurological surgery 45 ( 2 ) 147 - 154 2017年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Atypical teratoid/rhabdoid tumor(AT/RT)is a rare and lethal childhood cancer. Although radiation therapy in children less than three years of age is generally deferred because of its neural toxicity, recent studies have shown that multimodal therapies, including radiation therapy, are effective in pediatric patients with AT/RT less than three years of age. We treated four infant AT/RT patients and investigated the impact of radiation therapy and genetic classification on the prognosis. The mean age at the time of the operation was 9.3 months and all patients were female. All patients underwent surgical resection. Of the four patients, two received combined irradiation and chemotherapy. Specifically, one patient received conformal craniospinal radiation therapy and the other received craniospinal irradiation with proton beams. Immunohistochemical analyses of tumor specimens revealed that the two patients were positive for ASCL1, a regulator of Notch signaling. Patients who received radiation therapy and exhibited ASCL1-positive tumors had a better prognosis. We conclude that radiation therapy may prolong survival in AT/RT patients who are less than 3 years of age. However, further study is required to evaluate long-term functional outcomes.

DOI： 10.11477/mf.1436203466

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Two Relapsed Stage III Childhood Anaplastic Large Cell Lymphoma Patients with NPM-ALK Fusion in Bone Marrow from Initial Diagnosis.

Yui Kanazawa, Yuka Yamashita, Mitsuhiro Fujiwara, Michiko Muraoka, Kana Washio, Kiichiro Kanamitsu, Hisashi Ishida, Takae Nakano, Miho Yamada, Keizo Horibe, Takehiro Tanaka, Tadashi Yoshino, Akira Shimada

Acta medica Okayama 70 ( 6 ) 503 - 506 2016年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10-30% of cases of non-Hodgkin lymphoma, and the ALCL99 study reported 60-75 disease-free survival; however, a relatively high relapse rate was observed (25-30% ). We report 2 patients with Stage III ALCL who relapsed 6-18 months after the end of ALCL99 chemotherapy. A retrospective molecular analysis identified the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion gene in the first diagnostic bone marrow samples taken from both patients. However, antibodies against the ALK protein appeared to be relatively low in the serum of both patients (×100 and ×750). An increase in chemotherapy intensity may be beneficial if Stage III ALCL patients are shown to be NPM-ALK chimera-positive in the first diagnostic bone marrow sample.

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化学療法を行った先天性全身型黄色肉芽腫症の一例(A case of congenital systemic juvenile xanthogranuloma treated with chemotherapy)

金光喜一郎, 石田悠志, 藤原かおり, 鷲尾佳奈, 田中健大, 嶋田明

日本小児血液・がん学会雑誌 53 ( 4 ) 245 - 245 2016年11月

Relapsed infant MLL-rearranged acute lymphoblastic leukemia with additional genetic alterations. 国際誌

Hisashi Ishida, Kiichiro Kanamitsu, Kana Washio, Michiko Muraoka, Kanae Sakakibara, Takehiro Matsubara, Hirotaka Kanzaki, Akira Shimada

Pediatric blood & cancer 63 ( 11 ) 2059 - 60 2016年11月

MIBG陰性神経芽腫に対するFDG-PETの有用性(Value of FDG-PET for the assessment of treatment efficacy in MIBG-negative neuroblastoma patients)

尾山貴徳, 野田卓男, 谷守通, 納所洋, 谷本光隆, 藤原かおり, 石田悠志, 金光喜一郎, 鷲尾佳奈, 嶋田明

日本小児血液・がん学会雑誌 53 ( 4 ) 231 - 231 2016年11月

Adults with germline CBL mutation complicated with juvenile myelomonocytic leukemia at infancy. 国際誌

Michiko Muraoka, Chiho Okuma, Kiichiro Kanamitsu, Hisashi Ishida, Yui Kanazawa, Kana Washio, Masafumi Seki, Motohiro Kato, Junko Takita, Yusuke Sato, Seishi Ogawa, Hirokazu Tsukahara, Megumi Oda, Akira Shimada

Journal of human genetics 61 ( 6 ) 523 - 6 2016年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Juvenile myelomonocytic leukemia (JMML) appears to be a life-threatening disease and showed poor prognosis even after hematopoietic stem cell transplantation (HSCT) because of high relapse rate. On the other hand, recent molecular analysis revealed the heterogeneity of JMML. Here we report that two JMML patients survived >20 years without HSCT and both patients had uniparental disomy of 11q23 where CBL is located without the phenomenon found in neither Noonan syndrome nor Noonan syndrome-like disorder. We think that some JMML patients with CBL mutation might show the good prognosis in later life after remission of JMML.

DOI： 10.1038/jhg.2016.8

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Persistent clonal chromosomal abnormalities in a chronic myeloid leukemia patient. 国際誌

Michiko Muraoka, Kana Washio, Kiichiro Kanamitu, Yui Kanazawa, Toshiaki Ishida, Takako Miyamura, Kosuke Chayama, Ritsuo Nishiuchi, Megumi Oda, Akira Shimada

Pediatrics international : official journal of the Japan Pediatric Society 58 ( 1 ) 53 - 6 2016年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Clonal cytogenetic abnormalities (CCA) in Philadelphia chromosome (Ph)-negative cells have been reported in a small population of adult chronic myelogenous leukemia (CML) patients during the clinical course, but CCA in pediatric CML patients are rarely reported. We herein report the case of an 8-year-old boy from the onset of CML. Although he had relapse after unrelated bone marrow transplantation when 9 years old, he has since been in complete molecular response on imatinib mesylate treatment. Surprisingly, various CCA have been observed in this patient, including several reciprocal chromosomal translocations in Ph-negative cells for >12 years. Although dysplasia in the bone marrow cells was identified, no overt transformation to myelodysplastic syndrome or acute myeloid leukemia has been observed. The cause of the CCA remains unknown in this patient, and careful observation is required.

DOI： 10.1111/ped.12739

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A Long-term Survivor after Congenital Acute Myeloid Leukemia with t(8 ; 16)(p11 ; p13).

Takae Hanada, Kiichiro Kanamitsu, Kosuke Chayama, Takako Miyamura, Yui Kanazawa, Michiko Muraoka, Kana Washio, Masahide Imada, Misao Kageyama, Akihito Takeuchi, Kei Tamai, Megumi Oda, Akira Shimada

Acta medica Okayama 70 ( 1 ) 31 - 5 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）

The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8 ; 16) (p11 ; p13) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ-CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ-CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ-CBP in the pediatric population might show better prognoses.

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頸部異所性胸腺と縦隔内胸腺に同時発生したLangerhans cell histiocytosisの1例

納所洋, 野田卓夫, 尾山貴徳, 谷本光隆, 金光喜一郎, 鷲尾佳奈, 嶋田明, 小田慈

日本小児血液・がん学会雑誌 52 ( 3 ) 339 - 339 2015年10月

先天性角化不全症に合併した多発肝転移を伴う横行結腸癌の1例

尾山貴徳, 野田卓男, 納所洋, 谷本光隆, 金光喜一郎, 鷲尾佳奈, 嶋田明, 小田慈, 神崎洋光, 永坂岳司

日本小児血液・がん学会雑誌 52 ( 3 ) 340 - 340 2015年10月

胎生期早期の発生が疑われたランゲルハンス組織球症の1例(Suspected early onset of congenital Langerhans cell histiocytosis involving ectopic cervical thymus and mediastinal thymus, simultaneously)

金光喜一郎, 石田悠志, 鷲尾佳奈, 小田慈, 野田卓男, 尾山貴徳, 谷本光隆, 田中健大, 井田健太郎, 嶋田明

日本小児血液・がん学会雑誌 52 ( 4 ) 236 - 236 2015年10月

小児固形腫瘍におけるFDG-PET/CTの有用性の検討(Usefulness of FDG-PET/CT for pediatric solid tumor)

納所洋, 野田卓男, 尾山貴徳, 谷本光隆, 嶋田明, 鷲尾佳奈, 金光喜一郎, 石田悠志

日本小児血液・がん学会雑誌 52 ( 4 ) 336 - 336 2015年10月

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