Research Projects -
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Regulation of the biological character of cancer and induction of cancer by the cancer stroma.
Grant number：18K09789 2018.04 - 2021.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Nakano Keisuke
Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）
The purpose of this study is to verify that the stroma of oral cancer can act on cancer cells to alter their biological properties and that the tumor stroma can act on the normal cells surrounding the cancer to cause tumorigenesis. The effects of the combination of oral squamous cell carcinoma cell lines and stromal cells in culture and tumor stroma on the biological character of tumor cells (proliferative capacity, invasive capacity, migratory capacity, and morphology) were examined histopathologically. The results showed that tumor tissues significantly change their properties depending on differences in tumor stroma. The results of this study strongly support that cancer stroma directly modulates the biological character of cancer.
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Grant number：16K20577 2016.04 - 2020.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
Takabatake Kiyofumi
Grant amount：\4030000 （ Direct expense: \3100000 、 Indirect expense：\930000 ）
The purpose of this study is to develop a new biomaterial that induces both cartilage tissue and bone tissue in thet part of the knee joint defect. Within the study period, a rabbit knee joint defect model was used to induce hard tissue formation by honeycomb TCP. As a result, in the honeycomb TCP having a pore size of 300 μm, bone tissue formation was observed in the bone tissue corresponding part of the knee joint defect and cartilage tissue formation was found in the cartilage corresponding part.
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Characterization and potential roles of bone marrow-derived stromal cells in premetastasis niche
Grant number：16K11441 2016.04 - 2019.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
Nagatsuka Hitoshi
Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）
CD31 is a representative membrane adhesion factor expressed on vascular endothelial cells, but its expression in floating cells in normal tissues has not been reported, and CD31 positive BMDC may be involved in tumor invasion and metastasis It was suggested. Some CD31 positive BMDCs were considered to be involved in premetastatic niche formation.
Moreover, CD11b, Gr-1 double positive BMDC were considered to be immunosuppressive bone marrow-derived cells (Myeloid derived suppressor cells: MDSC), and it was considered that MDSC might be involved in the formation of pre-metastatic niche. -
Grant number：26893158 2014.08 - 2016.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up Grant-in-Aid for Research Activity Start-up
TAKABATAKE Kiyofumi
Grant amount：\2730000 （ Direct expense: \2100000 、 Indirect expense：\630000 ）
In this study, we tried to develop the new biomaterial that induce cartilage and bone tissue seamless at the same time. When we induced cartilage tissue or bone tissue specifically by using different shape honeycomb TCP, honeycomb TCP containing through-hole with 75μm induced cartilage tissue formation. And on the other hand, honeycomb TCP containing through-hole with 300μm induced bone tissue formation.
Therefore we can induce cartilage tissue or bone tissue selectively by changing honeycomb TCP shape, and this finding indicates that the development of new articular cartilage reconstruction method reproduced articular cartilage tissue was suggested when we continue these TCP seamless.