Faculty Profiles - KUNISADA Toshiyuki

Papers - KUNISADA Toshiyuki

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骨・軟部腫瘍切除術時のstaple使用は創合併症に影響しない

国定俊之, 上原健敬, 武田健, 長谷井嬢, 山川泰明, 井上円加, 尾崎敏文

日本整形外科学会雑誌 88 ( 6 ) S1242 - S1242 2014.6

神経線維腫症1型に合併した巨大血腫に対して動脈塞栓術による止血を行った2例

武田健, 篠原健介, 長谷井嬢, 平木隆夫, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 88 ( 6 ) S1252 - S1252 2014.6

骨肉腫におけるribophorin II(RPN2)の機能解析

藤原智洋, 根津悠, 川井章, 武田健, 国定俊之, 尾崎敏文, 落谷孝広

日本整形外科学会雑誌 88 ( 6 ) S1172 - S1172 2014.6

がん治療の個別化における形成外科の役割、期待と現状骨軟部悪性腫瘍の治療診断・切除・再建

尾崎敏文, 国定俊之, 武田健, 藤原智洋, 長谷川健二郎, 木股敬裕

日本癌治療学会誌 49 ( 3 ) 678 - 678 2014.6

A randomized phase II study comparing trabectedin (T) and best supportive care (BSC) in patients (pts) with translocation-related sarcomas (TRS). Reviewed

Shunji Takahashi, Nobuhito Araki, Hideshi Sugiura, Takafumi Ueda, Mitsuru Takahashi, Hideo Morioka, Tsukasa Yonemoto, Hiroaki Hiraga, Toru Hiruma, Toshiyuki Kunisada, Akihiko Matsumine, Akira Kawai

JOURNAL OF CLINICAL ONCOLOGY 32 ( 15 ) 2014.5

Clinical outcomes of Kyocera Modular Limb Salvage system after resection of bone sarcoma of the distal part of the femur: the Japanese Musculoskeletal Oncology Group study Reviewed

Tomoki Nakamura, Akihiko Matsumine, Atsumasa Uchida, Akira Kawai, Yoshihiro Nishida, Toshiyuki Kunisada, Nobuhito Araki, Hideshi Sugiura, Masato Tomita, Masahiro Yokouchi, Takafumi Ueda, Akihiro Sudo

INTERNATIONAL ORTHOPAEDICS 38 ( 4 ) 825 - 830 2014.4

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

The Japanese Musculoskeletal Oncology Group have developed an original prosthesis called the Kyocera Modular Limb Salvage system (KMLS system). This prosthesis has a semi-rotating hinge joint and is particularly designed for people with an Asian body type. The metallic parts of the prosthesis are made entirely of titanium alloy. The purpose of this study is to evaluate the clinical outcomes of treatment using this system following tumour resection of primary bone sarcoma of the distal femur.
Between 2002 and 2010, 82 patients with primary bone sarcomas of the distal femur were treated. Seventeen patients underwent stem cementation, while 65 patients were treated with cementless prostheses. The mean follow-up period after surgery was 61 months.
Complications were observed in 28 of the 82 patients. Forty-one complications occurred in these 28 patients. Thirteen prostheses (16 %) required revision surgery due to complications, including five cases of stem breakage, three deep infections, three cases of aseptic loosening, one case of displacement of the shaft cap and one case of breakage of the tibial tray. The five-year overall prosthetic survival rate was 80.0 %. Four of the 82 patients underwent subsequent amputation due to local recurrence. The five-year limb salvage rate was 94.5 %. The mean function score according to the scoring system of the Musculoskeletal Tumour Society was 21.8 points (72.5 %).
Although further follow-up is required to determine the performance, this prosthesis is considered to be satisfactory for reconstruction of the distal femur after resection of bone sarcoma.

DOI： 10.1007/s00264-013-2151-7

武田健, 国定俊之, 長谷井嬢, 上原健敬, 大森敏規, 尾崎敏文

日本整形外科学会雑誌 88 ( 2 ) S131 - S131 2014.3

Favorable outcome after complete resection in elderly soft tissue sarcoma patients: Japanese Musculoskeletal Oncology Group study Reviewed

Y. Yoneda, T. Kunisada, N. Naka, Y. Nishida, A. Kawai, T. Morii, K. Takeda, J. Hasei, Y. Yamakawa, T. Ozaki

EJSO 40 ( 1 ) 49 - 54 2014.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

Background: The surgical management of soft tissue sarcoma (STS) in elderly patients has only been addressed in a few studies. The objective of the current study was to assess surgical outcomes in patients with STS aged 70 years and older and the association of older age with the survival after complete resection.
Methods: A retrospective analysis was conducted in 158 elderly patients with localized STS who visited 11 institutions participating in Japanese Musculoskeletal Oncology Group between 1995 and 2006 and were treated by surgical resection. Univariate and multivariate analyses were performed to identify prognostic factors.
Results: Median follow-up period was 38 months. Histologically high-grade tumors were detected in 71% of the patients. Wide resection with adequate margins was performed in 66% of the cases. Systemic chemotherapy was performed in only 5 patients. Univariate analysis identified histological grade and gender as statistically significant prognostic factors for sarcoma-specific survival. Multivariate analysis did not identify significant prognostic factors for sarcoma-specific survival, although high grade sarcoma emerged as a potentially significant prognostic factor (P = 0.050). Local recurrence was detected in 19% of the patients. Multivariate analysis of local recurrence-free survival showed that tumor site and surgical margins were statistically significant prognostic factors.
Conclusions: Older age was not identified as a prognostic factor for sarcoma-specific survival, which is not consistent with the findings of previous studies showing that older age was associated with decreased sarcoma-specific survival. Complete resection should be indicated and can lead to optimal treatment outcome for properly selected elderly patients. (C) 2013 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ejso.2013.09.004

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Total Hip Arthroplasty Without Blood Transfusion in a Jehovah's Witness : A Case Report

Tanaka Takaaki, Okada Yoshiki, Ozaki Toshifumi, Fujiwara Kazuo, Endo Hirosuke, Nishida Keiichiro

The Journal of the Chugoku-Shikoku Orthopaedic Association 26 ( 2 ) 255 - 259 2014

Language：Japanese Publisher：The Chugoku-Shikoku Orthopaedic Association

Jehovah's Witnesses refuse blood transfusions on the basis of their religious belief. We report our experience with total hip arthroplasty without blood transfusion in a Jehovah's Witness.<br>The patient was a 70-year-old woman who had been receiving treatment for rheumatoid arthritis for 34 year and had been taking anti-platelet agents for atrial fibrillation and hypertension. Plain radiographs revealed severe erosions (Larsen Grade 4) in the right hip. We used a cemented femoral component and reamed the acetabulum gently to minimize any bleeding, while performing intraoperative blood-salvaging autotransfusion.<br>We carried out hybrid total hip arthroplasty with a cementless acetabular component and a cemented femoral component. The operation time was 62 minutes, intraoperative blood loss was 50ml, and postoperative blood loss was 90ml. The preoperative hemoglobin level was 9.9g/dl, and the lowest hemoglobin level was 6.8g/dl after surgery. At the final follow-up, the patient was able to walk with a T-shaped walking stick, and her Japanese Orthopaedics Association score (right/left) was 80 points/81 points on.<br>We considered that the use of a cemented femoral component and gentle reaming of the acetabulum were factors that reduced bleeding during total hip arthroplasty.

DOI： 10.11360/jcsoa.26.255

CiNii Article

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MicroRNAs in Soft Tissue Sarcomas: Overview of the Accumulating Evidence and Importance as Novel Biomarkers Reviewed

Tomohiro Fujiwara, Toshiyuki Kunisada, Ken Takeda, Koji Uotani, Aki Yoshida, Takahiro Ochiya, Toshifumi Ozaki

BIOMED RESEARCH INTERNATIONAL 2014 592868 2014

Language：English Publisher：HINDAWI PUBLISHING CORPORATION

Sarcomas are distinctly heterogeneous tumors and a variety of subtypes have been described. Although several diagnostic explorations in the past three decades, such as identification of chromosomal translocation, have greatly improved the diagnosis of soft tissue sarcomas, the unsolved issues, including the limited useful biomarkers, remain. Emerging reports on miRNAs in soft tissue sarcomas have provided clues to solving these problems. Evidence of circulating miRNAs in patients with soft tissue sarcomas and healthy individuals has been accumulated and is accelerating their potential to develop into clinical applications. Moreover, miRNAs that function as novel prognostic factors have been identified, thereby facilitating their use in miRNA-targeted therapy. In this review, we provide an overview of the current knowledge on miRNA deregulation in soft tissue sarcomas, and discuss their potential as novel biomarkers and therapeutics.

DOI： 10.1155/2014/592868

Web of Science

PubMed

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Truncated SSX Protein Suppresses Synovial Sarcoma Cell Proliferation by Inhibiting the Localization of SS18-SSX Fusion Protein Reviewed

Yasushi Yoneda, Sachio Ito, Toshiyuki Kunisada, Yuki Morimoto, Hirotaka Kanzaki, Aki Yoshida, Kenji Shimizu, Toshifumi Ozaki, Mamoru Ouchida

PLOS ONE 8 ( 10 ) e77564 2013.10

Language：English Publishing type：Research paper (scientific journal) Publisher：PUBLIC LIBRARY SCIENCE

Synovial sarcoma is a relatively rare high-grade soft tissue sarcoma that often develops in the limbs of young people and induces the lung and the lymph node metastasis resulting in poor prognosis. In patients with synovial sarcoma, specific chromosomal translocation of t(X; 18) (p11.2; q11.2) is observed, and SS18-SSX fusion protein expressed by this translocation is reported to be associated with pathogenesis. However, role of the fusion protein in the pathogenesis of synovial sarcoma has not yet been completely clarified. In this study, we focused on the localization patterns of SS18-SSX fusion protein. We constructed expression plasmids coding for the full length SS18-SSX, the truncated SS18 moiety (tSS18) and the truncated SSX moiety (tSSX) of SS18-SSX, tagged with fluorescent proteins. These plasmids were transfected in synovial sarcoma SYO-1 cells and we observed the expression of these proteins using a fluorescence microscope. The SS18-SSX fusion protein showed a characteristic speckle pattern in the nucleus. However, when SS18-SSX was co-expressed with tSSX, localization of SS18-SSX changed from speckle patterns to the diffused pattern similar to the localization pattern of tSSX and SSX. Furthermore, cell proliferation and colony formation of synovial sarcoma SYO-1 and YaFuSS cells were suppressed by exogenous tSSX expression. Our results suggest that the characteristic speckle localization pattern of SS18-SSX is strongly involved in the tumorigenesis through the SSX moiety of the SS18-SSX fusion protein. These findings could be applied to further understand the pathogenic mechanisms, and towards the development of molecular targeting approach for synovial sarcoma.

DOI： 10.1371/journal.pone.0077564

Web of Science

PubMed

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埋込型中心静脈カテーテルの断裂を来した2例

上原健敬, 武田健, 兒島聡一, 長谷井嬢, 郷原英夫, 国定俊之, 尾崎敏文

中国・四国整形外科学会雑誌 25 ( 3 ) 509 - 509 2013.10

骨線維性異形成の治療成績

武田健, 国定俊之, 上原健敬, 大森敏規, 長谷井嬢, 尾崎敏文

中部日本整形外科災害外科学会雑誌 56 ( 秋季学会 ) 56 - 56 2013.9

脛骨骨幹部骨折に合併した腓骨骨折固定の重要性

山川泰明, 野田知之, 上原健敬, 井上円加, 金澤智子, 中原龍一, 木浪陽, 島村安則, 国定俊之, 尾崎敏文

骨折 35 ( Suppl. ) S350 - S350 2013.6

長期生存が得られた胸椎原発Ewing肉腫の2例

上原健敬, 国定俊之, 武田健, 長谷井嬢, 田中雅人, 尾崎敏文

日本整形外科学会雑誌 87 ( 6 ) S1170 - S1170 2013.6

上腕三頭筋切除を要した軟部肉腫の術後患肢機能

武田健, 国定俊之, 長谷井嬢, 井上円加, 大森敏規, 上原健敬, 山川泰明, 尾崎修平, 吉田晶, 尾崎敏文

日本整形外科学会雑誌 87 ( 6 ) S1190 - S1190 2013.6

Oncolytic adenovirus-armed p53 induces apoptosis significantly through upregulating miR-93 and 106b in human osteosarcoma cells

Joe Hasei, Tsuyoshi Sasaki, Hiroshi Tazawa, Yuuri Hashimoto, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara

CANCER RESEARCH 73 ( 8 ) 2013.4

Management of Lumbar Artery Injury Related to Pedicle Screw Insertion Reviewed

Yoshihisa Sugimoto, Masato Tanaka, Hideo Gobara, Haruo Misawa, Toshiyuki Kunisada, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 67 ( 2 ) 113 - 116 2013.4

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

We report on 2 patients who experienced injury to one of their lumbar arteries related to pedicle screw misplacement. In this report, the lumbar pedicle screw holes were made laterally with resultant injury to the lumbar artery. During surgery, arterial bleeding was controlled with pressure and gauze; however, the patients experienced vital shock after surgery. Vital shock ensued and they were rescued by catheter embolization. If patients receiving lumbar instrumentation surgery experience severe anemia or vital shock postoperatively, the surgeon should assume lumbar artery injury as a differential diagnosis.

DOI： 10.18926/AMO/49670

武田健, 上原健敬, 大森敏規, 原田遼三, 長谷井嬢, 吉田晶, 尾崎敏文, 国定俊之

中国・四国整形外科学会雑誌 25 ( 1 ) 239 - 239 2013.4

Combined effect of zoledronic acid and telomerase-specific oncolytic virotherapy for human osteosarcoma cells.

Yasuaki Yamakawa, Joe Hasei, Hiroshi Tazawa, Shuhei Osaki, Tsuyoshi Sasaki, Toshiyuki Kunisada, Aki Yoshida, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara

CANCER RESEARCH 73 ( 8 ) 2013.4

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