研究者詳細 - 國定　俊之

論文 - 國定　俊之

分割表示 556 件中 361 - 380 件目／全件表示 >>

腫瘍特異的増殖型ウイルスによる骨・軟部肉腫circulating tumor cell(CTC)検出法の検討

小松原将, 山川泰明, 大森敏規, 杉生和久, 魚谷弘二, 吉田晶, 藤原智洋, 武田健, 国定俊之, 浦田泰生, 尾崎敏文

日本整形外科学会雑誌 89 ( 8 ) S1795 - S1795 2015年9月

骨・軟部肉腫に対する腫瘍融解アデノウイルスと放射線療法の併用効果

大森敏規, 山川泰明, 長谷井嬢, 田澤大, 尾崎修平, 杉生和久, 藤原智洋, 国定俊之, 浦田泰生, 藤原俊義, 尾崎敏文

日本整形外科学会雑誌 89 ( 8 ) S1673 - S1673 2015年9月

腫瘍融解アデノウイルスの骨・軟部腫瘍臨床組織検体に対する感染効率および適応症例の検討

吉田晶, 藤原智洋, 魚谷弘二, 長谷井嬢, 山川泰明, 大森敏規, 杉生和久, 武田健, 国定俊之, 藤原俊義, 尾崎敏文

日本整形外科学会雑誌 89 ( 8 ) S1673 - S1673 2015年9月

指神経に発生した巨指症を伴わないFibrolipomatous hamartomaの1例

清野正普, 武田健, 藤原智洋, 国定俊之, 尾崎敏文

中部日本整形外科災害外科学会雑誌 58 ( 秋季学会 ) 283 - 283 2015年9月

滑膜肉腫患者血清から特定した滑膜肉腫特異的分泌型miRNAに関する検討

魚谷弘二, 藤原智洋, 吉田晶, 山川泰明, 大森敏規, 杉生和久, 武田健, 国定俊之, 根津悠, 川井章, 尾崎敏文

日本整形外科学会雑誌 89 ( 8 ) S1478 - S1478 2015年9月

骨盤発生の放射線照射後肉腫の治療成績

武田健, 国定俊之, 藤原智洋, 魚谷弘二, 杉生和久, 尾崎敏文

中部日本整形外科災害外科学会雑誌 58 ( 秋季学会 ) 286 - 286 2015年9月

骨肉腫に対するテロメラーゼ依存性腫瘍融解アデノウイルスと骨周囲環境制御による新規治療戦略

山川泰明, 長谷井嬢, 田澤大, 杉生和久, 魚谷弘二, 大森敏規, 尾崎修平, 吉田晶, 藤原智洋, 武田健, 国定俊之, 浦田泰生, 藤原俊義, 尾崎敏文

日本整形外科学会雑誌 89 ( 8 ) S1798 - S1798 2015年9月

Liquid biopsyに応用可能なEwing肉腫細胞由来のexosome表面マーカーの同定

森田卓也, 藤原智洋, 魚谷弘二, 吉田晶, 山川泰明, 大森敏規, 杉生和久, 武田健, 国定俊之, 吉岡祐亮, 植田幸嗣, 尾崎敏文

日本整形外科学会雑誌 89 ( 8 ) S1796 - S1796 2015年9月

骨軟部骨軟部腫瘍治療の新たな展開仙骨脊索腫治療後の再発切除術と重粒子線治療

国定俊之, 武田健, 藤原智洋, 鎌田正, 今井礼子, 不破信和, 尾崎敏文

日本癌治療学会誌 50 ( 3 ) 2021 - 2021 2015年9月

骨肉腫に対する化学療法とp53発現腫瘍融解アデノウイルス治療の併用効果

杉生和久, 小松原将, 大森敏規, 山川泰明, 吉田晶, 藤原智洋, 武田健, 国定俊之, 田澤大, 藤原俊義, 尾崎敏文

日本整形外科学会雑誌 89 ( 8 ) S1799 - S1799 2015年9月

骨・軟部肉腫のゲノム解析と新治療開発の展望骨軟部腫瘍に対する手術療法の進歩

尾崎敏文, 国定俊之, 武田健, 藤原智洋

日本癌治療学会誌 50 ( 3 ) 2115 - 2115 2015年9月

Preclinical evaluation of radiotherapy in combination with radio-sensitizing telomerase-specific oncolytic virus for human bone and soft tissue sarcomas

Toshinori Omori, Yasuaki Yamakawa, Joe Hasei, Hiroshi Tazawa, Shuhei Osaki, Tusyoshi Sasaki, Kazuhisa Sugiu, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara

CANCER RESEARCH 75 2015年8月

Both a visual and a semiquantitative analysis for differentiating benign from malignant chondrogenic bone tumors using Tc-99m (V) DMSA scintigraphy: a prospective study 査読

Takayoshi Shinya, Shuhei Sato, Toshiyuki Kunisada, Ryota Inai, Hiroyuki Yanai, Toshifumi Ozaki, Susumu Kanazawa

NUCLEAR MEDICINE COMMUNICATIONS 36 ( 8 ) 802 - 807 2015年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

ObjectiveThe aims of this prospective study were to assess the relationship between tumor aggressiveness and Tc-99m (V) dimercaptosuccinic acid (DMSA) uptake in chondrogenic bone tumors and the value of Tc-99m (V) DMSA scintigraphy for differentiating benign from malignant tumors.MethodsTwenty-four patients with chondrogenic tumors (19 benign and five malignant) underwent Tc-99m DMSA (V) scintigraphy. Radiopharmaceutical uptake was classified using a three-point scale to allow a visual-only analysis, and a tumor-to-background contrast (TBC) was computed using regions of interest to provide a semiquantitative analysis. Spearman's correlation coefficient was used to assess the correlation between tumor aggressiveness and TBC. The difference in TBC between benign and malignant tumors was analyzed with the Mann-Whitney U-test. An appropriate cutoff value of TBC was chosen for the diagnosis of malignancy of a tumor using receiver operating characteristic analysis.ResultsSix benign tumors showed negative uptake (uptake score 0), whereas 13 benign tumors showed positive uptake (n=10 uptake score 1; n=3 uptake score 2). All chondrosarcomas showed positive uptake (n=2 uptake score 1; n=3 uptake score 2). A significant correlation was found between tumor aggressiveness and TBC. A significant difference was seen in TBC between benign and malignant tumors. With the chosen cutoff value of TBC equal to 0.611, the sensitivity was 80.0%, specificity was 78.9%, the positive predictive value was 50.0%, and the negative predictive value was 93.8%.ConclusionTc-99m (V) DMSA scintigraphy may have the potential to improve diagnostic methods for detecting chondrosarcomas using visual and/or semiquantitative analyses.

DOI： 10.1097/MNM.0000000000000328

Web of Science

PubMed

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Venous Thromboembolism after Total Hip Arthroplasty Diagnosed by Enhanced Computed Tomography: Comparison of Selective Thromboprophylaxis and No Thromboprophylaxis 査読

Yoshiki Okada, Hirosuke Endo, Shigeru Mitani, Kazuo Fujiwara, Tomonori Tetsunaga, Yohei Kagawa, Yosuke Fujii, Toshiyuki Kunisada, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 69 ( 4 ) 205 - 212 2015年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Total hip arthroplasty (THA) is the most effective treatment for advanced or end-stage hip osteoarthritis. However, venous thromboembolism (VTE) remains one of its unresolved complications. We reviewed the records of 322 patients undergoing primary THA and investigated the efficacy of anticoagulant prophylaxis for VTE. Our study cohort consisted of 60 patients who received no anticoagulants, 100 patients who received a factor Xa inhibitor (fondaparinux), 100 patients who received low molecular weight heparin (enoxaparin), and 62 patients who selectively received no anticoagulant prophylaxis due to perioperative bleeding, weight, and/or hemoglobin concentration. Enhanced 64-slice multidetector row computed tomography was performed postoperatively for 7 days in all cases. The incidence of VTE in the four groups was 15%, 9.0%, 6.0%, and 6.4%, respectively. The incidence of VTE was significantly lower in the groups receiving anticoagulant prophylaxis and the group selectively receiving no anticoagulant prophylaxis than in the group receiving no anticoagulants. Complications of fondaparinux therapy included hepatic dysfunction in 4 cases (4.0%), minor bleeding in 2 cases (2.0%), persistent wound drainage in 3 cases (3.0%), and eruption in 1 case (1.0%). The complications of enoxaparin therapy were persistent wound drainage in 1 case (1.0%) and progression of anemia in 1 case (1.0%). The incidence of VTE was low in patients who selectively received no anticoagulant prophylaxis, so we conclude that anticoagulant prophylaxis should be used selectively in THA cases.

DOI： 10.18926/AMO/53556

藤原智洋, 国定俊之, 武田健, 山川泰明, 大森敏規, 上原健敬, 魚谷弘二, 杉生和久, 尾崎敏文

日本整形外科学会雑誌 89 ( 6 ) S1308 - S1308 2015年6月