研究者詳細 - 國定　俊之

論文 - 國定　俊之

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骨肉腫X線画像の読影を目指した人工知能の開発

長谷井嬢, 中田英二, 国定俊之, 尾崎敏文

日本CAOS研究会・日本最小侵襲整形外科学会プログラム・抄録集 14回・26回 135 - 135 2020年3月

Molecular radiosensitization of soft tissue sarcoma by oncolytic virus-mediated MCL1 ablation

Omori T, Tazawa H, Yamakawa Y, Osaki S, Hasei J, Sugiu K, Komatsubara T, Fujiwara T, Yoshida A, Kunisada T, Urata Y, Kagawa S, Ozaki T, Fujiwara T

2020年1月

Standard Treatment Remains the Recommended Approach for Patients with Bone Sarcoma Who Underwent Unplanned Surgery: Report from the Japanese Musculoskeletal Oncology Group. 査読国際誌

Tomoki Nakamura, Jun Sugaya, Norifumi Naka, Hiroshi Kobayashi, Tomotake Okuma, Toshiyuki Kunisada, Kunihiro Asanuma, Hedetatsu Outani, Shunji Nishimura, Hiroyuki Kawashima, Toru Akiyama, Taketoshi Yasuda, Shinji Miwa, Akihiro Sudo, Takafumi Ueda

Cancer management and research 12 10017 - 10022 2020年

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: The outcomes of unplanned surgery for bone sarcomas have not been frequently discussed. However, it is important to recognize patterns, treatment, and clinical outcomes of unplanned surgeries for patients with bone sarcomas. This multicenter study aimed to characterize the clinical outcomes of patients with bone sarcomas who underwent unplanned surgeries. Patients and Methods: Data of 43 patients with bone sarcomas who underwent unplanned surgery between 2006 and 2017 were obtained from 23 hospitals in Japan. These included 18 cases of osteosarcoma, 9 of Ewing sarcoma, 8 of chondrosarcoma, and 6 of undifferentiated pleomorphic sarcoma. The study included 28 men and 15 women, with a mean age of 46 years. The mean follow-up duration was 59 months. Results: The main primary tumor sites were the femur (n = 19), spine (n = 6), pelvis (n = 5), tibia (n = 3), and humerus (n = 3). The primary diagnoses were benign bone tumor (n = 24), trauma (n = 7), bone metastasis (n = 5), osteomyelitis (n = 4), degeneration (n=2), and unknown (n = 1). As unplanned surgeries, curettage, with or without bone graft, was performed in 26 patients; internal fixation was performed in 7; spinal surgery in 5; arthroplasty in 4; and arthroscopy in one. Thirty-eight patients received additional standard treatments. Thirty-four of these patients underwent surgical tumor resections, including amputation (n = 10), and the remaining 4 received radiotherapy or carbon ion radiotherapy as additional standard treatments. The 5-year disease-specific survival (DSS) rates in patients with osteosarcoma, Ewing sarcoma, and chondrosarcoma were 65.5%, 58.3%, and 72.9%, respectively. Twelve (27.9%) patients developed local recurrences (LR); among the total 43 patients studied, the 5-year DSS rates were significantly worse for those who developed LR compared to those who did not (p = 0.03). The 5-year DSS rates in patients with and without LR were 44% and 73.8%, respectively. Conclusion: We recommend that patients who have undergone unplanned surgery be administered standard treatment, including the option of amputation because herein, LR was shown to be a risk factor for decreased DSS.

DOI： 10.2147/CMAR.S270178

PubMed

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【スポーツ診療における画像診断-医療安全上必要なコツと落とし穴-】スポーツ外傷・障害と間違えやすい病変

尾崎敏文, 中田英二, 長谷井嬢, 国定俊之

関節外科 38 ( 11 ) 1142 - 1150 2019年11月

記述言語：日本語出版者・発行元：(株)メジカルビュー社

スポーツを活発に行う年齢層が骨・軟部腫瘍の好発年齢と一致しているため,スポーツ外傷や障害と骨・軟部腫瘍との鑑別診断は重要である。それらの病変のなかには,(1)偶然発見されたX線像に写った無症候性の病変,(2)疼痛などの症状を伴い骨腫瘍疑いと紹介されてきたが骨腫瘍ではなかった病変,そして(3)骨腫瘍疑いで紹介されてきて真の治療を要する骨腫瘍であった症例などがある。スポーツ外傷・障害を診断するうえで骨腫瘍の知識は重要であるが,それに加えて,外傷,骨折,炎症性疾患など整形外科疾患全般の基本知識も重要である。(著者抄録)

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00282&link_issn=&doc_id=20191025090004&doc_link_id=10.18885%2FJ00282.2020041696&url=https%3A%2F%2Fdoi.org%2F10.18885%2FJ00282.2020041696&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

顆粒細胞腫における液胞型ATPアーゼ複合体の高頻度変異の同定

関水壮哉, 吉田朗彦, 三谷幸代, 浅野尚文, 平田真, 久保崇, 平賀博明, 米本司, 河本旭哉, 中紀文, 船内雄生, 西田佳弘, 朴木寛弥, 河野博隆, 土屋弘行, 国定俊之, 松田浩一, 稲垣克記, 川井章, 市川仁

日本整形外科学会雑誌 93 ( 6 ) S1425 - S1425 2019年6月

Frequent mutations of genes encoding vacuolar H+ -ATPase components in granular cell tumors. 査読国際誌

Masaya Sekimizu, Akihiko Yoshida, Sachiyo Mitani, Naofumi Asano, Makoto Hirata, Takashi Kubo, Fumito Yamazaki, Hiromi Sakamoto, Mamoru Kato, Naohiro Makise, Taisuke Mori, Naoya Yamazaki, Shigeki Sekine, Ichiro Oda, Shun-Ichi Watanabe, Hiroaki Hiraga, Tsukasa Yonemoto, Teruya Kawamoto, Norifumi Naka, Yuki Funauchi, Yoshihiro Nishida, Kanya Honoki, Hirotaka Kawano, Hiroyuki Tsuchiya, Toshiyuki Kunisada, Koichi Matsuda, Katsunori Inagaki, Akira Kawai, Hitoshi Ichikawa

Genes, chromosomes & cancer 58 ( 6 ) 373 - 380 2019年6月

記述言語：英語

Granular cell tumors (GCTs) are rare mesenchymal tumors that exhibit a characteristic morphology and a finely granular cytoplasm. The genetic alterations responsible for GCT tumorigenesis had been unknown until recently, when loss-of-function mutations of ATP6AP1 and ATP6AP2 were described. Thus, we performed whole-exome sequencing, RNA sequencing, and targeted sequencing of 51 GCT samples. From these genomic analyses, we identified mutations in genes encoding vacuolar H+ -ATPase (V-ATPase) components, including ATP6AP1 and ATP6AP2, in 33 (65%) GCTs. ATP6AP1 and ATP6AP2 mutations were found in 23 (45%) and 2 (4%) samples, respectively, and all were truncating or splice site mutations. In addition, seven other genes encoding V-ATPase components were also mutated, and three mutations in ATP6V0C occurred on the same amino acid (isoleucine 136). These V-ATPase component gene mutations were mutually exclusive, with one exception. These results suggest that V-ATPase function is impaired in GCTs not only by loss-of-function mutations of ATP6AP1 and ATP6AP2 but also through mutations of other subunits. Our findings provide additional support for the hypothesis that V-ATPase dysfunction promotes GCT tumorigenesis.

DOI： 10.1002/gcc.22727

PubMed

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悪性骨盤腫瘍患者に対する患肢温存術後のADLとQOLについて術後9年後のインタビューより

岡佳純, 妹尾勝利, 堅山佳美, 国定俊之, 千田益生

The Japanese Journal of Rehabilitation Medicine 56 ( 特別号 ) 3 - 4 2019年5月

Temporary External Fixation Can Stabilize Hip Transposition Arthroplasty After Resection of Malignant Periacetabular Bone Tumors. 査読国際誌

Kunisada T, Fujiwara T, Hasei J, Nakata E, Senda M, Ozaki T

Clinical orthopaedics and related research 477 ( 8 ) 1892 - 1901 2019年4月

Mini-open excision of osteoid osteoma using intraoperative O-arm/Stealth navigation. 査読

Fujiwara T, Kunisada T, Takeda K, Hasei J, Nakata E, Mochizuki Y, Kiyono M, Yoshida A, Ozaki T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 24 ( 2 ) 337 - 341 2019年3月

Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects. 査読国際誌

Uehara T, Eikawa S, Nishida M, Kunisada Y, Yoshida A, Fujiwara T, Kunisada T, Ozaki T, Udono H

International immunology 31 ( 4 ) 187 - 198 2019年3月

Randomized placebo-controlled double-blind phase II study of zaltoprofen for patients with diffuse-type and unresectable localized tenosynovial giant cell tumors: a study protocol. 査読

Takeuchi A, Nomura A, Yamamoto N, Hayashi K, Igarashi K, Tandai S, Kawai A, Matsumine A, Miwa S, Nishida Y, Nakamura T, Terauchi R, Hoshi M, Kunisada T, Endo M, Yoshimura K, Murayama T, Tsuchiya H

BMC musculoskeletal disorders 20 ( 1 ) 68 2019年2月

Sub-deltoid approach for removal of large lipoma around the proximal humerus: A report of three cases. 査読

Hasei J, Kunisada T, Nakata E, Ozaki T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 26 ( 6 ) 1147 - 1151 2019年2月

Regeneration of the Fibula with Unidirectional Porous Hydroxyapatite. 国際誌

Koji Demiya, Toshiyuki Kunisada, Eiji Nakata, Joe Hasei, Toshifumi Ozaki

Case reports in orthopedics 2019 9024643 - 9024643 2019年

記述言語：英語

A fibula graft is one of the most common orthopedic procedures for reconstruction of a bone defect, and some complications related to persistent defects of the fibula have been reported previously. We believe that regeneration of the fibula may be critical for postoperative function and prevention of complications. This report describes a 9-year-old female with Ewing sarcoma of the pelvis who was treated with the double-barrel fibula grafts for pelvic bone defect following tumor resection. The defect after fibular resection was filled with unidirectional porous hydroxyapatite (UDPHAp) implants. A plain radiograph revealed new bone formation and a callus-like structure at one month after surgery and bony union between each UDPHAp implant 5 months after surgery. Resorption of implanted UDPHAp was identified, and partial remodeling of the bone marrow cavity could be seen 1 year 2 months after surgery. A radiograph at final follow-up (5 years 10 months after surgery) demonstrated almost complete absorption of the implanted UDPHAp and clear formation of the cortex and bone marrow in the resected part of the fibula. The patient is able to walk well without any walking supports and to take part in sports activities.

DOI： 10.1155/2019/9024643

PubMed

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Clinical features and treatment outcome of desmoid-type fibromatosis: based on a bone and soft tissue tumor registry in Japan 査読

Nishida Y, Kawai A, Toguchida J, Ogose A, Ae K, Kunisada T, Matsumoto Y, Matsunobu T, Takahashi K, Nishida K, Ozaki T

International Journal of Clinical Oncology 24 1498 - 1505 2019年

Identification of Circulating Exosomal Marker in Synovial Sarcoma

Suguru Yokoo, Tomohiro Fujiwara, Aki Yoshida, Masahiro Kiyono, Yusuke Mochizuki, Koji Demiya, Joe Hasei, Toshiyuki Kunisada, Yusuke Yoshioka, Koji Ueda, Takahiro Ochiya, Toshifumi Ozaki

CANCER SCIENCE 109 570 - 570 2018年12月

Injury patterns of medial meniscus posterior root tears. 査読国際誌

Furumatsu T, Okazaki Y, Okazaki Y, Hino T, Kamatsuki Y, Masuda S, Miyazawa S, Nakata E, Hasei J, Kunisada T, Ozaki T

Orthopaedics & traumatology, surgery & research : OTSR 105 ( 1 ) 107 - 111 2018年11月

Intraoperative O-arm-navigated resection in musculoskeletal tumors. 査読

Fujiwara T, Kunisada T, Takeda K, Hasei J, Nakata E, Nakahara R, Yoshida A, Ozaki T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 23 ( 6 ) 1045 - 1050 2018年11月

Is immunohistochemical staining for β-catenin the definitive pathological diagnostic tool for desmoid-type fibromatosis?: a multi-institutional study. 査読国際誌

Koike H, Nishida Y, Kohno K, Shimoyama Y, Motoi T, Hamada S, Kawai A, Ogose A, Ozaki T, Kunisada T, Matsumoto Y, Matsunobu T, Ae K, Gokita T, Sakai T, Shimizu K, Ishiguro N

Human pathology 84 155 - 163 2018年10月

Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study. 査読国際誌

Urakawa H, Yonemoto T, Matsumoto S, Takagi T, Asanuma K, Watanuki M, Takemoto A, Naka N, Matsumoto Y, Kawai A, Kunisada T, Kubo T, Emori M, Hiraga H, Hatano H, Tsukushi S, Nishida Y, Akisue T, Morii T, Takahashi M, Nagano A, Yoshikawa H, Sato K, Kawano M, Hiraoka K, Tanaka K, Iwamoto Y, Ozaki T

World journal of surgical oncology 16 ( 1 ) 160 - 160 2018年8月

骨・軟部腫瘍における新規分子・細胞標的粘液線維肉腫における分泌型microRNA-1260bは腫瘍周囲微小環境に作用し浸潤を促進する

森田卓也, 藤原智洋, 吉田晶, 清野正普, 横尾賢, 小松原将, 望月雄介, 長谷井嬢, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 92 ( 8 ) S1709 - S1709 2018年8月

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