2024/12/19 更新

写真a

ゾウ　ヤジュアン
ZOU YAJUAN
ZOU YAJUAN
所属
異分野基礎科学研究所 助教（特任）
職名
助教（特任）
外部リンク

学位

  • 博士（人間・環境学） （ 2021 京都大学 ）

研究キーワード

  • nanoparticle; surface functionalization; nano-bio interaction; drug delivery; quantum sensing; nanothermometer; photonics

研究分野

  • ナノテク・材料 / ナノバイオサイエンス

  • ナノテク・材料 / ナノ構造化学

学歴

  • 京都大学 大学院人間・環境学研究科 相関環境学専攻    

    2018年 - 2021年

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  • 上海交通大学 生命科学研究科 生物化学・分子生物学専攻    

    2004年 - 2007年

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  • 天津大学 化学工学院 化学工学科    

    2000年 - 2004年

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経歴

  • 岡山大学   助教 (特任)

    2021年 - 現在

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  • 上海交通大学   エンジニア

    2010年 - 2017年

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  • 上海交通大学   アシスタントエンジニア

    2007年 - 2010年

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所属学協会

 

論文

  • Size, polyglycerol grafting, and net surface charge of iron oxide nanoparticles determine their interaction and toxicity in Caenorhabditis elegans. 国際誌

    Yajuan Zou, Yutaka Shikano, Yuta Nishina, Naoki Komatsu, Eriko Kage-Nakadai, Masazumi Fujiwara

    Chemosphere   142060 - 142060   2024年4月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The widespread application of engineered nanoparticles (NPs) in environmental remediation has raised public concerns about their toxicity to aquatic organisms. Although appropriate surface modification can mitigate the ecotoxicity of NPs, the lack of polymer coating to inhibit toxicity completely and the insufficient knowledge about charge effect hinder the development of safe nanomaterials. Herein, we explored the potential of polyglycerol (PG) functionalization in alleviating the environmental risks of NPs. Iron oxide NPs (ION) of 20, 100, and 200 nm sizes (IONS, IONM and IONL, respectively) were grafted with PG to afford ION-PG. We examined the interaction of ION and ION-PG with Caenorhabditis elegans (C. elegans) and found that PG suppressed non-specific interaction of ION with C. elegans to reduce their accumulation and to inhibit their translocation. Particularly, IONS-PG was completely excluded from worms of all developmental stages. By covalently introducing sulfate, carboxyl and amino groups onto IONS-PG, we further demonstrated that positively charged IONS-PG-NH3+ induced high intestinal accumulation, cuticle adhesion and distal translocation, whereas the negatively charged IONS-PG-OSO3- and IONS-PG-COO- were excreted out. Consequently, no apparent deleterious effects on brood size and life span were observed in worms treated by IONS-PG and IONS-PG bearing negatively charged groups. This study presents new surface functionalization approaches for developing ecofriendly nanomaterials.

    DOI： 10.1016/j.chemosphere.2024.142060

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  • The use of covalent reactions to improve the biomedical applications of carbon nanomaterials 招待 査読

    Yajuan Zou, Yuta Nishina, Alberto Bianco

    Carbon Reports   2 ( 4 )   185 - 198   2023年12月

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    担当区分：筆頭著者,　責任著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Carbon Society of Japan  

    DOI： 10.7209/carbon.020405

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  • Polyglycerol Functionalized B-10 Enriched Boron Carbide Nanoparticle as an Effective Bimodal Anticancer Nanosensitizer for Boron Neutron Capture and Photothermal Therapies 国際誌

    Yuquan Wang, Giacomo Reina, Heon Gyu Kang, Xiaoxiao Chen, Yajuan Zou, Yoshie Ishikawa, Minoru Suzuki, Naoki Komatsu

    Small   18 ( 37 )   2204044 - 2204044   2022年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

    Boron neutron capture therapy (BNCT) is a non-invasive cancer treatment with little adverse effect utilizing nuclear fission of 10 B upon neutron irradiation. While neutron source has been developed from a nuclear reactor to a compact accelerator, only two kinds of drugs, boronophenylalanine and sodium borocaptate, have been clinically used for decades despite their low tumor specificity and/or retentivity. To overcome these challenges, various boron-containing nanomaterials, or "nanosensitizers", have been designed based on micelles, (bio)polymers and inorganic nanoparticles. Among them, inorganic nanoparticles such as boron carbide can include a much higher 10 B content, but successful in vivo applications are very limited. Additionally, recent reports on the photothermal effect of boron carbide are motivating for the addition of another modality of photothermal therapy. In this study, 10 B enriched boron carbide (10 B4 C) nanoparticle is functionalized with polyglycerol (PG), giving 10 B4 C-PG with enough dispersibility in a physiological environment. Pharmacokinetic experiments show that 10 B4 C-PG fulfills the following three requirements for BNCT; 1) low intrinsic toxicity, 2) 10 B in tumor/tumor tissue (wt/wt) ≥ 20 ppm, and 3) 10 B concentrations in tumor/blood ≥ 3. In vivo study reveals that neutron irradiation after intravenous administration of 10 B4 C-PG suppresses cancer growth significantly and eradicates cancer with the help of near-infrared light irradiation.

    DOI： 10.1002/smll.202204044

    PubMed

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    その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/smll.202204044

  • Organic chemistry for nanodiamond: Controlled functionalization, quantitative characterization and structure-property relationships 招待 査読

    Yajuan Zou, Masahiro Nishikawa, Naoki Komatsu

    Carbon Reports   1 ( 2 )   70 - 78   2022年6月

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    担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Carbon Society of Japan  

    DOI： 10.7209/carbon.010204

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  • Probing the Role of Charged Functional Groups on Nanoparticles Grafted with Polyglycerol in Protein Adsorption and Cellular Uptake 査読

    Yajuan Zou, Shinji Ito, Masazumi Fujiwara, Naoki Komatsu

    Advanced Functional Materials   2111077 - 2111077   2022年1月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/adfm.202111077

    Web of Science

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    その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/adfm.202111077

  • Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples

    Keisuke Oshimi, Yushi Nishimura, Tsutomu Matsubara, Masuaki Tanaka, Eiji Shikoh, Li Zhao, Yajuan Zou, Naoki Komatsu, Yuta Ikado, Yuka Takezawa, Eriko Kage-Nakadai, Yumi Izutsu, Katsutoshi Yoshizato, Saho Morita, Masato Tokunaga, Hiroshi Yukawa, Yoshinobu Baba, Yoshio Teki, Masazumi Fujiwara

    Lab on a Chip   22 ( 13 )   2519 - 2530   2022年

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Royal Society of Chemistry (RSC)  

    This on-chip device realizes large-area and predictable spin detection of fluorescent nanodiamonds, providing a scalable platform for quantum-sensor-based bioassay.

    DOI： 10.1039/d2lc00112h

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  • Conjugation of Phenylboronic Acid Moiety through Multistep Organic Transformations on Nanodiamond Surface for an Anticancer Nanodrug for Boron Neutron Capture Therapy 査読

    Masahiro Nishikawa, Heon Gyu Kang, Yajuan Zou, Hidekazu Takeuchi, Naoyoshi Matsuno, Minoru Suzuki, Naoki Komatsu

    Bulletin of the Chemical Society of Japan   94 ( 9 )   2302 - 2312   2021年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Chemical Society of Japan  

    DOI： 10.1246/bcsj.20210200

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  • Effect of Protein Corona on Mitochondrial Targeting Ability and Cytotoxicity of Triphenylphosphonium Conjugated with Polyglycerol-Functionalized Nanodiamond 査読

    Yajuan Zou, Masahiro Nishikawa, Heon Gyu Kang, Guoqing Cheng, Wei Wang, Yuquan Wang, Naoki Komatsu

    Molecular Pharmaceutics   18 ( 7 )   2823 - 2832   2021年7月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Chemical Society (ACS)  

    DOI： 10.1021/acs.molpharmaceut.1c00188

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  • Hydrophobic Surface Coating of Nanodiamonds by Polyglycerol‐Based Polymers with Alkyl Chains for Dispersing in an Organic Solvent 査読

    Wei Wang, Yajuan Zou, Alejandro López‐Moreno, Yujing Jiang, Feng Wen, Hong‐Xing Wang, Naoki Komatsu

    ChemNanoMat   6 ( 9 )   1332 - 1336   2020年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

    DOI： 10.1002/cnma.202000271

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    その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cnma.202000271

  • Quantitative investigation of the interaction between proteins and charged functional groups on the polyglycerol-grafted nanodiamond surface 査読

    Yajuan Zou, Naoki Komatsu

    Carbon   163   395 - 401   2020年8月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.carbon.2020.02.089

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  • Polyglycerol Grafting Shields Nanoparticles from Protein Corona Formation to Avoid Macrophage Uptake 査読 国際誌

    Yajuan Zou, Shinji Ito, Fumi Yoshino, Yuta Suzuki, Li Zhao, Naoki Komatsu

    ACS Nano   14 ( 6 )   7216 - 7226   2020年6月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Chemical Society (ACS)  

    Upon contact with biofluids, proteins are quickly adsorbed onto the nanoparticle (NP) surface to form a protein corona, which initiates the opsonization and facilitates the rapid clearance of the NP by macrophage uptake. Although polyethylene glycol (PEG) functionalization has been the standard approach to evade macrophage uptake by reducing protein adsorption, it cannot fully eliminate nonspecific uptake. Herein, polyglycerol (PG) grafting is demonstrated as a better alternative to PEG. NPs of various size and material were grafted with PG and PEG at 30, 20, and 10 wt % contents by controlling the reaction conditions, and the resulting NP-PG and NP-PEG were characterized qualitatively by IR spectroscopy and quantitatively by thermogravimetric analysis. Their resistivity to adsorption of the proteins in fetal bovine serum and human plasma were compared by polyacrylamide gel electrophoresis, bicinchoninic acid assay, and liquid chromatography-tandem mass spectrometry, giving a consistent conclusion that PG shields protein adsorption more efficiently than does PEG. The macrophage uptake was assayed by transmission electron microscopy and by extinction spectroscopy or inductively coupled plasma mass spectrometry, revealing that PG avoids macrophage uptake more efficiently than does PEG. In particular, a NP coated with PG at 30 wt % (NP-PG-h) prevents corona formation almost completely, regardless of NP size and core material, leading to the complete evasion of macrophage uptake. Our findings demonstrate that PG grafting is a promising strategy in nanomedicine to improve anti-biofouling property and stealth efficiency in nanoformulations.

    DOI： 10.1021/acsnano.0c02289

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  • Preferential Tumor Accumulation of Polyglycerol Functionalized Nanodiamond Conjugated with Cyanine Dye Leading to Near‐Infrared Fluorescence In Vivo Tumor Imaging 査読

    Fumi Yoshino, Tsukuru Amano, Yajuan Zou, Jian Xu, Fuminori Kimura, Yoshio Furusho, Tokuhiro Chano, Takashi Murakami, Li Zhao, Naoki Komatsu

    Small   15 ( 48 )   1901930 - 1901930   2019年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

    Preferential accumulation of nanoparticles in a tumor is realized commonly by combined effects of active and passive targeting. However, passive targeting based on an enhanced permeation and retention (EPR) effect is not sufficient to observe clear tumor fluorescence images in most of the in vivo experiments using tumor-bearing mice. Herein, polyglycerol-functionalized nanodiamonds (ND-PG) conjugated with cyanine dye (Cy7) are synthesized and it is found that the resulting ND-PG-Cy7 is preferentially accumulated in the tumor, giving clear fluorescence in in vivo and ex vivo fluorescence images. One of the plausible reasons is the longer in vivo blood circulation time of ND-PG-Cy7 (half-life: 58 h determined by the pharmacokinetic analysis) than that of other nanoparticles (half-life: <20 h in most of the previous reports). In a typical example, the fluorescence intensity of tumors increases due to continuous tumor accumulation of ND-PG-Cy7, even more than one week postinjection. This may be owing to the stealth effect of PG that was reported previously, avoiding recognition and excretion by reticuloendothelial cells, which are abundant in liver and spleen. In fact, the fluorescence intensities from the liver and spleen is similar to those from other organs, while the tumor exhibits much stronger fluorescence in the ex vivo image.

    DOI： 10.1002/smll.201901930

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    その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/smll.201901930

  • Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property 査読

    Gang Liu, Ping Zhao, Neng Liu, Fumi Yoshino, Hongmei Qin, Yajuan Zou, Shengwei Shi, Tsukuru Amano, Jose R Aguilar Cosme, Yasunobu Nagano, Hitoshi Tamiaki, Naoki Komatsu

    2D Materials   6 ( 4 )   045035 - 045035   2019年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：IOP Publishing  

    Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2-Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

    DOI： 10.1088/2053-1583/ab377b

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    その他リンク： https://iopscience.iop.org/article/10.1088/2053-1583/ab377b/pdf

  • VCAM-1-mediated neutrophil infiltration exacerbates ambient fine particle-induced lung injury 査読

    Anfeng Cui, Meng Xiang, Ming Xu, Peng Lu, Shun Wang, Yajuan Zou, Ke Qiao, Chengyu Jin, Yijun Li, Meng Lu, Alex. F. Chen, Sifeng Chen

    Toxicology Letters   302   60 - 74   2019年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.toxlet.2018.11.002

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  • Nuclear magnetic resonance-based metabolomic investigation reveals metabolic perturbations in PM2.5-treated A549 cells 査読

    Dacheng Huang, Yajuan Zou, Anees Abbas, Bona Dai

    Environmental Science and Pollution Research   25 ( 31 )   31656 - 31665   2018年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    DOI： 10.1007/s11356-018-3111-y

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    その他リンク： http://link.springer.com/content/pdf/10.1007/s11356-018-3111-y.pdf

  • The trimeric Hef-associated nuclease HAN is a 3′→5′ exonuclease and is probably involved in DNA repair 査読

    Lei Feng, Chen-Chen Chang, Dong Song, Chuang Jiang, Yang Song, Chao-Fan Wang, Wei Deng, Ya-Juan Zou, Hai-Feng Chen, Xiang Xiao, Feng-Ping Wang, Xi-Peng Liu

    Nucleic Acids Research   46 ( 17 )   9027 - 9043   2018年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Oxford University Press (OUP)  

    DOI： 10.1093/nar/gky707

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  • Physicochemical properties, in vitro cytotoxic and genotoxic effects of PM1.0 and PM2.5 from Shanghai, China 査読

    Yajuan Zou, Yizhao Wu, Yali Wang, Yinsheng Li, Chengyu Jin

    Environmental Science and Pollution Research   24 ( 24 )   19508 - 19516   2017年8月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    DOI： 10.1007/s11356-017-9626-9

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    その他リンク： http://link.springer.com/content/pdf/10.1007/s11356-017-9626-9.pdf

  • Water soluble and insoluble components of urban PM2.5 and their cytotoxic effects on epithelial cells (A549) in vitro 査読

    Yajuan Zou, Chengyu Jin, Yue Su, Jiaru Li, Bangshang Zhu

    Environmental Pollution   212   627 - 635   2016年5月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.envpol.2016.03.022

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  • Transfer of quantum dots from pregnant mice to pups across the placental barrier 査読

    CHU M.

    Small   6 ( 5 )   670 - 678   2010年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/smll.200902049

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講演・口頭発表等

  • Polyglycerol Grafting Shields Nanoparticle from Protein Corona Formation to Avoid Macrophage Uptake 招待

    ZOU Yajuan

    ACSNano-Nanomedicine Journal Club  2022年3月12日 

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  • Polyglycerol Grafting Shields Nanoparticle from Protein Corona Formation to Avoid Macrophage Uptake

    The 10th CSJ Chemistry Festa  2020年10月20日 

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  • The affinity of the charged functional groups on polyglycerol-grafted nanoparticles to proteins dedicates their cellular uptake

    第10回ナノカーボンバイオシンポジウム  2020年9月15日 

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  • Evaluation of polymer content and net charge effects of nanodiamond toward protein affinity

    Yajuan Zou, Naoki Komatsu

    International Workshop on Quantum Sensing and Biophotonics  2019年9月30日 

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  • Quantitative evaluation of polymer density and net charge effects on nanodiamond surface toward protein affinity

    Yajuan Zou, Naoki Komatsu

    European Material Research Society Meeting 2019 Spring Meeting, Symposium M (SGP4A)  2019年5月30日 

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  • Polyglycerol grafted nanoparticles improve stealth effect by resisting protein corona formation: A comparison study to PEG

    Yajuan Zou, Naoki Komatsu

    European Material Research Society 2019 Spring Meeting Symposium L(MXE7G)  2019年5月29日 

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  • The influence of nanodiamond size and surface functionality on protein corona formation and subsequent macrophage uptake

    28th Annual Meeting of The Materials Research Society of Japan  2018年12月19日 

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  • The influence of nanodiamond size and surface functionality on protein corona formation and macrophage uptake

    Japan-Russia Mini-workshop  2018年9月28日 

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  • Fabrication of fluorescent nanodiamond-iron oxide nanocomposites for dual-modal cellular imaging

    Asian symposium on nanoscience and nanotechnology  2018年5月14日 

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産業財産権

  • A new preparation method for modification of active carbon under normal pressure

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    出願番号：特願ZL 2013 1 0227595.X  出願日：2015年8月

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  • A new method for detecting uracil DNA glycosidase activity by using molecular beacon as a substrate

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    出願番号：特願CN101008030  出願日：2007年8月

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受賞

  • Graduate Student Award, European Material Research Society 2019 Spring Meeting

    2019年  

    Yajuan ZOU

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共同研究・競争的資金等の研究

  • Development of polyglycerol-based polymeric nanomotor bearing a stimuli-responsive surface for precise theranostics at deep tumor tissue

    研究課題/領域番号：23K17213  2023年04月 - 2026年03月

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    鄒 亜娟

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    配分額：4680000円 （ 直接経費：3600000円 、 間接経費：1080000円 ）

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  • 「女性教員支援助成金 【研究費配分型】

    2021年12月

    岡山大学 

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