Faculty Profiles - Seiichiro Makihara

Papers - Seiichiro Makihara

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Association between handwashing and gargling education for children and prevention of respiratory tract infections: a longitudinal Japanese children population-based study Reviewed International journal

Kensuke Uraguchi, Toshiharu Mitsuhashi, Naomi Matsumoto, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

European Journal of Pediatrics 182 ( 9 ) 4037 - 4047 2023.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

PURPOSE: A longitudinal study was conducted to examine the effects of handwashing and gargling education for children on the prevention of respiratory tract infections (RTIs) in children in Japan. METHODS: The study included 38,554 children born in 2010 who were enrolled in a longitudinal study. Information on children's hygiene education regarding handwashing and gargling was collected in a survey at the age of 3.5 years. Based on parents' reports of doctors' diagnoses, airway infections and influenza events in the 12-month duration before the survey were evaluated for RTIs at the ages of 4.5 and 9 years. Poisson regression with robust variance was performed to examine the effects of hygiene education on RTIs prevention. The supplementary analysis was stratified by household income. RESULTS: Children were categorized into different groups: 38% in the handwashing and gargling group, 29% in the handwashing group, 0.1% in the gargling group, and 9.7% in the no-education group. Exclusions were made for non-respondent children (23%) and those in the gargling group. Hygiene education was associated with decreased influenza at the age of 4.5 years in the handwashing (adjusted RR [aRR] = 0.8; 95% CI, 0.8-0.9) and handwashing and gargling groups (aRR = 0.8; 95% CI, 0.8-0.9) compared with no education. However, no preventive effects on airway infections at the age of 4.5 and 9, influenza at the age of 9, or hospitalization between the ages of 3.5 and 9 years were detected. Handwashing and gargling could significantly prevent influenza in low-income households (aRR = 0.7; 95% CI, 0.6-0.8). Conclusions: Gargling education was widespread and mostly combined with handwashing education in Japan. Hygiene education significantly affected prevention of influenza infections at the age of 4.5 years, especially in low-income households. WHAT IS KNOWN: • Previous intervention studies showed handwashing and gargling are effective in preventing respiratory tract infections. WHAT IS NEW: • We conducted a longitudinal study on handwashing and gargling education in Japanese children and found that handwashing and gargling were widely practiced together. • Handwashing and gargling education were related to a reduction in influenza, particularly in low-income households.

DOI： 10.1007/s00431-023-05062-5

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Other Link： https://link.springer.com/article/10.1007/s00431-023-05062-5/fulltext.html

Macroarray expression analysis of cytokines and prostaglandin metabolism-related genes in chronic rhinosinusitis Reviewed International journal

Aiko Oka, Kengo Kanai, Takaya Higaki, Seiichiro Makihara, Yohei Noda, Shin Kariya, Mizuo Ando, Wataru Nishimura, Mitsuhiro Okano

Journal of Allergy and Clinical Immunology: Global 2 ( 3 ) 100123 - 100123 2023.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

BACKGROUND: Chronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings. OBJECTIVE: The aim of this study was to analyze the expression of cytokines, prostaglandin (PG) synthases, and their receptors related to the pathogenesis of CRS, especially those contributing to nasal polyp (NP) formation. METHODS: NPs and uncinate tissue (UT) samples were collected from 90 patients who underwent endoscopic sinus surgery. They included 75 patients with CRS (including 45 with eosinophilic CRS [eCRS] and 30 with non-eCRS) and 15 patients without CRS. A total of 30 genes were selected for our original DNA array plate to analyze the levels of expression of 10 cytokines (IFN-γ, IL-4, IL-5, IL-10, IL-13, IL-17A, IL-22, IL-25, IL-33, and TSLP), 4 prostaglandin synthases (prostaglandin D2 [PGD2] synthase, prostaglandin E2 synthase, COX-1, and COX-2), and their 16 receptors. Clustering analysis was performed according to the expression results, and clinical findings of patients from each cluster were investigated. RESULTS: The samples could be divided into 3 clusters. Cluster 1 showed elevated levels of expression of IL4, IL5, IL13, TSLP, IL1RL1 (ST2 [an IL-33 receptor]), HPGDS, and GPR44 (CRTH2, a PGD2 receptor); cluster 2 showed elevated levels of expression of IL17A and PTGES; and cluster 3 showed an elevated level of expression of IL25. Regarding clinical features, the main characteristics of each cluster were as follows: NPs from patients with eCRS for cluster 1, NPs and/or UT samples from patients with non-eCRS for cluster 2, and UTs from patients with non-CRS for cluster 3. CONCLUSION: The results suggest that there are associations between type 2 inflammation/PGD2 and eCRS and also between type 3 inflammation/prostaglandin E2 and non-eCRS.

DOI： 10.1016/j.jacig.2023.100123

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Serum 1,25-dihydroxyvitamin D3 Levels in Patients with Eosinophilic Chronic Rhinosinusitis. Reviewed

Seiichiro Makihara, Shin Kariya, Shotaro Miyamoto, Kensuke Uraguchi, Aiko Oka, Munechika Tsumura, Yohei Noda, Mizuo Ando, Mitsuhiro Okano

Acta medica Okayama 76 ( 5 ) 527 - 533 2022.10

咽喉頭浮腫を合併したムンプス感染症の1例 Reviewed

内藤智之, 牧原靖一郎, 津村宗近, 松本淳也, 假谷伸, 安藤瑞生

耳鼻咽喉科・頭頸部外科 94 ( 11 ) 979 - 982 2022.10

Language：Japanese Publisher：(株)医学書院

＜文献概要＞はじめに流行性耳下腺炎はムンプスウイルスによる感染症であり,耳下腺の腫脹・疼痛や発熱を主症状とする。主に小児期に好発するが,成人発症も少なからず存在する。しばしば感音難聴や髄膜炎,睾丸炎などの合併症を生じるが,咽喉頭浮腫は比較的稀である。過去にも報告例があり1〜20),特に顎下部の腫脹を伴う場合では注意が必要とされている。今回,ムンプスウイルス感染に伴う喉頭浮腫と呼吸困難をきたした症例を経験したので,若干の文献的考察を含め報告する。

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甲状腺悪性リンパ腫に対して輪状軟骨開窓術を施行した1例 Reviewed

松本淳也, 牧原靖一郎, 内藤智之, 土井彰, 小桜謙一, 假谷伸, 安藤瑞生

耳鼻咽喉科臨床 115 ( 7 ) 619 - 624 2022.7

Language：Japanese Publisher：耳鼻咽喉科臨床学会

症例は77歳男性で、2週間前頃から喉頭違和感を自覚しており、当科初診日深夜に呼吸困難が出現したため当院に救急搬送された。精査によりたこつぼ型心筋症と狭心症が明らかとなり、さらにCTで気管狭窄を伴う甲状腺腫瘍が認められた。急速に増大する甲状腺腫瘍であったため、未分化癌や悪性リンパ腫を疑い穿刺吸引細胞診を施行したが、検体不良との結果で診断を得られなかった。早期の確定診断に加え、気道管理の面から経皮的な気道確保への移行が必要と判断し、入院4日目に輪状軟骨開窓術と開放生検を同時に行う方針とした。術後2週目にび漫性大細胞性リンパ腫の確定診断に至り、たこつぼ型心筋症と狭心症は呼吸・循環管理により改善していたため、血液内科に転科のうえ術後21日目から化学療法が開始され、6コース完遂後に腫瘍は完全奏効となった。

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ANL Secondary Publication 感染性副鼻腔嚢胞による鼻性眼窩内合併症の検討

牧原靖一郎, 假谷伸, 岡野光博, 内藤智之, 津村宗近, 西崎和則

日本耳鼻咽喉科頭頸部外科学会会報 125 ( 6 ) 1041 - 1042 2022.6

Subclinical obstructive lung function changes in patients with sinus fungus ball. Reviewed International journal

Seiichiro Makihara, Shin Kariya, Ryotaro Omichi, Shotaro Miyamoto, Tomoyuki Naito, Kensuke Uraguchi, Aiko Oka, Munechika Tsumura, Mitsuhiro Okano, Mizuo Ando

Allergology international : official journal of the Japanese Society of Allergology 71 ( 4 ) 539 - 541 2022.4

Mapping naso-ocular symptom scores to EQ-5D-5L utility values in Japanese cedar pollinosis Reviewed International journal

Hiroshi Kumanomidou, Kengo Kanai, Aiko Oka, Takenori Haruna, Yuji Hirata, Sei ichiro Makihara, Takaya Higaki, Maki Akamatsu, Yoshitaka Okamoto, Shunya Ikeda, Mitsuhiro Okano

Allergology International 71 ( 2 ) 207 - 213 2022.4

Language：English Publishing type：Research paper (scientific journal)

Background: The total naso-ocular symptom score (TSS) is widely used as an endpoint to evaluate the severity of seasonal allergic rhinitis. However, it is not a generic preference-based measure. We sought to develop an algorithm for mapping between the TSS and health utility in Japanese cedar pollinosis (JCP). We also performed a cost-utility analysis of sublingual immunotherapy (SLIT) for JCP by using this algorithm. Methods: Patients with JCP filled out the TSS questionnaire and EQ-5D-5L simultaneously during the pollen season in 2019 and in 2020. We estimated a direct utility mapping model by regressing responses to individual TSS questions directly onto utility. The incremental cost-effectiveness ratio (ICER) of active SLIT to a placebo was determined by examining the drug expense and the estimated quality-adjusted life year (QALY) using a dataset from a double-blind placebo-controlled clinical trial. Results: A total of 238 records were included for analysis. The estimated utility decreased with increasing severity of rhinitis. Patients with comorbid asthma showed lower utility. A negative and significant correlation was seen between the TSS and utility in both 2019 and 2020. The estimated equations were: Y(utility) = −0.0161∗X(TSS) + 1.005 in non-asthmatic JCP patients. The ICER of active SLIT to the placebo was estimated to be 4,049,720 and 6,011,218 JPY/QALY in the first and second year, respectively. Conclusions: It is possible to reasonably predict utility from the total naso-ocular symptom score by using regression models. In the estimated algorithm, pre-seasonal SLIT for JCP is cost-effective.

DOI： 10.1016/j.alit.2021.11.002

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【CT典型所見アトラス-まずはここを診る!】鼻副鼻腔領域鼻副鼻腔腫瘍/頭蓋底疾患乳頭腫/血瘤腫・血管腫・血管線維腫/鼻副鼻腔悪性腫瘍(上顎がん・嗅神経芽細胞腫)/髄膜脳瘤・髄膜瘤

牧原靖一郎, 假谷伸

耳鼻咽喉科・頭頸部外科 94 ( 4 ) 336 - 341 2022.4

Authorship：Lead author,　Corresponding author Language：Japanese Publisher：(株)医学書院

＜文献概要＞POINT ▼内反性乳頭腫の基部推定には,骨肥厚像,もしくは骨融解像が重要である。▼血管線維腫は蝶口蓋孔を中心に周囲に広がる腫瘤で,造影CTで強く濃染される。▼上顎がんは隣接する副鼻腔の骨破壊を生じ,壊死部位により内部不均一となる。▼頭蓋底に発生した髄膜脳瘤は,頭蓋底の骨欠損を介し,頭蓋内からの脳組織の脱出,脳溝の連続を認める。

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Clinicopathologic Analysis of Sinonasal Inverted Papilloma, with Focus on Human Papillomavirus Infection Status. Reviewed International journal

Munechika Tsumura, Seiichiro Makihara, Asami Nishikori, Yuka Gion, Toshiaki Morito, Shotaro Miyamoto, Tomoyuki Naito, Kensuke Uraguchi, Aiko Oka, Tomoyasu Tachibana, Yorihisa Orita, Shin Kariya, Mitsuhiro Okano, Mizuo Ando, Yasuharu Sato

Diagnostics (Basel, Switzerland) 12 ( 2 ) 2022.2

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI

Sinonasal inverted papilloma (SNIP) can recur; however, the factors related to tumor recurrence remain unclear. This study aimed to analyze risk factors, including human papillomavirus (HPV) infection, as well as other factors associated with SNIP recurrence. Thirty-two patients who were diagnosed with SNIP and underwent surgery between 2010 and 2019 were enrolled: 24 men and 8 women, with a mean age of 59.2 years. The mean follow-up was 57.3 months. Demographics and information about history of smoking, diabetes mellitus (DM), hypertension, allergic rhinitis, alcohol consumption, tumor stage, surgical approach, and recurrence were reviewed retrospectively. Specimens were investigated using polymerase chain reaction to detect HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11). Seven patients (21.9%) experienced recurrence. HPV DNA was detected in five (15.6%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 3). Patients with recurrence of SNIP had a higher proportion of young adults and displayed higher rates of HPV infection, DM, and advanced tumor stage than those without recurrence. HPV infection, young adulthood, DM, and advanced tumor stage could be associated with a high recurrence rate, which suggests that patients with these risk factors could require close follow-up after surgery.

DOI： 10.3390/diagnostics12020454

Dermatomyositis With Carcinoma of Unknown Primary Disease in the Head and Neck Diagnosed by Muscle Biopsy During Neck Dissection. Reviewed International journal

Kensuke Uraguchi, Seiichiro Makihara, Makoto Tsugita, Toshiaki Morito, Shin Kariya, Mizuo Ando

JAMA otolaryngology-- head & neck surgery 148 ( 2 ) 195 - 196 2022.2

TACMI法とEndoscopic Denker's Approachの併用により摘出しえた鼻腔血管腫の1例 Reviewed

松本淳也, 牧原靖一郎, 大村和弘, 内藤智之, 土井彰, 假谷伸, 安藤瑞生

頭頸部外科 31 ( 3 ) 293 - 299 2022.2

Language：Japanese Publisher：(NPO)日本頭頸部外科学会

巨大な鼻腔血管腫の手術では良好な視野の確保が困難となることが多く,また術中に大量出血をきたすことがあるため,術式の選択が重要とされる。本症例は,78歳女性,左鼻腔を充満する血管腫症例である。術前塞栓術を試みたが施行できなかったため,手術の最初に栄養血管である蝶口蓋動脈の処理が必要であった。TACMI法とEndoscopic Denker's Approachを併用することで,蝶口蓋動脈凝固切断後の腫瘍の一塊切除が,内視鏡下に可能となった。これらの術式の併用は,巨大な鼻腔腫瘍,特に蝶口蓋動脈の処理も必要な場面において有用であると考えられた。(著者抄録)

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Endoscopic tri-port approach法にて一塊切除した若年性血管線維腫例 Reviewed

牧原靖一郎, 大村和弘, 宮本翔太郎, 内藤智之, 浦口健介, 津村宗近, 假谷伸, 岡野光博, 安藤瑞生

日本鼻科学会会誌 60 ( 4 ) 546 - 552 2021.12

Authorship：Lead author,　Corresponding author Language：Japanese Publisher：(一社)日本鼻科学会

若年性血管線維腫は思春期男性に好発する易出血性の血管性腫瘍で,局所浸潤性が高く,鼻腔内から翼口蓋窩を中心に周囲組織を破壊進展する。手術療法は,様々な外切開が適応とされることが多かったが,近年では手術器具,技術,ナビゲーションシステムなどの進歩により経鼻内視鏡下に摘出される報告が増えている。Endoscopic tri-port approach法とは,Omuraらの提唱したTransseptal access with crossing multiple incisions(TACMI法),Direct approach to the anterior and lateral part of the maxillary sinus with an endoscope(DALMA法)と,Weberらの提唱した鼻涙管切断を伴う下鼻甲介処置を組み合わせることで,両外鼻孔からの経鼻中隔,経鼻腔,経上顎洞前壁の3つのポートを使用して,0度の内視鏡で翼口蓋窩や眼窩などへアプローチする方法である。今回我々は17歳の男性で,鼻腔,上咽頭から翼口蓋窩に一部進展の認める若年性血管線維腫,Radkowski分類Stage IIA期に対して,術前日に選択的血管塞栓術を施行した後に,Endoscopic tri-port approach法にて一塊切除した。Endoscopic tri-port approach法は顔面の外切開や歯齦部切開を施行することなく,可能な限り鼻中隔や下鼻甲介を温存しながら,広い術野で病変部への到達が可能であり,翼口蓋窩進展を認める若年性血管線維腫に対して有用なアプローチ法と考えられた。(著者抄録)

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Total en bloc resection for sinonasal squamous cell carcinoma by endoscopic endonasal surgery with Draf IIb procedure with video Reviewed

K. Uraguchi, S. Makihara, K. Kozakura

European Annals of Otorhinolaryngology, Head and Neck Diseases 138 119 - 121 2021.11

【手術道具・材料はこう使う!-プロに学ぶ基本とコツ】鼻科領域止血資材/創傷被覆材/フィブリン糊

牧原靖一郎

耳鼻咽喉科・頭頸部外科 93 ( 11 ) 915 - 919 2021.10

Authorship：Lead author,　Corresponding author Language：Japanese Publisher：(株)医学書院

＜文献概要＞Point ▼鼻副鼻腔内からの出血に対する止血方法の基本は,出血点を同定して凝固焼灼止血を行うことである。▼止血資材には,外来での鼻出血に対する処置などに使用される酸化セルロースやゼラチンスポンジ,主に頭蓋底手術に使用されるゼラチン・ヒトトロンビン合材など,状況に応じた選択肢がある。▼内視鏡下鼻内副鼻腔手術(ESS)終了後のパッキング資材として,圧迫による癒着予防効果をもち,吸引除去が可能なナゾポアが有用である。

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Underwater posterior nasal neurectomy compared to resection of peripheral branches of posterior nerve in severe allergic rhinitis. Reviewed International journal

Seiichiro Makihara, Mitsuhiro Okano, Syotaro Miyamoto, Kensuke Uraguchi, Munechika Tsumura, Shin Kariya, Mizuo Ando

Acta oto-laryngologica 141 ( 8 ) 780 - 785 2021.8

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：TAYLOR & FRANCIS LTD

BACKGROUND: Several surgical procedures for posterior nasal neurectomy have been reported, but no conclusion has been reached about which procedure is best. OBJECTIVES: The aim is to evaluate the improvement in symptom medication scores for resection of the posterior nasal nerve trunk in an underwater environment, with submucous inferior turbinectomy, without injuring the sphenopalatine artery (SPA) in severe allergic rhinitis. MATERIAL AND METHODS: Improvements in symptom medication scores were retrospectively compared between 27 consecutive cases who underwent resection of the posterior nasal nerve trunk with turbinoplasty in an underwater environment without injuring the SPA (Underwater group) and, as a historical control, 16 consecutive cases who underwent resection of peripheral branches of the posterior nasal nerve with turbinoplasty (Control group). RESULTS: The improvements in symptom medication scores in the Underwater group were significantly better than in the Control group (3.07 vs. 1.96, p = 0.02). CONCLUSIONS AND SIGNIFICANCE: By using underwater posterior nasal neurectomy, we can easily and safely resect the posterior nasal nerve trunk under a clear surgical view without injuring the SPA. This technique with submucous inferior turbinectomy may, more than resection of peripheral branches of the posterior nasal nerve, be able to reduce the medication score and symptom medication score.

DOI： 10.1080/00016489.2021.1925151

Dysphagia in a Patient with Asymmetric Elevation of the Hyoid Bone. Reviewed International journal

Kensuke Uraguchi, Seiichiro Makihara, Shin Kariya

Dysphagia 36 ( 4 ) 761 - 763 2021.8

経鼻内視鏡手術で摘出したskip病変を伴う鼻腔粘膜悪性黒色腫症例 Reviewed

浦口健介, 小桜謙一, 牧原靖一郎, 土井彰, 假谷伸

日本鼻科学会会誌 60 ( 1 ) 1 - 5 2021.4

Language：Japanese Publisher：(一社)日本鼻科学会

鼻腔粘膜悪性黒色腫に関しては手術が可能な場合は手術が第一選択とされており,近年では内視鏡手術が選択される事が多くなってきている。今回,経鼻内視鏡手術で摘出したskip病変を伴う鼻腔粘膜悪性黒色腫の1例を経験したため報告する。症例は86歳男性。鼻腔腫瘍からの反復性鼻出血のため当科紹介された。腫瘍生検で鼻腔粘膜悪性黒色腫の診断となり全身麻酔下で経鼻内視鏡手術を行った。術後の鼻腔内視鏡検査で右上顎洞にskip病変を認めた。初回手術2ヵ月後に根治目的でendoscopic medial maxillectomy(EMM)を行ったところ,術前に指摘できなかったskip病変が右下鼻道にも認められた。現在,再手術後3年半経過しているが再発や転移を認めていない。(著者抄録)

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Effect of Prostaglandin D<inf>2</inf> on mRNA Expression of Three Isoforms of Hyaluronic Acid Synthase in Nasal Polyp Fibroblasts Reviewed International journal

Yuji Hirata, Shin Kariya, Kengo Kanai, Tazuko Fujiwara, Sei Ichiro Makihara, Ryotaro Omichi, Takaya Higaki, Takenori Haruna, Aiko Oka, Kazunori Nishizaki, Mitsuhiro Okano

American Journal of Rhinology and Allergy 35 ( 1 ) 44 - 51 2021.1

Language：English Publishing type：Research paper (scientific journal)

Background: Hyaluronan is one of the major extracellular matrixes in chronic rhinosinusitis (CRS) associated with tissue remodeling. Prostaglandin D2 (PGD2) is also associated with the pathogenesis of CRS. However, little is known about whether PGD2 regulates hyaluronan production by human airway fibroblasts. Objective: We sought to determine the effect of PGD2 on the mRNA expression of three isoforms of membrane-bound hyaluronic acid synthase (HAS1, HAS2 and HAS3) in fibroblasts, the major source of hyaluronan production, derived from CRS patients. Methods: Nasal polyp-derived fibroblasts (NPDF) and uncinate tissue-derived fibroblasts (UTDF) were established from CRS patients with nasal polyps and those without, respectively. These fibroblasts were stimulated with PGD2 or PGD2 receptor (DP/CRTH2)-selective agonists in the presence or absence of receptor-selective antagonists. mRNA levels for HAS1, HAS2 and HAS3 were determined by real-time quantitative PCR. Results: PGD2 (1 µM) significantly enhanced HAS1 but not HAS2 or HAS3 mRNA expression by NPDF. Enhanced HAS1 mRNA expression was also obtained by stimulation with a DP receptor-selective agonist, but not with a CRTH2 receptor-selective agonist. In addition, PGD2-induced HAS1 mRNA expression was significantly inhibited by pre-treatment with DP receptor-selective antagonists. Similar induction of PGD2-induced HAS1 mRNA expression was seen in UTDF. Conclusion: PGD2 selectively stimulates HAS1 mRNA expression in local fibroblasts in CRS via DP, but not CRTH2, receptors.

DOI： 10.1177/1945892420932781

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A case of rhinocerebral mucormycosis with brain abscess drained by endoscopic endonasal skull base surgery. Reviewed International journal

Kensuke Uraguchi, Kenichi Kozakura, Satoshi Oka, Takaya Higaki, Seiichiro Makihara, Toshi Imai, Akira Doi, Tsuyoshi Ohta, Shin Kariya, Kazunori Nishizaki

Medical mycology case reports 30 22 - 25 2020.12

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER

A 70-year-old Japanese man undergoing remission induction therapy for acute monocytic leukemia (AML-M5b) developed fever and headache, and was started on antibiotics and liposomal amphotericin B (L-AMB). There was no improvement, and computed tomography and contrast-enhanced magnetic resonance imaging revealed acute rhinosinusitis and brain abscess. Successful endoscopic endonasal surgery was performed at this point, providing drainage for the rhinosinusitis and abscess. Histopathological findings showed the mucormycosis.

DOI： 10.1016/j.mmcr.2020.09.004

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