Updated on 2024/02/08

写真a

 
YAMASAKI Yukie
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
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Degree

  • Doctor of Philosophy in Medical Science ( 2019.3   Okayama University )

Professional Memberships

 

Papers

  • Successful Cardiac, Lung, and Kidney Transplantation from a Methanol-poisoned Donor.

    Takashi Hongo, Tetsuya Yumoto, Yoshinori Kosaki, Tomohiro Hiraoka, Kohei Tsukahara, Tsuyoshi Nojima, Takafumi Obara, Kohei Ageta, Yukie Yamasaki, Kaori Taniguchi, Masanobu Miura, Satoru Miyaishi, Hiromichi Naito, Atsunori Nakao

    JMA journal   7 ( 1 )   133 - 135   2024.1

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    Massive methanol exposure can lead to severe and detrimental effects that can result in death or brain death. As organs from patients with brain death after methanol ingestion are less likely to be recovered, these patients have been considered marginal donors. We present a case of successful multiple organ transplantation (heart, lungs, and kidneys) from a methanol-poisoned patient. Our experience illustrates that donor death from methanol intoxication does not preclude organ transplantation.

    DOI: 10.31662/jmaj.2023-0081

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  • The role of legal medicine in mass disaster : A report on the activity of the Department of Legal Medicine of Okayama University for the postmortem examination following the Great East Japan Earthquake

    Miura Masanobu, Miyaishi Satoru, Taniguchi Kaori, Yamasaki Yukie, Kobayashi Chie, Takei Sella, Aoki Yasuhiro

    Okayama Igakkai Zasshi (Journal of Okayama Medical Association)   134 ( 2 )   108 - 114   2022.8

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    Language:Japanese   Publisher:Okayama Medical Association  

    DOI: 10.4044/joma.134.108

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  • 乳幼児突然死症候群は減少しているか? 人口動態統計を用いた乳児突然死の実態分析

    山崎 雪恵, 谷口 香, 宮石 智

    日本SIDS・乳幼児突然死予防学会雑誌   19 ( 1 )   7 - 14   2019.12

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    Language:Japanese   Publisher:日本SIDS・乳幼児突然死予防学会  

    日本における乳幼児突然死症候群(SIDS)の定義は、1982年、1994年、2005年、2012年と複数回の変遷がある。今回、過去約40年間のSIDSの定義等の変遷が乳児死亡率にどのような変化として現れたか調査し、SIDS死亡率の都道府県によるばらつきについて検討した。SIDS死亡率は、1985年から1995年にかけては年間10.5〜22.9%の割合で増加し、1995年の44.3をピークとして2007年にかけては年平均9.1%で減少していた。乳児総死亡率は調査期間を通して漸減しているのに対し、乳児突然死の死亡率は1985年から1995年にかけては年間5.5%で増加し、1995年から2002年にかけては8.3%で減少していた。また、2006年から2016年の11年間で標準化死亡比が有意に高かったのは8道県(北海道、宮城県、神奈川県、島根県、山口県、福岡県、宮崎県、沖縄県)、低かったのは11都府県(茨城県、栃木県、群馬県、東京都、石川県、福井県、愛知県、滋賀県、京都府、大阪府、和歌山県、岡山県)となり、前5年間よりも都道府県間の差がみられるようになった。

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  • Unintentional Injury Deaths among Children: A Descriptive Study Using Medico-legal Documents in Okayama Prefecture, Japan (2001-2015).

    Yukie Yamasaki, Nanako Tamiya, Hideki Yamamoto, Satoru Miyaishi

    Acta medica Okayama   73 ( 2 )   117 - 125   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    According to the World Health Organization's World Report, approx. 950,000 children and young people < 18 years old die from an injury each year, and unintentional injury deaths account for a large portion of these cases. Here we used medico-legal documents to epidemiologically analyze the cases of unintentional injury deaths among children < 5 years old in Okayama Prefecture, Japan from 2001 to 2015. Age, sex, manner/cause of death, and various circumstances of the incident were investigated. There were 73 unintentional injury deaths during the study period. Drowning (n=29), suffocation (n=24), and transport accidents (n=13) were the major categories of unintentional injury deaths. Twenty-two cases (30.1%) were autopsied. Differences in the characteristics of the unintentional injury deaths by age were observed. Information which cannot be obtained from Vital Statistics was available from medico-legal documents, and detailed characteristics of unintentional injury deaths among children < 5 years old were elucidated. Investigating medico-legal information is one of the meaningful measures for the prevention of unintentional injury deaths among children in Japan.

    DOI: 10.18926/AMO/56647

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  • Measurement of Postmortem 1,5-anhydroglucitol in Vitreous Humor for Forensic Diagnosis. International journal

    Tomoyo Takata, Yukie Yamasaki, Takashi Kitao, Satoru Miyaishi

    Journal of forensic sciences   61 Suppl 1   S150-3   2016.1

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    In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5-anhydroglucitol (1,5-AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5-AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5-AG concentrations in vitreous humor (mean±SD: 20.2 ± 8.7 μg/mL) and CSF (16.8 ± 8.7 μg/mL) did not differ significantly and showed a strong correlation (r(2) = 0.87, p < 0.01). These results suggest that the vitreous humor 1,5-AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5-AG concentration.

    DOI: 10.1111/1556-4029.12963

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  • Child deaths with persistent neglected experiences from medico-legal documents in Japan. International journal

    Yui Yamaoka, Nanako Tamiya, Takeo Fujiwara, Yukie Yamasaki, Akemi Matsuzawa, Satoru Miyaishi

    Pediatrics international : official journal of the Japan Pediatric Society   57 ( 3 )   373 - 80   2015.6

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    BACKGROUND: Few studies have examined the actual conditions of fatal neglect in Japan. The aims of this study were to investigate persistent neglect among child fatalities using medico-legal documents, and to describe the characteristics of the socio-familial background and biological data. METHODS: The current study analyzed the documents of all postmortem external examinations and autopsies in children <2 years old carried out in one prefecture in Japan from 2006 to 2011. After examining 59 autopsy cases using modified the Maltreatment Classification System, we identified six children who experienced persistent neglect as study samples. RESULTS: Three children were found in unsanitary rooms and one was left alone inside a car. In two cases, age of mother at delivery was <21 years old. Three victims had 1 year older sibling. With regard to history of use of health services, three mothers missed some prenatal care visits, and two refused to receive neonatal home visits. With regard to biological data the average weight Z score of six children was -2.22 after being adjusted to average weight for age (in months) and sex. Three children had acute or chronic undernutrition. Three victims had thymic involution considered as being due to chronic child maltreatment. CONCLUSIONS: The present collaboration between public health and legal medicine has enabled investigation of the background and biological impact of experiences of persistent neglect. A multidisciplinary system of evaluating child death is needed to identify preventable factors in order to intervene in the case of neglected children in a timely manner.

    DOI: 10.1111/ped.12531

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  • 自転車自損死亡事故の実態把握における法医剖検情報の有用性

    三浦 雅布, 山崎 雪恵, 井澗 美希, 吉留 敬, 山本 雄二, 宮石 智

    日本医事新報   ( 4750 )   38 - 42   2015.5

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    Language:Japanese   Publisher:(株)日本医事新報社  

    自転車死亡事故例を自損死亡に限って検討した報告はほとんどなく、筆者らは自転車自損死亡事故事案の剖検例に着目した。2007〜11年に、当教室で自転車自損死亡事故により解剖となった17例を調査した。直接死因は転落に伴う頸椎損傷が最多で、ついで溺死が多かった。アルコール陽性例は64.7%であり、事故現場は用水・側溝などへの転落がほとんどであったことから、飲酒運転禁止の徹底、転落防止柵の設置、側溝の蓋の整備などが必要であると思われた。一方、岡山県の交通年鑑による同期間の自転車自損死亡事故数は12例で、解剖数との間に乖離があり、正確な実態把握のためには法医剖検例からの情報が必須であると考えられた。(著者抄録)

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J01024&link_issn=&doc_id=20150512030005&doc_link_id=%2Faf9mdcla%2F2015%2F004750%2F013%2F0038-0042%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faf9mdcla%2F2015%2F004750%2F013%2F0038-0042%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • Usefulness of postmortem 1,5-anhydroglucitol analysis in forensic diagnosis Reviewed

    TAKATA Tomoyo, YAMASAKI Yukie, KITAO Takashi, MIYAISHI Satoru

    Japanese Journal of Medical Technology   63 ( 6 )   680 - 686   2014

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    Language:Japanese   Publisher:Japanese Association of Medical Technologists  

    For postmortem diagnosis of diabetes mellitus including fulminant type 1 diabetes, it is necessary to determine the blood glucose concentration before death, and the concentrations of plasma and cerebrospinal fluid 1,5-anhydroglucitol (1,5-AG) and HbA1c were investigated in 59 individuals including diabetic patients (n = 13) and nondiabetic subjects (n = 46) without renal failure on the basis of anamnesis. The postmortem 1,5-AG concentration in the plasma showed linearity with that in the cerebrospinal fluid (r = 0.59). The mean 1,5-AG concentrations in the plasma and cerebrospinal fluid were significantly lower in diabetes mellitus patients than in nondiabetic subjects (plasma 1,5-AG: 6.8 ± 8.3 µg/mL (diabetes mellitus) vs 23.6 ± 13.0 µg/mL (nondiabetes mellitus); cerebrospinal fluid 1,5-AG: 6.1 ± 5.3 µg/mL (diabetes mellitus) vs 19.4 ± 7.9 µg/mL (nondiabetes mellitus)). The plasma and/or cerebrospinal fluid 1,5-AG concentrations in all the diabetic patients were low. Furthermore, the plasma and cerebrospinal fluid 1,5-AG concentrations in nondiabetic subjects with HbA1c 6.5% or more was low. In nondiabetic subjects with normal HbA1c, only the plasma 1,5-AG concentration was low in those who died because of drowning. In conclusion, we consider that measurements of plasma and cerebrospinal fluid 1,5-AG concentrations in addition to HbA1c concentration are useful for the forensic diagnosis of postmortem diabetes mellitus including fulminant type 1 diabetes, and it is better to apply the measurement of cerebrospinal fluid 1,5-AG concentration in those who died because of drowning.

    DOI: 10.14932/jamt.14-13

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    Other Link: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670343/

  • Symptom definitions for SBS (sick building syndrome) in residential dwellings. International journal

    Bing-Ling Wang, Tomoko Takigawa, Yukie Yamasaki, Noriko Sakano, Da-Hong Wang, Keiki Ogino

    International journal of hygiene and environmental health   211 ( 1-2 )   114 - 20   2008.3

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    The potential risk factors for sick building syndrome (SBS) in newly built dwellings were investigated. Two different definitions for SBS were used, a narrow definition (symptoms related to home environment and continuously occurring in the last 3 months were regarded as positive) and another relatively broad definition (symptoms related to home environment and either continuously or sporadically occurring in the last 3 months were regarded as positive). With both definitions indoor air chemicals, especially TVOC, and high stress during work were found to be significantly associated with SBS symptoms. Allergic history was more associated with narrow-sense symptoms and odor perception with broad-sense symptoms. The results indicate that the broad definition be preferred to find more potential risk factors.

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  • Unmetabolized VOCs in urine as biomarkers of low level exposure in indoor environments. International journal

    Bing-Ling Wang, Tomoko Takigawa, Akito Takeuchi, Yukie Yamasaki, Hiroyuki Kataoka, Da-Hong Wang, Keiki Ogino

    Journal of occupational health   49 ( 2 )   104 - 10   2007.3

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    This study aimed to test the possible use of unmetabolized volatile organic compounds (VOCs) in urine as biomarkers of low-level indoor environmental exposure. Twenty-four subjects in 13 dwellings in a prefecture of Japan participated in this study. Air samples of the breathing zone were collected in the living room and bedroom, along with spot urine samples (before bedtime and first morning voids). Toluene, ethylbenzene, xylene isomers, styrene and p-dichlorobenzene in the air and urine samples were measured by gas chromatography/mass spectrometry. For the 21 subjects without solvent exposure at work, there were significant correlations between the time-weighted average air concentrations in the bedroom and morning urinary concentrations for toluene, o-xylene, total xylene and p-dichlorobenzene (correlation coefficients of 0.54, 0.61, 0.56 and 0.84, respectively). Multiple linear regression analysis showed only air VOCs in the bedroom influenced the morning urinary VOC concentrations. We concluded that unmetabolized VOCs in the urine can provide a reliable biological indicator for air VOC exposures in non-occupational environments.

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  • Practicality of Veterans Specific Activity Questionnaire in evaluation of exercise capacity of community-dwelling Japanese elderly.

    Shinji Kojima, Da-Hong Wang, Kimihiko Tokumori, Noriko Sakano, Yukie Yamasaki, Yoko Takemura, Carmen M Kurosawa, Sakiko Kanbara, Takashi Oka, Kohei Hara, Satoru Ikeda, Keiki Ogino

    Environmental health and preventive medicine   11 ( 6 )   313 - 20   2006.11

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    OBJECTIVE: The aim of this study is to determine whether a questionnaire-based method using the Veterans Specific Activity Questionnaire (VSAQ) is a practical tool for the development of a safe exercise program to prevent a reduction in physical performance. METHODS: One hundred and twenty-one senior residents of Yakage, Okayama, agreed to voluntarily participate in this study. They were asked to complete a questionnaire for information on age, sex, subjective health status, exercise habits and VSAQ. We investigated the relationship between age and exercise capacity predicted by VSAQ (predicted metabolic equivalents (METs)). In addition, for 36 out of the 121 participants, we performed a 6-min walk distance test (6MD) and investigated whether its results correlate with the predicted METs. Furthermore, we prepared a modified VSAQ and examined its practicality in the evaluation of the exercise capacity of Japanese elderly (n=50). RESULTS: We found that the predicted METs correlate well with age. Habitual exercise and subjective health status did not affect the predicted METs. A significant correlation was observed between the predicted METs and the results of 6MD (r=0.56, p<0.001). We also found that certain activities included in the original VSAQ are unfamiliar to Japanese elderly; thus, we made a few modifications to the original VSAQ in order to evaluate the physical fitness of Japanese elderly. The number of inadequate answers was reduced by employing the modified VSAQ. CONCLUSION: These findings imply that the modified VSAQ is useful in evaluating the exercise capacity of Japanese elderly adequately and is a practical scale for safe exercise.

    DOI: 10.1007/BF02898022

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MISC

  • 災害時の多数死体検案 平成30年7月豪雨における岡山大学法医学分野の活動

    三浦 雅布, 谷口 香, 山崎 雪恵, 小林 智瑛, Thu Thu Htike, 山本 雄二, 宮石 智

    法医病理   27 ( 2 )   165 - 172   2022.3

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    Language:Japanese   Publisher:日本法医病理学会  

    気象庁により「平成30年7月豪雨」と命名された記録的な大雨により、岡山県倉敷市真備町では、単一地域に発生した数としては全国最多の51名の死者を数える甚大な浸水被害が発生した。これに伴い、岡山大学法医学分野では6日間に延べ8名の医師を現地派遣して、50名の死体検案を行った。東日本大震災での経験を受けての準備や訓練が十分になされていたことから、検案業務自体は滞りなく遂行された。しかしながら、検案時にもたらされた浸水状況の情報には誤りがあり、17名について「死亡したとき」の訂正が必要になった。また、最初に死体検案依頼を受けた時点では複数の指揮系統が動いていたこと、死体検案場所及び死体安置所として事前指定されていた施設が実際には使用できなかったことなど、予期されていなかった問題が、災害が発生してから詳らかになった。災害の多いわが国においては、法医学者が多数死体検案に従事する機会は少なくないと思われ、多彩な災害への対応に備えて経験を共有することが望まれる。(著者抄録)

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  • 法医病理アトラス 硫化水素中毒

    谷口 香, 三浦 雅布, 吉留 敬, 山崎 雪恵, 宮石 智

    法医病理   24 ( 1 )   66 - 67   2018.6

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  • 法医病理アトラス 腐敗網

    三浦 雅布, 谷口 香, 山崎 雪恵, Thu Thu Htike, 小林 智瑛, 宮石 智

    法医病理   23 ( 2 )   91 - 92   2017.12

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  • Relationship between Indoor Air Pollutants and Living Environment and Subjective Symptoms

    YAMASAKI Yukie, WANG Bingling, SAKANO Noriko, WANG Dahong, TAKIGAWA Tomoko

    Indoor Environment : Journal of Society of Indoor Environment, Japan   9 ( 1 )   25 - 36   2006

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    Language:Japanese   Publisher:Society of Indoor Environment, Japan  

    Sick House Syndrome (SHS) is characterized by subjective responses to indoor air contamination. Frequent symptoms include eye, skin, and nose irritation, headache, and fatigue. Although some environmental factors have been put forth as being involved in the occurrence of the symptoms, none has been proved. To clarify the relationship between subjective symptoms of SHS, indoor air pollutants, and the living environment, we took environmental measurements of organic compounds, fungal levels,and house dust mite allergens in ordinary houses in Okayama, Japan and administered questionnaires to their inhabitants. We defined persons complaining of one or more of six subjective symptoms related to the dwelling environment as SHS. In this study, 42 people (17.0%) had SHS. Factors significantly related to SHS were: a moldy odor, perception of an odor in the dwelling, a feeling that the air is bad in the dwelling, perception of an odor from the furniture, sleeplessness, and a history of allergic diseases. People with SHS lived in the dwellings with higher concentrations of some aldehydes and Fusarium. In multiple logistic regression analysis, significant causative factors of SHS were: a moldy odor, a feeling that the air is bad in the dwelling, and sleeplessness. Although organic compounds and house dust mites showed no relationship to SHS, higher fungal levels were found in the dwellings where people had SHS. These results suggest that dampness in dwellings is an important factor in SHS.

    DOI: 10.11510/siej1998.9.1_25

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Presentations

  • 法医解剖からみた農業関連死

    宮石智, 山崎雪恵

    第82回日本公衆衛生学会総会  2023.11.2 

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    Event date: 2023.10.31 - 2023.11.2

    Presentation type:Symposium, workshop panel (public)  

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  • 自宅で死亡した事例の発見までに時間を要する要因の検討

    山崎雪恵, 三浦雅布, 田宮菜奈子, 山本秀樹, 宮石智

    第82回日本公衆衛生学会総会  2023.10.31 

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    Event date: 2023.10.31 - 2023.11.2

    Presentation type:Poster presentation  

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  • 指定外容器に保存した尿を用いたミオグロビン濃度定量の意義

    竹居 セラ, 小林 智瑛, 三浦 雅布, 山崎 雪恵, 宮石 智

    法医病理  2020.1  日本法医病理学会

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    Event date: 2020.1

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  • 心臓血中アルコール濃度への誤嚥の影響 実際例からの考察

    竹居 セラ, 山崎 雪恵, 三浦 雅布, 有吉 雪乃, 守屋 文夫, 宮石 智

    中毒研究  2019.3  (株)へるす出版

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    Event date: 2019.3

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  • 乳幼児突然死症候群 (SIDS)死亡率は減少しているか?—人口動態統計でみた乳児突然死

    山崎雪恵

    第25回日本SIDS・乳幼児突然死予防学会学術集会  2019.2 

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    Event date: 2019.2.22 - 2019.2.23

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  • 総肺静脈還流異常症による乳児突然死の2剖検例

    伊藤 啓, 三浦 雅布, 谷口 香, 山崎 雪恵, 宮石 智

    法医病理  2018.12  日本法医病理学会

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    Event date: 2018.12

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  • 法医解剖における血液培養の有用性について

    小林 智瑛, 三浦 雅布, 山崎 雪恵, 宮石 智

    法医病理  2018.12  日本法医病理学会

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    Event date: 2018.12

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  • 乳幼児突然死症候群 (SIDS) 死亡率の年次変化と地域差に関する考察

    山崎雪恵, 田宮菜奈子, 山本秀樹, 宮石智

    第77回日本公衆衛生学会総会  2018.10 

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    Event date: 2018.10.24 - 2018.10.26

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  • 岡山県における用水路での死亡事故の特徴

    山崎雪恵, 田宮菜奈子, 山本秀樹, 宮石智

    2017.10 

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    Event date: 2017.10.31 - 2017.11.2

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  • 徘徊行動に関連した死亡事例に関する考察

    三浦 雅布, 山崎 雪恵, 宮石 智

    日本法医学雑誌  2016.5  (NPO)日本法医学会

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    Event date: 2016.5

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  • 臨床医による死後CT読影の現状

    谷口 香, 三浦 雅布, 山崎 雪恵, 宮石 智

    日本法医学雑誌  2015.5  (NPO)日本法医学会

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    Event date: 2015.5

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  • 慢性硬膜下血腫を伴う洗剤誤飲による中毒死の一例

    吉留 敬, 三浦 雅布, 山崎 雪恵, 井澗 美希, 谷口 香, 山本 雄二, 宮石 智

    中毒研究  2015.3  (株)へるす出版

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    Event date: 2015.3

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  • 自転車運転中死亡事例の疫学的検討

    宮石 智, 山崎 雪恵, 三浦 雅布

    日本法医学雑誌  2014.12  (NPO)日本法医学会

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    Event date: 2014.12

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  • 法医学における乳幼児死亡統計の検討

    宮石 智, 山崎 雪恵, 谷口 香

    日本法医学雑誌  2014.5  (NPO)日本法医学会

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    Event date: 2014.5

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  • Haaseおよび榊の式による嬰児・新生児の発育程度推定の検証

    山崎 雪恵, 水谷 靖司, 三浦 雅布, 井澗 美希, 難波 令匡, 宮石 智

    日本法医学雑誌  2013.12  (NPO)日本法医学会

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    Event date: 2013.12

    Language:Japanese  

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  • 岡山県における未成年の不慮の事故死亡例についての統計的考察

    山崎 雪恵, 田宮 菜奈子, 宮石 智

    日本法医学雑誌  2013.5  (NPO)日本法医学会

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    Event date: 2013.5

    Language:Japanese  

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  • 解剖となった自宅死亡事例の背景要因の検討

    山崎雪恵, 田宮菜奈子, 山本秀樹, 谷口香, 小林智瑛, 宮石智

    第107次日本法医学会学術全国集会  2023.6.7 

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  • 法医剖検例における肝炎,HIVおよびトレポネーマ等の抗原・抗体検査の陽性率の考察

    山崎雪恵, 三浦雅布, 田宮菜奈子, 山本秀樹, 宮石智

    第81回日本公衆衛生学会  2022.10 

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  • 法医解剖死体におけるB型肝炎ウイルス感染の現況

    山崎雪恵, 小林智瑛, 谷口香, 竹居セラ, 三浦雅布, 吉留敬, 宮石智

    第106次日本法医学会学術全国集会  2022.6.9 

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  • 認知症高齢者の屋外死亡事例の記述疫学的考察

    山崎雪恵, 三浦雅布, 田宮菜奈子, 山本秀樹, 宮石智

    第79回日本公衆衛生学会総会  2020.10 

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  • 統計からみた乳児突然死の死因解明状況に関する一考察

    山崎雪恵, 谷口香, 宮石智

    第1回日本法医病理学会学術全国集会  2018.9.1 

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  • 岡山県における5歳未満の不慮の事故死の特徴

    山崎雪恵, 田宮菜奈子, 山本秀樹, 谷口香, 三浦雅布, 宮石智

    第34回日本法医学会学術中四国地方集会  2017.10.28 

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  • 認知症に基づく徘徊が関連した死亡事例の記述疫学的考察

    山崎雪恵, 井澗美希, 三浦雅布, 宮石智

    第31回日本法医学会 学術中四国地方集会  2014.11.4 

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Research Projects

  • 自宅で看取られず死亡した背景要因の解明―法医学情報による孤独死の実態把握―

    Grant number:22K21084  2022.08 - 2024.03

    日本学術振興会  科学研究費助成事業 研究活動スタート支援  研究活動スタート支援

    山崎 雪恵

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    Grant amount:\1820000 ( Direct expense: \1400000 、 Indirect expense:\420000 )

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  • 死胎児の週齢推定に関する研究~胎盤及び臍帯病理所見から法医診断へ

    Grant number:22K19648  2022.06 - 2025.03

    日本学術振興会  科学研究費助成事業 挑戦的研究(萌芽)  挑戦的研究(萌芽)

    谷口 香, 三浦 雅布, 宮石 智, 山崎 雪恵

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    Grant amount:\5200000 ( Direct expense: \4000000 、 Indirect expense:\1200000 )

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  • Immunoassay in Forensic Medicine -its Revival and Succession

    Grant number:21H03213  2021.04 - 2025.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    宮石 智, 三浦 雅布, 谷口 香, 山崎 雪恵, 高田 智世

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    Grant amount:\6500000 ( Direct expense: \5000000 、 Indirect expense:\1500000 )

    Myosin light chain (MLC)の検出による骨格筋の同定法では、当初はマイクロプレートを用いたダブルサンドイッチ法によるin-house developed ELISAとする計画であったが、ヒト心室筋MLC1を検出する臨床検査用市販試薬(キット)の応用に切り替えた。本年度の検討では、骨格筋はその部位に拘わらず十分量のMLC1を含有していることが認められた。なおこの試薬ではヒト骨格筋MLC1との交差が明らかにされており、肉眼で骨格筋を疑いうると考えられる大きさ(重量で0.01g程度)の組織片からのMLC1の定量的検出は理論計算上は可能である。また法医学実務への市販試薬の応用は、機関や人員の制限がなくなるのが利点である。
    Tear specific protein (tear prealbumin, lipocalin 1, LCN1)に着目した涙液の鑑別法では、上述のような臨床検査試薬はなく、当初計画通りマイクロプレートを用いたダブルサンドイッチELISAを採用しつつ、検査法の汎用性の観点から、ラテックス凝集法で実用に耐える検出限界を得られるかも検討対象とした。市販の標準抗原と抗体から、検査法として確立できそうな反応性のある組み合わせを検討した。また、涙液は鼻涙管経由で鼻孔から体外に排出され得ることから、鼻汁との鑑別は特に重要になる可能性に配慮し、鼻汁特異的蛋白Odorant-binding proteinに着目した鼻汁鑑別法も同時に確立する方針として、市販の標準抗原と抗体との反応性を検討した。

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  • A study on identifying unknown cause/factor of sudden infant death

    Grant number:25670343  2013.04 - 2016.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    MIYAISHI Satoru, KITAO TAKASHI, TAKATA TOMOYO, MIURA MASANOBU, TANIGUCHI KAORI, YAMASAKI YUKIE

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    Grant amount:\3640000 ( Direct expense: \2800000 、 Indirect expense:\840000 )

    Unknown factors or diseases that were not recognized to cause sudden infant death were investigated. It was thought that infection of Cronobacter sakazaki as cause of sudden death could be simply diagnosed only by the growth of that pathogen in the culture. Fulminant type Ⅰ diabetes could also be diagnosed by the extreme low level of blood 1,5-AG concentration, whereas evaluation of stress as the factor of sudden death should be examined further using saliva chromogranin A concentration.
    According to the investigation of the ratios of area of the left ventricle to those of the right ventricle and the total left heart in the heart cross-section, it was suggested that the the left heart dysfunction could be another possible unknown factor/cause of infantile sudden death.

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  • 法医学情報の公衆衛生的分析による精神障害者福祉の在り方に関する研究

    2012

    公益財団法人 岡山医学振興会 医学研究助成 

    山崎雪恵

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Class subject in charge

  • Legal Medicine (2023academic year) special  - その他

  • Practice in Legal Medicine (2023academic year) special  - その他

  • Legal Medicine (2022academic year) special  - その他

  • Practice in Legal Medicine (2022academic year) special  - その他