研究者詳細 - 佐々木　達也

論文 - 佐々木　達也

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Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke. 国際誌

Satoru Yabuno, Takao Yasuhara, Takayuki Nagase, Satoshi Kawauchi, Chiaki Sugahara, Yosuke Okazaki, Kakeru Hosomoto, Susumu Sasada, Tatsuya Sasaki, Naoki Tajiri, Cesar V Borlongan, Isao Date

Stem cell research & therapy 14 ( 1 ) 10 - 10 2023年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Mesenchymal stromal cell (MSC) transplantation therapy is a promising therapy for stroke patients. In parallel, rehabilitation with physical exercise could ameliorate stroke-induced neurological impairment. In this study, we aimed to clarify whether combination therapy of intracerebral transplantation of human modified bone marrow-derived MSCs, SB623 cells, and voluntary exercise with running wheel (RW) could exert synergistic therapeutic effects on a rat model of ischemic stroke. METHODS: Wistar rats received right transient middle cerebral artery occlusion (MCAO). Voluntary exercise (Ex) groups were trained in a cage with RW from day 7 before MCAO. SB623 cells (4.0 × 105 cells/5 μl) were stereotactically injected into the right striatum at day 1 after MCAO. Behavioral tests were performed at day 1, 7, and 14 after MCAO using the modified Neurological Severity Score (mNSS) and cylinder test. Rats were euthanized at day 15 after MCAO for mRNA level evaluation of ischemic infarct area, endogenous neurogenesis, angiogenesis, and expression of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF). The rats were randomly assigned to one of the four groups: vehicle, Ex, SB623, and SB623 + Ex groups. RESULTS: SB623 + Ex group achieved significant neurological recovery in mNSS compared to the vehicle group (p < 0.05). The cerebral infarct area of SB623 + Ex group was significantly decreased compared to those in all other groups (p < 0.05). The number of BrdU/Doublecortin (Dcx) double-positive cells in the subventricular zone (SVZ) and the dentate gyrus (DG), the laminin-positive area in the ischemic boundary zone (IBZ), and the mRNA level of BDNF and VEGF in SB623 + Ex group were significantly increased compared to those in all other groups (p < 0.05). CONCLUSIONS: This study suggests that combination therapy of intracerebral transplantation SB623 cells and voluntary exercise with RW achieves robust neurological recovery and synergistically promotes endogenous neurogenesis and angiogenesis after cerebral ischemia, possibly through a mechanism involving the up-regulation of BDNF and VEGF.

DOI： 10.1186/s13287-023-03236-4

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Continuous vagus nerve stimulation exerts beneficial effects on rats with experimentally induced Parkinson's disease: Evidence suggesting involvement of a vagal afferent pathway. 国際誌

Kakeru Hosomoto, Tatsuya Sasaki, Takao Yasuhara, Masahiro Kameda, Susumu Sasada, Ittetsu Kin, Ken Kuwahara, Satoshi Kawauchi, Yosuke Okazaki, Satoru Yabuno, Chiaki Sugahara, Koji Kawai, Takayuki Nagase, Shun Tanimoto, Cesario V Borlongan, Isao Date

Brain stimulation 16 ( 2 ) 594 - 603 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Vagus nerve stimulation (VNS) exerts neuroprotective and anti-inflammatory effects in preclinical models of central nervous system disorders, including Parkinson's disease (PD). VNS setting applied for experimental models is limited into single-time or intermittent short-duration stimulation. We developed a VNS device which could deliver continuous stimulation for rats. To date, the effects of vagal afferent- or efferent-selective stimulation on PD using continuous electrical stimulation remains to be determined. OBJECTIVE: To investigate the effects of continuous and selective stimulation of vagal afferent or efferent fiber on Parkinsonian rats. METHODS: Rats were divided into 5 group: intact VNS, afferent VNS (left VNS in the presence of left caudal vagotomy), efferent VNS (left VNS in the presence of left rostral vagotomy), sham, vagotomy. Rats underwent the implantation of cuff-electrode on left vagus nerve and 6-hydroxydopamine administration into the left striatum simultaneously. Electrical stimulation was delivered just after 6-OHDA administration and continued for 14 days. In afferent VNS and efferent VNS group, the vagus nerve was dissected at distal or proximal portion of cuff-electrode to imitate the selective stimulation of afferent or efferent vagal fiber respectively. RESULTS: Intact VNS and afferent VNS reduced the behavioral impairments in cylinder test and methamphetamine-induced rotation test, which were accompanied by reduced inflammatory glial cells in substantia nigra with the increased density of the rate limiting enzyme in locus coeruleus. In contrast, efferent VNS did not exert any therapeutic effects. CONCLUSION: Continuous VNS promoted neuroprotective and anti-inflammatory effect in experimental PD, highlighting the crucial role of the afferent vagal pathway in mediating these therapeutic outcomes.

DOI： 10.1016/j.brs.2023.03.003

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IDH-mutant Astrocytoma Arising in the Brainstem with Symptom Improvement by Foramen Magnum Decompression: A Case Report.

Takayuki Nagase, Joji Ishida, Susumu Sasada, Tatsuya Sasaki, Yoshihiro Otani, Satoru Yabuno, Kentaro Fujii, Atsuhito Uneda, Takao Yasuhara, Isao Date

NMC case report journal 10 75 - 80 2023年

記述言語：英語

Diffusely infiltrative midline gliomas are known to have a poor prognosis. The standard treatment for typical diffuse midline glioma in the pons is local radiotherapy as surgical resection is inappropriate. This case reports a brainstem glioma in which stereotactic biopsy and foramen magnum decompression were concomitantly performed to confirm the diagnosis and improve symptoms. A 23-year-old woman was referred to our department with a chief complaint of headache for six months. Magnetic resonance imaging (MRI) showed diffuse T2 hyperintense swelling of the brainstem with the pons as the main locus. Enlargement of the lateral ventricles was observed because of cerebrospinal fluid obstruction out of the posterior fossa. This was atypical for a diffuse midline glioma in terms of the longstanding slow progression of symptoms and patient age. Stereotactic biopsy was performed for diagnosis, and foramen magnum decompression (FMD) was concomitantly performed to treat the obstructive hydrocephalus. The histological diagnosis was astrocytoma, IDH-mutant. Post-surgery, the patient's symptoms were relieved, and she was discharged on the fifth day after surgery. The hydrocephalus was resolved, and the patient returned to normal life without any symptoms. The tumor size follow-up with MRI demonstrated no marked change for 12 months. Even though diffuse midline glioma is considered to have a poor prognosis, clinicians should contemplate if it is atypical. In atypical cases like the one described herein, surgical treatment may contribute to pathological diagnosis and symptom improvement.

DOI： 10.2176/jns-nmc.2022-0159

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パーキンソン病患者の脊椎と姿勢を考える招待

安原隆雄、佐々田晋、馬越通有、岡崎三保子、三好康之、佐々木達也、伊達勲

脊髄外科 SPINAL SURGERY 36 ( 3 ) 248 - 256 2022年12月

機能神経外科における感染─デバイスを用いた手術を中心に─ 招待

佐々木達也、安原隆雄、伊達勲

脳神経外科 50 ( 5 ) 1027 - 1034 2022年9月

[Infections in Functional Neurosurgery:Focusing on Device-based Surgery].

Tatsuya Sasaki, Takao Yasuhara, Isao Date

No shinkei geka. Neurological surgery 50 ( 5 ) 1027 - 1034 2022年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Functional neurosurgery for epilepsy, movement disorders, and spasticity includes some device-based surgeries such as deep brain stimulation, subdural electrode placement, vagus nerve stimulation, and baclofen pump implantation. These surgeries have a higher risk of surgical site infection(SSI)than other general neurological surgeries. Furthermore, because device removal after infection can significantly impair patients'activities of daily living and quality of life, SSI in functional neurosurgery is a worrisome surgical complication. In this study, we conducted a mini-review of the risk of infection in each device-based surgery and described associated surgical procedures and preparations performed at our institution, with a focus on infection prevention.

DOI： 10.11477/mf.1436204662

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Transplantation of modified human bone marrow-derived stromal cells affords therapeutic effects on cerebral ischemia in rats 査読国際誌

Kawauchi S, Yasuahra T, Kin K, Yabuno S, Sugahara C, Nagase T, Hosomoto K, Okazaki Y, Tomita Y, Umakoshi M, Sasaki T, Kameda M, Borlongan CV, Date I

CNS Neuroscience & Therapeutics 28 ( 12 ) 1974 - 1985 2022年8月

当院における小児のてんかん外科の手術 focal epilepsyとepileptic spasmの治療方針の決定について

佐々木達也, 細本翔, 岡崎洋介, 谷本駿, 皮居巧嗣, 佐々田晋, 安原隆雄, 土屋弘樹, 秋山倫之, 小林勝弘, 伊達勲

てんかん研究 40 ( 2 ) 401 - 401 2022年8月

当院における小児のてんかん外科の手術 focal epilepsyとepileptic spasmの治療方針の決定について

佐々木達也, 細本翔, 岡崎洋介, 谷本駿, 皮居巧嗣, 佐々田晋, 安原隆雄, 土屋弘樹, 秋山倫之, 小林勝弘, 伊達勲

てんかん研究 40 ( 2 ) 401 - 401 2022年8月

A Case of a Solitary Cortical Tuber with No Other Manifestations of Tuberous Sclerosis Complex Mimicking Focal Cortical Dysplasia Type II with Calcification.

Kakeru Hosomoto, Tatsuya Sasaki, Koji Kawai, Yosuke Okazaki, Yuki Hyodo, Takashi Shibata, Susumu Sasada, Takao Yasuhara, Katsuhiro Kobayashi, Hiroyuki Yanai, Isao Date

Acta medica Okayama 76 ( 3 ) 323 - 328 2022年6月

記述言語：英語

Cortical tubers are one of the typical intracranial manifestations of tuberous sclerosis complex (TSC). Multiple cortical tubers are easy to diagnose as TSC; however, a solitary cortical tuber without any other cutaneous or visceral organ manifestations can be confused with other conditions, particularly focal cortical dysplasia. We report a surgical case of refractory epilepsy caused by a solitary cortical tuber mimicking focal cortical dysplasia type II, and describe the radiological, electrophysiological, and histopathological findings of our case.

DOI： 10.18926/AMO/63742

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標準的な内科治療でなかなか改善しない本態性振戦─外科治療による振戦の治療─ 招待

佐々木達也、伊達勲

BRAIN and NERVE 74 ( 5 ) 645 - 651 2022年5月

[Essential Tremor That is Difficult to Improve with Standard Medical Treatment-Suppression: Surgical Treatment of Tremor].

Tatsuya Sasaki, Isao Date

Brain and nerve = Shinkei kenkyu no shinpo 74 ( 5 ) 645 - 651 2022年5月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Drug-refractory essential tremors, especially those in the upper extremities, may benefit from surgical treatment. Currently, three main treatment methods are available: deep brain stimulation (DBS), radiofrequency coagulation (RF), and magnetic resonance -guided focused ultrasound surgery (MRgFUS). DBS is a device-based therapy, and its effects are reversible, whereas RF and FUS create irreversible coagulation lesions. DBS and RF require the direct puncturing of the target, whereas FUS focuses ultrasound from extracranial sources. The primary target is the ventralis intermedius of the thalamus (Vim); however, the posterior subthalamic area (PSA) is also reportedly an effective target site. In this article, we will summarize the features of the three treatments for essential tremors, and discuss the treatment strategies and methods for each symptom.

DOI： 10.11477/mf.1416202092

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あすを創る人材育成・働き方改革定位脳手術の現在・将来の役割とスキル習得 DBS、脳生検、細胞移植、ウイルス・遺伝子療法、SEEG

佐々木達也, 細本翔, 岡崎洋介, 皮居巧嗣, 大谷理浩, 佐々田晋, 石田穣治, 藤井謙太郎, 安原隆雄, 伊達勲

日本定位・機能神経外科学会プログラム・抄録集 61回 66 - 66 2022年1月

当科におけるLeksell定位脳生検術の有用性と課題

皮居巧嗣, 佐々木達也, 岡崎洋介, 細本翔, 畝田篤仁, 大谷理浩, 石田穣治, 藤井謙太郎, 佐々田晋, 安原隆雄, 伊達勲

日本定位・機能神経外科学会プログラム・抄録集 61回 139 - 139 2022年1月

迷走神経求心路刺激・遠心路刺激のパーキンソン病モデルラットに対する有効性

細本翔, 佐々木達也, 岡崎洋介, 皮居巧嗣, 永瀬喬之, 菅原千明, 藪野諭, 河内哲, 冨田陽介, 金一徹, 桑原研, 佐々田晋, 安原隆雄, 伊達勲

日本定位・機能神経外科学会プログラム・抄録集 61回 130 - 130 2022年1月

神経症状の急激な悪化のため早急に手術し、予後良好であった非骨傷性頸椎疾患症例の検討

菅原千明, 安原隆雄, 佐々田晋, 河内哲, 藪野諭, 永瀬喬之, 佐々木達也, 伊達勲

日本脳神経外傷学会プログラム・抄録集 45回 125 - 125 2022年1月

Two Cases of Monozygotic Twins with Early-onset Isolated (DYT1) Dystonia Effectively Treated with Bilateral Globus Pallidus Internus Stimulation.

Yosuke Okazaki, Tatsuya Sasaki, Kouji Kawai, Kakeru Hosomoto, Susumu Sasada, Takao Yasuhara, Tomoyuki Akiyama, Yoshiyuki Hanaoka, Isao Date

NMC case report journal 9 307 - 312 2022年

記述言語：英語

Early-onset isolated (DYT1) dystonia is one of the most common forms of primary dystonia in childhood, and deep brain stimulation of the globus pallidus internus (GPi-DBS) is a highly effective treatment for it. However, the effectiveness of GPi-DBS in monozygotic twins with DYT1 dystonia has never been reported globally. Here, we report the cases of monozygotic twins with DYT1 dystonia who were treated using GPi-DBS, and we include a literature review. The younger brother showed an abnormal gait, with external rotation of the right lower leg at 6 years old. The symptoms gradually became so severe that he had difficulty walking on his own at 9 years of age. Treatment with levodopa-carbidopa partially resolved his symptoms, but most of the symptoms remained. Meanwhile, the older brother developed dystonia in both upper limbs at 8 years of age, with gradual symptom progression. At 13 years of age, they were diagnosed with DYT1 dystonia. Bilateral GPi-DBS was performed in both patients at 16 years of age. Their symptoms remarkably improved after surgery. The Burke-Fahn-Marsden dystonia rating scale (BFMDRS) movement score was reduced from 52 to 2 points for the younger brother and from 35 to 1 point for the older brother. Even if monozygotic twins have the same genes, the onset and severity of symptoms might vary in accordance with differences in epigenomic profiles. However, GPi-DBS treatment was very effective for the two cases; thus, we should consider the surgical interventions for each patient.

DOI： 10.2176/jns-nmc.2022-0084

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Growth Curves for Intracranial Volume and Two-dimensional Parameters for Japanese Children without Cranial Abnormality: Toward Treatment of Craniosynostosis.

Yousuke Tomita, Masahiro Kameda, Takaya Senoo, Eijiro Tokuyama, Chiaki Sugahara, Satoru Yabuno, Yosuke Okazaki, Satoshi Kawauchi, Kakeru Hosomoto, Tatsuya Sasaki, Takao Yasuhara, Isao Date

Neurologia medico-chirurgica 62 ( 2 ) 89 - 96 2021年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

In the management of patients with craniosynostosis, it is important to understand growth curve of the normal cranium. Although three-dimensional (3D) computed tomography (CT) images taken in thin slices are easily available nowadays, data on the growth curves of intracranial volume (ICV), cranial length, cranial width, and cranial height in the normal cranium are mainly based on older studies using radiography, and there are insufficient reports using CT images especially taken in thin slices. The purpose of this study was to establish growth curves in the normal cranium of Japanese children using thin-slice images. Cranial images of 106 subjects (57 males, 49 females; aged 0-83 months) without significant cranial abnormalities were retrospectively analyzed. Using thin-slice CT images, the ICV and two-dimensional parameters such as cranial length, cranial width, and cranial height were measured by iPlan, followed by generating growth curves and calculating cephalic index (CI). ICV calculated from thin-slice CT images was compared with that obtained by substituting two-dimensional parameters into Mackinnon formula. The ICV growth curves for males and females were similar in shape. As with the ICV, the two-dimensional parameters increased most rapidly in the first year after birth. There was no significant difference in CI between the sexes or among any age groups. ICV calculated from thin-slice 3D CT images was 60% of that obtained from Mackinnon formula. These data will enable us to compare these specific measurements in craniosynostosis patients directly with those of normal children, which will hopefully help in managing these patients.

DOI： 10.2176/nmc.oa.2021-0208

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Spinal Surgery after Bilateral Subthalamic Stimulation for Patients with Parkinson's Disease: A Retrospective Outcome Analysis of Pain and Functional Control.

Michiari Umakoshi, Takao Yasuhara, Jun Morimoto, Satoshi Murai, Tatsuya Sasaki, Masahiro Kameda, Kyohei Kin, Yasuyuki Miyoshi, Isao Date

Neurologia medico-chirurgica 61 ( 10 ) 607 - 618 2021年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Parkinson's disease (PD) patients often suffer from spinal diseases requiring surgeries, although the risk of complications is high. There are few reports on outcomes after spinal surgery for PD patients with deep brain stimulation (DBS). The objective of this study was to explore the data on spinal surgery for PD patients with precedent DBS. We evaluated 24 consecutive PD patients with 28 spinal surgeries from 2007 to 2017 who received at least a 2-year follow-up. The characteristics and outcomes of PD patients after spinal surgery were compared to those of 156 non-PD patients with degenerative spinal diseases treated in 2013-2017. Then, the characteristics, outcomes, and spinal alignment of PD patients receiving DBS were analyzed in degenerative spinal/lumbar diseases. The mean age at the time of spinal surgery was 68 years. The Hoehn and Yahr score regarding PD was stage 1 for 8 patients, stage 2 for 2 patients, stage 3 for 8 patients, stage 4 for 10 patients, and stage 5 for 0 patient. The median preoperative L-DOPA equivalent daily dose was 410 mg. Thirteen patients (46%) received precedent subthalamic nucleus (STN) DBS. Lumbar lesions with pain were common, and operation and anesthesia times were long in PD patients. Pain and functional improvement of PD patients persisted for 2 years after surgery with a higher complication rate than for non-PD patients. PD patients with STN DBS maintained better lumbar lordosis for 2 years after spinal surgery. STN DBS significantly maintained spinal alignment with subsequent pain and functional amelioration 2 years after surgery. The outcomes of spinal surgery for PD patients might be favorably affected by thorough treatment for PD including DBS.

DOI： 10.2176/nmc.oa.2021-0094

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DBSの刺激調整法とデバイスの特徴招待

佐々木達也、伊達勲

脳神経外科 49 ( 4 ) 829 - 837 2021年7月

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