2021/07/12 更新

写真a

アキヤマ トモユキ
秋山 倫之
AKIYAMA Tomoyuki
所属
医歯薬学域 准教授
職名
准教授

学位

  • 医学博士 ( 岡山大学 )

研究分野

  • ライフサイエンス / 胎児医学、小児成育学

  • ライフサイエンス / 神経内科学

所属学協会

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論文

  • Marked motor function improvement in a 32-year-old woman with childhood-onset hypophosphatasia by asfotase alfa therapy: Evaluation based on standardized testing batteries used in Duchenne muscular dystrophy clinical trials. 査読 国際誌

    Hitomi Nishizawa, Yoshihiko Sato, Masumi Ishikawa, Yuko Arakawa, Mari Iijima, Tomoyuki Akiyama, Kyoko Takano, Atsushi Watanabe, Tomoki Kosho

    Molecular genetics and metabolism reports   25   100643 - 100643   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Hypophosphatasia (HPP) is a rare disorder resulting from biallelic loss-of-function variants or monoallelic dominant negative variants in the ALPL gene. We herein describe the clinical outcome of a 32-year-old woman with childhood-onset HPP caused by compound heterozygous variants in ALPL. Her chief complaints were severe musculoskeletal pain, muscle weakness, and impaired daily activities necessitating assistance in housework and child-rearing in addition to a history of early tooth loss and mildly short stature. Asfotase alfa therapy produced a remarkable increase in muscle strength and daily activities and markedly reduced musculoskeletal pain. Drug efficacy was clearly demonstrated through multiple test batteries (muscle strength test using microFET®2, six-minute walking test, Stair Climb Test, rising-from-floor-time test, and number-of-steps test using Actigraph®) currently adopted as standardized evaluations in Duchenne muscular dystrophy clinical trials since no test batteries for HPP have been established to date. These tests may also be promising for the assessment of HPP.

    DOI: 10.1016/j.ymgmr.2020.100643

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  • Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. 査読 国際誌

    Tomoyuki Akiyama, Yuki Hyodo, Kosei Hasegawa, Taikan Oboshi, Katsumi Imai, Naoko Ishihara, Yuri Dowa, Takayoshi Koike, Toshiyuki Yamamoto, Jun Shibasaki, Hiroko Shimbo, Tetsuhiro Fukuyama, Kyoko Takano, Hiroshi Shiraku, Saoko Takeshita, Tohru Okanishi, Shimpei Baba, Masaya Kubota, Shin-Ichiro Hamano, Katsuhiro Kobayashi

    Pediatric neurology   113   33 - 41   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: We aimed to demonstrate the biochemical characteristics of vitamin B6-dependent epilepsy, with a particular focus on pyridoxal 5'-phosphate and pyridoxal in the cerebrospinal fluid. METHODS: Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters. We compared the biochemical characteristics of these patients with those of other epilepsy patients with low pyridoxal 5'-phosphate concentrations. RESULTS: We identified seven patients with pyridoxine-dependent epilepsy caused by an ALDH7A1 gene abnormality, two patients with pyridoxal 5'-phosphate homeostasis protein deficiency, and 28 patients with other epilepsies with low cerebrospinal fluid pyridoxal 5'-phosphate concentrations. Cerebrospinal fluid pyridoxal and pyridoxal 5'-phosphate concentrations were low in patients with vitamin B6-dependent epilepsy but cerebrospinal fluid pyridoxal concentrations were not reduced in most patients with other epilepsies with low cerebrospinal fluid pyridoxal 5'-phosphate concentrations. Increase in 3-O-methyldopa and 5-hydroxytryptophan was demonstrated in some patients with vitamin B6-dependent epilepsy, suggestive of pyridoxal 5'-phosphate deficiency in the brain. CONCLUSIONS: Low cerebrospinal fluid pyridoxal concentrations may be a better indicator of pyridoxal 5'-phosphate deficiency in the brain in vitamin B6-dependent epilepsy than low cerebrospinal fluid pyridoxal 5'-phosphate concentrations. This finding is especially helpful in individuals with suspected pyridoxal 5'-phosphate homeostasis protein deficiency, which does not have known biomarkers.

    DOI: 10.1016/j.pediatrneurol.2020.08.020

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  • Non-Gaussianity Detection of EEG Signals Based on a Multivariate Scale Mixture Model for Diagnosis of Epileptic Seizures. 査読 国際誌

    Akira Furui, Ryota Onishi, Akihito Takeuchi, Tomoyuki Akiyama, Toshio Tsuji

    IEEE transactions on bio-medical engineering   PP   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The detection of epileptic seizures from scalp electroencephalogram (EEG) signals can facilitate early diagnosis and treatment. Previous studies suggested that the Gaussianity of EEG distributions changes depending on the presence or absence of seizures; however, no general EEG signal models can explain such changes in distributions within a unified scheme. METHODS: This paper describes the formulation of a stochastic EEG model based on a multivariate scale mixture distribution that can represent changes in non-Gaussianity caused by stochastic fluctuations in EEG. In addition, we propose an EEG analysis method by combining the model with a filter bank and introduce a feature representing the non-Gaussianity latent in each EEG frequency band. RESULTS: We applied the proposed method to multichannel EEG data from twenty patients with focal epilepsy. The results showed a significant increase in the proposed feature during epileptic seizures, particularly in the high-frequency band. The feature calculated in the high-frequency band allowed highly accurate classification of seizure and non-seizure segments [area under the receiver operating characteristic curve (AUC) = 0.881] using only a simple threshold. CONCLUSION: This paper proposed a multivariate scale mixture distribution-based stochastic EEG model capable of representing non-Gaussianity associated with epileptic seizures.Experiments using simulated and real EEG data demonstrated the validity of the model and its applicability to epileptic seizure detection. SIGNIFICANCE: The stochastic fluctuations of EEG quantified by the proposed model can help detect epileptic seizures with high accuracy.

    DOI: 10.1109/TBME.2020.3006246

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  • A case of pyridoxine-dependent epilepsy with novel ALDH7A1 mutations 査読

    Yuri Dowa, Takashi Shiihara, Tomoyuki Akiyama, Kosei HASEGAWA, Fumitaka Inoue, Mio Watanabe

    Oxford Medical Case Reports   3   99 - 103   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    <jats:title>Abstract</jats:title>
    <jats:p>Pyridoxine-dependent epilepsy (PDE) is a rare autosomal-recessive disorder typically presenting with neonatal seizures and is sometimes difficult to diagnose, because the clinical features mimic those of birth asphyxia. A Japanese newborn boy presented with pulmonary haemorrhage and convulsions on the day of birth. Brain computed tomography showed diffuse, but mild, low-density cerebral white matter and a thin subdural hematoma in the posterior fossa. He did not have thrombocytopenia or coagulopathy. His respiratory status improved with conservative treatment, but his convulsions were persistent even after prescription of several antiepileptic drugs. His serum and cerebrospinal fluid showed decreased vitamin B6 vitamers and increased upstream metabolites of α-aminoadipic semialdehyde dehydrogenase, strongly suggesting a diagnosis of PDE; the epileptic spasms ceased after administration of intravenous pyridoxal phosphate hydrate. Gene analysis revealed novel compound heterozygous mutations in ALDH7A1 that included NM_001182.4:[c.1196G &amp;gt; T] and [c.1200 + 1G &amp;gt; A]. Atypical birth asphyxia with persistent neonatal seizure should prompt vitamin B6/metabolite screening.</jats:p>

    DOI: 10.1093/omcr/omaa008

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  • Laboratory changes during ACTH therapy associated with renal calcified lesions. 査読 国際誌

    Hiroyuki Miyahara, Tomoyuki Akiyama, Kosei Hasegawa, Mari Akiyama, Makio Oka, Katsuhiro Kobayashi, Hirokazu Tsukahara

    Pediatrics international : official journal of the Japan Pediatric Society   2020年1月

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    記述言語:英語  

    BACKGROUND: Renal calcified lesions are known as one of the complications during adrenocorticotropic hormone (ACTH) therapy for intractable epilepsy. However, laboratory changes during the therapy or laboratory features of high-risk cases with renal calcified lesions are yet to be clarified. METHODS: In this study, 43 patients with West syndrome ≤2 years were included. We retrospectively reviewed age and body mass index at the beginning of ACTH therapy, as well as the amount of fluid intake, daily urinary volume, and laboratory data during therapy. In addition, we studied the urinary sediment of the cases with renal calcified lesions diagnosed by computed tomography. RESULTS: After initiating ACTH treatment, urinary calcium (Ca)/creatinine ratio and urinary pH increased within 2 weeks. Urinary crystals and renal tubular epithelial cells (RTECs) in urinary sediment were frequently found in most cases. Urinary Ca levels, proteinuria or frequency of urinary crystals, and number of RTECs in the urinary sediment were significantly higher in patients with epithelial casts (ECs) or hematuria than in patients without these findings. Among the 7 patients who underwent abdominal CT, ECs or hematuria were found only those with renal calcified lesions. These findings suggested that patients with ECs or hematuria were more likely to have calcified lesions. CONCLUSIONS: The risk of renal calcified lesions increases after 2 weeks of ACTH treatment. Abnormal findings in urinary sediments might be an early sign of renal calcification during ACTH therapy.

    DOI: 10.1111/ped.14158

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  • Clinical and genetic aspects of mild hypophosphatasia in Japanese patients. 査読 国際誌

    Katsuyuki Yokoi, Yoko Nakajima, Yasuko Shinkai, Yoshimi Sano, Mototaka Imamura, Tomoyuki Akiyama, Tetsushi Yoshikawa, Tetsuya Ito, Hiroki Kurahashi

    Molecular genetics and metabolism reports   21   100515 - 100515   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Hypophosphatasia (HPP) is a rare inborn error of metabolism that results from a dysfunctional tissue non-specific alkaline phosphatase enzyme (TNSALP). Although genotype-phenotype correlations have been described in HPP patients, only sparse information is currently available on the genetics of mild type HPP. Methods: We investigated 5 Japanese patients from 3 families with mild HPP (patients 1 and 2 are siblings; patient 4 is a daughter of patient 5) who were referred to Fujita Health University due to the premature loss of deciduous teeth. Physical and dental examinations, and blood, urine and bone density tests were conducted. Genetic analysis of the ALPL gene was performed in all patients with their informed consent. Results: After a detailed interview and examination, we found characteristic symptoms of HPP in some of the study cases. Mobile teeth or the loss of permanent teeth were observed in 2 patients, and 3 out of 5 patients had a history of asthma. The serum ALP levels of all patients were 30% below the lower limit of the age equivalent normal range. ALPL gene analysis revealed compound heterozygous mutations, including Ile395Val and Leu520Argfs in family 1, Val95Met and Gly491Arg in family 2, and a dominant missense mutation (Gly456Arg) in family 3. The 3D-modeling of human TNSALP revealed three mutations (Val95Met, Ile395Val and Gly456Arg) at the homodimer interface. Severe collisions between the side chains were predicted for the Gly456Arg variant. Discussion: One of the characteristic findings of this present study was a high prevalence of coexisting asthma and a high level serum IgE level. These characteristics may account for the fragility of tracheal tissues and a predisposition to asthma in patients with mild HPP. The genotypes of the five mild HPP patients in our present study series included 1) compound heterozygous for severe and hypomorphic mutations, and 2) dominant-negative mutations. All of these mutations were at the homodimer interface, but only the dominant-negative mutation was predicted to cause a severe collision effect between the side chains. This may account for varying mechanisms leading to different effects on TNSALP function.

    DOI: 10.1016/j.ymgmr.2019.100515

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  • Genomic backgrounds of Japanese patients with undiagnosed neurodevelopmental disorders. 査読 国際誌

    Toshiyuki Yamamoto, Taichi Imaizumi, Keiko Yamamoto-Shimojima, Yongping Lu, Tomoe Yanagishita, Shino Shimada, Pin Fee Chong, Ryutaro Kira, Riyo Ueda, Akihiko Ishiyama, Eri Takeshita, Ken Momosaki, Shiro Ozasa, Tomoyuki Akiyama, Katsuhiro Kobayashi, Hiroo Oomatsu, Hikaru Kitahara, Tokito Yamaguchi, Katsumi Imai, Hirokazu Kurahashi, Akihisa Okumura, Hirokazu Oguni, Toshiyuki Seto, Nobuhiko Okamoto

    Brain & development   41 ( 9 )   776 - 782   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Recently, many genes related to neurodevelopmental disorders have been identified by high-throughput genomic analysis; however, a comprehensive understanding of the mechanism underlying neurodevelopmental disorders remains to be established. To further understand these underlying mechanisms, we performed a comprehensive genomic analysis of patients with undiagnosed neurodevelopmental disorders. METHODS: Genomic analysis using next-generation sequencing with a targeted panel was performed for a total of 133 Japanese patients (male/female, 81/52) with previously undiagnosed neurodevelopmental disorders, including developmental delay (DD), intellectual disability (ID), autism spectrum disorder (ASD), and epilepsy. Genomic copy numbers were also analyzed using the eXome Hidden Markov Model (XHMM). RESULTS: Thirty-nine patients (29.3%) exhibited pathogenic or likely pathogenic findings with single-gene variants or chromosomal aberrations. Among them, 20 patients were presented here. Pathogenic or likely pathogenic variants were identified in 18 genes, including ACTG1, CACNA1A, CHD2, CDKL5, DNMT3A, EHMT1, GABRB3, GABRG2, GRIN2B, KCNQ3, KDM5C, MED13L, SCN2A, SHANK3, SMARCA2, STXBP1, SYNGAP1, and TBL1XR1. CONCLUSION: A diagnostic yield of 29.3% in this study was nearly the same as that previously reported from other countries. Thus, we suggest that there is no difference in genomic backgrounds in Japanese patients with undiagnosed neurodevelopmental disabilities. Although most of the patients possessed de novo variants, one of the patients showed an X-linked inheritance pattern. As X-linked recessive disorders exhibit the possibility of recurrent occurrence in the family, comprehensive molecular diagnosis is important for genetic counseling.

    DOI: 10.1016/j.braindev.2019.05.007

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  • High-frequency oscillations in a spectrum of pediatric epilepsies characterized by sleep-activated spikes in scalp EEG. 査読

    Ohuchi Y, Akiyama T, Matsuhashi M, Kobayashi K

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology   130 ( 10 )   1971 - 1980   2019年10月

  • The Effect of S-Adenosylmethionine Treatment on Neurobehavioral Phenotypes in Lesch-Nyhan Disease: A Case Report. 査読

    Momosaki K, Kido J, Matsumoto S, Taniguchi A, Akiyama T, Sawada T, Ozasa S, Nakamura K

    Case reports in neurology   11 ( 3 )   256 - 264   2019年9月

  • Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy. 査読 国際誌

    Tomonori Ishiguro, Yuichiro Sugiyama, Kazuto Ueda, Yukako Muramatsu, Hiroyuki Tsuda, Tomomi Kotani, Toshimi Michigami, Kanako Tachikawa, Tomoyuki Akiyama, Masahiro Hayakawa

    Brain & development   41 ( 8 )   721 - 725   2019年9月

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    記述言語:英語  

    Hypophosphatasia (HPP) is a rare disorder caused by low serum tissue non-specific alkaline phosphatase (ALP) activity due to hypomorphic mutations in the ALPL gene. HPP is characterized by defective bone mineralization. It frequently accompanies pyridoxine-responsive seizures. Because alkaline phosphatase change pyridoxal 5' phosphate (PLP) into pyridoxal (PL), which can cross the blood brain barrier and regulates inhibitory neurotransmitter gamma-aminobutyric acid. The female patient was born at a gestational age of 37 weeks 2 days. She presented severe respiratory disorder due to extreme thoracic hypoplasia. With the extremely low serum ALP value (14 IU/L), she was clinically diagnosed as HPP. The diagnosis was confirmed with genetic testing. On day1, the subclinical seizures were detected by aEEG. Together with enzyme replacement therapy by asfotase alfa, pyridoxine hydrochloride was administered, then the seizures were rapidly controlled. While confirming that there was no seizure by aEEG monitoring, pyridoxine hydrochloride was gradually discontinued after 1 month. Before administration of pyridoxine hydrochloride, PL was extremely low (4.7 nM) and PLP was increased (1083 nM). After the withdrawal, PL was increased to 84.9 nM only by enzyme replacement. Monitoring with aEEG enabled early intervention for pyridoxine responsive seizures. Confirming increased serum PL concentration is a prudent step in determining when to reduce or discontinue pyridoxine hydrochloride during enzyme replacement therapy.

    DOI: 10.1016/j.braindev.2019.03.015

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  • Action of antiepileptic drugs on neurons. 査読

    Kobayashi K, Endoh F, Ohmori I, Akiyama T

    Brain & development   2019年7月

  • A case of dihydropyrimidinase deficiency incidentally detected by urine metabolome analysis. 査読 国際誌

    Hiroki Tsuchiya, Tomoyuki Akiyama, Tomiko Kuhara, Yoko Nakajima, Morimasa Ohse, Hiroki Kurahashi, Takema Kato, Yasuhiro Maeda, Harumi Yoshinaga, Katsuhiro Kobayashi

    Brain & development   41 ( 3 )   280 - 284   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Dihydropyrimidinase deficiency is a rare autosomal recessive disease affecting the second step of pyrimidine degradation. It is caused by mutations in the DPYS gene. Only approximately 30 cases have been reported to date, with a phenotypical variability ranging from asymptomatic to severe neurological illness. We report a case of dihydropyrimidinase deficiency incidentally detected by urine metabolome analysis. Gas chromatography-mass spectrometry-based urine metabolomics demonstrated significant elevations of dihydrouracil and dihydrothymine, which were subsequently confirmed by a quantitative analysis using liquid chromatography-tandem mass spectrometry. Genetic testing of the DPYS gene revealed two mutations: a novel mutation (c.175G > T) and a previously reported mutation (c.1469G > A). Dihydropyrimidinase deficiency is probably underdiagnosed, considering its wide phenotypical variability, nonspecific neurological presentations, and an estimated prevalence of 2/20,000. As severe 5-fluorouracil-associated toxicity has been reported in patients and carriers of congenital pyrimidine metabolic disorders, urinary pyrimidine analysis should be considered for those who will undergo 5-fluorouracil treatment.

    DOI: 10.1016/j.braindev.2018.10.005

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  • Pyridoxal 5'-phosphate and related metabolites in hypophosphatasia: Effects of enzyme replacement therapy. 査読 国際誌

    Tomoyuki Akiyama, Takuo Kubota, Keiichi Ozono, Toshimi Michigami, Daisuke Kobayashi, Shinji Takeyari, Yuichiro Sugiyama, Masahiro Noda, Daisuke Harada, Noriyuki Namba, Atsushi Suzuki, Maiko Utoyama, Sachiko Kitanaka, Mitsugu Uematsu, Yusuke Mitani, Kunihiro Matsunami, Shigeru Takishima, Erika Ogawa, Katsuhiro Kobayashi

    Molecular genetics and metabolism   125 ( 1-2 )   174 - 180   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To investigate the utility of serum pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) as a diagnostic marker of hypophosphatasia (HPP) and an indicator of the effect of, and patient compliance with, enzyme replacement therapy (ERT), we measured PLP, PL, and PA concentrations in serum samples from HPP patients with and without ERT. METHODS: Blood samples were collected from HPP patients and serum was frozen as soon as possible (mostly within one hour). PLP, PL, and PA concentrations were analyzed using high-performance liquid chromatography with fluorescence detection after pre-column derivatization by semicarbazide. We investigated which metabolites are associated with clinical phenotypes and how these metabolites change with ERT. RESULTS: Serum samples from 20 HPP patients were analyzed. The PLP-to-PL ratio and PLP concentration were elevated in all HPP patients. They correlated negatively with serum alkaline phosphatase (ALP) activity and showed higher values in more severe phenotypes (perinatal severe and infantile HPP) compared with other phenotypes. PL concentration was reduced only in perinatal severe HPP. ERT reduced the PLP-to-PL ratio to mildly reduced or low-normal levels and the PLP concentration was reduced to normal or mildly elevated levels. Urine phosphoethanolamine (PEA) concentration did not return to normal levels with ERT in most patients. CONCLUSIONS: The serum PLP-to-PL ratio is a better indicator of the effect of ERT for HPP than serum PLP and urine PEA concentrations, and a PLP-to-PL ratio of <4.0 is a good indicator of the effect of, and patient compliance with, ERT.

    DOI: 10.1016/j.ymgme.2018.07.006

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  • Detection of fast (40-150 Hz) oscillations from the ictal scalp EEG data of myoclonic seizures in pediatric patients. 査読

    Kobayashi K, Ohuchi Y, Shibata T, Hanaoka Y, Akiyama M, Oka M, Endoh F, Akiyama T

    Brain & development   40 ( 5 )   397 - 405   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.braindev.2018.01.004

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  • Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate 査読

    Yasushi Iimura, Kevin Jones, Lynne Takada, Itsuki Shimizu, Misaki Koyama, Kyoko Hattori, Yushi Okazawa, Yutaka Nonoda, Eishi Asano, Tomoyuki Akiyama, Cristina Go, Ayako Ochi, O. Carter Snead, Elizabeth J. Donner, James T. Rutka, James M. Drake, Hiroshi Otsubo

    Epilepsia   59 ( 3 )   544 - 554   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing Inc.  

    Objective: Epileptic spasms (ES) often become drug-resistant. To reveal the electrophysiological difference between children with ES (ES+) and without ES (ES−), we compared the occurrence rate (OR) of high-frequency oscillations (HFOs) and the modulation index (MI) of coupling between slow and fast oscillations. In ES+, we hypothesized that (1) pathological HFOs are more widely distributed and (2) slow oscillations show stronger coupling with pathological HFOs than in ES−. Methods: We retrospectively reviewed 24 children with drug-resistant multilobar onset epilepsy, who underwent intracranial video electroencephalography prior to multilobar resections. We measured the OR of HFOs and determined the electrodes with a high rate of HFOs by cluster analysis. We calculated MI, which reflects the degree of coupling between HFO (ripple/fast ripple [FR]) amplitude and 5 different frequency bands of delta and theta activities (0.5-1 Hz, 1-2 Hz, 2-3 Hz, 3-4 Hz, 4-8 Hz). Results: In ES+ (n = 10), the OR( FR s), the number of electrodes with high-rate FRs, and the MI( FR s &amp
    3-4 Hz) in all electrodes were significantly higher than in ES− (n = 14). In both the ES+ and ES− groups, MI(ripples/ FR s &amp
    3-4 Hz) was the highest among the 5 frequency bands. Within the good seizure outcome group, the OR( FR s) and the MI( FR s &amp
    3-4 Hz) in the resected area in ES+ were significantly higher than in ES− (OR[FR s], P =.04
    MI[ FR s &amp
    3-4 Hz], P =.04). Significance: In ES+, the larger number of high-rate FR electrodes indicates more widespread epileptogenicity than in ES−. High values of OR( FR s) and MI( FR s &amp
    3-4 Hz) in ES+ compared to ES− are a signature of the severity of epileptogenicity. We proved that ES+ children who achieved seizure freedom following multilobar resections exhibited strong coupling between slow oscillations and FRs.

    DOI: 10.1111/epi.13995

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  • A case of perinatal hypophosphatasia with a novel mutation in the <i>ALPL</i> gene: clinical course and review of the literature. 査読

    Oyachi M, Harada D, Sakamoto N, Ueyama K, Kondo K, Kishimoto K, Izui M, Nagamatsu Y, Kashiwagi H, Yamamuro M, Tamura M, Kikuchi S, Akiyama T, Michigami T, Seino Y, Namba N

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology   27 ( 3 )   179 - 186   2018年

  • Differential diagnosis of nonepileptic twilight state with convulsive manifestations after febrile seizures 査読

    Hiroyuki Miyahara, Tomoyuki Akiyama, Kenji Waki, Yoshio Arakaki

    Brain and Development   40 ( 9 )   781 - 785   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier B.V.  

    Background: Nonepileptic twilight state with convulsive manifestations (NETC) is a nonepileptic state following a febrile seizure (FS), which may be misdiagnosed as a prolonged seizure and result in overtreatment. We aimed to describe clinical manifestations of NETC and to determine characteristics that are helpful to distinguish NETC from other pathological conditions. Methods: We conducted a retrospective chart review from January 2010 to December 2016 and selected the patients who presented with symptoms resembling status epilepticus with fever and a confirmed diagnosis using an electroencephalogram (EEG). We compared the NETC clinical features and venous blood gas analysis results with those of other conditions that mimic NETC. We also compared the characteristics of NETC with past reports. Results: Our NETC patients presented with short durations of the preceding generalized convulsions followed by tonic posturing, closed eyes, no cyanosis, responsiveness to painful stimulation, and no accumulation of CO2 in the venous blood gas. Most of these characteristics were consistent with past reports. Prolonged FS or acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) showed several of these features, but all the characteristics were not consistent with our study. Conclusions: Prolonged FS and AESD need to be differentiated from NETC, and close clinical observation makes it possible to partially distinguish NETC from the other conditions. EEG is recommended for patients with symptoms that are inconsistent with these features.

    DOI: 10.1016/j.braindev.2018.05.014

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  • Pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children 査読

    Tomoyuki Akiyama, Yumiko Hayashi, Yoshiyuki Hanaoka, Takashi Shibata, Mari Akiyama, Hiroki Tsuchiya, Tokito Yamaguchi, Katsuhiro Kobayashi

    CLINICA CHIMICA ACTA   472   118 - 122   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Background We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in paired serum and cerebrospinal fluid (CSF) samples from children and investigated the effect of age on the concentrations and CSF-to-serum ratios of these vitamers.
    Methods: Serum and CSF samples prospectively collected from 49 pediatric patients were analyzed. PLP, PL, and PA were measured using high-performance liquid chromatography with fluorescence detection, using pre column derivatization by semicarbazide. Effects of age on these vitamers, the PLP-to-PL ratio, CSF-to-serum PLP ratio, and CSF-to-serum PL ratio were evaluated using correlation analysis.
    Results: The PLP, PL, and PA concentrations in the serum and CSF were higher at younger ages, except for CSF PA concentrations that were mostly below the limit of detection (&lt; 1.2 nmo1/1). The PLP-to-PL ratios in the serum and CSF correlated positively with age. The CSF-to-serum PLP ratio and CSF-to-serum PL ratio were independent of age.
    Conclusions: Age-related changes in PLP, PL, and PA in serum and in CSF from pediatric patients and CSF-toserum ratios of PLP and PL demonstrated in this study will provide valuable information for evaluating PLP supply to the central nervous system from the peripheral blood.

    DOI: 10.1016/j.cca.2017.07.032

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  • Epileptogenic high-frequency oscillations skip the motor area in children with multilobar drug-resistant epilepsy 査読

    Yasushi Iimura, Kevin Jones, Kyoko Hattori, Yushi Okazawa, Atsuko Noda, Kana Hoashi, Yutaka Nonoda, Eishi Asano, Tomoyuki Akiyama, Cristina Go, Ayako Ochi, O. Carter Snead, Elizabeth J. Donner, James T. Rutka, James M. Drake, Hiroshi Otsubo

    CLINICAL NEUROPHYSIOLOGY   128 ( 7 )   1197 - 1205   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: Subtotal hemispherectomy involves the resection of multiple lobes in children with drug-resistant epilepsy, skipping the motor area (MA). We determined epileptogenicity using the occurrence rate (OR) of high-frequency oscillations (HFOs) and the modulation index (MI), demonstrating strength of coupling between HFO and slow wave. We hypothesized that epileptogenicity increased over the multiple lobes but skipped the MA.
    Methods: We analyzed 23 children (14 subtotal hemispherectomy; 9 multilobar resections). Scalp video-EEG and magnetoencephalography were performed before surgery. We analyzed the OR(HFO) and MI(5 (phases= 0.5-8) (Hz)) on electrodes of total area, resection areas, and MA. We compared the data between good [International League Against Epilepsy (ILAE) class I-II] and poor (III-VI) seizure outcome groups.
    Results: ILAE class Ia outcome was achieved in 18 children. Among the MI(5 phases) in the resection areas, MI(3-4 (Hz)) was the highest. The OR(HFO) and MI(3-4 (Hz)) in both total area and resection areas were significantly higher in the good seizure outcome group than in the poor outcome group. The OR(HFO) and MI(3-4 (Hz)) in resection areas were significantly higher than in the MA.
    Conclusions: Our patients with multilobar drug-resistant epilepsy showed evidence of multifocal epileptogenicity that specifically skipped the MA. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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  • Complex observation of scalp fast (40-150 Hz) oscillations in West syndrome and related disorders with structural brain pathology. 査読

    Kobayashi K, Endoh F, Agari T, Akiyama T, Akiyama M, Hayashi Y, Shibata T, Hanaoka Y, Oka M, Yoshinaga H, Date I

    Epilepsia open   2 ( 2 )   260 - 266   2017年6月

  • Measurement of pyridoxal 5 '-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children 査読

    Tomoyuki Akiyama, Mari Akiyama, Yumiko Hayashi, Takashi Shibata, Yoshiyuki Hanaoka, Soichiro Toda, Katsumi Imai, Shin-ichiro Hamano, Tohru Okanishi, Harumi Yoshinaga, Katsuhiro Kobayashi

    CLINICA CHIMICA ACTA   466   1 - 5   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Background: We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in the cerebrospinal fluid (CSF) of children and to investigate the effect of age, sex, epilepsy, and anti-epileptic drug (AED) therapy on these vitamers.
    Methods: CSF samples prospectively collected from 116 pediatric patients were analyzed. PLP, PI, and PA were measured using high-performance liquid chromatography with fluorescence detection, using pre-column derivatization by semicarbazide. Effects of age, sex, epilepsy, and AEDs on these vitamers and the PLP/PL ratio were evaluated using multiple linear regression models.
    Results: The PLP, PL, and PA concentrations were correlated negatively with age and the PLP/PL ratio was correlated positively with age. Multiple regression analysis revealed that the presence of epilepsy was associated with lower PLP concentrations and PLP/PL ratios but sex and AED therapy had no influence on these values. The observed ranges of these vitamers in epileptic and non-epileptic patients were demonstrated.
    Conclusions: We showed the age dependence of PLP and PL in CSF from pediatric patients. Epileptic patients had lower PLP concentrations and PLP/PL ratios than non-epileptic patients, but it is unknown whether this is the cause, or a result, of epilepsy. (C) 2016 Elsevier B.V. All rights reserved.

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  • Severe leukoencephalopathy with cortical involvement and peripheral neuropathy due to FOLR1 deficiency 査読

    Yu Kobayashi, Jun Tohyama, Tomoyuki Akiyama, Shinichi Magara, Hideshi Kawashima, Noriyuki Akasaka, Mitsuko Nakashima, Hirotomo Saitsu, Naomichi Matsumoto

    BRAIN & DEVELOPMENT   39 ( 3 )   266 - 270   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Cerebral folate deficiency due to folate receptor 1 gene (FOLR1) mutations is an autosomal recessive disorder resulting from a brain-specific folate transport defect. It is characterized by late infantile onset, severe psychomotor regression, epilepsy, and leukodystrophy. We describe a consanguineous girl exhibiting severe developmental regression, intractable epilepsy, polyneuropathy, and profound hypomyelination with cortical involvement. Magnetic resonance imaging showed cortical disturbances in addition to profound hypomyelination and cerebellar atrophy. Nerve conduction studies revealed both axonal degeneration and demyelinating features. A diagnosis of cerebral folate deficiency was confirmed by a homozygous c.466T&gt;G (p.W156G) mutation in FOLR1, coupled with extremely low cerebrospinal fluid levels of 5-methyltetrahydrofolate. Her symptoms, neuroradiological findings, and polyneuropathy were alleviated by oral folinic acid treatment in conjunction with intravenous and intramuscular administration therapy. Our patient shows that folinic acid therapy can ameliorate the clinical symptoms, white matter disturbances, cortical insults, and peripheral neuropathy of cerebral folate deficiency caused by FOLR1 mutation. It is important to recognize these clinical symptoms and make a precise diagnosis early on, because cerebral folate deficiency is treatable. (C) 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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  • Simultaneous measurement of monoamine metabolites and 5-methyltetrahydrofolate in the cerebrospinal fluid of children. 査読

    Akiyama Tomoyuki, Hayashi Yumiko, Hanaoka Yoshiyuki, Shibata Takashi, Akiyama Mari, Nakamura Kazuyuki, Tsuyusaki Yu, Kubota Masaya, Yoshinaga Harumi, Kobayashi Katsuhiro

    Clin Chim Acta   465   5 - 10   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: We describe a new method for simultaneous measurement of monoamine metabolites (3-O-methyldopa [3-OMD], 3-methoxy-4-hydroxyphenylethyleneglycol [MHPG], 5-hydroxyindoleacetic acid [5-HIAA], and homovanillic acid [HVA]) and 5-methyltetrahydrofolate (5-MTHF) and its use on cerebrospinal fluid (CSF) samples from pediatric patients. METHODS: Monoamine metabolites and 5-MTHF were measured by high-performance liquid chromatography with fluorescence detection. CSF samples were prospectively collected from children according to a standardized collection protocol in which the first 1-ml fraction was used for analysis. RESULTS: Monoamine metabolites and 5-MTHF were separated within 10min. They showed linearity from the limit of detection to 1024nmol/l. The limit of quantification of each metabolite was sufficiently low for the CSF sample assay. In 42 CSF samples after excluding cases with possibly altered neurotransmitter profiles, the concentrations of 3-OMD, MHPG, 5-HIAA, HVA, and 5-MTHF showed significant age dependence and their ranges were comparable with the reference values in the literature. The metabolite profiles of aromatic l-amino acid decarboxylase deficiency, Segaw

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  • Simultaneous measurement of monoamine metabolites and 5-methyltetrahydrofolate in the cerebrospinal fluid of children 査読

    Tomoyuki Akiyama, Yumiko Hayashi, Yoshiyuki Hanaoka, Takashi Shibata, Mari Akiyama, Kazuyuki Nakamura, Yu Tsuyusaki, Masaya Kubota, Harumi Yoshinaga, Katsuhiro Kobayashi

    CLINICA CHIMICA ACTA   465   5 - 10   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Background: We describe a new method for simultaneous measurement of monoamine metabolites (3-0-methyldopa [3-0MD],3-methoxy-4-hydroxyphenylethyleneglycol [MHPG], 5-hydroxyindoleacetic acid [5-HIAA], and homovanillic acid [HVA]) and 5-methyltetrahydrofolate (5-MTHF) and its use on cerebrospinal fluid (CSF) samples from pediatric patients.
    Methods: Monoamine metabolites and 5-MTHF were measured by high-performance liquid chromatography with fluorescence detection. CSF samples were prospectively collected from children according to a standardized collection protocol in which the first 1-ml fraction was used for analysis.
    Results: Monoamine metabolites and 5-MTHF were separated within 10 min. They showed linearity from the limit of detection to 1024 nmol/l. The limit of quantification of each metabolite was sufficiently low for the CSF sample assay. In 42 CSF samples after excluding cases with possibly altered neurotransmitter profiles, the concentrations of 3-OMD, MHPG, 5-HIAA, HVA, and 5-MTHF showed significant age dependence and their ranges were comparable with the reference values in the literature. The metabolite profiles of aromatic L-amino acid decarboxylase deficiency, Segawa disease, and folate receptor alpha defect by this method were compatible with those in the literature.
    Conclusions: This method is a simple means of measuring CSF monoamine metabolites and 5-MTHF, and is especially useful for laboratories not equipped with electrochemical detectors. (C) 2016 Elsevier B.V. All rights reserved.

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  • A Japanese case of β-ureidopropionase deficiency with dysmorphic features. 査読

    Akiyama T, Shibata T, Yoshinaga H, Kuhara T, Nakajima Y, Kato T, Maeda Y, Ohse M, Oka M, Kageyama M, Kobayashi K

    Brain & development   39 ( 1 )   58 - 61   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.braindev.2016.08.001

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  • Importance of the multisystem follow-up in patients with tuberous sclerosis complex. 査読

    Yoshinaga H, Oka M, Akiyama T, Endoh F, Akiyama M, Hayashi Y, Shibata T, Hanaoka Y, Kobayashi K

    No to hattatsu = Brain and development   5-9   5 - 9   2017年1月

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  • Significance of High-frequency Electrical Brain Activity 査読

    Katsuhiro Kobayashi, Tomoyuki Akiyama, Takashi Agari, Tatsuya Sasaki, Takashi Shibata, Yoshiyuki Hanaoka, Mari Akiyama, Fumika Endoh, Makio Oka, Isao Date

    ACTA MEDICA OKAYAMA   71 ( 3 )   191 - 200   2017年

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (&lt;0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and &gt;200/250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological/epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs/FOs is rapidly expanding.

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  • A study on spike focus dependence of high-frequency activity in idiopathic focal epilepsy in childhood. 査読

    Shibata T, Yoshinaga H, Akiyama T, Kobayashi K

    Epilepsia open   1 ( 3-4 )   121 - 129   2016年12月

  • Fast (40-150 Hz) oscillations are associated with positive slow waves in the ictal EEGs of epileptic spasms in West syndrome 査読

    Katsuhiro Kobayashi, Tomoyuki Akiyama, Makio Oka, Fumika Endoh, Harumi Yoshinaga

    BRAIN & DEVELOPMENT   38 ( 10 )   909 - 914   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Objective: To elucidate the generative mechanisms of epileptic spasms (ESs) in West syndrome, we investigated the temporal relationship between scalp fast (40-150 Hz) oscillations (FOs) and slow waves in the ictal electroencephalograms (EEGs) of ESs.
    Methods: In 11 infants with WS, ictal FOs were detected in a bipolar montage based on spectral and waveform criteria. Their temporal distribution was analyzed in terms of the positive peaks (trough point, TT) of identical EEG data in a referential montage. Among six EEG data sections defined according to TT, the number of FOs, peak power values, and peak frequencies were compared.
    Results: We identified a total of 1014 FOs (946 gamma and 68 ripple oscillations), which clustered closely at TT. The number of gamma oscillations in the 1 s epoch including TT was significantly higher than those in the prior and subsequent phases. Peak power values and frequencies tended to be higher in these positive phase sections.
    Conclusions: The temporal association of FO clustering and positive slow waves in the ictal EEGs of ES indicated that active neuronal firing related to FOs underlies the generation of ESs and their ictal slow waves. (C) 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights

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  • Magnetoencephalography spike sources interrelate the extensive epileptogenic zone of tuberous sclerosis complex 査読

    Tohru Okanishi, Tomoyuk Akiyama, Ellen Mayo, Yasunori Honda, Chihiro Ueda-Kawada, Midori Nakajima, Yoichiro Homma, Ayako Ochi, Cristina Go, Elysa Widjaja, Sylvester H. Chuang, James T. Rutka, James Drake, O. Carter Snead, Hiroshi Otsubo

    EPILEPSY RESEARCH   127   302 - 310   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Objective: We hypothesized that the extensive epileptic network in patients with tuberous sclerosis complex (TSC) manifests as clustered and scattered distributions of magnetoencephalography spike sources (MEGSS).
    Methods: We retrospectively analyzed pre-surgical MEG in 15 patients with TSC. We performed single moving dipole analysis to localize and classify clustered and scattered MEGSS. We compared the number of electrodes within the resected area (RA) and the proportions of clustered and scattered MEGSS within RA with the seizure outcome.
    Results: The number of electrodes within RA ranged from 29 to 83 (mean = 51). The MEGSS were distributed over multiple lobes (3-8; mean = 5.9) and bilaterally in 14 patients. Clusters of MEGSS ranged from 1 to 4 (mean = 1.4). The number of MEGSS ranged in total from 28 to 139 (mean = 70); in the clusters, 10-128 (mean = 49); and in the scatters, 0-45 (mean = 21). Four patients achieved an Engel class I surgical outcome, four, a class II outcome; five, a class III outcome; and two, a class IV outcome. The proportion of MEGSS ranged in total from 0 to 92% (mean = 57%) within RA; 0-100% (mean = 67%) in the resection hemisphere; 0-100% (mean = 63%) in the clusters; and 0-81% (mean = 28%) in the scatters. Univariate ordinal logistic regression analyses showed that the proportion of scattered MEGSS within RA (p = 0.049) significantly correlated with seizure outcomes. Multivariate analyses using three covariates (number of electrodes, proportions of clustered and scattered MEGSS within RA) showed that only the proportion of scattered MEGSS within RA significantly correlated with seizure outcomes (p = 0.016).
    Significance: MEG data showed a wide distribution of multilobar MEGSS in patients with TSC. The seizure outcome was not related to the clustered MEGSS within RA, since the grids were essentially planned to cover and resect the clustered MEGSS surrounding tubers. The maximal possible resection of scattered MEGSS correlated with improved seizure outcome in TSC. Some parts of the epileptogenic zone disrupted by multiple tubers did not have a sufficiently large area to produce clustered MEGSS. Although the wide distribution of scattered MEGSS is not interpreted as epileptogenic, they might be interrelated with clustered MEGSS to project a complex epilepsy network and be part of the extensive epileptogenic zones found in TSC. (C) 2016 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.eplepsyres.2016.09.007

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  • SSADH deficiency possibly associated with enzyme activity-reducing SNPs 査読

    Tomoyuki Akiyama, Hitoshi Osaka, Hiroko Shimbo, Tomiko Kuhara, Takashi Shibata, Katsuhiro Kobayashi, Kenji Kurosawa, Harumi Yoshinaga

    BRAIN & DEVELOPMENT   38 ( 9 )   871 - 874   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Background: Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare autosomal recessive disorder that affects the degradation of gamma-aminobutyric acid and leads to the accumulation of gamma-hydroxybutyric acid (GHB) in body fluids. Diagnosis of SSADH deficiency is challenging, since the neurological symptoms are non-specific.
    Case: The patient is a nine-year-old Japanese boy who presented with developmental delay, autism, epilepsy, and episodic gait disturbance. Brain magnetic resonance imaging showed hyperintense lesions in the bilateral thalami, globus pallidi, substantia nigra, and dentate nuclei. Urine metabolome analysis revealed elevated GHB, which led to a biochemical diagnosis of SSADH deficiency. Genetic analysis of the ALDH5A1 gene revealed a novel missense mutation c.1586G&gt;A inherited from his father. It also demonstrated three single nucleotide polymorphisms (SNPs) (c.106G&gt;C, c.538C&gt;T, and c.545C&gt;T), all of which were inherited from his mother and are known to reduce SSADH enzyme activity. There were no duplications or deletions in other exons in the patient or his parents. No variants in the upstream, intronic, or downstream regions of the ALDH5A1 gene were found in the patient. Enzymatic assay revealed a marked reduction of SSADH enzyme activity (approximate to 2% of the lower limit of the normal range).
    Conclusion: Although other mechanisms cannot be fully excluded, the clinical manifestation of SSADH deficiency in this patient may be attributed to the combined effect of the mutation and the three enzyme activity-reducing SNPs. Urine metabolome analysis effectively detected his elevated GHB and is thus considered to be a good screening method for this underdiagnosed and potentially manageable metabolic disorder. (C) 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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  • Idiopathic focal epilepsies: the "lost tribe" 査読

    Deb K. Pal, Colin Ferrie, Laura Addis, Tomoyuki Akiyama, Giuseppe Capovilla, Roberto Caraballo, Anne de Saint-Martin, Natalio Fejerman, Renzo Guerrini, Khalid Hamandi, Ingo Helbig, Andreas A. Ioannides, Katsuhiro Kobayashi, Dennis Lal, Gaetan Lesca, Hiltrud Muhle, Bernd A. Neubauer, Tiziana Pisano, Gabrielle Rudolf, Caroline Seegmuller, Takashi Shibata, Anna Smith, Pasquale Striano, Lisa J. Strug, Pierre Szepetowski, Thalia Valeta, Harumi Yoshinaga, Michalis Koutroumanidis

    EPILEPTIC DISORDERS   18 ( 3 )   252 - 288   2016年9月

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    記述言語:英語   出版者・発行元:JOHN LIBBEY EUROTEXT LTD  

    The term idiopathic focal epilepsies of childhood (IFE) is not formally recognised by the ILAE in its 2010 revision (Berg et al., 2010), nor are its members and boundaries precisely delineated. The IFEs are amongst the most commonly encountered epilepsy syndromes affecting children. They are fascinating disorders that hold many "treats" for both clinicians and researchers. For example, the IFEs pose many of the most interesting questions central to epileptology: how are functional brain networks involved in the manifestation of epilepsy? What are the shared mechanisms of comorbidity between epilepsy and neurodevelopmental disorders? How do focal EEG discharges impact cognitive functioning? What explains the age-related expression of these syndromes? Why are EEG discharges and seizures so tightly locked to slow-wave sleep? In the last few decades, the clinical symptomatology and the respective courses of many IFEs have been described, although they are still not widely appreciated beyond the specialist community. Most neurologists would recognise the core syndromes of IFE to comprise: benign epilepsy of childhood with centro-temporal spikes or Rolandic epilepsy (BECTS/RE); Panayiotopoulos syndrome; and the idiopathic occipital epilepsies (Gastaut and photosensitive types). The Landau-Kleffner syndrome and the related (idiopathic) epilepsy with continuous spikes and waves in sleep (CSWS or ESES) are also often included, both as a consequence of the shared morphology of the interictal discharges and their potential evolution from core syndromes, for example, CSWS from BECTS. Atypical benign focal epilepsy of childhood also has shared electro-clinical features-warranting inclusion. In addition, a number of less well-defined syndromes of IFE have been proposed, including benign childhood seizures with affective symptoms, benign childhood epilepsy with parietal spikes, benign childhood seizures with frontal or midline spikes, and benign focal seizures of adolescence.
    The term "benign" is often used in connection with the IFEs and is increasingly being challenged. Certainly most of these disorders are not associated with the devastating cognitive and behavioural problems seen with early childhood epileptic encephalopathies, such as West or Dravet syndromes. However, it is clear that specific, and sometimes persistent, neuropsychological deficits in attention, language and literacy accompany many of the IFEs that, when multiplied by the large numbers affected, make up a significant public health problem. Understanding the nature, distribution, evolution, risk and management of these is an important area of current research.A corollary to such questions regarding comorbidities is the role of focal interictal spikes and their enduring impact on cognitive functioning. What explains the paradox that epilepsies characterised by abundant interictal epileptiform abnormalities are often associated with very few clinical seizures? This is an exciting area in both clinical and experimental arenas and will eventually have important implications for clinical management of the whole child, taking into account not just seizures, but also adaptive functioning and quality of life. For several decades, we have accepted an evidence-free approach to using or not using antiepileptic drugs in IFEs. There is huge international variation and only a handful of studies examining neurocognitive outcomes. Clearly, this is a situation ready for an overhaul in practice.
    Fundamental to understanding treatment is knowledge of aetiology. In recent years, there have been several significant discoveries in IFEs from studies of copy number variation, exome sequencing, and linkage that prompt reconsideration of the "unknown cause" classification and strongly suggest a genetic aetiology. The IFE are strongly age-related, both with regards to age of seizure onset and remission. Does this time window solely relate to a similar age-related gene expression, or are there epigenetic factors involved that might also explain low observed twin concordance? The genetic (and epigenetic) models for different IFEs, their comorbidities, and their similarities to other neurodevelopmental disorders deserve investigation in the coming years. In so doing, we will probably learn much about normal brain functioning. This is because these disorders, perhaps more than any other human brain disease, are disorders of functional brain systems (even though these functional networks may not yet be fully defined). In June 2012, an international group of clinical and basic science researchers met in London under the auspices of the Waterloo Foundation to discuss and debate these issues in relation to IFEs. This Waterloo Foundation Symposium on the Idiopathic Focal Epilepsies: Phenotype to Genotype witnessed presentations that explored the clinical phenomenology, phenotypes and endophenotypes, and genetic approaches to investigation of these disorders. In parallel, the impact of these epilepsies on children and their families was reviewed. The papers in this supplement are based upon these presentations. They represent an updated state-of-the-art thinking on the topics explored.
    The symposium led to the formation of internationalworking groups under the umbrella of "Luke's Idiopathic Focal Epilepsy Project" to investigate various aspects of the idiopathic focal epilepsies including: semiology and classification, genetics, cognition, sleep, high-frequency oscillations, and parental resources (see www.childhood-epilepsy.org). The next sponsored international workshop, in June 2014, was on randomised controlled trials in IFEs and overnight learning outcome measures.

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  • Determination of CSF 5-methyltetrahydrofolate in children and its application for defects of folate transport and metabolism 査読

    Mari Akiyama, Tomoyuki Akiyama, Kaoruko Kanamaru, Mutsuko Kuribayashi, Hiroko Tada, Tsugumi Shiokawa, Soichiro Toda, Katsumi Imai, Yu Kobayashi, Jun Tohyama, Takafumi Sakakibara, Harumi Yoshinaga, Katsuhiro Kobayashi

    CLINICA CHIMICA ACTA   460   120 - 125   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Objective: To describe an assay of 5-methyltetrahydrofolate (5MTHF) in the cerebrospinal fluid (CSF) of children, to determine reference values, and to report the clinical significance of this assay in metabolic disorders affecting folate transport and metabolism.
    Methods: CSF 5MTHF was determined by high-performance liquid chromatography with fluorescent detection in pediatric patients including one with FOLR1 gene mutation and one with methylenetetrahydrofolate reductase (MTHFR) deficiency. CSF total folate was measured using an automated analyzer.
    Results: 5MTHF and total folate were determined in 188 and 93 CSF samples, respectively. CSF 5MTHF was high throughout the first six months of life and subsequently declined with age. Reference values of CSF 5MTHF and total folate were determined from 162 and 82 samples, respectively. The patient with FOLR1 gene mutation had extremely low CSF 5MTHF and total folate, though these values normalized after folinic acid supplementation. The patient with MTHFR deficiency had extremely low 5MTHF and moderately low total folate; these values were not associated and showed no significant change after folic acid supplementation.
    Conclusions: This 5MTHF assay is simple, rapid, sensitive, reliable, and cost-effective. It will aid in the diagnosis and therapeutic monitoring of metabolic disorders affecting folate transport and metabolism. (C) 2016 Elsevier B.V. All rights reserved.

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  • A Japanese case of hereditary chin trembling responsive to arotinolol 査読

    Tomoyuki Akiyama, Hiroyuki Miyahara, Kenji Waki, Harumi Yoshinaga, Katsuhiro Kobayashi

    PARKINSONISM & RELATED DISORDERS   29   133 - 134   2016年8月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI LTD  

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  • Predictive factors for relapse of epileptic spasms after adrenocorticotropic hormone therapy in West syndrome 査読

    Yumiko Hayashi, Harumi Yoshinaga, Tomoyuki Akiyama, Fumika Endoh, Yoko Ohtsuka, Katsuhiro Kobayashi

    BRAIN & DEVELOPMENT   38 ( 1 )   32 - 39   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Purpose: To investigate whether serial electroencephalographic (EEG) findings can predict relapse of epileptic spasms after synthetic adrenocorticotropic hormone (ACTH) therapy in patients with West syndrome (WS).
    Subjects and methods: Thirty-nine WS patients (8 cryptogenic and 31 symptomatic) were included in this study. These patients received ACTH therapy for the first time and were regularly followed up for more than three years at our hospital. Sixteen patients (41.0%) showed seizure relapse (relapse group) and 23 patients (59.0%) did not show relapse (non-relapse group). We used survival analysis to investigate the influence of etiology and presence of epileptic discharges after the ACTH therapy on seizure outcome.
    Results: Immediately after the ACTH therapy, etiology was associated with seizure outcome (p = 0.003). In the early stage (1 month after the ACTH therapy), only the presence of epileptic discharges (p = 0.001) had a significant association with seizure outcome, regardless of etiology. Because all relapsed patients were in the symptomatic group, we performed the same statistical analysis on symptomatic WS patient data only. We found that the group with no epileptic discharges on EEG showed a significantly higher seizure-free rate than those with epileptic discharges in the early stage (p = 0.0091).
    Conclusion: This study demonstrated that serial EEG findings after ACTH therapy are significantly related to relapse of epileptic spasms. (c) 2015 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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  • Total folate and 5-methyltetrahydrofolate in the cerebrospinal fluid of children: correlation and reference values 査読

    Tomoyuki Akiyama, Hiroko Tada, Tsugumi Shiokawa, Katsuhiro Kobayashi, Harumi Yoshinaga

    CLINICAL CHEMISTRY AND LABORATORY MEDICINE   53 ( 12 )   2009 - 2014   2015年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WALTER DE GRUYTER GMBH  

    Background: Cerebral folate deficiency (CFD) may be underdiagnosed, as it manifests with various non-specific neurological symptoms. The diagnosis of CFD requires a determination of 5-methyltetrahydrofolate (5MTHF) in the cerebrospinal fluid (CSF), which is available in a limited number of specialized laboratories. In clinical biochemistry laboratories, total folate (TF) determination in serum or plasma is routinely performed by automated analyzers. The aim of this study is to determine whether the automated assay of CSF TF is a helpful screening tool for CFD.
    Methods: We analyzed CSF samples collected from 73 pediatric patients. We measured CSF TF, serum TF, and CSF 5MTHF in 73, 70, and 48 patients, respectively. The assay of 5MTHF was conducted by a newly developed system utilizing liquid chromatography-tandem mass spectrometry (LC-MS/ MS). We investigated the correlation between TF and 5MTHF in the CSF.
    Results: There was a strong positive correlation between CSF TF and 5MTHF (rho=0.930, p&lt;0.0001, n=48). Age was negatively correlated with CSF TF (rho=-0.557, p&lt;0.0001, n=51), serum TF (rho=-0.457, p=0.0008, n=51), and CSF 5MTHF (rho=-0.387, p=0.0263, n=33), but not with the CSF/serum TF ratio.
    Conclusions: The automated assay of CSF TF is helpful to estimate CSF 5MTHF. The CSF TF assay may have a significant impact on the early diagnosis of CFD, because clinicians have better access to it than the 5MTHF assay.

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  • Spatial relationship between fast and slow components of ictal activities and interictal epileptiform discharges in epileptic spasms 査読

    Tomoyuki Akiyama, Mari Akiyama, Katsuhiro Kobayashi, Tohru Okanishi, Cyrus G. Boelman, Dragos A. Nita, Ayako Ochi, Cristina Y. Go, O. Carter Snead, James T. Rutka, James M. Drake, Sylvester Chuang, Hiroshi Otsubo

    CLINICAL NEUROPHYSIOLOGY   126 ( 9 )   1684 - 1691   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: We analyzed the spatial distribution and concordance of fast (&gt;10 Hz) and slow (&lt;5 Hz) electroencephalogram (EEG) components of ictal activities and interictal epileptiform discharges (IIED) recorded by intracranial video EEG (IVEEG) in children with epileptic spasms (ES).
    Methods: We studied eight children with ES, who underwent IVEEG before resective surgery for epilepsy. We quantified the root-mean-square (RMS) amplitude of the fast and slow components of ictal activities during ES and IIED. We compared the concordance between the spatial distributions of the fast and slow components of ES and IIED.
    Results: There was a larger concordance between the spatial distributions of the fast and slow components in IIED than in ES (p = 0.0206 and 0.0401).
    Conclusions: The spatial concordance between the fast and slow EEG components was significantly different between ES and IIED.
    Significance: The mechanisms underlying the generation of slow EEG components may differ between ES and IIED. The slow EEG components of ES might indicate an extensive epileptic network involving remote symptomatic zones for ES in either the cortical or subcortical areas. The high spatial concordance between the fast and slow components of IIED suggests the involvement of a local inhibitory process within the epileptic cortex. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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  • Progressive brain atrophy in Schinzel-Giedion syndrome with a SETBP1 mutation 査読

    Akihito Takeuchi, Nobuhiko Okamoto, Shoko Fujinaga, Hirosuke Morita, Junya Shimizu, Tomoyuki Akiyama, Shinsuke Ninomiya, Jun-ichi Takanashi, Toshihide Kubo

    EUROPEAN JOURNAL OF MEDICAL GENETICS   58 ( 8 )   369 - 371   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Schinzel-Giedion syndrome is a rare congenital malformation syndrome. Recently, SETBP1 was identified as the causative gene. Herein, we present a Japanese boy with Schinzel-Giedion syndrome resulting from a novel mutation in SETBP1 in order to establish the clinical features and serial MRI findings associated with the syndrome. On the third day of life, the boy was referred to our hospital because of facial abnormalities and feeding difficulty. Midfacial retraction, frontal bossing, deep groove under the eyes, upturned nose, low-set ears, bilateral cryptorchidism, and generalized hypertrichosis were identified on admission. At the age of 7 months, epileptic spasms in series occurred. Based on characteristic facial and skeletal abnormalities and severe developmental delay, we clinically diagnosed him with Schinzel-Giedion syndrome. Direct sequencing of the SETBP1 gene revealed a heterozygous mutation (p.Ile871Ser) in exon 4. Although neither cardiac defect nor choanal stenosis were present in our case, the phenotype of our case was nearly identical to those of previously reported cases confirmed by genetic analysis. Serial MRI from the age of 1 month-3 years revealed progressive brain atrophy, especially in the white matter and basal ganglia. However, myelination was age-appropriate and no obvious abnormal signals in the white matter were seen. Diffusion weighted imaging revealed no abnormal findings. Accumulation of MRI data including diffusion weighted imaging from Schinzel-Giedion syndrome cases is needed to understand the mechanism underlying progressive brain atrophy in this syndrome. (C) 2015 Elsevier Masson SAS. All rights reserved.

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  • Action potentials contribute to epileptic high-frequency oscillations recorded with electrodes remote from neurons 査読

    Katsuhiro Kobayashi, Tomoyuki Akiyama, Iori Ohmori, Harumi Yoshinaga, Jean Gotman

    CLINICAL NEUROPHYSIOLOGY   126 ( 5 )   873 - 881   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: The importance of epileptic high-frequency oscillations (HFOs) in electroencephalogram (EEG) is growing. Action potentials generating some HFOs are observed in the vicinity of neurons in experimental animals. However electrodes that are remote from neurons, as in case of clinical situations, should not record action potentials. We propose to resolve this question by a realistic simulation of epileptic neuronal network.
    Methods: The rat dentate gyrus with sclerosis was simulated in silico. We computed the current dipole moment generated by each granule cell and the field potentials in a measurement area far from neurons.
    Results: The dentate gyrus was stimulated through synaptic input to evoke discharges resembling interictal epileptiform discharges, which had superimposed HFOs &lt;= 295 Hz that were recordable with remote electrodes and represented bursts of action potentials of granule cells. The increase in power of HFOs was associated with the progression of sclerosis, the reduction of GABAergic inhibition, and the increase in cell connectivity. Spectral frequency of HFOs had similar tendencies.
    Conclusions: HFOs recorded with electrodes remote from neurons could actually be generated by clusters of action potentials. Significance: The phenomenon of action potentials recorded with remote electrodes can possibly extend the clinical meaning of EEG. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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  • Phenotypic Variability in Childhood of Skeletal Muscle Sodium Channelopathies 査読

    Harumi Yoshinaga, Shunichi Sakoda, Takashi Shibata, Tomoyuld Aldyama, Makio Oka, Jun-Hui Yuan, Hiroshi Takashima, Masanori P. Takahashi, Tetsuro Kitamura, Nagako Murakami, Katsuhiro Kobayashi

    PEDIATRIC NEUROLOGY   52 ( 5 )   504 - 508   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    BACKGROUND: Mutations of the SCN4A gene cause several skeletal muscle channelopathies and overlapping forms of these disorders. However, the variability of the clinical presentation in childhood is confusing and not fully understood among pediatric neurologists. PATIENTS: We found three different mutations (p.V445M, p.I693L, and a novel mutation, p.V1149L) in SCN4A but not in the CLCN1 gene. The patient with p.V445M showed the clinical phenotype of sodium channel myotonia, but her clear symptoms did not appear until 11 years of age. Her younger sister and mother, who have the same mutation, displayed marked intrafamilial phenotypic heterogeneity from mild to severe painful myotonia with persistent weakness. The patient with p.I693L exhibited various symptoms that evolved with age, including apneic episodes, tonic muscular contractions during sleep, fluctuating severe episodic myotonia, and finally episodic paralyses. The patient with the novel p.V1149L mutation exhibited episodic paralyses starting at 3 years of age, and myotonic discharges were detected at 11 years of age for the first time. CONCLUSION: The present cohort reveals the complexity, variability, and overlapping nature of the clinical features of skeletal muscle sodium channelopathies. These are basically treatable disorders, so it is essential to consider genetic testing before the full development of a patient's condition.

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  • Trend figures assist with untrained emergency electroencephalogram interpretation 査読

    Katsuhiro Kobayashi, Kosuke Yunoki, Kazumasa Zensho, Tomoyuki Akiyama, Makio Oka, Harumi Yoshinaga

    BRAIN & DEVELOPMENT   37 ( 5 )   487 - 494   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Objective: Acute electroencephalogram (EEG) findings are important for diagnosing emergency patients with suspected neurological disorders, but they can be difficult for untrained medical staff to interpret. In this research, we will develop an emergency EEG trend figure that we hypothesize will be more easily understood by untrained staff compared with the raw original traces. Methods: For each of several EEG patterns (wakefulness, sleep, seizure activity, and encephalopathy), trend figures incorporating information on both amplitude and frequency were built. The accuracy of untrained reviewers' interpretation was compared with that of the raw EEG trace interpretation. Results: The rate of correct answers was significantly higher in response to the EEG trend figures than to the raw traces showing wakefulness, sleep, and encephalopathy, but there was no difference when seizure activity patterns were viewed. The rates of misjudging normal or abnormal findings were significantly lower with the trend figures in the wakefulness pattern; in the other patterns, misjudgments were equally low for the trend figures and the raw traces. Conclusion: EEG trend figures improved the accuracy with which untrained medical staff interpreted emergency EEGs. Emergency EEG figures that can be understood intuitively with minimal training might improve the accuracy of emergency EEG interpretation. However, additional studies are required to confirm these results because there may be many types of clinical EEGs that are difficult to interpret. (C) 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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  • A Storm of Fast (40-150Hz) Oscillations during Hypsarrhythmia in West Syndrome 査読

    Katsuhiro Kobayashi, Tomoyuki Akiyama, Makio Oka, Fumika Endoh, Harumi Yoshinaga

    ANNALS OF NEUROLOGY   77 ( 1 )   58 - 67   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    ObjectiveFast oscillations (FOs) were first explored from scalp electroencephalographic (EEG) data from hypsarrhythmia in West syndrome (infantile spasms) to investigate the meaning of FOs in this epileptic encephalopathy.
    MethodsIn 17 infants with West syndrome, we conservatively detected fast frequency peaks that stood out from the time-frequency spectral background with square root power&gt;1 mu V (spectral criterion) and corresponded to clear FOs with at least 4 oscillations in the filtered EEG traces (waveform criterion) in sleep EEGs.
    ResultsWe found a total of 1,519 interictal FOs that fulfilled both the spectral and waveform criteria. The FOs with a median frequency of 56.6Hz (range=41.0-140.6Hz) were dense, with a median rate of 66 (range=24-171) per minute before adrenocorticotropic hormone (ACTH) treatment, which was significantly higher than that in control infants without seizures (median=1, p&lt;0.001). The FOs were reduced by treatment. The mean gamma and ripple oscillation rates that were detected using the waveform criterion alone were 40.62/min and 15.75/min, respectively, per channel; these results were 112.8 and 98.4 times higher, respectively, than the previously reported corresponding rates in adult epilepsy patients.
    InterpretationThe observed FOs corresponded to epileptogenicity because of their close relation to the severity of hypsarrhythmia during the course of ACTH treatment. The very high epileptic FO rates in hypsarrhythmia are thought to affect the process of neurodevelopment by interfering with physiological functions in West syndrome, taking into account that high frequencies are also important in physiological higher brain functions. ANN NEUROL 2015;77:58-67

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  • Manifestation of both emetic seizures and sylvian seizures in the same patients with benign partial epilepsy 査読

    Harumi Yoshinaga, Katsuhiro Kobayashi, Takashi Shibata, Takushi Inoue, Makio Oka, Tomoyuki Akiyama

    BRAIN & DEVELOPMENT   37 ( 1 )   13 - 17   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Purpose: Benign childhood epilepsy with centro-temporal spikes (BECTS) and Panayiotopoulos syndrome (PS) have different pathophysiologies and show different types of seizures, yet they overlap in some important respects. In an attempt to understand the ways in which they differ from each other and overlap each other, we performed a detailed investigation on patients who had both characteristic types of seizure manifestations, namely, sylvian seizures and emetic seizures. Subjects and methods: We recruited consecutive subjects from the EEG database of outpatients who had visited our hospital between 2008 and 2010 and who had been diagnosed with BECTS or PS. As a result, 45 patients with BECTS and 50 patients with PS were selected from the database. Viewing the clinical records of these 95 patients, five patients were selected who had experienced both sylvian seizures and emetic seizures. Next, the clinical features and EEG findings of these five patients were retrospectively observed at the date of investigation: October 1, 2011. Results: We found that all the patients showed rolandic spikes when they had sylvian seizures, and occipital spikes or multifocal spikes when they had emetic seizures. We also report in detail on one patient who showed two different types of ictal EEG patterns: one of which started in the occipital area and the other of which was located in the rolandic area. Conclusion: Based on these findings, we conclude that widespread cortical hyperexcitability that includes the occipital area is necessary to produce the autonomic seizure manifestations seen in PS. (C) 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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  • Novel PLA2G6 mutations associated with an exonic deletion due to non-allelic homologous recombination in a patient with infantile neuroaxonal dystrophy. 査読

    Yamamoto T, Shimojima K, Shibata T, Akiyama M, Oka M, Akiyama T, Yoshinaga H, Kobayashi K

    Human genome variation   2   15048   2015年

  • Interictal high frequency oscillations correlating with seizure outcome in patients with widespread epileptic networks in tuberous sclerosis complex 査読

    Tohru Okanishi, Tomoyuki Akiyama, Shin-Ichi Tanaka, Ellen Mayo, Ayu Mitsutake, Cyrus Boelman, Cristina Go, O. Carter Snead, James Drake, James Rutka, Ayako Ochi, Hiroshi Otsubo

    EPILEPSIA   55 ( 10 )   1602 - 1610   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    ObjectiveMultiple tubers in patients with tuberous sclerosis complex (TSC) often are responsible for drug-resistant epilepsy. The complexity of the epileptic network formed by multiple tubers complicates localization of the epileptogenic zone that is needed to design a surgical treatment strategy. High frequency oscillations (HFOs) on intracranial video-electroencephalography (IVEEG) may be a valuable surrogate marker for the localization of the epileptogenic zone. The purpose of this study was to test the hypothesis that high occurrence rate (OR) of interictal HFOs can guide the localization of the epileptogenic zone.
    MethodsWe analyzed the OR of interictal HFOs at 80-200Hz (ripples) and &gt;200Hz (fast ripples, FRs). We divided OR of interictal HFOs between high and low rates by thresholding. We analyzed the correlation between seizure outcomes using Engel classification and the resection ratio of the seizure onset zone (SOZ), and high-OR HFOs using ordinal logistic regression analysis.
    ResultsWe collected 10 patients. The seizure outcomes resulted in Engel classification I in three patients, II in four, III in one, and IV in two. High-OR ripples (5-57 [mean 29] channels, 1-4 [2.8] lobes) and high-OR FRs (9-66 [mean 27] channels, 1-4 [2.6] lobes) were widely distributed. The resection ratio of SOZ did not show statistically significant correlation with the seizure outcome. The resection ratio of high-OR ripples showed statistically significant correlation with the seizure outcome (p=0.038). The resection ratio of high-OR FRs showed statistically significant correlation with the seizure outcome (p=0.048).
    SignificanceThe multiple extensive zones with high-OR HFOs suggest a complex and widespread epileptic network in patients with TSC. In a subset of TSC patients with drug-resistant epilepsy, resection of cortex with both interictal high-OR FRs and ripples on IVEEG correlated with a good seizure outcome.

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  • Five pediatric cases of ictal fear with variable outcomes 査読

    Mari Akiyama, Katsuhiro Kobayashi, Takushi Inoue, Tomoyuki Akiyama, Harumi Yoshinaga

    BRAIN & DEVELOPMENT   36 ( 9 )   758 - 763   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Purpose: Ictal fear is an uncommon condition in which fear manifests as the main feature of epileptic seizures. The literature has suggested that ictal fear is generally associated with poor seizure outcomes. We wanted to clarify the variability in seizure outcome of children with ictal fear. Subjects and methods: We identified five pediatric patients with ictal fear who were followed up on at Okayama University Hospital between January 2003 and December 2012. We retrospectively reviewed their clinical records and EEG findings. Results: The onset age of epilepsy ranged from 8 months to 9 years and 10 months. The common ictal symptoms were sudden fright, clinging to someone nearby, and subsequent impairment of consciousness, which were often accompanied by complex visual hallucinations and psychosis-like complaints. Ictal fear, in four patients, was perceived as a nonepileptic disorder by their parents. Ictal electroencephalograms (EEG) of ictal fear were obtained in all patients. Three showed frontal onset, while the other two showed centrotemporal or occipital onsets. Two patients were seizure free at last follow-up, while seizures persisted in the other three. A patient with seizure onset during infancy had a favorable outcome, which was considered to be compatible with benign partial epilepsy with affective symptoms. Conclusion: Ictal fear is not always associated with a symptomatic cause or a poor seizure outcome. It is quite important to make a correct diagnosis of ictal fear as early as possible to optimize treatment. (C) 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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  • Genotype-phenotype correlations in alternating hemiplegia of childhood 査読

    Masayuki Sasaki, Atsushi Ishii, Yoshiaki Saito, Naoya Morisada, Kazumoto Iijima, Satoshi Takada, Atsushi Araki, Yuko Tanabe, Hidee Arai, Sumimasa Yamashita, Tsukasa Ohashi, Yoichiro Oda, Hiroshi Ichiseki, Shininchi Hirabayashi, Akihiro Yasuhara, Hisashi Kawawaki, Sadami Kimura, Masayuki Shimono, Seiro Narumiya, Motomasa Suzuki, Takeshi Yoshida, Yoshinobu Oyazato, Shuichi Tsuneishi, Shiro Ozasa, Kenji Yokochi, Sunao Dejima, Tomoyuki Akiyama, Nobuyuki Kishi, Ryutaro Kira, Toshio Ikeda, Hirokazu Oguni, Bo Zhang, Shoji Tsuji, Shinichi Hirose

    NEUROLOGY   82 ( 6 )   482 - 490   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Objective:Clinical severity of alternating hemiplegia of childhood (AHC) is extremely variable. To investigate genotype-phenotype correlations in AHC, we analyzed the clinical information and ATP1A3 mutations in patients with AHC.Methods:Thirty-five Japanese patients who were clinically diagnosed with AHC participated in this study. ATP1A3 mutations were analyzed using Sanger sequencing. Detailed clinical information was collected from family members of patients with AHC and clinicians responsible for their care.Results:Gene analysis revealed 33 patients with de novo heterozygous missense mutations of ATP1A3: Glu815Lys in 12 cases (36%), Asp801Asn in 10 cases (30%), and other missense mutations in 11 cases. Clinical information was compared among the Glu815Lys, Asp801Asn, and other mutation groups. Statistical analysis revealed significant differences in the history of neonatal onset, gross motor level, status epilepticus, and respiratory paralysis in the Glu815Lys group compared with the other groups. In addition, 8 patients who did not receive flunarizine had severe motor deteriorations.Conclusions:The Glu815Lys genotype appears to be associated with the most severe AHC phenotype. Although AHC is not generally seen as a progressive disorder, it should be considered a disorder that deteriorates abruptly or in a stepwise fashion, particularly in patients with the Glu815Lys mutation.

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  • Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms 査読

    George M. Ibrahim, Simeon M. Wong, Ryan A. Anderson, Gabrielle Singh-Cadieux, Tomoyuki Akiyama, Ayako Ochi, Hiroshi Otsubo, Tohru Okanishi, Taufik A. Valiante, Elizabeth Donner, James T. Rutka, O. Carter Snead, Sam M. Doesburg

    EXPERIMENTAL NEUROLOGY   251   30 - 38   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Pathological high frequency oscillations (pHFOs) have been proposed to be robust markers of epileptic cortex. Oscillatory activity below this frequency range has been shown to be modulated by phase of lower frequency oscillations. Here, we tested the hypothesis that dynamic cross-frequency interactions involving pHFOs are concentrated within the epileptogenic cortex. Intracranial electroencephalographic recordings from 17 children with medically-intractable epilepsy secondary to focal cortical dysplasia were obtained. A time-resolved analysis was performed to determine topographic concentrations and dynamic changes in cross-frequency amplitude-to-phase coupling (CFC). CFC between pHFOs and the phase of theta and alpha rhythms was found to be significantly elevated in the seizure-onset zone compared to non-epileptic regions (p &lt; 0.01). Data simulations showed that elevated CFC could not be attributed to the presence of sharp transients or other signal properties. The phase of low frequency oscillations at which pHFO amplitudes were maximal was inconsistent at seizure initiation, yet consistently at the trough of the low frequency rhythm at seizure termination. Amplitudes of pHFOs were most significantly modulated by the phase of alpha-band oscillations (p &lt; 0.01). These results suggest that increased CFC between pHFO amplitude and alpha phase may constitute a marker of epileptogenic brain areas and may be relevant for understanding seizure dynamics. (C) 2013 Elsevier Inc All rights reserved.

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  • CSF/plasma ratios of amino acids: Reference data and transports in children 査読

    Tomoyuki Akiyama, Katsuhiro Kobayashi, Akihito Higashikage, Junko Sato, Harumi Yoshinaga

    BRAIN & DEVELOPMENT   36 ( 1 )   3 - 9   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Objective: We intended to investigate the effects of age, gender, and medications on amino acid cerebrospinal fluid (CSF)/plasma ratios in children, and to determine whether amino acid transports across the blood CSF barrier in children differ from those in adults. Patients and methods: Amino acid concentrations measured by ion-exchange high-performance liquid chromatography were used (CSF from 99 children, simultaneously collected plasma from 76 children). Influence of age, gender, and medications on the amino acid CSF concentrations and CSF/plasma ratios were analyzed by linear multiple regression. Interactions of amino acid transports were analyzed by correlation analysis of CSF/plasma ratios. Results: CSF/plasma ratios of serine, valine, histidine, and arginine were higher in younger children. The glutamate CSF/plasma ratio was higher in older children. Serine, alanine, threonine, valine, and histidine CSF/plasma ratios were lower in females. Glutamine, methionine, tyrosine, and phenylalanine CSF/plasma ratios were elevated with valproate therapy. Serine, threonine, valine, leucine, and tyrosine CSF/plasma ratios were lower with clobazam therapy. The asparagine CSF/plasma ratio was elevated with pyridoxal phosphate therapy. Transports of most essential neutral amino acids interacted with each other, as did neutral amino acids with low molecular weights. Cationic amino acids interacted with each other and some essential neutral amino acids. Acidic amino acids had no interactions with other amino acids. Conclusions: Age, gender, and anti-epileptic drugs affect amino acid CSF/plasma ratios in children. Transport interactions between amino acids in children showed no remarkable difference from those of adults and generally followed the substrate specificities of multiple amino acid transport systems. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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  • A Japanese adult case of guanidinoacetate methyltransferase deficiency. 査読

    Akiyama T, Osaka H, Shimbo H, Nakajiri T, Kobayashi K, Oka M, Endoh F, Yoshinaga H

    JIMD reports   12   65 - 69   2014年

  • Neocortical pathological high-frequency oscillations are associated with frequency-dependent alterations in functional network topology 査読

    George M. Ibrahim, Ryan Anderson, Tomoyuki Akiyama, Ayako Ochi, Hiroshi Otsubo, Gabrielle Singh-Cadieux, Elizabeth Donner, James T. Rutka, O. Carter Snead, Sam M. Doesburg

    JOURNAL OF NEUROPHYSIOLOGY   110 ( 10 )   2475 - 2483   2013年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER PHYSIOLOGICAL SOC  

    Synchronization of neural oscillations is thought to integrate distributed neural populations into functional cell assemblies. Epilepsy is widely regarded as a disorder of neural synchrony. Knowledge is scant, however, regarding whether ictal changes in synchrony involving epileptogenic cortex are expressed similarly across various frequency ranges. Cortical regions involved in epileptic networks also exhibit pathological high-frequency oscillations (pHFOs, &gt;80 Hz), which are increasingly utilized as biomarkers of epileptogenic tissue. It is uncertain how pHFO amplitudes are related to epileptic network connectivity. By calculating phase-locking values among intracranial electrodes implanted in children with intractable epilepsy, we constructed ictal connectivity networks and performed graph theoretical analysis to characterize their network properties at distinct frequency bands. Ictal data from 17 children were analyzed with a hierarchical mixed-effects model adjusting for patient-level covariates. Epileptogenic cortex was defined in two ways: 1) a hypothesis-driven method using the visually defined seizure-onset zone and 2) a data-agnostic method using the high-frequency amplitude of each electrode. Epileptogenic cortex exhibited a logarithmic decrease in interregional functional connectivity at high frequencies (&gt;30 Hz) during seizure initiation and propagation but not at termination. At slower frequencies, conversely, epileptogenic cortex expressed a relative increase in functional connectivity. Our findings suggest that pHFOs reflect epileptogenic network interactions, yielding theoretical support for their utility in the presurgical evaluation of intractable epilepsy. The view that abnormal network synchronization plays a critical role in ictogenesis and seizure dynamics is supported by the observation that functional isolation of epileptogenic cortex at high frequencies is absent at seizure termination.

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  • Cortical contribution to scalp EEG gamma rhythms associated with epileptic spasms 査読

    Katsuhiro Kobayashi, Kazushi Miya, Tomoyuki Akiyama, Fumika Endoh, Makio Oka, Harumi Yoshinaga, Yoko Ohtsuka

    BRAIN & DEVELOPMENT   35 ( 8 )   762 - 770   2013年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The cortical contribution for the generation of gamma rhythms detected from scalp ictal EEG was studied in unique cases of epileptic spasms and a review of the related literature was conducted. Ictal scalp gamma rhythms were investigated through time frequency analysis in two cases with a combination of focal seizures and spasms and another case with spasms associated with cortical dysplasia. In the two patients with combined seizures, the scalp distribution of ictal gamma rhythms was related to that of focal seizure activity. In the third patient, an asymmetric distribution of the ictal scalp gamma rhythms was transiently revealed in correspondence to the dysplasic cortex during hormonal treatment. Therefore, the dominant region of scalp gamma rhythms may correspond to the epileptogenic cortical area. The current findings have reinforced the possibility of the cortical generation of ictal scalp gamma rhythms associated with spasms The detection of high frequencies through scalp EEG is a technical challenge, however, and the clinical significance of scalp gamma rhythms may not be the same as that of invasively recorded high frequencies. Further studies on the pathophysiological mechanisms related to the generation of spasms involving high frequencies are necessary in the future, and the development of animal models of spasms will play an important role in this regard. (C) 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.braindev.2012.12.012

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  • Clinical implications of preceding positive spikes in patients with benign partial epilepsy and febrile seizures 査読

    Harumi Yoshinaga, Katsuhiro Kobayashi, Tomoyuki Akiyama, Takashi Shibata, Fumika Endoh, Yoko Ohtsuka

    BRAIN & DEVELOPMENT   35 ( 4 )   299 - 306   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Purpose: To clarify the clinical implications of the preceding positive spikes (PPSs) observed primarily in rolandic spikes, we analyzed PPSs in the rolandic and occipital spikes observed in the electroencephalograms (EEGs) of patients with two types of benign partial epilepsies (benign childhood epilepsy with centro-temporal spikes [BECT] and Panayiotopoulos syndrome [PS]) and febrile seizures (FS). Subjects and methods: We identified patients from our outpatient EEG database that were seen between 2006 and 2008 that had BECT, PS, and FS with rolandic or occipital spikes. We generated an averaged spike for each patient from the rolandic and occipital spikes that were detected using an automatic spike detection and clustering system. We compared the presence rate of the averaged spikes with the PPS among the three groups (BECT vs. PS vs. FS) using sequential mapping. Results: We identified 25 BECT, 18 PS, and 15 FS patients with rolandic spikes. Fifteen BECT and nine PS patients exhibited a PPS in their averaged rolandic spikes, whereas only four FS patients did. Three of these four FS patients later developed afebrile seizures, and one of them was diagnosed as having PS. We analyzed eight PS and six FS patients with occipital spikes. Five PS patients exhibited a PPS in their averaged occipital spikes, whereas only one FS patient did. This FS patient later developed prolonged autonomic febrile seizures. Conclusion: PPSs are observed not only in rolandic spikes associated with BECT that is related strictly to sylvian seizures, but also in rolandic and occipital spikes associated with PS. Although PPSs are rare in such spikes observed in FS, patients with FS and PPSs may have an increased risk of developing afebrile seizures or prolonged autonomic febrile seizures. Further studies are warranted to determine the diagnostic utility of PPSs as a marker of the future development of epilepsy when they are observed in FS patients. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.braindev.2012.06.006

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  • Disruption of Rolandic Gamma-Band Functional Connectivity by Seizures is Associated with Motor Impairments in Children with Epilepsy 査読

    George M. Ibrahim, Tomoyuki Akiyama, Ayako Ochi, Hiroshi Otsubo, Mary Lou Smith, Margot J. Taylor, Elizabeth Donner, James T. Rutka, O. Carter Snead, Sam M. Doesburg

    PLOS ONE   7 ( 6 )   e39326   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Although children with epilepsy exhibit numerous neurological and cognitive deficits, the mechanisms underlying these impairments remain unclear. Synchronization of oscillatory neural activity in the gamma frequency range (&gt;30 Hz) is purported to be a mechanism mediating functional integration within neuronal networks supporting cognition, perception and action. Here, we tested the hypothesis that seizure-induced alterations in gamma synchronization are associated with functional deficits. By calculating synchrony among electrodes and performing graph theoretical analysis, we assessed functional connectivity and local network structure of the hand motor area of children with focal epilepsy from intracranial electroencephalographic recordings. A local decrease in inter-electrode phase synchrony in the gamma bands during ictal periods, relative to interictal periods, within the motor cortex was strongly associated with clinical motor weakness. Gamma-band ictal desychronization was a stronger predictor of deficits than the presence of the seizure-onset zone or lesion within the motor cortex. There was a positive correlation between the magnitude of ictal desychronization and impairment of motor dexterity in the contralateral, but not ipsilateral hand. There was no association between ictal desynchronization within the hand motor area and non-motor deficits. This study uniquely demonstrates that seizure-induced disturbances in cortical functional connectivity are associated with network-specific neurological deficits.

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  • Occipital lobe epilepsy in children: Characterization, evaluation and surgical outcomes 査読

    George M. Ibrahim, Aria Fallah, Gregory W. Albert, Teresa Withers, Hiroshi Otsubo, Ayako Ochi, Tomoyuki Akiyama, Elizabeth J. Donner, Shelly Weiss, O. Carter Snead, James M. Drake, James T. Rutka

    EPILEPSY RESEARCH   99 ( 3 )   335 - 345   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Introduction: Occipital lobe epilepsy (OLE) poses a diagnostic challenge to clinicians. Here, we present our experience in the surgical management of OLE in children using magnetoencephalography (MEG) in the pre-operative evaluation.
    Methods: Retrospective chart review was performed from 2000 to 2010 to identify patients with OLE. Patients were analyzed in two categories: isolated OLE (11 patients) and extended OLE (parietooccipital, temporooccipital, and temporoparietooccipital; 30 patients). Survival analysis and multivariate Cox proportional hazards regression were used to identify independent predictors of seizure outcome.
    Results: Forty-one patients with a mean follow-up of 3.1 years were identified with an overall 68% rate of satisfactory seizure outcome. Patients with extended OLE had younger ages at seizure onset and different seizure semiologies compared with those with isolated OLE. None of the latter underwent insertion of subdural grid electrodes for localization of the epileptogenic zone compared with 77% of the former (p &lt; 0.001). On multivariate analysis, the strongest independent predictor of unsatisfactory outcome was MEG dipoles in the occipital lobe contralateral to resection.
    Conclusion: Here, we find similar seizure outcomes for isolated and extended OLE foci despite the use of less invasive strategies for the former. Furthermore, we describe the role of MEG in evaluation, surgical planning and prognostication of children with OLE. (C) 2012 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.eplepsyres.2011.12.015

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  • Histopathology of cortex and white matter in pediatric epileptic spasms: Comparison with those of partial seizures 査読

    Yukiko Inage, William C. Halliday, Cristina Go, Ayako Ochi, Tomoyuki Akiyama, Mari Akiyama, Elysa Widjaja, Hiroshi Otsubo

    BRAIN & DEVELOPMENT   34 ( 2 )   118 - 123   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Epileptic spasms in older children have increasingly been recognized as a distinct seizure type and subset of these patients are considered for surgical resection. This study compares histopathology and magnetic resonance imaging (MRI), especially focusing the difference between the cortical grey matter and the subcortical white matter to understand the extensive epileptic brain in patients with epileptic spasms. We examined 22 patients consisting of 11 patients with epileptic spasms and 11 with partial seizures. Scalp video electroencephalography (EEG) showed interictal generalized epileptiform discharges (9 patients with epileptic spasms vs. 1 with partial seizures) and ictal generalized epileptiform discharges (10 vs. 3). We found MRI abnormalities in a single lobe (6 vs. 7) and multiple lobes (2 vs. 1). Surgical resections were performed across multiple lobes (9 vs. 2), comparing within a single lobe (2 vs. 9), (p &lt; 0.001). Histopathology showed abnormal cortical organizations as FCD (2 vs. 5) and microdysgenesis (4 vs. 4), normal (4 vs. 1). Two patients with epileptic spasms showed hyaline proteoplasmic astrocytopathy. There were heterotopic neurons (10 vs. 10), cluster of oligodendroglia (8 vs. 7), balloon cells (2 vs. 5) and blurred myelination (1 vs. 4), in the white matter. Seizure-free outcomes were seen in seven patients with epileptic spasms (64%) and four with partial seizures (36%). The multilobar epileptogenic zones existed in patients with epileptic spasms, compared with the focal epileptogenic zone in patients with partial seizures. There was no difference of MRI and histopathology findings in cortex and subcortical white matter between two groups. (C) 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.braindev.2011.03.009

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  • High kurtosis of intracranial electroencephalogram as a marker of ictogenicity in pediatric epilepsy surgery 査読

    Tomoyuki Akiyama, Makoto Osada, Masahide Isowa, Cristina Y. Go, Ayako Ochi, Irene M. Elliott, Mari Akiyama, O. Carter Snead, James T. Rutka, James M. Drake, Hiroshi Otsubo

    CLINICAL NEUROPHYSIOLOGY   123 ( 1 )   93 - 99   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: We determined whether kurtosis analysis of intracranial electroencephalogram (EEG) can estimate the localization of the epileptogenic zone.
    Methods: We analyzed 29 pediatric epilepsy patients who underwent intracranial EEG before focal resective surgery. We localized the brain regions with high kurtosis, the seizure onset zone (SOZ) and the regions with high-rate, high-amplitude and long-duration interictal paroxysms &gt;= 20 Hz. We tested correlations between the surgical resection of those regions and post-surgical seizure outcome, and correlations between kurtosis and the rate/amplitude/duration of interictal paroxysms.
    Results: The resection of the regions with high kurtosis correlated with 1-year post-surgical seizure outcome (p = 0.028) but not with 2-year outcome. Kurtosis showed more significant correlation with 1-year seizure outcome than the SOZ and the rate/amplitude/duration of interictal paroxysms. Kurtosis showed positive, independent correlations with the amplitude and duration of interictal paroxysms (p &lt; 0.0001) but not with the rate (p = 0.4).
    Conclusions: The regions with high kurtosis provide more reliable information to predict seizure outcome than the SOZ and the regions with high-rate/amplitude and long-duration interictal paroxysms. Kurtosis reflects combined effects of the amplitude and duration of the interictal paroxysms.
    Significance: High kurtosis suggests the regions with acquired ictogenicity within the irritative zone. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.clinph.2011.05.026

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  • Fast activity during EEG seizures in neonates 査読

    Lakshmi Nagarajan, Soumya Ghosh, Linda Palumbo, Tomoyuki Akiyama, Hiroshi Otsubo

    EPILEPSY RESEARCH   97 ( 1-2 )   162 - 169   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Introduction: Paroxysmal fast activity (FA) has been proposed as a marker for epileptic networks. We explore the presence and significance of ictal FA on scalp video EEG seizures (EEG Sz) recorded in neonates.
    Methodology: Forty two babies had 159 EEG Szs. The seizures were analysed for ictal FA, using a low frequency filter of 30 Hz. We explored the relationship of ictal FA to the occurrence of electroclinical and electrographic seizures, the use of phenobarbitone and to neurodevelopmental outcomes.
    Results: Ictal FA occurred in 62 (39%) of the 159 EEG Szs. In the 62 seizures with ictal FA, 34 (55%) were electroclinical seizures (ECSz) and 28 (45%) were electrographic (ESz). In the remaining 97 seizures without ictal FA, 27 (28%) were ECSz and 70 (72%) ESz. There was a significant correlation (p=0.0006) between ictal FA and electroclinical seizures. There was no relationship between phenobarbitone and presence of ictal FA. There was no significant difference in the background EEG, neuroimaging abnormalities, neurodevelopmental impairment or post neonatal seizures between those with and without ictal FA.
    Conclusions: Ictal FA is highly correlated to the occurrence of clinical features during an EEG seizure. The presence of ictal FA does not appear to influence neurodevelopmental outcomes. (C) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.eplepsyres.2011.08.003

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  • Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex 査読

    Ayako Ochi, Ryan Hung, Shelly Weiss, Elysa Widjaja, Tonia To, Yoshihiro Nawa, Taiki Shima, Cristina Go, Tomoyuki Akiyama, Elizabeth Donner, James Drake, James T. Rutka, O. Carter Snead, Hiroshi Otsubo

    EPILEPSIA   52 ( 11 )   1986 - 1994   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Purpose: We assessed lateralization of interictal epileptiform discharges (IEDs) in children with intractable epilepsy secondary to tuberous sclerosis complexes (TSCs) during rapid eye movement sleep (R), compared with non-rapid eye movement sleep (NR) and wakefulness (W), to determine epileptogenicity of R-IEDs.
    Methods: We retrospectively studied 23 children with TSC, who underwent prolonged scalp video-electroencephalography (EEG) and magnetic resonance imaging (MRI). We determined the lateralization of ictal EEG, clinical semiology, and the largest tuber on MRI. We analyzed a minimum of 100 IEDs during R, NR, and W to classify right/left/generalized spikes to compare the lateralization with ictal EEG, clinical semiology, and MRI.
    Key Findings: R-IEDs were lateralized in 22 patients (96%), W-IEDs in 19 (83%), and NR-IEDs in 16 (70%). Ictal EEGs were lateralized in 15 patients (65%) and clinical semiology in 5 (22%). Ictal EEG lateralization was concordant to R-IEDs in 14 patients (93%), W-IEDs in 11 (73%), and NR-IEDs in 10 (67%). The lateralization of clinical semiology was concordant with R-IEDs in 4 (80%), W-IEDs in 3 (60%), and NR-IEDs in 2 (40%). MRI lateralization of the largest tuber was concordant with R-IEDs in 16 (70%), W-IEDs in 12 (52%), and NR-IEDs in 11 (48%). Thirteen patients (57%) underwent resective surgery, the hemisphere of which was concordant with R-IEDs in 13 (100%), W-IEDs in 8 (62%), and NR-IEDs in 8 (62%). Nine (69%) of them achieved good seizure control after surgery.
    Significance: R provoked the most lateralized IEDs compared to NR and W in children with TSC. Lateralization of R-IEDs corresponded with the hemisphere of ictal EEG and largest tuber, and can be used to identify surgical candidacy in TSC children with intractable epilepsy.

    DOI: 10.1111/j.1528-1167.2011.03198.x

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  • Focal resection of fast ripples on extraoperative intracranial EEG improves seizure outcome in pediatric epilepsy 査読

    Tomoyuki Akiyama, Blathnaid McCoy, Cristina Y. Go, Ayako Ochi, Irene M. Elliott, Mari Akiyama, Elizabeth J. Donner, Shelly K. Weiss, O. Carter Snead, James T. Rutka, James M. Drake, Hiroshi Otsubo

    EPILEPSIA   52 ( 10 )   1802 - 1811   2011年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Purpose: High-frequency oscillations (HFOs), termed ripples at 80-200 Hz and fast ripples (FRs) at &gt;200/250 Hz, recorded by intracranial electroencephalography (EEG), may be a valuable surrogate marker for the localization of the epileptogenic zone. We evaluated the relationship of the resection of focal brain regions containing high-rate interictal HFOs and the seizure-onset zone (SOZ) determined by visual EEG analysis with the postsurgical seizure outcome, using extraoperative intracranial EEG monitoring in pediatric patients and automated HFO detection.
    Methods: We retrospectively analyzed 28 pediatric epilepsy patients who underwent extraoperative intracranial video-EEG monitoring prior to focal resection. Utilizing the automated analysis, we identified interictal HFOs during 20 min of sleep EEG and determined the brain regions containing high-rate HFOs. We investigated spatial relationships between regions with high-rate HFOs and SOZs. We compared the size of these regions, the surgical resection, and the amount of the regions with high-rate HFOs/SOZs within the resection area with seizure outcome.
    Key Findings: Ten patients were completely seizure-free and 18 were not at 2 years after surgery. The brain regions with high-rate ripples were larger than those with high-rate FRs (p = 0.0011) with partial overlap. More complete resection of the regions with high-rate FRs significantly correlated with a better seizure outcome (p = 0.046). More complete resection of the regions with high-rate ripples tended to improve seizure outcome (p = 0.091); however, the resection of SOZ did not influence seizure outcome (p = 0.18). The size of surgical resection was not associated with seizure outcome (p = 0.22-0.39).
    Significance: The interictal high-rate FRs are a possible surrogate marker of the epileptogenic zone. Interictal ripples are not as specific a marker of the epileptogenic zone as interictal FRs. Resection of the brain regions with high-rate interictal FRs in addition to the SOZ may achieve a better seizure outcome.

    DOI: 10.1111/j.1528-1167.2011.03199.x

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  • 非定型良性小児部分てんかん診断における脳磁図検査の有用性 査読

    白石 秀明, 萩野谷 和裕, 中川 栄二, 香坂 忍, 金子 裕, 須貝 研司, 植松 貢, 柿坂 庸介, 中里 信和, 花谷 亮典, 秋山 倫之, 齋藤 伸治, 大坪 宏

    てんかん研究   29 ( 2 )   337 - 337   2011年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • Jeavons syndrome existing as occipital cortex initiating generalized epilepsy 査読

    Sorawit Viravan, Cristina Go, Ayako Ochi, Tomoyuki Akiyama, O. Carter Snead, Hiroshi Otsubo

    EPILEPSIA   52 ( 7 )   1273 - 1279   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Purpose: Jeavons syndrome (JS) is one of the underreported epileptic syndromes characterized by eyelid myoclonia (EM), eye closure-induced seizures/electroencephalography (EEG) paroxysms, and photosensitivity. JS has been proposed as idiopathic generalized epilepsy (IGE) because of normal posterior dominant background activity and paroxysmal generalized ictal epileptiform discharges (EDs). However, we noticed subtle occipital EDs preceding EM and interictal posterior EDs using digital video-EEG. We studied clinical and EEG findings in JS to determine the specific occipital lobe relation to this "eye closure-induced'' reflex IGE.
    Methods: We identified 12 children who met the diagnostic criteria of JS from January 2004 to April 2009 at the Hospital for Sick Children, Toronto, Canada. All patients had EM captured by video-EEG. We reviewed and described ictal EEG patterns, interictal abnormalities, and demographics, clinical, and neuroimaging findings.
    Key Findings: All patients but one were female (92%). Age at seizure onset ranged from 1.5 to 9 years, with a mean age of 4.9 years. Six patients (50%) were previously diagnosed as having absence epilepsy and 10 patients were on antiepileptic medications. All 12 patients had normal posterior dominant alpha rhythm, reactive to eye opening and closure. Spiky posterior alpha activity was noted with sustained eye closure in six patients (50%). Interictally, there were generalized EDs found in 10 patients (83%); four of them also had focal interictal EDs over the posterior head region. Eleven patients (92%) had evidence of focal posterior ictal EDs. EM and/or paroxysmal EDs were induced by photic stimulation in 9 (75%) and hyperventilation in 7 (58%).
    Significance: We observed two neurophysiologic findings in JS: (1) focal interictal EDs from posterior head region; and (2) predominant focal posterior ictal EDs preceding generalized EDs. Further clinical observations of seizures induced by eye closure, photic stimulation, and hyperventilation along with EEG paroxysms would raise the possibility of the occipital cortex initiating generalized epilepsy network involving the brainstem, and thalamocortical and transcortical pathways in JS.

    DOI: 10.1111/j.1528-1167.2011.03068.x

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  • Focal-onset myoclonic seizures and secondary bilateral synchrony 査読

    Tomoyuki Akiyama, Elizabeth J. Donner, Cristina Y. Go, Ayako Ochi, O. Carter Snead, James T. Rutka, Hiroshi Otsubo

    EPILEPSY RESEARCH   95 ( 1-2 )   168 - 172   2011年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    We present a child with myoclonic seizures, epileptic spasms and generalized epileptiform discharges on scalp EEG. Magnetoencephalography and coherence-phase analysis for scalp EEG suggested focal onset in the left hemisphere. Intracranial video EEG confirmed seizure onset in the left frontal lobe with ictal high-frequency oscillations. Left frontal lobectomy suppressed his seizures. Subsets of myoclonic seizures can be focal in origin despite bilaterally synchronized epileptiform discharges on scalp EEG. (c) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.eplepsyres.2011.02.006

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  • Autoimmune Limbic Encephalitis as an Emerging Pediatric Condition: Case Report and Review of the Literature 査読

    Blathnaid McCoy, Tomoyuki Akiyama, Elysa Widjaja, Cristina Go

    JOURNAL OF CHILD NEUROLOGY   26 ( 2 )   218 - 222   2011年2月

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    記述言語:英語   出版者・発行元:SAGE PUBLICATIONS INC  

    Limbic encephalitis, first described in the 1960s as a paraneoplastic condition, has emerged as an autoimmune condition, occurring often without evidence of an underlying tumor. Many novel autoantibodies have been identified, and this diagnosis is increasingly being made in the pediatric population. This article reports the case of a 16-year-old boy who presented following gastrointestinal illness with subacute evolution of neuropsychiatric symptoms. Brain magnetic resonance imaging revealed progressive hippocampal signal abnormality and swelling. N-methyl-D-aspartate (NMDA) receptor antibody was detected in serum. The patient responded well to pharmacological immunotherapy but has residual cognitive deficits. The available literature on this condition is reviewed. Limbic encephalitis should be considered in the differential diagnosis in children presenting with encephalopathy, particularly with neuropsychiatric manifestations. Long-term surveillance and close follow-up are required to accurately clarify tumor risk and natural history of this condition in children and balance these factors with risks of radiation exposure through imaging.

    DOI: 10.1177/0883073810378536

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  • Topographic movie of intracranial ictal high-frequency oscillations with seizure semiology: Epileptic network in Jacksonian seizures 査読

    Tomoyuki Akiyama, Derrick W. Chan, Cristina Y. Go, Ayako Ochi, Irene M. Elliott, Elizabeth J. Donner, Shelly K. Weiss, O. Carter Snead, James T. Rutka, James M. Drake, Hiroshi Otsubo

    EPILEPSIA   52 ( 1 )   75 - 83   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

    P&gt;Purpose:
    We developed a technique to produce images of dynamic changes in ictal high-frequency oscillations (HFOs) &gt; 40 Hz recorded on subdural electroencephalography (EEG) that are time-locked to the ictal EEG and ictal semiology video. We applied this technique to Jacksonian seizures to demonstrate ictal HFO propagation along the homunculus in the primary sensory-motor cortex to visualize the underlying epileptic network.
    Methods:
    We analyzed intracranial ictal EEGs from two patients with intractable Jacksonian seizures who underwent epilepsy surgery. We calculated the degrees of increase in amplitude within 40-80, 80-200, and 200-300 Hz frequency bands compared to the interictal period and converted them into topographic movies projected onto the brain surface picture. We combined these data with the ictal EEGs and video of the patient demonstrating ictal semiology.
    Key Findings:
    The ictal HFOs began in the sensory cortex and appeared concomitantly with the sensory aura. They then propagated to the motor cortex at the same time that focal motor symptoms evolved. As the seizure progressed, the ictal HFOs spread or reverberated in the rolandic region. However, even when the seizure became secondarily generalized, the ictal HFOs were confined to the rolandic region. In both cases, there was increased amplitude of higher frequency bands during seizure initiation compared to seizure progression.
    Significance:
    This combined movie showed the ictal HFO propagation corresponding to the ictal semiology in Jacksonian seizures and revealed the epileptic network involved in seizure initiation and progression. This method may advance understanding of neural network activities relating to clinical seizure generation and propagation.

    DOI: 10.1111/j.1528-1167.2010.02776.x

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  • Cortical Gamma-Oscillations Modulated by Auditory-Motor Tasks-Intracranial Recording in Patients With Epilepsy 査読

    Tetsuro Nagasawa, Robert Rothermel, Csaba Juhasz, Miho Fukuda, Masaaki Nishida, Tomoyuki Akiyama, Sandeep Sood, Eishi Asano

    HUMAN BRAIN MAPPING   31 ( 11 )   1627 - 1642   2010年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Human activities often involve hand-motor responses following external auditory verbal commands It has been believed that hand movements are predominantly driven by the contralateral primary sensorimotor cortex, whereas auditory-verbal information is processed in both superior temporal gyn. It remains unknown whether cortical activation in the superior temporal gyrus during an auditory motor task is affected by laterality of hand-motor responses Here, event-related gamma-oscillations were intracranially recorded as quantitative measures of cortical activation; we determined how cortical structures were activated by auditory-cued movement Using each hand in 15 patients with focal epilepsy. Auditory-verbal stimuli elicited augmentation of gamma-oscillations in a posterior portion of the superior temporal gyrus, whereas hand-motor responses elicited gamma-augmentation in the pre- and postcentral gyn. The magnitudes of such gamma-augmentation in the superior temporal, precentral, and postcentral gyn were significantly larger when the hand contralateral to the recorded hemisphere was required to be used for motor responses, compared with when the ipsilateral hand was. The superior temporal gyrus in each hemisphere might play a greater pivotal role when the contralateral hand needs to be used for motor responses, compared with when the ipsilateral hand does. Hum Brain Mapp 31 1627-1642, 2010. (C) 2010 Wiley-Liss, Inc.

    DOI: 10.1002/hbm.20963

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  • Rapid oscillatory activity in delta brushes of premature and term neonatal EEG 査読

    Derrick W. S. Chan, Madoka Yamazaki, Tomoyuki Akiyama, Bill Chu, Elizabeth J. Donner, Hiroshi Otsubo

    BRAIN & DEVELOPMENT   32 ( 6 )   482 - 486   2010年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    We compared frequency and power of neonatal EEG delta brush rapid oscillatory activity (ROA) using multiple band frequency analysis (MBFA) in three groups; pre-term (PT, post-conceptional age 33-35.6 weeks, n = 5); full-term (FT, 39.4-40.6 weeks, n = 5) and pre-term or full-term with phenobarbital exposure (PB, n = 5). Mean number of delta brushes analyzed was 29.4 (range 26-47) in PT, 20.8 (14-33) in FT and 20 (7-37) in PB. Mean frequency +/- standard deviation (s.d.) was 16.9 +/- 2.1 Hz (range 15-20 Hz) in PT, 17.3 +/- 1.9 Hz (15-20 Hz) in FT and 16.1 +/- 1.6 Hz (14-19 Hz) in PB. Mean power +/- s.d. was 22.9 +/- 6.2 mu V(2) (range 16-39 mu V(2)) in PT, 11.9 +/- 4.1 mu V(2) (7-19 mu V(2)) in FT and 17.1 +/- 6.2 mu V(2) (9-26 mu V(2)) in PB. Power was significantly higher in PT than FT (p &lt; 0.005). Power after merging PB into respective PT (PT&apos;, n = 8) and FT (FT&apos;, n = 7) groups, remained significantly higher in PT&apos; (mean +/- s.d. 21.8 +/- 7.4 mu V(2)) than FT&apos; (11.4 +/- 3.6 mu V(2)) (p &lt; 0.05). We characterise ROA in delta brushes in maturing neonates using MBFA, which may provide additional information for assessing future seizure recurrence and epilepsy risk. (C) 2009 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.braindev.2009.07.006

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  • [Antiepileptic drugs in North America]. 査読

    Akiyama T, Otsubo H

    Brain and nerve = Shinkei kenkyu no shinpo   62 ( 5 )   519 - 526   2010年5月

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  • What is the point of specifying Panayiotopoulos syndrome from a practical point of view? 査読

    Eishi Asano, Tomoyuki Akiyama

    BRAIN & DEVELOPMENT   32 ( 1 )   2 - 3   2010年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.braindev.2009.10.003

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  • Localization of epileptic foci in children with intractable epilepsy secondary to multiple cortical tubers by using synthetic aperture magnetometry kurtosis Clinical article 査読

    Ichiro Sugiyama, Katsumi Imai, Yu Yamaguchi, Ayako Ochi, Yoko Akizuki, Cristina Go, Tomoyuki Akiyama, O. Carter Snead, Tames T. Rutka, James M. Drake, Elysa Widjaja, Sylvester H. Chuang, Doug Cheyne, Hiroshi Otsubo

    JOURNAL OF NEUROSURGERY-PEDIATRICS   4 ( 6 )   515 - 522   2009年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER ASSOC NEUROLOGICAL SURGEONS  

    Object. Magnetoencephalography (MEG) has been typically used to localize epileptic activity by modeling interictal activity as equivalent current dipoles (ECDs). Synthetic aperture magnetometry (SAM) is a recently developed adaptive spatial filtering algorithm for MEG that provides some advantages over the ECD approach. The SAM-kurtosis algorithm (also known as SAM[g2]) additionally provides automated temporal detection of spike sources by using excess kurtosis value (steepness of epileptic spike on virtual sensors). To evaluate the efficacy of the SAM(g2) method, the authors applied it to readings obtained in children with intractable epilepsy secondary to tuberous sclerosis complex (TSC), and compared them to localizations obtained with ECDs.
    Methods. The authors studied 13 children with TSC (7 girls) whose ages ranged from 13 months to 16.3 years (mean 7.3 years). Video electroencephalography, MR imaging, and MEG studies were analyzed. A single ECD model was applied to localize ECD clusters. The SAM(g2) value was calculated at each SAM(g2) virtual voxel in the patient&apos;s MR imaging-defined brain volume. The authors defined the epileptic voxels of SAM(g2) (evSAM[g2]) as those with local peak kurtosis values higher than half of the maximum. A clustering of ECDs had to contain a 6 ECDs within 1 cm of each other, and a grouping of evSAM(g2)s had to contain a 3 evSAM(g2)s within 1 cm of each other. The authors then compared both ECD clusters and evSAM(g2) groups with the resection area and correlated these data with seizure outcome.
    Results. Seizures started when patients were between 6 weeks and 8 years of age (median 6 months), and became intractable secondary to multiple tubers in all cases. Ictal onset on scalp video electroencephalography was lateralized in 8 patients (62%). The MEG studies showed multiple ECD clusters in 7 patients (54%). The SAM(g2) method showed multiple groups of epileptic voxels in 8 patients (62%). Colocalization of grouped evSAM(g2) with ECD clusters ranged from 20 to 100%, with a mean of 82%. Eight patients underwent resection of single (1 patient) and multiple (7 patients) lobes, with 6 patients achieving freedom from seizures. Of 8 patients who underwent surgery, in 7 the resection area covered ECD clusters and grouped evSAM(g2)s. In the remaining patient the resection area partially included the ECD cluster and grouped evSAM(g2)s. Six of the 7 patients became seizure free.
    Conclusions. The combination of SAM(g2) and ECD analyses succeeded in localizing the complex epileptic zones in children with TSC who had intractable epilepsy secondary to multiple cortical tubers. For the subset of children with TSC who present with early-onset and nonlateralized seizures, MEG studies in which SAM(g2) and ECD are used might identify suitable candidates for resection to control seizures. (DOI: 10.3171/2009.7.PEDS09198)

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  • High-frequency oscillations of ictal muscle activity and epileptogenic discharges on intracranial EEG in a temporal lobe epilepsy patient 査読

    Hiroshi Otsubo, Ayako Ochi, Katsumi Imai, Tomoyuki Akiyama, Ayataka Fujimoto, Cristina Go, Peter Dirks, Elizabeth J. Donner

    CLINICAL NEUROPHYSIOLOGY   119 ( 4 )   862 - 868   2008年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: During seizures, intracranial EEG electrodes can record ictal muscle movements. Our purpose was to differentiate the high-frequency oscillations (HFOs) of extracranial muscle contractions from those of intracranial epileptogenic discharges.
    Methods: Using intracranial video-EEG (IVEEG), we recorded seizures in a 17-year-old boy with left mesial-temporal lobe epilepsy. We used multiple band frequency analysis (MBFA) to differentiate extracranial HFOs of craniofacial muscle activities from intracranial HFOs recorded ictally and interictally.
    Results: During I I seizures, IVEEG showed low-amplitude fast waves (similar to 60 Hz) starting at the left mesial-temporal electrodes. Ictal facial grimacing projected low-amplitude (similar to 20 mu V) fast waves (similar to 160 Hz) on inferior lateral-temporal electrodes. Interictal chewing projected medium-amplitude (similar to 100 mu V) fast waves (similar to 140 Hz) correlating to mouth movements. MBFA topographic power spectrograms revealed a sustained, consistent ictal fast-frequency band from electrodes in the seizure-onset zone and randomly scattered HFOs without a specific frequency band from ictal and interictal extracranial muscle contractions.
    Conclusions: MBFA power spectrograms differentiated randomly scattered muscle HFOs without a specific frequency band at electrodes close to temporal muscles from ictal epileptic HFOs with a sustained, fast-frequency band in the seizure-onset zone.
    Significance: The pattern and distribution of frequency power spectrograms of extracranial HFOs differ from those of intracranial HFOs. (c) 2008 Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurophysiology.

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  • Epileptic spasms in older pediatric patients: MEG and ictal high-frequency oscillations suggest focal-onset seizures in a subset of epileptic spasms 査読

    Rajesh RamachandranNair, Ayako Ochi, Katsumi Imai, Mony Benifla, Tomoyuki Akiyama, Stephanie Holowka, James T. Rutka, O. Carter Snead, Hiroshi Otsubo

    EPILEPSY RESEARCH   78 ( 2-3 )   216 - 224   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Objectives: To elucidate the pathophysiology of intractable epileptic spasms in older children by describing the interictal. magnetoencephalography spike sources (MEGSSs), intracranial EEG ictal-onset zones (IOZs) and their ictal high-frequency oscillations (HFOs) and surgical outcomes.
    Methods: We studied five patients (4.5-14 years) who underwent surgery following intracranial video-EEG (VEEG) monitoring. We analyzed clinical profiles, MRIs, scalp and intracranial. VEEGs, and MEGSSs. We localized ictal. HFOs using a sampling rate of 1000 Hz and multiple band frequency analysis (MBFA).
    Results: Seizure onset ranged from 0.4 to 8 years. Three patients presented with asymmetrical spasms. Interictal scalp VEEG recorded predominantly unilateral epileptiform discharges in four; generalized and multifocal in one. Ictal. scalp VEEG showed generalized high-amplitude slow waves with superimposed fast waves in four patients; hemispheric electrodecremental episodes in one. MRI findings were normal in three, hemispheric polymicrogyria and periventricular heterotopia in one each. All. patients had unilateral MEGSS clusters. Ictal. HFOs, ranging from 150 to 250 Hz, localized over Rolandic and frontal regions in four, with one also having extensive temporo-occipital HFOs. After cortical resection, three patients were seizure free; one had &gt;90% reduction in seizure frequency. One patient experienced residual seizures after resection of the hemispheric ictal HFO region.
    Conclusion: Unilateral clusters of MEGSSs overlapped regional IOZs in older patients with epileptic spasms. High spatio-temporal MBFA before and during spasms revealed the regional ictal HFOs. Seizure-free outcomes following resection of zone with MEGSS clusters and ictal HFOs suggested that a subset of epileptic spasms was focal-onset seizures. (C) 2007 Elsevier B.V. All rights reserved.

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  • Dynamic changes of ictal high-frequency oscillations in neocortical epilepsy: Using multiple band frequency analysis 査読

    Ayako Ochi, Hiroshi Otsubo, Elizabeth J. Donner, Irene Elliott, Ryoichi Iwata, Takanori Funaki, Yoko Akizuki, Tomoyuki Akiyama, Katsumi Imai, James T. Rutka, O. Carter Snead

    EPILEPSIA   48 ( 2 )   286 - 296   2007年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    Purpose: To characterize the spatial and temporal course of ictal high-frequency oscillations (HFOs) recorded by subdural EEG in children with intractable neocortical epilepsy.
    Methods: We retrospectively studied nine children (four girls, five boys; 4-17 yr) who presented with intractable extrahippocampal localization-related epilepsy and who underwent extraoperative video subdural EEG (1000 Hz sampling rate) and cortical resection. We performed multiple band frequency analysis (MBFA) to evaluate the frequency, time course, and distribution of ictal HFOs. We compared ictal HFO changes before and after clinical onset and postsurgical seizure outcomes.
    Results: Seventy-eight of 79 seizures showed HFOs. We observed wide-band HFOs (similar to 250Hz, similar to 120 electrodes) in six patients either with partial seizures alone (three patients) or with epileptic spasms (three patients). Three patients with partial seizures that secondarily generalized had wide-band HFOs (similar to 170 Hz) before clinical onset and sustained narrow-band HFOs (60-164 Hz) with electrodecremental events after clinical onset (similar to 28 electrodes). In four postoperatively seizure-free patients, more electrodes recorded higher-frequency HFOs inside the resection area than outside before and after clinical seizure onset. In five patients with residual seizures, electrodes recorded more HFOs that were of higher or equal frequency outside the surgical area than inside after clinical onset.
    Conclusion: For partial seizures alone and epileptic spasms, more electrodes recorded only wide-band HFOs; for partial seizures that secondarily generalized, fewer electrodes recorded wide-band HFOs, but in these seizures electrodes also recorded subsequent sustained narrow-band ictal HFOs. Resection of those brain regions having electrodes with ictal, higher HFOs resulted in postsurgical seizure-free outcomes.

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  • Topographic movie of ictal high-frequency oscillations on the brain surface using subdural EEG in neocortical epilepsy 査読

    Tomoyuki Akiyama, Hiroshi Otsubo, Ayako Ochi, Elaine Z. Galicia, Shelly K. Weiss, Elizabeth J. Donner, James T. Rutka, O. Carter Snead

    EPILEPSIA   47 ( 11 )   1953 - 1957   2006年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    Purpose: To understand the rapid dynamic changes of ictal intracranial high-frequency oscillations (HFOs) in neocortical epilepsy.
    Methods: We integrated multiple band frequency analysis and brain-surface topographic maps of HFOs from ictal subdural EEG (SDEEG) recordings. We used SDEEG to record partial seizures consisting of right-arm jerks with secondary generalization in a 17-year-old right-handed girl. We selected 20-s EEG sections that included preclinical seizure recordings. We averaged the HFO power between 60 and 120 Hz for 25 selected electrodes, made topographic maps from these averaged powers, and superimposed the maps on the brain-surface image. We filmed consecutive HFO maps at a 10-ms frame rate.
    Results: Before clinical seizure onset, high-power HFOs emerged at the superior portion of the left precentral gyrus, then appeared in the middle of the left postcentral gyrus, and subsequently reverberated between both regions as well as the posterior portion of the left postcentral gyrus. Right-arm extension and facial grimacing started as the HFO power decreased. As generalized tonic-clonic seizures evolved, HFO power increased but remained within the central region.
    Conclusions: Topographic movies of intracranial HFOs on the brain surface allow visualization of the dynamic ictal changes in neocortical epilepsy.

    DOI: 10.1111/j.1528-1167.2006.00823.x

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  • Proposed diagnostic scheme for the classification of epileptic seizures and epilepsies (ILAE, 2001): Proposal from Japan Epilepsy Society 査読

    Kazuie Iinuma, Kiyoshi Morimoto, Tomoyuki Akiyama, Akio Ikeda, Mana Kurihara

    EPILEPSIA   47 ( 9 )   1588 - 1589   2006年9月

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    記述言語:英語   出版者・発行元:BLACKWELL PUBLISHING  

    DOI: 10.1111/j.1528-1167.2006.00843_5.x

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  • The mildest known case of Fukuyama-type congenital muscular dystrophy 査読

    Tomoyuki Akiyama, Yoko Ohtsuka, Tsutomu Takata, Junri Hattori, Yukiko Kawakita, Kayoko Saito

    BRAIN & DEVELOPMENT   28 ( 8 )   537 - 540   2006年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    We present a 14-year-old boy with Fukuyama-type congenital muscular dystrophy (FCMD) who shows the mildest muscle weakness ever reported with this affliction and exceptionally mild mental retardation, but who has intractable epilepsy. Magnetic resonance imaging showed the typical abnormalities of FCMD. Molecular genetic analyses revealed a 3 kb insertion mutation in the fukutin gene heterozygously. We could find no mutation in the coding region of the fukutin gene in the chromosome without a 3 kb insertion. The most probable mechanism of clinical manifestation in this patient could be either a mutation in the noncoding regions of the fukutin gene on the chromosome without the ancestral founder haplotype of FCMD, or an error in the process of transcription or translation. Another possibility is the abnormalities in other genes involved in the glycosylation of alpha-dystroglycan, such as Fukutin-related protein and LARGE genes. (c) 2006 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.braindev.2006.02.003

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  • A population-based survey of childhood epilepsy in Okayama Prefecture, Japan: Reclassification by a newly proposed diagnostic scheme of epilepsies in 2001 査読

    Tomoyuki Akiyama, Katsuhiro Kobayashi, Tatsuya Ogino, Harumi Yoshinaga, Eiji Oka, Makio Oka, Minako Ito, Yoko Ohtsuka

    EPILEPSY RESEARCH   70   S34 - S40   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The purpose of this study is to clarify the usefulness and problems of the newly proposed classification of epilepsies (International League Against Epilepsy: ILAE, 2001) in the epidemiological studies of epilepsy.
    We previously conducted an epidemiological study in Okayama Prefecture, Japan, in 1999, using the ILAE 1989 classification. Among 250,997 children under 13 years of age, 2220 epileptic patients were ascertained. In this study, we reclassified them according to the ILAE 2001 classification, focusing on axes 2 (seizure types) and 3 (syndromes).
    We were able to classify 1803 (95.0%) seizure types out of 1899 with detailed clinical information. In focal seizures, the most common were secondarily generalized seizures (88.6%), which generally do not represent a unique anatomic substrate. In generalized seizures, topic-clonic seizures (40.7%) and spasms (21.0%) were the most common. We identified only 269 (12.1%) patients with specific epilepsy syndromes out of the 2220. We classified 1761 patients without specific syndromic diagnoses only by axis 2, but the new concept of epileptic seizure types, representing a unique pathophysiologic mechanism and anatomic substrate, was not very meaningful in most cases, even in those with focal seizures. (c) 2006 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.eplepsyres.2005.11.017

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  • EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome 査読

    K Kikumoto, H Yoshinaga, M Oka, M Ito, F Endoh, T Akiyama, Y Ohtsuka

    EPILEPTIC DISORDERS   8 ( 1 )   53 - 56   2006年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JOHN LIBBEY EUROTEXT LTD  

    We report on a 4-year 8-month-old boy with Panayiotopoulos syndrome who showed atypical evolution with newly developed absence seizures and EEG exacerbation induced by carbamazepine. Soon after the introduction of carbamazepine, EEGs began to worsen, and finally absence seizures and myoclonic seizures appeared. Immediately after we discontinued carbamazepine, the seizures disappeared and the EEG improved. Carbamazepine may induce unusual electroclinical features, electrophysiologically explained by bilateral synchrony. This case provides more evidence of the close links between Panayiotopoulos syndrome and benign childhood epilepsy with centrotemporal spikes.

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  • Partial seizures triggering infantile spasms in the presence of a basal ganglia glioma 査読

    R RamachandranNair, A Ochi, T Akiyama, DJ Buckley, TB Soman, SK Weiss, H Otsubo

    EPILEPTIC DISORDERS   7 ( 4 )   378 - 382   2005年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JOHN LIBBEY EUROTEXT LTD  

    Infantile spasms associated with brain tumors have been reported. A focal cortical lesion can induce infantile spasms by triggering the brainstem and basal ganglia in this vulnerable age group. We report the case of a female infant with a low-grade glioma in the right basal ganglia, spreading to the cortical area. She presented at the age of five months with left hemiparesis and partial seizures. She developed infantile spasms at the age of 12 months. This is the first video clip report of partial seizures triggering symmetrical spasms in series, secondary to a basal ganglia glioma extending to the cortex.

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  • Focal cortical high-frequency oscillations trigger epileptic spasms: Confirmation by digital video subdural EEG 査読

    T Akiyama, H Otsubo, A Ochi, T Ishiguro, G Kadokura, R RamachandranNair, SK Weiss, JT Rutka, O Snead

    CLINICAL NEUROPHYSIOLOGY   116 ( 12 )   2819 - 2825   2005年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: To localize high-frequency oscillations (HFOs) on the cortex during epileptic spasms using video subdural EEG and Multiple Band Frequency Analysis (MBFA).
    Methods: Using video subdural EEG sampled at 1 kHz, we studied a 14-year-old boy with asymmetric epileptic spasms of possible left frontal origin. We identified HFOs, then analyzed and localized their distributions by MBFA. We correlated HFO distribution to clinical spasm intensity.
    Results: Ictal subdural EEG recorded HFOs at 60-150 Hz lasting 0.3-4 s. MBFA showed extensive but noncontiguous distribution of HFOs predominantly over the left frontal and temporal regions. HFOs began and became quasiperiodic before manifestation of clinical spasms. As clinical spasms intensified, HFOs persisted in regions where they initiated subclinically but were of higher frequency and greater power than HFOs in other regions. We performed cortical resections over the left frontal and temporal regions with predominant HFOs. Six months after surgery, the patient remained seizure free.
    Conclusions: HFOs were present over the ictal onset zone during epileptic spasms. Periodic spasms in this patient had the characteristics of partial seizures.
    Significance: We show that HFOs occurred over the cerebral cortex during epileptic spasms, and we suggest that these focal cortical HFOs triggered the spasms. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.clinph.2005.08.029

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  • Kinesigenic attacks with ictal electroencephalographic abnormalities 査読

    T Akiyama, Y Ohtsuka, K Kobayashi, E Oka

    PEDIATRIC NEUROLOGY   31 ( 5 )   357 - 359   2004年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    We report on a 14-year 5-month-old male who had attacks similar to those of paroxysmal kinesigenic choreoathetosis. The attacks were elicited exclusively by sudden movements. On several occasions, these attacks were immediately followed by loss of consciousness or a seizure. Ictal electroencephalograms of his attacks without loss of consciousness or a seizure indicated 1.5-3.0 Hz activity in the left hemisphere. A small dosage of carbamazepine was remarkably effective in stopping the attacks. This case demonstrates that a thorough ictal electroencephalographic examination is indispensable for clarifying the pathophysiology of kinesigenic attacks. The relationship between paroxysmal kinesigenic choreoathetosis and supplementary motor area seizures is also discussed. (C) 2004 by Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.pediatrneurol.2004.05.006

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  • Very fast rhythmic activity on scalp EEG associated with epileptic spasms 査読

    K Kobayashi, M Oka, T Akiyama, T Inoue, K Abiru, T Ogino, H Yoshinaga, Y Ohtsuka, E Oka

    EPILEPSIA   45 ( 5 )   488 - 496   2004年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING INC  

    Purpose: Very fast activity was investigated on the ictal EEGs of epileptic spasms to elucidate the pathophysiology of West syndrome (WS) and related disorders from a novel point of view.
    Methods: The traces of scalp ictal EEG of spasms temporally were expanded in 11 patients whose clinical diagnosis was symptomatic WS in six, cryptogenic WS in two, Aicardi syndrome in one, and symptomatic generalized epilepsy after WS in the remaining two. Time evolution of averaged power spectra of the ictal fast activity also was analyzed in each patient.
    Results: Rhythmic gamma activity with frequency ranging from 50 to 100 Hz was detected in a total of 345 of 537 spasms. Fast activity was seen bilaterally in nine patients, was lateralized to one hemisphere in another, and appeared independently on each hemisphere in the remaining infant with Aicardi syndrome. Power spectra showed a clear peak corresponding to spasm-associated gamma rhythm, with frequency centering similar to65 Hz and ranging from 51 to 98 Hz. The morphology and spectral characteristics of ictal gamma rhythm were completely different from those of muscle activity or alternating current (AC) artifacts.
    Conclusions: Spasm-associated gamma activity was clearly detected on the scalp. This observation may provide a clue to the pathophysiology of spasms.

    DOI: 10.1111/j.0013-9580.2004.45703.x

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  • A study of spike-density on EEG in West syndrome 査読

    M Oka, K Kobayashi, T Akiyama, T Ogino, E Oka

    BRAIN & DEVELOPMENT   26 ( 2 )   105 - 112   2004年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    To elucidate the pathophysiology of spasms in series, the distribution and density of spikes on hypsarrhythmia were studied in 13 patients with West syndrome by excluding slow waves from EEG using a digital filter. (1) Interictal spikes were mostly multifocal and dominant over the bilateral posterior head area with very few diffuse discharges. Therefore, spikes on hypsarrhythmia were demonstrated to occur actually depending on the brain regions although they appeared random. (2) The dominant region of interictal spikes did not correspond to the underlying focal cortical lesion in many patients, and was indicated to reflect the general process of cerebral maturation in infancy. (3) There were far fewer inter-spasm spikes, especially during the middle phase of a series of spasms, than interictal spikes. It was implied that the cortical activity of hypsarrhythmia was interfered with by the abnormal subcortical function, which might be related to the generation of spasms. (4) The dominant region of inter-spasm spikes tended to coincide with a focal cortical lesion shown by MRI and the focus of associated partial seizures. (C) 2003 Elsevier B.V. All rights reserved.

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  • Initiation of treatment and selection of antiepileptic drugs in childhood epilepsy 査読

    E Oka, T Murakami, T Ogino, T Kobayashi, Ohmori, I, T Akiyama, M Ito

    EPILEPSIA   45   17 - 19   2004年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Purpose: A retrospective study was carried out on 53 cases with childhood epilepsy to evaluate the validity of the initial selection of antiepileptic drug (AED).
    Methods: We investigated the AEDs selected at the beginning of the treatment from the medical records of 53 untreated cases. A follow-up study was undertaken to evaluate the effects of the AEDs. In the second study, we investigated the AEDs of 10 cases with atypical benign partial epilepsy (ABPE), to clarify whether the initial AEDs selected for rolandic epilepsy were related to the appearance of ABPE.
    Results: The AEDs used at the initial stage consisted of carbamazepine (CBZ), valproic acid (VPA), phenobarbital (PB), and vitamin B-6. The main AEDs were CBZ and VPA for localization-related epilepsy, and VPA for generalized epilepsy. The initial selection of AEDs in 41 (85.4%) of 48 cases treated with AEDs were considered to be correct from the results of follow-up. We could not specify any AEDs that related to the appearance of ABPE.
    Conclusions: The selection of AED in this series was considered to be most appropriate. We proposed a criterion to determine whether to begin the AED treatment immediately at the initial seizure.

    DOI: 10.1111/j.0013-9580.2004.458004.x

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  • Systematic source estimation of spikes by a combination of independent component analysis and RAP-MUSIC II: Preliminary clinical application 査読

    K Kobayashi, T Akiyama, T Nakahori, H Yoshinaga, J Gotman

    CLINICAL NEUROPHYSIOLOGY   113 ( 5 )   725 - 734   2002年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    Objectives: We tried to estimate epileptic sources by a combination of independent component analysis (ICA) and recursively applied and projected multiple signal classification (RAP-MUSIC) in real epileptiform EEG discharges.
    Methods: EEG data including an array of spikes from 3 patients were decomposed by ICA, and source estimation was performed by applying RAP-MUSIC to the spatial information defined by the set of ICA components that showed epileptiform activity in their waveform. Sources were also estimated from the same data using RAP-MUSIC based on eigen-decomposition of the covariance matrix of averaged spikes, and common spatial pattern decomposition for comparison.
    Results: RAP-MUSIC based on ICA could estimate generally correct epileptic sources in the 3 patients, and its results were better than those of the other methods, when compared to intracerebral data. The present analysis proceeded without introduction of subjective decision after data selection. The separation of epileptiform discharges from the background is essential for this analysis, and was successfully performed in the real EEG data.
    Conclusions: RAP-MUSIC based on ICA appears promising for estimation of epileptic sources with minimal dependence on subjective decisions in the process of analysis. In particular, it was not necessary to select the number of sources. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

    DOI: 10.1016/S1388-2457(02)00047-0

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  • Systematic source estimation of spikes by a combination of independent component analysis and RAP-MUSIC I: Principles and simulation study 査読

    K Kobayashi, T Akiyama, T Nakahori, H Yoshinaga, J Gotman

    CLINICAL NEUROPHYSIOLOGY   113 ( 5 )   713 - 724   2002年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    Objectives: We propose a combination of independent component analysis (ICA) and recursively applied and projected multiple signal classification (RAP-MUSIC) as a new approach to dipole source estimation of epileptiform discharges. The method is minimally dependent on subjective decisions.
    Methods: Ten electroencephalographic (EEG) data matrices were generated by computer, each matrix including real background activity from a normal subject and an array of added simulated spikes. Each spike was a summation of two transients originating from slightly different 'original dipole sources'. The unaveraged EEG matrices were decomposed by ICA, and source estimation was performed by applying RAP-MUSIC to the spatial information defined by the ICA components showing epileptiform activity in their waveform. For comparison, dipoles were also estimated from the same matrices using two existing methods: RAP-MUSIC based on eigen-decomposition of the covariance matrices of averaged spikes and common spatial pattern decomposition.
    Results: In every simulated EEG data matrix, two dipoles close to the original sources were estimated by the present method. Their unaveraged activities were also similar to those of the original sources. The two existing methods gave less precise results than the proposed method.
    Conclusions: RAP-MUSIC based on ICA thus proved promising for source estimation of unaveraged epileptiform discharges. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

    DOI: 10.1016/S1388-2457(02)00046-9

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  • Source estimation of spikes by a combination of independent component analysis and RAP-MUSIC 査読

    Katsuhiro Kobayashi, Tomoyuki Akiyama, Tomoyuki Nakahori, Harumi Yoshinaga, Yoko Ohtsuka, Jean Gotman, Eiji Oka

    International Congress Series   1232 ( C )   311 - 316   2002年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We designed a combination of independent component analysis (ICA) and recursively applied and projected multiple signal classification (RAP-MUSIC) as a new approach to dipole source estimation of epileptiform discharges. The estimation is minimally influenced by subjective decisions in this analysis. A simulation study was performed by generating 10 EEG data matrices by means of a computer: each matrix included real background activity from a normal subject to which an array of simulated unaveraged spikes was added. Each discharge was a summation of two transients originating from slightly different “original dipole sources”. The simulated spikes in the unaveraged EEG data were extracted from the background by ICA as spatiotemporal components, each component having fixed potential field distribution and maximally independent waveform. The complete separation between spikes and background was objectively proven by reconstruction of the EEG from the decomposed components. RAP-MUSIC was performed based on the spatial information included in the epileptic ICA components. RAP-MUSIC does not involve subjective decisions such as selection of multiple local score peaks, determination of the number of dipoles or initial guesses of dipole parameters. In every simulated EEG data matrix, two dipoles close to the original sources were estimated. Their activities were also similar to those of the original sources. For comparison, the same simulated EEG data were averaged and subjected to RAP-MUSIC using eigen-decomposition of the covariance matrices. Only one dipole was estimated in every simulation by this conventional method and therefore the result of the present method was better. RAP-MUSIC based on ICA, thus, proved promising for source estimation of unaveraged epileptiform discharges. © 2002, Elsevier B.V.

    DOI: 10.1016/S0531-5131(01)00713-0

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  • Photosensitive fits elicited by TV animation: An electroencephalographic study 査読

    Hideo Enoki, Tomoyuki Akiyama, Junri Hattori, E. D.I. Oka

    Pediatrics International   40 ( 6 )   626 - 630   1998年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: We carried out a clinical and electroencephalographic (EEG) study to reveal the pathophysiology of acute symptoms elicited by a TV animation program. Methods: Clinical data and EEG were obtained from 20 patients ranging in age from 6 to 30 years. A pattern presentation and an intermittent photic stimulation were performed. Results: Of 20 patients, 13 had a convulsion and seven had other symptoms, mainly nausea and/or vomiting. A photoparoxysmal response (PPR) was confirmed in 12 of 13 patients (92.3%) who had a convulsion. Only one of seven patients (14.3%) without a convulsion showed a PPR. The incidence of PPR was significantly higher in patients with convulsion than those without convulsion. There were no significant differences in the family history of convulsion, gender, parameters associated with TV watching and basic EEG between the two groups. All patients with PPR had a convulsion or consciousness disturbance. Conclusion: Acute symptoms, such as convulsion and impairment of consciousness, are supposed to be based on photosensitivity. © 1998 Wiley. All rights reserved.

    DOI: 10.1111/j.1442-200X.1998.tb02005.x

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  • Electroclinical study of localization-related epilepsies in early infancy 査読

    Ohmori, I, Y Ohtsuka, E Oka, T Akiyama, S Ohtahara

    PEDIATRIC NEUROLOGY   16 ( 2 )   131 - 136   1997年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    To clarify the characteristics of localization-related epilepsies in early infancy, we performed an electroclinical study of 28 epileptic patients whose first seizures occurred before 6 months of age. The patients were retrospectively divided into two groups: the seizure-controlled group (8 patients) and the refractory group (20 patients). The seizure-controlled group included the patients whose seizures were suppressed within 1 year after onset; the refractory group included all other patients. The characteristics of the refractory group were as follows: (1) most patients had serious underlying pathologies; (2) the seizure type in most cases was simple partial seizure or complex partial seizure without secondary generalization; (3) the interictal EEG showed focal abnormalities and severe dysrhythmia on the basic pattern associated with multifocal spikes in most cases; and (4) in some patients, West syndrome developed after localization- related epilepsies and generalized seizures appeared later in some cases. (C) 1997 by Elsevier Science Inc.

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書籍等出版物

  • 読んでみよう! デジタル脳波 ハンズオンによる小児脳波判読の手引き

    秋山 倫之( 担当: 単著)

    洋學社  2018年9月  ( ISBN:490829612X

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    総ページ数:178  

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MISC

  • ACTH療法中に尿路結石を生じた乳幼児例における尿沈渣所見の経時的変化

    宮原 宏幸, 水野 むつみ, 兵頭 勇紀, 西本 静香, 花岡 義行, 松田 奈央子, 金 聖泰, 柴田 敬, 遠藤 文香, 秋山 麻里, 岡 牧郎, 秋山 倫之, 小林 勝弘, 塚原 宏一

    日本小児科学会雑誌   123 ( 7 )   1199 - 1199   2019年7月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • ALDH7A1の複合ヘテロ変異が同定できたビタミン依存性てんかんの1例

    柳下 友映, 山本 圭子, 小池 敬義, 那須 裕郷, 高橋 幸利, 秋山 倫之, 永田 智, 山本 俊至

    日本遺伝カウンセリング学会誌   40 ( 2 )   96 - 96   2019年7月

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    記述言語:日本語   出版者・発行元:日本遺伝カウンセリング学会  

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  • 里吉病の1例

    兵頭 勇紀, 秋山 麻里, 秋山 倫之, 平井 陽至, 小林 勝弘

    日本小児科学会雑誌   123 ( 7 )   1198 - 1199   2019年7月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • アジア各国における診療の多様性-West症候群のstandard therapyについて- 日本におけるWest症候群の標準的治療(Standard therapy for West syndrome in Japan)

    秋山 倫之

    脳と発達   51 ( Suppl. )   S156 - S156   2019年5月

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    記述言語:英語   出版者・発行元:(一社)日本小児神経学会  

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  • はじめて小児神経学を学ぶ人のための実践教育セミナー てんかんの診断と治療

    秋山 倫之

    脳と発達   51 ( Suppl. )   S193 - S193   2019年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 急性脳炎・脳症-これからの診断と治療- 急性脳炎・脳症における代謝物分析

    秋山 倫之

    脳と発達   51 ( Suppl. )   S100 - S100   2019年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 小児急性脳炎・脳症におけるメタボローム解析

    秋山 倫之

    脳と発達   51 ( 2 )   118 - 118   2019年3月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • てんかんの治療Update 新規抗てんかん薬の使い方 エキスパートオピニオン てんかん症候群における新規抗てんかん薬の使い方

    秋山 倫之

    脳と発達   51 ( 2 )   90 - 90   2019年3月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • てんかんの治療Update 新規抗てんかん薬の使い方 エキスパートオピニオン てんかん症候群における新規抗てんかん薬の使い方

    秋山 倫之

    脳と発達   51 ( 2 )   101 - 105   2019年3月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

    過去十数年において新たな抗てんかん薬が次々と使用可能になったが、選択に悩む機会も同時に増えた。新規抗てんかん薬の中では、副作用が比較的少なく治療スペクトルの広いlevetiracetam、lamotrigine、次いでperampanelが有用な選択肢と思われる。Topiramateは副作用が多めではあるが、種々の発作型に対しての有効性は高い。VigabatrinはWest症候群、rufinamideはLennox-Gastaut症候群、stiripentolはDravet症候群に特化した治療薬である。Lacosamideは、levetiracetamやtopiramateと並び、睡眠時持続性棘徐波を示すてんかん性脳症の新たな治療選択肢になる可能性がある。新旧薬剤の特徴を熟知し、上手に選んで使用することが肝要である。(著者抄録)

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  • 非典型的な臨床像を呈したDYT-TOR1Aの一卵性双胎例

    花岡 義行, 秋山 倫之, 秋山 麻里, 岡 牧郎, 遠藤 文香, 柴田 敬, 小林 勝弘

    日本小児科学会雑誌   123 ( 2 )   328 - 328   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • 臨床研究・症例報告 ムクナ豆服用で7歳からの日内変動を伴う歩行障害が消失した瀬川病の11歳女児

    徐 悦, 石黒 精, 秋山 倫之, 新宅 治夫, 久保田 雅也

    小児科臨床 = Japanese journal of pediatrics   72 ( 1 )   89 - 93   2019年1月

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    記述言語:日本語   出版者・発行元:日本小児医事出版社  

    瀬川病は、GTPシクロヒドロラーゼの機能低下(CGH-1遺伝子異常)に起因する小児期発症の日内変動を伴うジストニアを特徴とする常染色体優性遺伝疾患である。L-dopaが有効であり、その効果は生涯にわたってほぼ持続する。ムクナ豆は、L-dopaを豊富に含む亜熱帯に多い豆科の食物であり、Parkinson病に対する有効性は小規模の臨床研究で証明され、Parkinson病モデル動物でも有効性と高い生物学的利用能が示唆されている。本症例は、7歳から日内変動を伴う歩行障害を主訴に受診し、瀬川病の確定診断に至った11歳女児が、家族の希望によるムクナ豆服用後にジストニア症状が完全に消失した1例である。瀬川病に対するムクナ豆の効果は、家族による使用経験の報告はあるものの、論文で報告されたものはない。今後の瀬川病における臨床応用には、薬物動態の精査やL-dopa投与例との比較が必要である。(著者抄録)

    CiNii Article

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  • 脳葉酸欠乏症を合併し、folinic acidで治療しているミトコンドリア病の1例

    兵頭 勇紀, 秋山 麻里, 秋山 倫之, 小林 勝弘

    脳と発達   50 ( 6 )   444 - 444   2018年11月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 小児てんかんのミオクロニー発作の頭皮発作時脳波における速波(40-150 Hz)振動の検出

    小林 勝弘, 大内 勇児, 柴田 敬, 花岡 義行, 秋山 麻里, 岡 牧郎, 遠藤 文香, 秋山 倫之

    臨床神経生理学   46 ( 5 )   494 - 494   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

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  • ペランパネルが発作と異常行動に共に著効したLennox-Gastaut症候群の1例

    松田 奈央子, 遠藤 文香, 秋山 倫之, 小林 勝弘

    臨床神経生理学   46 ( 5 )   431 - 431   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

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  • 髄液中ピリドキサールリン酸とてんかんとの関連性についての検討

    金 聖泰, 秋山 倫之, 兵頭 勇紀, 松田 奈央子, 水野 むつみ, 西本 静香, 小林 勝弘

    てんかん研究   36 ( 2 )   478 - 478   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 本邦におけるピリドキシン依存性てんかん診断システムの開発

    秋山 倫之, 大星 大観, 今井 克美, 道和 百合, 椎原 隆, 福山 哲広, 兵頭 勇紀, 土屋 弘樹, 久保田 雅也, 浜野 晋一郎, 岡西 徹, 小林 勝弘

    てんかん研究   36 ( 2 )   479 - 479   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • West症候群および類縁病型の新たな治療戦略における活性型ビタミンB6の有効性の検討

    花岡 義行, 秋山 倫之, 岡 牧郎, 遠藤 文香, 秋山 麻里, 金 聖泰, 西本 静香, 兵頭 勇紀, 小林 勝弘

    てんかん研究   36 ( 2 )   460 - 460   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • てんかんの原因となる先天性代謝疾患の診断に対する当院の取り組み

    秋山 倫之, 秋山 麻里, 林 裕美子, 柴田 敬, 花岡 義行, 吉永 治美, 小林 勝弘

    てんかん研究   36 ( 1 )   74 - 74   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 病巣切除により発作抑制が得られた乳児結節性硬化症の2例

    佐々木 達也, 上利 崇, 西本 静香, 秋山 麻里, 遠藤 文香, 岡 牧郎, 秋山 倫之, 小林 勝弘, 伊達 勲

    てんかん研究   36 ( 1 )   76 - 76   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • GABRA1遺伝子異常を認めた難治てんかんの一例

    柴田 敬, 竹内 章人, 秋山 麻里, 岡 牧郎, 遠藤 文香, 秋山 倫之, 山本 俊至, 小林 勝弘

    てんかん研究   36 ( 1 )   84 - 85   2018年6月

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  • 小児けいれん性疾患における活性型ビタミンB6の有用性

    花岡 義行, 吉永 治美, 秋山 倫之, 柴田 敬, 小林 勝弘

    てんかん研究   36 ( 1 )   67 - 67   2018年6月

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  • 高周波律動(HFO)解析により切除範囲を決定した前頭葉てんかんの1例

    上利 崇, 秋山 倫之, 林 裕美子, 岡 牧郎, 佐々木 達也, 新光 阿以子, 吉永 治美, 伊達 勲

    てんかん研究   36 ( 1 )   70 - 71   2018年6月

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  • ビガバトリンの位置づけ

    秋山 倫之

    脳と発達   50 ( Suppl. )   S201 - S201   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 小児期脳炎・脳症患者における急性期脳波の重症度と予後の関連

    秋山 麻里, 岡 牧郎, 遠藤 文香, 秋山 倫之, 小林 勝弘

    脳と発達   50 ( Suppl. )   S325 - S325   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 小児期の睡眠時頭皮脳波の棘波に伴う高周波振動の追跡研究

    大内 勇児, 秋山 倫之, 兵頭 勇紀, 土屋 弘樹, 花岡 義行, 柴田 敬, 秋山 麻里, 遠藤 文香, 岡 牧郎, 小林 勝弘

    脳と発達   50 ( Suppl. )   S333 - S333   2018年5月

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  • West症候群を発症し、Vitamin B6大量療法が奏効したKlinefelter症候群の6ヵ月男児例

    大山 宜孝, 中野 晃太郎, 伊藤 萌, 秋山 倫之, 武下 草生子, 波多野 道弘, 岩本 眞理

    脳と発達   50 ( Suppl. )   S383 - S383   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 小児急性脳炎・脳症におけるメタボローム解析

    秋山 倫之

    脳と発達   50 ( Suppl. )   S216 - S216   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • West症候群に対するビガバトリンの使用経験

    柴田 敬, 秋山 麻里, 松田 奈央子, 兵頭 勇紀, 土屋 弘樹, 花岡 義行, 遠藤 文香, 秋山 倫之, 小林 勝弘

    脳と発達   50 ( Suppl. )   S295 - S295   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • てんかんを合併した結節性硬化症児の幼児期の発達について

    遠藤 文香, 土屋 弘樹, 兵頭 勇紀, 秋山 麻里, 岡 牧郎, 秋山 倫之, 吉永 治美, 小林 勝弘

    脳と発達   50 ( Suppl. )   S305 - S305   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • てんかんの治療Update:新規抗てんかん薬の使い方 エキスパートオピニオン てんかん症候群における新規抗てんかん薬の使い方

    秋山 倫之

    脳と発達   50 ( Suppl. )   S163 - S163   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 痙攣重積で脳症を繰り返すクレアチン欠乏症(GAMT欠損症)の1例

    田畑 昌子, 田淵 剛, 東 靖人, 秋山 倫之

    臨床神経学   58 ( 4 )   273 - 273   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • FAST (40-150 HZ) OSCILLATIONS ARE ASSOCIATED WITH POSITIVE SLOW WAVES IN THE SCALP ICTAL EEGS OF EPILEPTIC SPASMS IN WEST SYNDROME

    K. Kobayashi, T. Akiyama, M. Oka, F. Endoh, M. Akiyama, T. Shibata, Y. Hanaoka, H. Yoshinaga

    EPILEPSIA   58   S77 - S77   2017年12月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY  

    Web of Science

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  • 【デジタル脳波の新しい展開】Wide band EEGの有用性(HFO)

    秋山 倫之

    臨床神経生理学   45 ( 6 )   525 - 531   2017年12月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

    高周波振動(HFO)は、γ帯域を超える80Hz以上の脳波活動である。HFOの記録には、サンプリング周波数2kHz以上、アンチエイジングフィルタ600Hz以上が推奨される。HFOは、臨床用途の電極を用いて記録できる。HFOの検出には、低域遮断フィルタを用い、感度を上げ、タイムスケールを引き延ばして判読する。頭蓋内脳波での発作間欠時HFOは、発作開始領域やてんかん原性領域の局在を示唆する。頭蓋内脳波での発作開始時HFOもてんかん外科の手術成績改善に有用な可能性がある。小児てんかん性脳症では、頭皮上脳波で発作間欠時HFOが多数出現しており、認知機能障害への関与が推測されている。てんかん原性に関連する病的HFOを認知に関連する生理的HFOから区別する手がかりとして、てんかん性棘波をともなうか否か、徐波成分とのカップリング様式の相違、レム睡眠における出現頻度の変化の相違などが報告されている。(著者抄録)

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  • 【尿毒症とグアニジノ化合物-機能性小分子研究の歴史と新たな展開-】神経とグアニジノ化合物 クレアチン合成障害(AGAT欠損、GAMT欠損)による中枢神経疾患

    秋山 倫之

    腎と透析   83 ( 別冊 尿毒症とグアニジノ化合物-機能性小分子研究の歴史と新たな展開- )   74 - 79   2017年9月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 尿中メタボローム解析により偶発的に発見されたジヒドロピリミジナーゼ欠損症の1例

    土屋 弘樹, 秋山 倫之, 久原 とみ子, 中島 葉子, 柴田 敬, 秋山 麻里, 岡 牧郎, 遠藤 文香, 吉永 治美, 小林 勝弘

    日本先天代謝異常学会雑誌   33   228 - 228   2017年9月

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    記述言語:日本語   出版者・発行元:日本先天代謝異常学会  

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  • けいれん重積型(二相性)急性脳症(AESD)後にepileptic spasmを発症した症例の検討

    兵頭 勇紀, 秋山 麻里, 花岡 義行, 柴田 敬, 岡 牧郎, 秋山 倫之, 小林 勝弘

    てんかん研究   35 ( 2 )   454 - 454   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 難治てんかんにおけるペランパネルの有効性について

    遠藤 文香, 水野 むつみ, 松田 奈央子, 大内 勇児, 秋山 倫之, 小林 勝弘

    てんかん研究   35 ( 2 )   485 - 485   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 早期手術を行い発作抑制が得られた乳児結節性硬化症の2例

    佐々木 達也, 上利 崇, 西本 静香, 秋山 麻里, 遠藤 文香, 岡 牧郎, 秋山 倫之, 小林 勝弘, 伊達 勲

    てんかん研究   35 ( 2 )   588 - 588   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • ビタミンB6が著効したWest症候群の一例

    西村 洋子, 板倉 文子, 岡崎 哲也, 斎藤 義朗, 秋山 倫之, 前垣 義弘

    てんかん研究   35 ( 2 )   637 - 637   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • てんかん性脳症

    秋山 倫之

    てんかん研究   35 ( 2 )   343 - 344   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 治せるてんかんを見逃さない ビタミンB6とてんかん

    花岡 義行, 秋山 倫之

    てんかん研究   35 ( 2 )   402 - 403   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 特異な経過をたどったPROSC遺伝子変異を有するビタミンB6依存性てんかんの1例

    武下 草生子, 渡辺 好宏, 藤原 祐, 蒲 ひかり, 岡西 徹, 金井 創太郎, 本井 宏尚, 榎 日出夫, 藤本 礼尚, 秋山 倫之, 中島 光子, 才津 浩智, 松本 直通

    てんかん研究   35 ( 2 )   444 - 444   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 結節性硬化症の乳児期におけるてんかんの特徴

    土屋 弘樹, 遠藤 文香, 岡 牧郎, 花岡 義行, 柴田 敬, 林 裕美子, 秋山 麻里, 秋山 倫之, 吉永 治美, 小林 勝弘

    てんかん研究   35 ( 2 )   453 - 453   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 結節性硬化症の乳児期における中枢神経系の画像変化

    土屋 弘樹, 遠藤 文香, 岡 牧郎, 秋山 倫之, 吉永 治美, 小林 勝弘

    日本小児科学会雑誌   121 ( 8 )   1443 - 1443   2017年8月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • けいれん重積状態に対する評価

    秋山 倫之, 前垣 義弘

    脳と発達   49 ( Suppl. )   S226 - S226   2017年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 髄液中モノアミン類と5-メチルテトラヒドロ葉酸の同時測定法の開発(Simultaneous measurement of monoamines and 5-methyltetrahydrofolate in the cerebrospinal fluid)

    秋山 倫之, 林 裕美子, 花岡 義行, 柴田 敬, 秋山 麻里, 中村 和幸, 露崎 悠, 久保田 雅也, 遠山 潤, 吉永 治美, 小林 勝弘

    脳と発達   49 ( Suppl. )   S334 - S334   2017年5月

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    記述言語:英語   出版者・発行元:(一社)日本小児神経学会  

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  • 小児神経科医と希少疾病 ビタミンB6依存性てんかん

    秋山 倫之

    脳と発達   49 ( Suppl. )   S258 - S258   2017年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 結節性硬化症の乳児期における中枢神経症状の展開

    土屋 弘樹, 岡 牧郎, 花岡 義行, 柴田 敬, 林 裕美子, 秋山 麻里, 遠藤 文香, 秋山 倫之, 吉永 治美, 小林 勝弘

    日本小児科学会雑誌   121 ( 2 )   257 - 257   2017年2月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • 結節性硬化症における多臓器フォローアップの実態

    吉永 治美, 岡 牧郎, 秋山 倫之, 遠藤 文香, 秋山 麻里, 林 裕美子, 柴田 敬, 花岡 義行, 小林 勝弘

    脳と発達   49 ( 1 )   5 - 9   2017年1月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

    【目的】結節性硬化症(TSC)は多臓器に過誤組織を発生する疾患である。したがって多くの診療科が協力して診療に当たる必要がある。そこで、その実態を把握するために以下の検討を行った。【方法】対象は岡山大学病院小児神経科を受診したTSC症例のうち複数年にわたって来院歴のある38例とした。各臓器のフォローアップ状況を小児群と成人群に分けて後方視的に検討した。【結果】小児期には比較的どの臓器も確実にフォローが行われていた。成人群では脳の画像のフォローは上衣下巨星細胞腫(SEGA)のある症例も含めて不完全であった。腎臓は、成人群では異常のあった7例においても5年以上フォローがされていなかった。肺はリンパ脈管筋腫(LAM)の合併率の高くなる18歳以上の女性においても検査率は50%であった。心臓は小児群では横紋筋腫のある12例中10例が1〜3年ごとのエコー検査を受けていたが、一方で伝導障害に関しての心電図の施行は全年齢でおろそかであった。【結論】欧米でのガイドラインに照らし合わせてみると、フォローアップ体制は特に成人群において不完全であることが明らかとなった。TSCボードなどの多数科の医療連携体制の場が必要と考えられた。(著者抄録)

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  • Wide band EEGの有用性 (HFO)

    秋山 倫之

    臨床神経生理   45 ( 6 )   525 - 531   2017年

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    記述言語:日本語   出版者・発行元:一般社団法人 日本臨床神経生理学会  

    &lt;p&gt;高周波振動 (HFO) は, γ帯域を超える80 Hz以上の脳波活動である。HFOの記録には, サンプリング周波数2 kHz以上, アンチエイリアシングフィルタ600 Hz以上が推奨される。HFOは, 臨床用途の電極を用いて記録できる。HFOの検出には, 低域遮断フィルタを用い, 感度を上げ, タイムスケールを引き延ばして判読する。頭蓋内脳波での発作間欠時HFOは, 発作開始領域やてんかん原性領域の局在を示唆する。頭蓋内脳波での発作開始時HFOもてんかん外科の手術成績改善に有用な可能性がある。小児てんかん性脳症では, 頭皮上脳波で発作間欠時HFOが多数出現しており, 認知機能障害への関与が推測されている。てんかん原性に関連する病的HFOを認知に関連する生理的HFOから区別する手がかりとして, てんかん性棘波をともなうか否か, 徐波成分とのカップリング様式の相違, レム睡眠における出現頻度の変化の相違などが報告されている。&lt;/p&gt;

    DOI: 10.11422/jscn.45.525

    CiNii Article

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  • てんかん教育入門コース(第2部) 脳波(小児)

    秋山 倫之

    てんかん研究   34 ( 2 )   378 - 378   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 多彩な先天異常を認めたβ-ウレイドプロピオナーゼ欠損症の一例

    柴田 敬, 秋山 倫之, 岡 牧郎, 吉永 治美, 久原 とみ子, 中島 葉子, 加藤 武馬, 前田 康博, 影山 操, 小林 勝弘

    日本先天代謝異常学会雑誌   32   201 - 201   2016年9月

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    記述言語:日本語   出版者・発行元:日本先天代謝異常学会  

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  • 新生児・乳児期発症てんかんにおける髄液中ピリドキサールリン酸測定の意義

    秋山 倫之, 柴田 敬, 吉永 治美, 小林 勝弘

    日本先天代謝異常学会雑誌   32   205 - 205   2016年9月

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    記述言語:日本語   出版者・発行元:日本先天代謝異常学会  

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  • 脳波におけるCSWSのDZP静注による改善程度と治療予後の検討

    秋山 麻里, 岡 牧郎, 秋山 倫之, 土屋 弘樹, 西本 静香, 森 篤志, 吉永 治美, 小林 勝弘

    てんかん研究   34 ( 2 )   492 - 492   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 脳波のサイエンスとアート 脳波はツールか、研究トピックか? 臨床家の立場より、正常亜型の現状・これから、用語の標準化にむけて

    秋山 倫之

    てんかん研究   34 ( 2 )   313 - 314   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • てんかん外科と包括医療 小児科の立場から

    秋山 倫之

    てんかん研究   34 ( 2 )   345 - 345   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • コハク酸セミアルデヒド脱水素酵素欠損症の1男児例

    柴田 敬, 小林 勝弘, 秋山 倫之, 岡 牧郎, 小坂 仁, 久原 とみ子, 黒澤 健司, 吉永 治美

    日本小児科学会雑誌   120 ( 7 )   1130 - 1130   2016年7月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • 【臨床神経生理で何がわかる?[2]脳波・誘発電位・眼球運動】脳波 脳波のHFO(高周波振動)

    秋山 倫之

    Clinical Neuroscience   34 ( 7 )   783 - 786   2016年7月

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    記述言語:日本語   出版者・発行元:(株)中外医学社  

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  • 神経代謝疾患の診断体制の確立に向けて

    秋山 倫之

    脳と発達   48 ( Suppl. )   S145 - S145   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • Hereditary chin tremblingの小児例

    秋山 倫之, 柴田 敬, 花岡 義行, 吉永 治美, 小林 勝弘

    脳と発達   48 ( Suppl. )   S267 - S267   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 皮質障害を伴う白質変性と末梢神経障害を来たしたFOLR1遺伝子変異による中枢性葉酸欠乏症の1例

    小林 悠, 小松原 孝夫, 眞柄 慎一, 岡崎 健一, 遠山 潤, 秋山 倫之, 才津 浩智, 松本 直通

    脳と発達   48 ( Suppl. )   S346 - S346   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • てんかん患者における長期的ビタミンB6療法は末梢神経に有害な影響を与えるか?

    井上 拓志, 柴田 敬, 遠藤 文香, 岡 牧郎, 秋山 倫之, 小林 勝弘, 吉永 治美

    脳と発達   48 ( Suppl. )   S362 - S362   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 小児けいれん重積治療ガイドライン けいれん重積状態に対する評価

    秋山 倫之, 前垣 義弘

    脳と発達   48 ( Suppl. )   S127 - S127   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 結節性硬化症のフォローアップ中にLAMが見過ごされた2例

    吉永 治美, 秋山 麻里, 遠藤 文香, 秋山 倫之, 小林 勝弘

    日本小児科学会雑誌   120 ( 2 )   387 - 387   2016年2月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • 難治性West症候群での新規抗てんかん薬治療効果 TPM & LEV

    高橋 幸利, 山口 解冬, 伊藤 智城, 九鬼 一郎, 臼井 大介, 木村 暢佑, 保立 麻美子, 池上 真理子, 大谷 早苗, 向田 壮一, 那須 裕郷, 山崎 悦子, 秋山 倫之, 高山 留美子, 最上 友紀子, 大谷 英之, 池田 浩子, 久保田 裕子, 重松 秀夫, 今井 克美, 井上 有史

    てんかん研究   33 ( 3 )   702 - 703   2016年1月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 【てんかん性wide-band EEGの記録と解析のコンセンサスへ:DC電位(緩電位)と高周波振動(HFO)】高周波振動(HFO)の実際の記録・解析

    秋山 倫之

    臨床神経生理学   43 ( 6 )   499 - 503   2015年12月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

    高周波振動(high-frequency oscillations:HFO)は、γ帯域を超える80Hz以上の脳波活動である。てんかん性HFOはてんかん原性領域の代理マーカーとして注目されており、てんかん外科の成績向上に貢献が期待されている。しかし、その記録法や判読法は施設によって差異が大きいのが現状である。HFOの記録にはサンプリング周波数2kHz以上、アンチエイリアシングフィルタ600Hz以上が推奨される。頭蓋内電極の接触面積は0.2〜5mm2が望ましい。HFOの適切な表示には、日本光電製ビューワの場合、モニタの水平ピクセル数1,920以上、高域遮断フィルタオフ、時定数0.001-0.003秒(低域遮断フィルタとして53-160Hz)、感度1〜5μV/mm、タイムスケール0.5〜1秒/ページが推奨される。コンピュータを用いたHFOのスペクトル解析と自動検出についても触れることにする。(著者抄録)

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  • 小児髄液中モノアミン類の測定系の作成

    秋山 倫之, 小林 勝弘, 井上 拓志, 吉永 治美

    脳と発達   47 ( 6 )   457 - 458   2015年11月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • コハク酸セミアルデヒド脱水素酵素欠損症の1男児例

    柴田 敬, 小林 勝弘, 秋山 倫之, 岡 牧郎, 小坂 仁, 久原 とみ子, 黒澤 健司, 吉永 治美

    日本先天代謝異常学会雑誌   31   150 - 150   2015年10月

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    記述言語:日本語   出版者・発行元:日本先天代謝異常学会  

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  • てんかん患者において長期的ビタミンB6療法が末梢神経に及ぼす影響

    井上 拓志, 柴田 敬, 遠藤 文香, 岡 牧郎, 秋山 倫之, 小林 勝弘, 吉永 治美

    てんかん研究   33 ( 2 )   622 - 622   2015年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 【てんかん】ピンポイント小児医療 てんかんの治療 小児てんかんの外科的治療の適応

    秋山 倫之

    小児内科   47 ( 9 )   1510 - 1512   2015年9月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

    <Key Points>(1)てんかん外科は最終手段ではなく、より早期に適切な時期を見極めて行うべきものである。(2)抗てんかん薬2〜3剤で発作が抑制できない場合、診断の再確認、基礎疾患の検索、てんかん外科を含む非薬物療法の適応判断のため精査を行う。(3)焦点発作と考えられ、起始部位に一貫性がある場合、焦点切除術の可能性を検討するため精査を進める。(4)焦点切除術の適応でなければ、脳梁離断術や迷走神経刺激療法、ケトン食療法の適応を検討する。(5)これらの非薬物療法の適応でない場合、最終手段として薬物療法を続ける。(著者抄録)

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  • 頭痛とてんかん・うつの脳循環代謝 頭痛学会・てんかん学会とのjoint 乳幼児重症てんかんの診断における脳循環・代謝検査の有用性 岡山大学病院てんかんセンターの半球離断術の症例を中心として

    小林 勝弘, 上利 崇, 佐々田 晋, 秋山 倫之, 岡 牧郎, 遠藤 文香, 吉永 治美, 伊達 勲

    脳循環代謝   26 ( 2 )   163 - 168   2015年8月

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    記述言語:日本語   出版者・発行元:日本脳循環代謝学会  

    乳幼児期に発症する重症てんかんの多くは,激しいてんかん性脳活動のために認知・行動発達の遅滞・障碍を来すてんかん性脳症となる.脳形成異常はその主要な原因であり,これに伴うてんかんは難治のため脳機能に可塑性がある乳児期の間の外科治療が推奨されている.乳幼児のMRIはコントラストが乏しく判読が難しいため,PETとSPECTとくにSPECTで発作時のデータから発作間欠時のデータを差し引いてMRIに重ね合わせるSISCOM(Subtraction Ictal SPECT CO-registered to MRI)が発作焦点の同定において有用である.岡山大学病院てんかんセンターで乳幼児期に半球離断術を行った重症てんかんの8症例(初回手術時年齢:生後2ヵ月〜2歳,平均9.9ヵ月)の中,MRI所見の不明瞭な2例ではSISCOMが病変同定のために有効であり,PETも効果を発揮した.これにより乳幼児のてんかん外科治療における脳循環・代謝に関わる機能神経画像の有用性が実証された.(著者抄録)

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  • 長時間脳波の判読、発作間欠期と発作時脳波について

    大坪 宏, 飯田 幸冶, 秋山 倫之, 馬場 史郎, 佐藤 洋輔, 加藤 量広, 越智 文子

    てんかん研究   33 ( 1 )   126 - 135   2015年6月

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    記述言語:日本語   出版者・発行元:一般社団法人 日本てんかん学会  

    長時間ビデオ脳波には、頭皮上はもちろんのこと、頭蓋内脳波においてはさらに膨大な情報量が含まれています。この論文では、てんかん外科の対象となる症例の脳波判読に、是非参考にしていただきたいキーポイントを紹介します。発作間欠期における;1)皮質形成異常にみられる心電図のようにリズミックな棘波、2)Generalized paroxysmal fast activity(GPFA)の側方性、3)REM睡眠時の発作間欠期脳波、発作時に関連した;4)側頭葉てんかんの心電図変化は側方性のヒント、5)筋電図も側方性の重要なヒント、6)皮質形成異常の発作直前に起きている頭蓋内脳波変化(棘波内高周波と除波のパワーバランスの崩壊)、の6つです。これらのポイントを抑えることで、てんかん病態の把握、特に外科適応評価がより確実になると考えています。

    DOI: 10.3805/jjes.33.126

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  • 日本人小児髄液中5-HIAA、HVA、遊離GABAの基準値作成の試み

    秋山 倫之, 小林 勝弘, 秋山 麻里, 岡 牧郎, 遠藤 文香, 吉永 治美

    日本小児科学会雑誌   119 ( 2 )   444 - 444   2015年2月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • 小児の髄液中vitamin B6、ピリドキサールリン酸の基準値確立の試み

    秋山 倫之, 小林 勝弘, 遠藤 文香, 岡 牧郎, 吉永 治美

    脳と発達   47 ( 1 )   60 - 60   2015年1月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 高周波振動 (HFO) の実際の記録・解析

    秋山 倫之

    臨床神経生理   43 ( 6 )   499 - 503   2015年

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    記述言語:日本語   出版者・発行元:一般社団法人 日本臨床神経生理学会  

    &lt;p&gt;高周波振動 (high-frequency oscillations: HFO) は, &amp;gamma;帯域を超える80 Hz以上の脳波活動である。てんかん性HFOはてんかん原性領域の代理マーカーとして注目されており, てんかん外科の成績向上に貢献が期待されている。しかし, その記録法や判読法は施設によって差異が大きいのが現状である。HFOの記録にはサンプリング周波数2 kHz以上, アンチエイリアシングフィルタ600 Hz以上が推奨される。頭蓋内電極の接触面積は0.2~5 mm&lt;sup&gt;2&lt;/sup&gt;が望ましい。HFOの適切な表示には, 日本光電製ビューワの場合, モニタの水平ピクセル数1,920以上, 高域遮断フィルタオフ, 時定数0.001&amp;ndash;0.003秒 (低域遮断フィルタとして53&amp;ndash;160 Hz), 感度1~5 &amp;mu;V/mm, タイムスケール0.5~1秒/ページが推奨される。コンピュータを用いたHFOのスペクトル解析と自動検出についても触れることにする。&lt;/p&gt;

    DOI: 10.11422/jscn.43.499

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  • 乳幼児重症てんかんの診断における脳循環・代謝検査の有用性―岡山大学病院てんかんセンターの半球離断術の症例を中心として―

    小林 勝弘, 上利 崇, 佐々田 晋, 秋山 倫之, 岡 牧郎, 遠藤 文香, 吉永 治美, 伊達 勲

    脳循環代謝   26 ( 2 )   163 - 168   2015年

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    記述言語:日本語   出版者・発行元:日本脳循環代謝学会  

    要旨 乳幼児期に発症する重症てんかんの多くは,激しいてんかん性脳活動のために認知・行動発達の遅滞・障碍を来すてんかん性脳症となる.脳形成異常はその主要な原因であり,これに伴うてんかんは難治のため脳機能に可塑性がある乳児期の間の外科治療が推奨されている.乳幼児のMRI はコントラストが乏しく判読が難しいため,PET とSPECT とくにSPECT で発作時のデータから発作間欠時のデータを差し引いてMRI に重ね合わせるSISCOM(Subtraction Ictal SPECT CO-registered to MRI)が発作焦点の同定において有用である.岡山大学病院てんかんセンターで乳幼児期に半球離断術を行った重症てんかんの8 症例 (初回手術時年齢:生後2 カ月~2 歳,平均9.9 カ月)の中,MRI 所見の不明瞭な2 例ではSISCOM が病変同定のために有効であり,PETも効果を発揮した.これにより乳幼児のてんかん外科治療における脳循環・代謝に関わる機能神経画像の有用性が実証された.

    DOI: 10.16977/cbfm.26.2_163

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  • 頭蓋内脳波における高周波解析を基に切除計画を立てた難治性てんかんの1手術例

    近藤 聡彦, 吉永 治美, 伊達 勲, 秋山 倫之, 上利 崇, 岡 牧郎, 小林 由典, 林 裕美子, 柴田 敬, 新治 有径, 小林 勝弘

    脳外誌   24 ( 1 )   32 - 39   2015年

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    記述言語:日本語   出版者・発行元:日本脳神経外科コングレス  

    &amp;emsp;難治性新皮質てんかんの外科治療の際, 発作焦点の同定のために頭蓋内脳波記録は有用であるが, 脳波の解析法や結果の解釈の相違により切除範囲や手術成績に影響が生じ得る. 今回, われわれは難治性の後頭葉てんかん患者に対して, 慢性頭蓋内電極を留置し, 高周波律動 (HFO) の解析を行った. 独自のプログラムを用いてHFOの脳表カラーマップを作成し, マップ上のHFOの出現部位を参考に切除範囲を決定して, 焦点切除術を行った. 術後1年経過した現在, 発作は完全に抑制されている. 脳表カラーマップは発作時HFOの動的変化の視覚化に有用であり, この結果に基づいてHFO検出部位を切除範囲に含むことが良好な術後成績に寄与するものと考えられた.

    DOI: 10.7887/jcns.24.32

    Scopus

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  • DCシフトとHFOのskills workshop 高周波振動(HFO)の実際の記録・解析

    秋山 倫之

    臨床神経生理学   42 ( 5 )   268 - 268   2014年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

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  • 小児良性部分てんかんの脳波における高周波振動と棘波の分布に関する検討

    柴田 敬, 小林 勝弘, 井上 拓志, 秋山 倫之, 吉永 治美

    臨床神経生理学   42 ( 5 )   285 - 285   2014年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

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  • 小児てんかん外科領域における臨床神経生理学 小児てんかん外科における高周波律動と尖度解析

    秋山 倫之

    臨床神経生理学   42 ( 5 )   244 - 244   2014年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

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  • Dravet症候群におけるStiripentolの初期および長期効果の検討

    秋山 麻里, 小林 勝弘, 岡 牧郎, 秋山 倫之, 吉永 治美

    てんかん研究   32 ( 2 )   391 - 391   2014年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • ピリドキシンおよびピリドキサール依存症 (特集 新生児期に特徴的なけいれん性疾患)

    秋山 倫之

    小児科   55 ( 8 )   1155 - 1160   2014年7月

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    記述言語:日本語   出版者・発行元:金原出版  

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  • 小児科領域に特化した臨床実習前トレーニングの試み

    大野 直幹, 岡田 あゆみ, 赤木 朋子, 八代 将登, 秋山 倫之, 遠藤 文香, 山根 正修, 森島 恒雄

    医学教育   45 ( Suppl. )   124 - 124   2014年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • 緊急少数電極脳波の振幅・周波数統合トレンド表示は脳波非習熟者における判読精度を向上させるか?

    小林 勝弘, 柚木 宏介, 禅正 和真, 秋山 倫之, 吉永 治美

    脳と発達   46 ( Suppl. )   S312 - S312   2014年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • Naチャネル異常による筋疾患の臨床多様性

    柴田 敬, 吉永 治美, 秋山 倫之, 岡 牧郎, 小林 勝弘, 村上 暢子, 迫田 俊一

    脳と発達   46 ( Suppl. )   S244 - S244   2014年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • バルプロ酸にトピラマートを追加した場合、血中アンモニア濃度は上昇するか?

    秋山 麻里, 秋山 倫之, 小林 勝弘, 吉永 治美

    てんかん研究   31 ( 2 )   432 - 432   2013年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • THE GENERATIVE PROCESS OF EPILEPTIC HIGH-FREQUENCY OSCILLATIONS AS SHOWN THROUGH NEURONAL NETWORK SIMULATION OF THE RAT DENTATE GYRUS

    K. Kobayashi, T. Akiyama, Ohmori, I, T. Inoue, H. Yoshinaga

    EPILEPSIA   54   46 - 46   2013年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

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  • 小児の積極的早期てんかん外科治療 : 小児神経科医は何を見て考えて行動すべきか?

    秋山 倫之

    脳と発達   45 ( 3 )   211 - 215   2013年5月

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    記述言語:日本語   出版者・発行元:一般社団法人 日本小児神経学会  

    &amp;emsp;難治てんかん患者を診たら, てんかん診断の再確認と基礎疾患の確認のための精査を行う. 同時に外科治療の可能性も考える. 焦点切除術の適応例では, 発作抑制効果は外科治療の方が高い. 精査が困難な場合, 専門施設への紹介を考慮されたい. まず発作時ビデオ脳波とMRIを行う. MRIは, 微細な病変の見落としを最小限にするため, てんかんに特化した撮影条件を神経放射線科医との協力で作成して用いる. 必要に応じてPET, SPECT, 脳磁図等を行い, 手術適応を決定する. 術後の発達の最終転帰は術前の発達レベルに規定される. 発達レベルが落ちてしまう前に外科治療の可能性を見つけ出すことが, 小児神経科医の重要な役割である.

    DOI: 10.11251/ojjscn.45.211

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  • Colored Density Spectral Array(CDSA)を用いたCSWSをもつてんかんの評価(第2報) 正常脳波との比較

    伊藤 智城, 最上 友紀子, 高山 留美子, 大谷 英之, 秋山 倫之, 池田 浩子, 今井 克美, 白石 秀明, 重松 秀夫, 高橋 幸利, 井上 有史

    てんかん研究   30 ( 2 )   417 - 417   2012年9月

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  • Occipital Lobe Epilepsy in Children: Pre-operative Evaluation with Magnetoencephalography and Surgical Outcomes

    George M. Ibrahim, Gregory Albert, Aria Fallah, Hiroshi Otsubo, Ayako Ochi, Tomoyuki Akiyama, Elizabeth Donner, Shelly Weiss, O. Carter Snead, James Drake, James Rutka

    JOURNAL OF NEUROSURGERY   117 ( 2 )   A399 - A399   2012年8月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER ASSOC NEUROLOGICAL SURGEONS  

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  • 眼窩前頭皮質・前頭前皮質背外側部の限局性皮質形成異常を認める前頭葉てんかんの1例

    福山 哲広, 小川 理世, 伊藤 智城, 臼井 大介, 九鬼 一郎, 秋山 麻里, 最上 友紀子, 高山 留美子, 大谷 英之, 秋山 倫之, 池田 浩子, 今井 克美, 重松 秀夫, 高橋 幸利

    脳と発達   44 ( 4 )   346 - 346   2012年7月

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  • 脳炎脳症後てんかんの慢性期におけるステロイドパルス治療の経験

    山口 解冬, 高橋 幸利, 伊藤 智城, 高橋 宏佳, 福山 哲広, 最上 友紀子, 高山 留美子, 大谷 英之, 秋山 倫之, 池田 浩子, 今井 克美, 重松 秀夫, 井上 有史

    脳と発達   44 ( Suppl. )   S260 - S260   2012年5月

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  • Colored Density Spectral Array(CDSA)を用いたCSWSを持つてんかんの評価

    伊藤 智城, 最上 友紀子, 高山 留美子, 池田 浩子, 大谷 英之, 秋山 倫之, 今井 克美, 重松 秀夫, 高橋 幸利, 井上 有史

    脳と発達   44 ( Suppl. )   S347 - S347   2012年5月

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  • 対側優位の脳波所見を有する片側広汎性萎縮性病変の難治てんかんに対し大脳半球離断術が著効した2例

    高山 留美子, 今井 克美, 須藤 章, 白石 秀明, 南 弘一, 伊藤 智城, 九鬼 一郎, 秋山 麻里, 最上 友紀子, 秋山 倫之, 池田 浩子, 重松 秀夫, 馬場 好一, 高橋 幸利, 井上 有史

    脳と発達   44 ( Suppl. )   S269 - S269   2012年5月

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  • 二相性けいれんと遅発性拡散低下を伴う急性脳症後のてんかん(第1報) 発作型・脳波に関する検討

    那須 裕郷, 高橋 幸利, 伊藤 智城, 木村 暢佑, 九鬼 一郎, 福山 哲広, 山口 解冬, 高山 留美子, 最上 友紀子, 大谷 英之, 秋山 倫之, 池田 浩子, 今井 克美, 重松 秀夫, 井上 有史

    脳と発達   44 ( Suppl. )   S229 - S229   2012年5月

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  • Dravet症候群の経過中に発症した脳症の検討(第2報) 脳症時と非脳症時の遷延発作の比較

    高山 留美子, 高橋 幸利, 那須 裕郷, 木村 暢佑, 山口 解冬, 福山 哲広, 最上 友紀子, 大谷 英之, 秋山 倫之, 池田 浩子, 今井 克美, 重松 秀夫, 廣瀬 伸一, 山川 和弘, 井上 有史

    脳と発達   44 ( Suppl. )   S233 - S233   2012年5月

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  • 小児非ヘルペス性辺縁系脳炎後てんかん4例の臨床的特徴についての検討

    福山 哲広, 山崎 悦子, 九鬼 一郎, 高橋 宏佳, 高山 留美子, 大谷 英之, 秋山 倫之, 池田 浩子, 今井 克美, 重松 秀夫, 久保田 英幹, 高橋 幸利, 井上 有史

    脳と発達   44 ( Suppl. )   S272 - S272   2012年5月

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  • モリブデン補酵素欠損症の1例

    高山 留美子, 秋山 倫之, 木村 暢佑, 那須 裕郷, 最上 友紀子, 今井 克美, 高橋 幸利, 井上 有史, 玉置 一智, 市田 公美

    日本小児科学会雑誌   116 ( 2 )   415 - 415   2012年2月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • 最近提唱されている新しいてんかん病型.

    秋山倫之, 小林勝弘

    小児内科   44 ( 9 )   1461 - 1465   2012年

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  • 発作間欠期頭蓋内脳波の尖度の意義、およびてんかん外科後の発作予後に対する尖度の影響

    秋山 倫之, 越智 文子, 秋山 麻里, 大坪 宏

    臨床神経生理学   39 ( 5 )   403 - 403   2011年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

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  • てんかん性スパズムおよび発作間欠期てんかん性発射に伴う頭蓋内脳波上の徐波の解析 高周波との分布の検討(Distributions of ictal and interictal slow waves in patients with epileptic spasms: Comparison with high frequency oscillations using intracranial EEG)

    秋山 麻里, 秋山 倫之, 越智 文子, 大坪 宏

    てんかん研究   29 ( 2 )   334 - 334   2011年9月

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    記述言語:英語   出版者・発行元:(一社)日本てんかん学会  

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  • てんかん外科後の発作予後に対する、発作間欠期頭蓋内脳波の尖度分布と切除領域との関連性の影響

    秋山 倫之, 秋山 麻里, 越智 文子, 大坪 宏

    脳と発達   43 ( Suppl. )   S194 - S194   2011年5月

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  • Autoimmune Limbic Encephalitis in a Paediatric Patient

    Blathnaid Mc Coy, Tomoyuki Akiyama, Elysa Widjaja, Cristina Go

    NEUROLOGY   74 ( 9 )   A441 - A441   2010年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Electroclinical characterization and classification of symptomatic epilepsies with very early onset by multiple correspondence analysis

    Akiyama T, Kobayashi K, Ohtsuka Y

    Epilepsy Res   91 ( 2 )   232 - 239   2010年

  • LOCALIZATION OF EPILEPTIC FOCI IN CHILDREN WITH INTRACTABLE EPILEPSY SECONDARY TO MULTIPLE CORTICAL TUBERS USING SYNTHETIC APERTURE MAGNETOMETRY KURTOSIS

    Ichiro Sugiyama, K. Imai, A. Ochi, C. Go, T. Akiyama, O. C. Snead, E. Widjaja, S. H. Chuang, H. Otsubo

    EPILEPSIA   50   177 - 177   2009年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

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  • CONCORDANCE BETWEEN DISTRIBUTION OF INTERICTAL FAST RIPPLES AND RESECTION AREA MAY CONTRIBUTE TO SEIZURE FREEDOM FOR EPILEPSY SURGERY

    Tomoyuki Akiyama, C. Go, A. Ochi, I. Sugiyama, E. J. Donner, S. K. Weiss, O. C. Snead, J. T. Rutka, J. Drake, I. Elliott, H. Otsubo

    EPILEPSIA   50   448 - 449   2009年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

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  • 治療とケア--症例から考える 動作開始時に異常姿勢およびけいれん発作を示す14歳男児

    秋山 倫之

    Epilepsy   3 ( 1 )   42 - 44   2009年5月

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    記述言語:日本語   出版者・発行元:メディカルレビュー社  

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  • P1-16 ジャクソン発作における高周波律動の伝播様式 : 発作時ビデオ脳波と高周波律動の動画による検討(脳波・脳磁図1,一般演題(ポスター),第42回日本てんかん学会)

    秋山 倫之, 越智 文子, 杉山 一郎, 藤本 礼尚, 大坪 宏

    てんかん研究   26 ( 2 )   2008年9月

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    記述言語:日本語   出版者・発行元:日本てんかん学会  

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  • てんかん診療最前線 てんかん高周波振動の意義

    山崎 まどか, 越智 文子, 秋山 倫之

    Epilepsy   2 ( 1 )   51 - 58   2008年5月

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    記述言語:日本語   出版者・発行元:メディカルレビュー社  

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  • 食事によって誘発されるシリーズ形成性spasmsを認めた小児例

    井上 拓志, 秋山 倫之, 小林 勝弘

    臨床脳波   50 ( 4 )   246 - 250   2008年4月

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    記述言語:日本語   出版者・発行元:永井書店  

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  • EPILEPTOGENIC FAST OSCILLATIONS IN PATIENTS WITH HEMIMEGALENCEPHALY BEFORE AND AFTER FUNCTIONAL HEMISPHERECTOMY

    Madoka Yamazaki, Zulma S. Tovar-Spinoza, Derrick Chan, Cristina Go, Katsumi Imai, Ayako Ochi, B. Chu, Tomoyuki Akiyama, J. Rutka, J. M. Drake, O. C. Snead, H. Otsubo

    EPILEPSIA   49   27 - 27   2008年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

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  • PROPAGATION OF ICTAL HIGH-FREQUENCY OSCILLATIONS DURING FOCAL NEOCORTICAL SEIZURES: TOPOGRAPHIC MAP MOVIE OF HIGH-FREQUENCY OSCILLATIONS INTEGRATED WITH INTRACRANIAL EEG AND SEIZURE SEMIOLOGY

    Tomoyuki Akiyama, A. Ochi, Derrick Chan, S. K. Weiss, O. C. Snead, I. Elliott, J. T. Rutka, J. M. Drake, H. Otsubo

    EPILEPSIA   49   9 - 9   2008年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

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  • 小児神経科医としてのてんかん外科へのアプローチ

    秋山 倫之

    脳と発達 = OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF CHILD NEUROLOGY   39 ( 3 )   236 - 237   2007年5月

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    記述言語:日本語   出版者・発行元:脳と発達  

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  • 乳児早期,おもに新生児期発症のてんかん (特集/てんかん診療ABC)

    秋山 倫之, 大塚 頌子

    小児科診療   70 ( 1 )   77 - 83   2007年1月

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    記述言語:日本語   出版者・発行元:診断と治療社  

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  • 小児のてんかんによる摂食・嚥下障害の要因について(第2報) : てんかん分類による分析

    石田 瞭, 有岡 享子, 秋山 倫之, 森田 幸介, 森 貴幸, 北 ふみ, 江草 正彦, 大塚 頌子

    障害者歯科 = JOURNAL OF THE JAPANESE SOIETY FOR DISABILITY AND ORAL HEALTH   27 ( 3 )   2006年9月

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    記述言語:日本語  

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  • O1-06 Epileptic spasmsの発作時脳波におけるgamma律動の周波数構造に関する研究(脳波2,一般演題(口演),第40回 日本てんかん学会)

    井上 拓志, 小林 勝弘, 菊本 健一, 岡 牧郎, 秋山 倫之, 大塚 頌子

    てんかん研究   24 ( 3 )   2006年8月

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    記述言語:日本語   出版者・発行元:日本てんかん学会  

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  • N-2 てんかん原性焦点におけるてんかん発作時の高周波解析(Ictogenesis and Epileptogenesis,神経科学セッション,第40回 日本てんかん学会)

    大坪 宏, 秋山 倫之, 今井 克美, 越智 文子

    てんかん研究   24 ( 3 )   2006年8月

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  • Topographic movie of ictal high-frequency oscillations on the brain surface using subdural EEG in neocortical epilepsy

    Tomoyuki Akiyama

    NEUROPSYCHOBIOLOGY   54 ( 1 )   29 - 29   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:KARGER  

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  • Patterns of ictal high-frequency oscillation correlating to clinical seizure expressions in children with intractable localization related epilepsy

    Ayako Ochi, Hiroshi Otsubo, Katsumi Imai, Ayataka Fujimoto, Tomoyuki Akiyama, Elizabeth J. Donner, Irene Elliott, Rohit Sharma, James T. Rutka, O. Carter Snead

    EPILEPSIA   47   44 - 45   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • Epileptic spasms in older children: MEG spike cluster and ictal high frequency oscillations identify the ictal onset zone

    Rajesh RamachandranNair, Ayako Ochi, Erick Sell, Tomoyuki Akiyama, James T. Rutka, S. Holowka, S. H. Chuang, Hiroshi Otsubo

    EPILEPSIA   47   57 - 57   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • Topographic movie of ictal high-frequency oscillations on the brain surface using subdural EEG in neocortical epilepsy

    H. Otsubo, T. Akiyama, A. Ochi, E. Donner, J. Rutka, C. Snead

    EPILEPSIA   47   114 - 114   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • 興味深い家族内発症を認めたムンプス脳炎の1例

    和田 智顕, 高橋 秀明, 石田 敏章, 長尾 隆志, 鷲尾 佳奈, 山下 信子, 萬木 章, 森島 恒雄, 伊藤 美奈子, 秋山 倫之

    日本小児科学会雑誌   109 ( 4 )   574 - 575   2005年4月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • High frequency oscillations in epileptic spasms of focal cortical origin confirmed by subdural electroencephalogram

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    EPILEPSIA   46   221 - 221   2005年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • The prevalence of secondary epileptogenic foci in patients with localization related epilepsy secondary to cortical dysplasias

    EZ Galicia, H Otsubo, IS Mohamed, R Sakuta, T Akiyama, A Ochi, JT Rutka, SH Chuang, S Manohar, SK Weiss, OC Snead

    EPILEPSIA   46   149 - 149   2005年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • Clinical and electrical characteristics of epilepsies with very early onset.

    T Akiyama, K Abiru, K Nakano, K Kobayashi, Y Ohtsuka

    EPILEPSIA   46   22 - 23   2005年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • Incidence and distribution of epileptic syndromes in children

    E Oka, Y Ohtsuka, H Yoshinaga, K Kobayashi, T Ogino, T Akiyama

    EPILEPSIA   46   387 - 387   2005年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • Characterizing ictal high frequency oscillations in children with intractable neocortical epilepsy

    A Ochi, H Otsubo, R Iwata, T Funaki, T Akiyama, R Sharma, SK Weiss, E Donner, Elliott, I, JT Rutka, OC Snead

    EPILEPSIA   46   319 - 320   2005年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • Dynamic changes of high-frequency oscillations on brain surface topographic maps using multiple band frequency analysis for localization of epileptogenic zones

    T Akiyama, H Otsubo, A Ochi, R RamachandranNair, R Elliot, E Donner, SK Weiss, JT Rutka, OC Snead

    EPILEPSIA   46   312 - 313   2005年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • Etiologic analysis of epilepsy in children.

    E Oka, H Yoshinaga, K Kobayashi, T Akiyama, H Ohta, T Nakabori

    EPILEPSIA   46   87 - 87   2005年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING INC  

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  • 症例 眼球運動発作を示した難治性後頭葉てんかん

    渡邊 嘉章, 吉永 治美, 秋山 倫之

    臨床脳波 = Clinical electroencephalography : 脳波・筋電図と臨床神経生理   45 ( 5 )   339 - 344   2003年5月

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    記述言語:日本語   出版者・発行元:永井書店  

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  • 乳児良性ミオクロニーてんかん (特集 小児のミオクロニー発作の診断の進め方と治療)

    秋山 倫之, 岡 鍈次

    小児科   43 ( 10 )   1404 - 1408   2002年9月

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    記述言語:日本語   出版者・発行元:金原出版  

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  • 乳児期早期におけるてんかん発射の出現に関する検討

    遠藤 文香, 吉永 治美, 荻野 竜也, 秋山 倫之, 太田 穂高, 岡 〓次

    日本てんかん学会プログラム・予稿集   ( 36 )   2002年

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    記述言語:日本語   出版者・発行元:日本てんかん学会  

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  • ギラン・バレー症候群におけるCMAP振幅低下の意義について (ギラン・バレー症候群)

    秋山 倫之, 吉永 治美, 岡 鍈次

    臨床脳波 = Clinical electroencephalography : 脳波・筋電図と臨床神経生理   43 ( 9 )   547 - 551   2001年9月

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    記述言語:日本語   出版者・発行元:永井書店  

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  • Electroencephalographic changes and their regional differences during pediatric cardiovascular surgery with hypothermia

    Akiyama T, Kobayashi K, Nakahori T, Yoshinaga H, Ogino T, Ohtsuka Y, Takeuchi M, Morita K, Sano S, Oka E

    Brain Dev   2001年

  • B-13 複雑部分発作の発作時脳波の有用性と限界

    吉永 治美, 大守 伊織, 浅野 孝, 秋山 倫之, 岡 〓次

    日本てんかん学会プログラム・予稿集   ( 34 )   2000年

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    記述言語:日本語   出版者・発行元:日本てんかん学会  

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  • 体外循環と低体温法を用いた小児開心手術中の脳波変化に関する研究

    秋山 倫之

    岡山醫學會雜誌   111 ( 3 )   71 - 83   1999年8月

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    記述言語:日本語   出版者・発行元:岡山医学会  

    An electroencephalographic (EEG) study eith a multi-channel digital record was carried out to investigate EEG changes and their spatial characteristics accompanying hypothermia and cerebral ischemia during open-heart surgery in children. Subjects consisited of 10 children, ranging from 1 year 6 months to 4 years 6 months old, who underwent open-heart surgery with extracorporeal circulation and hypothermia. The EEG changes were evaluated visually and analyzed using a computer. (1) A discontinuous EEG pattern was notted during cooling in addition to commonly observed finding inculuding a decrease in fast waves, slowing and amplitude reduction, and was considered caused by rapid and transient suppression of cerebral function. (2) Power spectral and topographical analyses revealed a prominent decrease in fast waves and a relative increase in slow waves during cooling. Durong cerebral ischemia, in contrast, an actual increase in slow waves and decrease in fast waves were observed. (3) We noted the characteristics of bilateral synchronous rhythmic high-voltage slow waves among various types of transient EEG abnor-malities. (4) EEG changes induced by hypothermia differed by brain region. (5) EEG changes induced by hypothermia were influenced not only by body temperature itself but also by the rate of change in body temperature.

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  • Isolation of epileptiform discharges from unaveraged EEG by independent component analysis

    Kobayashi K, James CJ, Nakahori T, Akiyama T, Gotman J

    Clin Neurophysiol   1999年

  • Dipole analysis in a case with tumor-related epilepsy

    Yoshinaga H, Nakahori T, Hattori J, Akiyama T, Oka E, Tomit S, Aoi M, Ohmoto T, Miyamoto K

    Brain & Development   1999年

  • C-37 小児期の非痙攣性てんかん重積状態に関する研究

    大塚 頌子, 太田 穂高, 秋山 倫之, 榎 日出夫, 吉永 治美, 岡 〓次

    日本てんかん学会プログラム・予稿集   ( 33 )   1999年

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    記述言語:日本語   出版者・発行元:日本てんかん学会  

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  • A-19 ポケットモンスター事件のけいれん性疾患患者に対する影響

    村上 暢子, 榎 日出夫, 水口 栄太, 秋山 倫之, 服部 旬里, 岡 〓次

    日本てんかん学会プログラム・予稿集   ( 32 )   1998年

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    記述言語:日本語   出版者・発行元:日本てんかん学会  

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  • E-11 Mesial Temporal Lobe Epilepsy (MTLE) の画像診断に関する研究

    大野 繁, 大塚 頌子, 村上 暢子, 秋山 倫之, 岡 〓次, 田中 朗雄, 清 哲朗, 平木 祥夫

    日本てんかん学会プログラム・予稿集   ( 30 )   1996年

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    記述言語:日本語   出版者・発行元:日本てんかん学会  

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受賞

  • 研究褒賞

    2014年3月   財団法人日本てんかん治療研究振興財団  

    秋山 倫之

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  • JUHN AND MARY WADA奨励賞

    2012年10月   日本てんかん学会  

    秋山 倫之

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共同研究・競争的資金等の研究

  • てんかんのバイオマーカー探索 - 網羅的代謝プロファイリングの活用

    2017年04月 - 2020年03月

    公益財団法人てんかん治療研究振興財団  平成29年度研究助成 

    秋山 倫之

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    担当区分:研究代表者  資金種別:競争的資金

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  • 限局性皮質異形成II型のてんかん発作に対するシロリムスの有効性と安全性に関する無対照非盲検医師主導治験

    2017年04月

    国立研究開発法人日本医療研究開発機構  臨床研究・治験推進研究事業 

    加藤 光広

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    資金種別:競争的資金

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  • 脳クレアチン欠乏症候群を 中心とした治療可能な知的障害症候群の臨床研究

    2016年04月 - 2018年03月

    厚生労働省  厚生労働科学研究費難治性疾患政策研究事業 

    和田 敬仁

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    資金種別:競争的資金

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  • 網羅的代謝物質分析による先天性代謝異常症の効率的診断

    2016年04月 - 2017年03月

    公益財団法人岡山医学振興会  平成28年度公募助成 

    秋山 倫之

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    担当区分:研究代表者  資金種別:競争的資金

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  • 代謝物質分析による けいれん重積型脳症の発症予測因子・重症化因子の検討

    2015年04月 - 2020年03月

    日本学術振興会  科学研究費基盤研究(C) 

    秋山 倫之

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    担当区分:研究代表者  資金種別:競争的資金

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担当授業科目

  • 小児医科学(発達神経病態学)I(演習・実習) (2021年度) 特別  - その他

  • 小児医科学(発達神経病態学)I(講義・演習) (2021年度) 特別  - その他

  • 小児医科学(発達神経病態学)II(演習・実習) (2021年度) 特別  - その他

  • 小児医科学(発達神経病態学)II(講義・演習) (2021年度) 特別  - その他

  • 小児医科学(発達神経病態学)I(演習・実習) (2020年度) 特別  - その他

  • 小児医科学(発達神経病態学)I(講義・演習) (2020年度) 特別  - その他

  • 小児医科学(発達神経病態学)II(演習・実習) (2020年度) 特別  - その他

  • 小児医科学(発達神経病態学)II(講義・演習) (2020年度) 特別  - その他

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