Faculty Profiles - SHIGEYASU Kunitoshi

Papers - SHIGEYASU Kunitoshi

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A Case of Gastric Cancer Developed after Pylorus-Preserving Gastrectomy in a Patient with Lynch Syndrome Reviewed

金谷信彦, 田中屋宏爾, 重安邦俊, 國友知義, 山崎理恵, 青木秀樹, 竹内仁司

癌と化学療法 41 ( 12 ) 2264 - 5 2014

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Cancer and Chemotherapy Publishers Inc.

Lynch syndrome is an inherited autosomal dominant disorder caused by germ-line mutation of mismatch repair genes, in which a malignant tumor develops at a young age in the colon, endometrium, stomach, or other tissues. A 54-year-old patient with gastric cancer received pylorus-preserving gastrectomy, and a genetic examination confirmed a pathological variation of the MLH1 gene. Five years after surgery, an upper gastrointestinal endoscopy revealed a residual 0 -IIa+IIc gastric tumor approximately 2 cm in size extending from the anastomotic site to the lesser curvature side of the stomach. The remaining stomach was completely removed. The final diagnosis was T1b (SM) N1M0, StageIB gastric cancer. Microsatellite instability was positive, and we attributed the cancer to Lynch syndrome. In Lynch syndrome, the risk of multicentric gastric cancer is higher than normal, and for the initial therapy, preventive total gastrectomy should be considered as an option.

Advanced hepatocellular carcinoma with lymph node metastases showing epithelial to mesenchymal transition effectively treated with systemic chemotherapy: Report of a case. Reviewed International journal

Hiroshi Sadamori, Takahito Yagi, Kunitoshi Shigeyasu, Yuzo Umeda, Masahiro Sugihara, Naosuke Yokomichi, Toshiaki Ohara, Naoshi Nishida, Takeshi Nagasaka, Ajay Goel, Toshiyoshi Fujiwara

Hepatology research : the official journal of the Japan Society of Hepatology 43 ( 12 ) 1368 - 73 2013.12

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

We present a case in which combination chemotherapy was used to successfully treat hepatocellular carcinoma (HCC) with rapid progression of lymph node (LN) metastases after liver resection. In addition, epithelial to mesenchymal transition (EMT) markers were examined immunohistochemically. A 43-year-old man who had been diagnosed with HCC showed an enlarged LN near the hepatic artery proper. After extended left lobectomy with lymphadenectomy in the hepatoduodenal ligament, he experienced rapid progression of metastases to the para-aortic and mediastinal LN. Partial remission was achieved after induction and maintenance of combination chemotherapy using etoposide, carboplatin, epirubicin and 5-fluorouracil. As a consequence of this treatment, the patient survived 10 months. Immunohistochemical studies demonstrated that HCC cells in the metastatic LN showed low expression of E-cadherin and high expression of N-cadherin and vimentin, indicating EMT. Combination chemotherapy may prove effective for patients with HCC accompanied by LN metastases that show features of EMT.

DOI： 10.1111/hepr.12080

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MGMT Methylation As a Novel Biomarker for the Identification of Stage III Colorectal Cancers At High-Risk of Disease Recurrence Following Curative Surgery Reviewed

Yoshiko Mori, Takeshi Nagasaka, Hiroshi Tazawa, Yuzo Umeda, Tatsuya Morikawa, Nobuhito Kubota, Kazuhiro Yoshida, Yuko Takehara, Naosuke Yokomichi, Kiyoto Takehara, Kunitoshi Shigeyasu, Akihiro Nyuya, Rikiya Shiwaku, Manabu Suno, Naoshi Nishida, Toshiyoshi Fujiwara, Ajay Goel

GASTROENTEROLOGY 144 ( 5 ) S85 - S85 2013.5

Accumulation of Epigenetic Alteration Could Predict Malignant Formation in Intraductal Papillary Mucinous Neoplasm (IPMN) Reviewed

Kazuhiro Yoshida, Takeshi Nagasaka, Yuzo Umeda, Naosuke Yokomichi, Yoshiko Mori, Nobuhito Kubota, Tatsuya Morikawa, Yuko Takehara, Kiyoto Takehara, Kunitoshi Shigeyasu, Akihiro Nyuya, Rikiya Shiwaku, Manabu Suno, Naoshi Nishida, Toshiyoshi Fujiwara, Ajay Goel

GASTROENTEROLOGY 144 ( 5 ) S98 - S98 2013.5

Genetic and Epigenetic Alterations in the Netrin-1 Receptors, UNC5c and DCC, Constitutes a Previously Unrecognized Pathway in Gastric Cancer Progression Reviewed

Nobuhito Kubota, Takeshi Nagasaka, Keisuke Toda, Yoshiko Mori, Tatsuya Morikawa, Yuzo Umeda, Naosuke Yokomichi, Kazuhiro Yoshida, Yuko Takehara, Kiyoto Takehara, Akihiro Nyuya, Rikiya Shiwaku, Kunitoshi Shigeyasu, Manabu Suno, Naoshi Nishida, Toshiyoshi Fujiwara, Ajay Goel

GASTROENTEROLOGY 144 ( 5 ) S527 - S527 2013.5

Cytokeratin 19 Staining Is a Novel, Predictive Biomarker for Extra-Hepatic Metastasis in Hepatocellular Carcinoma Reviewed

Naosuke Yokomichi, Takeshi Nagasaka, Naoshi Nishida, Yuzo Umeda, Yoshiko Mori, Tatsuya Morikawa, Nobuhito Kubota, Kazuhiro Yoshida, Yuko Takehara, Kiyoto Takehara, Kunitoshi Shigeyasu, Akihiro Nyuya, Rikiya Shiwaku, Manabu Suno, Toshiyoshi Fujiwara, Ajay Goel

GASTROENTEROLOGY 144 ( 5 ) S719 - S720 2013.5

Fecal DNA Methylation Assay for the Identification of a Multiple Gastrointestinal Cancers Including Pancreatic Caner Reviewed

Tatsuya Morikawa, Takeshi Nagasaka, Kazuhiro Yoshida, Yoshiko Mori, Nobuhito Kubota, Yuko Takehara, Naosuke Yokomichi, Naoshi Nishida, Kiyoto Takehara, Kunitoshi Shigeyasu, Akihiro Nyuya, Rikiya Shiwaku, Manabu Suno, Toshiyoshi Fujiwara, Ajay Goel

GASTROENTEROLOGY 144 ( 5 ) S601 - S602 2013.5

Multicenter phase II study of S-1 and docetaxel combination chemotherapy for advanced or recurrent gastric cancer patients with peritoneal dissemination. Reviewed International journal

Kunitoshi Shigeyasu, Shunsuke Kagawa, Futoshi Uno, Masahiko Nishizaki, Hiroyuki Kishimoto, Akira Gochi, Toshikazu Kimura, Takaomi Takahata, Yasuyuki Nonaka, Motoki Ninomiya, Toshiyoshi Fujiwara

Cancer chemotherapy and pharmacology 71 ( 4 ) 937 - 43 2013.4

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

PURPOSE: Peritoneal dissemination is the most frequent and life-threatening mode of metastasis and recurrence in patients with gastric cancer. A multicenter phase II study was designed to evaluate the efficacy and tolerability of S-1 and docetaxel combination chemotherapy regimen for the treatment of advanced or recurrent gastric cancer patients with peritoneal dissemination. METHODS: Nineteen patients with histologically confirmed unresectable or recurrent gastric cancer with peritoneal dissemination were enrolled. Oral S-1 at 80 mg/m(2)/day was administered twice daily for 2 weeks, followed by 1 drug-free week. Docetaxel infusion at 40 mg/m(2) was performed on day 1, simultaneous with S-1 administration. The primary endpoints were overall survival (OS) and time to progression (TTP). The secondary endpoints were the response rates and safety status. RESULTS: Patients received a median of 4 cycles of the S-1 and docetaxel regimen (range 1-43). The disease control rate was 73.7 % (14/19). Median overall survival was 459 days (15.3 months), while median time to progression was 212 days (7.1 months). Neutropenia was the most common type of toxicity (n = 7, 36.8 %). CONCLUSIONS: Combination chemotherapy with S-1 and docetaxel is a tolerable and effective treatment for advanced or recurrent gastric cancer patients with peritoneal dissemination.

DOI： 10.1007/s00280-013-2086-0

A highly sensitive detection system of genetic alterations in circulating tumor cells using a telomerase-specific replication-competent adenovirus

Kunitoshi Shigeyasu, Yuuri Hashimoto, Tatsuya Morikawa, Yoshiko Mori, Dong-Sheng Sun, Shunsuke Kagawa, Futoshi Uno, Hiroshi Tazawa, Takeshi Nagasaka, Satoru Kyo, Hiroyuki Mizuguchi, Yasuo Urata, Toshiyoshi Fujiwara

CANCER RESEARCH 72 2012.4

Expansion of CpG methylation in the SFRP2 promoter region during colorectal tumorigenesis. Reviewed

Masanori Takeda, Takeshi Nagasaka, Sun Dong-Sheng, Hiroyuki Nishie, Tetsuhiro Oka, Eiji Yamada, Yoshiko Mori, Kunitoshi Shigeyasu, Tatsuya Morikawa, Satoshi Mizobuchi, Toshiyoshi Fujiwara

Acta medica Okayama 65 ( 3 ) 169 - 77 2011.6

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

Secreted frizzled-related protein 2, (SFRP2) is a Wnt inhibitor whose promoter CpGs were recently found to be methylated at high frequency in colorectal cancers (CRCs). We hypothesized that the pattern of SFRP2 methylation may differ throughout the promoter during progressive tumorigenesis. Using combined bisulfite restriction analysis (COBRA), two methylation-sensitive regions (Regions A and B) of the SFRP2 promoter were investigated in 569 specimens of colorectal tissue:222 CRCs, 103 adenomatous polyps (APs), 208 normal colonic mucosa from CRC patients (N-Cs), and 36 normal colonic mucosa from subjects with no evidence of colorectal neoplasia at colonoscopy (N-Ns). Extensive (including both Regions A and B) and partial (either Region A or B) SFRP2 methylation levels were found in 61.7% and 24.8% of CRCs, 8.7% and 37.9% of APs, 3.9% and 39.9% of N-Cs, and 0% and 30.6% of N-Ns, respectively. Extensive methylation of the SFRP2 promoter was present primarily in CRCs, while partial methylation was common in APs. Whereas APs with the KRAS mutant showed no correlation to any pattern of SFRP2 methylation, extensive methylation of the SFRP2 promoter was significantly associated with KRAS mutant CRCs (p＜.0001), suggesting that genetic alteration in the RAS-RAF pathway might precede the spread of CpG methylation through the SFRP2 promoter, which is observed in over 60% of advanced colorectal tumors.

DOI： 10.18926/AMO/46628

Web of Science

PubMed

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当院における肝癌治療の変遷

竹内仁司, 重安邦俊, 大原利章, 荒田尚, 村田宏, 金澤卓, 中川仁志, 田中屋宏爾, 金川泰一朗, 安井義政, 大田剛由, 詫間義隆, 牧野泰裕

山口県医学会誌 ( 41 ) 170 - 170 2007.3

医師個人の技術評価におけるPOSSUM scoring systemの有用性

竹内仁司, 安井義政, 金川泰一朗, 田中屋宏爾, 中川仁志, 金澤卓, 村田宏, 荒田尚, 大原利章, 重安邦俊, 愛洲尚哉

日本外科学会雑誌 108 ( 臨増2 ) 715 - 715 2007.3

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