研究者詳細 - 小山　敏広

論文 - 小山　敏広

分割表示 98 件中 81 - 98 件目／全件表示 >>

Chronic hyperinsulinemia induces hypertension resulted from abnormal innervation of perivascular nerves in rat mesenteric resistance arteries 査読国際誌

Yoshito Zamami, Shingo Takatori, Nana Yabumae, Miho Hosoda, Toshihiro Koyama, Xin Jin, Narumi Hobara, Kenji Sasaki, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 112 76P - 76P 2010年

Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds 査読国際誌

Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Narumi Hobara, Toshihiro Koyama, Pengyuan Sun, Simin Li, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 111 ( 4 ) 372 - 380 2009年12月

Proton Acts as a Neurotransmitter for Nicotine-Induced Adrenergic and Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in the Rat Mesenteric Artery 査読国際誌

Hiromu Kawasaki, Shinji Eguchi, Satoko Miyashita, Shu Chan, Kazuhiro Hirai, Narumi Hobara, Ayako Yokomizo, Hidetoshi Fujiwara, Yoshito Zamami, Toshihiro Koyama, Xin Jin, Yoshihisa Kitamura

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 330 ( 3 ) 745 - 755 2009年9月

腎血管性高血圧における血管周囲神経の機能変化査読

小山敏広, 畑中由香子, 合田光寛, 座間味義人, 芳原成美, 川崎博己

薬学雑誌 129 ( 2 ) 185 - 189 2009年2月

Functional Alteration of Nervous System in Renovascular Hypertension 査読

Toshihiro Koyama, Yukako Hatanaka, Mitsuhiro Goda, Yoshito Zamami, Narumi Hobara, Hiromu Kawasaki

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 129 ( 2 ) 185 - 189 2009年2月

Young Pharmacological Researchers Develop the Way to Drug Discovery Based on Interpretation of Diseases and Medicinal Assessment: The Way to Create New Drugs by Fields Interchange Foreword 査読

Toshihiro Koyama, Sokichi Honda

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 129 ( 2 ) 183 - 183 2009年2月

Changes in neuronal regulation of vascular tone and its pathophysiological role in diabetic state 査読

Yoshito Zamami, Shingo Takatori, Yukiko Iwatani, Xin Jin, Toshihiro Koyama, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 109 25P - 25P 2009年

Royal jelly ameliorates insulin resistance in fructose-drinking rats. 査読

Yoshito Zamami, Shingo Takatori, Mitsuhiro Goda, Toshihiro Koyama, Yukiko Iwatani, Xin Jin, Shima Takai-Doi, Hiromu Kawasaki

Biological & pharmaceutical bulletin 31 ( 11 ) 2103 - 7 2008年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension.

DOI： 10.1248/bpb.31.2103

PubMed

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A ketolide antibiotic, telithromycin, inhibits vascular adrenergic neurotransmission in the rat mesenteric vascular bed 査読

Y. Hatanaka, Y. Zamami, T. Koyama, N. Hobara, X. Jin, Y. Kitamura, H. Kawasaki

British Journal of Pharmacology 155 ( 6 ) 826 - 836 2008年11月

A ketolide antibiotic, telithromycin, inhibits vascular adrenergic neurotransmission in the rat mesenteric vascular bed 査読

Y. Hatanaka, Y. Zamami, T. Koyama, N. Hobara, X. Jin, Y. Kitamura, H. Kawasaki

BRITISH JOURNAL OF PHARMACOLOGY 155 ( 6 ) 826 - 836 2008年11月

Characterization of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric resistance arteries 査読

Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Toshihiro Koyama, Pengyuan Sun, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 108 ( 1 ) 95 - 103 2008年9月

若手薬理研究者が展開する病態解明と薬効評価による創薬へのアプローチ領域を超えた交流から広がる創薬への道腎血管性高血圧ラット腸間膜動脈における血管周囲一酸化窒素含有神経の機能変化

小山敏広, 畑中由香子, 合田光寛, 芳原成美, 高山房子, 川崎博己

日本薬学会年会要旨集 128年会 ( 1 ) 249 - 249 2008年3月

腎性高血圧ラット腸間膜動脈における血管周囲一酸化窒素含有神経機能変化

小山敏広, 庄司知世, 畑中由香子, 合田光寛, 芳原成美, 高山房子, 川崎博己

日本薬理学雑誌 131 ( 3 ) 25p - 25p 2008年3月

[Effect of propolis on insulin resistance in fructose-drinking rats]. 査読

Yoshito Zamami, Shingo Takatori, Toshihiro Koyama, Mitsuhiro Goda, Yukiko Iwatani, Shima Doi, Hiromu Kawasaki

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 127 ( 12 ) 2065 - 73 2007年12月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）

Propolis, a honeybee product, contains a variety of biologically active substances. The present study was designed to investigate the effects of propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), body weight, and systolic blood pressure but not blood glucose levels, when compared with control rats. Brazilian propolis extract (100 and 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose and total cholesterol levels, and tended to decrease systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, propolis treatment resulted in a significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS; 8 Hz) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, propolis treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that propolis could be an effective functional food to prevent the development of insulin resistance.

DOI： 10.1248/yakushi.127.2065

PubMed

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高血圧モデルラットの腸間膜動脈における一酸化窒素含有神経の血管緊張度調節における機能変化

小山敏広, 庄司知世, 畑中由香子, 合田光寛, 芳原成美, 高山房子, 川崎博己

日本薬理学雑誌 129 ( 2 ) 32P - 32P 2007年2月