Faculty Profiles - Takagi Kosei

Papers - Takagi Kosei

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Liver transplantation; Liver transplantation for HCC, when and how? Complicated portal vein reconstruction, technical consideration 肝細胞癌切除後再発に対する肝移植タイミングの見極め(Liver transplantation: Liver transplantation for HCC, when and how? Complicated portal vein reconstruction, technical consideration Prediction of salvage liver transplantation for hepatocellular carcinoma recurrence after hepatic resection)

楳田祐三, 八木孝仁, 篠浦先, 吉田龍一, 信岡大輔, 渡辺信之, 杭瀬崇, 藤智和, 須井健太, 高木弘誠, 藤原俊義

日本肝胆膵外科学会・学術集会プログラム・抄録集 28回 360 - 360 2016.6

肝細胞癌切除術後長期成績に対する術前Controlling Nutritional Status(CONUT)Scoreの意義

高木弘誠, 八木孝仁, 藤智和, 杭瀬崇, 渡辺信之, 信岡大輔, 吉田龍一, 楳田祐三, 篠浦先, 藤原俊義

外科と代謝・栄養 50 ( 3 ) 144 - 144 2016.6

非機能性pNETにおける、肝転移症例の検討と外科的治療戦略

杭瀬崇, 楳田裕三, 高木弘誠, 藤智和, 須井健太, 渡辺信之, 信岡大輔, 吉田龍一, 篠浦先, 八木孝仁

日本肝胆膵外科学会・学術集会プログラム・抄録集 28回 481 - 481 2016.6

右側肝円索・門脈分枝走行異常を伴った進行胆嚢癌切除の経験

吉田龍一, 高木弘誠, 須井健太, 藤智和, 杭瀬崇, 渡辺信之, 信岡大輔, 楳田佑三, 篠浦先, 八木孝仁, 藤原俊義

日本肝胆膵外科学会・学術集会プログラム・抄録集 28回 429 - 429 2016.6

各科手術におけるエネルギーデバイス使用の現状高機能電気メス付CUSAによる肝切除

楳田祐三, 篠浦先, 吉田龍一, 信岡大輔, 渡辺信之, 杭瀬崇, 藤智和, 高木弘誠, 八木孝仁, 藤原俊義

日本外科系連合学会誌 41 ( 3 ) 402 - 402 2016.5

白血病治療中の骨髄抑制期に発症した急性虫垂炎の1例

吉川公見子, 杭瀬崇, 木村裕司, 高木弘誠, 藤智和, 須井健太, 渡辺信之, 信岡大輔, 吉田龍一, 楳田祐三, 篠浦先, 猪俣知子, 乗金精一郎, 田中健大, 八木孝仁, 藤原俊義

岡山医学会雑誌 128 ( 1 ) 78 - 78 2016.4

A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan. Reviewed International journal

Yuki Inagaki, Yukio Oshiro, Tomohiro Tanaka, Tomoharu Yoshizumi, Hideaki Okajima, Kohei Ishiyama, Chikashi Nakanishi, Masaaki Hidaka, Hiroshi Wada, Taizo Hibi, Kosei Takagi, Masaki Honda, Kaori Kuramitsu, Hideaki Tanaka, Taiji Tohyama, Toshihiko Ikegami, Satoru Imura, Tsuyoshi Shimamura, Yoshimi Nakayama, Taizen Urahashi, Kazumasa Yamagishi, Hiroshi Ohnishi, Shigeo Nagashima, Masaharu Takahashi, Ken Shirabe, Norihiro Kokudo, Hiroaki Okamoto, Nobuhiro Ohkohchi

EBioMedicine 2 ( 11 ) 1607 - 12 2015.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Recently, chronic hepatitis E has been increasingly reported in organ transplant recipients in European countries. In Japan, the prevalence of hepatitis E virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the prevalence of chronic HEV infection in Japanese liver transplant recipients. METHODS: A total of 1893 liver transplant recipients in 17 university hospitals in Japan were examined for the presence of immunoglobulin G (IgG), IgM and IgA classes of anti-HEV antibodies, and HEV RNA in serum. FINDINGS: The prevalence of anti-HEV IgG, IgM and IgA class antibodies was 2.9% (54/1893), 0.05% (1/1893) and 0% (0/1893), respectively. Of 1651 patients tested for HEV RNA, two patients (0.12%) were found to be positive and developed chronic infection after liver transplantation. In both cases, HEV RNA was also detected in one of the blood products transfused at the perioperative period. Analysis of the HEV genomes revealed that the HEV isolates obtained from the recipients and the transfused blood products were identical in both cases, indicating transfusion-transmitted HEV infection. INTERPRETATION: The prevalence of HEV antibodies in liver transplant recipients was 2.9%, which is low compared with the healthy population in Japan and with organ transplant recipients in European countries; however, the present study found, for the first time, two Japanese patients with chronic HEV infection that was acquired via blood transfusion during or after liver transplantation.

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結腸右半切除を伴う拡大膵頭十二指腸切除術後の再建の工夫

佐藤博紀, 信岡大輔, 安井和也, 高木弘誠, 杭瀬崇, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦先, 八木孝仁, 藤原俊義

日本消化器外科学会雑誌 48 ( Suppl.2 ) 203 - 203 2015.10

腹腔鏡下肝切除の適応拡大に向けたcadaver trainingの実際

信岡大輔, 八木孝仁, 近藤喜太, 佐藤博紀, 森廣俊昭, 高木弘誠, 安井和也, 杭瀬崇, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦先, 大塚愛二, 藤原俊義

日本消化器外科学会雑誌 48 ( Suppl.2 ) 206 - 206 2015.10

高齢化社会に向けたこれからの胃癌治療戦略治療すべきか経過観察かサルコペニアが高齢胃癌患者の予後に及ぼす影響

桑田和也, 高木弘誠, 菊地覚次, 黒田新士, 吉田龍一, 西崎正彦, 香川俊輔, 藤原俊義

日本胃癌学会総会記事 87回 175 - 175 2015.3

Correlation of Computed Tomography Imaging Features and Pathological Features of 41 Patients with Pancreatic Neuroendocrine Tumors Reviewed

Masashi Utsumi, Yuzo Umeda, Kosei Takagi, Kuise Takashi, Daisuke Nobuoka, Ryuichi Yoshida, Susumu Shinoura, Hiroshi Sadamori, Takahito Yagi, Toshiyoshi Fujiwara

HEPATO-GASTROENTEROLOGY 62 ( 138 ) 441 - 446 2015.3

Language：English Publishing type：Research paper (scientific journal) Publisher：H G E UPDATE MEDICAL PUBLISHING S A

Background:/Aims: Pancreatic neuroendocrine tumors (PNET) are relatively rare. Here, we present clinical and pathological characteristics of PNETs to show a relationship between computed tomography (CT) imaging and the 2010 World Health Organization (WHO) classification. Methodology: We retrospectively reviewed the records of 41 PNET patients who were treated between 2002 and 2012. All tumors were classified as neuroendocrine tumor (NET) grade 1 (121), NET grade 2 (G2), or neuroendocrine carcinoma (NEC) grade 3 (G3) on the basis of the 2010 WHO classification system. Results: Twenty-five tumors were classified as G1, 11 as G2, and five as G3. Mean sizes of the G1, G2 and G3 tumors were 1.84 +/- 0.54, 4.90 +/- 0.84, and 5.62 +/- 1.18 cm, respectively, (P < 0.01). A PNET is typically hypervascular and exhibits contrast enhancement on enhanced CT. Higher percentage of G1 tumors demonstrated typical imaging and showed a significantly greater distinct mass compared with G2 and G3 tumors. Conclusions: Although PNET has many imaging features that appear on CT, G2 and G3 tumors often show atypical imaging features, particularly with large sizes and/or ill-defined features, when compared with G1 tumors. If a PNET has atypical imaging features, possibility of malignancy should be considered.

DOI： 10.5754/hge14388

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Risk Factors of Morbidity and Predictors of Long-term Survival after Hepatopancreatoduodenectomy for Biliary Cancer Reviewed

Masashi Utsumi, Hiroshi Sadamori, Susumu Shinoura, Yuzo Umeda, Ryuichi Yoshida, Daisuke Nobuoka, Kosei Takagi, Toshiyoshi Fujiwara, Takahito Yagi

HEPATO-GASTROENTEROLOGY 61 ( 136 ) 2167 - 2172 2014.11

Language：English Publishing type：Research paper (scientific journal) Publisher：H G E UPDATE MEDICAL PUBLISHING S A

Background/Aims: Hepatopancreatoduodenectomy (HPD) is performed to achieve radical resection of malignant biliary tumors. We reviewed clinical outcomes to evaluate the utility of HPD in terms of morbidity and mortality. Methodology: A retrospective analysis was conducted on 17 patients underwent HPD between August 1991 and May 2013; 9 bile duct cancel; 5 advanced gallbladder and 3pancreatic tumor with liver metastasis. Results: The morbidity and mortality rates were 88.3% and 0%, respectively. Univariate analysis showed that a body mass index of >= 22 and preoperative total bilirubin level >= 0.8 mg/dl were significantly associated with severe complications. One, 3- and 5-year survival rate were 73.3%, 60.0% and 30.0%. In 14 patients with biliary carcinoma, univariate analysis showed that a histological grade of G1 was significantly associated with survival. Patients without pancreatic invasion or portal vein invasion tended to survive longer than patients with these types of invasion, although the difference was not significant. Conclusions: HPD can be performed with no mortality and provides a survival benefit for some patients with biliary carcinoma undergoing curative resection. In patients with grade G1 biliary carcinoma without pancreatic or portal vein invasion in particular, this aggressive surgery might offer a chance of long-term survival.

DOI： 10.5754/hge14701

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肝胆膵外科手術の修練方法遺体を用いた肝胆膵外科手術教育

信岡大輔, 八木孝仁, 近藤喜太, 森廣俊昭, 高木弘誠, 藤智和, 渡邉祐介, 杭瀬崇, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦先, 日置勝義, 藤原俊義

日本臨床外科学会雑誌 75 ( 増刊 ) 333 - 333 2014.10

Surgical education using a multi-viewpoint and multi-layer three-dimensional atlas of surgical anatomy (with video). Reviewed

Daisuke Nobuoka, Tomokazu Fuji, Kazuhiro Yoshida, Kosei Takagi, Takashi Kuise, Masashi Utsumi, Ryuichi Yoshida, Yuzo Umeda, Susumu Shinoura, Yoshimasa Takeda, Aiji Ohtsuka

Journal of hepato-biliary-pancreatic sciences 21 ( 8 ) 556 - 61 2014.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Trainee surgeons must have a good understanding of surgical anatomy. Especially in the hepatobiliary-pancreatic field, beginning surgeons often find it difficult to recognize the three-dimensional structure of the target organ and its complex anatomical correlation with surrounding organs. Conventional anatomy textbooks are not written with the aim of teaching these three-dimensional structures and complex correlations. We developed a novel teaching atlas of surgical anatomy using a multi-viewpoint and multi-layer three-dimensional camera system. METHODS: Layer-by-layer dissection of the upper abdominal organs of a cadaver was performed by expert surgeons. A stereoscopic camera system was used to capture a series of anatomical views. The images were remodeled in a multi-viewpoint and multi-layer manner. RESULTS: Images of each dissection layer could be viewed serially from the appropriate angle, which was tilted up to 90° along the anteroposterior axis. The clinical anatomy specific to the surgical procedure could thus be learned using this atlas system. CONCLUSIONS: Rotatable three-dimensional panoramic views of local dissection of the upper abdominal organs of a cadaver were developed for educational purposes. Trainee surgeons could use these anatomical images instead of conventional anatomical atlases to learn how to perform surgical procedures such as pancreaticoduodenectomy and major hepatectomy.

DOI： 10.1002/jhbp.108

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乳児急性リンパ性白血病臍帯血移植後に発症した肝中心静脈閉塞症に対し生体肝移植、骨髄移植を施行した1例

吉田龍一, 高木弘誠, 藤智和, 内海方嗣, 信岡大輔, 楳田祐三, 篠浦先, 貞森裕, 保田裕子, 藤原俊義, 八木孝仁

移植 49 ( 1 ) 130 - 130 2014.5

脳死ドナーの増加は肝移植成績を改善したか脳死肝移植成績当院15症例の検討

篠浦先, 八木孝仁, 貞森裕, 楳田祐三, 吉田龍一, 佐藤太祐, 信岡大輔, 内海方嗣, 藤智和, 高木弘誠, 藤原俊義

日本肝胆膵外科学会・学術集会プログラム・抄録集 25回 241 - 241 2013.6

肝腫瘍および生体肝移植ドナーにおける肝切離法の工夫

貞森裕, 八木孝仁, 篠浦先, 楳田祐三, 吉田龍一, 佐藤太祐, 信岡大輔, 内海方嗣, 藤智和, 高木弘誠, 藤原俊義

日本肝胆膵外科学会・学術集会プログラム・抄録集 25回 319 - 319 2013.6

生体肝移植の手術手技の工夫低体重児に対するS2移植+in situ reductionをもちいたsub-monosegment liver transplantation

八木孝仁, 貞森裕, 篠浦先, 楳田祐三, 吉田龍一, 佐藤太祐, 内海方嗣, 信岡大輔, 杉原正大, 藤智和, 高木弘誠, 藤原俊義

日本肝胆膵外科学会・学術集会プログラム・抄録集 25回 287 - 287 2013.6

[Two cases of CPT-11 and CDDP chemotherapy for advanced pancreatic cancer]. Reviewed

Kosei Takagi, Kazuyuki Kawamoto, Tadashi Itoh

Gan to kagaku ryoho. Cancer & chemotherapy 39 ( 5 ) 847 - 9 2012.5

Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)

We report two cases of advanced pancreatic cancer treated with CPT-11 and CDDP as third-line chemotherapy. CPT-11 was administered as an intravenous injection at a dose of 60 mg/m², and CDDP was administered at a dose of 30 mg/m2 biweekly. The patients showed no adverse events greater than grade 2 toxicity, and these adverse events were tolerated. The patients showed partial response and stable disease. These results suggested that this treatment schedule was safe and effective for progressive pancreatic cancer.

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[A case of drug-induced interstitial pneumonitis after chemotherapy with UFT and leucovorin for multiple lung metastases of rectal cancer]. Reviewed

Kosei Takagi, Kazuyuki Kawamoto, Hiroyoshi Ikeda, Tadashi Itoh

Gan to kagaku ryoho. Cancer & chemotherapy 38 ( 6 ) 1025 - 7 2011.6

Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)

The patient was a 70-year-old male who had multiple lung metastases of rectal cancer. He was administered UFT(300mg/ day)and LV(75mg/day)after Hartmann operation for rectal cancer. He complained of fever and difficulty breathing after 2 courses of these medicines, and was admitted for UFT-and LV-induced interstitial pneumonitis. Treatment with methylpredni- solone(30mg/day)improved his symptoms and revealed radical findings. He was ready for discharge on the 10th day after treatment. Interstitial pneumonitis-induced UFT and LV is rare, but can lead to severe complications, which should be diagnosed and treated by corticosteroid as soon as possible.

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Papers - Takagi Kosei