Updated on 2025/04/25

写真a

 
Sakamoto Kota
 
Organization
Scheduled update Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
External link

Degree

  • 修士(学際情報学) ( 2021.3   東京大学 )

  • 修士(学際情報学) ( 東京大学 )

Education

  • The University of Tokyo   大学院情報学環・学際情報学府  

    2019.4 - 2021.3

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  • Chuo University   理工学部   人間総合理工学科

    2015.4 - 2019.3

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Professional Memberships

 

Papers

  • Comparison of robotic versus manual needle insertion for CT-guided intervention: prospective randomized trial

    Takao Hiraki, Yusuke Matsui, Jun Sakurai, Koji Tomita, Mayu Uka, Soichiro Kajita, Noriyuki Umakoshi, Toshihiro Iguchi, Michihiro Yoshida, Kota Sakamoto, Takayuki Matsuno, Tetsushi Kamegawa

    Radiology Advances   2 ( 2 )   2025.3

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    Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    Background

    Robotic needle insertion under CT guidance has been developed, but data on comparison with manual insertion are still lacking.

    Purpose

    To compare robotic versus manual needle insertion for CT fluoroscopy-guided intervention, primarily in terms of insertion accuracy.

    Materials and Methods

    This was a prospective study between May 2020 and March 2023 at a single site. The cohort comprised 22 patients undergoing CT (Aquilion One or Aquilion CX; Canon Medical Systems) fluoroscopy-guided biopsy, who were randomly allocated to either the robotic or manual group. The robot used (Zerobot; Medicalnet Okayama) is not yet commercially available. A biopsy introducer needle was inserted by 1 of 3 physicians using a remote-control robot in the robotic group, versus by 1 of 3 different physicians by hand in the manual group. The primary endpoint was needle insertion accuracy, which was defined as the 3-dimensional Euclidean distance between a predetermined target point and the needle tip after insertion. The non-inferiority of robotic insertion to manual one was then tested. Adverse events were evaluated. Statistical comparisons were made between the 2 groups.

    Results

    Technical success and pathological findings were confirmed in all patients of the 2 groups. The mean and SD of needle insertion were 4.8 mm ± 2.6 in the robotic group and 7.0 mm ± 3.1 in the manual group (P < .001). The mean difference in accuracy between the 2 groups (robotic minus manual group) was −2.1 mm (95% CI, −4.7 to 0.4). Effective dose to physicians was zero in all cases in the robotic group, while median dose was 1.0 µSv in the manual group (P < .001). Dose length product to patients was not significantly different between the 2 groups (P = .100). No major adverse events were observed.

    Conclusion

    Robotic needle insertion was non-inferior to manual insertion in terms of accuracy, while it effectively eliminated radiation exposure to physicians.

    Trial registration number

    jRCT2062200013

    DOI: 10.1093/radadv/umaf010

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    Other Link: https://academic.oup.com/radadv/article-pdf/2/2/umaf010/62871840/umaf010.pdf

  • A randomized, open-label, clinical trial examined the effects of canagliflozin on albuminuria and eGFR decline using an individual pre-intervention eGFR slope. International journal

    Satoshi Miyamoto, Hiddo J L Heerspink, Dick de Zeeuw, Kota Sakamoto, Michihiro Yoshida, Masao Toyoda, Daisuke Suzuki, Takashi Hatanaka, Tohru Nakamura, Shinji Kamei, Satoshi Murao, Kazuyuki Hida, Shinichiro Ando, Hiroaki Akai, Yasushi Takahashi, Munehiro Kitada, Hisashi Sugano, Tomokazu Nunoue, Akihiko Nakamura, Motofumi Sasaki, Tatsuaki Nakatou, Kei Fujimoto, Daiji Kawanami, Takashi Wada, Nobuyuki Miyatake, Hiromi Kuramoto, Kenichi Shikata

    Kidney international   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    Demonstrating drug efficacy in slowing kidney disease progression requires large clinical trials when targeting participants with an early stage of chronic kidney disease (CKD). In this randomized, parallel-group, open-labeled trial (CANPIONE study), we assessed the effect of the sodium-glucose cotransporter 2 (SGLT2) inhibitor canagliflozin using the individual's change in estimated glomerular filtration rate (eGFR) slope before (pre-intervention slope) and during treatment (chronic slope).We randomly assigned (1:1) participants with type 2 diabetes, urinary albumin-to-creatinine ratio (UACR) of 50 to under 300 mg/g, and an eGFR of at least 45 ml/min/1.73m2 to receive canagliflozin or guideline-recommended treatment except for SGLT2inhibitors (control). The first and second primary outcomes were the geometric mean percentage change from baseline in UACR and the change in eGFR slope, respectively. Of 98 randomized participants, 96 received at least one study treatment. The least-squares mean change from baseline in log-transformed geometric mean UACR was significantly greater in the canagliflozin group than the control group (between group-difference, -30.8% (95% confidence interval -42.6 to -16.8). The between-group difference (canagliflozin group - control group) of change in eGFR slope (chronic - pre-intervention) was 4.4 (1.6 to 7.3) ml/min/1.73 m2 per year, which was more pronounced in participants with faster eGFR decline. In summary, canagliflozin reduced albuminuria and the participant-specific natural course of eGFR decline in participants with type 2 diabetes and microalbuminuria. Thus, the CANPIONE study suggest that the within-individual change in eGFR slope may be a novel approach to determine the kidney protective potential of new therapies in early stages of CKD.

    DOI: 10.1016/j.kint.2024.08.019

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Presentations

  • 若手統計家の職業性ストレスの職務着任後の追跡調査

    中薗孝輔, 寺島瞭平, 坂本航太, 内藤あかり, 若手統計家の集い, 会員有志

    第15回 臨床試験学会学術集会 

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    Event date: 2024.3.7

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  • 特別企画・若手企画4 若手統計家はみた!臨床試験データのその後!:総括報告書での報告について

    坂本航太

    ARO協議会第8回学術集会  2021.9 

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    Event date: 2021.9.10 - 2021.9.11

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  • 専門家連絡会企画2:STAT/DM/IT:「臨床予測モデルにおける基礎」

    坂本航太

    ARO協議会第10回学術集会  2023.8.25 

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    Language:Japanese  

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  • 若手生物統計家の育成環境のあり方に関する検討

    坂本 航太, 中塚 夕貴, 齋多 遼太郎, 日髙 優, 中薗 孝輔, 三友 優治, 伊藤 知洋, 内藤 あかり

    第14回 臨床試験学会学術集会  2023.2.9 

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    Presentation type:Poster presentation  

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  • 若手統計家の今後-キャリア形成と展望について-

    中塚 夕貴, 坂本 航太, 齋多 遼太郎, 日髙 優, 中薗 孝輔, 三友 優治, 伊藤 知洋, 内藤 あかり

    第14回 臨床試験学会学術集会  2023.2.9 

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    Presentation type:Poster presentation  

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  • 若手統計家の実態調査研究報告

    斎多遼太郎, 日高優, 坂本航太, 中園孝輔, 中塚夕貴, 三友優治

    ARO協議会第9回学術集会  2022.9.16 

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Awards

  • 優秀修士論文(専攻長賞)

    2021.3   東京大学 大学院学際情報学府 学際情報学専攻  

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