Updated on 2025/06/18

写真a

 
MARUYAMA Takayuki
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
Position
Associate Professor
External link

Degree

  • 博士（歯学） ( 2012.3   岡山大学 )

  • Ph.D. ( 2012.3   Okayama University )

Research Interests

  • 周術期口腔機能管理

  • 予防歯科学

  • 頭頸部がん

  • 歯周病

  • 動物実験

  • 臨床研究

  • 疫学研究

Research Areas

  • Life Science / Social dentistry

Education

  • Okayama University   大学院医歯薬学総合研究科   口腔保健学分野

    2007.4 - 2012.3

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  • Okayama University   歯学部   歯学科

    2001.4 - 2007.3

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Research History

  • 岡山大学学術研究院医歯薬学域   准教授

    2023.12

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  • 岡山大学学術研究院医歯薬学域   助教

    2020.4 - 2023.11

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  • Okayama University   新医療研究開発センター   Assistant Professor

    2014.1 - 2020.3

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  • Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences   Assistant Professor

    2012.4 - 2013.12

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Committee Memberships

  •   Healthcare編集委員  

    2025.4   

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    Committee type：Academic society

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  •   BMC Oral Health編集委員  

    2025.4   

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    Committee type：Academic society

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  • 日本口腔衛生学会   査読委員  

    2021.5   

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    Committee type：Academic society

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  • 岡山大学臨床研究審査委員会   副委員長  

    2020.4   

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    Committee type：Other

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  • 日本口腔衛生学会   代議員  

    2013.5   

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    Committee type：Academic society

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Papers

  • Effects of Trehalose on Halitosis: A Randomized Cross-Over Clinical Trial. International journal

    Hisataka Miyai, Takaaki Tomofuji, Hirofumi Mizuno, Manabu Morita, Momoko Nakahara, Kota Kataoka, Ichiro Sumita, Yurika Uchida, Naoki Toyama, Aya Yokoi, Reiko Yamanaka-Kohno, Noriko Takeuchi, Takayuki Maruyama, Daisuke Ekuni

    Healthcare (Basel, Switzerland)   13 ( 6 )   2025.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    Background/Objectives: Halitosis is a condition characterized by an unpleasant malodor. Intra-oral halitosis is caused by volatile sulfur compounds (VSCs) and can be associated with oral dryness. Trehalose is one of the materials used to relieve oral dryness. The aim of the present study was to investigate the effect of trehalose on halitosis. Methods: This prospective, double-blinded, placebo-controlled, cross-over study enrolled volunteers from Okayama University Hospital. The participants were randomly divided into two groups, with one group receiving trehalose (a 10% trehalose solution) and the other receiving a placebo (distilled water) in a 1:1 allocation. The primary study outcome was the subjective organoleptic test. The secondary outcomes were the concentrations of the VSCs, which were measured using a portable gas chromatography device, and the oral moisture status, which was measured using an oral moisture meter. The planned sample size was 10 participants based on the previous study. Results: The final intention-to-treat analysis was performed using the data from 9 participants. After applying 10% trehalose as an oral spray, the organoleptic score decreased in a time-dependent manner. However, no significant differences were seen between the trehalose and placebo groups. In terms of secondary outcomes, the oral moisture levels increased immediately after the trehalose spray application, and significant differences in the amount of change from the baseline were seen between the trehalose and placebo groups (p = 0.047). No significant differences were seen in any of the other variables (p > 0.05). Conclusions: We could not identify any positive effects on halitosis from a one-time 10% trehalose application as an oral spray in this prospective, double-blinded, placebo-controlled, cross-over study. However, the trehalose application immediately improved the oral moisture levels and was useful for treating oral dryness.

    DOI： 10.3390/healthcare13060619

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  • Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial. International journal

    Takayuki Maruyama, Eiji Takayama, Shinichi Tokuno, Manabu Morita, Daisuke Ekuni

    Healthcare (Basel, Switzerland)   13 ( 5 )   2025.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    Background/Objectives: Initiation and progression of periodontal disease include oxidative stress. Systemic application of antioxidants may provide clinical benefits against periodontal disease including gingivitis. Recently, a jelly containing a high concentration of hydrogen (40 ppm) was developed. We hypothesized that oral intake of this hydrogen-rich jelly may be safe and effective on gingivitis. This clinical trial was designed to investigate the safety and efficacy of oral intake of hydrogen-rich jelly against gingival inflammation. Methods: Participants with gingivitis were instructed to orally ingest 30 g of hydrogen-rich jelly (experimental group) or placebo jelly (control group) three times a day for 14 consecutive days. The primary outcome of this trial was the percentage of bleeding on probing (BOP) sites. Secondary outcomes were oral parameters, serum reactive oxygen metabolites, antioxidant capacity, oxidative index, concentrations of cytokine (interleukin [IL]-1β, IL-6, IL-10, IL-17, and tumor necrosis factor-alpha) in gingival crevicular fluid, and adverse events. For all parameters, Mann-Whitney U test was used for comparison between experimental and control groups. Analysis of covariance, controlling for baseline periodontal inflamed surface area, was performed to evaluate the association between the effect of the hydrogen-rich jelly and gingival inflammation. Results: In the experiment and control groups, the percentage of sites with BOP and PISA significantly decreased at the end of the experiment compared to the baseline. However, no significant differences were found between groups (p > 0.05). Conclusions: Administration of hydrogen-rich jelly for 14 days decreased gingival inflammation. However, no significant differences were identified compared to the control group.

    DOI： 10.3390/healthcare13050577

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  • Relationship among cancer treatment, quality of life, and oral function in head and neck cancer survivors: A cross-sectional study. Reviewed International journal

    Aya Yokoi, Takayuki Maruyama, Reiko Yamanaka, Noriko Takeuchi, Manabu Morita, Daisuke Ekuni

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer   32 ( 12 )   809 - 809   2024.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Treatment for head and neck cancer (HNC), such as surgery and chemoradiotherapy, can reduce oral function and affect quality of life (QoL). However, whether HNC treatment affects QoL via the decline of oral function remains unclear. This study aimed to investigate the relationship among cancer treatment, QoL, and actual oral function in HNC survivors. METHODS: A total of 100 HNC survivors who had completed definitive treatment for HNC at least 6 months prior to enrollment were enrolled in this cross-sectional study. QoL was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 summary score. Oral diadochokinesis (ODK), tongue pressure, moisture level on the mucosal surface, and mouth opening were measured. Information on age, sex, tumor site, tumor stage, history of HNC treatment, height, body weight, and lifestyle were collected from medical records. Structural equation modeling (SEM) was conducted to analyze the indirect/direct associations among HNC treatment, QoL, and oral function. RESULTS: In total, 100 HNC survivors (58 males and 42 females; age range, 30-81 years, median, 67 years) were analyzed. Overall, 63 patients (63.0%) were diagnosed as oral cancer, 66 (66.0%) developed advanced cancer (stage 3/4), and 58 (58.0%) underwent reconstruction surgery in 100 HNC survivors. The SEM results supported the hypothesized structural model (root mean square error of approximation = 0.044, comparative fit index = 0.990, Tucker-Lewis index = 0.986). Surgery with neck dissection and reconstruction for advanced cancer had indirect effects on lower QoL via ODK and mouth opening. CONCLUSION: HNC treatment is indirectly associated with QoL via oral function in HNC survivors.

    DOI： 10.1007/s00520-024-09015-y

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  • Perioperative gum-chewing training prevents a decrease in tongue pressure after esophagectomy in thoracic esophageal cancer patients: a nonrandomized trial Reviewed

    Reiko Yamanaka-Kohno, Yasuhiro Shirakawa, Aya Yokoi, Naoaki Maeda, Shunsuke Tanabe, Kazuhiro Noma, Kazuyoshi Shimizu, Toshiharu Mituhashi, Yoshihide Nakamura, Souto Nanba, Yurika Uchida, Takayuki Maruyama, Manabu Morita, Daisuke Ekuni

    Scientific Reports   14 ( 1 )   2024.10

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Tongue pressure (TP) decreases significantly after esophagectomy in esophageal cancer patients (ECPs). Meanwhile, 2 weeks of gum-chewing training (GCT) significantly increased TP in healthy university students. We examined whether perioperative GCT would decrease the proportion of patients exhibiting a decline in TP at 2 weeks postoperatively, and prevent postoperative complications, in thoracic ECPs (TECPs). This was a single-center interventional study, and nonrandomized study with a historical control group (HCG). TECPs who underwent first-stage radical esophagectomy were recruited. Thirty-two patients of 40 in the gum-chewing group (GCG) were completed perioperative GCT in 3 times daily. Propensity score matching was performed with covariates related to TP including preoperative age, sex, body mass index, and the repetitive saliva swallowing test result, and yielded a matched cohort of 25 case pairs. Eleven GCG patients [44.0%] exhibited significantly lower TP at 2 weeks postoperatively than before esophagectomy was significantly fewer than that of 19 patients [76.0%] in the HCG. The median number of fever days (> 38 °C) in the 2 weeks after esophagectomy in the GCG was significantly fewer than those in the HCG. Perioperative GCT may prevent postoperative TP decline and postoperative dysphagia-related complications after esophagectomy.

    DOI： 10.1038/s41598-024-74090-4

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    Other Link： https://www.nature.com/articles/s41598-024-74090-4

  • 口腔内のPorphyromonas gingivalis菌数と血清中抗ジンジパイン抗体価の関連性

    中村 彪雅, 下津 尭子, 安居 良太, 大廣 義幸, 安田 多賀子, 丸山 貴之, 畑中 加珠, 江國 大輔, 高柴 正悟

    臨床化学   53 ( Suppl.1 )   211 - 211   2024.7

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    Language：Japanese   Publisher：(一社)日本臨床化学会  

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  • Effect of Antimicrobial Photodynamic Therapy on the Tongue Dorsum on Reducing Halitosis and the Duration of the Effect: A Randomized Clinical Trial. Reviewed International journal

    Takayuki Maruyama, Daisuke Ekuni, Aya Yokoi, Junichiro Nagasaki, Nanami Sawada, Manabu Morita

    Healthcare (Basel, Switzerland)   12 ( 10 )   2024.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Antimicrobial photodynamic therapy (PDT) is a treatment that is gaining popularity in modern clinical medicine. However, little is known about the effect of PDT alone on reducing oral halitosis and the duration of the effect. This trial examined the effect of PDT on the tongue dorsum on reducing oral halitosis and the duration of the effect. This study was approved by the Ethics Committee of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, and Okayama University Hospital (CRB20-015), and it was registered in the Japan Registry of Clinical Trials (jRCTs061200060). Twenty-two participants were randomly assigned to two groups: an intervention group and control group. PDT was performed in the intervention group using red laser emission and methylene blue gel on the middle and posterior area of the tongue dorsum. The concentration of volatile sulfur compounds, bacterial count on the tongue dorsum, probing pocket depth, bleeding on probing, and simplified oral debris index score were determined before and 1 week after PDT. The Mann-Whitney U test was used to assess the significance of the differences in each parameter between the two groups. We found that the hydrogen sulfide concentration and bacterial count on the tongue dorsum were decreased in the intervention group, but there was no statistically significant difference between the two groups. These results indicated that performing only PDT on the tongue dorsum may not contribute to reducing halitosis.

    DOI： 10.3390/healthcare12100980

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  • 歯周状態と唾液エクソソーム中miRNAとの関係 横断研究

    澤田 ななみ, 福原 大樹, 角田 伊知郎, 中原 桃子, 外山 直樹, 横井 彩, 竹内 倫子, 丸山 貴之, 江國 大輔

    口腔衛生学会雑誌   74 ( 増刊 )   141 - 141   2024.4

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  • マウスモデルにおける歯周病と糖尿病がアルツハイマー病に与える影響

    中原 桃子, 福原 大樹, Mohammad Nurhamim, Zhang Yixuan, 丸山 貴之, 江國 大輔

    口腔衛生学会雑誌   74 ( 増刊 )   153 - 153   2024.4

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  • サルコペニアと口腔機能との関連(横断研究)

    稲田 さくら, 竹内 倫子, 澤田 ななみ, 外山 直樹, 横井 彩, 丸山 貴之, 角田 伊知郎, 福原 大樹, 森田 学, 江國 大輔

    口腔衛生学会雑誌   74 ( 1 )   60 - 60   2024.1

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  • Effects of Bacillus subtilis on periodontitis in a mouse model(タイトル和訳中)

    Zhang Yixuan, Mohammad Nurhamim, 中原 桃子, 福原 大樹, 丸山 貴之, 江國 大輔

    岡山歯学会雑誌   42 ( 2 )   76 - 76   2023.12

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  • 口腔支持療法により外来放射線治療を完遂できた口腔癌3症例

    武田 斉子, 有村 友紀, 田村 庄平, 中辻 和樹, 三上 彩可, 松崎 秀信, 丸山 貴之, 横井 彩, 天野 克比古, 水川 展吉, 飯田 征二

    日本口腔ケア学会雑誌   17 ( 3 )   242 - 242   2023.4

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  • 大学生における歯周病発症と受動喫煙を含む危険因子との関係 コホート研究

    内田 悠理香, 江國 大輔, 竹内 倫子, 丸山 貴之, 横井 彩, 福原 大樹, 福原 瑶子, 外山 直樹, 澤田 ななみ, 中島 千穂, 中原 桃子, 角田 伊知郎, 森田 学

    口腔衛生学会雑誌   73 ( 増刊 )   149 - 149   2023.4

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  • 大学生における主観的口腔健康評価の傾向と,口腔健康状態および口腔保健行動との関連性

    中原 桃子, 外山 直樹, 江國 大輔, 竹内 倫子, 丸山 貴之, 横井 彩, 福原 大樹, 澤田 ななみ, 中島 千穂, 森田 学

    岡山歯学会雑誌   41 ( 2 )   61 - 61   2022.12

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  • The Impact of Oral Health Behaviors, Health Belief Model, and Absolute Risk Aversion on the Willingness of Japanese University Students to Undergo Regular Dental Check-Ups: A Cross-Sectional Study Reviewed International journal

    Ichiro Sumita, Naoki Toyama, Daisuke Ekuni, Takayuki Maruyama, Aya Yokoi, Daiki Fukuhara, Yoko Uchida-Fukuhara, Momoko Nakahara, Manabu Morita

    International Journal of Environmental Research and Public Health   19 ( 21 )   13920 - 13920   2022.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Oral health behaviors, risk aversion, and the health belief model are associated with health behaviors. However, there have been few studies that investigated the association between these factors and the willingness to undergo regular dental check-ups. The purpose of this cross-sectional study was to investigate the associations between the willingness of Japanese university students to undergo regular dental check-ups and oral health behaviors, the health belief model, and absolute risk aversion. An analysis was conducted with the cooperation of questionnaire respondents (n = 748) who underwent dental check-ups at Okayama University. The students answered questionnaires on oral health behaviors, the health belief model, absolute risk aversion, and willingness to undergo regular dental check-ups. The logistic regression analysis showed significant positive associations (p < 0.05) between oral health behaviors (use of the inter-dental brush and the dental floss) and the health belief model with the willingness to undergo regular dental check-ups. However, there was no significant association with absolute risk aversion (p > 0.05). These results suggest that willingness to undergo regular dental check-ups was associated with oral health behaviors and the health belief model, but not with absolute risk aversion.

    DOI： 10.3390/ijerph192113920

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  • Trends in Self-Rated Oral Health and Its Associations with Oral Health Status and Oral Health Behaviors in Japanese University Students: A Cross-Sectional Study from 2011 to 2019. Reviewed International journal

    Momoko Nakahara, Naoki Toyama, Daisuke Ekuni, Noriko Takeuchi, Takayuki Maruyama, Aya Yokoi, Daiki Fukuhara, Nanami Sawada, Yukiho Nakashima, Manabu Morita

    International journal of environmental research and public health   19 ( 20 )   2022.10

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    Self-rated oral health (SROH) is a valid, comprehensive indicator of oral health status. The purpose of this cross-sectional study was to analyze how oral health behaviors and clinical oral status were associated with SROH and how they had changed over the course of nine years in Japanese university students. Data were obtained from 17,996 students who underwent oral examinations and completed self-questionnaires from 2011 to 2019. Oral status was assessed using the decayed and filled teeth scores, bleeding on probing (BOP), probing pocket depth, the Oral Hygiene Index-Simplified (OHI-S), oral health behaviors, and related factors. SROH improved from 2011 to 2019. The logistic regression model showed that university students who were female and had a high daily frequency of tooth brushing, no BOP, no decayed teeth, no filled teeth, and a low OHI-S score and were significantly more likely to report very good, good, or fair SROH. An interaction effect was observed between survey year and regular dental check-ups (year × regular dental check-ups). The improvement trend in SROH might be associated with changes in oral health behaviors and oral health status.

    DOI： 10.3390/ijerph192013580

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  • Relationship between Psychological Stress Determined by Voice Analysis and Periodontal Status: A Cohort Study. Reviewed International journal

    Takayuki Maruyama, Daisuke Ekuni, Masakazu Higuchi, Eiji Takayama, Shinichi Tokuno, Manabu Morita

    International journal of environmental research and public health   19 ( 15 )   2022.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    In modern society, evaluation and management of psychological stress may be important for the prevention of periodontal disease. The purpose of this study was to examine the relationship between psychological stress (vitality and mental activity) evaluated by Mind Monitoring System (MIMOSYS) and periodontal status. Forty students of Okayama University underwent the oral examination and self-reported questionnaire on the first day (baseline) and the 14th day (follow-up). Voice recording was performed every day with the MIMOSYS app during the whole study period. The participants completed the Patient Health Questionnaire (PHQ)-9 and Beck Depression Inventory (BDI) at baseline and at follow-up. Spearman's rank correlation coefficient was used to determine the significance of correlations among variables. The PHQ-9 and BDI scores were negatively correlated with vitality in the morning. Change in vitality in the morning was significantly correlated with changes in periodontal inflammation. Mental activity was significantly correlated with change in mean probing pocket depth. This result shows that measurement of psychological stress using a voice-based tool to assess mental health may contribute to the early detection of periodontal disease.

    DOI： 10.3390/ijerph19159489

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  • Association between serum miRNAs and gingival gene expression in an obese rat model Reviewed

    Takayuki Maruyama, Terumasa Kobayashi, Yoshio Sugiura, Toshiki Yoneda, Daisuke Ekuni, Manabu Morita

    Journal of Periodontal Research   57 ( 3 )   502 - 509   2022.6

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    DOI： 10.1111/jre.12979

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  • 舌背への光線力学療法による口臭の改善効果の検討 ランダム化比較試験

    長崎 潤一郎, 丸山 貴之, 横井 彩, 江國 大輔, 澤田 ななみ, 森田 学

    口腔衛生学会雑誌   72 ( 増刊 )   81 - 81   2022.4

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  • コロナ禍前とコロナ禍における大学生の睡眠時ブラキシズムの検討(横断研究)

    江國 大輔, 丸山 貴之, 横井 彩, 福原 大樹, 外山 直樹, 澤田 ななみ, 中原 桃子, 角田 伊知郎, 森田 学

    口腔衛生学会雑誌   72 ( 増刊 )   79 - 79   2022.4

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  • 周術期のガム咀嚼トレーニングは胸部食道がん患者の咀嚼能力を維持・向上させる

    山中 玲子, 白川 靖博, 横井 彩, 中村 吉秀, 難波 奏人, 田辺 俊介, 野間 和広, 清水 一好, 内田 悠理香, 吉冨 愛子, 丸山 貴之, 江國 大輔, 森田 学

    口腔衛生学会雑誌   72 ( 増刊 )   101 - 101   2022.4

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  • 大学病院における口腔ケア 岡山大学病院頭頸部がんセンターにおける顎骨再建後のインプラントと口腔ケアの重要性

    水川 展吉, 武田 斉子, 木股 敬裕, 松本 洋, 安藤 瑞生, 丸山 貴之, 佐々木 禎子, 田中 祐貴, 上田 明広, 飯田 征二

    日本口腔ケア学会雑誌   16 ( 3 )   83 - 83   2022.4

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  • 家庭での毎日の受動喫煙曝露は大学生の歯周病と関係する(横断研究)

    江國 大輔, 竹内 倫子, 丸山 貴之, 横井 彩, 福原 大樹, 外山 直樹, イスラム・モハマド・モニルル, 澤田 ななみ, 中原 桃子, 中島 千穂, 出口 純也, 福原 瑶子, 森田 学

    口腔衛生学会雑誌   72 ( 1 )   54 - 54   2022.1

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  • 岡山大学新入生の口腔健康状態および主観的口腔健康評価の9年間の変化

    中原 桃子, 外山 直樹, 江國 大輔, 竹内 倫子, 丸山 貴之, 横井 彩, 福原 大樹, イスラム・モハマド・モニルル, 澤田 ななみ, 中島 千穂, 出口 純也, 森田 学

    口腔衛生学会雑誌   72 ( 1 )   54 - 54   2022.1

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  • Detection of Salivary miRNAs That Predict Chronic Periodontitis Progression: A Cohort Study. Reviewed International journal

    Kohei Fujimori, Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Yoshio Sugiura, Manabu Morita

    International journal of environmental research and public health   18 ( 15 )   2021.7

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    The aim of this two-year cohort study was to investigate salivary microRNAs (miRNAs) that predict periodontitis progression. A total of 120 patients who underwent supportive periodontal therapy were recruited. Unstimulated whole saliva was collected at baseline. Two years later, 44 patients were followed up (median age, 67.1 years) and divided into two groups: progression group (n = 22), with one or more sites with clinical attachment level (CAL) progression (>3 mm compared with baseline) or tooth extraction due to periodontitis progression; and the control group (n = 22), which did not exhibit CAL progression. In the microarray analysis of salivary miRNAs, hsa-miR-5571-5p, hsa-miR-17-3p, hsa-let-7f-5p, hsa-miR-4724-3p, hsa-miR-99a-5p, hsa-miR-200a-3p, hsa-miR-28-5p, hsa-miR-320d, and hsa-miR-31-5p showed fold change values <0.5 or ≥2.0 in the progression group compared with the control group (p < 0.05). On receiver operating characteristic curve analysis, areas under the curves of hsa-miR-5571-5p, hsa-let-7f-5p, hsa-miR-99a-5p, hsa-miR-28-5p, and hsa-miR-320d were >0.7, indicating fair discrimination power. The expressions of salivary hsa-miR-5571-5p, hsa-let-7f-5p, hsa-miR-99a-5p, hsa-miR-28-5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis. These salivary miRNAs may be new biomarkers for progression of periodontitis, and monitoring them may contribute to new diagnostics and precision medicine for periodontitis.

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  • Parafunctional masseter muscle activity during waking is related to periodontitis progression: A pilot prospective cohort study. Reviewed International journal

    Daisuke Ekuni, Seiya Kato, Shigehisa Kawakami, Takayuki Maruyama, Kota Kataoka, Yoko Uchida-Fukuhara, Daiki Fukuhara, Naoki Toyama, Aya Yokoi, Md Monirul Islam, Subrina Binta Khair, Naoki Kodama, Manabu Morita

    Journal of clinical periodontology   48 ( 6 )   785 - 794   2021.6

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    AIM: The purpose of this pilot prospective cohort study was to investigate the effects of parafunctional masseter muscle activity on periodontitis progression among patients receiving supporting periodontal therapy (SPT). MATERIALS AND METHODS: We collected data of patients treated at Okayama University Hospital from August 2014 to September 2018. The progression group was defined as patients with ≥2 teeth demonstrating a longitudinal loss of proximal attachment of ≥3 mm during the 3-year study period and/or at least one tooth extraction due to periodontitis progression. Surface electromyography of masseter muscles at baseline was continuously recorded while patients were awake and asleep. RESULTS: We analysed 48 patients (36 females) aged 66.8 ± 9.1 years (mean ± SD). The rate of parafunctional masseter muscle activity during waking hours and sleeping hours at baseline was 60.4% and 52.1%, respectively. Cox's proportional hazards regression model showed that the incidence of periodontitis progression was significantly associated with number of teeth present (p = 0.001) and parafunctional masseter muscle activity during waking hours (p = 0.041). CONCLUSION: Our results suggest that parafunctional masseter muscle activity during waking hours is a risk factor for periodontitis progression among patients receiving SPT.

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jcpe.13432

  • 噛みたばこ習慣のあるミャンマーでの口腔がん検診

    水川 展吉, Swe Swe Win, 加藤 昌, 丸山 貴之, 山近 英樹, 木股 敬裕, 飯田 征二

    頭頸部癌   47 ( 2 )   244 - 244   2021.5

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  • 「口臭による日常生活への支障」に関連する要因

    佐保 輝, 横井 彩, 丸山 貴之, 竹内 倫子, 江國 大輔, 森田 学

    日本口臭学会会誌   12 ( 1 )   11 - 17   2021.5

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  • 「口臭による日常生活への支障」に関連する要因

    佐保 輝, 横井 彩, 丸山 貴之, 竹内 倫子, 江國 大輔, 森田 学

    日本口臭学会会誌   12 ( 1 )   49 - 50   2021.5

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  • 岡山大学病院頭頸部がんセンターにおける頭頸部がん支持療法に関する臨床実習教育の取り組みについて

    丸山 貴之, 横井 彩, 中原 桃子, 佐々木 禎子, 梶谷 明子, 藤代 万由, 中本 美保, 吉田 陽子, 森田 学, 三浦 留美, 山中 玲子, 水川 展吉, 浅海 淳一, 安藤 瑞生, 木股 敬裕

    日本口腔ケア学会雑誌   15 ( 3 )   186 - 186   2021.4

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  • ヘルスリテラシーとリスク選好が定期的な歯科健診への受診意志に与える影響

    角田 伊知郎, 森田 学, 江國 大輔, 丸山 貴之, 片岡 広太, 横井 彩, 福原 大樹, 福原 瑶子, 外山 直樹, 中原 桃子

    口腔衛生学会雑誌   71 ( 増刊 )   88 - 88   2021.4

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  • 頭頸部がん治療による口腔機能・QOLへの影響 縦断研究

    横井 彩, 丸山 貴之, 中原 桃子, 山中 玲子, 江國 大輔, 森田 学

    口腔衛生学会雑誌   71 ( 増刊 )   116 - 116   2021.4

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  • 岡山大学病院頭頸部がんセンターにおけるエピシル使用経験について

    武田 斉子, 水川 展吉, 田村 庄平, 岡田 亜由美, 中田 靖章, 横井 彩, 丸山 貴之, 松崎 秀信, 松崎 久美子, 藤代 万由, 佐々木 禎子, 山中 玲子, 安藤 瑞生, 木股 敬裕, 浅海 淳一, 飯田 征二

    日本口腔ケア学会雑誌   15 ( 3 )   172 - 172   2021.4

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  • Effects of Coffee Intake on Oxidative Stress During Aging-related Alterations in Periodontal Tissue Reviewed

    TERUMASA KOBAYASHI, TAKAYUKI MARUYAMA, TOSHIKI YONEDA, HISATAKA MIYAI, TETSUJI AZUMA, TAKAAKI TOMOFUJI, DAISUKE EKUNI, MANABU MORITA

    In Vivo   34 ( 2 )   615 - 622   2020.3

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    DOI： 10.21873/invivo.11815

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  • 慢性歯周炎患者の歯周状態の悪化に関連する唾液中miRNAの探索 コホート研究

    藤森 浩平, 米田 俊樹, 杉浦 嘉雄, 丸山 貴之, 江國 大輔, 東 哲司, 友藤 孝明, 森田 学

    口腔衛生学会雑誌   70 ( 増刊 )   158 - 158   2020.3

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  • Detection of Serum miRNAs Affecting Liver Apoptosis in a Periodontitis Rat Model Reviewed

    YOSHIO SUGIURA, TOSHIKI YONEDA, KOHEI FUJIMORI, TAKAYUKI MARUYAMA, HISATAKA MIYAI, TERUMASA KOBAYASHI, DAISUKE EKUNI, TAKAAKI TOMOFUJI, MANABU MORITA

    In Vivo   34 ( 1 )   117 - 123   2020.1

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  • Relationship between acetaldehyde concentration in mouth air and characteristics of microbiota of tongue dorsum in Japanese healthy adults: a cross-sectional study. Reviewed International journal

    Aya Yokoi, Daisuke Ekuni, Hironobu Hata, Mayu Yamane-Takeuchi, Takayuki Maruyama, Reiko Yamanaka, Manabu Morita

    Journal of applied oral science : revista FOB   27   e20180635   2019.6

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    OBJECTIVE: Acetaldehyde, associated with consumption of alcoholic beverages, is known to be a carcinogen and to be related to the tongue dorsum. The aim of this study was to investigate the relationship between acetaldehyde concentration in mouth air and bacterial characteristics on the tongue dorsum. METHODOLOGY: Thirty-nine healthy volunteers participated in the study. Acetaldehyde concentrations in mouth air were evaluated by a high-sensitivity semiconductor gas sensor. A 16S rRNA gene sequencing technique was used to compare microbiomes between two groups, focusing on the six samples with the highest acetaldehyde concentrations (HG) and the six samples with lowest acetaldehyde concentrations (LG). RESULTS: Acetaldehyde concentration increased in correlation with the increase in bacterial count (p=0.048). The number of species observed in the oral microbiome of the HG was higher than that in the oral microbiome of the LG (p=0.011). The relative abundances of Gemella sanguinis, Veillonella parvula and Neisseria flavescens in the oral microbiome of the HG were higher than those in the oral microbiome of the LG (p<0.05). CONCLUSION: Acetaldehyde concentration in mouth air was associated with bacterial count, diversity of microbiome, and relative abundance of G. sanguinis, V. parvula, and N. flavescens.

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  • Serum microRNAs and chronic periodontitis: A case-control study. Reviewed International journal

    Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Kohei Fujimori, Yoshio Sugiura, Manabu Morita

    Archives of oral biology   101   57 - 63   2019.5

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    OBJECTIVE: An association is present between periodontitis and rates of expression of certain microRNAs (miRNAs) in periodontal tissue. However, the association between periodontitis and miRNA levels in human serum is unknown. We performed a case-control study in patients with chronic periodontitis to investigate serum miRNA levels. DESIGN: We enrolled 30 healthy patients without periodontitis and 30 patients with chronic periodontitis. Participants underwent clinical examination, case selection, and a blood draw from the antecubital vein. Serum miRNA profiles were compared in samples from participants with and without chronic periodontitis using microarray and real-time PCR. RESULTS: Microarray demonstrated seven miRNAs that were expressed <1/1.5 or >1.5 in the control group compared to the periodontitis group (p < 0.05). Real-time PCR showed that hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p were higher in the periodontitis group than the control group (p < 0.05). CONCLUSION: Hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p are candidate serum biomarkers for chronic periodontitis.

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  • Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study. Reviewed International journal

    Kohei Fujimori, Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Hirofumi Mizuno, Yoshio Sugiura, Manabu Morita

    Molecules (Basel, Switzerland)   24 ( 6 )   2019.3

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    The purpose of this cross-sectional pilot study was to find salivary microRNAs (miRNAs) reflecting periodontal condition in chronic periodontitis. One hundred and twenty chronic periodontitis patients (mean age, 68.4 years) participated in the study, from whom unstimulated whole saliva was collected. A multiphase study was conducted to explore salivary miRNAs as biomarkers of periodontitis. At first, a polymerase chain reaction (PCR) array was performed to compare salivary miRNAs profiles in no and mild (no/mild) and severe periodontitis patients. Next, the relative expression of salivary miRNAs on individual samples was assessed by real-time reverse transcription-PCR. The numbers (%) of patients were 26 (21.6%, no/mild), 58 (48.3%, moderate) and 36 (30.0%, severe), respectively. Among 84 miRNAs, only the relative expression of hsa-miR-381-3p in the severe periodontitis group was significantly higher than that of the no/mild periodontitis group (p < 0.05). Among the 120 patients, there was also a significant correlation between the relative expression of hsa-miR-381-3p and the mean probing pocket depth (PPD) (r = 0.181, p < 0.05). Salivary hsa-miR-381-3p was correlated with periodontitis condition in chronic periodontitis patients.

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  • Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer: A Retrospective Cohort Study. Reviewed

    Mizuno H, Miyai H, Yokoi A, Kobayashi T, Inabu C, Maruyama T, Ekuni D, Mizukawa N, Kariya S, Nishizaki K, Kimata Y, Morita M

    In vivo (Athens, Greece)   33 ( 1 )   183 - 189   2019.1

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  • New oral hygiene care regimen reduces postoperative oral bacteria count and number of days with elevated fever in ICU patients with esophageal cancer. Reviewed

    Hirofumi Mizuno, Shinsuke Mizutani, Daisuke Ekuni, Ayano Tabata-Taniguchi, Takayuki Maruyama, Aya Yokoi, Chie Omori, Kazuyoshi Shimizu, Hiroshi Morimatsu, Yasuhiro Shirakawa, Manabu Morita

    Journal of oral science   60 ( 4 )   536 - 543   2018.12

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    Using a controlled pre/post study design, we investigated the effects of professional mechanical cleaning of the oral cavity with benzethonium chloride, interdental brushes, and hydrogen peroxide on the number of oral bacteria and postoperative complications among esophageal cancer patients in an intensive care unit. Before surgery, 44 patients with esophageal cancer were recruited at Okayama Hospital from January through August 2015. The control group (n = 23) received routine oral hygiene care in the intensive care unit. The intervention group (n = 21) received intensive interdental cleaning with benzethonium chloride solution and tongue cleaning with hydrogen peroxide. The number of oral bacteria on the tongue surface and plaque index were significantly lower in the intervention group than in the control group on postoperative days 1 and 2 (P < 0.05). Additionally, the number of days with elevated fever during a 1-week period was significantly lower in the intervention group than in the control group (P = 0.037). As compared with routine oral hygiene, a new oral hygiene regimen comprising benzethonium chloride, interdental brushes, and hydrogen peroxide significantly reduced the number of oral bacteria and days with elevated fever in patients with esophageal cancer.

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  • The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: A randomized clinical trial. Reviewed International journal

    Hirofumi Mizuno, Daisuke Ekuni, Takayuki Maruyama, Kota Kataoka, Toshiki Yoneda, Daiki Fukuhara, Yoshio Sugiura, Takaaki Tomofuji, Jun Wada, Manabu Morita

    PloS one   12 ( 11 )   e0188171   2017.11

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    DOI： 10.1371/journal.pone.0188171

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  • Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats. Reviewed International journal

    Hisataka Miyai, Takayuki Maruyama, Takaaki Tomofuji, Toshiki Yoneda, Tetsuji Azuma, Hirofumi Mizuno, Yoshio Sugiura, Terumasa Kobayashi, Daisuke Ekuni, Manabu Morita

    Archives of oral biology   82   247 - 255   2017.10

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  • Expression of Salivary miR-203a-3p Was Related with Oral Health-Related Quality of Life in Healthy Volunteers. Reviewed International journal

    Terumasa Kobayashi, Takaaki Tomofuji, Tatsuya Machida, Toshiki Yoneda, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Akiko Hirose, Manabu Morita

    International journal of molecular sciences   18 ( 6 )   2017.6

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    DOI： 10.3390/ijms18061263

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  • Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study. Reviewed International journal

    Takayuki Maruyama, Takaaki Tomofuji, Tatsuya Machida, Hironari Kato, Koichiro Tsutsumi, Daisuke Uchida, Akinobu Takaki, Toshiki Yoneda, Hisataka Miyai, Hirofumi Mizuno, Daisuke Ekuni, Hiroyuki Okada, Manabu Morita

    Molecular and clinical oncology   6 ( 5 )   683 - 687   2017.5

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    Several studies have indicated that periodontitis is a risk factor for cancer. However, the association between periodontitis and the prognosis of pancreatobiliary tract cancer remains unclear. The aim of this pilot study was to investigate the association between periodontitis and prognosis of pancreatobiliary tract cancer. A total of 22 patients diagnosed with pancreatobiliary tract cancer were analyzed. Oral health status, including severity of periodontitis, general health status and biochemical serum markers were evaluated. The Kaplan-Meier method and Cox proportional hazards model were used to assess factors affecting the prognosis of pancreatobiliary tract cancer. The Kaplan-Meier analysis demonstrated that low body mass index, high concentration of serum C-reactive protein (CRP) and severe periodontitis were significant prognostic factors for survival rate. The Cox proportional hazards model revealed that serum carbohydrate antigen 19-9 concentration [hazard ratio (HR)=1.002; 95% confidence interval (CI): 1.000-1.004] and serum CRP concentration (HR=2.57; 95% CI: 1.15-5.74) were significantly associated with the prognosis of pancreatobiliary tract cancer. In addition, cancer patients with severe periodontitis had higher serum CRP concentrations compared with those without severe periodontitis. Therefore, severe periodontitis indirectly affected the prognosis of pancreatobiliary tract cancer through promoting systemic inflammation.

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  • The Serum Oxidative/Anti-oxidative Stress Balance Becomes Dysregulated in Patients with Non-alcoholic Steatohepatitis Associated with Hepatocellular Carcinoma. Reviewed

    Yasuyuki Shimomura, Akinobu Takaki, Nozomu Wada, Tetsuya Yasunaka, Fusao Ikeda, Takayuki Maruyama, Naofumi Tamaki, Daisuke Uchida, Hideki Onishi, Kenji Kuwaki, Shinichiro Nakamura, Kazuhiro Nouso, Yasuhiro Miyake, Kazuko Koike, Takaaki Tomofuji, Manabu Morita, Kazuhide Yamamoto, Hiroyuki Okada

    Internal medicine (Tokyo, Japan)   56 ( 3 )   243 - 251   2017

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  • miR‑1246 and miR‑4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer. Reviewed International journal

    Tatsuya Machida, Takaaki Tomofuji, Takayuki Maruyama, Toshiki Yoneda, Daisuke Ekuni, Tetsuji Azuma, Hisataka Miyai, Hirofumi Mizuno, Hironari Kato, Koichiro Tsutsumi, Daisuke Uchida, Akinobu Takaki, Hiroyuki Okada, Manabu Morita

    Oncology reports   36 ( 4 )   2375 - 81   2016.10

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    DOI： 10.3892/or.2016.5021

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  • Oxidative stress balance is dysregulated and represents an additional target for treating cholangiocarcinoma. Reviewed International journal

    Daisuke Uchida, Akinobu Takaki, Hisashi Ishikawa, Yasuko Tomono, Hironari Kato, Koichiro Tsutsumi, Naofumi Tamaki, Takayuki Maruyama, Takaaki Tomofuji, Ryuichiro Tsuzaki, Tetsuya Yasunaka, Kazuko Koike, Hiroshi Matsushita, Fusao Ikeda, Yasuhiro Miyake, Hidenori Shiraha, Kazuhiro Nouso, Ryuichi Yoshida, Yuzo Umeda, Susumu Shinoura, Takahito Yagi, Toshiyoshi Fujiwara, Manabu Morita, Masaki Fukushima, Kazuhide Yamamoto, Hiroyuki Okada

    Free radical research   50 ( 7 )   732 - 43   2016.7

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  • MicroRNAs as serum biomarkers for periodontitis. Reviewed International journal

    Takaaki Tomofuji, Toshiki Yoneda, Tatsuya Machida, Daisuke Ekuni, Tetsuji Azuma, Kota Kataoka, Takayuki Maruyama, Manabu Morita

    Journal of clinical periodontology   43 ( 5 )   418 - 25   2016.5

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    DOI： 10.1111/jcpe.12536

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  • MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging. Reviewed International journal

    Tatsuya Machida, Takaaki Tomofuji, Daisuke Ekuni, Takayuki Maruyama, Toshiki Yoneda, Yuya Kawabata, Hirofumi Mizuno, Hisataka Miyai, Muneyoshi Kunitomo, Manabu Morita

    International journal of molecular sciences   16 ( 9 )   21294 - 309   2015.9

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    DOI： 10.3390/ijms160921294

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  • Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study. Reviewed International journal

    Tetsuji Azuma, Mayu Yamane, Daisuke Ekuni, Yuya Kawabata, Kota Kataoka, Kenta Kasuyama, Takayuki Maruyama, Takaaki Tomofuji, Manabu Morita

    Antioxidants (Basel, Switzerland)   4 ( 3 )   513 - 22   2015.7

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    Oxidative stress is involved in the pathogenesis of periodontitis. A reduction of oxidative stress by drinking hydrogen-rich water (HW) might be beneficial to periodontal health. In this pilot study, we compared the effects of non-surgical periodontal treatment with or without drinking HW on periodontitis. Thirteen patients (3 women, 10 men) with periodontitis were divided into two groups: The control group (n = 6) or the HW group (n = 7). In the HW group, participants consumed HW 4-5 times/day for eight weeks. At two to four weeks, all participants received non-surgical periodontal treatment. Oral examinations were performed at baseline, two, four and eight weeks, and serum was obtained at these time points to evaluate oxidative stress. At baseline, there were no significant differences in periodontal status between the control and HW groups. The HW group showed greater improvements in probing pocket depth and clinical attachment level than the control group at two, four and eight weeks (p < 0.05). The HW group also exhibited an increased serum level of total antioxidant capacity at four weeks, compared to baseline (p < 0.05). Drinking HW enhanced the effects of non-surgical periodontal treatment, thus improving periodontitis.

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  • Relationship between acetaldehyde concentration in mouth air and tongue coating volume Reviewed

    Aya Yokoi, Takayuki Maruyama, Reiko Yamanaka, Daisuke Ekuni, Takaaki Tomofuji, Haruhiko Kashiwazaki, Yutaka Yamazaki, Manabu Morita

    JOURNAL OF APPLIED ORAL SCIENCE   23 ( 1 )   64 - 70   2015.1

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  • Serum Oxidative/anti-oxidative Stress Balance Is Dysregulated in Potentially Pulmonary Hypertensive Patients with Liver Cirrhosis: A Case Control Study. Reviewed

    Masako Terao, Akinobu Takaki, Takayuki Maruyama, Hiroki Oe, Tetsuya Yasunaka, Naofumi Tamaki, Kazufumi Nakamura, Takaaki Tomofuji, Takahito Yagi, Hiroshi Sadamori, Yuzo Umeda, Susumu Shinoura, Ryuichi Yoshida, Kazuhiro Nouso, Daisuke Ekuni, Kazuko Koike, Fusao Ikeda, Hidenori Shiraha, Manabu Morita, Hiroshi Ito, Toshiyoshi Fujiwara, Kazuhide Yamamoto

    Internal medicine (Tokyo, Japan)   54 ( 22 )   2815 - 26   2015

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  • Severe periodontitis is inversely associated with coffee consumption in the maintenance phase of periodontal treatment. Reviewed International journal

    Tatsuya Machida, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Noriko Takeuchi, Takayuki Maruyama, Shinsuke Mizutani, Kota Kataoka, Yuya Kawabata, Manabu Morita

    Nutrients   6 ( 10 )   4476 - 90   2014.10

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  • アルコール摂取後のブラッシング行動と歯周病の活動性との関連

    水谷 慎介, 江國 大輔, 友藤 孝明, 山根 真由, 東 哲司, 丸山 貴之, 町田 達哉, 米田 俊樹, 片岡 広太, 佐久本 雅美, 川端 勇也, 大森 智栄, 森田 学

    口腔衛生学会雑誌   64 ( 2 )   173 - 173   2014.4

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  • Occlusion and Weight Change in a Patient After Esophagectomy: Success Derived from Restoration of Occlusal Support Reviewed

    Reiko Yamanaka, Yoshihiko Soga, Mami Minakuchi, Kumiko Nawachi, Takayuki Maruyama, Takuo Kuboki, Manabu Morita

    INTERNATIONAL JOURNAL OF PROSTHODONTICS   26 ( 6 )   574 - 576   2013.11

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    DOI： 10.11607/ijp.3622

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  • Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma. Reviewed International journal

    Mamoru Nishimura, Akinobu Takaki, Naofumi Tamaki, Takayuki Maruyama, Hideki Onishi, Sayo Kobayashi, Kazuhiro Nouso, Tetsuya Yasunaka, Kazuko Koike, Hiroaki Hagihara, Kenji Kuwaki, Shinichiro Nakamura, Fusao Ikeda, Yoshiaki Iwasaki, Takaaki Tomofuji, Manabu Morita, Kazuhide Yamamoto

    Hepatology research : the official journal of the Japan Society of Hepatology   43 ( 10 )   1078 - 92   2013.10

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    DOI： 10.1111/hepr.12048

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  • Relationship between serum albumin concentration and periodontal condition in patients with head and neck cancer. Reviewed International journal

    Takayuki Maruyama, Reiko Yamanaka, Aya Yokoi, Daisuke Ekuni, Takaaki Tomofuji, Nobuyoshi Mizukawa, Tomoo Onoda, Motoharu Eguchi, Manabu Morita

    Journal of periodontology   83 ( 9 )   1110 - 5   2012.9

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    DOI： 10.1902/jop.2011.110536

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  • Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats. Reviewed

    Takaaki Tomofuji, Daisuke Ekuni, Koichiro Irie, Tetsuji Azuma, Naofumi Tamaki, Takayuki Maruyama, Tatsuo Yamamoto, Tatsuo Watanabe, Manabu Morita

    Biomedical research (Tokyo, Japan)   32 ( 5 )   343 - 9   2011.10

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  • Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. Reviewed International journal

    Takayuki Maruyama, Takaaki Tomofuji, Yasumasa Endo, Koichiro Irie, Tetsuji Azuma, Daisuke Ekuni, Naofumi Tamaki, Tatsuo Yamamoto, Manabu Morita

    Archives of oral biology   56 ( 1 )   48 - 53   2011.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.archoralbio.2010.08.015

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  • Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats. Reviewed International journal

    Takaaki Tomofuji, Daisuke Ekuni, Toshihiro Sanbe, Tetsuji Azuma, Naofumi Tamaki, Koichiro Irie, Takayuki Maruyama, Tatsuo Yamamoto, Tatsuo Watanabe, Mutsumi Miyauchi, Takashi Takata

    Acta odontologica Scandinavica   67 ( 4 )   200 - 5   2009.7

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    DOI： 10.1080/00016350902794818

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  • Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress. Reviewed International journal

    Daisuke Ekuni, Takaaki Tomofuji, Toshihiro Sanbe, Koichiro Irie, Tetsuji Azuma, Takayuki Maruyama, Naofumi Tamaki, Jun Murakami, Susumu Kokeguchi, Tatsuo Yamamoto

    Archives of oral biology   54 ( 5 )   495 - 502   2009.5

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    DOI： 10.1016/j.archoralbio.2009.02.006

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  • Validity of a questionnaire for periodontitis screening of Japanese employees. Reviewed International journal

    Tatsuo Yamamoto, Reiko Koyama, Naofumi Tamaki, Takayuki Maruyama, Takaaki Tomofuji, Daisuke Ekuni, Reiko Yamanaka, Tetsuji Azuma, Manabu Morita

    Journal of occupational health   51 ( 2 )   137 - 43   2009.3

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    DOI： 10.1539/joh.l8108

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  • Effects of vitamin C intake on gingival oxidative stress in rat periodontitis. Reviewed International journal

    Takaaki Tomofuji, Daisuke Ekuni, Toshihiro Sanbe, Koichiro Irie, Tetsuji Azuma, Takayuki Maruyama, Naofumi Tamaki, Jun Murakami, Susumu Kokeguchi, Tatsuo Yamamoto

    Free radical biology & medicine   46 ( 2 )   163 - 8   2009.1

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    DOI： 10.1016/j.freeradbiomed.2008.09.040

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  • Oxidative damage of rat liver induced by ligature-induced periodontitis and chronic ethanol consumption. Reviewed International journal

    Takaaki Tomofuji, Toshihiro Sanbe, Daisuke Ekuni, Tetsuji Azuma, Koichiro Irie, Takayuki Maruyama, Naofumi Tamaki, Tatsuo Yamamoto

    Archives of oral biology   53 ( 12 )   1113 - 8   2008.12

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    DOI： 10.1016/j.archoralbio.2008.05.015

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  • Relationship between periodontal condition and plasma reactive oxygen metabolites in patients in the maintenance phase of periodontal treatment. Reviewed International journal

    Naofumi Tamaki, Takaaki Tomofuji, Takayuki Maruyama, Daisuke Ekuni, Reiko Yamanaka, Noriko Takeuchi, Tatsuo Yamamoto

    Journal of periodontology   79 ( 11 )   2136 - 42   2008.11

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    DOI： 10.1902/jop.2008.080082

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  • Effects of Ethanol Consumption on Periodontal Inflammation in Rats Reviewed

    K. Irie, T. Tomofuji, N. Tamaki, T. Sanbe, D. Ekuni, T. Azuma, T. Maruyama, T. Yamamoto

    Journal of Dental Research   87 ( 5 )   456 - 460   2008.5

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    Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

    DOI： 10.1177/154405910808700511

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    Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/154405910808700511

  • Relationship between periodontal status and levels of oxidative stress and antioxidant potential in plasma

    Maruyama Takayuki, Tamaki Naofumi, Tomofuji Takaaki, Ekuni Daisuke, Yamanaka Reiko, Takeuchi Noriko, Yamamoto Tatsuo

    Program and Abstracts of Annual Meeting of the Japanese Society of Periodontology   2008   52 - 52   2008

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    Language：Japanese   Publisher：JAPANESE SOCIETY OF PERIODONTOLOGY  

    DOI： 10.14833/amjsp.2008s.0.52.0

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Awards

  • Academic awards of The Japanese Society for Oral Health "LION AWARD"

    2024.5   The Japanese Society for Oral Health   Association between serum miRNAs and gingival gene expression in an obese rat model

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Research Projects

  • Improving Alzheimer's Disease through the Application of Probiotics

    Grant number：24K13278  2024.04 - 2027.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    森田 学, 丸山 貴之, 江國 大輔

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    Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）

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  • 摂食嚥下療法は頭頸部がんサバイバーの復職支援となりうるか？

    Grant number：21K10209  2021.04 - 2024.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    横井 彩, 丸山 貴之, 江國 大輔, 森田 学, 山中 玲子

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    Grant amount：\3640000 （ Direct expense: \2800000 、 Indirect expense：\840000 ）

    本研究の目的は、頭頸部がんに対する治療を終了した頭頸部がんサバイバーにおいて、①術後の早期復職に関連する口腔機能の特定と、②術後早期からの嚥下訓練による早期復職・QOLへの影響について明らかにすることである。
    令和3年度では、頭頸部がんサバイバーにおいて就労状況と、QOL、口腔機能との関係について明らかにした。具体的には、口腔ケア目的に予防歯科外来を受診した頭頸部がんサバイバーに対し、以下の項目について評価した。１，就労状況（就労日数・時間）、２，QOL（自己記述式アンケート）、３，口腔機能（舌を押し上げる力、口の開き具合、口の中の粘膜の水分量、かみ合わせ、舌上の細菌の量、自己記述式アンケート）。対象者95名のうち、39名ががん治療後に復職していた。仕事をしているがんサバイバー28名と、仕事をしていないがんサバイバー28名との間で、QOLと口腔機能を比較した。
    統計解析の結果、仕事をしていないがんサバイバーは、仕事をしているがんサバイバーと比較し、再発や転移などで再手術を受けた者の割合が高く、QOLが低かった。また、仕事をしていないがんサバイバーは、仕事をしているがんサバイバーと比較し、嚥下機能の指標となる「舌を押し上げる力（舌圧）」は同程度であるものの、口腔機能に関するアンケート調査において、「嚥下機能に問題がある」と答えた者の割合が高かった。

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  • Regulation of microRNAs that transmit information from gingival tissue to systemic organs

    Grant number：21K10207  2021.04 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    森田 学, 丸山 貴之, 江國 大輔, 友藤 孝明, 片岡 広太

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    Grant amount：\4160000 （ Direct expense: \3200000 、 Indirect expense：\960000 ）

    歯周病は、歯周組織の炎症性疾患である。また、歯周病は様々な全身疾患に影響することが知られている。しかし、歯周病が、どのような機序で全身臓器に影響するかについては不明な点が多い。
    microRNAは、17～25塩基対からなる短鎖ノンコーディングRNAであり、互いに部分相補的な遺伝子配列を持つメッセンジャー RNA（mRNA）に結合し、その遺伝子発現を制御する。本研究では、歯周病由来の特定の血清microRNAが、全身臓器のmRNAの遺伝子発現を制御し、病変を引き起こすという仮説を立て、候補となる血清microRNAを特定することを目的とした。
    ラットを用いて、歯周病を人工的に惹起させる群（実験群、8匹）と何もしない群（対照群、8匹）に分け4週間飼育した。まず肝臓に注目したところ、実験群でアポトーシスが認められた。また、2群間で、血清中の発現量が著しく異なるmicroRNA52種類と肝臓で発現量が著しく異なるmRNA33種類がスクリーニングされた。バイオインフォマティクス解析の結果、肝臓mRNAのうち、12種類（Gpr12、Hyou1、Rgma、Rad51、Dusp4、Chac1、Ier5、Ybx3、Pard6g、Bloc1s3、Sephs2、Il7）は、変動した血清miRNA （発現量比 >1.5、<0.67）の標的遺伝子と一致していることが判明した。そのうち、Hyou1、Chac1、Bloc1s3は、アポトーシスに関わる作用を有しており、これら3種類の肝臓mRNAの上流に存在する血清microRNAは、miR-3591、miR-181a-2-3p、miR-6321であった。
    以上のことから、歯周病モデルラットにおいて、miR-3591、miR-181a-2-3p、miR-6321は、肝臓mRNAであるHyou1、Chac1、Bloc1s3の遺伝子発現を制御し、肝細胞のアポトーシスを引き起こした可能性が示唆された。

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  • 乳酸菌の継続摂取による口腔細菌叢の質的量的分析と関連する唾液バイオマーカーの模索

    Grant number：21K10252  2021.04 - 2024.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    佐保 輝, 丸山 貴之, 森田 学, 江國 大輔

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    Grant amount：\4030000 （ Direct expense: \3100000 、 Indirect expense：\930000 ）

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  • 次世代型アルツハイマー病モデルにおける酸化ストレス制御に着目した認知症予防の検討

    Grant number：21K10227  2021.04 - 2022.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    片岡 広太, 江國 大輔, 福原 大樹, 丸山 貴之, 中原 桃子, 福原 瑶子, 森田 学

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    Grant amount：\4030000 （ Direct expense: \3100000 、 Indirect expense：\930000 ）

    アルツハイマー型認知症は加齢に伴って増加する神経変性疾患であり、症状の進行により最終的には寝たきり介護が必要な状態となる。脳内のアミロイドβの集積による神経毒性が疾患プロセスの中心とされているが、有効な治療法や、緩和方法が確立されていないのが現状である。神経変性の病態は未だ解明されていないが、アルツハイマー型認知症モデルマウスにおいて、抗酸化遺伝子の誘導が酸化ストレスと神経変性を抑制することが示された。近年、歯周病がマウスの脳細胞へのアミロイドβの蓄積量を増加させるがことが報告されている。歯周病の病態にも酸化ストレスが関与するが、歯周病に由来するアミロイドβの蓄積に酸化ストレスがどの程度関係するかは不明である。本研究では、アルツハイマー型認知症モデルマウスにおいて、歯周病由来のアミロイドβの蓄積に対する酸化ストレスの役割を検討して、抗酸化療法の予防効果について検討した。
    初年度は、最適なモデルを検討することとしていた。そこで、アルツハイマー型認知症モデルマウスを歯周病群と対照群に分けた。歯周病群には、下顎の第1臼歯に絹糸を巻き、歯周病を惹起した。対照群は無処置とした。2か月後に、マウスから脳を摘出した。一部は病理組織標本に用い、一部は遺伝子の抽出に用いた。対照群と比較して、歯周病群では脳内の酸化ストレスに関与する遺伝子が一部変動していた。脳内の2倍以上の変動があった316個の遺伝子群のうち、酸化ストレスに関与する遺伝子が2種類含まれていた。また、免疫染色の結果、海馬におけるアミロイドβの増加もみられた。

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  • がん化学療法に伴う歯周組織への影響に関する検討

    Grant number：20K10267  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    丸山 貴之, 森田 学, 江國 大輔, 小林 暉政, 杉浦 嘉雄

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    Grant amount：\4420000 （ Direct expense: \3400000 、 Indirect expense：\1020000 ）

    本研究の目的は、がん化学療法に用いられる5-フルオロウラシル（5-FU）投与による歯科疾患の重症化メカニズムについて、動物実験を行い、組織学的、生化学的な観点から解明することである。また、5-FU投与による歯周疾患の重症化に対する予防法についても検討する。
    2021年度は予備実験として、別研究（酸化ストレス可視化マウスによる抗がん剤の酸化ストレスの検討）で得られた血液および歯周組織を用いて、酸化ストレスの程度を比較検討した。マウスを3群（①コントロール群、②生理食塩水腹腔内投与群、③5-FU腹腔内投与群）に分類し、それぞれの処置を行った。1週間後、すべての群のマウスを多量のイソフルレンで安楽死させ、血液および歯周組織を採取した。その後、血清中および歯周組織中の酸化ストレスを測定し、比較検討した。
    その結果、5-FU腹腔内投与群はコントロール群、生理食塩水腹腔内投与群と比較して、血清中および歯周組織中の酸化ストレスが高い傾向を認めた。一方、コントロール群と生理食塩水腹腔内投与群の間で、血清中および歯周組織中の酸化ストレスに大きな違いは認められなかった。このことから、5-FU投与により、血清中の酸化ストレスが増加し、その酸化ストレスが歯周組織に影響を及ぼすことで、歯周状態を悪化する可能性が示唆された。

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  • gum chewing during postoperative fasting improve the prognosis after esophageal cancer surgery?

    Grant number：19K10444  2019.04 - 2023.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    山中 玲子, 横井 彩, 森田 学, 丸山 貴之

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    Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

    本研究は，「胸部食道がん患者における周術期のガム咀嚼と舌圧との関連」を明らかにし、食道がん術後合併症予防に寄与する方策を歯科的に検討するものである。
    科研申請時は、食道がん手術を受ける患者を対象に，術後絶食期間中に，従来の口腔衛生管理のみを行う「対照群」と，術後絶食中にガム咀嚼による口腔機能訓練を加えて行う「介入群」にランダムに割付け，2群間で比較して，食道がん術後絶食中のガム咀嚼による咀嚼機能や嚥下機能の維持効果，予後改善効果を検討するランダム化比較試験（必要症例数約70例）としていた。その後、具体的な研究方法について、倫理委員会、各科の医師・歯科医師、パラメディカル、統計専門家等と議論し、過去の我々の研究でえた結果を対照群とし、周術期にガム咀嚼を行う1群のみの介入研究とすることとなった。
    我々の過去の研究では，食道がん術後2週間目に舌圧が低下した患者の割合は64.5%程度（38人/59人中）であったため，期待割合：40％，閾値割合：65％で計算すると，24症例で10人低下（41.7%）の場合，信頼区間は22.1%～63.3%で，両側p値＝0.03，24症例で9人低下（37.5%）の場合，信頼区間は18.8%～59.4%で，両側p値=0.01となり，必要症例数は24例となった。また，過去の研究では，92名が参加して33名（35.9%）が同意撤回，中止，脱落したため，36%が脱落すると仮定し，その分も加味すると必要症例数は38例となる。今回，40例あれば，同意撤回，中止，脱落等が生じても，統計学的考察も可能と考えられるため，目標症例数は40例とした。
    令和3年度は、37症例を登録し、30症例が完了した。22症例を収集した時点で、中間解析を行ったところ、ガム咀嚼トレーニングを行った群では、有意に舌圧の低下を予防できたことを確認した。結果はがん口腔支持療法学会で発表した。
    令和4年度中に対象者の募集を終え、最終解析、学会発表、論文発表を行う予定である。

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  • Multifactorial analysis for progression of oral frail

    Grant number：17H04421  2017.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Morita Manabu

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    Grant amount：\13130000 （ Direct expense: \10100000 、 Indirect expense：\3030000 ）

    This clinical study determined the oral function which related to the physical frailty. A total of 203 outpatients of Preventive Dentistry Clinic at Okayama University Hospital participated. The path analysis, in the cross sectional study, revealed that ODK was positively associated with nutritional status. In addition, there was a negative association between nutritional status and the number of criterion met in physical frailty, and a positive association between nutritional status and walking distance without rest. In the cohort study, keeping good ODK was significantly associated mainly with confidence not falling, followed by the tongue pressure, masticatory function, swallowing function and number of present teeth. We concluded that articulatory oral motor skill, social participation and physical frailty were associated to each other in the aging process.

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  • Mechanism of periodontal disease on disease progression of non-alcoholic steatohepatitis

    Grant number：17K17371  2017.04 - 2019.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Maruyama Takayuki

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    Grant amount：\3640000 （ Direct expense: \2800000 、 Indirect expense：\840000 ）

    Non-alcoholic hepatitis (NASH) can be a risk factor for periodontal disease, however, the mechanism that NASH exerts on the pathological progression of periodontal disease is unclear. On the other hand, microRNA in blood serves as a communication medium for systemic disease and periodontal disease. The purpose of this study was to clarify the influence of NASH on periodontal tissue by pairing analysis of microRNA in blood and gene expression in periodontal tissue. As a result, it is suggested that NASH regulates gene expression in periodontal tissue via microRNA in blood.

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  • Biomarker to reflect for condition of periodontitis

    Grant number：16K11855  2016.04 - 2019.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Miyai Hisataka

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    Grant amount：\4420000 （ Direct expense: \3400000 、 Indirect expense：\1020000 ）

    The purpose of this study is to explore serum miRNAs which reflect periodontal condition and which can influence systematic condition. Wistar rats aged 8-weeks old (n=16) were divided into two groups. Cotton ligature was placed in a submarginal position on the maxillary second molars for 4 weeks to induce periodontitis in periodontitis group. Control groups received no treatment for 4 weeks. Ligation around teeth induced periodontal inflammation and periodontal tissue destruction. In serum investigation, microarray and real-time PCR results showed that miR-376b-3p could be biomarker for periodontitis. Microarray of liver and integrated analysis between serum miR-376b and mRNA of liver was examined. Periodontitis could affect the liver through serum miRNAs.

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  • Relation between oral health status and pancreatobiliary tract cancer

    Grant number：26670904  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    Morita Manabu

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    Grant amount：\3640000 （ Direct expense: \2800000 、 Indirect expense：\840000 ）

    Patients diagnosed with pancreatobiliary tract cancer were analyzed. Factors affecting the prognosis of pancreatobiliary tract cancer were evaluated. The results demonstrated that low body mass index, high concentration of serum C-reactive protein (CRP) and severe periodontitis were significant prognostic factors for survival rate. It was also found that micro-RNAs in salivary exosomes could be candidate biomarkers for pancreatobiliary tract cancer.

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  • Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats

    Grant number：26861830  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Maruyama Takayuki

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    Grant amount：\3640000 （ Direct expense: \2800000 、 Indirect expense：\840000 ）

    The purpose of this study was to investigate the preventive effects of topical application of catechins on tongue oxidative stress induced by 5-FU administration in rats. Rats were divided into four groups of seven rats each: a negative control group (saline + ointment without catechins), a positive control group (5-FU + ointment without catechins), and two experimental groups (5-FU + ointment containing 0.1% or 0.5% catechins). Topical application of each ointment to the ventral surface of the tongue was performed once a day for 5 days. The level of 8-OHdG was determined to evaluate oxidative stress.
    The ratios of 8-OHdG positive cells were higher in the positive control group than in the negative control group. On the other hand, those in the 0.5% green tea catechin group, but not in the 0.1% green tea catechin group, were lower than the positive control group.
    Topical application of ointment containing 0.5% catechins could prevent tongue oxidative stress in 5-FU administered rats.

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  • The effectiveness of postoperative continuous oral management in perioperative care

    Grant number：25463242  2013.04 - 2016.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Mizutani Shinsuke, MORITA Manabu, TOMOFUJI Takaaki, EKUNI Daisuke, MARUYAMA Takayuki, YOKOI Aya, TANIGUCHI Ayano, MIZUNO Hirofumi

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    Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）

    The purpose of this study was to determine the effect of professional oral healthcare on postoperative complications after esophagectomy among patients with esophageal cancer.
    Patients were divided into two groups: patients who received professional oral healthcare from dentists after surgery (oral care group, n = 21) and those who did not receive oral healthcare (control group, n = 23).
    Logistic regression analysis showed that the risk for postoperative pyrexia (≧38.0℃) was associated with the lack of professional oral healthcare intervention (Odds ratio: 13.09; 95%confidence interval: 2.04-84.03; P < 0.05) and anastomotic leakage (Odds ratio: 28.15; 95%confidence interval: 2.06-384.25; P < 0.05). This suggests that professional oral healthcare intervention is effective in reducing the incidence of postoperative pyrexia in patients who undergo esophagectomy.

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  • Prevention of cancer by oral care inhibiting the production of acetaldehyde

    Grant number：24593154  2012.04 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOKOI AYA, YAMANAKA Reiko, MORITA Manabu, YAMASAKI Yutaka, KASHIWAZAKI Haruhiko, HATA Hironobu, TOMOFUJI Takaaki, TAMAKI Naofumi, EKUNI Daisuke, MARUYAMA Takayuki, SOGA Yoshihiko

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    Grant amount：\5070000 （ Direct expense: \3900000 、 Indirect expense：\1170000 ）

    The aim of this study was to investigate the relationship between acetaldehyde concentration in mouth air and tongue coating volume in healthy volunteers. Acetaldehyde concentration in participants with a tongue coating score of 3 was significantly higher than those with a score of 1. After removing tongue coating, acetaldehyde concentration was significantly decreased.
    Oral microflora on the tongue may be the main source of local production of acetaldehyde. Removing tongue coating may be a method inhibiting the production of acetaldehyde.

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  • Effectiveness of comprehensive food education (Shokuiku) against the lifestyle-related disease

    Grant number：23593089  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MARUYAMA Takayuki, MORITA Manabu, TOMOFUJI Takaaki, EKUNI Daisuke, YAMANAKA Reiko, TAKEUCHI Noriko

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    Grant amount：\4940000 （ Direct expense: \3800000 、 Indirect expense：\1140000 ）

    Recently, it is noticed the importance of comprehensive food education (Shokuiku) against the lifestyle-related disease. In this study, we investigated whether eating until full, eating quickly, or both eating behaviors were associated with being overweight, the relationship between subjective and objective methods to evaluate eating quickly and to numerically characterize the kinesis of eating quickly. Also, we investigated the effects of intervention using a pamphlet or the combination of a pamphlet and dietary records on improvement of eating quickly. Furthermore, we investigated the relationship between knowledge about comprehensive food education and dental caries experience.

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Class subject in charge

  • Awakening to EBM and professionalism （2024academic year） 1st semester  - 火1,火2,火3

  • Practicals: Oral Health （2024academic year） special  - その他

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  • Lecture and Research Projects: Oral Health II （2024academic year） special  - その他

  • Human Ecology （2024academic year） Fourth semester  - 火3

  • Health Statistics （2024academic year） Second semester  - 水3

  • Public Health （2024academic year） Fourth semester  - 火1,火2

  • Practice in Oral Health Evaluation （2024academic year） 1st semester  - 月5,月6,月7

  • Oral Health （2024academic year） Third semester  - 金2,金3

  • Clinical training: Public Health Dentistry （2024academic year） special  - その他

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  • Etiology of Oral Diseases （2024academic year） 1st semester  - 月4

  • Practica A for Clinical Specialties in Dentistry（Public Health Dentistry） （2024academic year） special  - その他

  • Practica A for Clinical Specialties in Dentistry（Clinical Preventive Dentistry） （2024academic year） special  - その他

  • Practica A for Clinical Specialties in Dentistry（Evidence Based Dentistry） （2024academic year） special  - その他

  • Practica B for Clinical Specialties in Dentistry（Public Health Dentistry） （2024academic year） special  - その他

  • Practica B for Clinical Specialties in Dentistry（Clinical Preventive Dentistry） （2024academic year） special  - その他

  • Practica B for Clinical Specialties in Dentistry（Evidence Based Dentistry） （2024academic year） special  - その他

  • Epidemiology （2024academic year） Second semester  - 水1,水2

  • Social Dentistry & Forensic Dentistry （2024academic year） Third semester  - 水4,水5

  • Clinical Preventive Dentistry （2024academic year） Second semester  - 月1,月2

  • Clinical training: Clinical Preventive Dentistry （2024academic year） special  - その他

  • Lecture and Research Projects: Clinical Preventive Dentistry （2024academic year） special  - その他

  • Clinical training: Evidence Based Dentistry （2024academic year） special  - その他

  • Lecture and Research Projects: Evidence Based Dentistry （2024academic year） special  - その他

  • Human Ecology （2023academic year） Fourth semester  - 火3

  • Health Statistics （2023academic year） Second semester  - 水3

  • Public Health （2023academic year） Fourth semester  - 火1,火2

  • Practice in Oral Health Evaluation （2023academic year） 1st semester  - 月5,月6,月7

  • Oral Health （2023academic year） Third semester  - 金2,金3

  • Dental Health （2023academic year） 1st and 2nd semester  - 金7～8

  • Etiology of Oral Diseases （2023academic year） 1st semester  - 月4

  • Epidemiology （2023academic year） Second semester  - 水1,水2

  • Social Dentistry & Forensic Dentistry （2023academic year） Third semester  - 水4,水5

  • Clinical Preventive Dentistry （2023academic year） Second semester  - 月1,月2

  • Human Ecology （2022academic year） Fourth semester  - 火3

  • Health Statistics （2022academic year） Second semester  - 水3

  • Public Health （2022academic year） Fourth semester  - 火1,火2

  • Practice in Oral Health Evaluation （2022academic year） 1st semester  - 月5,月6,月7

  • Oral Health （2022academic year） Third semester  - 金2,金3

  • Etiology of Oral Diseases （2022academic year） 1st semester  - 月4

  • Epidemiology （2022academic year） Second semester  - 水1,水2

  • Social Dentistry &？ Forensic Dentistry （2022academic year） Third semester  - 水4,水5

  • Clinical Preventive Dentistry （2022academic year） Second semester  - 月1,月2

  • Practice in Oral Health Evaluation （2021academic year） 1st semester  - 月5,月6,月7

  • Etiology of Oral Diseases （2021academic year） 1st semester  - 月4

  • Practice in Oral Health Evaluation （2020academic year） 1st semester  - 月5,月6,月7

  • Etiology of Oral Diseases （2020academic year） 1st semester  - 月4

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Media Coverage

  • 肥満になると歯周病悪化 Newspaper, magazine

    山陽新聞  2022.7.4

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    Author：Other 

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  • 歯周病 やはり肥満が大敵 動物実験でメカニズム解明 Newspaper, magazine

    朝日新聞  2022.5.28

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    Author：Other 

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