研究者詳細 - 三好　健太郎

論文 - 三好　健太郎

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気管支断端被覆の適応と方法局所進行非小細胞肺癌に対する術前化学放射線療法後肺切除術における気管支断端および吻合部被覆の検討

土生智大, 山本寛斉, 田中真, 諏澤憲, 枝園和彦, 三好健太郎, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

日本胸部外科学会定期学術集会 74回 LDB2 - 5 2021年10月

気管支断端被覆の適応と方法局所進行非小細胞肺癌に対する術前化学放射線療法後肺切除術における気管支断端および吻合部被覆の検討

土生智大, 山本寛斉, 田中真, 諏澤憲, 枝園和彦, 三好健太郎, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

日本胸部外科学会定期学術集会 74回 LDB2 - 5 2021年10月

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Locally Advanced Non-small-cell Lung Cancer Treated with Trimodality Therapy 査読国際誌

Shimpei Tsudaka, Hiromasa Yamamoto, Hiroki Sato, Kuniaki Katsui, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Katsuyuki Kiura, Susumu Kanazawa, Shinichi Toyooka

Annals of Surgical Oncology 28 ( 9 ) 4880 - 4890 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

PURPOSE: Current evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor in several types of cancer. In this study, we aimed to evaluate the prognostic impact of clinicopathological factors, including postoperative NLR, in patients with locally advanced non-small-cell lung cancer (LA-NSCLC) who underwent surgery after chemoradiotherapy (CRT) with or without postoperative adjuvant chemotherapy. METHODS: The medical records of LA-NSCLC patients treated with trimodality therapy at our institution between June 1999 and May 2019 were reviewed. The association between several clinicopathological factors and overall survival (OS) was analyzed. RESULTS: A total of 168 patients were included in this study. Regarding the prognosis, the 5-year OS rate was 68.1%, and the 2-year recurrence-free survival rate was 66.1% in the entire population. In multivariate analysis, we identified that high postoperative NLR, not pretreatment or preoperative NLR, was one of the independent factors for unfavorable OS (NLR high vs NLR low; hazard ratio = 2.45, 95% confidence interval: 1.53-3.94, p < 0.001). In addition, among patients with high postoperative NLR, patients who received postoperative adjuvant chemotherapy showed significantly better 5-year OS compared with those who did not (p = 0.016). On the other hand, postoperative adjuvant chemotherapy had no impact on the prognosis in patients with low NLR (p = 0.19). CONCLUSIONS: Our results suggest that high postoperative NLR was not only an independent unfavorable prognostic factor in patients with LA-NSCLC who were treated with trimodality therapy, but also a promising indicator for postoperative treatment in this population.

DOI： 10.1245/s10434-021-09690-9

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その他リンク： https://link.springer.com/article/10.1245/s10434-021-09690-9/fulltext.html

肺移植におけるドナー不足にどう取組むか心停止ドナー肺移植、スペインでの経験を踏まえて

田中真, 石上恵美, 石原恵, 富岡泰章, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

移植 56 ( 総会臨時 ) SSY9 - 4 2021年9月

肺移植に関連した感染症(待機中から術後慢性期まで) Clostridioides difficile感染症診療ガイドライン作成に伴う当院での肺移植周術期の検討

久保友次郎, 田中真, 石上恵美, 石原恵, 坂田龍平, 富岡泰章, 枝園和彦, 諏澤憲, 大谷真二, 山本寛斉, 三好健太郎, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

移植 56 ( 総会臨時 ) SSY4 - 4 2021年9月

肺移植におけるドナー不足にどう取組むか心停止ドナー肺移植、スペインでの経験を踏まえて

田中真, 石上恵美, 石原恵, 富岡泰章, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

移植 56 ( 総会臨時 ) SSY9 - 4 2021年9月

マウス異所性気管移植モデルを用いたS100A8/A9抗体の慢性移植肺機能不全に対する効果の検討

清水大, 岡崎幹生, 木下理恵, 中田憲太郎, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 阪口政清, 豊岡伸一

移植 56 ( 総会臨時 ) P2 - 11 2021年9月

肺移植に関連した感染症(待機中から術後慢性期まで) びまん性汎細気管支炎に対する肺移植後の慢性期管理と長期成績

杉本誠一郎, 三好健太郎, 田中真, 富岡泰章, 石原恵, 石上恵美, 諏澤憲, 枝園和彦, 山本寛斉, 岡崎幹生, 山根正修, 豊岡伸一

移植 56 ( 総会臨時 ) SSY4 - 5 2021年9月

肺移植に関連した感染症(待機中から術後慢性期まで) びまん性汎細気管支炎に対する肺移植後の慢性期管理と長期成績

杉本誠一郎, 三好健太郎, 田中真, 富岡泰章, 石原恵, 石上恵美, 諏澤憲, 枝園和彦, 山本寛斉, 岡崎幹生, 山根正修, 豊岡伸一

移植 56 ( 総会臨時 ) SSY4 - 5 2021年9月

肺移植における多職種連携新型コロナウイルス感染症(COVID-19)流行下での肺移植後患者フォローの工夫と課題

石原恵, 杉本誠一郎, 石上恵美, 鶴園真理, 山下里美, 難波由美子, 富岡泰章, 田中真, 三好健太郎, 大谷真二, 山根正修, 豊岡伸一

移植 56 ( 総会臨時 ) SWS3 - 2 2021年9月

肺移植に関連した感染症(待機中から術後慢性期まで) Clostridioides difficile感染症診療ガイドライン作成に伴う当院での肺移植周術期の検討

移植 56 ( 総会臨時 ) SSY4 - 4 2021年9月

生体肺移植後CLADにおける2019年ISHLT新基準にもとづく予後評価

松原慧, 三好健太郎, 大谷真二, 川名伸一, 久保友次郎, 清水大, 富岡泰章, 田中真, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

移植 56 ( 総会臨時 ) O23 - 1 2021年9月

肺移植後の慢性期合併症とその管理肺移植後の慢性腎臓病に対して血液透析を導入した症例の検討

富岡泰章, 杉本誠一郎, 川名伸一, 久保友次郎, 清水大, 松原慧, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 山根正, 豊岡伸一

移植 56 ( 総会臨時 ) SWS8 - 4 2021年9月

マウス異所性気管移植モデルを用いたS100A8/A9抗体の慢性移植肺機能不全に対する効果の検討

清水大, 岡崎幹生, 木下理恵, 中田憲太郎, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 阪口政清, 豊岡伸一

移植 56 ( 総会臨時 ) P2 - 11 2021年9月

Robot-assisted thoracoscopic lobectomy for severe incomplete interlober fissure 査読国際誌

Mikio Okazaki, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

Journal of Surgical Case Reports 2021 ( 8 ) rjab336 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

<title>Abstract</title>
An incomplete interlobar fissure makes thoracoscopic lobectomy difficult and is predictive of morbidity after thoracoscopic lobectomy. This report demonstrates the robot-assisted thoracoscopic (RATS) lobectomy technique for patients with severe incomplete interlobar fissures. A fissureless approach was chosen for pulmonary resection. Near-infrared fluorescence imaging with intravenous indocyanine green (ICG) was used to detect the interlobar line after transection of the bronchus, pulmonary artery and vein. Interlobar fissure was identified and divided by robotic staplers. This combined technique using ICG and fissureless lobectomy made RATS lobectomy safe for patients with severe incomplete interlobar fissures.

DOI： 10.1093/jscr/rjab336

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Emphysematous changes and lower levels of plasma irisin are associated with bronchiolitis obliterans syndrome after bilateral living-donor lobar lung transplantation 査読

Toshio Shiotani, Seiichiro Sugimoto, Haruchika Yamamoto, Kentaroh Miyoshi, Shinji Otani, Ken Suzawa, Hiromasa Yamamoto, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

Surgery Today 52 ( 2 ) 294 - 305 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

PURPOSE: Decreased irisin levels may be associated with the development of emphysema. Similarly, emphysematous changes may develop in patients with chronic lung allograft dysfunction (CLAD) after living-donor lobar lung transplantation (LDLLT). We investigated the severity of emphysematous changes and the relationship between irisin levels and CLAD after bilateral LDLLT and cadaveric lung transplantation (CLT). METHODS: The subjects of this retrospective study were 59 recipients of bilateral LDLLT (n = 31) or CLT (n = 28), divided into a non-CLAD group (n = 41), a LDLLT-CLAD group (n = 11), and a CLT-CLAD group (n = 7). We compared the severity of emphysematous changes, the skeletal muscle mass, and the plasma irisin levels among the groups. RESULTS: The emphysematous changes were significantly more severe in the LDLLT-CLAD and CLT-CLAD groups (p = 0.046 and 0.036), especially in patients with bronchiolitis obliterans syndrome (BOS), than in the non-CLAD group. Although the skeletal muscle mass was similar in all the groups, the plasma irisin levels were significantly lower in the LDLLT-CLAD group (p = 0.022), especially in the patients with BOS after LDLLT, than in the non-CLAD group. CONCLUSION: Emphysematous changes and lower levels of plasma irisin were associated with CLAD, especially in patients with BOS, after bilateral LDLLT.

DOI： 10.1007/s00595-021-02339-w

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その他リンク： https://link.springer.com/article/10.1007/s00595-021-02339-w/fulltext.html

“Hybrid Lung Transplantation” Combining Living Donor and Cadaveric Lung Transplants: Report of 2 Cases 査読

Takeshi Kurosaki, Takahiro Oto, Shinji Otani, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

Transplantation Proceedings 53 ( 6 ) 2004 - 2007 2021年7月

Lung transplantation for bronchiectasis due to hyper-immunoglobulin E syndrome 査読国際誌

Dai Shimizu, Shinji Otani, Seiichiro Sugimoto, Haruchika Yamamoto, Yasuaki Tomioka, Toshio Shiotani, Kentaroh Miyoshi, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

The Annals of Thoracic Surgery 113 ( 4 ) e251-e253 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

Hyperimmunoglobulin E syndrome (HIES) is one of the primary immunodeficiencies characterized by recurrent staphylococcal skin and lung infections that result in lung destruction and critically diminished pulmonary function. Despite the lack of definitive treatment, there have been no reports of successful lung transplantation for HIES patients. We report the case of a 42-year-old woman with HIES with progressive bronchiectasis whose pulmonary infection was controlled before transplantation, and subsequent lung transplantation was uneventful. Lung transplantation may be feasible in HIES if the patient is immunologically stable preoperatively and perioperative infections, especially Aspergillus infections, are well controlled.

DOI： 10.1016/j.athoracsur.2021.05.088

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The prognostic impact of sarcopenia on elderly patients undergoing pulmonary resection for non-small cell lung cancer 査読

Akihiro Miura, Hiromasa Yamamoto, Hiroki Sato, Yasuaki Tomioka, Toshio Shiotani, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

Surgery Today 51 ( 7 ) 1203 - 1211 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

PURPOSE: The number of elderly patients who undergo surgery is increasing, even though they are at a high risk due to a decreased physical strength. Furthermore, sarcopenia is generally associated with a poor prognosis in patients with non-small cell lung cancer (NSCLC). METHODS: This study included NSCLC patients ≥ 65 years old who underwent pulmonary resection in our hospital between 2012 and 2015. Sarcopenia was assessed using the psoas muscle mass index based on computed tomography at the level of the third lumbar vertebra. We elucidated the impact of sarcopenia on short- and long-term outcomes after surgery. RESULTS: We enrolled 259 patients, including 179 with sarcopenia. Patients with sarcopenia before surgery tended to have postoperative complications (p = 0.0521), although they did not show a poor prognosis. In patients with sarcopenia, a multivariate analysis revealed that postoperative complications and the progression of sarcopenia 1 year after surgery were significant risk factors for a poor prognosis (p = 0.0169 and 0.00370, respectively). CONCLUSIONS: The progression of sarcopenia after surgery is associated with a poor prognosis in elderly NSCLC patients with sarcopenia. A strategy to prevent postoperative progressive sarcopenia may be necessary for improving the clinical outcome of this population.

DOI： 10.1007/s00595-020-02221-1

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その他リンク： https://link.springer.com/article/10.1007/s00595-020-02221-1/fulltext.html

シャント造設を契機に片側肺の肺水腫及び肺高血圧を来した両側生体肺移植後CLADの一例

清水大, 三好健太郎, 東馬智子, 松田裕介, 松原慧, 富岡泰章, 塩谷俊雄, 山本治慎, 大谷真二, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

移植 56 ( 1 ) 104 - 104 2021年7月

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