Updated on 2025/12/22

写真a

 
Sakura Takanobu
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
External link

Degree

  • Doctor of Philosophy ( 2025.3   Okayama University )

Research Interests

  • pediatric cardiac anesthesia

 

Papers

  • Association of carboxyhemoglobin and methemoglobin levels with hemolysis during extracorporeal membrane oxygenation. International journal

    Tsubasa Yoshida, Satoshi Kimura, Takanobu Sakura, Tatsuhiko Shimizu, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Tatsuo Iwasaki, Hiroshi Morimatsu

    The International journal of artificial organs   48 ( 4 )   250 - 257   2025.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Hemolysis, characterized by increased carboxyhemoglobin (COHb) and methemoglobin (MetHb) levels, is a complication of extracorporeal membrane oxygenation (ECMO). METHODS: This prospective single-center study aimed to investigate the correlation between COHb and MetHb levels and hemolysis during ECMO. This study included 32 patients requiring ECMO for circulatory or respiratory failure. Plasma-free hemoglobin (pfHb), COHb, and MetHb levels were measured simultaneously within 6 h of ECMO induction, daily during ECMO, within 6 h after decannulation, and 2 days after decannulation unless death occurred before. Patients were classified into hemolysis and non-hemolysis groups based on whether the maximum pfHb level during ECMO was ⩾50 mg/dL. RESULTS: No significant difference in maximum COHb levels during ECMO (COHbECMO) was observed between the hemolysis and non-hemolysis groups (2.15% [interquartile range (IQR) = 1.83, 2.60] vs 1.65% [IQR = 1.40, 2.10], p = 0.159). However, maximum MetHb levels during ECMO (MetHbECMO) were significantly higher in the hemolysis group (1.35% [IQR = 1.12, 1.78] vs 1.10% [IQR = 0.90, 1.37], p = 0.045). The Spearman's correlation coefficients for COHbECMO and MetHbECMO were 0.39 (95% confidence interval [CI] = 0.456-0.649) and 0.66 (95% CI = 0.404-0.820), respectively. CONCLUSION: Elevated MetHb levels in patients undergoing ECMO may be associated with hemolysis.

    DOI： 10.1177/03913988251326398

    PubMed

    researchmap

  • Association between plasma-free haemoglobin and postoperative acute kidney injury in paediatric cardiac surgery: a prospective observational study Reviewed

    Takanobu Sakura, Tomoyuki Kanazawa, Tatsuhiko Shimizu, Kazuyoshi Shimizu, Tatsuo Iwasaki, Hiroshi Morimatsu

    BJA Open   12   100348 - 100348   2024.12

    　More details

    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bjao.2024.100348

    researchmap

  • A Retrospective Comparative Study of the Frequency of Hypotension in Pediatric Cardiac Catheterization under General Anesthesia: Remimazolam versus Sevoflurane. International journal

    Tatsuhiko Shimizu, Tomoyuki Kanazawa, Tsubasa Yoshida, Takanobu Sakura, Kazuyoshi Shimizu, Tatsuo Iwasaki, Hiroshi Morimatsu

    Journal of cardiothoracic and vascular anesthesia   2024.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: To compare the incidence of hypotension between remimazolam and sevoflurane under general anesthesia for cardiac catheterization in patients with congenital heart disease. DESIGN: Retrospective observational study. SETTING: A single university hospital with 300 pediatric cardiac catheterizations by general anesthesia performed annually. PARTICIPANTS: Patients younger than 15 years who underwent cardiac catheterization under general anesthesia between March 1, 2021, and December 31, 2022. Exclusion criteria were general anesthesia maintained with other than remimazolam or sevoflurane, receipt of remifentanil, American Society of Anesthesiologists score 4 or 5, emergency procedures, and no direct arterial pressure measurement. INTERVENTIONS: General anesthesia was maintained with remimazolam or sevoflurane. MEASUREMENTS AND MAIN RESULTS: A total of 309 patients were analyzed, including 28 in the remimazolam group and 281 in the sevoflurane group. Propensity score matching adjusted for confounding factors resulted in 28 patients in each arm, with no apparent differences in background factors. Hypotension was defined as a time-averaged area > 1, in which systolic arterial pressure fell below 80% of the baseline from the start of anesthesia to the end of procedure. The significance level was set at P < .05. The incidence of hypotension was 39.3% in the remimazolam arm and 46.4% in the sevoflurane arm, with no significant difference (P = .79), although the ratio of the median systolic arterial pressure to the baseline value was significantly higher in the remimazolam arm (91.4 ± 15.2% vs 83.2 ± 11.4% in the sevoflurane arm; P = .03). CONCLUSIONS: Remimazolam was not associated with a lower incidence of hypotension compared to sevoflurane during pediatric cardiac catheterization for congenital heart disease while maintaining significantly higher blood pressure overall.

    DOI： 10.1053/j.jvca.2024.08.038

    PubMed

    researchmap

  • 高齢の右室二腔症患者にロボット支援下膵頭十二指腸切除を施行した1症例

    加藤 光晴, 佐倉 考信, 片山 明, 清水 達彦, 岩崎 達雄

    Cardiovascular Anesthesia   28 ( Suppl. )   301 - 301   2024.9

    　More details

    Language：Japanese   Publisher：(一社)日本心臓血管麻酔学会  

    researchmap

  • General Anesthesia With Remimazolam During Minimally Invasive Cardiac Surgery for Atrial Septal Defect: A Pediatric Case Report. International journal

    Tatsuhiko Shimizu, Tomoyuki Kanazawa, Yuto Matsuoka, Tsubasa Yoshida, Takanobu Sakura, Kazuyoshi Shimizu, Tatsuo Iwasaki, Hiroshi Morimatsu

    A&A practice   18 ( 1 )   e01735   2024.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Remimazolam is a new ultrashort-acting benzodiazepine sedative, the use of which has not been reported for pediatric cardiac surgery. This case report describes the use of remimazolam in a 6-year-old girl who underwent minimally invasive cardiac surgery with right-sided thoracotomy for an atrial septal defect. Under electroencephalographic monitoring, remimazolam (2-4 mg kg-1 h-1) and remifentanil (0.05 μg kg-1 min-1) were administered with an intercostal nerve block during the procedure. The patient awoke and was extubated promptly after surgery, without any serious adverse events, including intraoperative awareness. Remimazolam may be a viable option for general anesthesia during pediatric cardiac surgery.

    DOI： 10.1213/XAA.0000000000001735

    PubMed

    researchmap

  • Carboxyhemoglobin and Methemoglobin Levels and Hemolysis in Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass. International journal

    Tsubasa Yoshida, Takanobu Sakura, Kazuyoshi Shimizu, Satoshi Kimura, Tatsuo Iwasaki, Tomoyuki Kanazawa, Hiroshi Morimatsu

    ASAIO journal (American Society for Artificial Internal Organs : 1992)   2023.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Hemolysis is a complication of cardiopulmonary bypass (CPB). Carboxyhemoglobin (COHb) and methemoglobin (MetHb) were suggested as potential hemolysis biomarkers. This retrospective study was based on a prospective registry aimed to determine the association of COHb and MetHb levels with hemolysis in pediatric patients <4 years old who underwent cardiac surgery with CPB. Plasma-free hemoglobin (PFH), COHb, and MetHb levels were measured before CPB; every 30 minutes during CPB; and on postoperative days 1, 2, and 3. Patients were classified into hemolysis and nonhemolysis groups based on the maximum PFH levels during CPB. A total of 193 patients were included. No significant difference was observed in the maximum COHb levels during CPB (COHbCPB) between the hemolysis and nonhemolysis groups (1.2% [interquartile range {IQR} 0.9-1.4%] vs. 1.1% [IQR: 0.9-1.4%]; p = 0.17). The maximum MetHb levels during CPB (MetHbCPB) were significantly higher in the hemolysis group than in the nonhemolysis group (1.3% [IQR: 1.1-1.5%] vs. 1.2% [IQR: 1.0-1.4%]; p = 0.007). Areas under the receiver operating curves of COHbCPB and MetHbCPB were 0.557 (95% confidence interval: 0.475-0.640) and 0.615 (95% confidence interval: 0.535-0.695), respectively. Therefore, the predictive ability of both hemolysis biomarkers during CPB is limited.

    DOI： 10.1097/MAT.0000000000002044

    PubMed

    researchmap

  • 全身麻酔下小児心臓カテーテルにおける低血圧発生率:レミマゾラムとセボフルランの後方視的比較検討

    清水 達彦, 金澤 伴幸, 吉田 翼, 佐倉 考信, 清水 一好, 岩崎 達雄, 森松 博史

    日本小児麻酔学会誌   29 ( Suppl. )   113 - 113   2023.10

    　More details

    Language：Japanese   Publisher：(一社)日本小児麻酔学会  

    researchmap

  • 食道閉鎖根治術後の食道右上葉肺瘻に対して2本のFogarty catheterで分離肺換気を行った一例

    吉田 翼, 金澤 伴幸, 佐倉 考信, 清水 達彦, 清水 一好, 岩崎 達雄

    日本小児麻酔学会誌   29 ( Suppl. )   178 - 178   2023.10

    　More details

    Language：Japanese   Publisher：(一社)日本小児麻酔学会  

    researchmap

  • 全身麻酔下小児心臓カテーテルにおける低血圧発生率:レミマゾラムとセボフルランの後方視的比較検討

    清水 達彦, 金澤 伴幸, 吉田 翼, 佐倉 考信, 清水 一好, 岩崎 達雄, 森松 博史

    日本小児麻酔学会誌   29 ( Suppl. )   113 - 113   2023.10

    　More details

    Language：Japanese   Publisher：(一社)日本小児麻酔学会  

    researchmap

  • 食道閉鎖根治術後の食道右上葉肺瘻に対して2本のFogarty catheterで分離肺換気を行った一例

    吉田 翼, 金澤 伴幸, 佐倉 考信, 清水 達彦, 清水 一好, 岩崎 達雄

    日本小児麻酔学会誌   29 ( Suppl. )   178 - 178   2023.10

    　More details

    Language：Japanese   Publisher：(一社)日本小児麻酔学会  

    researchmap

  • フォンタン手術後の肝切除術の麻酔経験

    道満 啓, 佐倉 考信, 藤井 彩加, 松崎 孝, 岩崎 達雄, 森松 博史

    麻酔   72 ( 8 )   769 - 773   2023.8

    　More details

  • Efficacy of prophylactic high-flow nasal cannula therapy for postoperative pulmonary complications after pediatric cardiac surgery: a prospective single-arm study.

    Tatsuhiko Shimizu, Tomoyuki Kanazawa, Takanobu Sakura, Naohiro Shioji, Kazuyoshi Shimizu, Ryuichiro Fukuhara, Takayoshi Shinya, Tatsuo Iwasaki, Hiroshi Morimatsu

    Journal of anesthesia   37 ( 3 )   433 - 441   2023.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: This study investigated the incidence of postoperative pulmonary complications (PPC) when high-flow nasal cannula therapy (HFNC) is used prophylactically after pediatric cardiac surgery, and evaluated its efficacy. METHODS: This was a single-arm prospective interventional study that was conducted in a tertiary teaching hospital with eight beds in the pediatric cardiac ICU after approval by the Ethics Committee. One-hundred children under the age of 48 months who were scheduled for cardiac surgery for congenital heart disease were recruited. HFNC was used for 24 h after extubation at a 2 L/kg/min flow rate. The primary outcome was the incidence of PPC within 48 h after extubation. PPC was defined as atelectasis and acute respiratory failure meeting certain criteria. We considered prophylactic HFNC as effective if the prevalence of PPC was < 10%, based on previous reports of reintubation rates of 6%-9% after pediatric cardiac surgery. RESULTS: A total of 91 patients were finally included in the analysis. The incidence of PPC within 48 h after extubation was 18.7%, whereas atelectasis was observed in 13.2%, and acute respiratory failure in 8.8%. Reintubation rate within 48 h after extubation was 0%. CONCLUSIONS: We found the incidence of PPC with prophylactic HFNC after planned extubation after pediatric cardiac surgery. However, the incidence was > 10%; therefore, we could not demonstrate its efficacy in this single-arm study. Further studies are needed to investigate whether the HFNC could be adapted as first-line oxygen therapy after pediatric cardiac surgery.

    DOI： 10.1007/s00540-023-03187-3

    PubMed

    researchmap

  • 小児の全身麻酔下におけるPatient State indexと呼気終末セボフルラン濃度の関連性 単施設後ろ向き研究

    清水 達彦, 金澤 伴幸, 吉田 翼, 佐倉 考信, 木村 聡, 清水 一好, 岩崎 達雄, 森松 博史

    日本小児麻酔学会誌   27 ( Suppl. )   172 - 172   2022.10

    　More details

    Language：Japanese   Publisher：(一社)日本小児麻酔学会  

    researchmap

  • インヒビター保有血友病A患者に対する肝切除術後に出血を来した1症例

    佐藤 航貴, 松崎 孝, 佐倉 考信, 森松 博史

    麻酔   71 ( 6 )   623 - 626   2022.6

    　More details

  • Intact survival from severe cardiogenic shock caused by the first attack of atrial tachycardia treated with extracorporeal membrane oxygenation and surgical left atrium appendage resection: a case report. International journal

    Tatsuhiko Shimizu, Tomoyuki Kanazawa, Takanobu Sakura, Kazuyoshi Shimizu, Tatsuo Iwasaki

    JA clinical reports   7 ( 1 )   81 - 81   2021.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Atrial tachycardia (AT) is rare in children and can usually be reversed to sinus rhythm with pharmacotherapy and cardioversion. We report a rare case of severe left-sided heart failure due to refractory AT. CASE PRESENTATION: A 12-year-old boy had AT with a heart rate of 180 beats/minute, which was refractory to any medication and defibrillation despite the first attack. Due to rapid cardiorespiratory collapse shortly after arriving at our hospital, central extracorporeal membrane oxygenation (ECMO) with left arterial venting was started immediately. Although AT persisted after that, it stopped on the 3rd day after admission following surgical resection of the left atrial appendage thought to be the source of AT. He was weaned off ECMO on the 7th day and ventilator on the 14th day. CONCLUSIONS: The appropriate timing of central ECMO and surgical ablation were effective in saving this child from a life-threatening situation caused by refractory AT.

    DOI： 10.1186/s40981-021-00481-5

    PubMed

    researchmap

  • 高トリグリセリド血症起因性急性膵炎にLDL(low density lipoprotein)吸着療法が奏功した妊婦の1例

    佐倉 考信, 清水 一好, 廣井 一正, 鈴木 聡, 林 真雄, 賀来 隆治, 森松 博史

    日本集中治療医学会雑誌   24 ( 1 )   26 - 30   2017.1

    　More details

    Language：Japanese   Publisher：(一社)日本集中治療医学会  

    researchmap

▼display all

Books

  • 小児の疼痛管理

    佐倉考信, 岩崎達雄（ Role： Joint author ,  検査・処置での鎮痛・鎮静）

    克誠堂出版  2025.10 

    　More details

  • LiSA

    佐倉考信, 岩崎達雄（ Role： Joint author ,  徹底分析シリーズ 吸入麻酔と静脈麻酔どっちを選ぶ？ 人工心肺を用いる心臓手術）

    メディカル・サイエンス・インターナショナル  2025.4 

    　More details

  • LiSA

    佐倉考信（ Role： Joint author ,  奨励カンファレンス 胸郭低形成患者の呼吸管理 PLAN 3 一期的根治術として肺血流を増やさない管理を心がける）

    メディカル・サイエンス・インターナショナル  2025.1 

    　More details

  • 気道管理大全

    佐倉考信, 片山明, 森松博史（ Role： Joint author ,  シングルルーメンチューブ）

    真興交易株式会社医書出版部  2024.6 

    　More details

MISC

▼display all

 

Class subject in charge

  • Anesthesiology and Resuscitology (Core Clinical Practice) （2025academic year） special  - その他

  • Anesthesiology and Resuscitology （2025academic year） special  - その他

  • Anesthesiology and Resuscitology （2024academic year） special  - その他