Faculty Profiles - YANAI Hiroyuki

MISC - YANAI Hiroyuki

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脳腫瘍の分子診断と治療2 NF1関連グリオーマにおける腫瘍微小環境の解析

駿河和城, 大谷理浩, 松本悠司, 平野秀一郎, 藤井謙太郎, 石田穣治, 柳井広之, 田中將太

Brain Tumor Pathology 41 ( Suppl. ) 100 - 100 2024.5

Endoscopic and Histological Gastritis in University Students with Helicobacter pylori Infection.

Shotaro Okanoue, Hiroyuki Sakae, Kenji Yokota, Takehiro Tanaka, Yuka Obayashi, Makoto Abe, Yoshiyasu Kono, Hiromitsu Kanzaki, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Yanai, Hiroyuki Okada

Internal medicine (Tokyo, Japan) 2024.3

Language：English

Objective Although the characteristics of Helicobacter pylori infection have been extensively reported, there is a lack of consensus regarding its characteristics in young adults. The present study examined the endoscopic and histological characteristics of young adults who underwent eradication therapy for H. pylori infection. Methods We examined the H. pylori infection status of first-year students at Okayama University School of Medicine and Dentistry between 2014 and 2020. A total of 152 (6.8%) students who were positive for H. pylori antibody or pepsinogen tests were enrolled in the study. Among them, 107 students underwent endoscopy, and their biopsy samples were investigated. Seventy-five students were diagnosed with H. pylori infections. Results Of 75 H. pylori-positive patients, 57 (76.0%) had endoscopic atrophic gastritis, and 42 (56.0%) had histological atrophy. A few patients had severe atrophic gastritis. All 65 patients who underwent an eradication assessment were successfully treated. After successful eradication, 26 patients underwent endoscopic follow-up. The mean follow-up period was 32.9 months. A histological evaluation revealed that gastric antrum atrophy had subsided in 11 of 14 patients, and atrophy in the lesser curvature of the gastric body had subsided in 7 of 8 patients. Conclusion More than half of young adults with H. pylori infection had atrophic gastritis. We found mild atrophy in young adults, which subsided shortly after eradication treatment. This study provides a foundation for future studies to evaluate the validity of eradication therapy in preventing gastric cancer in patients.

DOI： 10.2169/internalmedicine.1851-23

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耳下腺に発生したCarcinoma showing thymus-like differentiation(CASTLE)の一例

小野早和子, 西田賢司, 柳井広之, 井川卓朗, 田中健大, 山元英崇

日本病理学会会誌 113 ( 1 ) 346 - 346 2024.2

Analysis of the tumor microenvironment in NF1-related gliomas

駿河和城, 大谷理浩, 松本悠司, 石田穣治, 井上陽平, 平野秀一郎, 藤井謙太郎, 柳井広之, 山本英喜, 里見介史, 市村幸一, 平戸純子, 田中將太

小児の脳神経(Web) 49 ( 2 ) 2024

唾液腺分泌癌の細胞病理学的所見とギムザ染色の診断的有用性

植田向夏花, 錦織歩, 江草侑厘安, 錦織亜沙美, 西村碧フィリーズ, 柳井広之, 佐藤康晴

岡山県臨床細胞学会誌 41 43 - 43 2023.12

Advances in treatment of alveolar soft part sarcoma: an updated review. International journal

Tomohiro Fujiwara, Toshiyuki Kunisada, Eiji Nakata, Kenji Nishida, Hiroyuki Yanai, Tomoki Nakamura, Kazuhiro Tanaka, Toshifumi Ozaki

Japanese journal of clinical oncology 2023.8

Language：English

Alveolar soft part sarcoma is a rare neoplasm of uncertain histogenesis that belongs to a newly defined category of ultra-rare sarcomas. The neoplasm is characterized by a specific chromosomal translocation, der (17) t(X; 17)(p11.2;q25), that results in ASPSCR1-TFE3 gene fusion. The natural history of alveolar soft part sarcoma describes indolent behaviour with slow progression in deep soft tissues of the extremities, trunk and head/neck in adolescents and young adults. A high rate of detection of distant metastasis at presentation has been reported, and the most common metastatic sites in decreasing order of frequency are the lung, bone and brain. Complete surgical resection remains the standard treatment strategy, whereas radiotherapy is indicated for patients with inadequate surgical margins or unresectable tumours. Although alveolar soft part sarcoma is refractory to conventional doxorubicin-based chemotherapy, monotherapy or combination therapy using tyrosine kinase inhibitors and immune checkpoint inhibitors have provided antitumor activity and emerged as new treatment strategies. This article provides an overview of the current understanding of this ultra-rare sarcoma and recent advancements in treatments according to the clinical stage of alveolar soft part sarcoma.

DOI： 10.1093/jjco/hyad102

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血流豊富な粘膜下腫瘍の形態を呈した上行結腸血管周囲類上皮細胞腫の1例

青山祐樹, 井口俊博, 平岡佐規子, 豊澤惇希, 竹井健介, 井川翔子, 山崎泰史, 衣笠秀明, 高原政宏, 庄司良平, 近藤喜太, 柳井広之, 大塚基之

日本消化器内視鏡学会中国支部例会 130回 81 - 81 2023.6

脳腫瘍のメチル化診断診断困難症例に対するゲノムワイドメチル化解析の検討

大谷理浩, 藤井謙太郎, 石田穣治, 駿河和城, 鷲尾佳奈, 柳井広之, 里見介史, 市村幸一, 伊達勲

Brain Tumor Pathology 40 ( Suppl. ) 062 - 062 2023.5

がんゲノム医療がもたらす小児脳腫瘍の展開当院における小児グリオーマ診療についてがんゲノム医療時代における変遷

石田穣治, 大谷理浩, 藤井謙太郎, 佐々木達也, 鷲尾佳奈, 柳井広之, 遠西大輔, 山本英喜, 伊達勲

小児の脳神経 48 ( 2 ) 153 - 153 2023.4

老年学的因子は浸潤性軟部肉腫患者の生存予後と相関するか

畑利彰, 藤原智洋, 柳井広之, 吉田晶, 板野拓人, 近藤彩奈, 片山晴喜, 佐藤浩平, 中田英二, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 97 ( 2 ) S80 - S80 2023.3

Two cases of early diagnosis of medullary thyroid carcinoma by genetic risk management for RET pathogenic germline variants

加藤芙美乃, 山本英喜, 山本英喜, 十川麗美, 二川摩周, 浦川優作, 植野さやか, 稲垣兼一, 柳井広之, 平沢晃, 平沢晃

日本遺伝カウンセリング学会誌 44 ( 2 ) 2023

リンチ症候群の医学的管理とユニバーサルスクリーニングに向けた諸課題の整理~当院でのリンチ症候群に関する診療科横断的会議から~

山本英喜, 山本英喜, 柳井広之, 柳井広之, 重安邦俊, 重安邦俊, 原賀順子, 原賀順子, 小川千加子, 小川千加子, 片山聡, 片山聡, 山崎泰史, 山崎泰史, 大里俊樹, 大里俊樹, 井上博文, 井上博文, 二川摩周, 二川摩周, 加藤芙美乃, 十川麗美, 植野さやか, 植野さやか, 浦川優作, 浦川優作, 浦川優作, 藤原俊義, 藤原俊義, 増山寿, 増山寿, 荒木元朗, 荒木元朗, 大塚基之, 大塚基之, 平沢晃, 平沢晃

日本遺伝性腫瘍学会学術集会プログラム・抄録集 29th 2023

ペムブロリズマブ投与後IFNβ局注,イミキモド外用を併用した悪性黒色腫in-transit転移の1例

山崎修, 杉原悟, 立花宏太, 三宅智子, 森実真, 柳井広之, 荒川謙三

西日本皮膚科 84 ( 6 ) 570 - 571 2022.12

対側リスク低減乳房切除術で非浸潤性乳管癌が発見された遺伝性乳癌卵巣癌症候群の1例

中川里沙子, 宇野摩耶, 間森智加, 河内麻里子, 大谷悠介, 吉岡遼, 藤原みわ, 中本翔伍, 鈴木陽子, 安部優子, 鳩野みなみ, 高橋侑子, 都地友紘, 岩本高行, 枝園忠彦, 平成人, 柳井広之, 土井原博義

日本乳癌学会総会プログラム抄録集 30回 EP11 - 68 2022.6

小児脳腫瘍に対する新規治療がんゲノム医療時代における小児グリオーマ診療について

石田穣治, 藤井謙太郎, 大谷理浩, 坪井伸成, 畝田篤仁, 鷲尾佳奈, 柳井広之, 遠西大輔, 山本英喜

小児の脳神経 47 ( 2 ) 162 - 162 2022.4

Diagnosis and treatment for pediatric gliomas in the era of cancer genomic precision medicine in Okayama University Hospital

石田穣治, 藤井謙太郎, 大谷理浩, 坪井伸成, 畝田篤仁, 鷲尾佳奈, 柳井広之, 遠西大輔, 山本英喜

小児の脳神経(Web) 47 ( 2 ) 2022

尿細胞診によるBKウイルス腎症の発症予測は尿沈渣で代替可能か

関戸崇了, 荒木元朗, 吉永香澄, 山野井友昭, 丸山雄樹, 定平卓也, 西村慎吾, 枝村康平, 小林泰之, 田邊克幸, 竹内英実, 森永裕士, 和田淳, 柳井広之

日本移植学会総会プログラム抄録集 58th (Web) 2022

RAS/BRAF解析においてPCR-rSSO法とNGS法の併用による補完性が示された大腸癌の二例

山本英喜, 重安邦俊, 柳井広之, 井上博文, 井上博文, 松岡博美, 松岡博美, 青江伯規, 東影明人, 藤井敬子, 藤井敬子, 大塚文男, 大塚文男, 草野展周, 平沢晃

日本臨床検査医学会誌 70 2022

【悪性腫瘍と誤りやすい疾患】婦人科領域 Invited

柳井広之

病理と臨床 39 ( 3 ) 263 - 268 2021.3

Retroperitoneal malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1: A case report

Daijiro Soda, Takehiro Iwata, Takuya Sadahira, Yusuke Tominaga, Satoshi Katayama, Shingo Nishimura, Atsushi Takamoto, Tomoko Sako, Kohei Edamura, Yasuyuki Kobayashi, Motoo Araki, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu, Eiji Nakada, Hiroyuki Yanai

Nishinihon Journal of Urology 82 ( 86 ) 596 - 600 2021.2

Language：Japanese Publishing type：Book review, literature introduction, etc. Publisher：The West Japan Urological Association

A female patient in her thirties was diagnosed with neurofibroma by left axillary skin biopsy, and neurofibromatosis type 1 (NF-1
von Recklinghausen disease) was suspected based on characteristic skin findings (cafe-au-lait spots) and her family history. In February X, the patient consulted a doctor for right thigh and back pain. An MRI and contrast CT showed a 13 cm retroperitoneal tumor, which was suspected to have originated from the L2 nerve root and to have invaded the spinal canal. The doctor referred the patient to our department for a surgical procedure. We consulted the Department of Orthopaedic Surgery and performed an MRI-guided biopsy, which suggested the possibility of a malignant peripheral nerve sheath tumor (MPNST). In June X, we resected the right retroperitoneal tumor following arterial embolization. Pathological results confirmed it to be an MPNST. The patient has not experienced any recurrence during the 10 months since the surgery. MPNSTs are extremely rare tumors and there is no standard treatment for them because of their rarity. We experienced a case of retroperitoneal MPNST and we herein report the features of this case and present some review of the literature.

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