2021/04/25 更新

写真a

ヤナイ ヒロユキ
柳井 広之
YANAI Hiroyuki
所属
岡山大学病院 教授
職名
教授
外部リンク

学位

  • 医学博士 ( 岡山大学 )

研究キーワード

  • 婦人科病理

  • 泌尿器病理

  • Urologic Paghology

  • Gynecological Pathology

研究分野

  • ライフサイエンス / 人体病理学

学歴

  • 岡山大学   Graduate School of Medicine   Pathology

    1991年4月 - 1996年3月

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    国名: 日本国

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  • 岡山大学   医学部   医学科

    1985年4月 - 1991年3月

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    国名: 日本国

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経歴

  • 岡山大学   病理診断科   教授

    2011年5月 - 現在

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  • 岡山大学岡山大学病院   病理診断科   准教授

    2004年7月 - 2011年4月

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  • 岡山大学岡山大学病院   病理部   助手

    2004年1月 - 2004年6月

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所属学協会

▼全件表示

委員歴

  • 日本病理学会   小児腫瘍組織分類小委員会委員  

    2018年 - 現在   

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    団体区分:学協会

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  • 日本婦人科腫瘍学会   学術委員  

    2016年7月 - 現在   

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    団体区分:学協会

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  • 日本病理学会   剖検・病理技術委員会  

    2011年4月 - 2018年3月   

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    団体区分:学協会

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  • 日本婦人科病理学会   編集委員  

    2011年 - 現在   

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    団体区分:学協会

    日本婦人科病理学会

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論文

  • Fibrosis or Necrosis in Resected Lymph Node Indicate Metastasis Before Chemoradiotherapy in Lung Cancer Patients. 査読 国際誌

    Yuta Takahashi, Junichi Soh, Kazuhiko Shien, Hiromasa Yamamoto, Masaomi Yamane, Katsuyuki Kiura, Susumu Kanazawa, Hiroyuki Yanai, Shinichi Toyooka

    Anticancer research40 ( 8 ) 4419 - 4423   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/AIM: The histological features of lymph nodes (LNs) treated by chemoradiotherapy (CRT) in non-small cell lung cancer (NSCLC) have not been well studied. The purpose of this study was to evaluate the histological findings of LNs affected by CRT. PATIENTS AND METHODS: Among 107 clinically N2 NSCLC patients who underwent induction CRT followed by surgery from 1999 to 2017, 24 patients who received pathological evaluation of mediastinal LN before CRT were enrolled in this study. Postoperatively, we histologically reviewed all resected LNs (n=117) of the station evaluated before CRT. RESULTS: Fibrosis and/or necrosis were observed in all investigated LN stations. Histological observation of fibrosis and/or necrosis in the resected LNs after CRT indicated the presence of LN metastasis before CRT. CONCLUSION: The metastatic LNs that responded to CRT showed specific histological features, which enabled us to know the accurate clinical stage of the patient even though cancer cells were not found in the post-treated LNs.

    DOI: 10.21873/anticanres.14447

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  • Intracranial Mesenchymal Chondrosarcoma Lacking the Typical Histopathological Features Diagnosed by HEY1-NCOA2 Gene Fusion. 査読

    Atsuhito Uneda, Kazuhiko Kurozumi, Atsushi Fujimura, Atsunori Kamiya, Takanori Hirose, Hiroyuki Yanai, Isao Date

    NMC case report journal7 ( 2 ) 47 - 52   2020年4月

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    記述言語:英語  

    Intracranial mesenchymal chondrosarcoma (MCS) is a rare neoplasm. The diagnosis of MCS is confirmed by the presence of a biphasic pattern on histological examination, comprising undifferentiated small round cells admixed with islands of well-differentiated hyaline cartilage; however, a differential diagnosis may be challenging in some cases. A 28-year-old woman with a 2-month history of headache was referred to our hospital. Radiologic studies showed an extra-axial lobulated mass composed of calcified and uncalcified areas occupying the left middle fossa. Surgical resection was planned, but her headache suddenly worsened before her planned hospital admission and she was admitted as an emergency. Radiologic studies showed an acute hemorrhage in the uncalcified part of the mass. The mass was resected via the left zygomatic approach after embolization of the feeder vessels. The most likely histopathological diagnosis was MCS. However, the typical bimorphic pattern was not identified in our surgical samples; each undifferentiated area and well-differentiated area was observed separately in different tissue specimens, and no islands of well-differentiated hyaline cartilage were identified within the undifferentiated areas in the same specimen. Molecular assays confirmed the presence of HEY1-NCOA2 fusion. IRF2BP2-CDX1 fusion and IDH1/2 mutations were negative. The final diagnosis of MCS was made based on the presence of HEY1-NCOA2 gene fusion. MCS should be included in the differential diagnosis when radiologic studies show an extra-axial lobulated mass with calcification. Furthermore, molecular demonstration of HEY1-NCOA2 gene fusion may help make a precise diagnosis of MCS, especially in surgical samples lacking the typical histopathological features.

    DOI: 10.2176/nmccrj.cr.2019-0123

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  • Factors predicting pathological upgrading after prostatectomy in patients with Gleason grade group 1 prostate cancer based on opinion-matched biopsy specimens. 査読 国際誌

    Yuki Maruyama, Takuya Sadahira, Motoo Araki, Yosuke Mitsui, Koichiro Wada, Acosta Gonzalez Herik Rodrigo, Kazuaki Munetomo, Yasuyuki Kobayashi, Masami Watanabe, Hiroyuki Yanai, Toyohiko Watanabe, Yasutomo Nasu

    Molecular and clinical oncology12 ( 4 ) 384 - 389   2020年4月

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    記述言語:英語  

    The present study investigated the concordance between Gleason scores assigned to prostate biopsy specimens by outside pathologists and a urological pathology expert, and determined the risk of upgrading between opinion-matched Gleason grade group (GGG) 1 biopsy specimens and radical prostatectomy specimens. Between January 2012 and May 2018, 733 patients underwent robot-assisted radical prostatectomy. Patients whose original biopsy specimens from outside hospitals were reviewed by a urological pathology expert Okayama University Hospital were included. Patients who had received neoadjuvant hormonal therapy were excluded. Logistic regression analysis was used to identify predictors of upgrading among GGG 1 diagnoses. A total of 403 patients were included in the present study. Agreement in GGG between initial and second-opinion diagnoses was present in 256 cases (63.5%). Although opinion-matched cases improved concordance between biopsy and prostatectomy specimen GGG compared with single-opinion cases (initial, 35.2%; second-opinion, 36.5%; matched, 41.4%), 71% (56/79) of cases classified as GGG 1 were upgraded after prostatectomy. Multivariate analysis revealed that prostate-specific antigen density and Prostate Imaging Reporting and Data System version 2 score were significant predictors of upgrading (odds ratio, 1.10; P=0.01; and odds ratio, 1.88; P=0.03, respectively). In conclusion, the GGG concordance rate between needle-core biopsy and radical prostatectomy specimens was higher in opinion-matched cases; however, 71% of opinion-matched GGG1 cases were upgraded after robot-assisted radical prostatectomy. Urologists should propose treatment strategies or further biopsy rather than active surveillance for patients with GGG1 and a high PSAD and/or PI-RADS score.

    DOI: 10.3892/mco.2020.1996

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  • Differentiation of Small (≤ 4 cm) Renal Masses on Multiphase Contrast-Enhanced CT by Deep Learning. 査読

    Tanaka T, Huang Y, Marukawa Y, Tsuboi Y, Masaoka Y, Kojima K, Iguchi T, Hiraki T, Gobara H, Yanai H, Nasu Y, Kanazawa S

    AJR. American journal of roentgenology   1 - 8   2020年1月

  • Pilot evaluation of a HER2 testing in non-small-cell lung cancer. 査読

    Hotta K, Yanai H, Ohashi K, Ninomiya K, Nakashima H, Kayatani H, Takata M, Kiura K

    Journal of clinical pathology   2019年12月

  • Histologic Appearance and Immunohistochemistry of DNA Mismatch Repair Protein and p53 in Endometrial Carcinosarcoma: Impact on Prognosis and Insights Into Tumorigenesis. 査読

    Saijo M, Nakamura K, Ida N, Nasu A, Yoshino T, Masuyama H, Yanai H

    The American journal of surgical pathology43 ( 11 ) 1493 - 1500   2019年11月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/PAS.0000000000001353

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  • Evaluation of the Usefulness and Convenience of the Kyoto Classification of Gastritis in the Endoscopic Diagnosis of the Helicobacter pylori Infection Status. 査読

    Sakae H, Iwamuro M, Okamoto Y, Obayashi Y, Baba Y, Hamada K, Gotoda T, Abe M, Kono Y, Kanzaki H, Kawano S, Kawahara Y, Tanaka T, Yanai H, Okada H

    Digestion   1 - 8   2019年9月

  • 消化器癌による転移性尿管腫瘍の2例

    河村 香澄, 荒木 元朗, 定平 卓也, 丸山 雄樹, 光井 洋介, 西村 慎吾, 高本 篤, 和田 耕一郎, 谷本 竜太, 杉本 盛人, 小林 泰之, 渡部 昌実, 渡辺 豊彦, 那須 保友, 柳井 広之

    西日本泌尿器科81 ( 4 ) 461 - 466   2019年8月

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    記述言語:日本語   出版者・発行元:西日本泌尿器科学会  

    消化器癌を原発とする転移性尿管腫瘍の2例を経験したため報告する。【症例1】64歳、男性。2007年9月、下行結腸癌に対して下行結腸切除術を施行した。2014年、術後のCTで右尿管腫瘍を指摘され当科へ紹介となった。右尿管鏡検査時の生検病理結果より下行結腸癌の尿管転移と診断し、開腹腫瘍摘出術を行った。術後4ヵ月の時点で肝転移を認めたためTS-1 120mg内服療法を14ヵ月行い、様々な変更を経て現在はXELIRI + Bevacizumab療法8コース目を行っている。肝転移は緩徐に増大中である。【症例2】62歳、男性。2014年12月、多発胃癌に対して幽門側胃切除術、胆嚢摘出術およびRoux-en-Y再建術を施行し、術後TS-1 100mg内服療法を1年間行った。2017年、CTで右水腎症と尿管壁肥厚を指摘され、右尿管鏡検査を行うも狭窄が強く組織は採取できず、検査時の分腎尿細胞診はclass IVであった。再施行した右尿管鏡検査において狭窄尾側を生検したところ浸潤性尿路上皮癌の診断であったため、後腹膜鏡下右腎尿管摘除術を施行した。右尿管は腹膜およびS状結腸と著しく癒着し、漿膜ごと摘除した。病理結果は胃癌の右尿管転移であった。術後weekly PTX 100mgを開始したが骨転移の出現や腹膜転移の進行を認め、PTX + Ramucirumab 1コース施行した後に抗PD-1抗体180mgを5コース行ったが全身状態は徐々に悪化した。術後7ヵ月で緩和療法に移行し、術後11ヵ月で永眠された。転移性尿管腫瘍は術前生検しても診断が難しい場合がある。予後不良な疾患であり、悪性疾患の既往のある尿管腫瘍は転移性尿管腫瘍も鑑別に挙げる必要がある。(著者抄録)

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  • A Comprehensive Review of Ovarian Serous Carcinoma. 査読

    Hatano Y, Hatano K, Tamada M, Morishige KI, Tomita H, Yanai H, Hara A

    Advances in anatomic pathology   2019年7月

  • High-grade glioneuronal tumor with an ARHGEF2-NTRK1 fusion gene. 査読

    Kazuhiko Kurozumi, Yoshiko Nakano, Joji Ishida, Takehiro Tanaka, Masatomo Doi, Junko Hirato, Akihiko Yoshida, Kana Washio, Akira Shimada, Takashi Kohno, Koichi Ichimura, Hiroyuki Yanai, Isao Date

    Brain tumor pathology36 ( 3 ) 121 - 128   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Here, we report a highly unusual case of high-grade glioneuronal tumor with a neurotrophic tropomyosin receptor kinase (NTRK) fusion gene. A 13-year-old girl presented with headache and vomiting and MRI detected two cystic lesions bilaterally in the frontal areas with surrounding edema. The left larger tumor was removed by left frontal craniotomy. The tumor was diagnosed as a high-grade glioneuronal tumor, unclassified. Methylation profiling classified it as a diffuse leptomeningeal glioneuronal tumor (DLGNT) with low confidence. This tumor showed genotypes frequently found in DLGNT such as 1p/19q codeletion without IDH mutation and, however, did not have the typical DLGNT clinical and histological features. RNA sequencing identified an ARHGEF2 (encoding Rho/Rac guanine nucleotide exchange factor 2)-NTRK1 fusion gene. The presence of recurrent NTRK fusion in glioneuronal tumors has an important implication in the clinical decision making and opens up a possibility of novel targeted therapy.

    DOI: 10.1007/s10014-019-00345-y

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  • Contrast-enhanced Computed Tomography-Guided Percutaneous Cryoablation of Renal Cell Carcinoma in a Renal Allograft: First Case in Asia. 査読

    Tsuboi I, Araki M, Fujiwara H, Iguchi T, Hiraki T, Arichi N, Kawamura K, Maruyama Y, Mitsui Y, Sadahira T, Kubota R, Nishimura S, Sako T, Takamoto A, Wada K, Kobayashi Y, Watanabe T, Yanai H, Kitagawa M, Tanabe K, Sugiyama H, Wada J, Shiina H, Kanazawa S, Nasu Y

    Acta medica Okayama73 ( 3 ) 269 - 272   2019年6月

  • Successful Treatment of Metastatic Urothelial Carcinoma after Accurate Diagnosis by Immunohistochemistry. 査読

    Makimoto G, Nishimori H, Kondo R, Yanai H, Sugimoto M, Oda N, Kubo T, Hotta K, Tabata M, Kiura K, Maeda Y

    Acta medica Okayama73 ( 3 ) 279 - 284   2019年6月

  • A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY). 査読

    Ninomiya K, Hata T, Yoshioka H, Ohashi K, Bessho A, Hosokawa S, Ishikawa N, Yamasaki M, Shibayama T, Aoe K, Kozuki T, Harita S, Ueda Y, Murakami T, Fujimoto N, Yanai H, Toyooka S, Takata M, Hotta K, Kiura K, HER2-CS Network

    Chest   2019年5月

  • 高位精巣摘除術後14年後に再発をきたしたStage I期セミノーマの1例(VERY LATE RELAPSE AND MANAGEMENT OF CLINICAL STAGE I SEMINOMA AFTER ORCHIECTOMY: A CASE REPORT)

    和田里 章悟, 定平 卓也, 高本 篤, 丸山 雄樹, 光井 洋介, 和田 耕一郎, 谷本 竜太, 杉本 盛人, 小林 泰之, 荒木 元朗, 渡邉 昌実, 渡邉 豊彦, 那須 保友, 柳井 広之

    西日本泌尿器科81 ( 1 ) 45 - 48   2019年2月

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    記述言語:英語   出版者・発行元:西日本泌尿器科学会  

    Stage I期セミノーマの手術後には補助治療を行わず経過観察とするsurveillanceが現在の主流となっており、再発率は13〜20%と言われている。補助治療の有無によらず、再発の大半は手術後2年以内が占める。以降の再発は晩期再発と呼ばれ区別されているが、そのリスク因子は明確になっていない。手術後5年以降の再発は0.8%〜2.5%と報告されており、術後10年を超えての再発はさらに稀である。今回、我々は高位精巣摘除術14年後に発生したセミノーマ晩期再発を経験したので、若干の文献的考察を加え報告する。症例は40代、男性。右下腿浮腫、総腸骨リンパ節の腫大、骨盤内腫瘤を指摘され当科紹介受診した。患者は前医受診の14年前に右精巣腫瘍に対し高位精巣摘除術を行われており、セミノーマpT2N0M0 Stage IBとして術後6年間のフォローの後に終診となっていた。当科受診時にはLDH 667 U/l(120〜240U/l)、β-hCG 17.5mIU/l(<0.5mIU/l)と高値を認め、骨盤内腫瘤生検によりセミノーマの再発と診断、救済化学療法としてBEP3コース、VeIP療法を3コース施行した。VeIP療法施行後、骨盤内残存腫瘤の切除を行った。摘出標本は壊死組織のみでviable cellは認めず、術後7ヵ月時点では局所再発、転移は認めていない。(著者抄録)

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  • Burned-out Prostate Cancer ? Primary Metastatic Cancer Not Detected on Repeat Biopsy. 査読

    Mitsui Y, Sadahira T, Maruyama Y, Wada K, Tanimoto R, Sugimoto M, Araki M, Watanabe M, Yanai H, Watanabe T, Nasu Y

    Acta medica Okayama72 ( 6 ) 605 - 609   2018年12月

  • Quality indicators for cervical cancer care in Japan. 査読

    Watanabe T, Mikami M, Katabuchi H, Kato S, Kaneuchi M, Takahashi M, Nakai H, Nagase S, Niikura H, Mandai M, Hirashima Y, Yanai H, Yamagami W, Kamitani S, Higashi T

    Journal of gynecologic oncology29 ( 6 ) e83   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3802/jgo.2018.29.e83

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  • 分節性に多発した神経鞘腫の1例

    河田 真理子, 山崎 修, 竹原 彩, 鈴木 大介, 岩月 啓氏, 柳井 広之

    西日本皮膚科80 ( 5 ) 446 - 449   2018年10月

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    記述言語:日本語   出版者・発行元:日本皮膚科学会-西部支部  

    59歳、女性。小児期から左側腹部に限局して、軟らかい小型の結節を数個認めていた。3年前から徐々に硬化、増大し、発赤、圧痛を伴ってきたため当科を受診した。限局性に結節が多発し、神経線維腫症1型や2型の他症状はなく、臨床的には分節型神経線維腫症を考えた。生検にて悪性末梢神経鞘腫瘍の合併を疑い、拡大切除した。全摘標本では多発する結節は神経鞘腫の多彩な組織像を示した。術後7年間、再発や転移を認めなかった。(著者抄録)

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  • β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma). 査読

    Suzuki Y, Ichihara S, Kawasaki T, Yanai H, Kitagawa S, Shimoyama Y, Nakamura S, Nakaguro M

    Virchows Archiv : an international journal of pathology   1 - 5   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00428-018-2370-9

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  • Oncological impact of neoadjuvant hormonal therapy on permanent iodine-125 seed brachytherapy in patients with low- and intermediate-risk prostate cancer 査読

    Atsushi Takamoto, Ryuta Tanimoto, Kensuke Bekku, Motoo Araki, Takuya Sadahira, Koichiro Wada, Shin Ebara, Norihisa Katayama, Hiroyuki Yanai, Yasutomo Nasu

    International Journal of Urology25 ( 5 ) 507 - 512   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing  

    Objectives: To determine whether neoadjuvant hormonal therapy improves oncological outcomes of patients with localized prostate cancer treated with permanent brachytherapy. Methods: Between January 2004 and November 2014, 564 patients underwent transperineal ultrasonography-guided permanent iodine-125 seed brachytherapy. We retrospectively analyzed low- or intermediate-risk prostate cancer based on the National Comprehensive Cancer Network guidelines. The clinical variables were evaluated for influence on biochemical recurrence-free survival, progression-free survival, cancer-specific survival and overall survival. Results: A total of 484 patients with low-risk (259 patients) or intermediate-risk disease (225 patients) were evaluated. Of these, 188 received neoadjuvant hormonal therapy. With a median follow up of 71 months, the 5-year actuarial biochemical recurrence-free survival rates of patients who did and did not receive neoadjuvant hormonal therapy were 92.9% and 93.6%, respectively (P = 0.2843). When patients were stratified by risk group, neoadjuvant hormonal therapy did not improve biochemical recurrence-free survival outcomes in low- (P = 0.8949) or intermediate-risk (P = 0.1989) patients. The duration or type of hormonal therapy was not significant in predicting biochemical recurrence. In a multivariate analysis, Gleason score, pretreatment prostate-specific antigen, clinical T stage, and prostate dosimetry, primary Gleason score and positive core rate were significant predictive factors of biochemical recurrence-free survival, whereas neoadjuvant hormonal therapy was insignificant. Furthermore, neoadjuvant hormonal therapy did not significantly influence progression-free survival, cancer-specific survival or overall survival. Conclusions: In patients with low- or intermediate-risk disease treated with permanent prostate brachytherapy, neoadjuvant hormonal therapy does not improve oncological outcomes. Its use should be restricted to patients who require prostate volume reduction.

    DOI: 10.1111/iju.13555

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  • Japan Society of Gynecologic Oncology guidelines 2015 for the treatment of vulvar cancer and vaginal cancer. 査読

    Toshiaki Saito, Tsutomu Tabata, Hitoshi Ikushima, Hiroyuki Yanai, Hironori Tashiro, Hitoshi Niikura, Takeo Minaguchi, Toshinari Muramatsu, Tsukasa Baba, Wataru Yamagami, Kazuya Ariyoshi, Kimio Ushijima, Mikio Mikami, Satoru Nagase, Masanori Kaneuchi, Nobuo Yaegashi, Yasuhiro Udagawa, Hidetaka Katabuchi

    International journal of clinical oncology23 ( 2 ) 201 - 234   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Vulvar cancer and vaginal cancer are relatively rare tumors, and there had been no established treatment principles or guidelines to treat these rare tumors in Japan. The first version of the Japan Society of Gynecologic Oncology (JSGO) guidelines for the treatment of vulvar cancer and vaginal cancer was published in 2015 in Japanese. OBJECTIVE: The JSGO committee decided to publish the English version of the JSGO guidelines worldwide, and hope it will be a useful guide to physicians in a similar situation as in Japan. METHODS: The guideline was created according to the basic principles in creating the guidelines of JSGO. RESULTS: The guidelines consist of five chapters and five algorithms. Prior to the first chapter, basic items are described including staging classification and history, classification of histology, and definition of the methods of surgery, radiation, and chemotherapy to give the reader a better understanding of the contents of the guidelines for these rare tumors. The first chapter gives an overview of the guidelines, including the basic policy of the guidelines. The second chapter discusses vulvar cancer, the third chapter discusses vaginal cancer, and the fourth chapter discusses vulvar Paget's disease and malignant melanoma. Each chapter includes clinical questions, recommendations, backgrounds, objectives, explanations, and references. The fifth chapter provides supplemental data for the drugs that are mentioned in the explanation of clinical questions. CONCLUSION: Overall, the objective of these guidelines is to clearly delineate the standard of care for vulvar and vaginal cancer with the goal of ensuring a high standard of care for all women diagnosed with these rare diseases.

    DOI: 10.1007/s10147-017-1193-z

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  • 日本産科婦人科学会婦人科腫瘍委員会プロジェクト(パート1) 性成熟期の女性に発症する疾患の発症と臨床的対応 転移、再発を来した子宮筋腫症例の検討 臨床的事項を中心に

    牛嶋 公生, 片渕 秀隆, 小林 裕明, 田代 浩徳, 三上 幹男, 宮本 新吾, 柳井 広之, 遠隔再発, 遠隔転移を来した子宮間葉系腫瘍の臨床病理学的検討に関する小委員会

    日本婦人科腫瘍学会雑誌36 ( 2 ) 177 - 180   2018年4月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • Gastric neuroendocrine tumor arising from heterotopic pancreas 査読

    Takehiro Tanaka, Rika Omote, Noriko Okazaki, Hiroyuki Yanai, Tadashi Yoshino

    Clinical Journal of Gastroenterology11 ( 1 ) 34 - 37   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Tokyo  

    There are few English reports on secondary tumors from heterotopic pancreas. Here, we describe a case of gastric neuroendocrine tumor (NET) arising from heterotopic pancreas. A 72-year-old woman underwent esophagogastroduodenoscopy as part of a general health check-up. An endoscopic examination revealed a submucosal tumor on the greater curvature of the gastric body. Laparoscopic and endoscopic cooperative surgery was performed. Histological diagnosis concluded that it was a Grade 1 NET arising from heterotopic pancreas. We report this extremely rare case of a NET presenting as a submucosal tumor, considered to have originated from heterotopic pancreatic tissue.

    DOI: 10.1007/s12328-017-0795-3

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  • Histopathological and genetic review of phosphaturic mesenchymal tumours, mixed connective tissue variant. 査読 国際誌

    Yuichi Yamada, Izumi Kinoshita, Kohashi Kenichi, Hidetaka Yamamoto, Takeshi Iwasaki, Hiroshi Otsuka, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yuki Kuma, Nokitaka Setsu, Yuki Koga, Yumi Honda, Takeshi Inoue, Hiroyuki Yanai, Kyoko Yamashita, Ichiro Ito, Mitsuru Takahashi, Shouichi Ohga, Masutaka Furue, Yasuharu Nakashima, Yoshinao Oda

    Histopathology72 ( 3 ) 460 - 471   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Phosphaturic mesenchymal tumour, mixed connective tissue variant (PMT-MCT), is a tumour of uncertain differentiation, characterised by 'smudgy/grungy' calcification and vitamin D-resistant phosphaturic osteomalacia. Fibroblast growth factor (FGF)23 is recognised as a reliable marker of PMT-MCT, but quantitative evaluation has never been performed. We reviewed cases of tumour-associated osteomalacia or histologically definitive PMT-MCT without osteomalacia using histological, immunohistochemical and genetic methods and evaluated the diagnostic significance of these findings. METHODS AND RESULTS: A total of 19 tumours from 14 cases diagnosed previously as PMT-MCT were retrieved, on which immunohistochemical staining, reverse transcription-polymerase chain reaction (RT-PCR) and fluorescence in-situ hybridisation (FISH) analysis were performed. Histologically, fibrous capsule, calcification and giant cell reaction tended to be observed in soft-tissue PMT-MCT, while PMT-MCT of bone and multiple PMT-MCT showed an infiltrative growth pattern. The immunohistochemical results were as follows: the tumour cells were positive for FGF23 (nine of 12, 75%), FGFR1 (11 of 11, 100%), CD56 (12 of 14, 85.7%) and E26 oncogene homologue (ERG) (5 of 13, 38.4%). The sole malignant tumour was positive for p53. FGF23 mRNA was detected in seven of 14 formalin-fixed paraffin-embedded (FFPE) specimens and all five frozen specimens by RT-PCR. The level of FGF23 mRNA, which was determined by real-time PCR, varied among the phosphaturic cases. Two of 17 tumours were positive for FGFR1 gene rearrangement. CONCLUSIONS: It was considered that PMT-MCT is a histopathological entity with or without phosphaturia, with varying levels of FGF23 mRNA, and with or without fibronectin 1 (FN1)-FGFR1 fusion gene. The authors propose that the histology of PMT-MCT differs depending on its location, such as bone or soft tissue, which could complicate the differential diagnosis.

    DOI: 10.1111/his.13377

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  • A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma 査読

    Toshinori Omori, Tomohiro Fujiwara, Toshiyuki Kunisada, Ken Takeda, Joe Hasei, Aki Yoshida, Hiroyuki Yanai, Toshifumi Ozaki

    Journal of Orthopaedic Science24 ( 2 ) 377 - 381   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier  

    DOI: 10.1016/j.jos.2016.12.011

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  • Japan Society of Gynecologic Oncology guidelines 2015 for thetreatment of vulvar cancer and vaginal cance 査読

    T. Saito, T. Tabata, H. Ikushima, H. Yanai, H. Tashiro, H. Niikura, T. Minaguchi, T. Muramatsu, T. Baba, W. Yamagami, K. Ariyoshi, K. Ushijima, M. Mikami, S. Nagase, M. Kaneuchi, N. Yaegashi, Y. Udagawa, H. Katabuchi

    International Journal of Clinical Oncology23   201 - 234   2018年

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  • Clinicopathologic Diversity of Undifferentiated Sarcoma With BCOR-CCNB3 Fusion: Analysis of 11 Cases With a Reappraisal of the Utility of Immunohistochemistry for BCOR and CCNB3 査読

    Atsuji Matsuyama, Eisuke Shiba, Yoshihisa Umekita, Kanae Nosaka, Takihiro Kamio, Hiroyuki Yanai, Chika Miyasaka, Reiko Watanabe, Ichiro Ito, Tomoko Tamaki, Shinichi Hayashi, Masanori Hisaoka

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY41 ( 12 ) 1713 - 1721   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Undifferentiated sarcoma harboring the BCOR-CCNB3 fusion is characterized by its predilection to affect skeletons of adolescent males, cellular small round/spindle cell morphology, and CCNB3 immunoreactivity. We analyzed 11 cases of BCOR-CCNB3 sarcoma, 10 of which were identified in a reverse transcription-polymerase chain reaction-based screen of 85 patient samples recorded in our database as unclassified small round or spindle cell sarcomas. BCOR rearrangements were confirmed by fluorescence in situ hybridization in 8 tumors. All patients were males aged between 6 and 31 years. In addition to 5 tumors in soft tissue and 4 in the axial or appendicular skeletons, which are typical locations, a tumor was located in the paranasal sinus and another in the lung. Microscopically, the tumors comprised proliferating atypical spindle and/or small round cells with diverse morphologic features such as small concentric whorls, myxoid stroma, a hemangiopericytomatous appearance, and/or hyalinized collagen resembling a solitary fibrous tumor, and angiomatous or slit-like spaces containing extravasated erythrocytes. Tumor cells were immunoreactive to CCNB3 (9/11), BCOR (10/10), TLE1 (6/10), bcl-2 (9/11), CD99 (8/10), CD56 (8/10), c-kit (4/10), and cyclin D1 (10/10). In an immunohistochemical analysis of an additional 412 small round or spindle cell tumors, CCNB3 was detected in 6 (1.5%) and BCOR in 18 (4.4%). Our analysis highlights the varying clinicopathologic features of this tumor, which partially overlap with other small round or spindle cell tumors, including solitary fibrous tumor and vascular tumors. Because CCNB3 and BCOR immunohistochemistry lacks adequate sensitivity and specificity, a molecular genetic approach remains essential for diagnosis.

    DOI: 10.1097/PAS.0000000000000934

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  • 淡明細胞型腎細胞癌との鑑別にGiemsa染色が有用であった血管肉腫の1例 査読

    有安 早苗, 柳井 広之, 福田 由美子, 中桐 智香子, 佐藤 正和, 園部 宏

    日本臨床細胞学会雑誌56 ( 6 ) 297 - 302   2017年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(公社)日本臨床細胞学会  

    背景:穿刺吸引細胞診にて淡明細胞型腎細胞癌との鑑別が問題となった血管肉腫を経験し、その診断にGiemsa染色が有用であったので報告する。症例:患者は50歳代、男性。体調不良の精査時にCTにて後腹膜腫瘍および多発転移を認めた。転移リンパ節より穿刺吸引細胞診および組織生検が行われた。細胞診パパニコロウ染色標本では、N/C比が低く、細胞質がレース状で、核小体の目立つ明るい核を有する細胞が、上皮様結合を示す集塊で認められた。腎明細胞癌との鑑別が問題となったが、Giemsa染色標本では明瞭な赤血球内包像を認め、血管肉腫を疑った。生検組織は大型円形〜楕円形核をもつ細胞が密に増殖する像であった。免疫染色で腫瘍細胞はCD31、D2-40陽性を示し、血管肉腫と診断された。結論:血管肉腫はまれな腫瘍である。なかでも後腹膜血管肉腫は、画像診断が難しく、予後不良な腫瘍である。よって、穿刺吸引細胞診断は重要な位置づけにあり、精度の高い診断が望まれる。その細胞診断においてはGiemsa染色での赤血球内包像が有用であった。(著者抄録)

    DOI: 10.5795/jjscc.56.297

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  • 転移,再発を来した子宮筋腫症例の臨床病理学的検討

    牛嶋公生, 片渕秀隆, 小林裕明, 田代浩徳, 三上幹男, 宮本新吾, 柳井広之

    日本婦人科腫よう学会雑誌35 ( 3 ) 371   2017年6月

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    記述言語:日本語  

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  • Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue with Plasma Cell Differentiation: Periodic Acid-Schiff Reaction-Positive Dutcher Body is a Diagnostic Clue to Distinguish it from Plasmacytoma 査読

    Atsuko Nasu, Takuro Igawa, Hiaki Sato, Hiroyuki Yanai, Tadashi Yoshino, Yasuharu Sato

    DIAGNOSTIC CYTOPATHOLOGY45 ( 6 ) 547 - 551   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    We herein report a case of primary parotid extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with Dutcher bodies. An 82-year-old man presented with a 4 cm x 2.5 cm mass in the left parotid region. Positron emission tomography/computed tomography (PET/CT) showed localized abnormal fluorodeoxyglucose (FDG) uptake in the left parotid gland and lymph nodes of the left cervical region. Fine needle aspiration (FNA) cytology of the left parotid gland showed lymphoplasmacytoid cells with periodic acid-Schiff (PAS)-positive Dutcher bodies. A subsequent excisional biopsy showed sheets of small- to medium-sized neoplastic B cells with abundant IgM in the cytoplasm as detected by immunohistochemistry. A diagnosis of stage II MALT lymphoma was made, but the patient did not receive therapeutic intervention. As previously reported, Dutcher bodies are mainly observed in B-cell neoplasms with IgM production. Because these characteristic intranuclear inclusions can be easily observed by PAS staining, the presence of PAS reaction-positive Dutcher bodies in FNA cytology can serve as a clue to differentially diagnose MALT lymphoma from plasmacytoma. (C). 2017 Wiley Periodicals, Inc.

    DOI: 10.1002/dc.23691

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  • Verification of Implant Surface Modification by a Novel Processing Method 査読

    Yoshiki Okada, Nobuhiro Abe, Noriyuki Hisamori, Toshiaki Kaneeda, Shigeaki Moriyama, Hitoshi Ohmori, Masayoshi Mizutani, Hiroyuki Yanai, Yoshio Nakashima, Yusuke Yokoyama, Toshifumi Ozaki

    ACTA MEDICA OKAYAMA71 ( 1 ) 49 - 57   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Metals have been used clinically as biomaterials, especially in the orthopaedic and dental fields. Metals used as implants wear at contact surfaces, producing metal particles and metal ions that may be harmful. Newly developed metal implants and methods of implant surface modification are currently under scrutiny. We evaluated the use of electrolytic in-process dressing (ELID) as a surface finishing method for metal implants. Metal implants processed using the ELID method (ELID group) or not processed (Non-ELID group) were inserted surgically into rabbit femurs. The rabbits were sacrificed postoperatively over a 24-week period. We assessed the concentrations of the cytokines, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-a, the resistance to implant pull-out, and histopathology at the implant site. There was no significant difference between the groups regarding the cytokine concentrations or implant pull-out resistance. Many particles indicating wear around the implant were noted in the Non-ELID group (n=10) but not the ELID group (n=13), while a fibrous membrane adhering to the every implant was noted in the ELID group. The formation of a fibrous membrane rather than metal particles in the ELID group may indicate improved biocompatibility, and it suggests that ELID may prevent corrosion in the areas of contact.

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  • Trastuzumab Emtansine in HER2+Recurrent Metastatic Non-Small-Cell Lung Cancer: Study Protocol 査読

    Kadoaki Ohashi, Katsuyuki Hotta, Taizo Hirata, Keisuke Aoe, Toshiyuki Kozuki, Kiichiro Ninomiya, Hiroe Kayatani, Hiroyuki Yanai, Shinichi Toyooka, Shiro Hinotsu, Minoru Takata, Katsuyuki Kiura

    CLINICAL LUNG CANCER18 ( 1 ) 92 - 95   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CIG MEDIA GROUP, LP  

    The treatment outcome has been unsatisfactory for patients with non small-cell lung cancer (NSCLC) refractory to standard first-line chemotherapy. Trastuzumab emtansine (T-DM1), an anti-HER2 antibody conjugated with a vinca alkaloid, has been approved for clinical use in HER2+ breast cancer in many countries. Approximately 5% of NSCLC tumors possess HER2 alterations, and T-DM1 has shown excellent antitumor effects against HER2+ lung cancer cell lines in preclinical models. Therefore, we hypothesized that T-DM1 could significantly inhibit the growth of HER2+ lung cancers. We have launched a nonrandomized phase II trial of T-DM1 monotherapy for patientg with HER2+ lung cancers. The major eligibility criteria are as follows: age >= 20 years, pathologically diagnosed NSCLC with documented HER2 positivity (immunohistochemistry 3+, both immunohistochemistry 2+ and fluorescence in situ hybridization positive, or exon 20 insertion mutation), and previous chemotherapy. Thirty patients will receive T-DM1 3.6 mg/kg every 3 weeks. The primary endpoint is the overall response rate. This trial will provide information on whether T-DM1 monotherapy is effective against HER2+ lung cancer. (C) 2016 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.cllc.2016.06.014

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  • Comparative study on driver mutations in primary and metastatic melanomas at a single Japanese institute: A clue for intra- and inter-tumor heterogeneity 査読

    Tatsuya Kaji, Osamu Yamasaki, Minoru Takata, Masaki Otsuka, Toshihisa Hamada, Shin Morizane, Kenji Asagoe, Hiroyuki Yanai, Yoji Hirai, Hiroshi Umemura, Keiji Iwatsuki

    JOURNAL OF DERMATOLOGICAL SCIENCE85 ( 1 ) 51 - 57   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Background: Searching for driver mutations in melanoma is critical to understanding melanoma genesis, progression and response to therapy.
    Objectives: We aimed to investigate the frequency and pattern of driver mutations in Japanese primary and metastatic melanomas including cases of unknown primary origin, in relation to their clinicopathologic manifestations.
    Methods: Seventy-seven samples from 60 patients with melanoma were screened for 70 driver mutations of 20 oncogenes by Sequenom MelaCarta MassARRAY, and the results for primary and metastatic melanomas were compared.
    Results: Of 77 tissue samples, BRAFV60 OE was detected in 21 samples (27%), CDK4 R24C in 7, EPHB6 G404S in 6, BRAF V600 K in 2, NEK10 E379 K in 2, and CDK4 R24H, NRAS Q61 K, NRAS Q61R, KRAS GI2A, KIT L576P, KIT V559A, ERBB4 E452 K, and PDGFRA E996 K in one sample each. No driver mutations related to the MAPK cascade including MS and BRAF were detected in the chronically sun-damaged (CSD) group of melanoma. Dual or triple driver mutations were found in four of 40 (10%) samples from the primary melanomas, and three of 37 (8%) of the metastatic melanomas. Fourteen of 26 (54%) samples of non-CSD melanoma, and 3 of 6 (50%) melanomas of unknown primary origin had the BRAF V600E mutation. Mutations in membrane-bound receptors including KIT, ERBB4 and EPHB6 were detected in 8 of 77 (10%) samples. Of 17 pairs of primary and metastatic melanomas from the same patient, the primary mutation pattern was changed to a novel one in three cases, and only one of the plural mutations in the primary melanoma was found in the metastatic lesions in two cases.
    Conclusions: BRAF V600E is a predominant mutation in non-CSD melanoma and melanomas of unknown primary origin. Mutational heterogeneity may exist in the primary melanoma (intra-tumor heterogeneity), and between the primary and metastatic lesions (inter-tumor heterogeneity). (C) 2016 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.jdermsci.2016.10.006

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  • 治療に難渋した壊死性好酸球性心筋炎の1例

    小出 祐嗣, 中村 一文, 木村 朋生, 中川 晃志, 三好 亨, 西井 伸洋, 伊藤 浩, 大澤 晋, 笠原 慎吾, 田中 健大, 柳井 広之, 安藤 翠, 大郷 恵子, 山中 俊明

    心臓49   159 - 167   2017年

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  • 乳児Atypical teratoid/rhabdid tumorに対する放射線治療および分子生物学的分類と予後との関連について.

    大谷理浩, 市川智継, 黒住和彦, 安原隆雄, 鷲尾佳奈, 嶋田 明, 片山敬久, 勝井邦彰, 柳井広之, 伊達 勲

    脳神経外科45 ( 2 ) 147 - 154   2017年

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  • 子宮体部原発のAFP産生hepatoid adenocarcinomaの稀な一例

    中村 春樹, 永井 景, 小川 憲二, 安川 久吉, 赤田 忍, 河原 邦光, 柳井 広之

    日本婦人科腫瘍学会雑誌35 ( 1 ) 35 - 42   2017年

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  • Prognostic impact of radiation therapy and molecular classification of infant atypical teratoid/rhabdoid tumors 査読

    Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Takao Yasuhara, Kana Washio, Akira Shimada, Norihisa Katayama, Kuniaki Katsui, Hiroyuki Yanai, Isao Date

    Neurological Surgery, No shinkei geka. Neurological surgery45 ( 2 ) 147 - 154   2017年

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    記述言語:英語  

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  • 前頭葉に発生し、てんかん原性を示した髄膜腫合併髄膜血管腫症の1例

    河原 明奈, 伏見 聡一郎, 板倉 淳哉, 藤澤 真義, 小林 勝弘, 林 裕美子, 伊達 勲, 上利 崇, 柳井 広之, 松川 昭博

    診断病理34 ( 1 ) 46 - 50   2017年

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  • Adenovirus vector carrying REIC/DKK-3 gene: neoadjuvant intraprostatic injection for high-risk localized prostate cancer undergoing radical prostatectomy

    Kumon H, Ariyoshi Y, Sasaki K, Sadahira T, Araki M, Ebara S, Yanai H, Watanabe M, Nasu Y

    Cancer Gene Therapy23 ( 11 ) 400 - 409   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/cgt.2016.53

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  • CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine 査読

    Nobuhiko Ohnishi, Katsuyoshi Takata, Tomoko Miyata-Takata, Yasuharu Sato, Akira Tari, Yuka Gion, Mai Noujima-Harada, Kohei Taniguchi, Tetsuya Tabata, Keina Nagakita, Shizuma Omote, Hiroyuki Takahata, Masaya Iwamuro, Hiroyuki Okada, Yoshinobu Maeda, Hiroyuki Yanai, Tadashi Yoshino

    CANCER SCIENCE107 ( 11 ) 1687 - 1695   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Follicular lymphoma (FL) shows co-expression of B-cell lymphoma 2 (BCL2) and CD10, whereas downexpression of CD10 is occasionally experienced in gastrointestinal (GI) FL with unknown significance. Gastrointestinal FL is a rare variant of FL, and its similarity with mucosa-associated lymphoid tissue lymphoma was reported. We investigated the clinicopathological and genetic features of CD10 downexpressed (CD10(down)) GI-FL. The diagnosis of CD10(down) FL was carried out with a combination of pathological and molecular analyses. The incidence of CD10(down) GI-FL was shown in 35/172 (20.3%) cases, which was more frequent than nodal FL (3.5%, P < 0.001). The difference was additionally significant between GI-FL and nodal FL when the analysis was confined to primary GI-FL (55.2% vs 3.5%, P < 0.001). Compared to CD10(+) GI-FL, CD10(down) GI-FL significantly involved the stomach or large intestine (P = 0.015), and additionally showed the downexpression of BCL6 (P < 0.001). The follicular dendritic cell meshwork often showed a duodenal pattern in the CD10(down) group (P = 0.12). Furthermore, a lymphoepithelial lesion was observed in 5/12 (40%) gastric FL cases, which indicated caution in the differentiation of mucosa-associated lymphoid tissue lymphoma. Molecular analyses were undertaken in seven cases of CD10(down) GI-FL, and an identical clone was found between CD10(down) follicles and CD10(+)BCL2(+) neoplastic follicles. In the diagnosis of cases with CD10(down) BCL2(+) follicles, careful examination with molecular studies should be carried out.

    DOI: 10.1111/cas.13031

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  • Histological spectrum of angiofibroma of soft tissue: histological and genetic analysis of 13 cases 査読

    Yuichi Yamada, Hidetaka Yamamoto, Kenichi Kohashi, Takeaki Ishii, Kunio Iura, Akira Maekawa, Hirofumi Bekki, Hiroshi Otsuka, Kyoko Yamashita, Hiroyuki Tanaka, Tsubasa Hiraki, Munenori Mukai, Atsuko Shirakawa, Yoko Shinnou, Mari Jinno, Hiroyuki Yanai, Kenichi Taguchi, Yoshihiko Maehara, Yukihide Iwamoto, Yosinao Oda

    HISTOPATHOLOGY69 ( 3 ) 459 - 469   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    AimsAngiofibroma of soft tissue (AFST) is a rare soft tissue neoplasm characterized by a fibroblastic cytomorphology and a prominent vascular structure. AFSTs possess a novel fusion gene, i.e. NCOA2-AHRR/AHRR-NCOA2 or GTF2I-NCOA2, providing a useful approach to diagnosing AFST. Morphologically, AFSTs span a wide spectrum, making diagnosis a challenge. The aim of this study was to review AFST cases and to report previously unknown histological features, which we confirmed by genetic analysis.
    Methods and resultsWe reviewed 276 cases diagnosed as solitary fibrous tumours/haemangiopericytomas (232 cases), unclassified tumours of fibroblastic differentiation (36 cases), and recently diagnosed AFSTs (eight cases), and retrieved 13 cases compatible with AFST. Immunohistochemical staining was performed for these cases, all 13 of which were analysed by reverse transcription polymerase chain reaction and fluorescence in-situ hybridization. The histological findings were as follows: amianthoid fibres, extravasation of red blood cells, haemosiderin deposition, aggregates of foamy histiocytes, cystic change, necrosis, and haemorrhage. Immunohistochemically, the tumour cells were positive for epithelial membrane antigen (four of 13 cases), desmin (six of 13 cases), CD163 (13 of 13 cases), CD68 (seven of 13 cases), oestrogen receptor (13 of 13 cases), progesterone receptor (three of 13 cases), and STAT6 (one of 13 cases, weak nuclear staining), but they were negative for CD34, -smooth muscle actin, muscle-specific actin, S100, pan-cytokeratin, MDM2, and CDK4. The AHRR-NCOA2 fusion gene was detected in eight cases, and NCOA2 gene rearrangement in nine cases.
    ConclusionWe revealed the previously unreported histological variation and immunohistochemical findings of AFST, and confirmed them by using genetic methods. The results suggested that AFST should be considered in the diagnosis of fibrous or fibrohistiocytic tumours with the above histological features.

    DOI: 10.1111/his.12943

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  • A Case of Focal Bone Marrow Reconversion Mimicking Bone Metastasis: The Value of (111)Indium Chloride 査読

    Takashi Tanaka, Hideo Gobara, Ryota Inai, Toshihiro Iguchi, Akihiro Tada, Shuhei Sato, Hiroyuki Yanai, Susumu Kanazawa

    ACTA MEDICA OKAYAMA70 ( 4 ) 285 - 289   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We present a case of a 66-year-old man with esophageal carcinoma. (18)Fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) for evaluating distant metastasis and staging revealed F-18-FDG uptake in the third lumbar vertebra and other vertebrae. Magnetic resonance imaging could not differentiate bone metastases from benign bone lesions. We considered the possibility of bone marrow reconversion. (111)Indium chloride (In-111-Cl-3 ) scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT) revealed erythroid bone marrow components in the bone lesions. The diagnosis of bone marrow reconversion was pathologically confirmed by a bone biopsy of the third lumbar vertebra. The patient underwent esophagectomy and has remained disease-free in the 2 years since. To the best of our knowledge, this is the first report to describe the usefulness of In-111-Cl-3 with SPECT/CT for the diagnosis of bone marrow reconversion.

    DOI: 10.18926/AMO/54505

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  • Expansion of epigenetic alterations in EFEMP1 promoter predicts malignant formation in pancreatobiliary intraductal papillary mucinous neoplasms 査読

    Kazuhiro Yoshida, Takeshi Nagasaka, Yuzo Umeda, Takehiro Tanaka, Keisuke Kimura, Fumitaka Taniguchi, Tomokazu Fuji, Kunitoshi Shigeyasu, Yoshiko Mori, Hiroyuki Yanai, Takahito Yagi, Ajay Goel, Toshiyoshi Fujiwara

    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY142 ( 7 ) 1557 - 1569   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Although limited understanding exists for the presence of specific genetic mutations and aberrantly methylated genes in pancreatobiliary intraductal papillary mucinous neoplasms (IPMNs), the fundamental understanding of the dynamics of methylation expansion across CpG dinucleotides in specific gene promoters during carcinogenesis remains unexplored. Expansion of DNA methylation in some gene promoter regions, such as EFEMP1, one of the fibulin family, with tumor progression has been reported in several malignancies. We hypothesized that DNA hypermethylation in EFEMP1 promoter would expand with the tumor grade of IPMN.
    A sample of 65 IPMNs and 30 normal pancreatic tissues was analyzed. IPMNs were divided into the following three subsets according to pathological findings: 31 with low-grade dysplasia (low grade), 11 with high-grade dysplasia (high grade), and 23 with associated invasive carcinoma (invasive Ca). Mutations in the KRAS or GNAS genes were analyzed by Sanger sequencing, and methylation status of two discrete regions within the EFEMP1 promoter, namely region 1 and region 2, was analyzed by bisulfite sequencing and fluorescent high-sensitive assay for bisulfite DNA (Hi-SA). Expression status of EFEMP1 was investigated by immunohistochemistry (IHC).
    KRAS mutations were detected in 39, 55, and 70 % of low-grade, high-grade, and invasive Ca, respectively. GNAS mutations were observed in 32, 55, and 22 % of low-grade, high-grade, and invasive Ca, respectively. The methylation of individual regions (region 1 or 2) in the EFEMP1 promoter was observed in 84, 91, and 87 % of low-grade, high-grade, and invasive Ca, respectively. However, simultaneous methylation of both regions (extensive methylation) was exclusively detected in 35 % of invasive Ca (p = 0.001) and five of eight IPMNs (63 %) with extensive methylation, whereas 20 of 57 (35.1 %) tumors of unmethylation or partial methylation of the EFEMP1 promoter region showed weak staining EFEMP1 in extracellular matrix (p = 0.422). In addition, extensive EFEMP1 methylation was particularly present in malignant tumors without GNAS mutations and associated with disease-free survival of patients with IPMNs (p < 0.0001).
    Extensive methylation of the EFEMP1 gene promoter can discriminate invasive from benign IPMNs with superior accuracy owing to their stepwise accumulation of tumor progression.

    DOI: 10.1007/s00432-016-2164-x

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  • A Case of Metastatic Urachal Cancer Including a Neuroendocrine Component Treated with Gemcitabine, Cisplatin and Paclitaxel Combination Chemotherapy 査読

    Shin Ebara, Yasuyuki Kobayashi, Katsumi Sasaki, Motoo Araki, Morito Sugimoto, Koichirou Wada, Kei Fujio, Atsushi Takamoto, Toyohiko Watanabe, Hiroyuki Yanai, Yasutomo Nasu

    ACTA MEDICA OKAYAMA70 ( 3 ) 223 - 227   2016年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The present case report describes a case of recurrent and advanced urachal carcinoma including neuroendocrine features with iliac bone metastasis after partial cystectomy and adjuvant chemotherapy consisting of irinotecan and cisplatin in a 32-year-old man. He received gemcitabine/cisplatin/paclitaxel (GCP) combination chemotherapy, consisting of gemcitabin (1,000mg/m(2)) on day 1, 8, cisplatin (70mg/m(2)) on day 1, and paclitaxel (80mg/m(2)) on day 1 and 8. After three cycles of chemotherapy, PET-CT showed complete regression of the disease. So the patient underwent total cystoure-threctomy, and histological examination showed an almost complete pathological response. External beam radiation therapy was also given to the ileac bone metastasis regions. However, PET-CT taken 17 months after the external beam radiation showed multiple lung metastases. He received GCP chemotherapy again, which resulted in a complete response again after three cycles of chemotherapy. This is the first report on GCP chemotherapy used not only as a salvage chemotherapy but also as a rechallenge regimen for metastatic urachal cancer including a neuroendocrine component.

    DOI: 10.18926/AMO/54423

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  • Hypocomplementemic urticarial vasculitis arising in a patient with immunoglobulin G4-related disease 査読

    Mariko Takao, Toshihisa Hamada, Tatsuya Kaji, Kazuko Ikeda-Mizuno, Chinatsu Takehara-Yasuhara, Kouichi Ichimura, Hiroyuki Yanai, Tadashi Yshino, Keiji Iwatsuki

    INTERNATIONAL JOURNAL OF DERMATOLOGY55 ( 4 ) 430 - 433   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    BackgroundHypocomplementemic urticarial vasculitis (HUV) has been defined as a syndrome associated with urticarial lesions caused by leukocytoclastic vasculitis. It has been observed in patients with systemic lupus erythematosus and related conditions. Immunoglobulin G4 (IgG4)-related disease is a lymphoproliferative disorder characterized by sclerosing pancreatitis, retroperitoneal fibrosis, sclerotic cholangitis, acute interstitial nephritis, and Mikulicz's disease, and associated with elevated levels of IgG4 and hypocomplementemia. Various cutaneous lesions may occur in IgG4-related disease.
    MethodsWe report a 74-year-old woman with HUV, followed by systemic organ involvement suggestive of IgG4-related disease. Symptoms included submandibular gland swelling, lymphadenopathy, interstitial nephritis, and a thyroid nodule. Laboratory examinations revealed an elevated serum IgG4 level of 637mg/dl in a total IgG level of 2176mg/dl, and the production of autoantibodies such as rheumatoid factor and antiphospholipid antibodies. In the swollen lymph node, neither clonal proliferation of T or Bcells nor Epstein-Barr virus infection was detected, although the structure had been destroyed by the infiltration of lymphocytes and plasma cells. Among total IgG-producing cells, approximately 40% were positive for IgG4.
    ResultsAll symptoms and abnormal laboratory findings improved in response to oral prednisolone.
    ConclusionsHypocomplementemic urticarial vasculitis may represent a clinical symptom of IgG4-related disease.

    DOI: 10.1111/ijd.12868

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  • Ectopic thyroid tissue in the adrenal gland: CT and MRI findings 査読

    A. Tada, T. Tanaka, A. Takamoto, H. Yanai, S. Sato, S. Kanazawa

    DIAGNOSTIC AND INTERVENTIONAL IMAGING97 ( 3 ) 371 - 373   2016年3月

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    記述言語:英語   出版者・発行元:ELSEVIER MASSON  

    DOI: 10.1016/j.diii.2015.06.025

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  • Actual Status of Involvement of Helicobacter pylori Infection That Developed Gastric Cancer from Group A of ABC (D) Stratification - Study of Early Gastric Cancer Cases That Underwent Endoscopic Submucosal Dissection 査読

    Ko Miura, Hiroyuki Okada, Yoshiyasu Kouno, Hiromitsu Kanzaki, Masaya Iwamuro, Keisuke Hori, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Hiroyuki Yanai

    DIGESTION94 ( 1 ) 17 - 23   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:KARGER  

    Background/Aims: Patients who are Helicobacter pylori antibody negative and have normal pepsinogen (PG) levels (group A of ABC (D) stratification) are considered unlikely to develop gastric cancer. This study aimed to clarify the involvement (uninfection, present infection or previous infection) of H. pylori in group A patients with early gastric cancer who underwent endoscopic submucosal dissection (ESD) by examining their background gastric mucosa endoscopically and histologically. Methods: This study included 166 patients with gastric cancer who were treated by ESD. Patients were classified according to PG levels and H. pylori antibody titers. Three biopsies (greater curvature of the antrum, lesser curvature of the middle corpus and greater curvature of the middle corpus) from group A were histologically analyzed and compared with those of groups B, C, D and after eradication). Results: In group A (34 patients), 32 patients had endoscopic atrophy (group A'). Histological neutrophil activity, chronic inflammation and atrophy scores were lower in group A' than in other groups. Group A' scores were similar to those of the after eradication group. Conclusion: Most of the group A patients with early gastric cancer were not uninfected with H. pylori, but had previous infections, thus carrying carcinogenic risk. (C) 2016 S. Karger AG, Basel

    DOI: 10.1159/000446771

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  • Peutz-Jeghers syndromeに合併した子宮頸部最小偏倚型粘液性腺癌の二例 査読

    田中梓菜, 中西美恵, 澤田麻里, 永井あや, 柳井広之, 早瀬良二

    日本婦人科腫瘍学会雑誌34 ( 2 ) 134 - 143   2016年

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    記述言語:日本語  

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  • 高アンドロゲン/高エストロゲン血症およびpseudo-Meigs症候群を呈し,性索間質腫瘍が疑われた卵巣類内膜腺癌の一例 査読

    田中梓菜, 関 典子, 西田 傑, 春間朋子, 小川千加子, 楠本知行, 中村圭一郎, 増山 寿, 柳井広之, 平松祐司

    日本婦人科腫瘍学会雑誌34 ( 2 ) 112 - 118   2016年

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    記述言語:日本語  

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  • 耳下腺に発生した mammary analogue secretory carcinoma の 1 例 ― 形態的特徴と鑑別診断を中心に― 査読

    那須 篤子, 畠 榮, 藤田 勝, 山内 豊子, 中村 聡子, 田中 健大, 市村 浩一, 柳井 広之

    日本臨床細胞学会雑誌55 ( 2 ) 112 - 118   2016年

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  • 前眼房水に浸潤した節外性 NK/T 細胞リンパ腫鼻型の 1 例 査読

    那須 篤子, 市村 浩一, 畠 榮, 柳井 広之, 藤田 勝, 濵田 香菜, 田中 健大, 吉野 正

    日本臨床細胞学会雑誌55 ( 2 ) 89 - 93   2016年

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  • 小児の頭蓋内髄膜腫術後肺転移の一例

    今井 みどり, 濱田 香菜, 那須 篤子, 井上 博文, 藤田 勝, 田中 健大, 柳井 広之

    岡山県臨床細胞学会誌35   30 - 33   2016年

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  • 涙腺から発生したと考えられた導管癌の1例 査読

    田中 顕之, 田中 健大, 松本 洋, 柳井 広之, 吉野 正

    診断病理33 ( 3 ) 254 - 258   2016年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Feasibility of Neoadjuvant Ad-REIC Gene Therapy in Patients with High-Risk Localized Prostate Cancer Undergoing Radical Prostatectomy 査読

    Hiromi Kumon, Katsumi Sasaki, Yuichi Ariyoshi, Takuya Sadahira, Motoo Araki, Shin Ebara, Hiroyuki Yanai, Masami Watanabe, Yasutomo Nasu

    CTS-CLINICAL AND TRANSLATIONAL SCIENCE8 ( 6 ) 837 - 840   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    In a phase I/IIa study of in situ gene therapy using an adenovirus vector carrying the human REIC/Dkk-3 gene (Ad-REIC), we assessed the inhibitory effects of cancer recurrence after radical prostatectomy (RP), in patients with high risk localized prostate cancer (PCa). After completing the therapeutic interventions with initially planned three escalating doses of 1.0 x 10(10), 1.0 x 10(11), and 1.0 x 10(12) viral particles (VP) in 1.0-1.2 mL (n = 3, 3, and 6), an additional higher dose of 3.0 x 10(12) VP in 3.6 mL (n = 6) was further studied. Patients with recurrence probability of 35% or more within 5 years after RP as calculated by Kattan's nomogram, were enrolled. They received two ultrasound-guided intratumoral injections at 2-week intervals, followed by RP 6 weeks after the second injection. Based on the findings of MRI and biopsy mapping, as a rule, one track injection to the most prominent cancer area was given to initial 12 patients and 3 track injections to multiple cancer areas in additional 6 patients. As compared to the former group, biochemical recurrence-free survival of the latter showed a significantly favorable outcome. Neoadjuvant Ad-REIC, mediating simultaneous induction of cancer selective apoptosis and augmentation of antitumor immunity, is a feasible approach in preventing cancer recurrence after RP. (199)

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  • エトポシドとシスプラチンの併用療法(EP療法)が著効し組織学的CRが得られた肝原発小細胞癌の1切除例

    秋元 悠, 堤 康一郎, 加藤 博也, 幡 英典, 榮 浩行, 内田 大輔, 友田 健, 松本 和幸, 野間 康宏, 山本 直樹, 堀口 繁, 原田 亮, 岡田 裕之, 柳井 広之, 八木 孝仁, 山本 和秀

    日本消化器病学会雑誌112 ( 11 ) 2024 - 2034   2015年11月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

    52歳女性。主訴は右上腹部痛。巨大な肝腫瘤と多発性肝腫瘤、胆嚢壁肥厚を認め、EUS-FNAにて小細胞癌と診断。エトポシド、シスプラチン併用療法が著効したため、根治目的に肝中央二区域・胆管切除術、胆嚢摘出術施行。病理では泡沫細胞の集簇を認め、viableな腫瘍細胞は認めなかった。画像、病理所見より、肝原発小細胞癌と最終診断した。化学療法著効後に根治切除でき、組織学的CRが得られた貴重な1例である。(著者抄録)

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  • [Radical surgery after successful chemotherapy in a case of primary small cell carcinoma of the liver]. 査読

    Yutaka Akimoto, Koichiro Tsutsumi, Hironari Kato, Hidenori Hata, Hiroyuki Sakae, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Yasuhiro Noma, Naoki Yamamoto, Shigeru Horiguchi, Ryo Harada, Hiroyuki Okada, Hiroyuki Yanai, Takahito Yagi, Kazuhide Yamamoto

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology112 ( 11 ) 2024 - 34   2015年11月

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    記述言語:日本語  

    A 52-year-old woman was admitted to our hospital with right upper quadrant pain with gallbladder wall thickening and multiple liver tumors. Endoscopic ultrasound-guided biopsy revealed small cell carcinomas of both the gallbladder and liver. After 10 cycles of chemotherapy with etoposide and cisplatin, marked shrinkage of the tumors was evident on computed tomography. The patient subsequently underwent hepatectomy and resection of the extrahepatic bile duct and gallbladder with curative intent. Although no viable tumor cells were found in the resected specimens, we confirmed phagocytosis of tumor cells killed by chemotherapy in the resected liver specimen. Therefore, we suspected that the patient had primary small cell carcinoma of the liver that had been successfully treated. This is a rare case of primary small cell carcinoma of the liver that showed pathological complete response to chemotherapy with etoposide and cisplatin.

    DOI: 10.11405/nisshoshi.112.2024

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  • Diagnostic value of Thallium-201 scintigraphy in differentiating malignant bone tumors from benign bone lesions 査読

    Ryota Inai, Takayoshi Shinya, Akihiro Tada, Shuhei Sato, Tomohiro Fujiwara, Ken Takeda, Toshiyuki Kunisada, Hiroyuki Yanai, Toshifumi Ozaki, Susumu Kanazawa

    ANNALS OF NUCLEAR MEDICINE29 ( 8 ) 674 - 681   2015年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    This retrospective study aims to evaluate the diagnostic capacity of thallium-201 (201Tl) scintigraphy for differentiating malignant bone tumors from benign bone lesions.
    Between January 2006 and December 2012, 279 patients with bone lesions (51 malignant and 228 benign) underwent 201Tl scintigraphy before treatment. To evaluate 201Tl uptake, we investigated tumor-to-background contrast (TBC) as well as TBC washout rate (WR). The differences of TBC on early and delayed images and WR were estimated by the Mann-Whitney U test. Receiver operating characteristic (ROC) analyses were used to determine the cut-off TBC values for differentiating malignant bone tumors from benign bone lesions.
    There were statistically significant differences in median TBC between malignant tumors and benign lesions. These differences occurred for early imaging (1.57 vs. 0.09, p < 0.001) as well as for delayed imaging (0.83 vs. 0.07, p < 0.001). However, there was no statistical difference in WR between malignant tumors and benign lesions (44 vs. 43 %, NS). The chosen TBC cut-off value was 0.68 for early imaging and 0.38 for delayed imaging. Using these cut-off values, the prediction of malignancy had a 77 % sensitivity, 74 % specificity, and 75 % accuracy for early imaging and an 80 % sensitivity, 76 % specificity, and 77 % accuracy for delayed imaging.
    201Tl scintigraphy may have the ability to distinguish malignant bone tumors from benign bone lesions.

    DOI: 10.1007/s12149-015-0990-6

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  • Clinicopathological heterogeneity in ovarian clear cell adenocarcinoma: a study on individual therapy practice 査読

    Yuji Matsuo, Hironori Tashiro, Hiroyuki Yanai, Takuya Moriya, Hidetaka Katabuchi

    MEDICAL MOLECULAR MORPHOLOGY48 ( 3 ) 146 - 154   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER JAPAN KK  

    Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belong to a single category. We focused on CCAs combined with other histological types of EOAs; we re-evaluated the pathology of 46 CCAs and divided them into two subgroups: 35 CCAs alone (pure-type CCAs); and 11 CCAs with other histological types, endometrioid adenocarcinomas (EAs) or/and serous adenocarcinomas (SAs) (mixed-type CCAs). Immunohistochemical analysis for expression of ARID1A, p53, PTEN, Annexin 4, hepatocyte nuclear factor-1 beta (HNF-1 beta), and WT-1 was employed. We identified that patients with endometriosis were younger than those without endometriosis in pure-type CCAs (P < 0.005). In mixed-type CCAs, the immunohistochemical-staining patterns revealed internal transition of each histological component. In pure-type CCAs, expressions of ARID1A and p53 were mutually altered, and altered expression of p53 was associated with worse prognosis than that of ARID1A (P < 0.001). Our results provide evidence that CCAs would have clinicopathological heterogeneity, determining the patient's prognosis. Furthermore, immunohistochemical analysis may shed light on the selection of appropriate treatment, including chemotherapy.

    DOI: 10.1007/s00795-014-0090-z

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  • Both a visual and a semiquantitative analysis for differentiating benign from malignant chondrogenic bone tumors using Tc-99m (V) DMSA scintigraphy: a prospective study 査読

    Takayoshi Shinya, Shuhei Sato, Toshiyuki Kunisada, Ryota Inai, Hiroyuki Yanai, Toshifumi Ozaki, Susumu Kanazawa

    NUCLEAR MEDICINE COMMUNICATIONS36 ( 8 ) 802 - 807   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    ObjectiveThe aims of this prospective study were to assess the relationship between tumor aggressiveness and Tc-99m (V) dimercaptosuccinic acid (DMSA) uptake in chondrogenic bone tumors and the value of Tc-99m (V) DMSA scintigraphy for differentiating benign from malignant tumors.MethodsTwenty-four patients with chondrogenic tumors (19 benign and five malignant) underwent Tc-99m DMSA (V) scintigraphy. Radiopharmaceutical uptake was classified using a three-point scale to allow a visual-only analysis, and a tumor-to-background contrast (TBC) was computed using regions of interest to provide a semiquantitative analysis. Spearman's correlation coefficient was used to assess the correlation between tumor aggressiveness and TBC. The difference in TBC between benign and malignant tumors was analyzed with the Mann-Whitney U-test. An appropriate cutoff value of TBC was chosen for the diagnosis of malignancy of a tumor using receiver operating characteristic analysis.ResultsSix benign tumors showed negative uptake (uptake score 0), whereas 13 benign tumors showed positive uptake (n=10 uptake score 1; n=3 uptake score 2). All chondrosarcomas showed positive uptake (n=2 uptake score 1; n=3 uptake score 2). A significant correlation was found between tumor aggressiveness and TBC. A significant difference was seen in TBC between benign and malignant tumors. With the chosen cutoff value of TBC equal to 0.611, the sensitivity was 80.0%, specificity was 78.9%, the positive predictive value was 50.0%, and the negative predictive value was 93.8%.ConclusionTc-99m (V) DMSA scintigraphy may have the potential to improve diagnostic methods for detecting chondrosarcomas using visual and/or semiquantitative analyses.

    DOI: 10.1097/MNM.0000000000000328

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  • Simultaneous immunostaining with anti-S100P and anti-SV40 antibodies revealed the origin of BK virus-infected decoy cells in voided urine samples 査読

    S. Ariyasu, H. Yanai, M. Sato, Y. Shinno, K. Taniguchi, I. Yamadori, Y. Miki, Y. Sato, T. Yoshino, K. Takahashi

    CYTOPATHOLOGY26 ( 4 ) 250 - 255   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    BackgroundMethods for determining the origin of BK virus (BKV)-infected cells (decoy cells) in clinical urine samples have not been established although they could enhance the diagnosis of BKV infection in immunocompromised patients.
    MethodsWe performed simultaneous immunostaining with anti-S100P (a urothelial marker) and anti-SV40 antibodies in 66 clinical urine samples exhibiting SV40 positivity and a decoy-cell appearance on Papanicolaou staining. The clinical voided urine samples included seven cases of renal transplantation, 47 cases of cancer therapy and 12 cases of non-neoplastic disease. SurePath liquid-based cytology was used for the urine samples.
    ResultsBKV-infected cells were categorized as SV40(+)/S100P(+) and SV40 (+)/S100p(-). SV40(+)/S100P(-) cells were found in 55 cases (83.4%); nine cases (13.6%) carried both SV40(+)/S100P(-) and SV40(+)/S100P(+) cells. The former were identified as BKV infection in renal tubules and the latter in both the renal tubules and urothelial epithelia. The remaining two cases (3.0%) had only SV40(+)/S100P(+) cells of urothelial origin.
    ConclusionSimultaneous immunostaining with anti-S100P and anti-SV40 is a useful method for determining the origin of BKV-infected cells in clinical urine samples from immunocompromised patients such as renal transplantation recipients.

    DOI: 10.1111/cyt.12213

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  • A Paraganglioma in a Hypertensive Patient with Unilateral Renal Hypoplasia 査読

    Tomohiro Terasaka, Hideharu Hagiya, Kosuke Kimura, Takahiro Nada, Eri Nakamura, Yoshihisa Hanayama, Hitoshi Sugiyama, Yasuyuki Kobayashi, Hiroyuki Yanai, Fumio Otsuka

    ACTA MEDICA OKAYAMA69 ( 2 ) 119 - 122   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia.

    DOI: 10.18926/AMO/53341

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  • Ad-REIC gene therapy: Promising results in a patient with metastatic CRPC following chemotherapy 査読

    Hiromi Kumon, Katsumi Sasaki, Yuichi Ariyoshi, Takuya Sadahira, Shin Ebara, Takao Hiraki, Susumu Kanazawa, Hiroyuki Yanai, Masami Watanabe, Yasutomo Nasu

    Clinical Medicine Insights: Oncology9 ( 9 ) 31 - 38   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Libertas Academica Ltd.  

    A 63-year-old man with metastatic castration-resistant prostate cancer (CRPC) was successfully treated for two years with in situ gene therapy using an adenovirus vector carrying the human REIC/Dkk‑3 gene (Ad-REIC), following chemotherapy. Ad-REIC mediates simultaneous induc-tion of cancer-selective apoptosis and augmentation of antitumor immunity, and a Phase I/IIa clinical study on Ad-REIC has been conducted at Okayama University Hospital since January 2011. At the time of enrollment in December 2012, the patient presented with rapid progression of lymph node (LN) metastases. Two scheduled Ad-REIC injections and 10 additional Ad-REIC injections into metastatic pelvic and para-aortic LNs under CT guidance, with an average four weeks’ interval, exhibited the potent direct and indirect effects of Ad-REIC as a therapeutic cancer vaccine. During the next 12 months, three additional injections into para-aortic LNs showing regrowth achieved adequate control of all metastatic LNs with prostate-specific antigen (PSA) decline, without any particular adverse events.

    DOI: 10.4137/CMO.S23252

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  • 心室細動を初発症状とした心アミロイドーシスの1例(共著)

    小野 環, 森田 宏, 木村朋生, 時岡浩二, 中川晃志, 西井伸洋, 永瀬 聡, 中村一文, 伊藤 浩, 田中健大, 柳井広之, 安藤 翠, 由谷親夫

    心臓47 ( suppl-1 ) 33 - 37   2015年

  • Inter and intratumoral heterogeneity in ovarian clear cell adenocarcinoma: A study forward individual ovarian cancer therapy practice.

    Y.Matsuo, H.Tashiro, H.Yanai, T.Moriya, H.Katabuchi

    Medical Molecular Morphology   2015年

  • Fatal glioblastoma after Gamma Knife radiosurgery for arteriovenous malformation in a child.(共著) 査読

    Yoshida K, Ichikawa T, Kurozumi K, Yanai H, Onoda K, Date I

    Journal of Clinical Neuroscience21 ( 8 ) 1453 - 1455   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jocn.2013.10.039

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  • 直腸癌術後尿管再発の1例

    松本 聖, 稲田 涼, 近藤喜太, 母里淑子, 岸本浩行, 江原 伸, 戸田博子, 柳井広之, 永坂岳司, 藤原俊義

    癌の臨床60 ( 5 ) 549 - 554   2014年

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  • Nestin is a wide-spectrum abluminal cell marker of salivary gland tumors 査読

    Hiroyuki Yanai, Yasuharu Sato, Hitoshi Nagatsuka, Tadashi Yoshino

    PATHOLOGY INTERNATIONAL63 ( 10 ) 496 - 501   2013年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Nestin is an intermediate filament that was first identified in neural progenitor cells. It is expressed in various cell types in the nervous system as well as in other systems. In the present study, we investigated nestin expression in non-neoplastic salivary gland tissue and in salivary gland tumors. In non-neoplastic salivary glands, nestin expression was observed in only a few abluminal cells. In contrast, diffuse nestin staining was observed in the abluminal cells of pleomorphic adenoma (11 of 11 cases), basal cell adenoma (7 of 7 cases), and epithelial-myoepithelial carcinoma (2 of 2 cases). The stromal cells in basal cell adenoma also expressed nestin. In adenoid cystic carcinoma (6 of 7 cases) and polymorphous low-grade adenocarcinoma (3 of 3 cases), nestin positive cells were observed focally. Nestin was not detected in Warthin tumor (6 cases), classical acinic cell carcinoma (2 cases), mucoepidermoid carcinoma (5 cases), or salivary duct carcinoma (4 cases). Because the nestin expression pattern in each histological salivary gland tumor type is unique, nestin could be a very useful abluminal cell marker for the diagnosis of salivary gland tumors.

    DOI: 10.1111/pin.12103

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  • Predictive factors for acute and late urinary toxicity after permanent interstitial brachytherapy in Japanese patients 査読

    Ryuta Tanimoto, Kensuke Bekku, Norihisa Katayama, Yasuyuki Kobayashi, Shin Ebara, Motoo Araki, Mitsuhiro Takemoto, Hiroyuki Yanai, Yasutomo Nasu, Hiromi Kumon

    International Journal of Urology20 ( 8 ) 812 - 817   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To describe the frequency of and to determine predictive factors associated with Radiation Therapy Oncology Group urinary toxicity in prostate brachytherapy patients. Methods: From January 2004 to April 2011, 466 consecutive Japanese patients underwent permanent iodine-125-seed brachytherapy (median follow up 48 months). International Prostate Symptom Score and Radiation Therapy Oncology Group toxicity data were prospectively collected. Prostate volume, International Prostate Symptom Score before and after brachytherapy, and postimplant analysis were examined for an association with urinary toxicity, defined as Radiation Therapy Oncology Group urinary toxicity of Grade1 or higher. Logistic regression analysis was used to examine the factors associated with urinary toxicity. Results: The rate of Radiation Therapy Oncology Group urinary toxicity grade1 or higher at 1, 6, 12, 24, 36 and 48 months was 67%, 40%, 21%, 31%, 27% and 28%, respectively. Grade2 or higher urinary toxicity was less than 1% at each time-point. International Prostate Symptom Score was highest at 3 months and returned to normal 12 months after brachytherapy. On univariate analysis, patients with a larger prostate size, greater baseline International Prostate Symptom Score, higher prostate V100, higher prostate V150, higher prostate D90 and a greater number of seeds had more acute urinary toxicities at 1 month and 12 months after brachytherapy. On multivariate analysis, significant predictors for urinary toxicity at 1 month and 12 months were a greater baseline International Prostate Symptom Score and prostate V100. Conclusions: Most urinary symptoms are tolerated and resolved within 12 months after prostate brachytherapy. Acute and late urinary toxicity after brachytherapy is strongly related to the baseline International Prostate Symptom Score and prostate V100. © 2013 The Japanese Urological Association.

    DOI: 10.1111/iju.12050

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  • Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix 査読

    Naoto Kuroda, Yukari Wada, Kaori Inoue, Masahiko Ohara, Keiko Mizuno, Makoto Toi, Azusa Tanaka, Yoji Wani, Hiroyuki Yanai

    DIAGNOSTIC CYTOPATHOLOGY41 ( 7 ) 636 - 639   2013年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59-year-old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor. Diagn. Cytopathol. 2013. (c) 2011 Wiley Periodicals, Inc.

    DOI: 10.1002/dc.21834

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  • Clinicopathologic analysis of IgG4-related skin disease 査読

    Yasuharu Sato, Mai Takeuchi, Katsuyoshi Takata, Kyotaro Ohno, Noriko Iwaki, Yorihisa Orita, Naoe Goto, Akira I. Hida, Toshiyuki Iwamoto, Naoko Asano, Toshihiro Ito, Hiroyuki Hanakawa, Hiroyuki Yanai, Tadashi Yoshino

    Modern Pathology26 ( 4 ) 523 - 532   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    IgG4-related disease is a recently recognized systemic syndrome characterized by mass-forming lesions with lymphoplasmacytic infiltration, increase in the number of IgG4 + cells in affected tissues and elevation of serum IgG4 levels. In 2009, we were the first to report skin lesions in patients with IgG4-related disease, but no large case series has been reported and clinicopathological findings remain unclear. To clarify these features, we herein report 10 patients (9 men and 1 woman
    median age, 64 years
    age range, 46-81 years) with IgG4-related skin disease. All patients had erythematous and itchy plaques or subcutaneous nodules on the skin of the head and neck, particularly in the periauricular, cheek, and mandible regions, except for one patient, whose forearm and waist skin were affected. In addition, eight patients had extracutaneous lesions: these were found on the lymph nodes in six patients, the lacrimal glands in three patients, the parotid glands in three patients, and the kidney in one patient. Histologically examined extracutaneous lesions were consistent with IgG4-related disease
    five of six lymph node lesions showed progressively transformed germinal centers-type IgG4-related lymphadenopathy. Cases of IgG4-related skin disease were classified into two histological patterns: those exhibiting a nodular dermatitis pattern and those with a subcutaneous nodule pattern. The infiltrate was rich in plasma cells, small lymphocytes, and eosinophils
    the majority of the plasma cells were IgG4 +. The IgG4 + cell count was 49-396 per high-power field (mean±s.d., 172±129), with an IgG4 +/IgG + cell ratio ranging from 62 to 92%. Serum IgG4 levels were elevated in all examined patients. In conclusion, patients with IgG4-related skin disease had uniform clinicopathology. Lesions were frequently present on the skin of the periauricular, cheek, and mandible regions, and were frequently accompanied by IgG4-related lymphadenopathy. © 2013 USCAP, Inc. All rights reserved.

    DOI: 10.1038/modpathol.2012.196

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  • A case of synovial sarcoma with brain metastasis treated with surgical resection and stereotactic radiosurgery 査読

    Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Hiroyuki Yanai, Toshiyuki Kunisada, Toshifumi Ozaki, Isao Date

    Neurological Surgery41 ( 3 ) 255 - 262   2013年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Synovial sarcomas compromise between 5 to 10% of all soft tissue sarcomas in adults. Synovial sarcoma commonly occurs in the vicinity of the large joints and cranial metastasis is rare. Here, we describe a case with intracranial metastases of a synovial sarcoma A 41-year-old woman was admitted to our department with sensory aphasia. She had a history of a left inguinal synovial sarcoma and underwent surgery and chemotherapy for primary and metastatic lesions Head MRI revealed three gadolinium-enhancing lesions in the left frontal, parietal and parietotemporal lobe Gross total resection was achieved in the left parietotemporal lesion and pathological diagnosis was synovial sarcoma. Two weeks after surgery, she received cyber-knife radiosurgery and her neurological deficit was almost completely resolved Intracranial metastatic synovial sarcoma is rare. Surgical resection and stereotaxic radiosurgery was very effective in the present case.

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  • 甲状腺乳頭癌と結腸癌の重複癌が頸部リンパ節に同時転移した1例

    野村長久, 三好和也, 西江 学, 岩川和秀, 柳井広之, 園部 宏, 田中克浩

    日本内分泌・甲状腺外科学会雑誌30 ( 3 ) 226 - 231   2013年

  • 1型神経線維腫症の異型神経線維腫を背景に発生した低悪性度悪性末梢神経鞘腫瘍の1例

    田中梓菜, 黒田直人, 柳井広之, 岩田 純

    診断病理30 ( 1 ) 19 - 22   2013年

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  • 当院で治療した子宮体癌患者319症例の疫学的調査 査読

    春間朋子, 中村圭一郎, 福島千加子, 楠本知行, 関 典子, 柳井広之, 平松祐司

    日本婦人科腫瘍学会雑誌31 ( 4 ) 137 - 142   2013年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 膣転移で発見された悪性傍神経節種の1例

    多賀茂樹, 早瀬良二, 柳井広之

    日本婦人科腫瘍学会雑誌31 ( 1 ) 14 - 17   2013年

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  • 乳頭状卵管過形成を伴う卵巣漿液性境界悪性腫瘍の一例

    黒田直人, 田中梓菜, 柳井広之

    日本婦人科病理学会誌4 ( 2 ) 97 - 99   2013年

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  • 胃底腺型胃癌の1例 査読

    田中健大, 市村浩一, 柳井広之, 吉野 正

    診断病理30 ( 1 ) 62 - 65   2013年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 外科的摘出および定位放射線治療が有用であった転移性滑膜肉腫の1例

    大谷 理浩, 市川 智継, 黒住 和彦, 柳井 広之, 国定 俊之, 尾崎 敏文, 伊達 勲

    Neurological Surgery41 ( 3 ) 255 - 262   2013年

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  • 術後急速な増悪を示した原発性胆嚢絨毛癌の1例

    徳永尚之, 稲垣 優, 木村裕司, 北田浩二, 岩垣博巳, 柳井広之

    日本消化器外科学会雑誌46 ( 4 ) 268 - 274   2013年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5833/jjgs.2012.0195

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  • Primary signet-ring cell/histiocytoid carcinoma of the axilla expressing human epidermal growth factor receptor 2 査読

    Tomoko Miyake, Osamu Yamasaki, Maho Sugiu, Toshihisa Hamada, Masaki Otsuka, Hiroyuki Yanai, Yoshiko Morishita, Keiji Iwatsuki

    JOURNAL OF DERMATOLOGY39 ( 12 ) 1038 - 1040   2012年12月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/j.1346-8138.2012.01561.x

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  • Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma 査読

    Takehiro Tanaka, Atsushi Fujimura, Koichi Ichimura, Hiroyuki Yanai, Yasuharu Sato, Katsuyohi Takata, Hiroyuki Okada, Seiji Kawano, Shunsuke Tanabe, Tadashi Yoshino

    WORLD JOURNAL OF GASTROENTEROLOGY18 ( 43 ) 6263 - 6268   2012年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BAISHIDENG PUBL GRP CO LTD  

    AIM: To compare the clinicopathological characteristics of human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative Barrett's adenocarcinoma in Japan.
    METHODS: We performed immunohistochemical analysis of HER2 in 30 samples taken from patients with Barrett's adenocarcinoma and dual color in situ hybridization in cases showing 2+ reactions. We compared the clinicopathological characteristics of HER2-positive and HER2-negative patients.
    RESULTS: HER2 positivity was identified in 8 (27%) carcinoma samples. We found that HER2 expression was associated with p53 overexpression (100% vs 52.6% in pT1 tumor; 100% vs 54.5% in all stage tumor, P < 0.05) and protruding lesions at the early disease stage. There was no association between the mucin phenotype of the carcinomas and prognosis. HER2 expression and low clinical stage were unexpectedly different between Barrett's adenocarcinoma patients and gastric cancer patients, but the macroscopic features may be associated with earlier diagnosis in these patients.
    CONCLUSION: Our results suggest that HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage. (C) 2012 Baishideng. All rights reserved.

    DOI: 10.3748/wjg.v18.i43.6263

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  • Carcinosarcoma of the Gallbladder Manifesting as Cholangitis Due to Hemobilia 査読

    Hiroshi Sadamori, Hiroyasu Fujiwara, Takehiro Tanaka, Hiroyuki Yanai, Daisuke Satoh, Takahito Yagi, Toshiyoshi Fujiwara

    JOURNAL OF GASTROINTESTINAL SURGERY16 ( 6 ) 1278 - 1281   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Carcinosarcomas of the gallbladder are rare tumors that are characterized by malignant epithelial and mesenchymal components, and preoperative diagnosis of carcinosarcoma of the gallbladder remains difficult.
    We recently encountered a case of carcinosarcoma of the gallbladder with osteoid and chondroid differentiation, manifesting as cholangitis due to hemobilia.
    Preoperative computed tomography and magnetic resonance imaging indicated the cause of cholangitis and provided qualitative information regarding the two components of the tumor.

    DOI: 10.1007/s11605-012-1836-3

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  • The clinical impact of pathological review on selection the treatment modality for localized prostate cancer in candidates for brachytherapy monotherapy 査読

    Ryo Kishimoto, Takashi Saika, Kensuke Bekku, Hiroyuki Nose, Fernando Abarzua, Yasuyuki Kobayashi, Motoo Araki, Hiroyuki Yanai, Yasutomo Nasu, Hiromi Kumon

    WORLD JOURNAL OF UROLOGY30 ( 3 ) 375 - 378   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    To evaluate the impact of pathological review by pathologist with genitourinary expertise (PGU) on treatment modality of localized prostate cancer, we analyzed Gleason grade (GG) migration and the final treatment decision in a cohort of patients designated for permanent prostate brachytherapy (PPB).
    From February 2005 to July 2010, a total of 247 patients with localized prostate cancer diagnosed by local community hospitals were referred to our hospital for PPB monotheray. All pathologic slides of prostate biopsies were reviewed by a single PGU. Patients ultimately selected their treatment modality from our recommendations based on the review. Indication for PPB monotherapy was the NCCN classification of patients as good or intermediate risk. In addition, patient with Primary GG 4 was regarded as unadapted case.
    Six cases were reinterpreted as no cancer (2.4%). GG change occurred in 94 cases (38.1%) of which 77 (81.9%) were upgraded and 17 (18.1%) downgraded. Of the total 247 patients, 86 (34.8%) changed therapies and 30 (12.1%) did so based on the pathologic slide review.
    Pathological review of biopsy specimens is mandatory for the determination of treatment modality especially in candidates for monotherapy of permanent prostate brachytherapy.

    DOI: 10.1007/s00345-011-0738-4

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  • Primary Gleason grade 4 impact on biochemical recurrence after permanent interstitial brachytherapy in Japanese patients with low- or intermediate-risk prostate cancer

    Tatsuya Uesugi, Takashi Saika, Kohei Edamura, Hiroyuki Nose, Makoto Kobuke, Shin Ebara, Fernand Abarzua, Norihisa Katayama, Hiroyuki Yanai, Yasutomo Nasu, Hiromi Kumon

    International Journal of Radiation Oncology Biology Physics82 ( 2 ) e219 - e223   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Purpose: To reveal a predictive factor for biochemical recurrence (BCR) after permanent prostate brachytherapy (PPB) using iodine-125 seed implantation in patients with localized prostate cancer classified as low or intermediate risk based on National Comprehensive Cancer Network (NCCN) guidelines. Methods and Materials: From January 2004 to December 2009, 414 consecutive Japanese patients with clinically localized prostate cancer classified as low or intermediate risk based on the NCCN guidelines were treated with PPB. The clinical factors including pathological data reviewed by a central pathologist and follow-up data were prospectively collected. Kaplan-Meier and Cox regression analyses were used to assess the factors associated with BCR. Results: Median follow-up was 36.5 months. The 2-, 3-, 4-, and 5-year BCR-free rates using the Phoenix definition were 98.3%, 96.0%, 91.6%, and 87.0%, respectively. On univariate analysis, the Gleason score, especially primary Gleason grade 4 in biopsy specimens, was a strong predicting factor (p &lt
    0.0001), while age, initial prostate-specific antigen (PSA) level, T stage, and minimal dose delivered to 90% of the prostate volume (D90) were insignificant. Multivariate analysis indicated that a primary Gleason grade 4 was the most powerful prognostic factor associated with BCR (hazard ratio = 6.576, 95% confidence interval, 2.597-16.468, p &lt
    0.0001). Conclusions: A primary Gleason grade 4 carried a worse BCR prognosis than the primary grade 3 in patients treated with PPB. Therefore, the indication for PPB in patients with a Gleason sum of 4 + 3 deserves careful and thoughtful consideration. © 2012 Elsevier Inc.

    DOI: 10.1016/j.ijrobp.2011.04.018

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  • Prostatic stromal tumor of uncertain malignant potential (STUMP) with unrecognized growth pattern 査読

    Soichiro Fushimi, Tetsuya Ogino, Ken Aoki, Junya Itakura, Toshihiro Ito, Tadashi Oeda, Hiroyuki Yanai, Akihiro Matsukawa

    PATHOLOGY INTERNATIONAL62 ( 1 ) 69 - 71   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/j.1440-1827.2011.02741.x

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  • 心臓原発malignant fibrous histiocytoma(MFH)の十二指腸転移の1例

    沼田紀史, 中川昌浩, 岡本良一, 東玲治, 平尾謙, 小川恒由, 大江啓常, 植木亨, 高田晋一, 松浦博夫, 柳井広之, 水野元夫

    胃と腸   2012年

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  • 卵巣明細胞腺癌Ia期に対する病理組織学的観点からの考察

    松尾勇児, 宮原 陽, 本田律生, 大竹秀幸, 田代浩徳, 柳井広之, 森谷卓也, 片渕秀隆

    日本婦人科腫瘍学会雑誌   2012年

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  • 小細胞癌成分を含む食道癌肉腫の1切除例

    田辺俊介, 白川靖博, 前田直見, 大原利章, 野間和広, 櫻間教文, 柳井広之, 山辻知樹, 猶本良夫, 藤原俊義

    岡山医学会雑誌   2012年

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  • Thallium-201 Scintigraphy Is an Effective Diagnostic Modality to Distinguish Malignant From Benign Soft-Tissue Tumors 査読

    Naoaki Kawakami, Toshiyuki Kunisada, Shuhei Sato, Yuki Morimoto, Masato Tanaka, Tsuyoshi Sasaki, Shinsuke Sugihara, Hiroyuki Yanai, Susumu Kanazawa, Toshifumi Ozaki

    CLINICAL NUCLEAR MEDICINE36 ( 11 ) 982 - 986   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background: The aim of this study is to evaluate whether thallium-201 (201-Tl) scintigraphy can differentiate malignant from benign soft-tissue tumors.
    Methods: Between April 1995 and December 2005, 192 patients with soft-tissue tumors (85 malignant and 107 benign) underwent 201-Tl scintigraphy before treatment. Isotope uptake was used as a proxy for tumor-to-background ratio (TBR). The accuracy of TBR on early and delayed imaging was evaluated using the Mann-Whitney U and chi(2) tests.
    Results: There was a statistically significant difference in mean TBR on early and delayed imaging of malignant and benign soft-tissue tumors (124% +/- 109% vs. 22% +/- 42%, and 82% +/- 83% vs. 12% +/- 25%, P < 0.0001). A TBR cutoff of 20% indicated the probability of malignancy on early and delayed imaging (82% sensitivity and 77% specificity; 82% sensitivity and 84% specificity, P < 0.0001). Well-differentiated liposarcomas showed low isotope accumulation, while pigmented villonodular synovitis and giant cell tumors of the tendon sheath showed high isotope accumulation.
    Conclusions: Thallium-201 scintigraphy can distinguish malignant from benign tumors with relatively high accuracy. With the exception of low grade liposarcomas and locally aggressive benign tumors, 201-Tl scintigraphy may be an effective diagnostic modality to differentiate malignant from benign soft-tissue tumors.

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  • Association between the expression pattern of p16, pRb and p53 and the response to intravesical bacillus Calmette-Guerin therapy in patients with urothelial carcinoma in situ of the urinary bladder 査読

    Masakazu Sato, Hiroyuki Yanai, Toshiaki Morito, Wakako Oda, Yoko Shin-no, Ichiro Yamadori, Tomoyasu Tshushima, Tadashi Yoshino

    PATHOLOGY INTERNATIONAL61 ( 8 ) 456 - 460   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    There is limited data regarding the association between the expression of cell cycle-regulating molecules and the response of patients with urothelial carcinoma in situ (CIS) to bacillus Calmette-Guerin (BCG) therapy. To examine the relationship between p16, pRb and p53 expression in bladder CIS and patient response to initial BCG therapy, we performed immunohistochemical studies for 27 patients with bladder CIS. Overexpression of p16, pRb, and p53 was observed in 37%, 41%, and 48% of patients, respectively. Initial BCG therapy was effective in 21 patients (78%). Coexistence of papillary urothelial carcinoma, depth (pTa or pT1) and grade of coexisting papillary carcinoma did not affect the response to BCG therapy. pRb overexpression had a significant relationship to poor response to BCG therapy (P = 0.027). The results of this study indicate that overexpression of pRb in bladder CIS predicts poor response of intravesical BCG instillation and status of p16 and p53 may not be predictive of initial BCG failure.

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  • Primary Germinoma in the Medulla Oblongata-Case Report

    Takao Yasuhara, Tomotsugu Ichikawa, Yasuyuki Miyoshi, Kazuhiko Kurozumi, Tomoko Maruo, Hiroyuki Yanai, Isao Date

    NEUROLOGIA MEDICO-CHIRURGICA51 ( 4 ) 326 - 329   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    A 27-year-old woman presented with a case of primary medulla oblongata germinoma manifesting as sleep apnea, aspiration pneumonia, and left hemiparesis. Magnetic resonance (MR) imaging revealed a dorsal mass in the medulla oblongata with heterogeneous enhancement by gadolinium (Gd). Emergent biopsy and foramen magnum decompression with C1 laminectomy were performed because of rapid worsening of her symptoms. The histological diagnosis was germinoma. Subsequently she received chemoradiation therapy with subsequent amelioration of her neurological deficits and disappearance of enhancement on MR imaging with Gd. Primary medulla oblongata germinoma is rare and difficult to diagnose preoperatively. However, correct diagnosis and subsequent adequate chemoradiation therapy is possible by understanding the common characteristics of the disease. Germinoma should be included in the differential diagnosis of midline medullary lesion in young patients, and biopsy should be considered.

    DOI: 10.2176/nmc.51.326

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  • Long-Term Effect of External Beam Radiotherapy of Optic Disc Hemangioma in a Patient with von Hippel-Lindau Disease 査読

    Toshihiko Matsuo, Kengo Himei, Kouichi Ichimura, Hiroyuki Yanai, Soichiro Nose, Tetsushige Mimura, Yasuyuki Miyoshi, Tomoyasu Tsushima

    ACTA MEDICA OKAYAMA65 ( 2 ) 135 - 141   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with noradrenal in-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Arg167Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was adminisitered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cerebellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.

    DOI: 10.18926/AMO/45273

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  • 性索間質性腫瘍(分類不能型)の1例

    乗金精一郎, 上者郁夫, 笹井信也, 井田健太郎, 加地充昌, 柳井広之, 金澤 右

    臨床放射線56 ( 13 ) 1855 - 1859   2011年

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  • 耳下腺上皮筋上皮癌の一例

    那須篤子, 井上博文, 藤田 勝, 濱田香菜, 松岡博美, 今井みどり, 田中健大, 市村浩一, 柳井広之, 吉野 正

    日本臨床細胞学会岡山支部会誌30   40 - 42   2011年

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  • 乳腺原発腺様嚢胞癌の一例 細胞像の多彩性について

    今井みどり, 濱田香菜, 那須篤子, 井上博文, 松岡博美, 藤田 勝, 大森昌子, 田中健大, 市村浩一, 柳井広之, 吉野 正

    日本臨床細胞学会岡山支部会誌30 ( 34 ) 35   2011年

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  • 放射線療法が奏効した,H. pylori陰性胃MALTリンパ腫の1例

    胃と腸46 ( 9 ) 1300 - 1303   2011年

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  • 神経内分泌分化した汗腺癌の1例

    池田佳寿子, 大塚正樹, 山崎修, 岩月啓氏, 岩谷佳代子, 柳井広之, 森下佳子

    Skin Cancer26 ( 2 ) 153 - 156   2011年

  • Uterine leiomyosarcoma arising in leiomyoma: Clinicopathological study of four cases and literature review

    Hiroyuki Yanai, Yoji Wani, Kenji Notohara, Shin-ichi Takada, Tadashi Yoshino

    PATHOLOGY INTERNATIONAL60 ( 7 ) 506 - 509   2010年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    In this study we examined four cases of leiomyosarcoma (LMS) arising in leiomyoma (LM). The patients ranged from 40 to 64 years old. Symptoms were unspecific and preoperative diagnosis of LMS had not been made. Size of the tumors ranged from 4 cm to 20.5 cm. All patients were in stage I and no patients developed recurrent disease. Histologically, the LMS component showed moderate to severe cytological atypia and an increased mitotic count in all cases. Tumor cell necrosis in the LMS was seen in three cases. Associated LM component was cellular in one case. The LMS component showed p53 expression in three of four cases and p16 expression was seen in two cases. The LM component lacked p53 expression in all cases and demonstrated p16 expression in two cases, including one case of cellular LM. In all cases, Ki-67-positive cells were less than 5% in the LM component and more than 25-30% in the LMS component. This study reveals that: (i) malignant transformation can occur even in relatively small LM; (ii) patients with LMS with an LM component have a favorable prognosis; and (iii) immunohistochemical examination of p53, p16 and Ki-67 is useful for identification of malignant focus.

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  • α-fetoprotein-producing endometrial adenocarcinoma without an obvious hepatoid component 査読

    Junichi Kodama, Noriko Seki, Hiroyuki Yanai, Tomoyuki Kusumoto, Keiichiro Nakamura, Atsushi Hongo, Yuji Hiramatsu

    Oncology Letters1 ( 2 ) 243 - 245   2010年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Endometrial carcinomas producing α-fetoprotein (AFP) are extremely rare. We report a case of AFP-producing, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. A 59-year-old multiparous woman presented with abdominal swelling. The serum level of AFP was 1292.8 ng/ml. Magnetic resonance images of the pelvis showed a markedly enlarged uterus, with a tumor growing exophytically within the endometrial cavity. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. The histopathological examination demonstrated a Stage IIA, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. The endometrioid adenocarcinoma cells were partly positive for AFP immunoreactivity. The patient received adjuvant chemotherapy and was disease-free 60 months after the operation. This case confirms the existence of AFP-producing endometrioid adenocarcinomas without hepatoid features.

    DOI: 10.3892/ol_00000043

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  • Frequent downregulation or loss of CD79a expression in plasma cell myelomas: potential clue for diagnosis. 査読 国際誌

    Takehiro Tanaka, Kouichi Ichimura, Yasuharu Sato, Katsuyoshi Takata, Toshiaki Morito, Maiko Tamura, Eisaku Kondo, Nobuya Ohara, Hiroyuki Yanai, Masaharu Sakai, Satoru Takahashi, Tadashi Yoshino

    Pathology international59 ( 11 ) 804 - 8   2009年11月

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    記述言語:英語  

    Plasma cell myeloma is a frequent hematogeneous disorder that occurs mainly in older people. Not only bone marrow smears but also clots and/or biopsied specimens are often taken for confirmation of pathological diagnosis. Some specimens show sheet-like plasma cell proliferation associated with immunoglobulin monotype on immunohistology, which readily leads to diagnosis, but many samples do not clearly show light-chain restriction. The aim of the present study was therefore to examine CD79a expression because some samples had reduced expression or none at all. The immunoreactivity of CD79a was categorized into three groups: positive, weakly positive and negative, compared with scattering non-neoplastic plasma cells in the same specimen. Out of 100 specimens of plasma cell myeloma, 48% were positive for CD79a, 15% were weakly positive, and 37% were negative. In contrast, overexpression of cyclinD1 was detected in 26% of examined samples. CD79a-negative cases had a significantly lower percentage of positive staining for cyclinD1 than CD79a-positive or weakly positive cases. Clinicopathological data showed that CD79a-negative expression was associated with decreased platelet numbers in patients. The present study indicates that downregulation or loss of CD79a and/or overexpression of cyclin D1, observed in 59% of neoplastic plasma cell samples, could provide a strong diagnostic clue without regard to the results of immunoglobulin light-chain restriction.

    DOI: 10.1111/j.1440-1827.2009.02448.x

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  • A case of immunotactoid glomerulopathy exhibiting nephrotic syndrome successfully treated with corticosteroids and antihypertensive therapy.(共著) 査読

    Kinomura M, Maeshima Y, Kodera R, Morinaga H, Saito D, Nakao K, Yanai H, Sada K, Sugiyama H, Makino H

    Clin Exp Nephrol13 ( 4 ) 378 - 384   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-009-0166-6

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  • Immunohistochemical staining of liver grafts with a monoclonal antibody against HCV-Envelope 2 for recurrent hepatitis C after living donor liver transplantation.(共著)

    Sadamori H, Yagi T, Iwagaki H, Matsuda H, Shinoura S, Umeda Y, Ohara N, Yanai H, Ogino T, Tanaka N

    J Gastroenterol Hepatol.22   331 - 331   2009年8月

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  • Infusion of Hypertonic Saline into the Lung Parenchyma during Radiofrequency Ablation of the Lungs with Multitined Expandable Electrodes: Results Using a Porcine Model 査読

    Tatsuhiko Iishi, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Taichi Kurose, Hiroyasu Fujiwara, Jun Sakurai, Hiroyuki Yanai, Tadashi Yoshino, Susumu Kanazawa

    ACTA MEDICA OKAYAMA63 ( 3 ) 137 - 144   2009年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The present study was performed to clarify the effect of hypertonic saline infusion into the lung parenchyma on radiofrequency ablation (RFA) of the lungs. A total of 20 ablation zones were created in 3 pigs. The ablation zones were divided into 3 groups. Group 1 (n = 6) consisted of ablation zones created by applying smaller radiofrequency (RF) power without saline infusion; group 2 (n = 5) zones were created by applying greater RF power without saline infusion; and group 3 (n = 9) zones were created by applying greater RF power with saline infusion. The techniques of saline infusion included administration of hypertonic saline 1 ml before RFA, followed by continuous administration at a rate of 1 ml/min during the first 2 min after the initiation of RFA. The ablation parameters and coagulation necrosis volumes were compared among the groups. Group 3 had a tendency toward smaller mean impedance than group 1 (p = 0.059) and group 2 (p = 0.053). Group 3 showed significantly longer RF application time than group 2 (p = 0.004) and significantly greater maximum RF power than group 1 (p = 0.001) and group 2 (p = 0.004). Group 3 showed significantly larger coagulation necrosis volume (mean, 1,421 mm(3)) than group 2 (mean, 858 mm(3), p = 0.039) and had a tendency toward larger necrosis volume than group 1 (mean, 878 mm(3), p = 0.077). Although this small study had limited statistical power, hypertonic saline infusion during RFA appeared to enlarge coagulation necrosis of the lung parenchyma.

    DOI: 10.18926/AMO/31848

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  • Immunohistochemical staining of liver grafts with a monoclonal antibody against HCV-Envelope 2 for recurrent hepatitis C after living donor liver transplantation 査読

    Hiroshi Sadamori, Takahito Yagi, Hiromi Iwagaki, Hiroaki Matsuda, Susumu Shinoura, Yuzo Umeda, Nobuya Ohara, Hiroyuki Yanai, Tetsuya Ogino, Noriaki Tanaka

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY24 ( 4 ) 574 - 580   2009年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

    We evaluated the expression of hepatitis C virus (HCV) antigen on liver grafts by immunohistochemical staining (IHS) using IG222 monoclonal antibody (mAb) against HCV-envelope 2 (E2).
    The study material was 84 liver biopsy specimens obtained from 28 patients who underwent living donor liver transplantation (LDLT) for HCV infection. The biopsy samples were examined histopathologically, and by IHS using IG222 mAb against HCV-E2. Serum HCV-RNA level was measured in all patients. The IHS grades were compared among the three groups classified according to the time elapsed from LDLT (at 1-30, 31-179 and >= 180 days post-LDLT) and among four post-transplant conditions, including acute cellular rejection (ACR).
    Immunoreactivity to IG222 was detected in 78.6% of the specimens obtained during the first month after LDLT, and there were no significant differences on the IHS grades between the three groups classified according to the time elapsed from LDLT. The IHS grades were significantly stronger in definite recurrent HCV (n = 12) and probable recurrent HCV (n = 7) than in definite ACR (n = 7) and other complications (n = 8). There were no significant differences in serum HCV-RNA levels among the four post-transplant conditions. There was no significant correlation between the IHS grades using IG222 mAb and serum HCV-RNA levels when data of 84 liver biopsy specimens were analyzed.
    Constant HCV-E2 expression was observed in liver biopsy specimens obtained 1 month or longer. The strong HCV-E2 expression on liver grafts were associated with recurrent hepatitis C after LDLT, but the serum HCV-RNA levels were not.

    DOI: 10.1111/j.1440-1746.2008.05638.x

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  • A case of small early cancer of sigmoid colon, which recurred with liver metastasis 18 months after surgical resection 査読

    Keita Harada, Jun Kato, Koji Takemoto, Toshio Uraoka, Sakiko Hiraoka, Hiroyuki Yanai, Kazuhide Yamamoto

    Journal of Japanese Society of Gastroenterology106 ( 5 ) 660 - 667   2009年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    A 74-year-old man was referred to our hospital with positive fecal occult blood test. Colonoscopic examination revealed a 7-mm 0-Is type polyp in the sigmoid colon. Endoscopic mucosal resection for this lesion completely removed the lesion and the histologic diagnosis was well differentiated adenocarcinoma. Cancer cells invaded the submucosa to a depth of 900μm, and vascular invasion was found. Therefore, the patient underwent additional surgical resection with lymph node dissection. During follow-up, however, serum CEA increased beyond the normal limit 18 months after surgical operation, and a 15-mm single liver metastasis was found through enhanced CT scan abdominal imaging, the FDG-PET scan, and ultrasonography. We have to pay attention to metachronous liver metastasis especially when the vascular invasion is suspected in the resected sample, even if the lesion is completely removed.

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  • Frequent p16 inactivation by homozygous deletion or methylation is associated with a poor prognosis in Japanese patients with pleural mesothelioma 査読

    Naruyuki Kobayashi, Shinichi Toyooka, Hiroyuki Yanai, Junichi Soh, Nobukazu Fujimoto, Hiromasa Yamamoto, Shuji Ichihara, Kentaro Kimura, Kouichi Ichimura, Yoshifumi Sano, Takumi Kishimoto, Hiroshi Date

    LUNG CANCER62 ( 1 ) 120 - 125   2008年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    This study examined the p16 expression status and the P16 gene deletion and methylation status in specimens from Japanese patients with malignant pleural mesothelioma (MPM). lmmunohistochemical staining for p16 protein and fluorescence in situ hybridization for the P16 gene were performed using specimens from 30 Japanese patients with primary MPM. The methylation status of the P16 gene was examined in 13 patients whose frozen tumor specimens were available using a methylation-specific PCR assay. Among the 30 patients, the toss of p16 protein expression was observed in 24 patients (80.0%). Twenty-one patients had homozygous deletions, and 9 patients retained the P16 gene. None of the patients with P16 homozygous deletions exhibited p16-positive expression, and 3 patients who retained the P16 gene did not exhibit p16-positive expression. Aberrant P16 methylation was present in two patients with an intact P16 gene but without p16 expression. These results suggest that either a homozygous deletion or methylation is responsible for P16 inactivation. Regarding the prognosis, patients with p16-negative expression had a significantly shorter survival. time than those with p16-positive expression (P=0.040). Our study showed that P16 inactivation by homozygous deletions or methylation is a frequent event in Japanese patients with MPMs, relating to poor prognosis. Homozygous deletion is the major cause of P16 inactivation, but methylation also lead to the inactivation of P16 when the P16 alleles are retained. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.lungcan.2008.02.013

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  • Immunohistochemistry of p63 in primary and secondary vulvar Paget's disease 査読

    Hiroyuki Yanai, Narihisa Takahashi, Masako Omori, Wakako Oda, Ichiro Yamadori, Shin-ichi Takada, Hiroo Matsuura, Tadashi Yoshino

    PATHOLOGY INTERNATIONAL58 ( 10 ) 648 - 651   2008年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Vulvar Paget's disease (VPD) is classified into primary and secondary types. Differentiation of these subsets in biopsy specimen is important for appropriate therapy. Expression profile of cytokeratin (CK) 7 and CK20, gross cystic disease fluid protein-15 and uroplakin III has been reported as a differentiation marker of primary and secondary VPD. To examine the role of p63 immunostaining in differential diagnosis between primary VPD and VPD secondary to urothelial carcinoma (VPD-UC), expression of p63 was examined in nine cases of VPD. Paget cells in seven cases of VPD without UC did not express p63. In two cases of VPD associated with UC, Paget cells and UC cells had identical CK expression profile. UC cells were positive for p63 in both cases. In one case, Paget cells were positive for p63 and examination of the resected specimen showed that VPD was secondary to UC. In another case, Paget cells were negative for p63 and this was diagnosed as primary VPD independent of UC. This indicates that p63 is absent in Paget cells in primary VPD and is therefore useful in differentiating primary VPD from VPD-UC.

    DOI: 10.1111/j.1440-1827.2008.02284.x

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  • Orbital exenteration after transarterial embolization in a patient with Wyburn-Mason syndrome: Pathological findings 査読

    Toshihiko Matsuo, Hiroyuki Yanai, Kenji Sugiu, Susumu Tominaga, Yoshihiro Kimata

    JAPANESE JOURNAL OF OPHTHALMOLOGY52 ( 4 ) 308 - 313   2008年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER TOKYO  

    Background: We present the pathological findings at orbital exenteration in a patient with Wyburn-Mason syndrome who underwent transarterial embolization.
    Case: A 31-year-old man with a 10-year history of gradual exacerbation of left exophthalmos and left cheek swelling was found to have facial and orbital arteriovenous malformations on the left side. There was no vascular malformation in the brain. The feeding arteries derived from the left internal maxillary artery, facial artery, and ophthalmic artery. He underwent several courses of transarterial embolization of the feeding arteries from the left internal maxillary artery and then from the facial artery, resulting in no reduction of the arteriovenous malformation. He finally elected to undergo ophthalmic artery embolization in the expectation of a reduction and with the understanding that he would lose sight in his left eye. Two years later, he requested lid-sparing orbital exenteration and reconstruction with cutaneous flap transfer and prosthesis for cosmetic reasons.
    Observations: Pathologically, orbital vascular channels of varying sizes were filled with embolizing glue and had degenerating vascular wall cells surrounded by inflammatory cell infiltration. The central retinal artery in the optic nerve was also filled with the embolizing glue, and the retina lost the ganglion cell layer and inner nuclear layer but maintained the outer nuclear layer and outer segments.
    Conclusions: Marked anastomoses and hence incomplete embolization among the feeding arteries of facial and orbital vascular malformations in Wyburn-Mason syndrome do not respond well to attempts at feeding vessel embolization, which result in unsuccessful closure of the malformation.

    DOI: 10.1007/s10384-008-0563-5

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  • Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas 査読

    Y. Sato, K. Ichimura, T. Tanaka, K. Takata, T. Morito, H. Sato, Y. Sato, E. Kondo, H. Yanai, N. Ohara, T. Oka, T. Yoshino

    JOURNAL OF CLINICAL PATHOLOGY61 ( 3 ) 377 - 381   2008年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:B M J PUBLISHING GROUP  

    Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found in the duodenum. They are often localised tumours with multiple polyps around the ampulla of Vater.
    Aims: To examine a IgH/bcl-2 hybrid gene and VH gene to investigate the nature of the lymphoma cells and how they differ from nodal follicular lymphomas and MALT lymphomas.
    Methods: Of 40 patients reported previously, 35 with duodenal follicular lymphoma were studied in detail with respect to clinicopathological characteristics.
    Results: 37/40 patients were in clinical stage I (n= 30) or stage II (n= 7). Clonal immunoglobulin gene rearrangement was detected in 53.3% of examined cases, and rearrangement of IgH/bcl-2 gene at the major break point was detected in 27% of cases. Three of 8 examined cases were VH4 (38%); 2 out of them were VH4-34. As VH4 deviation is one of the common characteristics of MALT lymphomas and 2/3 were identical, duodenal follicular lymphomas have a similar aetiology to MALT lymphomas. Clinical course was also similar to that of MALT lymphomas.
    Conclusions: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.

    DOI: 10.1136/jcp.2007.049825

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  • A rare tumor in the adrenal region: Neuron-specific enolase (NSE)-producing leiomyosarcoma in an elderly hypertensive patient 査読

    Junko Goto, Fumio Otsuka, Ryo Kodera, Tomoko Miyoshi, Masaru Kinomura, Hiroyuki Otani, Yukari Mimura, Toshio Ogura, Hiroyuki Yanai, Yasutomo Nasu, Hirofumi Makino

    ENDOCRINE JOURNAL55 ( 1 ) 175 - 181   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN ENDOCRINE SOC  

    A 73-year-old Japanese woman was referred for examination of right flank pain and progressive hypertension. Abdominal CT incidentally detected a right adrenal mass 8 cm in size. The tumor exhibited isodensity by CT and contained high-intense lesion by T2-weighted MRI. Scintigraphy with I-131-metaiodobenzylguanidine and I-131-adosterol showed no abnormal uptake by whole body scan. Positron emission tomography scan with F-18-2-fluoro-D-deoxyglucose demonstrated an exclusive uptake in the right adrenal mass. Adrenocortical hormone levels and catecholamine secretion were within normal range; however, the level of serum neuron-specific enolase (NSE) was found to be markedly high. After controlling systemic blood pressure with an alpha 1-blocker, the right adrenal tumor was surgically removed, along with the right kidney and inferior vena cava which adhered to it. The tumor was pathologically proven to be leiomyosarcoma, which was immunohistochemically positive with a-smooth muscle actin and negative with CD57, S-100 and c-kit proteins. Notably, NSE protein was massively expressed in the resected tumor. After surgery blood pressure was controlled with regular medication and serum NSE levels have since normalized. The possibility of leiomyosarcoma should be kept in mind in adrenal incidentalomas with rapid growth and atypical radiological images. Our findings suggest that circulating NSE levels may be clinically useful for early detection of recurrence.

    DOI: 10.1507/endocrj.K07E-020

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  • A novel variant apolipoprotein E Okayama in a patient with lipoprotein glomerulopathy 査読

    Masaru Kinomura, Hitoshi Sugiyama, Takao Saito, Akira Matsunaga, Ken-ei Sada, Motoko Kanzaki, Yuki Takazawa, Yohei Maeshima, Hiroyuki Yanai, Hirofumi Makino

    NEPHROLOGY DIALYSIS TRANSPLANTATION23 ( 2 ) 751 - 756   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    DOI: 10.1093/ndt/gfm675

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  • 悪性転化を示したnuclear palisadingを伴う隆起性皮膚線維肉腫の1例 査読

    大森昌子, 柳井広之, 荻野哲也, 松川昭博, 吉野正

    診断病理25   72 - 76   2008年

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  • Risk factors for recurrence and unfavorable prognosis in patients with stage I non-small cell lung cancer and a tumor diameter of 20 mm or less 査読

    Naruyuki Kobayashi, Shinichi Toyooka, Junichi Soh, Kouichi Ichimura, Hiroyuki Yanai, Hiroshi Suehisa, Shuji Ichihara, Masaomi Yamane, Motoi Aoe, Yoshifumi Sano, Hiroshi Date

    JOURNAL OF THORACIC ONCOLOGY2 ( 9 ) 808 - 812   2007年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background: The purpose of this study was to identify risk factors for disease recurrence and unfavorable prognosis after surgical resection for stage I non-small cell lung cancer in patients with tumor diameters of <= 20 mm.
    Methods: One hundred sixty-three patients who had pathologic stage I non-small cell lung cancer with tumor diameters <= 20 mm and who had undergone a lobectomy with mediastinal lymph node dissection were retrospectively reviewed. The relationships between clinicopathologic factors and clinical outcomes, including recurrence and survival, were then examined. The clinicopathologic factors examined in this study were age, sex, smoking status, preoperative serum carcinoembryonic antigen level, pathologic tumor size, histologic subtype, histologic grade, and visceral pleural invasion.
    Results: Among the clinicopathologic factors that were examined, the histologic grade of the carcinoma status was significantly related to a high risk of recurrence when analyzed using univariate (p = 0.01) and multivariate analyses (p = 0.049). Regarding survival, patients with poorly differentiated carcinomas showed a significantly unfavorable overall survival (p < 0.001), disease-specific survival (p = 0.003), and disease-free survival (p = 0.002) compared with patients with well-/moderately differentiated carcinomas according to univariate analyses. A Cox proportional hazards model indicated that a poorly differentiated carcinoma status was the only independent factor for an unfavorable overall survival (p = 0.02), disease-specific survival (p = 0.046), and disease-free survival (P = 0.04).
    Conclusions: Poor differentiation of tumor was the only risk factor for recurrence and an unfavorable prognosis for stage I non-small cell lung cancer patients with tumor diameters of <= 20 mm.

    DOI: 10.1097/JTO.0b013e31814617c7

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  • Intraductal tubular adenoma, pyloric gland-type, of the pancreas 査読

    H. Fukatsu, H. Kawamoto, K. Tsutsumi, H. Kato, K. Hirao, N. Kurihara, T. Ogawa, E. Ishida, Y. Okamoto, H. Okada, K. Sakaguchi, H. Yanai

    ENDOSCOPY39 ( Suppl 1 ) E88 - E89   2007年2月

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    記述言語:英語   出版者・発行元:GEORG THIEME VERLAG KG  

    DOI: 10.1055/s-2006-945159

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  • 小児のトルコ鞍部に発生した肉芽腫性病変の一例.

    神原啓和, 市川智継, 茶山公祐, 宮村能子, 大森昌子, 柳井広之, 伊達 勲

    瀬戸内脳神経外科懇話会会誌15   20 - 24   2007年

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  • 非定型奇形腫様/ラブドイド腫瘍 atypical teratoid/rhabdoid tumor (AT/RT)の1例.

    大森昌子, 柳井広之, 荻野哲也, 井上 智, 市川智継, 松川昭博, 吉野 正

    診断病理24 ( 1 ) 115 - 120   2007年

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  • 救命しえた劇症型好酸球性心筋炎の1例.

    大郷恵子, 圓光賢希, 草野研吾, 桜木 悟, 永瀬 聡, 中村一文, 柳井広之, 大森昌子, 大家政志, 難波靖治, 津田佳穂, 大江 透

    心臓39   112 - 117   2007年

  • TUR-BT前後におけるFollow up尿細胞診の意義について.

    佐藤正和, 平本直美, 有安早苗, 山鳥一郎, 柳井広之, 吉野 正

    日本臨床細胞学会岡山支部会誌26   29 - 31   2007年

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  • 当院におけるテレパソロジーの現状.

    森谷恭子, 藤村紀行, 羽原利幸, 櫛田あけみ, 園部宏, 柳井広之, 大森昌子

    広島県臨床検査技師会誌100   31 - 33   2007年

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  • 高血圧の精査にて発見されたNSE産生性副腎平滑筋肉腫の一例.

    後藤順子, 大塚文男, 小寺亮, 稲垣兼一, 三好智子, 大谷寛之, 鈴木二郎, 三村由香里, 小倉俊郎, 那須保友, 柳井広之, 槇野博史

    日本内分泌学会雑誌83   242 - 245   2007年

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  • 化学療法が無効であったが、MPA療法が有効であった子宮体癌IVb期の一例.

    清水美幸, 関 典子, 児玉順一, 舛本明生, 松尾 環, 中村圭一郎, 本郷淳司, 平松祐司, 柳井広之

    日本産科婦人科学会中国四国合同地方部会雑誌55 ( 3 ) 99 - 103   2007年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Radiofrequency ablation of normal lungs after pulmonary artery embolization with use of degradable starch microspheres: Results in a porcine model 査読

    Takao Hiraki, Hideo Gobara, Jun Sakurai, Hidefumi Mimura, Takashi Mukai, Soichiro Hase, Toshihiro Iguchi, Hiroyasu Fujiwara, Nobuhisa Tajiri, Hiroyuki Yanai, Tadashi Yoshino, Susumu Kanazawa

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY17 ( 12 ) 1991 - 1998   2006年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    PURPOSE: The present study was performed to evaluate the effect of pulmonary artery embolization on radiofrequency (RF) ablation of normal porcine lungs.
    MATERIALS AND METHODS: RF ablation zones (n = 34) were created in the normal lungs of five domestic pigs (five zones in each of the first two pigs and eight zones in each of the remaining three pigs) with an expandable multitined electrode with use of bilateral thoracotomy. RF ablation was performed without pulmonary artery embolization (group 1, n = 8), immediately after embolization (group 2, n = 11),15 minutes after embolization (group 3, n = 7), and 30 minutes after embolization (group 4, n = 8) with degradable starch microspheres. Among them, 12 ablation zones were excluded from this study because they were considerably limited by the presence of the pleura or large bronchi. The remaining 22 zones were included (n = 7, n = 5, n = 4, and n = 6 in groups 1, 2, 3, and 4, respectively). Coagulation necrosis volumes in the ablation zones were measured and compared among the groups.
    RESULTS: Coagulation necrosis volumes were 0.9 +/- 0.5 cm(3), 2.1 +/- 0.4 cm(3), 2.1 +/- 1.0 cm(3), and 1.9 +/- 0.6 cm(3) in groups 1, 2, 3, and 4, respectively. Groups 2-4 showed significantly larger coagulation volumes than group 1 (P = .012, P = .023, and P = .010 in groups 2, 3, and 4, respectively).
    CONCLUSION: Pulmonary artery embolization contributed to larger volumes of coagulation necrosis after RF ablation of normal lungs.

    DOI: 10.1097/01.RVI.0000251152.12254.AC

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  • Follicular lymphoma frequently originates in the salivary gland. 査読 国際誌

    Satoko Nakamura, Koichi Ichimura, Yumiko Sato, Shigeo Nakamura, Hirokazu Nakamine, Hiroshi Inagaki, Yoshito Sadahira, Koichi Ohshima, Sumie Sakugawa, Eisaku Kondo, Hiroyuki Yanai, Nobuya Ohara, Tadashi Yoshino

    Pathology international56 ( 10 ) 576 - 83   2006年10月

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    記述言語:英語  

    The aim of the present study was to examine the clinicopathological presentations of follicular lymphomas (FL) of the salivary glands, as compared to mucosa-associated lymphoid tissue (MALT) lymphomas. A total of 27 primary salivary gland lymphomas were examined: 6 FL (five, grade 1; one, grade 2); 19 MALT lymphomas; and two diffuse large B-cell lymphomas. The FL patients ranged in age from 24 to 73 years, with a mean of 49 years, which was younger than that of MALT patients (mean: 64 years; P < 0.05). Four of the six FL arose from the submandibular gland, which was the origin of only five out of a total of 19 MALT lymphomas. One FL patient was in clinical stage (CS) IE, two in CS IIE, and two in CS III and IV. As regards the MALT lymphoma patients, 13 (68%) were in CS IE and five (26%) in CS IIE. None of the FL patients had clinical diagnosis of autoimmune disease but eight MALT lymphoma patients had autoimmune disease. The present study found a relatively high incidence of FL in the salivary glands. The observed differences in age of onset, background of autoimmune disease, and lesion site suggests that the pathogenesis of FL may differ from that of MALT lymphoma.

    DOI: 10.1111/j.1440-1827.2006.02011.x

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  • Calcifying fibrous tumor arising from the heart 査読

    Hisayuki Shigematsu, Yoshifumi Sano, Shingo Kasahara, Hiroyuki Yanai, Hiroshi Date

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY132 ( 3 )   2006年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MOSBY, INC  

    DOI: 10.1016/j.jtevs.2006.04.042

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  • Accurate diagnosis of musculoskeletal lesions by core needle biopsy 査読

    G Mitsuyoshi, N Naito, A Kawai, T Kunisada, A Yoshida, H Yanai, S Dendo, T Yoshino, S Kanazawa, T Ozaki

    JOURNAL OF SURGICAL ONCOLOGY94 ( 1 ) 21 - 27   2006年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-LISS  

    Background: Percutaneous needle biopsy has many advantages over open biopsy in the treatment of neoplasms. However, the accuracy of needle biopsy in the diagnosis of musculoskeletal lesions has not yet been established. Here, we evaluate the accuracy and limitations of the procedure for musculloskeletal lesions.
    Methods: The diagnoses of 163 needle biopsies (bone, 91; soft tissue, 72) performed on 157 consecutive patients using a Jamshidi needle or an Ostycut needle for bone lesions, or a Tru-cut needle for soft tissue lesions were compared with the final diagnoses made by open biopsy and/or a definitive operation.
    Results: One hundred forty-three specimens (88%) were determined to be adequate for histological examination. Obtaining undamaged cores from very hard bony lesions or sclerotic cyst walls proved difficult. A pathologist with experience in musculoskeletal lesions was able to differentiate malignant tumors from benign lesions in 97% of the cases (bone, 100%; soft tissue, 94%) and arrive at a specific diagnosis in 88% (bone, 96%; soft tissue, 78%) when adequate cores were obtained. Differentiating a well-differentiated liposarcoma from a benign lipoma and inflammatory lesions from benign tumorous conditions, was difficult. The overall accuracy was 77% (bone, 85%; soft tissue, 68%). There was no morbidity related to the procedure.
    Conclusion: The results indicate that needle biopsy is safe and accurate for diagnosing musculoskeletal lesions.

    DOI: 10.1002/jso.20504

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  • Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung 査読

    S Toyooka, Y Yatabe, M Tokumol, K Ichimura, H Asano, K Tomii, H Yanai, H Date, T Mitsudomi, N Shimizu

    INTERNATIONAL JOURNAL OF CANCER118 ( 6 ) 1588 - 1590   2006年3月

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    記述言語:英語   出版者・発行元:WILEY-LISS  

    DOI: 10.1002/ijc.21500

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  • p53 protein transduction therapy: Successful targeting and inhibition of the growth of the bladder cancer cells 査読

    Miyabi Inoue, Kazuhito Tomizawa, Masayuki Matsushita, Yun-Fei Lu, Teruhiko Yokoyama, Hiroyuki Yanai, Atsushi Takashima, Hiromi Kumon, Hideki Matsui

    European Urology49 ( 1 ) 161 - 168   2006年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Introduction: Virus-mediated gene therapy for bladder cancer has some problems, such as efficiency of gene delivery and safety issues. We have reported that poly-arginine peptide (11R) has the ability to increase protein transduction in cells. Here, we show that p53 protein transduction using 11R is useful for targeting to bladder tumors and suppressing the growth of bladder cancer cells. Materials and methods: An 11R-fused p53 protein (11R-p53) was transduced in bladder cancer cell lines (J82 and T24) to evaluate the anti-tumor effect. Cell viability was assessed by performing the 4-[3-(4-iodophenyl)-2-(4- nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST) assay. To investigate whether 11R-p53 enhanced the effect on anti-cancer drug-dependent apoptosis of bladder cancer cells, the cell lines were cotreated with 11R-p53 and cis-diaminedichloroplatinum (CDDP). Apoptotic cells were identified using Hoechst staining. To investigate the efficiency of protein transduction mediated by 11R in bladder tumors in vivo, SCID mice were transplanted with J82 cells in the bladder and 11R-GFP was transurethrally transduced into the bladder. The transduction of 11R-GFP in the tumor was examined by confocal microscopy. Results: 11R-p53 inhibited the growth of both J82 and T24 cells in a dose-dependent manner. The transduction of 11R-p53 enhanced CDDP-dependent induction of apoptosis. Transurethral application of 11R-GFP resulted in transduction of GFP in bladder tumors but not in the normal bladder epithelium or subepithelial tissues. Conclusion: The present results suggest that p53 protein transduction therapy may be a promising method for the treatment of bladder cancer. © 2005 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.eururo.2005.08.019

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  • 膀胱癌を原発とする続発性外陰Paget病の一例 ?主として術前診断にいたるまで?

    関 典子, 児玉順一, 松尾 環, 小島洋二郎, 中村圭一郎, 本郷淳司, 平松祐司, 柳井広之, 津島知靖

    日本産科婦人科学会中国四国合同地方部会雑誌   2006年

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  • 乳癌術前化学療法の効果判定における画像診断 われわれが経験した病理判定と画像診断の不一致症例について

    松岡順治, 田渕陽子, 伊藤充矢, 小野亮子, 今田孝子, 元木崇之, 松川啓義, 大森昌子, 柳井広之, 猶本良夫, 田中紀章

    岡山医学会雑誌   2006年

  • Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms. 査読 国際誌

    Eisaku Kondo, Takayoshi Miyake, Masao Shibata, Toshikazu Kimura, Hiromi Iwagaki, Shin-Ichi Nakamura, Takehiro Tanaka, Nobuya Ohara, Koichi Ichimura, Takashi Oka, Hiroyuki Yanai, Futoshi Shibasaki, Tadashi Yoshino

    Clinical cancer research : an official journal of the American Association for Cancer Research11 ( 20 ) 7255 - 63   2005年10月

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    記述言語:英語  

    PURPOSE: Bcl-2 is a model apoptosis suppressor postulated to promote tumorigenesis. Recently, it has been reported that Bcl-2 undergoes phosphoregulation of its Ser70 to substantially alter its molecular function. Previous studies further suggest that such phospho-Bcl-2 regulation may influence tumor progression in colorectal and other cancers; however, phosphorylation status of the Ser70 of Bcl-2 (pSer70) in vivo in tumors remains obscure. To elucidate this question that may suggest the biological role, we molecularly screened a panel of human colorectal adenomas and adenocarcinomas for endogenous expression of pSer70 Bcl-2. EXPERIMENTAL DESIGN: An antibody specific against pSer70 Bcl-2 was generated for thorough immunohistochemical examination of paraffin-embedded tumor specimens, allowing detection of the endogenously expressed antigen among a range of Bcl-2-positive colorectal neoplasms, including 75 tubular adenomas, 114 adenocarcinomas, and 15 cases of cancer in adenomas. RESULTS: Loss of pSer70 Bcl-2 expression was observed in adenocarcinomas in a differentiation-dependent manner (positivities: well differentiated 63%, moderately differentiated 52%, and poorly differentiated 12%), whereas tubular adenomas maintained their expression (positivity 88%). Interestingly, an inverse correlation was found between expression of pSer70 Bcl-2 and Ki-67 antigen in those cases of cancer in adenoma (P < 0.01). It was further observed that loss of pSer70 Bcl-2 expression was associated with significantly shorter survival (P < 0.05) and correlated with clinical stages and lymph node metastasis (P < 0.05 and P < 0.05, respectively). CONCLUSIONS: Loss of pSer70 Bcl-2 expression is closely linked to biological aggressiveness in colorectal tumors and represents a statistically significant molecular index for prognosis of patients with these tumors.

    DOI: 10.1158/1078-0432.CCR-05-0274

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  • A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy 査読

    A Nakatsuka, Y Maeshima, A Sarai, H Yanai, H Sugiyama, Y Yamasaki, H Makino

    CLINICAL NEPHROLOGY64 ( 3 ) 221 - 227   2005年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:DUSTRI-VERLAG DR KARL FEISTLE  

    We report a case of light and heavy chain deposition disease (LHCDD), a rather rare monoclonal immunoglobulin deposition disease (MIDD) with successful therapeutic effect. A 58-year-old woman suffered from proteinuria and renal insufficiency (serum creatinine 1.0 mg/dl, creatinine clearance 49.2 ml/min) in February 2003. In serum and urine samples, monoclonal IgG-kappa was detected. A bone marrow aspiration showed a slightly hypocellular marrow and plasma cell population was increased to 7.0%. Renal histological findings revealed lobulated glomeruli with nodular lesions on light microscopy, characteristic findings of MIDD. Intense deposition of IgG heavy chains in the linear pattern in the glomerular and tubular basement membranes was observed. Immunohistochemistry revealed both kappa and lambda light chain depositions in glomeruli. Electron-microscopic examination revealed fine granular electron-dense deposits accompanied by microfibrils. Based on these findings, this patient was diagnosed as LHCDD. She received three courses of melphalan and prednisone chemotherapy, resulting in disappearance of proteinuria, prevention of renal functional deterioration and the decrease of monoclonal immunoglobulin. This case clearly demonstrates that the earlier and accurate diagnosis and initiation of chemotherapy at the early stage with serum creatinine level below 4.0 mg/dl are necessary to improve renal and patient outcome.

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  • P53 protein transduction therapy: Successful inhibition of the growth and targeting to the bladder cancer cells 査読

    M Inoue, T Yokoyama, K Tomizawa, H Matsui, H Kumon

    JOURNAL OF UROLOGY173 ( 4 ) 160 - 160   2005年4月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1016/j.eururo.2005.08.019

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  • 炎症性筋線維芽細胞性腫瘍の一例.

    井上博文, 藤田 勝, 松岡博美, 今井みどり, 森下由美子, 中村聡子, 市村浩一, 大森昌子, 柳井広之, 吉野 正

    日本臨床細胞学会岡山支部会誌   2005年

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  • 充実部分を伴う子宮広間膜腫瘍(いわゆる傍卵巣腫瘍)の二例.

    関 典子, 児玉順一, 中村洋二郎, 中村圭一郎, 本郷淳司, 水谷靖司, 平松祐司, 柳井広之

    日本産科婦人科学会中国四国合同地方部会雑誌   2005年

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  • 多発性の後腹膜神経節細胞腫(ganglioneuroma)の1例.

    平木隆夫, 三村秀文, 柳井広之, 郷原英夫, 向井 敬, 長谷聡一郎, 藤原寛康, 金澤 右

    臨床放射線   2005年

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  • Chordoid meningiomaの1例. 国際誌

    橋本吉規, 柳井広之, 大森昌子, 田口孝爾, 松井利浩, 吉野 正

    岡山外科病理雑誌36 ( 2 ) 198 - 201   2004年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 膵管内発育を示した悪性膵内分泌腫瘍の1例.

    岡村督子, 浦島正喜, 石川雅基, 古本大典, 松浦明子, 大田 辰, 樫本和樹, 影本正之, 中川昌浩, 青木秀樹, 高倉範尚, 柳井広之, 松浦博夫

    腹部画像診断アトラス   2004年

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  • 大腸癌1,026例の臨床病理学的検討

    小野田 正, 小林直広, 大野 聡, 元木崇之, 原野雅生, 佐々木, 寛, 青木秀樹, 塩崎滋弘, 桧垣健二, 池田俊行, 二宮基樹, 高倉範尚, 柳井広之, 松浦博夫

    広島医学   2003年

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  • Sentinel Node Biopsy(SNB)に基づいた腋窩非郭清手術の現状と問題点

    桧垣 健二, 黒田, 新士, 窪田, 康浩, 原野, 雅生, 佐々木, 寛, 二宮, 基樹, 高倉, 範尚, 影本 正之, 柳井, 広之, 松浦, 博夫

    乳癌の臨床   2003年

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  • Perivascular epithelioid cell tumor of the jejunum 査読

    H Yanai, H Matsuura, H Sonobe, S Shiozaki, K Kawabata

    PATHOLOGY RESEARCH AND PRACTICE199 ( 1 ) 47 - 50   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:URBAN & FISCHER VERLAG  

    Certain HMB-45-positive epithelioid cell tumors have recently been categorized under a unified concept: perivascular epithelioid cell tumor (PEComa). In this report, we describe a jejunal PEComa arising in a 32-year-old woman without other tumors or stigmata of tuberous sclerosis. The tumor consisted of nests of epithelioid cells with clear to granular eosinophilic cytoplasm. The nests were separated by thin fibrovascular septa. The tumor cells were positive for HMB-45 and progesterone receptor, and negative for cytokeratin, epithelial membrane antigen, vimentin, desmin, a-smooth muscle actin and CD34. RT-PCR analysis failed to reveal fusion transcript ETW/ATF1, which is characteristic of clear cell sarcoma of the soft parts. She developed a recurrent tumor at the pelvic wall and the left ovary at 13 and 25 months after the first operation, respectively. Each tumor was resected surgically, and no additional therapy was performed. We think the tumor of this case is a malignant form of PEComa because of the clinical history of multiple recurrences and the size of the primary tumor. Our case underscores that to make a correct diagnosis, clinical information and immunohistochemical examination are essential.

    DOI: 10.1078/0344-0338-00353

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  • タモキシフェン投与中の女性に生じた子宮内膜ポリープ内carcinosarcoma.

    柳井, 広之, 松浦, 博夫

    岡山外科病理雑誌   2003年

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  • Immature teratoma of the ovary with a minor rhabdomyosarcomatous component and fatal rhabdomyosarcomatous metastases: The first case in a child 査読

    H Yanai, H Matsuura, M Kawasaki, Y Takada, Y Tabuchi, T Yoshino

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY21 ( 1 ) 82 - 85   2002年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    A case of ovarian immature teratoma with rhabdoniyosarcomatous recurrence in a 6-year-old girt is described. The primary tumor consisted of a dermoid cyst and a solid nodule composed of mature and immature mesenchymal tissue. The most immature mesenchymal cells showed no distinctive differentiation except for focal rhabdomyoblastic differentiation . The primary tumor was diagnosed as immature teratoma. grade 2, stage IIa. Despite left oophorectomy and excision of uterine serosal implants, chemotherapy. and radiation, four intrapelvic recurrences developed within 3 years. Although the primary tumor contained only a few, rhabdomyoblasts, the recur-rent rumors became increasingly rhabdomyosarcomatous. The patient died of systemic disease 3 years after presentation. This case and previous reports indicate that the prognosis of patients with ovarian immature teratoma with rhabdoniyosarcomatous recurrence is poor and similar to that of primary ovarian rhabdomyosarcoma.

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  • 急性壊死性好酸球性心筋炎の一剖検例

    柳井広之, 松浦博夫, 白神邦浩

    病理と臨床   2002年

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  • Ovarian stromal tumor with minor sex cord elementsの1例

    柳井広之, 松浦博夫

    岡山外科病理雑誌   2002年

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  • 卵巣外発生と考えられた莢膜細胞腫の1例

    柳井広之

    日本婦人科腫瘍学会雑誌   2002年

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  • 根治性、機能性、整容性を兼ね備えた乳房温存術式

    桧垣健二, 鵜垣伸也, 小野田 正, 高倉範尚, 樋口富美, 影本正之, 柳井広之, 松浦博夫

    乳癌の臨床   2002年

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  • 進行・再発乳癌に対するHerceptinの使用経験

    桧垣健二, 畝 大, 藤原康弘, 鵜垣伸也, 原野雅生, 佐々木 寛, 小野田 正, 塩崎滋弘, 高倉範尚, 柳井広之, 松浦博夫

    広島医学   2002年

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  • 内視鏡的切除後に外科的追加切除を施行した早期大腸癌症例の検討

    中川昌浩, 横田恭子, 岡本賢三, 仁科慎一, 久松倫子, 岡本裕子, 石井泰史, 有吉正憲, 河本博文, 長島不二夫, 杉原徹, 井上純一, 柴田醇, 柳井広之, 松浦博夫

    社会保険広島市民病院医誌17 ( 1 ) 106-113   2001年3月

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  • 放射線治療が奏効し長期生存した噴門部進行胃癌の1例

    谷為乃扶子, 影本正之, 樋口富美, 本山由紀子, 松浦明子, 太田 辰, 浦島正喜, 柳井広之, 松浦博夫, 二宮基樹

    広島医学   2001年

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  • Sentinel Node Biopsyによる腋窩非郭清手術の適応拡大

    桧垣健二, 松川啓義, 今田孝子, 小野田 正, 塩崎滋弘, 高倉範尚, 樋口富美, 影本正之, 柳井広之, 松浦博夫

    乳癌の臨床   2001年

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  • MorbidityとQOLからみた乳癌に対する直視下腋窩郭清と内視鏡下腋窩郭清の比較検討

    桧垣健二, 小野田 正, 松川啓義, 徳永尚之, 清水秀二, 滝 正樹, 高倉範尚, 影本正之, 柳井広之, 松浦博夫

    乳癌の臨床   2001年

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  • 乳癌に対する乳房温存手術の適応拡大を目指して

    桧垣健二, 柳井広之, 松浦博夫

    広島医学   2001年

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  • Telangiectatic osteosarcomaの1例 国際誌

    柳井広之, 田口孝爾, 松下具敬

    岡山外科病理雑誌29 ( 10 ) 597 - 600   2000年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 腹腔内 Desmoplastic Small Round Cell Tumorの1例 査読 国際誌

    柳井広之, 松本 学, 古谷満寿美

    日本臨床細胞学会雑誌34 ( 5 ) 338 - 342   2000年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5795/jjscc.39.254

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  • S1667 小腸間膜病変(化骨性腸間膜炎)

    松浦博夫, 柳井広之, 小林直広

    病院病理   2000年

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  • 乳癌に対する腋窩非郭清手術の術後成績

    桧垣健二, 岡村進介, 森多克行, 吉鷹知也, 大崎 悟, 小野田 正, 塩崎滋弘, 影本正之, 柳井広之, 松浦博夫

    乳癌の臨床   2000年

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  • Adult mesoblastic nephroma with ciliated epithelium. A case report

    H Yanai, A Ikeda, H Kadena, M Mizutani, M Kurihara, S Matsuki

    PATHOLOGY RESEARCH AND PRACTICE196 ( 4 ) 265 - 268   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:URBAN & FISCHER VERLAG  

    A case of renal pelvic tumors occurring in a 44-year-old man is reported. There were two polypoid renal pelvic tumors which consisted of, glandular and stromal components. Some glands in the tumors had ciliated epithelium and were quite similar to the epididymal tubules. Other glands in the tumors resembled the collecting duct or the mesonephric remnant seen in female genitalia. Immunohistochemistry and electron microscopy revealed smooth muscle differentiation of the stromal cells of these tumors. Some psammoma bodies were seen in the glands of the tumors. We diagnosed these tumors as adult mesoblastic nephroma (MN). The patient has been followed up for 14 months, showing no evidence of recurrence. Differentiation of the tumors from angiomyolipoma, leiomyoma, and nephrogenic adenofibroma is discussed. Adult renal tumors that consist of epithelial and stromal components have been reported under various names. They constitute clinicopathologically different entities originating from pediatric MN. We suggest that these tumors should be termed "adult MN".

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  • 空腸原発内分泌細胞癌の1例

    竹中龍太, 友田 純, 槙殿知穂, 村上敬子, 近藤淳一, 吉岡敏文, 坂田達朗, 廣田 滋, 大川尚臣, 淵本定儀, 柳井広之

    Gastroenterol Endosc   2000年

  • 皮膚悪性黒色腫頭蓋内転移2症例

    山下史朗, 守山英二, 別宮博一, 岩戸英仁, 柳井広之

    医療   2000年

  • 劇症型G群溶連菌感染症の1例

    松浦博夫, 柳井広之, 藤井誠志

    診断病理   2000年

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  • 子宮頚部lymphoepithelioma-like carcinomaの1例 国際誌

    早瀬良二, 山本昌彦, 柳井広之

    日本婦人科腫瘍学会雑誌31 ( 4 ) 434 - 435   1999年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Cyno-EBV (EBV-related herpesvirus from cynomolgus macaques) induces rabbit malignant lymphomas and their tumor cell lines frequently show specific chromosomal abnormalities 査読

    K Hayashi, HL Chen, H Yanai, TR Koirala, N Ohara, N Teramoto, T Oka, T Yoshino, K Takahashi, K Miyamoto, K Fujimoto, Y Yoshikawa, T Akagi

    LABORATORY INVESTIGATION79 ( 7 ) 823 - 835   1999年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Malignant lymphoma (ML) induction in rabbits by Epstein-Barr virus (EBV)-related herpesvirus of cynomolgus (Cyno-EBV) is reported. Twenty-seven of 30 (90%) rabbits inoculated intravenously with Cyno-EBV-producing simian (cynomolgus) lymphocyte cell line (Ts-B6) cells developed ML between 45 and 115 days after inoculation. The peroral inoculation of Ts-B6 cells induced ML in only 2 of 10 (20%) rabbits (75 to 85 days). Five of 6 (83%) rabbits injected with cell-free pellets from Ts-B6 cultures also developed ML (27 to 122 days). Antibody response to the viral capsid antigen of EBV was also detected in sera from rabbits inoculated with Ts-B6. ML of the large cell or mixed type infiltrated diffusely in many organs, frequently involving the spleen, liver, kidneys, heart, and less frequently the lungs, lymph nodes, brain, eyes, gastrointestinal tract, thymus, and bone marrow. A chromosomal analysis of five lymphoma cell lines established from tumor-bearing rabbits revealed the rabbit karyotype. Three of these cell lines showed the chromosomal abnormalities with 12q- or t (7p+:12q-). EBV-encoded small RNA-1 and EBV-associated nuclear antigen 1 were expressed in Ts-B6 cells, the tumor tissues, and all rabbit cell lines by in situ hybridization and by immunofluorescence tests, respectively. EBV DNA was also detected in Ts-B6 cells and rabbit lymphoma cell lines by polymerase chain reaction and Southern blot analysis. The Southern blots of EBV termini revealed oligoclonal bands in the Cyno-EBV-induced rabbit lymphomas. No lymphoma was induced by the inoculation of B95-8 (EBV-producing cells) or peripheral leukocytes from normal cynomolgus (controls). These data suggest that the high rate of lymphoma induction in rabbits may be caused not by human EBV (B95-8) but by Cyno-EBV from Ts-B6 cells. A sequence analysis of the IR1 (BamHIW) region of Cyno-EBV revealed that this region is quite similar to that of herpesvirus Macaca fascicularis 1,which is a causative agent for a monkey model of AIDS-retated lymphomas. The present rabbit model of lymphoma with specific chromosomal abnormalities is very useful to clarify the role of EBV in human EBV-associated lymphoma and provides a means for studying prophylactic and therapeutic regimens.

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  • CD95 ligand is expressed in Reed-Sternberg cells of Hodgkin's disease 査読

    Sakuma, I, T Yoshino, K Omonishi, R Nishiuchi, N Teramoto, H Yanai, K Kawahara, Kubonishi, I, Y Matsuo, T Akagi

    PATHOLOGY INTERNATIONAL49 ( 2 ) 103 - 109   1999年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL SCIENCE ASIA  

    Reed-Sternberg (RS) cells and their mononuclear variants, Hodgkin's (H) cells, are considered to be the neoplastic cells of Hodgkin's disease (HD). The cellular origin of H-RS cells remains the subject of considerable controversy, although most recent papers have claimed that H-RS cells are of B cell origin, Recently, however, it has been reported that some H-RS cells express granzyme B, as observed in cytotoxic T cells and/or natural killer cells, which also express CD95 ligand (FasL/APO-1L). In the present study, the expression of CD95L and granzyme B in H-RS cells of HD was investigated, CD95L was detected in H-RS cells in five of nine HD cases (one case of lymphocyte-rich classical HD, two of these cases of nodular sclerosis type, and two of four cases of mixed cellularity type), All three examined HD cell lines expressed CD95L in the cytoplasm, although cell surface expression was seen only in L428 cells, Three HD cases expressed both CD95L and granzyme B. It was concluded that CD95L is frequently expressed in H-RS cells, which is one of their notable characteristics; albeit it seems to be irrespective of cell lineage.

    DOI: 10.1046/j.1440-1827.1999.00830.x

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  • Heterogeneity of dendritic cells in human superficial lymph node: In vitro maturation of immature dendritic cells into mature or activated interdigitating reticulum cells 査読

    Kiyoshi Takahashi, Kenji Asagoe, Jin Zaishun, Hiroyuki Yanai, Tadashi Yoshino, Kazuhiko Hayashi, Tadaatsu Akagi

    American Journal of Pathology153 ( 3 ) 745 - 755   1998年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Society for Investigative Pathology Inc.  

    A two-color immunofluorescent analysis indicated that dendritic cells (DCs) in the human axillar lymph nodes (ie, lymph nodal DCs (LnDCs)) can be classified into three subsets. The first subset consists of CD1a+/CD86(- or dim)/CD83(- or dim) nondendriform DCs found mainly in lymph sinuses, the second is of CD1a-/CD86+/CD83+ dendriform DCs scattered in normal T zones, and the third is of large CD1a(bright)/CD86+/CD83+ dendriform DCs occasionally found in hyperplastic T zones. A three-color flow cytometric analysis, immunoperoxidase staining, and electron microscopic observation indicated that the majority of LnDCs corresponded to the first subset, which showed distinctive characteristics of DCs but did not fulfill the ultrastructural criteria for interdigitating reticulum cells (IDCs) and did not contain Birbeck granules. When LnDCs were cultured for 7 days, they became large CD1a(dim)/CD86+/CD83+ dendriform cells, which formed large complexes with many T cells and exhibited distinctive ultrastructural features of interdigitating reticulum cells, LnDCs cultured in the presence of granulocyte/macrophage colony-stimulating factor became markedly larger CD1a(bright)/CD86+/CD83+ dendriform cells forming large complexes with numerous T cells. These findings suggest that cells of the first subset represent immature LnDCs just migrating from epidermis, those of the second subset represent interdigitating reticulum cells, and those of the third subset represent interdigitating reticulum cells probably stimulated with certain immunostimulatory cytokines such as granulocyte/macrophage colony- stimulating factor. It is also suggested that either the second or the third subsets of LnDCs are derived from the first subset.

    DOI: 10.1016/S0002-9440(10)65618-0

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  • Analysis of the Genome of an Epstein-Barr-Virus (EBV)-Related Herpesvirus in a Cynomolgus Monkey Cell Line (Si-IIA) 査読

    Hideo Ino, Kazuhiko Hayashi, Hiroyuki Yanai, Norihiro Teramoto, Tirtha Raj Koirala, Hong-Li Chen, Takashi Oka, Tadashi Yoshino, Kiyoshi Takahashi, Tadaatsu Akagi

    Acta Medica Okayama51 ( 4 ) 207 - 212   1997年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A simian cell line, Si-IIA, harboring Epstein-Barr-virus (EBV) -related herpesvirus (Si-IIA-EBV), produces malignant lymphoma in rabbits when administered by intravenous inoculation. In this study, we analyzed the Si-IIA-EBV genome and compared it with human EBV and herpesvirus macaca fascicularis 1 (HVMF 1 ), which is associated with B-cell lymphoma developing in SIV-infected immunosuppressed monkeys. DNA from Si-IIA-EBV was amplified by the polymerase chain reaction using three different primer pairs complementary to human EBV (B95-8) DNA
    two of the primer pairs covered part of the long internal repeat 1 region (IR 1) and the third covered part of the BRRF 1 region. Direct sequencing of the three PCR products revealed that Si-IIA-EBV DNA had about 82% nucleotide homology to the human EBV DNA in all three regions and 92.4% homology to HVMF1 in the IR1 region. The blotting pattern by Southern blot analysis was different between Si-IIA-EBV and human EBV.

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  • Malignant lymphoma induction of rabbits with oral spray of Epstein-Barr virus-related herpesvirus from Si-IIA cells (HTLV-II-transformed Cynomolgus cell line): A possible animal model for Epstein-Barr virus infection and subsequent virus-related tumors in humans 査読

    Tirtha Raj Koirala, Kazuhiko Hayashi, Hong-Li Chen, Hideo Ino, Naoyuki Kariya, Hiroyuki Yanai, Chitta Ranjan Choudhury, Tadaatsu Akagi

    Pathology International47 ( 7 ) 442 - 448   1997年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing  

    Malignant lymphoma (ML) was induced in eight of nine rabbits inoculated by oral spray of the cell-free pellets from Si-IIA culture (HTLV-II- transformed leukocyte cell line of the Cynomolgus-producing Epstein-Barr virus (EBV)-related herpesvirus) after 64-141 days. None of the rabbits inoculated with EBV from B-95-8 cells or HTLV-II from MOT cells developed ML. Malignant lymphomas were usually of diffuse, large-cell or mixed type. HTLV- II infection was excluded by the polymerase chain reaction (PCR) and the particle agglutination teat. EBV-encoded RNA-1 and EBV-related DNA were detected in the tumor tissues by in situ hybridization and PCR, respectively. Anti-viral capsid antigen of EBV antibody (anti-VCA) was observed 3 weeks after oral inoculation of Si-IIA cell-free pellets. Polymerase chain reaction revealed continuous detection of EBV-related virus DNA in the peripheral blood leukocytes from 3 days after oral inoculation. These results show that ML induced orally with Si-IIA cell-free pellets was caused by EBV-related herpesvirus harbored by Si-IIA cells. Oral spray of EBV from B-95-8 also induced EBV infection in rabbits, which was confirmed both by the presence of anti-VCA and by PCR. These oral infection and malignant lymphoma induction systems of rabbit using EBV-related virus from Si-IIA or human EBV are useful animal models for the study of EBV infection and EBV-related lymphomas in humans.

    DOI: 10.1111/j.1440-1827.1997.tb04522.x

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  • Regulation of Interleukin-2 Receptor γ Chain mRNA Expression in Human Monocytic Cell Line THP-I 査読

    Hiroyuki Yanai, Tadashi Yoshino, Kiyoshi Takahashi, Yoshifumi Ninomiya, Tadaatsu Akagi

    Acta Medica Okayama50 ( 3 ) 145 - 150   1996年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The interleukin-2 receptor (IL-2R) γ chain (γc chain) is shared by IL-4R, IL-7R, IL-9R, and IL-15R and plays an important role in regulation of the immune system. However, its regulation in monocytic cell lines has not been well clarified. We examined the expression and regulation of the IL-2Rα, IL-2Rβ, γc chain, IL-4R and IL-7R mRNA in a human monoblastic leukemia cell line, THP-1. Unstimulated THP-1 cells constitutively expressed a low level of γc chain and IL-4R mRNA, Phorbol myristate acetate (PMA) induced macrophage-like differentiation and up-regulated the γc chain mRNA expression in THP-1 cells. This effect of PMA was suppressed by the protein kinase inhibitors H-7 and staurosporine. PMA did not affect the expression of the other IL-R mRNAs examined. 1 α, 25(OH)2D3 and interferon-γ also induced differentiation of THP-1 cells, but these reagents did not affect the expression of the IL-R mRNAs in THP-1 cells. These findings suggest that the expression of the γc chain mRNA is regulated by the PMA-dependent pathway and is not associated with that of the other IL-R mRNAs.

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  • Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44 査読

    Nobuhiro Kawasaki, Yoshinobu Matsuo, Tadashi Yoshino, Hiroyuki Yanai, Takashi Oka, Norihiro Teramoto, Cao Liu, Eisaku Kondo, Jun Minowada, Tadaatsu Akagi

    Japanese Journal of Cancer Research87 ( 10 ) 1070 - 1077   1996年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Cancer Association  

    To investigate whether the lymphocyte homing receptors, adhesion molecules regulating normal lymphocyte traffic, influence the dissemination of lymphoma cells, 24 lymphoma/leukemia cell lines were inoculated into SCID mice subcutaneously, and the correlation between the expression of the adhesion molecules and the metastatic potential of the cell lines was examined. Among the six adhesion molecules examined (LFA-1, ICAM-1, CLA, VLA-4, L-selectin and CD44), L-selectin increased the incidence of lymph node metastasis, and CD44 expression was related to both lymph node and organ (hematogenous) metastasis. A monoclonal antibody to the standard form of CD44 (CD44s), Hermes-3, inhibited the local growth and remote metastasis of CD44+ cell lines. Thus, it is concluded that at least CD44s expression is important in both lymphatic and hematogenous metastasis.

    DOI: 10.1111/j.1349-7006.1996.tb03112.x

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  • Binding of human leukocytes to fibronectin is augmented by an anti-CD44 mAb (TL-1) and blocked by another anti-CD44 mAb (Hermes-3) but not by anti-VLA-4/VLA-5 mAbs 査読

    Liu Cao, Tadashi Yoshino, Nobuhiro Kawasaki, Hiroyuki Yanai, Kunimitsu Kawahara, Eisaku Kondo, Kunihiro Omonishi, Kiyoshi Takahashi, Tadaatsu Akagi

    Immunobiology196 ( 5 ) 504 - 512   1996年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier GmbH  

    Fibronectin (FN) forms meshworks in extracellular spaces, and it plays an important role in cellular trafficking. Lymphoid cells are activated by binding to FN of the VLA-4 and VLA-5 receptors. CD44 also acts as a receptor of FN, but the mechanism and physiologic regulation of their binding are poorly understood. We have developed an anti-CD44 monoclonal antibody (mAb) (TL-1) in which lymphoid cells are activated and form homotypic cell aggregation. In this study, we found that the adhesion of GEM, HSB2, and LAD lymphoid cells to FN was augmented by TL-1 treatment and was apparently blocked by another anti-CD44 mAb (Hermes-3), but TL-1 Fab' fragments treatment did not induce FN-binding. A similar phenomenon is reported in the binding of the CD44 molecule to HA. This augmentation was not inhibited by the CS1 and RGD peptides of FN or by anti-VLA-4 and -VLA-5 mAbs
    it was energy-dependent and associated with cytoplasmic actin filaments. Tl-1 treatment did not alter the cell surface expression of CD44 molecules. These findings above suggested that activated and/or altered cell surface distribution of CD44 molecules via a conformational change augmented the avidity of its binding to FN, which may be similar to lymphocyte-hyaluronate and lymphocyte-endothelial cell binding. As the Hermes-3 binding site is also involved in the interaction between lymphocytes and endothelial cells, activation of lymphocytes via CD44 molecules may facilitate the binding of lymphocytes to endothelial cells, extravasation, and migration to inflammatory sites rich in FN.

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  • Thrombotic Thrombocytopenic Purpura and Myoglobinuric Acute Renal Failure Following Radiation Therapy in a Patient with Polymyositis and Cervical Cancer 査読

    Hirofumi Makino, Yoshio Nagake, Kazuhiko Moriwaki, Shuzo Hirakawa, Zensuke Ota, Takaaki Katayama, Hiroyuki Yanai, Kiyoshi Takahashi, Tadaatsu Akagi

    Internal Medicine34 ( 1 ) 24 - 27   1995年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    73-year-old woman was admitted to receive radiation treatment for uterine cervical cancer, however a complex series of events ensued, leading to death. She developed an acute exacerbation of polymyositis complicated by thrombotic thrombocytopenic purpura, rhabdomyolysis and acute renal failure. Radiation therapy may have produced an immune disturbance leading to the acute exacerbation of polymyositis. Auto-immune-mediated endothelial damage might have triggered a series of events leading to thrombotic thrombocytopenic purpura. Rhabdomyolysis seemed to be the main cause of acute renal failure. (Internal Medicine 34: 24-27, 1995). © 1995, The Japanese Society of Internal Medicine. All rights reserved.

    DOI: 10.2169/internalmedicine.34.24

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  • 膀胱のcarcinosarcomaの一例

    柳井広之, 岡本 司, 松木 暁

    岡山外科病理雑誌32   72 - 73   1995年

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    担当区分:筆頭著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 卵巣の硬化性間質性腫瘍の1例

    柳井広之, 岡本 司, 平林光司, 早瀬良二, 赤木忠厚

    岡山外科病理雑誌31   33 - 36   1994年

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    担当区分:筆頭著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Induction of interdigitating reticulum cell-like differentiation in human monocytic leukemia cells by conditioned medium from IL-2-stimulated helper T-cells 査読

    Kiyoshi Takahashi, Katsuya Miyatani, Hiroyuki Yanai, Ho Jong Jeon, Kotaro Fujiwara, Tadashi Yoshino, Kazuhiko Hayashi, Tadaatsu Akagi, Ken Tsutsui, Koichi Mizobuchi

    Virchows Archiv B Cell Pathology Including Molecular Pathology62 ( 1 ) 105 - 113   1992年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer-Verlag  

    Monocytic leukemia (MoL) cells were obtained from the peripheral blood of a patient in whom the leukemic cells infiltrating various lymphoreticular organs exhibited features intermediate between interdigitating reticulum cells (IDC) and ordinary phagocytic macrophages, whereas the leukemic cells in the peripheral blood were essentially monocytic and lacked such features. Peripheral blood CD4+ T-cells were established as an interleukin-2-dependent T-cell line. When the MoL cells were exposed for a few days to conditioned medium from the T-cell line, they extended several dendritic cytoplasmic projections and became intensely positive for HLA-DR antigen, cytoplasmic S-100β protein, and CD1 antigen. Functionally, the conditioned medium significantly down-regulated Fc-mediated and Fc-independent phagocytic activities, and the levels of lysosomal enzymes such as lysozyme and nonspecific esterase in the MoL cells. Moreover, the conditioned medium significantly up-regulated the accessory cell function of the MoL cells as measured by the primary allogenic mixed leukocyte reaction (MLR). Furthermore, the conditioned medium significantly down-regulated the expression of CD14 antigen. Biochemical analysis indicated that the factor responsible for these changes is a protein which is distinct from known human cytokines and whose molecular weight is approximately 31 kDa. These findings suggest that IDC are closely related the monocytic lineage and that helper T-cells play an important role in constructing the microenvironment of T-lymphoid tissues which is necessary for the differentiation and maturation of IDC. © 1992 Springer-Verlag.

    DOI: 10.1007/BF02899671

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▼全件表示

書籍等出版物

  • 細胞診アトラス

    柳井広之( 担当: 共著 ,  範囲: 各論 III 婦人科 卵管・卵巣)

    文光堂  2021年4月 

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  • がんの臨床検査ハンドブック

    柳井広之( 担当: 共著 ,  範囲: 泌尿生殖器系(子宮腟細胞診,HPV含む))

    日本医事新報社  2019年1月 

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    記述言語:日本語 著書種別:学術書

  • Pathology of Female Cancers

    柳井 広之( 担当: 共著 ,  範囲: Heterogeneity of the Precursor Lesions of Endometrial Carcinoma, According to the Histologic Subtype)

    Springer  2018年9月 

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  • カラーアトラス 病理組織の見方と鑑別診断 第6版

    柳井 広之( 担当: 分担執筆 ,  範囲: 第7章生殖器 (1) 男性生殖器)

    医歯薬出版株式会社  2018年9月 

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  • 実践から学ぶ婦人科細胞診

    医療科学社  2017年 

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  • Frontiers in Ovarian Cancer Science

    Springer Singapore  2017年 

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  • 一冊でわかる婦人科腫瘍・疾患

    文光堂  2017年 

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  • 癌診療指針のための病理診断プラクティス 腎・尿路/男性生殖器腫瘍

    中山書店  2016年 

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  • 卵巣・卵管腫瘍病理アトラス (改訂・改題第2販)

    文光堂  2016年 

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  • 子宮内膜細胞診の応用

    近代出版  2015年 

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  • 癌診療指針のための病理診断プラクティス 婦人科腫瘍

    中山書店  2015年 

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  • 腫瘍病理鑑別診断アトラス 子宮体癌

    文光堂  2014年 

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  • 婦人科癌診療Q&A 一つ上を行く診療の実践

    中外医学社  2014年 

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  • 細胞診断マニュアル

    篠原出版新社  2014年 

     詳細を見る

  • 病理組織マップ&ガイド

    文光堂  2014年 

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  • 腫瘍病理鑑別診断アトラス 腎癌

    文光堂  2013年 

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  • 腫瘍病理鑑別診断アトラス 卵巣腫瘍

    柳井 広之( 担当: 共著 ,  範囲: 間質浸潤のとらえ方)

    文光堂  2012年5月 

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  • 腫瘍病理鑑別診断アトラス 腎盂・尿管・膀胱癌

    文光堂  2012年 

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  • アトラス 細胞診と病理診断

    柳井 広之, 吉野 正( 担当: 共著 ,  範囲: 子宮頸部)

    医学書院  2010年6月 

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  • カラー ダイナミック病理学

    西村書店  2010年 

     詳細を見る

  • 腫瘍病理鑑別診断アトラス 子宮頸癌

    文光堂  2009年 

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  • 腫瘍病理鑑別診断アトラス 前立腺癌

    文光堂  2009年 

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  • 子宮筋腫の臨床

    メジカルビュー,東京  2008年 

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  • 子宮腫瘍病理アトラス

    文光堂  2007年 

     詳細を見る

  • 卵巣腫瘍病理アトラス

    文光堂  2004年 

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▼全件表示

MISC

  • Fumarate hydratase(FH)欠損腎細胞癌によるリンパ節転移に対して、イピリムマブ+ニボルマブ併用療法が奏功した一例

    関戸 崇了, 高本 篤, 小林 泰之, 三井 將雄, 和田里 章吾, 窪田 理沙, 岩田 健宏, 枝村 康平, 佐古 智子, 荒木 元朗, 渡邉 豊彦, 柳井 広之, 那須 保友

    西日本泌尿器科81 ( 増刊 ) 151 - 151   2019年10月

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    記述言語:日本語   出版者・発行元:西日本泌尿器科学会  

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  • 遠隔再発・遠隔転移をきたした子宮間葉系腫瘍の臨床病理学的検討に関する小委員会報告(病理) 査読

    真田 咲子, 柳井 広之, 三上 芳喜, 大石 善丈, 牛嶋 公生, 小林 裕明, 田代 浩徳, 三上 幹男, 宮本 新吾, 片渕 秀隆

    日本婦人科腫瘍学会雑誌37 ( 3 ) 409 - 409   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 遠隔再発・遠隔転移を来した子宮間葉系腫瘍の臨床病理学的検討に関する小委員会報告(臨床) 査読

    牛嶋 公生, 三上 幹男, 田代 浩徳, 小林 裕明, 宮本 新吾, 柳井 広之, 三上 芳喜, 大石 善丈, 真田 咲子, 片渕 秀隆

    日本婦人科腫瘍学会雑誌37 ( 3 ) 408 - 408   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 中枢神経系腫瘍 RELA fusionを伴うependymosarcoma

    柳井 広之, 田中 健大, 田中 顕之, 都地 友紘

    日本小児血液・がん学会雑誌55 ( 1 ) 86 - 86   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本小児血液・がん学会  

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  • 子宮頸癌のがん医療の均てん化指標の測定に関する研究

    渡邊 ともね, 神谷 諭, 片渕 秀隆, 加藤 信吾, 金内 優典, 高橋 昌宏, 中井 英勝, 永瀬 智, 新倉 仁, 万代 昌紀, 三上 幹男, 平嶋 泰之, 柳井 広之, 山上 亘, 東 尚弘

    日本癌治療学会学術集会抄録集55回   P165 - 4   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • 【病理診断に直結した組織学】子宮体部 招待

    柳井広之

    病理と臨床35   330 - 338   2017年

     詳細を見る

    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 胆膵領域手術における病理医との連携強化の取り組み

    信岡 大輔, 八木 孝仁, 田中 顕之, 篠浦 先, 楳田 祐三, 吉田 龍一, 渡辺 信之, 杭瀬 崇, 藤 智和, 高木 弘誠, 荒木 宏之, 柳井 広之, 藤原 俊義

    日本臨床外科学会雑誌77 ( 増刊 ) 761 - 761   2016年10月

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    記述言語:日本語   出版者・発行元:日本臨床外科学会  

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  • 当院で実施しているセンチネルリンパ節生検

    加持 達弥, 梅村 啓史, 平井 陽至, 山崎 修, 岩月 啓氏, 柳井 広之

    日本皮膚科学会雑誌126 ( 11 ) 2137 - 2137   2016年10月

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    記述言語:日本語   出版者・発行元:(公社)日本皮膚科学会  

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  • 陰茎悪性黒色腫の一例

    谷本 竜太, 堀川 雄平, 西村 慎吾, 前原 貴典, 大岩 裕子, 和田 耕一郎, 小林 泰之, 荒木 元朗, 渡辺 豊彦, 山崎 修, 柳井 広之, 那須 保友

    西日本泌尿器科78 ( 増刊 ) 158 - 158   2016年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:西日本泌尿器科学会  

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  • 下顎骨内へ広範に浸潤した中咽頭腺様嚢胞癌の一例

    松崎 秀信, 河合 穂高, 野田 洋平, 松本 洋, 水川 展吉, 柳井 広之, 小野田 友男, 浅海 淳一, 木股 敬裕

    頭頸部癌42 ( 2 ) 230 - 230   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • DEB-TACE後のHCC及び正常肝実質に生じる病理学的変化に対する検討

    小牧 稔幸, 藤原 寛康, 郷原 英夫, 平木 隆夫, 生口 俊浩, 櫻井 淳, 川端 隆寛, 梶田 聡一郎, 沼 哲也, 馬越 紀行, 田中 健大, 柳井 広之, 岡田 裕之, 八木 孝仁, 金澤 右

    IVR: Interventional Radiology31 ( Suppl. ) 155 - 155   2016年4月

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    記述言語:日本語   出版者・発行元:(一社)日本インターベンショナルラジオロジー学会  

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  • 大腿に発生したintraepithelial sebaceous carcinoma

    梶田 藍, 河野 淳子, 難波 裕子, 平井 陽至, 加持 達弥, 山崎 修, 岩月 啓氏, 谷口 恒平, 柳井 広之

    日本皮膚科学会雑誌126 ( 3 ) 322 - 323   2016年3月

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    記述言語:日本語   出版者・発行元:(公社)日本皮膚科学会  

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  • 学んで活かす 病理解剖の流れと介助業務の実際 病理解剖の各工程と検査技師(介助者)の役割 臓器の摘出 Virchow法 招待

    柳井広之

    Medical Technology44 ( 5 ) 508 - 512   2016年

     詳細を見る

    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 第305回日本泌尿器科学会岡山地方会 演題抄録 転座型腎癌の3例

    井上陽介, 有吉勇一, 森 聡博, 藤尾 圭, 高本 篤, 杉本盛人, 佐々木克己, 小林泰之, 荒木元朗, 江原 伸, 渡辺豊彦, 那須保友, 柳井広之, 黒田直人

    西日本泌尿器科78 ( 5 )   2016年

     詳細を見る

  • Xp11.2転座型腎癌の3例

    井上 陽介, 高本 篤, 佐々木 克己, 森 聰博, 有吉 勇一, 小林 泰之, 荒木 元朗, 江原 伸, 渡邉 豊彦, 那須 保友, 柳井 広之, 黒田 直人

    西日本泌尿器科77 ( 増刊 ) 142 - 142   2015年10月

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    記述言語:日本語   出版者・発行元:西日本泌尿器科学会  

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  • 初回および再肝移植後に脂肪性肝炎を発症した1例

    田中 健大, 田中 顕之, 柳井 広之, 篠浦 先, 楳田 祐三, 吉田 龍一, 高木 章乃夫, 藤原 俊義, 八木 孝仁

    移植50 ( 4-5 ) 551 - 551   2015年10月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

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  • 化学療法にて組織学的CRが得られた切除不能肝内胆管原発小細胞癌の1例

    信岡 大輔, 八木 孝仁, 木村 裕司, 高木 弘誠, 須井 健太, 杭瀬 崇, 渡辺 信之, 吉田 龍一, 楳田 祐三, 篠浦 先, 堤 康一郎, 加藤 博也, 柳井 広之, 藤原 俊義

    日本臨床外科学会雑誌76 ( 増刊 ) 1117 - 1117   2015年10月

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    記述言語:日本語   出版者・発行元:日本臨床外科学会  

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  • 鼻背部動静脈瘻の1例

    土井 裕子, 山崎 修, 梅村 啓史, 岩月 啓氏, 大塚 正樹, 谷口 恒之, 柳井 広之

    日本皮膚科学会雑誌125 ( 8 ) 1606 - 1606   2015年7月

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    記述言語:日本語   出版者・発行元:(公社)日本皮膚科学会  

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  • 陰茎の結節

    山口 麻里, 大塚 正樹, 山崎 修, 市村 浩一, 柳井 広之, 岩月 啓氏

    日本皮膚病理組織学会抄録集30回   17 - 17   2014年7月

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    記述言語:日本語   出版者・発行元:日本皮膚病理組織学会  

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  • 岡山大学における前立腺癌に対するReduced Expression in Immortalized Cells遺伝子治療臨床研究 CRPC著効例の報告

    佐々木 克己, 有吉 勇一, 高本 篤, 江原 伸, 渡部 昌実, 賀来 春紀, 柳井 広之, 渡辺 豊彦, 那須 保友, 公文 裕巳

    日本泌尿器科学会総会102回   621 - 621   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本泌尿器科学会総会事務局  

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  • INVESTIGATION OF MOLECULAR HETEROGENEITY IN OVARIAN CLEAR CELL CARCINOMA IS A STEP TOWARD INDIVIDUALIZED CLINICAL THERAPY

    H. Tashiro, Y. Matsuo, H. Yanai, T. Moriya, H. Katabuchi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER23 ( 8 )   2013年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Web of Science

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  • 急速な経過をたどり死亡した腎粘液管状紡錘細胞癌の1例

    宗石 理沙, 和田 耕一郎, 田中 大介, 高村 剛輔, 倉橋 寛明, 別宮 謙介, 佐々木 克己, 荒木 元朗, 江原 伸, 渡邉 豊彦, 那須 保友, 柳井 広之, 公文 裕巳

    西日本泌尿器科75 ( 増刊 ) 137 - 137   2013年10月

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    記述言語:日本語   出版者・発行元:西日本泌尿器科学会  

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  • 卵巣漿液性境界悪性腫瘍の見方 招待

    柳井広之

    日本婦人科病理学会誌4 ( 2 ) 63 - 66   2013年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 尿路上皮癌の病理診断ー特に平坦病変についてー

    柳井広之

    岡山医学会雑誌125 ( 2 ) 113 - 117   2013年

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  • 子宮体癌の悪性度評価に関わる病理学的因子の解釈,とらえ方 招待

    柳井広之

    病理と臨床31 ( 6 ) 623628 - 923   2013年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 軟部腫瘍と分子生物学的解析の臨床応用 特に補助診断法としての有用性について

    国定 俊之, 吉田 晶, 武田 健, 長谷井 嬢, 柳井 広之, 尾崎 敏文

    関節外科32 ( 6 ) 656 - 661   2013年

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  • その平滑筋腫瘍,良性?

    柳井広之

    病理と臨床31 ( 8 ) 922 - 923   2013年

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  • 前立腺癌I-125密封小線源療法におけるネオアジュバント内分泌療法の有用性

    谷本 竜太, 別宮 謙介, 有吉 勇一, 江原 伸, 那須 保友, 公文 裕巳, 柳井 広之, 片山 敬久

    西日本泌尿器科74 ( 10 ) 593 - 593   2012年10月

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    記述言語:日本語   出版者・発行元:西日本泌尿器科学会  

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  • 腋窩の紅色結節

    三宅 智子, 山崎 修, 杉生 真帆, 濱田 利久, 大塚 正樹, 柳井 広之, 森下 佳子, 岩月 啓氏

    日本皮膚病理組織学会会誌27 ( 2 ) 56 - 56   2012年3月

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    記述言語:日本語   出版者・発行元:日本皮膚病理組織学会  

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  • 前立腺癌I-125密封小線源療法におけるネオアジュバント内分泌療法の有用性

    谷本 竜太, 別宮 謙介, 江原 伸, 柳井 広之, 片山 敬久, 那須 保友, 公文 裕巳

    日本泌尿器科学会雑誌103 ( 2 ) 294 - 294   2012年3月

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    記述言語:日本語   出版者・発行元:(一社)日本泌尿器科学会  

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  • A phase I/II study of adenovirus-mediated reduced expression in immortalized cells (REIC/DKK-3) gene therapy for prostate cancer: An interim report.

    Katsumi Sasaki, Yasutomo Nasu, Masami Watanabe, Haruki Kaku, Ryuta Tanimoto, Daiki Kanbara, Toyohiko Watanabe, Hiroyuki Yanai, Hiromi Kumon

    JOURNAL OF CLINICAL ONCOLOGY30 ( 5 )   2012年2月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER SOC CLINICAL ONCOLOGY  

    Web of Science

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  • The impact of neoadjuvant hormone therapy on the permanent I-125-seed brachytherapy for low- or intermediate-risk prostate cancer.

    Ryuta Tanimoto, Kensuke Bekku, Shin Ebara, Motoo Araki, Hiroyuki Yanai, Norihisa Katayama, Yasutomo Nasu, Hiromi Kumon

    JOURNAL OF CLINICAL ONCOLOGY30 ( 5 )   2012年2月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER SOC CLINICAL ONCOLOGY  

    Web of Science

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  • 【卵巣明細胞腺癌と子宮内膜症-分子生物学的アプローチと治療戦略の展望】 子宮内膜症から発生する悪性腫瘍 招待

    柳井広之

    産科と婦人科   2012年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 下大静脈腫瘍塞栓を伴ったCCSK(clear cell sarcoma of the kidney)の1例

    西日本泌尿器科   2012年

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  • 臨床的に悪性を疑った皮膚線維種の一例

    瀧口 徹也, 大塚 正樹, 梅村 啓史, 鈴木 規弘, 青山 裕美, 大野 貴司, 岩月 啓氏, 柳井 広之

    日本皮膚病理組織学会会誌   2012年

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  • 泌尿器がん免疫療法の開発と展望 前立腺癌に対する遺伝子治療 新たな免疫療法の開発をめざした取り組み

    西日本泌尿器科   2012年

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  • 組織亜型分類が困難な卵巣癌 招待

    柳井広之

    日本婦人科病理学会誌3   1 - 5   2012年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 子宮体癌の分類 体癌は分けてもわからない? 招待

    柳井広之

    病理と臨床   2012年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 分節型神経線維腫症に生じた悪性末梢神経鞘腫瘍の1例

    高尾 真理子, 浮田 彩, 竹島 千夏, 鈴木 大介, 大塚 正樹, 白藤 宜紀, 山崎 修, 岩月 啓氏, 柳井 広之, 梅村 茂夫

    日本皮膚科学会雑誌121 ( 11 ) 2277 - 2277   2011年10月

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    記述言語:日本語   出版者・発行元:(公社)日本皮膚科学会  

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  • 分節型神経線維腫症に生じた悪性末梢神経鞘腫瘍の1例

    高尾 真理子, 浮田 彩, 鈴木 大介, 大塚 正樹, 山崎 修, 岩月 啓氏, 柳井 広之, 梅村 茂夫

    日本皮膚科学会雑誌121 ( 10 ) 2087 - 2087   2011年9月

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    記述言語:日本語   出版者・発行元:(公社)日本皮膚科学会  

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  • THE IMPACT OF PATHOLOGICAL REVIEW BY CENTRAL PATHOLOGIST ON SELECTION FOR TREATMENT MODALITY OF LOCALIZED PROSTATE CANCER IN CANDIDATE FOR BRACHYTHERAPY

    R. Kishimoto, T. Saika, K. Bekku, H. Nose, F. Abarzua, Y. Kobayashi, H. Yanai, Y. Nasu, H. Kumon

    EUROPEAN UROLOGY SUPPLEMENTS10 ( 2 ) 115 - 115   2011年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE BV  

    Web of Science

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  • The impact of pathologic review by central pathologist on selection for treatment modality of localized prostate cancer in candidate for brachytherapy

    R. Kishimoto, T. Saika, K. Bekku, H. Nose, F. Abarzua, Y. Kobayashi, H. Yanai, Y. Nasu, H. Kumon

    JOURNAL OF CLINICAL ONCOLOGY29 ( 7 )   2011年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER SOC CLINICAL ONCOLOGY  

    Web of Science

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  • 類内膜性腫瘍 招待

    柳井広之, 吉野 正

    病理と臨床29   830 - 834   2011年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • PP-538 限局性前立腺癌治療における泌尿器病理医による組織学的再評価の有用性についての検討(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

    岸本 涼, 雑賀 隆史, 別宮 謙介, 能勢 宏幸, 小林 泰之, 柳井 広之, 那須 保友, 公文 裕巳

    日本泌尿器科学会雑誌102 ( 2 )   2011年

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    記述言語:日本語   出版者・発行元:一般社団法人 日本泌尿器科学会  

    CiNii Article

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  • Medulloblastoma with extensive nodularityの1例

    柳井広之

    小児がん48 ( 1 ) 60 - 60   2011年

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  • 子宮内膜症から生じる卵巣癌の形態学的特徴 招待

    柳井広之

    日本エンドメトリオーシス学会会誌32   34 - 38   2011年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 血液浄化療法患者の腎細胞癌における臨床的、病理学的検討

    河内 啓一郎, 荒木 元朗, 上原 慎也, 渡邉 豊彦, 雑賀 隆史, 那須 保友, 公文 裕巳, 柳井 広之

    日本透析医学会雑誌43 ( Suppl.1 ) 369 - 369   2010年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • 岡山大学病院におけるI125前立腺癌永久密封小線源療法の治療成績

    上杉 達也, 枝村 康平, 谷本 竜太, 高尾 彰, 小林 泰之, 賀来 春紀, 雑賀 隆史, 那須 保友, 公文 裕巳, 柳井 広之, 武本 充広, 吉尾 浩太郎, 片山 敬久, 小武家 誠, 江原 伸

    日本癌治療学会誌44 ( 2 ) 879 - 879   2009年9月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • 口唇に発生したCystadenomaの1例

    藤井昌江, 片瀬直樹, 玉村 亮, 船越和子, 古谷満寿美, 柳井広之, 長塚 仁

    日本臨床細胞学会岡山支部会誌   2009年

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  • 好酸性変化を伴う濾胞性腫瘍由来と考えられた甲状腺未分化癌の1例

    大原信哉, 井上博文, 那須篤子, 森下由美子, 今井みどり, 松岡博美, 藤田 勝, 柳井広之, 吉野 正

    日本臨床細胞学会岡山支部会誌   2009年

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  • The Bethesda Systemに準拠した子宮頸部細胞診報告−その理論と実践− 理論編

    柳井広之

    日本臨床細胞学会岡山支部会誌   2009年

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  • 切除18ヵ月後に肝転移をきたした径7mmのS状結腸早期癌の1例

    原田馨太, 加藤順, 竹本浩二, 浦岡俊夫, 平岡佐規子, 柳井広之, 山本和秀

    日本消化器病学会雑誌   2009年

  • O14-01 腫瘍径20mm以下, stage IAの肺腺癌の予後におけるBAC componentおよびEGFR遺伝子変異の意義(肺癌4,第25回日本呼吸器外科学会総会)

    小林 成行, 佐野 由文, 豊岡 伸一, 市村 浩一, 柳井 広之, 宗 淳一, 大谷 弘樹, 治田 賢, 山根 正修, 大藤 剛宏

    日本呼吸器外科学会雑誌22 ( 3 )   2008年

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    記述言語:日本語   出版者・発行元:特定非営利活動法人 日本呼吸器外科学会  

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  • 卵巣小細胞癌(高カルシウム血症型) 卵巣小型円形細胞腫瘍の鑑別 招待

    柳井広之, 吉野正

    病理と臨床26   302 - 303   2008年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • IMMUNOHISTOCHEMICAL ANALYSES OF PTPN6 (SHP1) ON LANGERHANS CELL HISTIOCYTOSIS

    Ichiro Murakami, Takashi Oka, Hiaki Sato, Yuta Kitamura, Toshiaki Morito, Katsuyoshi Takata, Yoko Shinno, Masayuki Takano, Kana Washio, Xingang Huang, Maiko Tamura, Naoko Ohnishi, Koichi Ichimura, Yasuharu Sato, Hiroyuki Yanai, Nobuya Ohara, Eisaku Kondo, Kiyoshi Takahashi, Takehiro Tanaka, Jean Gogusev, Francis Jaubert, Akira Morimoto, Shinsaku Imashuku, Tadaatsu Akagi, Tadashi Yoshino

    Proceedings of XXIV Annual Meeting of the Histiocyte Society   2008年

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  • 超音波内視鏡下戦死吸引細胞診が有用であった膵内分泌腫瘍の二例

    井上博文, 藤田勝, 松岡博美, 今井みどり, 森下由美子, 市村浩一, 大森昌子, 大原伸哉, 柳井広之, 松川昭博

    日本臨床細胞学会雑誌47   512   2008年

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  • 新医師臨床研修制度におけるCPC研修の実態 病理担当責任者および臨床研修担当責任者を対象にした日本病理学会中国四国支部アンケート調査

    立山義朗, 万代光一, 安達博信, 亀井敏昭, 柳井広之, 西村理恵子, 羽場礼次, 村上知之, 谷山清己

    病理と臨床26   91 - 97   2008年

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  • 腹水中に腫瘍細胞を認めた乳腺小葉癌の1例

    藤田勝, 松岡博美, 井上博文, 今井みどり, 森下由美子, 大森昌子, 市村浩一, 柳井広之, 大原信哉, 松川昭博

    日本臨床細胞学会岡山支部会誌27   36 - 37   2008年

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  • 乳腺血管肉腫の1例

    松岡博美, 井上博文, 今井みどり, 藤田勝, 森下由美子, 大森昌子, 市村浩一, 柳井広之, 大原信哉, 松川昭博

    日本臨床細胞学会岡山支部会誌27   34 - 35   2008年

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  • Trisomy 21に合併した胸腔内desmoid tumor

    柳井広之, 吉野正

    小児がん45   178   2008年

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  • 唾液腺導管癌の組織型を呈した耳下腺多形腺腫由来癌の1手術例

    松浦博夫, 高田晋一, 江草憲太郎, 南波由紀, 柳井広之

    広島市立広島市民病院医誌24   4 - 7   2008年

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  • 【子宮の病理 子宮体部】 上皮・間質性および間質性腫瘍(平滑筋腫瘍以外)

    柳井広之, 吉野正

    病理と臨床26   380 - 384   2008年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • P-218 病理病期IA,腫瘍径20mm以下の非小細胞肺癌における再発危険因子・予後因子の検討(一般演題(ポスター)23 予後因子1,第48回日本肺癌学会総会号)

    小林 成行, 豊岡 伸一, 市村 浩一, 柳井 広之, 山根 正修, 大藤 剛宏, 佐野 由文, 伊達 洋至

    肺癌47 ( 5 )   2007年10月

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    記述言語:日本語   出版者・発行元:日本肺癌学会  

    CiNii Article

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  • 膀胱と連続性の腹腔内巨大腫瘤として見られたectomesenchymomaの1例.

    小田和歌子, 山鳥一郎, 中原康雄, 後藤隆文, 江口香, 柳井広之

    小児がん43 ( 4 ) 823   2007年

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  • 紡錘形細胞を主体とした甲状腺髄様癌の一例.

    藤田 勝, 井上博文, 松岡博美, 今井みどり, 森下由美子, 市村浩一, 大森昌子, 柳井広之, 大原信哉, 吉野 正

    日本臨床細胞学会岡山支部会誌26   43 - 44   2007年

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  • 超音波内視鏡下膵穿刺吸引細胞診における検体の取扱いとその有用性について.

    井上博文, 藤田 勝, 松岡博美, 今井みどり, 森下由美子, 市村浩一, 大森昌子, 柳井広之, 大原信哉, 吉野 正

    日本臨床細胞学会岡山支部会誌26   45 - 46   2007年

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  • 外陰Merkel cell carcinomaの一症例.

    豊嶋英理子, 関 典子, 中村圭一郎, 本郷淳司, 児玉順一, 平松祐司, 柳井広之, 河本義之, 藤原道久, 高尾 彰, 物部泰昌

    日本臨床細胞学会岡山支部会誌26   13 - 14   2007年

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  • デジタルマイクロスコープを用いた遠隔迅速病理診断.

    柳井広之, 森谷恭子, 大森昌子, 市村浩一, 藤村紀行, 羽原利幸, 櫛田あけみ, 森谷卓也, 園部 宏, 吉野 正

    日本遠隔医療学会雑誌3 ( 2 ) 270 - 271   2007年

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  • 左心房に発生したCalcifying fibrous tumor.

    柳井広之, 市村浩一, 吉野正

    小児がん43 ( 4 ) 818   2007年

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  • 超音波内視鏡下穿刺吸引細胞診が診断に有用であった悪性黒色腫膵転移の一例

    藤田 勝, 今井みどり, 井上博文, 松岡博美, 森下由美子, 市村浩一, 大森昌子, 柳井広之, 大原信哉, 吉野 正

    日本臨床細胞学会岡山支部会誌   2006年

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  • 膵管内乳頭粘液性腺腫の一例

    井上博文, 藤田 勝, 今井みどり, 松岡博美, 森下由美子, 大森昌子, 市村浩一, 大原信哉, 柳井広之, 吉野 正

    日本臨床細胞学会岡山支部会誌   2006年

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  • 移植に伴う肺疾患の病理と病態 招待

    山鳥一郎, 柳井広之, 伊達洋至

    病理と臨床24,963-968   2006年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 乳管洗浄細胞診が診断に有効であった乳癌の一例

    松岡順治, 田淵陽子, 小野亮子, 今田孝子, 梅岡達生, 渡辺直樹, 元木崇之, 松川啓義, 猶本良夫, 田中紀章, 柳井広之, 大森昌子

    岡山医学会雑誌   2006年

  • 卵巣小細胞癌(高カルシウム血症型)の1例

    柳井広之, 木花敏雅, 吉野 正

    小児がん   2006年

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  • 脊索腫と考えられた頭蓋内?鼻腔内腫瘍

    中村聡子, 柳井広之, 田口孝爾, 吉野 正

    小児がん   2006年

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  • 婦人科領域の迅速病理診断のコツと落とし穴 招待

    柳井広之, 吉野 正

    日本婦人科腫瘍学会雑誌23   537 - 542   2005年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 外陰・膣の上皮性悪性腫瘍

    柳井広之

    病理と臨床20   1030 - 1034   2002年

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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▼全件表示

講演・口頭発表等

  • Fumarate hydratase(FH)欠損腎細胞癌によるリンパ節転移に対して、イピリムマブ+ニボルマブ併用療法が奏功した一例

    関戸 崇了, 高本 篤, 小林 泰之, 三井 將雄, 和田里 章吾, 窪田 理沙, 岩田 健宏, 枝村 康平, 佐古 智子, 荒木 元朗, 渡邉 豊彦, 柳井 広之, 那須 保友

    西日本泌尿器科  2019年10月  西日本泌尿器科学会

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    開催年月日: 2019年10月

    記述言語:日本語  

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  • 遠隔再発・遠隔転移をきたした子宮間葉系腫瘍の臨床病理学的検討に関する小委員会報告(病理)

    真田 咲子, 柳井 広之, 三上 芳喜, 大石 善丈, 牛嶋 公生, 小林 裕明, 田代 浩徳, 三上 幹男, 宮本 新吾, 片渕 秀隆

    日本婦人科腫瘍学会雑誌  2019年6月  (公社)日本婦人科腫瘍学会

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    開催年月日: 2019年6月

    記述言語:日本語  

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  • 遠隔再発・遠隔転移を来した子宮間葉系腫瘍の臨床病理学的検討に関する小委員会報告(臨床)

    牛嶋 公生, 三上 幹男, 田代 浩徳, 小林 裕明, 宮本 新吾, 柳井 広之, 三上 芳喜, 大石 善丈, 真田 咲子, 片渕 秀隆

    日本婦人科腫瘍学会雑誌  2019年6月  (公社)日本婦人科腫瘍学会

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    開催年月日: 2019年6月

    記述言語:日本語  

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  • 中枢神経系腫瘍 RELA fusionを伴うependymosarcoma

    柳井 広之, 田中 健大, 田中 顕之, 都地 友紘

    日本小児血液・がん学会雑誌  2018年6月  (一社)日本小児血液・がん学会

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    開催年月日: 2018年6月

    記述言語:日本語  

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  • 子宮頸癌のがん医療の均てん化指標の測定に関する研究

    渡邊 ともね, 神谷 諭, 片渕 秀隆, 加藤 信吾, 金内 優典, 高橋 昌宏, 中井 英勝, 永瀬 智, 新倉 仁, 万代 昌紀, 三上 幹男, 平嶋 泰之, 柳井 広之, 山上 亘, 東 尚弘

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  • NTRK遺伝子融合を有する高悪性度glioneuronal tumorの1例

    黒住 和彦, 中野 嘉子, 石田 穣治, 田中 健大, 土居 正知, 平戸 純子, 吉田 朗彦, 市村 幸一, 柳井 広之, 伊達 勲

    Brain Tumor Pathology  2018年9月 

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  • Midline gliomaの遺伝子変異と長期治療成績の検討

    服部 靖彦, 黒住 和彦, 藤井 謙太郎, 清水 俊彦, 冨田 祐介, 畝田 篤仁, 松本 悠司, 坪井 伸成, 柳井 広之, 伊達 勲

    Brain Tumor Pathology  2018年9月 

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  • 乳児脳室外上衣下巨細胞性星細胞腫の一例

    坪井 伸成, 黒住 和彦, 佐々木 達也, 柳井 広之, 伊達 勲

    Brain Tumor Pathology  2018年9月 

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  • ラブドイド細胞を伴う耳下腺筋上皮癌の一例

    村本 将太, 有安 早苗, 福田 由美子, 中桐 智香子, 山代 承子, 柳井 広之, 渡辺 次郎

    日本臨床細胞学会雑誌  2018年4月 

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  • 当院での超音波内視鏡下穿刺吸引(EUS-FNA)細胞診の診断成績の検討

    野口 裕太郎, 矢吹 満佐江, 清水 哲也, 河田 晶子, 山本 弘基, 谷 祥代, 手島 咲江, 柳井 広之

    日本臨床細胞学会雑誌  2018年4月 

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  • Vater膨大部から発生したmixed adenoneuroendocrine carcinomaの一例

    第106回日本病理学会  2017年 

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  • Biphenotypic sinonasal sarcomaの一例

    第106回日本病理学会  2017年 

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  • ヒト卵巣癌における線維芽細胞の由来

    第106回日本病理学会  2017年 

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  • 子宮頸部液状化細胞診システムCellprep導入に伴う判定成績推移とその要因解析

    第58回日本臨床細胞学会総会  2017年 

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  • 尿細胞診検体処理法の標準化に向けた検討 LBC2法におけるN/C比、核濃度の比較

    第58回日本臨床細胞学会総会  2017年 

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  • 卵管癌肉腫の一例

    第59回日本婦人科腫瘍学会  2017年 

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  • 成人型顆粒膜細胞腫再発に対しレトロゾールを使用した一例

    第59回日本婦人科腫瘍学会  2017年 

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  • 転移、再発を来した子宮筋腫症例の臨床病理学的検討

    第59回日本婦人科腫瘍学会  2017年 

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  • 卵巣成熟奇形腫(MT)摘出術後の再発症例10例の臨床病理学的研究 一施設での長期観察

    第63回日本病理学会秋期総会  2017年 

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  • マイクロサテライト不安定性(MSI)胃癌の組織学的特徴と粘液形質

    第106回日本病理学会  2017年 

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  • 子宮体部に発生したhepatoid carcinomaの1例

    第106回日本病理学会  2017年 

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    第106回日本病理学会  2017年 

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  • 著明な偽血管肉腫様構造を示した乳腺化生癌の1例

    第106回日本病理学会  2017年 

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  • 卵巣原発primitive neuroectodermal-type tumors(PNETs)の一例

    第106回日本病理学会  2017年 

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    第106回日本病理学会  2017年 

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  • 尿細胞診における 尿細管上皮細胞の出方と見方

    第55回日本臨床細胞学会秋期大会  2016年 

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  • 子宮体がん 病態から見た分類と診断

    第58回日本婦人科腫瘍学会  2016年 

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  • Endometrial carcinomas and their precursor lesions

    10th Annual Meeting of Pathology, Jilin Province  2016年 

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  • 子宮体癌の初期病変・前駆病変と「記述式内膜細胞診報告様式」 病理医の見方

    第43回日本婦人科病理学会学術集会  2015年 

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  • 教育講演 子宮内膜癌の組織像と細胞像 細胞診はどこまで組織所見を捉えられるか

    第56回日本臨床細胞学会総会  2015年 

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  • 他科の切り出し作法

    第3回日本泌尿器病理研究会  2014年 

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  • 子宮頸部明細胞腺癌の2症例

    第53回日本婦人科腫瘍学会  2013年 

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  • 粘液上皮化生を示す卵巣子宮内膜症から発生した卵巣明細胞腺癌の一例

    第53回日本婦人科腫瘍学会  2013年 

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  • 10年後に腹壁および大網の一部に再発をきたした卵巣明細胞腺癌の一例

    第53回日本婦人科腫瘍学会  2013年 

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  • 卵巣腫瘍の概念と分類 ーWHO分類第2版までー

    第54回日本婦人科腫瘍学会学術講演会  2013年 

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  • 耳下腺Mammary analogue secretory carcinomaの一例

    第52回日本臨床細胞学会秋期特別総会  2013年 

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  • 膵Soid-pseudopapillary neoplasm(clear cell variant)の一例

    第52回日本臨床細胞学会秋期特別総会  2013年 

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    第53回日本肺癌学会  2013年 

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    熊本産科婦人科学会  2013年 

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    第52回日本臨床細胞学会秋期大会  2013年 

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  • Multilocular cystic patternを呈したXp11.2転座腎細胞癌の一例

    第101回日本病理学会総会  2012年 

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  • 子宮平滑筋肉腫症例の検討

    第52回日本婦人科腫瘍学会  2012年 

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  • ダグラス窩腹膜から発生した異所性甲状腺腫瘍の一例

    第52回日本婦人科腫瘍学会  2012年 

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  • 小児腎腫瘍の外科病理

    第21回日本小児泌尿器科学会 教育講演  2012年 

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    第109回日本病理学会中国四国支部学術集会  2012年 

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    第51回日本臨床細胞学会秋期特別総会  2012年 

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  • 胸水中に腫瘍細胞が出現した縦隔precursor T lymphoblastic lymphomaの1症例

    第51回日本臨床細胞学会秋期特別総会  2012年 

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  • 子宮頸がんの組織学的分類と診断

    第51回日本臨床細胞学会秋期大会  2012年 

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  • 卵巣表層上皮性腫瘍の発生機序

    第53回日本婦人科腫瘍学会 (教育セミナー)  2012年 

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  • 眼房水に浸潤した節外性NK/T細胞リンパ腫、鼻型の一例

    第53回日本臨床細胞学会  2012年 

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  • ASC-H症例の再検討 follow up後SIL、Ca.判定症例の細胞像を検証する

    第53回日本臨床細胞学会  2012年 

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  • 当院で治療した過去10年間の子宮体癌症例の検討 進行type2体癌が増えている

    第52回日本婦人科腫瘍学会  2012年 

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  • 子宮内膜癌の形態学的スペクトラム

    第101回日本病理学会 コンパニオンミーティング  2012年 

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    第101回日本病理学会 教育講演  2012年 

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  • 脳腫瘍に対する治療戦略の新しい展望 基礎的な視点から 悪性神経膠腫におけるCYR61の発現と予後的意義

    第30回日本脳腫瘍病理学会  2012年 

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  • 小児テント上悪性グリオーマにおける予後因子の分子生物学的検討

    第30回日本脳腫瘍病理学会  2012年 

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  • 子宮内膜漿液性腺癌の臨床細胞学的検討

    第53回日本臨床細胞学会  2012年 

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  • 超音波内視鏡下穿刺吸引材料におけるLED透過式検体処理法の検討

    第53回日本臨床細胞学会  2012年 

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  • 甲状腺CASTLEの一例

    第53回日本臨床細胞学会  2012年 

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  • 家族性大腸腺腫症に発生した多発大腸癌で神経内分泌癌への分化や桑実胚様化生を認めた症例

    第101回日本病理学会総会  2012年 

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  • 横紋筋肉腫成分を伴った胸膜悪性中皮腫の一剖検例

    第101回日本病理学会総会  2012年 

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  • 純粋型卵巣原発大細胞神経内分泌癌の一例

    第101回日本病理学会総会  2012年 

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  • 子宮体癌の新しい見方

    岡山細胞検査士会  2012年 

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  • 婦人科疾患の免疫染色

    第1回免疫組織診断セミナー  2012年 

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  • Dysembryoplastic neuroepithelial tumor、complex formの一例

    第101回日本病理学会総会  2012年 

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  • 胃底腺型胃癌(主細胞型、低悪性度)の3例

    第101回日本病理学会総会  2012年 

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  • Barrett腺癌におけるHER2発現の検討

    第101回日本病理学会総会  2012年 

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  • 耳下腺上皮筋上皮癌の一例

    第52回日本臨床細胞学会  2011年 

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  • ベセスダシステム 理論と岡山大学病院での実践経験

    第67回日本臨床細胞学会山口県支部学術集会  2011年 

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  • 子宮体癌 〜これからの組織分類と細胞診〜

    第36回日本臨床細胞学会大阪府支部学術集会  2011年 

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  • 限局性前立腺癌治療における泌尿器病理医による組織学的再評価の有用性についての検討

    第99回日本泌尿器科学会総会  2011年 

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  • 先天性胆道閉鎖症術後にみられた肝限局性結節性過形成(FNH)の一例

    第100回日本病理学会総会  2011年 

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  • 子宮内膜症から生じる卵巣癌の形態学的特徴

    第32回日本エンドメトリオーシス学会  2011年 

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  • 分類困難な卵巣癌

    第35回日本婦人科病理学会  2011年 

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  • 胚細胞腫瘍

    第12回JSAWIシンポジウム  2011年 

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  • 膵臓細胞診における質的診断向上への試み 特殊型膵腫瘍の細胞診像と免疫染色

    第50回日本臨床細胞学会秋期特別総会  2011年 

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  • 破骨細胞型退形成性膵管癌の二例

    第50回日本臨床細胞学会秋期特別総会  2011年 

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  • 病理組織・細胞診セミナー 卵巣腫瘍

    第49回日本臨床細胞学会秋期大会  2011年 

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  • 性索・間質性腫瘍

    日本病理学会秋期総会サテライトセミナー  2011年 

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  • 漿液性腺癌の画像所見とその発生部位について

    第50回日本婦人科腫瘍学会  2011年 

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  • 子宮内膜小細胞癌の一例

    第50回日本婦人科腫瘍学会  2011年 

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  • 免疫組織化学的検討との乖離を呈し、子宮内膜間質肉腫との鑑別を要した子宮平滑筋肉腫の一例

    第50回日本婦人科腫瘍学会  2011年 

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  • 良好な経過を辿ったsolitary fibrous tumorの一例

    第50回日本婦人科腫瘍学会  2011年 

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  • センチネルリンパ節の病理診断 〜乳癌を例として〜

    第50回日本婦人科腫瘍学会  2011年 

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  • 子宮内にびまん性に浸潤する胃型腺癌の一例

    第100回日本病理学会総会  2011年 

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  • 管周囲性の増殖パターンを示す前立腺low grade stromal sarcomaの一例

    第100回日本病理学会総会  2011年 

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  • 神経内分泌腫瘍への分化を示した左頬部汗腺癌の一例

    第100回日本病理学会総会  2011年 

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  • Cellular angiofibromaと考えられた陰嚢内巨大腫瘍の1症例

    第100回日本病理学会総会  2011年 

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  • ASC-US症例の再検討 follow up後SIL判定症例の細胞像を検証する

    第52回日本臨床細胞学会  2011年 

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  • The Bethesda System 理論と実践 理論編

    第27回日本臨床細胞学会岡山県支部会  2009年 

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  • 融合遺伝子を用いた骨・軟部腫瘍診断

    第42回日本整形外科学会 骨・軟部腫瘍学術集会  2009年 

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  • 卵管の病理

    第10回JSAWIシンポジウム  2009年 

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  • 岡山大学病院におけるI125前立腺癌永久密封小線源療法の治療成績

    第47回日本癌治療学会  2009年 

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  • 子宮頸部の神経内分泌腫瘍 —組織分類と細胞像

    第48回日本臨床細胞学会秋期大会  2009年 

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  • 妊娠期に見られた乳腺血管肉腫の1例

    第48回日本臨床細胞学会秋期大会  2009年 

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  • 子宮体部癌の一例

    第46回日本婦人科腫瘍学会  2009年 

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  • LEGHと悪性腺腫の鑑別に苦慮した子宮頸部腫瘍の一例

    第46回日本婦人科腫瘍学会  2009年 

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  • 卵管癌の2症例

    第46回日本婦人科腫瘍学会  2009年 

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  • 組織球性絨毛間腔炎の3例

    第98回日本病理学会総会  2009年 

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  • Mucinous tubular and spindle cell carcinomaの1例

    第98回日本病理学会総会  2009年 

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  • 頭蓋外浸潤性髄膜腫の1例

    第27回日本脳腫瘍病理学会  2009年 

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  • Gangliocytoma成分およびglioma成分両者の広範な浸潤を認めたgangliogliomaの1例

    第27回日本脳腫瘍病理学会  2009年 

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  • 膀胱内進展により自然尿中に腫瘍細胞を認めた乳房外Paget病の1例

    第50回日本臨床細胞学会総会  2009年 

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  • 子宮腫瘍の一例

    第46回日本婦人科腫瘍学会  2009年 

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  • 肺転移をきたした乳腺pseudoangiomatous spindle cell carcinomaの1例

    第16回日本乳癌学会  2008年 

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  • 超音波内視鏡下穿刺吸引細胞診が有用であった膵内分泌腫瘍の2例

    第47回日本臨床細胞学会秋期大会  2008年 

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  • 著明な高カルシウム血症を伴った卵巣小細胞癌の一例

    第44回日本婦人科腫瘍学会  2008年 

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  • 免疫組織学的手法による術前化学療法の効果予測について

    第16回日本乳癌学会  2008年 

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  • 唾液腺腺房細胞癌の二症例

    第49回日本臨床細胞学会総会  2008年 

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  • 膀胱癌を有する女性に生じた外陰Paget病の2例

    第97回日本病理学会総会  2008年 

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  • 大腿軟部に遠隔転移をおこした胃原発gastrointestinal stromal tumorの一例

    第97回日本病理学会総会  2008年 

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  • Malignant solitary fibrous tumorの1剖検例

    第97回日本病理学会総会  2008年 

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  • 気管支腺上皮性乳頭腫の一例

    第97回日本病理学会総会  2008年 

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  • Glioblastoma with oligodendroglioma componentsの3例

    第26回日本脳腫瘍病理学会  2008年 

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  • 脳腫瘍の病理と画像診断 Astrocytomaの悪性度診断 病理所見と画像所見の対比

    第26回日本脳腫瘍病理学会  2008年 

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  • 腫瘍径20mm以下、stage IAの肺腺癌の予後におけるBAC componentおよびEGFR遺伝子変異の意義

    第25回日本呼吸器外科学会総会  2008年 

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  • 超音波内視鏡下穿刺吸引細胞診が有用であった膵solid pseudopapillary tumorの一例

    第46回日本臨床細胞学会秋期大会  2007年 

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  • 超音波内視鏡下膵穿刺吸引細胞診における検体の取り扱いとその有用性について

    第46回日本臨床細胞学会秋期大会  2007年 

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  • 免疫組織学的手法による乳がん術前化学療法の効果予測

    第45回日本癌治療学会  2007年 

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  • 検診発見の肺動静脈瘻を契機に診断されたMicronodular pneumocyte hyperplasia(MNPH)の1例

    第43回日本医学放射線学会秋季臨床大会  2007年 

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  • 超音波内視鏡下穿刺吸引細胞診を行った悪性黒色腫膵転移の2例

    第48回日本臨床細胞学会総会  2007年 

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  • 子宮頚部mesonephric adenocarcinomaの一例

    第42回日本婦人科腫瘍学会  2007年 

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  • Mucinous ovarian adenocarcinoma, endocervical type2例に関する病理学的検討

    第42回日本婦人科腫瘍学会  2007年 

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  • 血清AFP (α-fetoprotein) が高値を示した子宮体癌の症例

    第42回日本婦人科腫瘍学会  2007年 

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  • 過去3年間における術中迅速病理診断477例の検討

    第40回日本整形外科学会骨・軟部腫瘍学術集会  2007年 

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  • 胸腔内腫瘍

    日本病理学会小児腫瘍分類委員会症例検討会  2007年 

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  • デジタルマイクロスコープを用いた遠隔迅速病理診断

    平成19年度日本遠隔医療学会学術大会  2007年 

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  • Homozygous deletions of Pffigene and inactivation of p16 expression in Japanese malignant pleural mesothelioma

    第66回日本癌学会学術総会  2007年 

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  • Nuclear palisadingを伴うDFSPから発生したfibrosarcomaの一例

    第96回日本病理学会総会  2007年 

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  • 気管に発生したGlomus tumorの一症例

    第96回日本病理学会総会  2007年 

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  • 卵巣小細胞癌(高カルシウム血症型) -卵巣小型円形細胞腫瘍の鑑別-

    日本病理学会総会 病理診断講習会  2007年 

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  • 婦人科腫瘍の免疫組織化学 腺系腫瘍を中心に

    日本婦人科病理研究会  2007年 

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  • Prostate ductal carcinoma 5例の腫瘍細胞の性状の免疫組織化学的検討

    第96回日本病理学会総会  2007年 

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  • 下肢に発生したClear cell sarcomaの2例

    第96回日本病理学会総会  2007年 

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  • 肺塞栓症にて死亡した上大静脈原発の血管肉腫の一剖検例

    第96回日本病理学会総会  2007年 

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  • Atypical teratoid rhabdoid tumor(AT/RT)の一例

    2006年 

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  • 肺原発滑膜肉種と考えられた1例

    第42回日本医学放射線学会秋季臨床大会  2006年 

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  • Oligodendrogliomaをベースに悪性化したと考えられたglioblastomaの1例

    第24回日本脳腫瘍病理学会  2006年 

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  • 特異な画像所見、臨床経過を示し、病理学的診断に苦慮した左前頭側頭葉gliomaの1例

    第24回日本脳腫瘍病理学会  2006年 

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  • 腹水中に腫瘍細胞を認めた卵巣adenoendocrine carcinomaの一例

    第45回日本臨床細胞学会総会  2006年 

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  • 骨・軟部腫瘍に対する経皮的針生検法の有用性と限界

    第39回日本整形外科学会 骨・軟部腫瘍学術集会  2006年 

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  • 融合遺伝子を用いた骨・軟部腫瘍診断

    第39回日本整形外科学会 骨・軟部腫瘍学術集会  2006年 

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  • 多発嚢胞性増殖を示した乳腺血管腫の1例

    第14回日本乳癌学会総会  2006年 

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  • PSTTの1症例

    第40回日本婦人科腫瘍学会学術集会  2006年 

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  • 腎転移を生じた下咽頭・食道異時性重複癌症例

    第19回日本口腔・喉頭科学会 学術集会  2006年 

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  • 悪性グリオーマの浸潤パターンと血管新生に関する病理学的検討

    第24回日本脳腫瘍病理学会  2006年 

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  • Ki-67染色標本を用いた核分裂指数の算出と観察者間変動

    第95回日本病理学会総会  2006年 

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  • 乳児脊索腫の一例

    第24回日本脳腫瘍病理学会  2006年 

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  • 前立腺malignant mesenchymomaの1例

    第95回日本病理学会総会  2006年 

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  • 炎症性筋線維芽細胞性腫瘍の一例

    第44回日本臨床細胞学会秋期大会  2006年 

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  • 卵殻状石灰化を伴った胸腺腫の一例

    第42回日本医学放射線学会秋季臨床大会  2006年 

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  • Atypical teratoid/rhabdoid tumorの1例

    第45回日本臨床細胞学会秋季大会  2006年 

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  • メラニン産生性腎癌の1例

    第93回日本泌尿器科学会総会  2005年 

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  • Synovial chondromatosis の軟骨小片内に病巣を認めたclear cell chondrosarcomaの一例

    第94回日本病理学会総会  2005年 

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  • メラニン産生腎細胞癌の一例

    第94回日本病理学会総会  2005年 

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  • 診断・治療が非常に困難であった骨盤内嚢胞性腫瘤の1例

    第38回日本婦人科腫瘍学会学術講演会  2005年 

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  • Gynandroblastomaの1例

    第38回日本婦人科腫瘍学会学術講演会  2005年 

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  • 婦人科領域の迅速病理診断のコツと落とし穴

    第38回日本婦人科腫瘍学会学術講演会  2005年 

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  • Oligodendrogliomaをベースに悪性化したと考えられたglioblastomaの1例

    第10回日本外科病理学会学術総会  2005年 

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  • 乳癌に対する乳房温存手術後の乳房再発再切除例の検討

    第12回日本乳癌学会総会  2004年 

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  • 十二指腸のBrunner腺に発生した腺腫内癌,ならびに腺腫の2手術例の検討

    第93回日本病理学会総会  2004年 

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  • Taxol followed FEC療法による乳癌術前化学療法の臨床病理学的評価

    第12回日本乳癌学会総会  2004年 

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  • Sentinel Node Biopsy(SNB)の適応拡大

    第12回日本乳癌学会総会  2004年 

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  • 著しいリンパ性間質を伴った子宮頚部腺癌

    第34回日本婦人科腫瘍学会学術集会  2003年 

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  • 当院におけるHerceptest 170例の解析

    第92回日本病理学会総会  2003年 

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  • 肺MALT lymphomaの2例

    第44回日本臨床細胞学会総会  2003年 

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▼全件表示

 

担当授業科目

  • 病理病態学 (2020年度) 集中  - その他