Updated on 2023/12/28

写真a

 
Morimoto Daisaku
 
Organization
Okayama University Hospital Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
External link

Degree

  • Ph.D. ( 2021.3   Okayama University )

Research Interests

  • oxidative stress

  • Chronic lung disease

  • Neonatal abstinence syndrome

Research Areas

  • Life Science / Embryonic medicine and pediatrics  / Neonatology

Education

  • Okayama University   大学院医歯薬学総合研究科   小児医科学

    2018.4 - 2021.3

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Research History

  • Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences   Assistant Professor

    2023.4

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  • Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences   clinical fellow

    2018.4 - 2023.3

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Papers

  • Postnatal Longitudinal Analysis of Serum Nitric Oxide and Eosinophil Counts in Extremely Preterm Infants

    Hirokazu Watanabe, Yosuke Washio, Kei Tamai, Daisaku Morimoto, Tomoka Okamura, Junko Yoshimoto, Hidehiko Nakanishi, Misao Kageyama, Atsushi Uchiyama, Hirokazu Tsukahara, Satoshi Kusuda

    Pediatrics & Neonatology   2023.10

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.pedneo.2023.08.006

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  • Shear Wave Dispersionによる後期早産児および正期産新生児の肝臓の粘性の測定

    佐藤 剛史, 渡邉 宏和, 鈴木 健吾, 福田 花奈, 森本 大作, 岡村 朋香, 鷲尾 洋介, 吉本 順子, 塚原 宏一

    日本新生児成育医学会雑誌   35 ( 3 )   545 - 545   2023.10

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    Language：Japanese   Publisher：(公社)日本新生児成育医学会  

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  • 機械学習による血中ビリルビン推定とABO不適合における光線療法基準の評価

    森本 大作, 福田 花奈, 佐藤 剛史, 岡村 朋香, 渡邉 宏和, 鷲尾 洋介, 吉本 順子, 塚原 宏一

    日本周産期・新生児医学会雑誌   59 ( Suppl.1 )   P273 - P273   2023.6

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    Language：Japanese   Publisher：(一社)日本周産期・新生児医学会  

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  • 腕頭動脈から分岐した左総頸動脈より気管孔へ出血した18トリソミーの一例

    椎名 豪, 渡邉 宏和, 福田 花奈, 宮田 将徳, 佐藤 剛史, 森本 大作, 岡村 朋香, 谷本 光隆, 鷲尾 洋介, 尾山 貴徳, 吉本 順子, 塚原 宏一, 野田 卓男

    日本周産期・新生児医学会雑誌   59 ( Suppl.1 )   P421 - P421   2023.6

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    Language：Japanese   Publisher：(一社)日本周産期・新生児医学会  

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  • Longitudinal Measurement of Histidine-Rich Glycoprotein Levels in Bronchopulmonary Dysplasia: A Pilot Study International journal

    Daisaku Morimoto, Yosuke Washio, Kei Tamai, Takeshi Sato, Tomoka Okamura, Hirokazu Watanabe, Yu Fukushima, Junko Yoshimoto, Misao Kageyama, Kenji Baba, Hirokazu Tsukahara

    Biomedicines   11 ( 1 )   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Histidine-rich glycoprotein (HRG) has been reported to inhibit signaling leading to the release of high mobility group box 1 protein, a damage-associated molecular pattern. The present study aimed to determine the longitudinal change in HRG levels in extremely preterm infants and assess whether complications such as bronchopulmonary dysplasia (BPD) were associated with differences in HRG levels. In this multicenter, prospective, observational study, we measured serum HRG levels every 2 weeks from birth to 8 weeks of age. Serum HRG was measured using an enzyme-linked immunosorbent assay. We included 19 extremely preterm infants in the study and 74 samples were analyzed. The median gestational age was 26.0 weeks, and the median birth weight was 858 g. Serum HRG levels showed a significant upward trend after birth (p < 0.001); median HRG concentrations at birth and at 2, 4, 6, and 8 weeks of age were 1.07, 1.11, 2.86, 6.05, and 7.49 µg/mL, respectively. Onset of BPD was not associated with differences in serum HRG levels. Further, the serum HRG levels increased significantly after birth in extremely preterm infants.

    DOI： 10.3390/biomedicines11010212

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  • Prediction model for nonopiate-induced neonatal abstinence syndrome. International journal

    Daisaku Morimoto, Yosuke Washio, Takeshi Sato, Tomoka Okamura, Hirokazu Watanabe, Junko Yoshimoto, Hirokazu Tsukahara

    Pediatrics international : official journal of the Japan Pediatric Society   65 ( 1 )   e15435   2022.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Neonatal abstinence syndrome (NAS) induced by opiate use is common worldwide. While psychiatric drugs are a more common cause of NAS in Japan, infants of mothers taking psychiatric medications do not always develop NAS. The purpose of this study was to develop a practical model for predicting the onset of nonopiate-induced NAS using variables available at birth. METHODS: In this diagnostic study, prediction models were developed using multivariable logistic regression with retrospective data collected at our hospital between 2010 and 2019. NAS diagnosis was based on the Isobe score, and maternal medications were converted to dose equivalents. RESULTS: A total of 164 maternal and infant dyads met the inclusion criteria; 91 were included in the analysis, of whom 29 infants (32%) were diagnosed with NAS. Final models were created with and without the drug indices. The model without the drug indices consisted of neonatal head circumference in z-score and Apgar score at 5 minutes < 9, and the model with the drug indices included these, as well as antipsychotics and hypnotics indices. The C-statistics were 0.747 (95% CI: 0.638-0.856), and 0.795 (95% CI: 0.683-0.907), respectively, indicating good predictive accuracy of NAS onset for the models. CONCLUSIONS: This study developed models that predicted nonopiate-induced NAS with good accuracy, which may be further improved through the use of drug indices.

    DOI： 10.1111/ped.15435

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  • 臍帯ヘルニアと両大血管右室起始症を合併した上腹部Heteropagusの1例

    佐藤 剛史, 鷲尾 洋介, 森本 大作, 渡邉 宏和, 岡村 朋香, 吉本 順子, 塚原 宏一

    日本新生児成育医学会雑誌   34 ( 3 )   501 - 501   2022.10

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    Language：Japanese   Publisher：(公社)日本新生児成育医学会  

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  • Jacobsen症候群・18番染色体長腕部分トリソミーの1例

    福田 花奈, 佐藤 剛史, 森本 大作, 岡村 朋香, 渡邉 宏和, 鷲尾 洋介, 吉本 順子, 塚原 宏一

    日本小児科学会雑誌   126 ( 4 )   722 - 722   2022.4

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    Language：Japanese   Publisher：(公社)日本小児科学会  

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  • Head circumference in infants with nonopiate-induced neonatal abstinence syndrome. International journal

    Daisaku Morimoto, Yosuke Washio, Kazuki Hatayama, Tomoka Okamura, Hirokazu Watanabe, Junko Yoshimoto, Hirokazu Tsukahara

    CNS spectrums   26 ( 5 )   509 - 512   2021.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Cambridge University Press ({CUP})  

    BACKGROUND: No relationship has been reported between nonopiate neonatal abstinence syndrome (NAS) and anthropometric indices, including head circumference (HC). The purpose of this study was to determine the relationship between maternal nonopioid drug use and HC at birth in neonates with NAS. METHODS: This retrospective observational study included neonates born between January 1, 2010 and March 31, 2019, whose mothers had been taking antipsychotic, antidepressant, sedative, or anticonvulsant medications. The outcome measures were HCs of NAS infants and controls. RESULTS: Of 159 infants, 33 (21%) were diagnosed with NAS. There was no maternal opioid use among mothers during pregnancy. The HCs in the NAS group were significantly smaller than those in the control group. The median z-scores for HC at birth were -0.20 and 0.29 in the NAS group and the control group, respectively (P = .011). The median HCs at birth were 33.0 and 33.5 cm in the NAS group and the control group, respectively. Multivariate analysis revealed that maternal antipsychotic drug use and selective serotonin reuptake inhibitors were independently associated with NAS (P < .001 and P = .004, respectively). Notably, benzodiazepine use and smoking were not independent risk factors. CONCLUSIONS: The results suggest an association between maternal antipsychotic drug use and NAS, which was further associated with decreased HC. Careful monitoring of maternal drug use should be considered to improve fetal outcomes.

    DOI： 10.1017/S1092852920001522

    PubMed

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