Faculty Profiles - Fukushima Yosuke

写真a

Fukushima Yosuke

Organization

Faculty of Medicine, Dentistry and Pharmaceutical Sciences Special-Appointment Associate Professor

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Degree

Doctor of Philosophy ( 2019.12 Okayama University )

Research Interests

先天性心疾患

Education

岡山大学大学院総合研究科（小児医科学専攻）

2015.4 - 2019.12

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Wakayama Medical University 医学部医学科

2003.4 - 2009.3

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Papers

Morphological evaluation for the narrowest section of the patent ductus arteriosus in infants by CT: a crucial point for device closure

Yosuke Fukushima, Naomi Nakagawa, Masahiro Kamada, Kengo Okamoto, Hitoshi Uemasu, Koichi Kataoka

Cardiology in the Young 2024.9

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DOI： 10.1017/S104795112402523X

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Pulmonary Flow Management by Combination Therapy of Hemostatic Clipping and Balloon Angioplasty for Right Ventricular-Pulmonary Artery Shunt in Hypoplastic Left Heart Syndrome. International journal

Yusuke Shigemitsu, Maiko Kondo, Yoshihiko Kurita, Yosuke Fukushima, Yuya Kawamoto, Kenta Hirai, Mayuko Hara, Tomoyuki Kanazawa, Tatsuo Iwasaki, Shingo Kasahara, Koichi Kataoka, Hirokazu Tsukahara, Kenji Baba

Pediatric cardiology 2024.7

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Controlling pulmonary blood flow in patients who have undergone Norwood palliation, especially early postoperatively, is challenging due to a change in the balance of systemic and pulmonary vascular resistance. We applied a combination therapy of clipping and balloon angioplasty for right ventricle-pulmonary artery (RV-PA) shunt to control pulmonary blood flow, but the influence of the combination therapy on the PA condition is uncertain. Retrospectively analysis was conducted of all infants with hypoplastic left heart syndrome who had undergone Norwood palliation with RV-PA shunt at Okayama University Hospital from January 2008 to September 2022. A total of 50 consecutive patients underwent Norwood palliation with RV-PA shunt in this study period. Of them, 29 patients underwent RV-PA shunt flow clipping, and the remaining 21 had unclipped RV-PA shunt. Twenty-three patients underwent balloon angioplasty for RV-PA shunt with clips. After balloon angioplasty, oxygen saturation significantly increased from 69 (59-76)% to 80 (72-86)% (p < 0.001), and the narrowest portion of the clipped conduit significantly improved from 2.8 (1.8-3.4) to 3.8 (2.9-4.6) mm (p < 0.001). In cardiac catheterizations prior to Bidirectional cavo-pulmonary shunt (BCPS), there were no significant differences in pulmonary-to-systemic flow ratio (Qp/Qs), ventricular end-diastolic pressure, Nakata index, arterial saturation, mean pulmonary artery pressure and pulmonary vascular resistance index. On the other hand, in Cardiac catheterizations prior to Fontan, Nakata index was larger in the clipped group (p = 0.02). There was no statistically significant difference in the 5-year survival between the two groups (clipped group 96%, unclipped group 74%, log-rank test: p = 0.13). At least, our combination therapy of clipping and balloon angioplasty for RV-PA shunt did not negatively impact PA growth. Although there is a trend toward better but not statistically significant difference in outcomes in the clipped group compared to the non-clipped group, this treatment strategy may play an important role in improving outcomes in hypoplastic left heart syndrome.

DOI： 10.1007/s00246-024-03579-6

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当科での成人期複雑心奇形に対するカテーテル治療

馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 川本祐也, 原真佑子, 赤木禎治, 西井伸洋, 杜徳尚, 小谷恭弘, 笠原真悟

日本成人先天性心疾患学会雑誌 13 ( 1 ) 125 - 125 2024.1

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移行期医療・ACHD診療の実践的方策移行期医療を断念せざるを得ない患者について考える

馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 川本祐也, 原真佑子, 赤木禎治, 西井伸洋, 杜徳尚, 川畑拓也, 黒子洋介, 小谷恭弘, 笠原真悟

日本成人先天性心疾患学会雑誌 13 ( 1 ) 91 - 91 2024.1

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Epilepsy in Children With Congenital Heart Disease: Risk Factors and Characteristic Presentations. International journal

Takashi Shibata, Maiko Kondo, Yosuke Fukushima, Mari Akiyama, Tomoyuki Akiyama, Teruko Morooka, Kenji Baba, Shinichi Ohtsuki, Hirokazu Tsukahara, Shingo Kasahara, Katsuhiro Kobayashi

Pediatric neurology 147 28 - 35 2023.10

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BACKGROUND: Children with a congenital heart disease (CHD) are at a higher risk of developing epilepsy than the general population, but detailed characteristics of CHD-associated epilepsy have not been clarified. The purposes of this study were to determine the risk factors for developing epilepsy associated with CHD and to elucidate the characteristics of such epilepsy. METHODS: We performed a retrospective cohort study based on medical records of pediatric patients with CHD who were born between January 2006 and December 2016, underwent cardiac surgery at Okayama University Hospital, and were followed up until at least age three years. Multivariate logistic regression analysis was used to determine factors particularly associated with epilepsy occurrence. In patients who developed epilepsy, clinical data on seizure characteristics were further investigated. RESULTS: We collected data from 1024 patients, and 41 (4.0%) developed epilepsy. The presence of underlying disease (odds ratio [OR]: 2.413; 95% confidence interval [CI]: 1.150 to 4.883) and the Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery score category 2 (OR: 4.373; 95% CI: 1.090 to 29.150) and category 5 (OR: 10.385; 95% CI: 1.717 to 89.016) were significantly related to epilepsy occurrence. Of the 41 patients with epilepsy, 15 (including nine with hypoplastic left heart syndrome) had focal impaired awareness seizures specified as autonomic seizures with vomiting, which tends to escape detection. CONCLUSIONS: We clarified the risk factors for developing epilepsy in children with CHD. We also found that autonomic seizure with vomiting is an important symptom in these children.

DOI： 10.1016/j.pediatrneurol.2023.07.004

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Challenging cases in interventional cardiology カテーテル的肺静脈ステント留置術の留意点

馬場健児, 栗田佳彦, 近藤麻衣子, 重光祐輔, 福嶋遥佑, 川本祐也, 原真祐子, 岩崎達雄, 金澤伴幸, 小谷泰弘, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [I - 06] 2023.7

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先天性心疾患術後に施行した冠動脈領域に対する介入についての検討評価・適応について

栗田佳彦, 馬場健児, 近藤麻衣子, 重光祐輔, 福嶋遥佑, 原真祐子, 平井健太, 大月審一, 塚原宏一, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [I - 02] 2023.7

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大動脈離断/心室中隔欠損症の術後遠隔期の検討

福嶋遥佑, 大月審一, 馬場健児, 近藤麻衣子, 栗田佳彦, 重光祐輔, 平井健太, 原真祐子, 岩崎達雄, 笠原真悟, 小谷恭弘

日本小児循環器学会総会・学術集会抄録集 59回 [II - 06] 2023.7

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大動脈-左室トンネル(Aorto-left ventricular tunnel)の外科治療と遠隔期の問題点

原真祐子, 馬場健児, 近藤麻衣子, 栗田佳彦, 重光祐輔, 福嶋遥佑, 大月審一, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [I - 01] 2023.7

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PVstent治療のその先、より大きなサイズへのstent replacement

近藤麻衣子, 馬場健児, 栗田佳彦, 福嶋遥佑, 重光祐輔, 平井健太, 川本祐也, 原真祐子, 笠原真悟, 大月審一

日本小児循環器学会総会・学術集会抄録集 59回 [I - 02] 2023.7

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治療を希望しない胎児先天性心疾患症例に対する小児循環器科医の対応はどうあるべきか? 治療拒否家族への対応としての緊急院内倫理委員会開催の意義

馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 重光祐輔, 川本祐也, 原真祐子, 早田圭, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [III - 04] 2023.7

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フォンタン適応獲得を目指した再手術 Fontan適応獲得に向けたCRTの有用性

重光祐輔, 馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 平井健太, 原真祐子, 大月審一, 笠原真悟, 栄徳隆裕

日本小児循環器学会総会・学術集会抄録集 59回 [I - 05] 2023.7

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Stepwise Treatment for Heterotaxy Syndrome and Functional Single Ventricle Complicated by Infra-Cardiac Total Anomalous Pulmonary Venous Connection with Ductus Venosus Stent Placement and Subsequent Occlusion. International journal

Yuki Imai, Kenji Baba, Shinichi Otsuki, Maiko Kondo, Takahiro Eitoku, Yusuke Shigemitsu, Yosuke Fukushima, Kenta Hirai, Tatsuo Iwasaki, Tomoyuki Kanazawa, Yasuhiro Kotani, Shingo Kasahara

Pediatric cardiology 43 ( 4 ) 756 - 763 2022.4

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Even today, when the surgical outcome of congenital heart disease in the neonatal period has improved, the prognosis for heterotaxy syndrome and functional single ventricle complicated with total anomalous pulmonary venous connection (TAPVC), especially the infra-cardiac type, is catastrophic. We describe a strategy that combines percutaneous ductus venosus (DV) stent placement and occlusion after TAPVC repair to ensure survival from initial surgery to bidirectional cavopulmonary shunt (BCPS) procedure and facilitate subsequent treatment. Three consecutive patients with heterotaxy syndrome and functional single ventricle complicated by infra-cardiac TAPVC treated with our own strategy were retrospectively studied. In two infants, DV stent placement was performed on the day of birth. In one case at 11 days of age. The risk of pulmonary vein obstruction was reduced, and on-pump surgery, including TAPVC repair, was performed on a standby basis. Since the rapid increase in hepatic enzymes occurred on postoperative day 0 to 1 in all cases, percutaneous stent occlusion was performed until postoperative day 3. The procedure improved liver function. One patient died due to severe atrioventricular valve regurgitation, one case underwent BCPS, and one patient was waiting to undergo. DV stent placement can avoid TAPVC repair in the early neonatal period. After TAPVC repair, the portosystemic shunt remained, resulting in hepatic dysfunction, but this could be improved by stent and vertical vein occlusion. A series of stepwise treatments can be useful to help such critically ill infants survive the high-risk neonatal period and achieve good BCPS circulation.

DOI： 10.1007/s00246-021-02782-z

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Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy. International journal

Kenta Hirai, Daiki Ousaka, Yosuke Fukushima, Maiko Kondo, Takahiro Eitoku, Yusuke Shigemitsu, Mayuko Hara, Kenji Baba, Tatsuo Iwasaki, Shingo Kasahara, Shinichi Ohtsuki, Hidemasa Oh

Science translational medicine 12 ( 573 ) 2020.12

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Although cardiosphere-derived cells (CDCs) improve cardiac function and outcomes in patients with single ventricle physiology, little is known about their safety and therapeutic benefit in children with dilated cardiomyopathy (DCM). We aimed to determine the safety and efficacy of CDCs in a porcine model of DCM and translate the preclinical results into this patient population. A swine model of DCM using intracoronary injection of microspheres created cardiac dysfunction. Forty pigs were randomized as preclinical validation of the delivery method and CDC doses, and CDC-secreted exosome (CDCex)-mediated cardiac repair was analyzed. A phase 1 safety cohort enrolled five pediatric patients with DCM and reduced ejection fraction to receive CDC infusion. The primary endpoint was to assess safety, and the secondary outcome measure was change in cardiac function. Improved cardiac function and reduced myocardial fibrosis were noted in animals treated with CDCs compared with placebo. These functional benefits were mediated via CDCex that were highly enriched with proangiogenic and cardioprotective microRNAs (miRNAs), whereas isolated CDCex did not recapitulate these reparative effects. One-year follow-up of safety lead-in stage was completed with favorable profile and preliminary efficacy outcomes. Increased CDCex-derived miR-146a-5p expression was associated with the reduction in myocardial fibrosis via suppression of proinflammatory cytokines and transcripts. Collectively, intracoronary CDC administration is safe and improves cardiac function through CDCex in a porcine model of DCM. The safety lead-in results in patients provide a translational framework for further studies of randomized trials and CDCex-derived miRNAs as potential paracrine mediators underlying this therapeutic strategy.

DOI： 10.1126/scitranslmed.abb3336

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Balloon atrial septostomy in hypoplastic left heart syndrome with restrictive atrial septum. International journal

Yosuke Fukushima, Kenji Baba, Maiko Kondo, Yoshihiko Kurita, Takahiro Eitoku, Yusuke Shigemitsu, Kenta Hirai, Hirokazu Tsukahara, Tatsuo Iwasaki, Shingo Kasahara, Yasuhiro Kotani, Shinichi Otsuki

Pediatrics international : official journal of the Japan Pediatric Society 61 ( 4 ) 339 - 344 2019.4

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BACKGROUND: Rashkind balloon atrial septostomy (BAS) can be challenging in infants with hypoplastic left heart syndrome (HLHS) and small atrial septal defect (ASD). METHODS: We retrospectively reviewed all infants with HLHS who underwent surgery and BAS between January 2006 and December 2015. The infants were divided into three groups: no BAS; catheter BAS; and open AS. Infants who underwent catheter BAS were divided into two groups based on atrial septal anatomy: standard and complex. RESULTS: Of the 70 patients, 57 (81%) underwent Glenn surgery. Subsequently, a significant difference in survival was observed: 86% (44/51), 91% (10/11), and 25% (2/8) in the no BAS, catheter BAS, and open AS groups, respectively (P = 0.0002). No significant difference was seen between the no BAS and the catheter BAS groups (P = 1.0). In the 56 patients who underwent catheterization after surgery, no intergroup differences in mean pulmonary artery pressure, pulmonary vascular resistance, or pulmonary artery index were found. We classified catheter BAS into standard (n = 5) and complex (n = 5) based on ASD location, and septum thickness. All patients in the standard group underwent complete Rashkind BAS, but in the complex group, only one patient underwent complete Rashkind BAS, with the remaining requiring initial static BAS (P = 0.048). Following septostomy, ASD size, ASD flow, and percutaneous oxygen saturation (SpO2 ) were not significantly different between the two groups. CONCLUSIONS: Catheter BAS is effective in infants with HLHS and a restrictive atrial septum. Infants with standard or complex atrial septum can achieve equivalent outcomes despite more patients often requiring static BAS.

DOI： 10.1111/ped.13716

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Arrhythmia risk and β-blocker therapy in pregnant women with long QT syndrome. International journal

Kohei Ishibashi, Takeshi Aiba, Chizuko Kamiya, Aya Miyazaki, Heima Sakaguchi, Mitsuru Wada, Ikutaro Nakajima, Koji Miyamoto, Hideo Okamura, Takashi Noda, Toshifumi Yamauchi, Hideki Itoh, Seiko Ohno, Hideki Motomura, Yoshiharu Ogawa, Hiroko Goto, Takaomi Minami, Nobue Yagihara, Hiroshi Watanabe, Kanae Hasegawa, Akihiro Terasawa, Hitoshi Mikami, Kayo Ogino, Yukiko Nakano, Sato Imashiro, Yosuke Fukushima, Yoshimitsu Tsuzuki, Koko Asakura, Jun Yoshimatsu, Isao Shiraishi, Shiro Kamakura, Yoshihiro Miyamoto, Satoshi Yasuda, Takashi Akasaka, Minoru Horie, Wataru Shimizu, Kengo Kusano

Heart (British Cardiac Society) 103 ( 17 ) 1374 - 1379 2017.9

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BACKGROUND: Pregnancy is one of the biggest concerns for women with long QT syndrome (LQTS). OBJECTIVES: This study investigated pregnancy-related arrhythmic risk and the efficacy and safety of β-blocker therapy for lethal ventricular arrhythmias in pregnant women with LQTS (LQT-P) and their babies. METHODS: 136 pregnancies in 76 LQT-P (29±5 years old; 22 LQT1, 36 LQT2, one LQT3, and 17 genotype-unknown) were enrolled. We retrospectively analysed their clinical and electrophysiological characteristics and pregnancy outcomes in the presence (BB group: n=42) or absence of β-blocker therapy (non-BB group: n=94). RESULTS: All of the BB group had been diagnosed with LQTS with previous events, whereas 65% of the non-BB group had not been diagnosed at pregnancy. Pregnancy increased heart rate in the non-BB group; however, no significant difference was observed in QT and Tpeak-Tend intervals between the two groups. In the BB group, only two events occurred at postpartum, whereas 12 events occurred in the non-BB group during pregnancy (n=6) or postpartum period (n=6). The frequency of spontaneous abortion did not differ between the two groups. Fetal growth rate and proportion of infants with congenital malformation were similar between the two groups, but premature delivery and low birthweight infants were more common in those taking BB (OR 4.79, 95% CI 1.51 to 15.21 and OR 3.25, 95% CI 1.17 to 9.09, respectively). CONCLUSIONS: Early diagnosis and β-blocker therapy for high-risk patients with LQTS are important for prevention of cardiac events during pregnancy and the postpartum period, and β-blocker therapy may be tolerated for babies in LQT-P cases.

DOI： 10.1136/heartjnl-2016-310617

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重篤な低酸素血症のため緊急避難的に冠動脈用stentを留置した肺動脈低形成を伴うPA/VSD、MAPCAの2例

馬場健児, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 重光祐輔, 平井健太, 福嶋遙佑, 岩崎達雄, 笠原真悟, 佐野俊二, 大月審一

日本小児循環器学会雑誌 33 ( Suppl.1 ) s1 - 348 2017.7

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Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology: The PERSEUS (Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease) Randomized Phase 2 Trial. International journal

Shuta Ishigami, Shinichi Ohtsuki, Takahiro Eitoku, Daiki Ousaka, Maiko Kondo, Yoshihiko Kurita, Kenta Hirai, Yosuke Fukushima, Kenji Baba, Takuya Goto, Naohiro Horio, Junko Kobayashi, Yosuke Kuroko, Yasuhiro Kotani, Sadahiko Arai, Tatsuo Iwasaki, Shuhei Sato, Shingo Kasahara, Shunji Sano, Hidemasa Oh

Circulation research 120 ( 7 ) 1162 - 1173 2017.3

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RATIONALE: Patients with single ventricle physiology are at high risk of mortality resulting from ventricular dysfunction. The preliminary results of the phase 1 trial showed that cardiosphere-derived cells (CDCs) may be effective against congenital heart failure. OBJECTIVE: To determine whether intracoronary delivery of autologous CDCs improves cardiac function in patients with single ventricle physiology. METHODS AND RESULTS: We conducted a phase 2 randomized controlled study to assign in a 1:1 ratio 41 patients who had single ventricle physiology undergoing stage 2 or 3 palliation to receive intracoronary infusion of CDCs 4 to 9 weeks after surgery or staged reconstruction alone (study A). The primary outcome measure was to assess improvement in cardiac function at 3-month follow-up. Four months after palliation, controls had an alternative option to receive late CDC infusion on request (study B). Secondary outcomes included ventricular function, heart failure status, somatic growth, and health-related quality of life after a 12-month observation. At 3 months, the absolute changes in ventricular function were significantly greater in the CDC-treated group than in the controls (+6.4% [SD, 5.5] versus +1.3% [SD, 3.7]; P=0.003). In study B, a late CDC infusion in 17 controls increased the ventricular function at 3 months compared with that at baseline (38.8% [SD, 7.7] versus 34.8% [SD, 7.4]; P<0.0001). At 1 year, overall CDC infusion was associated with improved ventricular function (41.4% [SD, 6.6] versus 35.0% [SD, 8.2]; P<0.0001) and volumes (P<0.001), somatic growth (P<0.0001) with increased trophic factors production, such as insulin-like growth factor-1 and hepatocyte growth factor, and quality of life, along with a reduced heart failure status (P<0.0001) and cardiac fibrosis (P=0.014) relative to baseline. CONCLUSIONS: Intracoronary infusion of CDCs after staged palliation favorably affected cardiac function by reverse remodeling in patients with single ventricle physiology. This impact may improve heart failure status, somatic growth, and quality of life in patients and reduce parenting stress for their families. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01829750.

DOI： 10.1161/CIRCRESAHA.116.310253

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成人先天性疾患に対するカテーテル治療成人期のSingle Ventricle PhysiologyにおけるCatheter Interventionの役割

馬場健児, 大月審一, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 重光祐輔, 福嶋遙佑, 平井健太, 佐野俊二, 笠原真悟, 岩崎達雄

日本小児循環器学会雑誌 31 ( Suppl.1 ) s1 - 130 2015.7

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治療を希望しない胎児先天性心疾患症例に対する小児循環器科医の対応はどうあるべきか? 治療拒否家族への対応としての緊急院内倫理委員会開催の意義

馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 重光祐輔, 川本祐也, 原真祐子, 早田圭, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [III - 04] 2023.7

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大動脈-左室トンネル(Aorto-left ventricular tunnel)の外科治療と遠隔期の問題点

原真祐子, 馬場健児, 近藤麻衣子, 栗田佳彦, 重光祐輔, 福嶋遥佑, 大月審一, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [I - 01] 2023.7

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フォンタン適応獲得を目指した再手術 Fontan適応獲得に向けたCRTの有用性

重光祐輔, 馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 平井健太, 原真祐子, 大月審一, 笠原真悟, 栄徳隆裕

日本小児循環器学会総会・学術集会抄録集 59回 [I - 05] 2023.7

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PVstent治療のその先、より大きなサイズへのstent replacement

近藤麻衣子, 馬場健児, 栗田佳彦, 福嶋遥佑, 重光祐輔, 平井健太, 川本祐也, 原真祐子, 笠原真悟, 大月審一

日本小児循環器学会総会・学術集会抄録集 59回 [I - 02] 2023.7

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Challenging cases in interventional cardiology カテーテル的肺静脈ステント留置術の留意点

馬場健児, 栗田佳彦, 近藤麻衣子, 重光祐輔, 福嶋遥佑, 川本祐也, 原真祐子, 岩崎達雄, 金澤伴幸, 小谷泰弘, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [I - 06] 2023.7

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大動脈離断/心室中隔欠損症の術後遠隔期の検討

福嶋遥佑, 大月審一, 馬場健児, 近藤麻衣子, 栗田佳彦, 重光祐輔, 平井健太, 原真祐子, 岩崎達雄, 笠原真悟, 小谷恭弘

日本小児循環器学会総会・学術集会抄録集 59回 [II - 06] 2023.7

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先天性心疾患術後に施行した冠動脈領域に対する介入についての検討評価・適応について

栗田佳彦, 馬場健児, 近藤麻衣子, 重光祐輔, 福嶋遥佑, 原真祐子, 平井健太, 大月審一, 塚原宏一, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [I - 02] 2023.7

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肺高血圧の新しい機序肺炎に伴う組織変化とリンパ節腫大による肺静脈圧迫

片岡功一, 中川直美, 福嶋遥佑, 岡本健吾, 上桝仁志, 鎌田政博, 川田典子, 久持邦和, 立石篤史

日本小児循環器学会総会・学術集会抄録集 58回 [I - 10] 2022.7

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グレン手術後の付加的肺血流の効果

福嶋遥佑, 中川直美, 岡本健吾, 上桝仁志, 片岡功一, 鎌田政博, 久持邦和, 立石篤史

日本小児循環器学会総会・学術集会抄録集 58回 [II - 04] 2022.7

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心筋症における心電図の意義を見直す学校心臓検診の心電図異常を契機に診断された心筋症の臨床像と診断の問題点

上桝仁志, 中川直美, 岡本健吾, 福嶋遥佑, 片岡功一, 鎌田政博

日本小児循環器学会総会・学術集会抄録集 58回 [II - 03] 2022.7

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経皮的ASD/PFO閉鎖術での安全な留置と被爆低減の両立を目指して

岡本健吾, 中川直美, 片岡功一, 福嶋遥佑, 鎌田政博

日本小児循環器学会総会・学術集会抄録集 58回 [III - 11] 2022.7

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肺炎と間違いやすい危急的速やかに対応が必要な疾患

福嶋遥佑, 中川直美, 岡本健吾, 上枡仁志, 鎌田政博, 片岡功一

日本小児科学会雑誌 126 ( 6 ) 994 - 994 2022.6

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体重2～5kgの動脈管に対するカテーテル治療の現状

中川直美, 福嶋遥佑, 岡本健吾, 上桝仁志, 鎌田政博, 片岡功一

広島医学 75 ( 5 ) 233 - 233 2022.5

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無症状で成人に至った重複大動脈弓

上桝仁志, 中川直美, 福嶋遥佑, 岡本健吾, 鎌田政博, 片岡功一, 久持邦和, 立石篤志

日本成人先天性心疾患学会雑誌 11 ( 1 ) 269 - 269 2022.1

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ACHD患者をどのようにCOVID-19から守るか?当院でのワクチン接種への取り組み

福嶋遥佑, 中川直美, 岡本健吾, 上桝仁志, 鎌田政博, 片岡功一

日本成人先天性心疾患学会雑誌 11 ( 1 ) 198 - 198 2022.1

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35mmを超える閉鎖栓を要した成人ASD症例の特徴と治療戦略限界症例に挑む

片岡功一, 中川直美, 福嶋遥佑, 岡本健吾, 鎌田政博, 臺和興, 兵頭洋平, 西岡健司

日本成人先天性心疾患学会雑誌 11 ( 1 ) 188 - 188 2022.1

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成人PDAの形態的特徴と至適デバイスの選び方

中川直美, 福嶋遥佑, 岡本健吾, 上桝仁志, 鎌田政博, 片岡功一

日本成人先天性心疾患学会雑誌 11 ( 1 ) 188 - 188 2022.1

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両側肺動脈絞扼(bPAB)からの二心室修復両側肺動脈絞扼術後LV recruitmentにより二心室修復を施行し得た左心低形成症例の検討

重光祐輔, 馬場健児, 近藤麻衣子, 栄徳隆裕, 福嶋遥佑, 平井健太, 原真祐子, 大月審一, 岩崎達雄, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 57回 [II - 8] 2021.7

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当院における小児に対する開胸下CRTの有用性

栄徳隆裕, 大月審一, 馬場健児, 近藤麻衣子, 福嶋遥佑, 重光祐輔, 平井健太, 笠原真悟, 小谷恭介, 川畑拓也, 原真祐子

日本小児循環器学会総会・学術集会抄録集 57回 [P30 - 6] 2021.7

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肺静脈狭窄症に対するstent治療の効果と経過の検討

福嶋遥佑, 大月審一, 馬場健児, 近藤麻衣子, 栄徳隆裕, 重光祐輔, 平井健太, 原真祐子, 笠原真悟, 小谷恭弘, 岩崎達雄

日本小児循環器学会総会・学術集会抄録集 57回 [OR6 - 3] 2021.7

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大動脈離断・心室中隔欠損症例における術後LVOTSを回避するための術式選択

近藤麻衣子, 馬場健児, 栄徳隆裕, 重光祐輔, 福嶋遥佑, 平井健太, 原真佑子, 大月審一, 笠原真悟, 岩崎達雄

日本小児循環器学会総会・学術集会抄録集 57回 [OR6 - 2] 2021.7

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両側肺動脈絞扼術後、遠隔期肺動脈狭窄病変の残存の検討

福嶋遥佑, 大月審一, 馬場健児, 近藤麻衣子, 栄徳隆裕, 重光祐輔, 平井健太, 笠原真悟, 小谷恭弘, 黒子洋介, 岩崎達雄

日本小児循環器学会雑誌 36 ( Suppl.2 ) s2 - 336 2020.11

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failing Fontan症例に対するfenestration作成術

馬場健児, 近藤麻衣子, 栄徳隆裕, 今井祐喜, 福嶋遥佑, 重光祐輔, 平井健太, 大月審一, 笠原真悟, 岩崎達雄

日本小児循環器学会雑誌 36 ( Suppl.2 ) s2 - 236 2020.11

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純型肺動脈閉鎖における冠動脈右室瘻の分類

栄徳隆裕, 大月審一, 馬場健児, 近藤麻衣子, 今井祐喜, 福嶋遥佑, 重光祐輔, 平井健太, 笠原真悟, 小谷恭介

日本小児循環器学会雑誌 36 ( Suppl.2 ) s2 - 151 2020.11

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胎児心臓病学「胎児治療へつなぐ先天性心疾患の胎児診断」 HLHSにおける胎児期肺静脈血流パターン別の臨床像と予後

近藤麻衣子, 馬場健児, 栄徳隆裕, 今井祐喜, 重光祐輔, 福嶋遥佑, 平井健太, 大月審一, 笠原真悟, 岩崎達雄

日本小児循環器学会雑誌 36 ( Suppl.2 ) s2 - 143 2020.11

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新しい手術方法の開発「治療から再生へ-再生医療の進歩」小児心不全に対する再生医療のUpdate

平井健太, 大月審一, 馬場健児, 近藤麻衣子, 栄徳隆裕, 福嶋遥佑, 重光祐輔, 原真祐子, 笠原真悟, 王英正

日本小児循環器学会雑誌 36 ( Suppl.2 ) s2 - 114 2020.11

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大動脈離断症の左室流出路狭窄に対する二心室修復適応

今井祐喜, 大月審一, 馬場健児, 近藤麻衣子, 栄徳隆裕, 重光祐輔, 福嶋遥佑, 平井健太, 原真祐子, 小林優

日本小児循環器学会雑誌 35 ( Suppl.1 ) s1 - 332 2019.6

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この症例をどうするか?:カテーテル治療近接する左上下肺静脈狭窄に対してfenestration stent経由でstent留置を施行したフォンタン術後症例

馬場健児, 近藤麻衣子, 栄徳隆裕, 今井祐喜, 重光祐輔, 福嶋遥佑, 平井健太, 原真祐子, 大月審一

日本小児循環器学会雑誌 35 ( Suppl.1 ) s1 - 149 2019.6

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当施設におけるCRTの有用性の検討

重光祐輔, 大月審一, 馬場健児, 近藤麻衣子, 栄徳隆裕, 今井祐喜, 福嶋遥佑, 平井健太, 原真祐子, 小林優, 笠原真悟

日本小児循環器学会雑誌 35 ( Suppl.1 ) s1 - 106 2019.6

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左室内非同期と心室間非同期を伴い、左室駆出率が低下したB型顕性WPW症候群にカテーテルアブレーションを行なうと、心機能が回復する

栄徳隆裕, 大月審一, 馬場健児, 近藤麻衣子, 今井祐喜, 福嶋遥佑, 重光祐輔, 平井健太, 小林優

日本小児循環器学会雑誌 35 ( Suppl.1 ) s1 - 105 2019.6

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機能的単心室TCPC手術・術後のFontan routeに対して修正・介入を行った症例の検討

福嶋遥佑, 大月審一, 馬場健児, 近藤麻衣子, 栄徳隆裕, 今井祐喜, 重光祐輔, 平井健太, 原真祐子, 笠原真悟, 岩崎達雄

日本小児循環器学会雑誌 35 ( Suppl.1 ) s1 - 201 2019.6

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胎児期から当院で管理した抗SS-A抗体による先天性完全房室ブロック症例の臨床経過

近藤麻衣子, 馬場健児, 栄徳隆裕, 今井祐喜, 重光祐輔, 福嶋遥佑, 平井健太, 原真佑子, 大月審一, 笠原真悟, 岩崎達雄

日本小児循環器学会雑誌 35 ( Suppl.1 ) s1 - 198 2019.6

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有意なVSD、LVOTSのない修正大血管転位症のunnatural course

今井祐喜, 大月審一, 馬場健児, 近藤麻衣子, 栄徳隆裕, 重光祐輔, 福嶋遥佑, 平井健太, 原真祐子, 小林優

日本小児循環器学会雑誌 35 ( Suppl.1 ) s1 - 289 2019.6

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右室流出路再建術におけるContegraとYamagishi conduitの遠隔成績比較

平井健太, 馬場健児, 近藤麻衣子, 栄徳隆裕, 今井祐喜, 福嶋遥佑, 重光祐輔, 原真祐子, 小谷恭弘, 笠原真悟, 大月審一

日本小児循環器学会雑誌 35 ( Suppl.1 ) s1 - 225 2019.6

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左心低形成症候群の児に好発したPanayiotopoulos症候群様のてんかん

柴田敬, 秋山麻里, 福嶋遥佑, 松田奈央子, 水野むつみ, 諸岡輝子, 遠藤文香, 大月審一, 笠原真悟, 小林勝弘

てんかん研究 36 ( 2 ) 452 - 452 2018.9

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胎児エコーにて肺静脈血流が鬱血パターンを呈したhigh risk HLHS症例の検討

近藤麻衣子, 馬場健児, 栗田佳彦, 栄徳隆裕, 重光祐輔, 福嶋遥佑, 平井健太, 原真祐子, 大月審一, 笠原真悟, 岩崎達雄

日本小児循環器学会雑誌 34 ( Suppl.1 ) s1 - 244 2018.7

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新しいブタ拡張型心筋症モデルの開発と心臓内幹細胞治療の効果検証大型動物実験からヒト第1相臨床試験へ

平井健太, 大月審一, 馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 重光祐輔, 原真祐子, 後藤拓弥, 逢坂大樹, 王英正

日本小児循環器学会雑誌 34 ( Suppl.1 ) s1 - 142 2018.7

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主要体肺側副血行(MAPCA)の治療戦略におけるカテーテル診断の意義

福嶋遥佑, 大月審一, 馬場健児, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 重光祐輔, 平井健太, 川本祐也, 原祐子, 笠原真悟

日本小児循環器学会雑誌 34 ( Suppl.1 ) s1 - 141 2018.7

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無脾症候群単心室症例の治療成績に関する検討

重光祐輔, 原真祐子, 川本祐也, 平井健太, 福嶋遥佑, 栄徳隆裕, 栗田佳彦, 近藤麻衣子, 馬場健児, 大月審一, 笠原真悟

日本小児循環器学会雑誌 34 ( Suppl.1 ) s1 - 277 2018.7

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小児拡張型心筋症に対する自家心臓内幹細胞移植第一相試験

栄徳隆裕, 大月審一, 馬場健児, 近藤麻衣子, 福嶋遥佑, 重光祐輔, 平井健太, Hidemasa Ou

日本小児循環器学会雑誌 34 ( Suppl.1 ) s1 - 123 2018.7

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ステロイドパルス療法を施行し全快したサルモネラ脳症の1例

濱本諒, 所谷知穂, 西内律雄, 永野史翔, 浦田奈生子, 福嶋遥佑, 砂田哲, 金澤亜錦, 宮澤真理, 中田裕生, 吉川清志

日本小児科学会雑誌 122 ( 1 ) 81 - 81 2018.1

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狭小な心房間交通を有する左心低形成症候群に対するBalloon Atrial Septostomyの検討

福嶋遥佑, 馬場健児, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 重光祐輔, 平井健太, 塚原宏一, 岩崎達雄, 佐野俊二, 笠原真悟, 小谷恭弘, 大月審一

日本小児循環器学会雑誌 33 ( 6 ) 423 - 430 2017.11

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J02003&link_issn=&doc_id=20180418180002&doc_link_id=%2Fee7shoni%2F2017%2F003306%2F003%2F0423-0430%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fee7shoni%2F2017%2F003306%2F003%2F0423-0430%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
成人フォンタン手術後カテーテル治療

馬場健児, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 福嶋遥佑, 重光祐輔, 平井健太, 川本祐也, 小谷恭弘, 笠原真悟, 岩崎達雄, 大月審一

日本心臓病学会学術集会抄録 65回 ACHD - 4 2017.9

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循環破綻を来すほど巨大な心臓横紋筋腫に対し、救命のためeverolimusを使用し効果を得るも、ACTH療法を契機に再増大を認めた一例

重光祐輔, 馬場健児, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 福嶋遥佑, 平井健太, 大月審一, 吉本順子, 鷲尾洋介

日本小児循環器学会雑誌 33 ( Suppl.1 ) s1 - 297 2017.7

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Vector flow mapping(VFM)エコーを用いた心室内圧較差評価に関する検討

福嶋遥佑, 大月審一, 馬場健児, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 重光祐輔, 平井健太

日本小児循環器学会雑誌 33 ( Suppl.1 ) s1 - 180 2017.7

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循環破綻を来すほど巨大な心臓横紋筋腫に対し、救命のためeverolimusを使用した1例

重光祐輔, 馬場健児, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 福嶋遥佑, 平井健太, 吉本順子, 鷲尾洋介, 大月審一

日本小児循環器学会雑誌 32 ( 5 ) 439 - 444 2016.9

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J02003&link_issn=&doc_id=20161114310012&doc_link_id=%2Fee7shoni%2F2016%2F003205%2F013%2F0439-0444%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fee7shoni%2F2016%2F003205%2F013%2F0439-0444%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
機能的単心室における冠動脈バルーン閉鎖下心筋幹細胞注入の実際

栄徳隆裕, 馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 平井健太, 大月審一, 石上修大, 佐野俊二, 王英正

Journal of JPIC 1 ( 1 ) 13 - 19 2016.8

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Language：Japanese Publisher：(一社)日本先天性心疾患インターベンション学会

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肺動静脈瘻のリスクと治療介入に関する検討

重光祐輔, 平井健太, 福嶋遥佑, 栄徳隆裕, 栗田佳彦, 近藤麻衣子, 馬場健児, 大月審一, 岩崎達雄, 笠原真悟, 佐野俊二

日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 175 2016.7

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右室流出路再建術にContegraを使用した18症例の検討

平井健太, 馬場健児, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 福嶋遥佑, 重光祐輔, 大月審一, 笠原真悟, 佐野俊二, 塚原宏一

日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 216 2016.7

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長期予後を見据えたFontan児童・生徒の運動・学校・日常生活管理フォンタン術後の学童期の現状

福嶋遥佑, 大月審一, 馬場健児, 栗田佳彦, 近藤麻衣子, 栄徳隆裕, 重光祐輔, 平井健太, 佐野俊二, 笠原真悟, 新井禎彦

日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 130 2016.7

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小児インターベンション心臓病学の近年の進歩研究からカテーテルラボへ単心室血行動態を持つ小児に対する自己cardiosphere derived cellの冠動脈内注入療法(Intracoronary Infusion of Autologous Cardiosphere Derived Cells for Single Ventricle Physiology Children)

栄徳隆裕, 大月審一, 馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 重光祐輔, 平井健太, 王英正, 佐野俊二, 笠原真悟

日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 103 2016.7

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当院における左心低形成症候群の胎児診断からのリスク分類に基づいた治療計画

近藤麻衣子, 馬場健児, 栗田佳彦, 栄徳隆裕, 重光祐輔, 福嶋遥佑, 平井健太, 大月審一, 佐野俊二, 笠原真悟, 早田桂

日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 182 2016.7

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二心室治療可能であった左心系低形成症例について

栗田佳彦, 大月審一, 平井健太, 重光祐輔, 福嶋遥佑, 栄徳隆裕, 近藤麻衣子, 馬場健児, 塚原宏一, 佐野俊二, 岩崎達雄

日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 184 2016.7

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Norwood-Sano procedure RingedとNon-ringed RV-PA conduitの比較(Norwood-Sano Procedure:Ringed vs Non-Ringed RV-PA conduit)

栄徳隆裕, 馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 重光祐輔, 平井健太, 大月審一, 佐野俊二, 笠原真悟, 小谷恭弘

日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 185 2016.7

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治療に難渋した頻拍誘発性心筋症の一例

栗田佳彦, 大月審一, 平井健太, 重光裕介, 福嶋遥佑, 栄徳隆裕, 近藤麻衣子, 馬場健児, 塚原宏一, 佐野俊二, 伊藤浩

日本小児救急医学会雑誌 15 ( 2 ) 257 - 257 2016.6

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先天性心疾患に合併した自己免疫性好中球減少症周術期管理について

平井健太, 馬場健児, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 福嶋遥佑, 重光祐輔, 大月審一, 佐野俊二, 塚原宏一

日本小児科学会雑誌 120 ( 2 ) 366 - 366 2016.2

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Language：Japanese Publisher：(公社)日本小児科学会

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当施設におけるソタロールの使用経験

重光祐輔, 平井健太, 福嶋遥佑, 栄徳隆裕, 栗田佳彦, 近藤麻衣子, 馬場健児, 大月審一, 塚原宏一

日本小児循環器学会雑誌 31 ( Suppl.1 ) s1 - 302 2015.7

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急性または劇症型心筋炎が疑われ、当院入院となった9例の後方視的検討診断と予後について

平井健太, 重光祐輔, 福嶋遥佑, 栄徳隆裕, 栗田佳彦, 近藤麻衣子, 馬場健児, 大月審一, 笠原真悟, 佐野俊二, 塚原宏一

日本小児循環器学会雑誌 31 ( Suppl.1 ) s1 - 347 2015.7

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PA/IVSの治療戦略これからの小児科・外科のコラボレーション PA/IVSにおけるRV to Coronary Fistulaeは段階的RV DecompressionによりRegressする

栄徳隆裕, 大月審一, 馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 重光祐輔, 平井健太, 佐野俊二, 笠原真悟, 小谷恭弘

日本小児循環器学会雑誌 31 ( Suppl.1 ) s1 - 136 2015.7

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心外型総肺静脈還流異常症(ExtracardiacTAPVC)合併Asplenia症例の検討術後肺静脈狭窄に関与する因子について

近藤麻衣子, 大月審一, 馬場健児, 栗田佳彦, 栄徳隆裕, 重光祐輔, 福嶋遥佑, 平井健太, 塚原宏一, 佐野俊二, 笠原真悟

日本小児循環器学会雑誌 31 ( Suppl.1 ) s1 - 178 2015.7

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