Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector T Cell Differentiation while Sparing Regulatory T Cells

Takumi Kondo, Shuntaro Ikegawa, Takuya Fukumi, Yuichi Sumii, Hiroyuki Sugiura, Yasuhisa Sando, Makoto Nakamura, Yusuke Meguri, Miki Iwamoto, Yoshinobu Maeda, Ken-ichi Matsuoka

ImmunoHorizons   2021年6月

Pretransplant nivolumab further enhanced Treg expansion after posttransplant cyclophosphamide; another aspect for immune tolerance by PTCy after nivolumab

Shuntaro Ikegawa, Yusuke Meguri, Kentaro Mizuhara, Takuya Fukumi, Hiroki Kobayashi, Yuichi Sumii, Takumi Kondo, Yasuhisa Sando, Miki Iwamoto, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Keiko Fujii, Nobuharu Fujii, Yuka Fujisawa, Toshi Imai, Yoshinobu Maeda, Ken-ichi Matsuoka

Leukemia   2021年3月

5-aminolevulinic acid-mediated photodynamic therapy can target aggressive adult T cell leukemia/lymphoma resistant to conventional chemotherapy

Yasuhisa Sando, Ken-ichi Matsuoka, Yuichi Sumii, Takumi Kondo, Shuntaro Ikegawa, Hiroyuki Sugiura, Makoto Nakamura, Miki Iwamoto, Yusuke Meguri, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Keiko Fujii, Nobuharu Fujii, Atae Utsunomiya, Takashi Oka, Yoshinobu Maeda

Scientific Reports   10 ( 1 )   2020年10月

Post-transplantation cyclophosphamide restores early B-cell lymphogenesis that suppresses subsequent chronic graft-versus-host disease

Miki Iwamoto, Shuntaro Ikegawa, Takumi Kondo, Yusuke Meguri, Makoto Nakamura, Yasuhisa Sando, Hiroyuki Sugiura, Yuichi Sumii, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Keiko Fujii, Nobuharu Fujii, Misako Shibakura, Yoshinobu Maeda, Ken-ichi Matsuoka

Bone Marrow Transplantation   2020年10月

PTCy ameliorates GVHD by restoring regulatory and effector T-cell homeostasis in recipients with PD-1 blockade

Shuntaro Ikegawa, Yusuke Meguri, Takumi Kondo, Hiroyuki Sugiura, Yasuhisa Sando, Makoto Nakamura, Miki Iwamoto, Yoshinobu Maeda, Ken-ichi Matsuoka

Blood Advances   2019年12月

Plasma exchange eliminates residual mogamulizumab but does not warrant prompt recovery of peripheral Treg levels.

Sugiura H, Matsuoka KI, Sando Y, Meguri Y, Ikegawa S, Nakamura M, Iwamoto M, Yoshioka T, Asano T, Kondo E, Fujii K, Fujii N, Maeda Y

Transfusion and Apheresis Science   2019年7月

Macrophage elimination in bone marrow by dexamethasone palmitate is associated with successful engraftment in patients with hemophagocytic syndrome.

Sugiura H, Matsuoka KI, Matsuda M, Ikegawa S, Inomata T, Kuroi T, Asano T, Yoshida S, Nishimori H, Fujii K, Fujii N, Maeda Y

International journal of hematology   2019年5月

[Transfusion-associated circulatory overload with pulmonary alveolar hemorrhage following allogeneic bone marrow transplantation].

Adachi H, Doki N, Hino Y, Senoo Y, Ikegawa S, Watanabe D, Inamoto K, Yoshioka K, Najima Y, Kobayashi T, Kakihana K, Haraguchi K, Kitahara Y, Ohashi K

[Rinsho ketsueki] The Japanese journal of clinical hematology   2019年1月

Cytomegalovirus meningitis in a patient with relapsed acute myeloid leukemia.

Harada K, Sekiya N, Ikegawa S, Sasaki S, Kobayashi T, Ohashi K

International journal of hematology   2018年10月

Long-term outcomes in patients treated in the intensive care unit after hematopoietic stem cell transplantation.

Nakamura M, Fujii N, Shimizu K, Ikegawa S, Seike K, Inomata T, Sando Y, Fujii K, Nishimori H, Matsuoka KI, Morimatsu H, Maeda Y

International journal of hematology   2018年9月

Neurolymphomatosis in the Cauda Equina Diagnosed by an Open Biopsy.

Sasaki R, Ohta Y, Yamada Y, Tadokoro K, Takahashi Y, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Yasuhara T, Date I, Ikegawa S, Fujii N, Abe K

Internal medicine (Tokyo, Japan)   2018年8月

Progressive multifocal leukoencephalopathy after T‐cell replete HLA‐haploidentical transplantation with post‐transplantation cyclophosphamide graft‐versus‐host disease prophylaxis

Shuntaro Ikegawa, Nobuharu Fujii, Koh Tadokoro, Kota Sato, Miki Iwamoto, Masayuki Matsuda, Tomoko Inomata, Hiroyuki Sugiura, Takeru Asano, Shohei Yoshida, Hisakazu Nishimori, Ken‐ichi Matsuoka, Yoshinobu Maeda

Transplant Infectious Disease   2018年4月

Mild renal dysfunction defined by creatinine clearance rate has limited impact on clinical outcomes after allogeneic hematopoietic stem cell transplantation.

Ikegawa S, Matsuoka KI, Inomata T, Ikeda N, Sugiura H, Kuroi T, Asano T, Yoshida S, Nishimori H, Fujii N, Kondo E, Maeda Y, Tanimoto M

International journal of hematology   2018年1月

Erythrocytosis after allogeneic hematopoietic stem cell transplantation.

Hino Y, Doki N, Kurosawa S, Yamamoto K, Sakaguchi M, Harada K, Ikegawa S, Shingai N, Hattori K, Senoo Y, Igarashi A, Najima Y, Kobayashi T, Ohashi K

Clinical transplantation   2017年2月

Central Nervous System Involvement at the Time of Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with a Poor Outcome in Patients with Acute Myeloid Leukemia.

Ikegawa S, Doki N, Kaito S, Kurosawa S, Sakaguchi M, Harada K, Yamamoto K, Hino Y, Shingai N, Senoo Y, Watanabe D, Hagino T, Yoshioka K, Watakabe K, Ohashi K

Pathology oncology research : POR   2016年12月

Mycophenolate mofetil is effective only for involved skin in the treatment for steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

Hattori K, Doki N, Kurosawa S, Hino Y, Yamamoto K, Sakaguchi M, Harada K, Ikegawa S, Shingai N, Senoo Y, Igarashi A, Najima Y, Kobayashi T, Ohashi K

Annals of hematology   2016年10月

Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut.

Kakihana K, Fujioka Y, Suda W, Najima Y, Kuwata G, Sasajima S, Mimura I, Morita H, Sugiyama D, Nishikawa H, Hattori M, Hino Y, Ikegawa S, Yamamoto K, Ohashi K

Blood   2016年7月

Chronic myeloid leukemia relapsing ten years after allogenic bone marrow transplantation.

Hino Y, Doki N, Yamamoto K, Senoo Y, Sasajima S, Sakaguchi M, Hattori K, Kaito S, Kurosawa S, Harada K, Ikegawa S, Watanabe D, Hagino T, Yoshioka K, Ohashi K

[Rinsho ketsueki] The Japanese journal of clinical hematology   2016年5月

[Chronic myelogenous leukemia initially presenting with multiple subcutaneous tumors due to extramedullary hematopoiesis].

Kurosawa S, Doki N, Kaito S, Sakaguchi M, Harada K, Hino Y, Yamamoto K, Ikegawa S, Yosioka K, Watanabe D, Senoo Y, Watakabe K, Hagino T, Igarashi A, Ohashi K

[Rinsho ketsueki] The Japanese journal of clinical hematology   2016年4月

Clinical utility of high-flow nasal cannula oxygen therapy for acute respiratory failure in patients with hematological disease.

Harada K, Kurosawa S, Hino Y, Yamamoto K, Sakaguchi M, Ikegawa S, Hattori K, Igarashi A, Watakabe K, Senoo Y, Najima Y, Hagino T, Doki N, Ohashi K

SpringerPlus   2016年4月

Donor cell leukemia with bone marrow necrosis.

Ikegawa S, Najima Y, Sano N, Horiguchi SI, Kaito S, Kurosawa S, Sakaguchi M, Harada K, Hino Y, Yamamoto K, Senoo Y, Watanabe D, Yoshioka K, Ohashi K

[Rinsho ketsueki] The Japanese journal of clinical hematology   2016年1月

Allogeneic hematopoietic stem cell transplant overcomes poor prognosis of acute myeloid leukemia with myelodysplasia-related changes.

Ikegawa S, Doki N, Kurosawa S, Yamaguchi T, Sakaguchi M, Harada K, Yamamoto K, Hino Y, Shingai N, Senoo Y, Watanabe K, Igarashi A, Najima Y, Ohashi K

Leukemia & lymphoma   2016年1月

Retrospective analysis of clinical outcomes of the patients with chronic myeloid leukemia who stopped administration of tyrosine kinase inhibitors: a single institution experience.

Senoo Y, Yoshioka K, Kaito S, Kurosawa S, Harada K, Yamamoto K, Hino Y, Sakaguchi M, Ikegawa S, Watanabe D, Watakabe K, Hagino T, Igarashi A, Ohashi K

[Rinsho ketsueki] The Japanese journal of clinical hematology   2016年1月

CD25 expression on residual leukemic blasts at the time of allogeneic hematopoietic stem cell transplant predicts relapse in patients with acute myeloid leukemia without complete remission.

Ikegawa S, Doki N, Kurosawa S, Yamaguchi T, Sakaguchi M, Harada K, Yamamoto K, Hino Y, Shingai N, Senoo Y, Hattori K, Igarashi A, Najima Y, Ohashi K

Leukemia & lymphoma   2015年12月

Impact of prior azacitidine on the outcome of allogeneic hematopoietic transplantation for myelodysplastic syndrome.

Oshikawa G, Yoshioka K, Takahashi Y, Shingai N, Ikegawa S, Kobayashil T, Doki N, Kakihana K, Ohashi K, Sakamaki H

Pathology oncology research : POR   2015年4月

Clinical impact of CD25 expression on outcomes of allogeneic hematopoietic stem cell transplant for cytogenetically intermediate-risk acute myeloid leukemia.

Ikegawa S, Doki N, Yamamoto K, Shingai N, Takahashi Y, Aoki J, Yoshioka K, Narukawa K, Ishida S, Igarashi A, Oshikawa G, Kobayashi T, Kakihana K, Ohashi K

Leukemia & lymphoma   2014年11月

[Discussion meeting on the daily practice of leukemia].

Kizaki M, Nomura T, Ikegawa S, Takahashi N, Uchida N

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   2013年7月

Hepatocellular carcinoma in a case of Wilson's disease treated with radiofrequency ablation therapy.

Ikegawa S, Hiraoka A, Shimizu Y, Hidaka S, Tazuya N, Ichiryu M, Nakahara H, Tanabe A, Tanihira T, Hasebe A, Miyamoto Y, Ninomiya T, Hirooka M, Michitaka K

Internal medicine (Tokyo, Japan)   2011年7月

T-Charge™ Manufacturing of the Anti-BCMA CAR-T, Durcabtagene Autoleucel (PHE885), Promotes Expansion and Persistence of CAR-T Cells with High TCR Repertoire Diversity, 査読

142 ( Supplement 1 )   3469   2023年

Updated phase I study results of PHE885, a T-Charge manufactured BCMA-directed CAR-T cell therapy, for patients (pts) with r/r multiple myeloma (RRMM). 査読

Adam Samuel Sperling, Benjamin Avi Derman, Sarah Nikiforow, Soo-Yeon Im, Shuntaro Ikegawa, Rao H. Prabhala, Diego Hernandez Rodriguez, Yifang Li, David S. Quinn, David Pearson, Dexiu Bu, Jennifer Mataraza, Jessica Liegel, Anita D'Souza, Lawrence Rispoli, Marc Credi, Jerome Ritz, Andrzej J. Jakubowiak, Serena De Vita, Nikhil C. Munshi

Journal of Clinical Oncology   41 ( 16_suppl )   8004   2023年

Low Dose IL-2 Therapy in Patients with Chronic Gvhd Induces PD-1+treg That Are Highly Activated, Immune Suppressive, and Proapoptotic 査読

Shuntaro Ikegawa, MD, PhD., Takeru Asano MD, PhD., Haesook T. Kim PhD., Gordon J., Freeman PhD., Xia Bu PhD., Roger Belizaire MD, PhD., Jennifer Whangbo MD PHD, Rizwan Romee MD, Mahasweta Gooptu MD, Roman M Shapiro MD, Sarah Nikiforow, MD, PhD., Vincent T. Ho MD, Corey Cutler MD, MPH, Joseph H. Antin MD, Robert J. Soiffer MD, John Koreth MBBS, DPhil, Jerome Ritz MD

Transplantation and Cellular Therapy   28 ( Supplement )   S59 - S60   2022年