Faculty Profiles - ARIMURA Yuki

Papers - ARIMURA Yuki

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Clinical outcomes of gingivoperiosteoplasty for unilateral cleft lip and palate performed in early childhood. International journal

Tadashi Yamanishi, Yuki Arimura, Shoko Kirikoshi, Takayuki Hara, Takahiro Nishio, Tetsuya Seikai, Setsuko Uematsu, Juntaro Nishio

Journal of plastic, reconstructive & aesthetic surgery : JPRAS 97 268 - 274 2024.8

Language：English Publishing type：Research paper (scientific journal)

Conventional gingivoperiosteoplasty (GPP) performed during infancy adversely affects maxillary development. However, the outcomes of this procedure in early childhood have rarely been reported. Therefore, we examined the postoperative outcomes of GPP conducted in patients aged 1.5 years with unilateral cleft lip and palate (UCLP). This study included 87 non-syndromic patients with complete UCLP who had undergone early two-stage palatoplasty during the 1999-2004 period. The protocol comprised soft palate plasty at 1 year of age and hard palate closure at 1.5 years of age. In the GPP group (n = 34), we introduced the GPP procedure during hard palate closure; in the non-GPP group (n = 53), the labial side of the alveolar cleft remained intact. We examined computed tomography images taken at 8 years of age to observe bone formation at the alveolar cleft site. We also conducted cephalometric analysis to examine maxillary development at 12 years of age. Bone bridges at the alveolar cleft site were observed in 92% and 5.6% of the GPP and non-GPP groups, respectively. Moreover, 56% of the GPP group did not require secondary alveolar bone grafting (sABG), whereas all the patients in the non-GPP group underwent sABG. No statistically significant differences were noted in the maxillary anteroposterior length (GPP: 45.5 ± 3.7 mm, non-GPP: 45.9 ± 3.5 mm, p = 0.67) and sella-nasion-point A angle (GPP: 75.6 ± 4.5°, non-GPP: 73.8 ± 12.6°, p = 0.49). This study's findings suggest that GPP performed at 1.5 years of age minimises the necessity of sABG and does not exert a negative influence on maxillofacial development.

DOI： 10.1016/j.bjps.2024.07.067

PubMed

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当科における口唇口蓋裂症例に対する上顎骨骨延長術の応用

有村友紀, 天野克比古, 中辻和樹, 永田裕樹, 加藤壮真, 植田紘貴, 上岡寛, 飯田征二

日本顎変形症学会雑誌 34 ( 2 ) 136 - 136 2024.5

術前後にナゾメーターで鼻咽腔閉鎖機能を評価し上顎骨延長術により反対咬合の改善を行った口蓋裂症例の一例

植田紘貴, 岡直毅, 中西泰之, 有村友紀, 飯田征二, 上岡寛

日本顎変形症学会雑誌 34 ( 2 ) 137 - 137 2024.5

4切歯を含む上顎歯槽骨切り術によって歯列不正を改善した2症例

中辻和樹, 天野克比古, 谷本裕子, 河野加奈, 有村友紀, 永田裕樹, 加藤壮真, 上岡寛, 飯田征二

日本顎変形症学会雑誌 34 ( 2 ) 191 - 191 2024.5

A case of unilateral soft palate paralysis following minor head injury Reviewed

Arimura Yuki, Yamanishi Tadashi, Kurimoto Takayuki, Nishio Takahiro, Otsuki Koichi, Kirikoshi Shoko, Togawa Takeshi, Uematsu Setsuko

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 36 ( 6 ) 550 - 553 2023.11

唇顎口蓋裂患者に対する上顎骨前方部骨延長術と下顎骨後方移動術における硬軟組織変化の比較検討 Reviewed

安富成美, 植田紘貴, 有村友紀, 森谷徳文, 松村達志, 上岡寛, 飯田征二

中・四国矯正歯科学会雑誌 35 ( 1 ) 37 - 50 2023.8

骨性癒着が疑われた上顎中切歯を有する上顎前突症例に対する外科的矯正治療-4前歯での上顎前歯部歯槽骨切術- Reviewed

谷本裕子, 森谷徳文, 松村達志, 有村友紀, 近藤星, 飯田征二

中・四国矯正歯科学会雑誌 35 ( 1 ) 51 - 66 2023.8

下顎枝垂直骨切り術による下顎頭の2次元的な位置変化の解析およびその変化に関与する因子の検討

永田裕樹, 天野克比古, 森谷徳文, 有村友紀, 中辻和樹, 加藤壮真, 飯田征二

日本口腔科学会雑誌 72 ( 2 ) 77 - 77 2023.7

顎関節症状を伴う顔面非対称症例に対してLe Fort I型骨切り術とIVSROを施行した一治験例

田中敦子, 植田紘貴, 石田朋子, 中辻和樹, 有村友紀, 森谷徳文, 飯田征二, 上岡寛

日本顎変形症学会雑誌 33 ( 2 ) 208 - 208 2023.5

開口ゼロスプリントを用いて外科的矯正治療を行なった重度顔面非対称の1例

中辻和樹, 天野克比古, 永田倭代, 中村政裕, 有村友紀, 近藤星, 永田裕樹, 加藤壮真, 上岡寛, 飯田征二

日本顎変形症学会雑誌 33 ( 2 ) 219 - 219 2023.5

口腔支持療法により外来放射線治療を完遂できた口腔癌3症例

武田斉子, 有村友紀, 田村庄平, 中辻和樹, 三上彩可, 松崎秀信, 丸山貴之, 横井彩, 天野克比古, 水川展吉, 飯田征二

日本口腔ケア学会雑誌 17 ( 3 ) 242 - 242 2023.4

Mandibular condylar displacement and the associated factors following intraoral vertical ramus osteotomy

Yuki Nagata, Norifumi Moritani, Katsuhiko Amano, Yuki Arimura, Kazuki Nakatsuji, Soma Kato, Ayaka Mikami, Tatsushi Matsumura, Seiji Iida

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 35 ( 5 ) 390 - 396 2023.1

Comparing the Osteogenic Potential and Bone Regeneration Capacities of Dedifferentiated Fat Cells and Adipose-Derived Stem Cells In Vitro and In Vivo: Application of DFAT Cells Isolated by a Mesh Method. International journal

Kiyofumi Takabatake, Masakazu Matsubara, Eiki Yamachika, Yuki Fujita, Yuki Arimura, Kazuki Nakatsuji, Keisuke Nakano, Histoshi Nagatsuka, Seiji Iida

International journal of molecular sciences 22 ( 22 ) 2021.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: We investigated and compared the osteogenic potential and bone regeneration capacities of dedifferentiated fat cells (DFAT cells) and adipose-derived stem cells (ASCs). METHOD: We isolated DFAT cells and ASCs from GFP mice. DFAT cells were established by a new culture method using a mesh culture instead of a ceiling culture. The isolated DFAT cells and ASCs were incubated in osteogenic medium, then alizarin red staining, alkaline phosphatase (ALP) assays, and RT-PCR (for RUNX2, osteopontin, DLX5, osterix, and osteocalcin) were performed to evaluate the osteoblastic differentiation ability of both cell types in vitro. In vivo, the DFAT cells and ASCs were incubated in osteogenic medium for four weeks and seeded on collagen composite scaffolds, then implanted subcutaneously into the backs of mice. We then performed hematoxylin and eosin staining and immunostaining for GFP and osteocalcin. RESULTS: The alizarin red-stained areas in DFAT cells showed weak calcification ability at two weeks, but high calcification ability at three weeks, similar to ASCs. The ALP levels of ASCs increased earlier than in DFAT cells and showed a significant difference (p < 0.05) at 6 and 9 days. The ALP levels of DFATs were higher than those of ASCs after 12 days. The expression levels of osteoblast marker genes (osterix and osteocalcin) of DFAT cells and ASCs were higher after osteogenic differentiation culture. CONCLUSION: DFAT cells are easily isolated from a small amount of adipose tissue and are readily expanded with high purity; thus, DFAT cells are applicable to many tissue-engineering strategies and cell-based therapies.

DOI： 10.3390/ijms222212392

PubMed

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Attempt of thyX gene silencing and construction of a thyX deleted clone in a Mycobacterium bovis BCG. International journal

Yuki Arimura, Yusuke Minato, Takayuki Wada, Masaaki Nakayama, Ayako Ryumon, Nao Hirata, Chie Nakajima, Yasuhiko Suzuki, Manabu Ato, Kazuo Kobayashi, Naoko Ohara, Seiji Iida, Naoya Ohara

Microbiology and immunology 66 ( 1 ) 10 - 14 2021.9

Language：English Publishing type：Research paper (scientific journal)

Mycobacterium tuberculosis, the causative agent of tuberculosis, possess flavin-dependent thymidylate synthase, ThyX. Since thyX is absent in humans and was shown to be essential for M. tuberculosis normal growth, ThyX is thought to be an attractive novel TB drug target. This study assessed thyX essentiality in Mycobacterium bovis BCG strains using CRISPR interference based gene silencing and found that thyX is not essential in an M. bovis BCG Tokyo derivative strain. A thyX deletion mutant strain was successfully constructed from that strain, which reinforces the non-essentiality of thyX under a certain genetic background.

DOI： 10.1111/1348-0421.12944

PubMed

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A case of bilateral mandibular osteoma of atypical form

OTSUKI Koichi, YAMANISHI Tadashi, YAKUSHIJI Shota, ARIMURA Yuki, KONDO Takahide, UEMATSU Setsuko

Japanese Journal of Oral and Maxillofacial Surgery 66 ( 12 ) 616 - 621 2020.12

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

An osteoma is a benign osteogenic tumor arising from the proliferation of mature bone. They have been reported to occur primarily in the mandible in the oral and maxillofacial region. No previous report has described a large bilateral osteoma with wing-like form arising from the mandibular ramus. We report herein a case of bilateral osteoma of atypical form occurring in the mandible. A girl of 15 years of age presented with the chief complaint of swelling and food impaction in the left side of the oral floor. Computer tomography revealed a bone-like structure extending from the inside surface of the left side mandible to the ipsilateral oral floor. In addition, another bone-like mass was shown inside the right side mandibular ramus. Both structures presented wing-like characteristic forms. A clinical diagnosis of bilateral osteoma of the mandible was made, and we performed extirpation of the tumor from both sides under general anesthesia. Pathological findings showed that the left side mass was comprised of compacted bone alone and the right side mass contained both compacted bone and cancellous bone. In conjunction with imaging tests, the masses were both diagnosed as osteoma. In the 12 months following the surgery, there has been no recurrence in the left side, whereas a new bone formation was recognized in the right side surgical site.

DOI： 10.5794/jjoms.66.616

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Other Link： http://id.ndl.go.jp/bib/031227201

A case of t (11;22)(q23.3;q11.2) balanced translocation with unilateral complete cleft lip and palate

ARIMURA Yuki, YAMADA Chiaki, OKADA Ayumi, YAKUSHIJI Shota, OKAMOTO Narumi, IIDA Seiji

Japanese Journal of Oral and Maxillofacial Surgery 66 ( 8 ) 406 - 410 2020.8

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Chromosomal translocation is one of the most common types of chromosome abnormalities. Chromosomal translocation includes balanced and unbalanced translocation. However, it is difficult to detect balanced translocation because most balanced translocations have no excess or deficiency about genetic information and remain clinically asymptomatic; recently balanced translocation is related to infertility. Among balanced translocation of the 22nd and 11st, t (11;22) (q23.3;q11.2) balanced translocation is considered representative. Generally, in balanced translocation, it is thought that cases with abnormal phenotypes such as malformation are rare. t (11;22) (q23.3;q11.2) balanced translocation has not been reported to be a risk factor for cleft lip and palate. We report a case of t (11;22) (q23.3;q11.2) balanced translocation with unilateral complete cleft lip and palate.

DOI： 10.5794/jjoms.66.406

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Other Link： http://id.ndl.go.jp/bib/030625684

Differential diagnosis of ameloblastic fibro-odontoma: case report and literature review Reviewed

Takayuki Kurimoto, Tadashi Yamanishi, Takeshi Harada, Keiko Matsuoka, Setsuko Uematsu, Yuri Yamamoto, Yuki Arimura, Takeshi Togawa, Naoko Inoue, Juntaro Nishio

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 31 ( 1 ) 38 - 42 2019.1

Language：English Publisher：ELSEVIER SCIENCE INC

Ameloblastic fibro-odontoma (AFO) is an uncommon benign tumor of the jaws and mostly found in patients aged less than 20 years. In this report, we describe two cases of AFO in a 5-year-old girl and a 3-year-old boy. In both cases, radiographic images showed a well-defined unilocular radiolucency with partial radiopacity in their jaws. Lesions were removed under general anesthesia and histopathologically examined, which revealed then to be AFOs. Although unerupted teeth that came in contact with the lesions were left as is, no recurrence was observed postoperatively. A common aspect of both cases was that a presurgical pathological diagnosis, which is usually made on the basis of findings of presurgical biopsy under local anesthesia, was not possible because of their immaturity. Differential diagnoses of AFO include calcifying epithelial odontogenic tumor (CEOT), calcifying cystic odontogenic tumor (CCOT), adenomatoid odontogenic tumor (AOT), and complex odontoma (CO). As this includes tumors with a high risk of recurrence such as CEOT, an accurate clinical diagnosis is quite important. However, it was difficult to distinguish AFO from other tumors on the basis of clinical features including radiographic findings. Our review of literature revealed that there have been no reports of cases of CEOT and CCOT in patients aged less than 6 years, whereas AFO was frequently detected. We concluded that radiographic findings in combination with the patient's age were quite useful indicators for the differential diagnosis of AFO. Moreover, our case report supported the notion that impacted teeth adjacent to AFO can be preserved.

DOI： 10.1016/j.ajoms.2018.07.001

Web of Science

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病院歯科より Mulliken法を併用したMidface Rotation Advancementによる斜顔面裂形成術

山西整, 栗本聖之, 外川健史, 有村友紀, 西尾順太郎

大阪府歯科医師会雑誌 ( 749 ) 16 - 17 2017.3

Language：Japanese Publisher：(一社)大阪府歯科医師会

患児は出生直後から口蓋裂を伴う両側斜顔面裂、両側下眼瞼欠損、右眼球突出、右前腕欠損を認め、羊膜索症候群と診断した。生後5ヵ月で斜顔面裂形成術を施行した。右側眼球は生後2日で摘出した。両側の下眼瞼の欠損、顔面の右側には上口唇赤唇から右側内眼角に至る完全裂、左側は右側と同様の位置に不完全の斜顔面裂を認めた。裂形成は、両側のMidface rotation advancement、鼻唇皮弁による下眼瞼の再建およびMulliken法を応用した口唇形成術を組み合わせた。術後の縫合線は大部分が外鼻の輪郭に沿うため、あまり目立たない創となり、Mulliken法を応用した口唇部では良好なキューピッド弓が形成された。

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Intramuscular venous malformation with multiple phleboliths in the masseter muscle

FUJITA Yuki, MIZUTANI Masahide, ARIMURA Yuki, IKEDA Atsushi, YANAGI Yoshinobu, IIDA Seiji

Japanese Journal of Oral and Maxillofacial Surgery 63 ( 11 ) 593 - 597 2017

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

This report describes a case of venous malformation associated with multiple phleboliths in the masseter muscle. A 21-year-old woman presented with swelling of the left cheek. Computed tomography and magnetic resonance imaging suggested the presence of phleboliths in the venous malformation in the left masseter muscle. The venous malformation with the phleboliths was extirpated through an intraoral approach with the patient under general anesthesia. The postoperative course was uneventful, and the patient was asymptomatic with no signs of recurrence during 3 years of follow-up.

DOI： 10.5794/jjoms.63.593

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Other Link： http://id.ndl.go.jp/bib/028671058

BCG thyX変異株の作製とその性状解析

有村友紀

十全総合病院雑誌 22 ( 1 ) 35 - 35 2016.12

BCG thyX変異株の作製とその解析

有村友紀

岡山歯学会雑誌 35 ( 1 ) 1 - 10 2016.6

Language：Japanese Publisher：岡山歯学会

BCGのチミジル酸合成酵素遺伝子(thyA)欠損株ΔthyAとthyX欠損株ΔthyXを2段階相同組換え法により作製した。ΔthyAとΔthyXにおいてそれぞれthyAとthyXの発現がないことをRT-PCR法により確認した。ΔthyAと同様にΔthyXもソートン培地表面で増殖し、チミジル酸およびチミンに対して栄養要求性を示さなかった。PAS添加寒天培地においてBCG Tokyo株、ΔthyA、ΔthyX、過剰発現株thyA+とthyX+を培養した結果、ΔthyAとthyX+のみPAS耐性を有し、ΔthyXはPAS感受性のままであった。定量RT-PCRではthyX+におけるthyAとの発現量はBCG Tokyo株に対して低下し、thyXの発現量はΔthyAとthyX+のいずれにおいてもBCG Tokyo株に対して有意に上昇していた。BCGではthyAとthyXは必須遺伝子ではなく、thyXの過剰発現はPAS耐性を付与した。

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頸部郭清術後に生じた両側乳糜胸の1例

池田篤司, 水谷雅英, 山本祐也, 有村友紀, 植村亜由美, 飯田征二

日本口腔外科学会雑誌 61 ( 5 ) 288 - 292 2015.5

Language：Japanese Publisher：(公社)日本口腔外科学会

40歳男。左側舌縁部に長径10mmで周囲に硬結を伴う潰瘍が認められた。CT、MRI、PET-CTより、左側舌癌(cT1N0M0,stage I)が疑われ、生検より扁平上皮癌と診断された。左側舌部分切除を行ったが、術後約9ヵ月に左側顎下に頸部リンパ節後発転移が認められたため、左側肩甲舌骨筋上顎部郭清術を行った。病理組織診断でLevel IbとLevel IIにリンパ節転移が認められたため、左側根治的頸部郭清術を行った。また、胸管損傷を視認したため、同部を結紮し持続吸引ドレーンを顎下部と鎖骨上窩に留置した。経口摂取開始後、鎖骨上窩のドレーンより乳白色の液体の排出があり、乳糜漏と診断した。漏出は手術時に結紮した胸管の末梢部からで、周囲組織を含めて再結紮した。術4日目に呼吸困難が出現し、単純X線、CTで両側肺野に胸水貯留を認めたため、胸腔穿刺を行った。穿刺液はトリグリセライド高値であり両側乳糜胸と診断した。胸腔穿刺後、呼吸困難、乳糜胸水は改善し、以後、再貯留を認めない。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J01073&link_issn=&doc_id=20150608460005&doc_link_id=10.5794%2Fjjoms.61.288&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.61.288&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

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Papers - ARIMURA Yuki