Updated on 2023/01/08

写真a

 
MATSUZAKI Kumiko
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
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Degree

  • 学士(歯学) ( 岡山大学 )

  • 博士(歯学) ( 岡山大学 )

Research Interests

  • Operative Dentistry

  • 歯科保存修復

Research Areas

  • Life Science / Conservative dentistry

Education

  • Okayama University    

    - 2009

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  • Okayama University   医歯薬学総合研究科   生体機能再生・再建学講座 歯科保存修復学分野

    - 2009

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    Country: Japan

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  • Okayama University    

    - 2005

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  • Okayama University   歯学部  

    - 2005

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    Country: Japan

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Research History

  • - Assistant Professor,University Hospital of Medicine and Dentistry,Okayama University

    2009

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  • - 岡山大学岡山大学病院 助教

    2009

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Professional Memberships

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Papers

  • Effects of BMP-2 on bone response using gelatin hydrogel in estrogen-deficient rats. Reviewed

    Yamaji K, Yokoyama A, Matsuzaki K, Sugaya T, Shimada Y, Ohara N, Yoshiyama M

    J Oral Tissue Engin   20 ( 2 )   2022.12

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  • PCA配合歯磨剤のレジン象牙質接着性への影響の検討 Reviewed

    吉山昌宏, 大原直子, 松崎久美子

    象牙質歯髄治療学会雑誌   2 ( 1 )   8 - 10   2022.2

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    Authorship:Last author   Language:Japanese   Publishing type:Research paper (scientific journal)  

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  • Effect of gelatin hydrogel containing BMP-2 on bone formation in aged rats Reviewed

    Yamaji Kozo, Yokoyama Akihito, Matsuzaki Kumoko, Ohara Naoko, Sugaya Tsutomu, Yoshiyama Masahiro

    J Oral Tissue Engin.   19 ( 1 )   10 - 14   2021.9

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  • 漂白歯面変化のSS-OCT評価

    神農 泰生, 島田 康史, 松崎 久美子, 横山 章人, Sadr Alireza, 角 保徳, 田上 順次, 吉山 昌宏

    日本歯科保存学雑誌   64 ( 4 )   265 - 270   2021.8

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    Language:Japanese   Publisher:(NPO)日本歯科保存学会  

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  • 早期頬粘膜癌に対する高線量率RALSによる腔内照射(モールド法)の1例

    松崎 秀信, 勝井 邦彰, 武田 斉子, 松崎 久美子, 吉山 昌宏, 浅海 淳一

    頭頸部癌   47 ( 2 )   247 - 247   2021.5

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    Language:Japanese   Publisher:(一社)日本頭頸部癌学会  

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  • Assessment of Demineralization Inhibition Effects of Dentin Desensitizers Using Swept-Source Optical Coherence Tomography. International journal

    Kumiko Matsuzaki, Yasushi Shimada, Yasuo Shinno, Serina Ono, Kozo Yamaji, Naoko Ohara, Alireza Sadr, Yasunori Sumi, Junji Tagami, Masahiro Yoshiyama

    Materials (Basel, Switzerland)   14 ( 8 )   1876 - 1876   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    The purpose of this study was to evaluate the mechanism of action and the inhibiting effects of two types of desensitizers against dentin demineralization using pre-demineralized hypersensitivity tooth model in vitro. In this study, we confirmed that a hypersensitivity tooth model from our preliminary experiment could be prepared by immersing dentin discs in an acetic acid-based solution with pH 5.0 for three days. Dentin discs with three days of demineralization were prepared and applied by one of the desensitizers containing calcium fluoro-alumino-silicate glass (Nanoseal, NS) or fluoro-zinc-silicate glass (Caredyne Shield, CS), followed by an additional three days of demineralization. Dentin discs for three days of demineralization (de3) and six days of demineralization (de6) without the desensitizers were also prepared. The dentin discs after the experimental protocol were scanned using swept-source optical coherence tomography (SS-OCT) to image the cross-sectional (2D) view of the samples and evaluate the SS-OCT signal. The signal intensity profiles of SS-OCT from the region of interest of 300, 500, and 700 µm in depth were obtained to calculate the integrated signal intensity and signal attenuation coefficient. The morphological differences and remaining chemical elements of the dentin discs were also analyzed using scanning electron microscopy and energy-dispersive X-ray spectroscopy. SS-OCT images of CS and NS groups showed no obvious differences between the groups. However, SS-OCT signal profiles for both the CS and NS groups showed smaller attenuation coefficients and larger integrated signal intensities than those of the de6 group. Reactional deposits of the desensitizers even after the additional three days of demineralization were observed on the dentin surface in NS group, whereas remnants containing Zn were detected within the dentinal tubules in CS group. Consequently, both CS and NS groups showed inhibition effects against the additional three days of demineralization in this study. Our findings demonstrate that SS-OCT signal analysis can be used to monitor the dentin demineralization and inhibition effects of desensitizers against dentin demineralization in vitro.

    DOI: 10.3390/ma14081876

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  • 岡山大学病院における放射線治療支援への取り組み

    宮崎 文伸, 松崎 秀信, 松崎 久美子, 青山 英樹, 宇野 弘文, 竹内 哲男, 上田 明広, 太田 圭二, 浅海 淳一, 窪木 拓男

    日本口腔顎顔面技工学会会誌   20 ( 1 )   44 - 44   2021.4

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    Language:Japanese   Publisher:日本口腔顎顔面技工学会  

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  • 岡山大学病院頭頸部がんセンターにおけるエピシル使用経験について

    武田 斉子, 水川 展吉, 田村 庄平, 岡田 亜由美, 中田 靖章, 横井 彩, 丸山 貴之, 松崎 秀信, 松崎 久美子, 藤代 万由, 佐々木 禎子, 山中 玲子, 安藤 瑞生, 木股 敬裕, 浅海 淳一, 飯田 征二

    日本口腔ケア学会雑誌   15 ( 3 )   172 - 172   2021.4

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    Language:Japanese   Publisher:(一社)日本口腔ケア学会  

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  • 乾燥が成形修復材料の質量および曲げ強度に及ぼす影響(共著) Reviewed

    澁谷和彦, 大原直子, 入江正郎, 小野瀬里奈, 松崎久美子, 松本卓也, 吉山昌宏

    日本歯科保存学雑誌   63 ( 2 )   199 - 206   2020.4

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  • Evaluation of weight loss during intensity-modulated radiation therapy for head and neck cancer patients Invited Reviewed

    Matsuzaki Hidenobu, Yoshiyama Masahiro, Asaumi Jun-ichi, Kimata Yoshihiro, Katsui Kuniaki, Matsuzaki Kumiko, Nagamoto Yukiko, Takahara Yoko, Kubo Kazuko, Kajikiyo Tomomi, Mizukawa Nobuyoshi, Kariya Shin

    Toukeibu Gan   46 ( 3 )   264 - 269   2020

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japan Society for Head and Neck Cancer  

    The purpose of this study was to investigate the predictive factors of weight loss in head and neck cancer patients treated by intensity-modulated radiation therapy (IMRT). We retrospectively reviewed 43 patients with head and neck cancers treated with radical RT at doses ≥ 60Gy from January 2016 to December 2018. All patients received chemo-IMRT. The median weight loss was 8.5%. The incidence of weight loss ≥ 5% was 88% (38 patients) and ≥ 10% was 35% (15 patients). The factors significantly associated with ≥ 10% weight loss in the univariate analysis were younger age (p=0.009), size of planning target volume for gross tumor volume (<0.001), size of total planning target volume including prophylactic nodal areas (p=0.021), presence of lymph node metastasis (p=0.04), higher maximum radiation dose in the oral cavity (p=0.02), and dental status (maxillary and/or mandibular edentulous, p=0.008). Sex, body mass index, tumor site, T stage, diabetes mellitus, percutaneous endoscopic gastrostomy, and mean dose of radiation in the oral cavity were not significantly associated with weight loss. In multivariate analysis of ≥ 10% weight loss, younger age (p=0.03) and dental status (dentulous patient, p=0.013) were significantly associated with weight loss. From these results, younger age and dental status (dentulous patient) might be predictors of ≥ 10% weight loss during IMRT for head and neck cancer.

    DOI: 10.5981/jjhnc.46.264

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  • Color Matching Evaluation Using the Visual Analog Scale Reviewed

    Serina ONO, Masahiro YOSHIYAMA, Naoko OHARA, Kumiko MATSUZAKI, Kazuhiko SHIBUYA, Akihito YOKOYAMA, Kei TAKAHASHI, Yasuo SHINNO, Kozo YAMAJI, Yasushi SHIMADA

    The Japanese Journal of Conservative Dentistry   63 ( 1 )   30 - 37   2020

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Conservative Dentistry  

    <p> Purpose: Recently, the application of composite resin restorations has expanded. Although chromatic studies of composite resins have progressed, color differences measured by colorimeters and visual color evaluation do not always match. The aim of this study was to establish a method of evaluating the visual color of composite resins by using the visual analog scale (VAS), which evaluates subjective data as a continuous variable, and to examine its validity.</p><p> Method: One structural color composite resin (experimental resin : ECM-001) and three commercial composite resins of shade A3 were used in this study. Class Ⅴ and class Ⅲ cavities were prepared in artificial maxillary central incisors of four shades (A1, A2, A3, and A3.5) and each composite resin was filled and its color matching was evaluated on a black-and-white background using VAS. The correlation between VAS value and visual evaluation was analyzed. The color matching of teeth and composite resin were statistically analyzed using one-way analysis of variance and Tukey's HSD test (p<0.05). Background differences in the same sample were analyzed by the t-test (p<0.05).</p><p> Results: In the Class Ⅴ restoration, ECM-001 showed better color matching than other composite resins. In the Class Ⅲ restoration, ECM-001 showed excellent color matching with a wide range of teeth shades on the white background. The VAS values of the other composite resins were higher on the black background than on the white background. However, the VAS value of ECM-001 on the black background tended to decrease. Because the evaluation of VAS color matching by evaluators showed the same tendency, the VAS value reflects information that can be recognized by visual observation. It is suggested that the evaluation of VAS value correlates with visual evaluation.</p><p> Conclusion: It is suggested that the evaluation of color matching of composite resin restorations using VAS is useful for structural color composite resins, providing a new method of visually evaluating composite resin restorations.</p>

    DOI: 10.11471/shikahozon.63.30

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  • Effects of Direct Pulp Capping on Hard Tissue Formation by Using Alginate Gel Containing Bone Morphogenetic Protein-2.Effects of Direct Pulp Capping on Hard Tissue Formation by Using Alginate Gel Containing Bone Morphogenetic Protein-2.(jointly worked) Reviewed

    Yokoyama Akihito, Yamaji Kozo, Ohara Naoko, Matsuzaki Kumiko, Shimada Yasushi, Yoshiyama Masahiro

    Journal of Oral Tissue Engineering   17 ( 2 )   53 - 58   2019.12

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    DOI: 10.11223/jarde.17.53

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  • Influence of 10-MDP concentration on the adhesion and physical properties of self-adhesive resin cements. Reviewed International journal

    Kazuhiko Shibuya, Naoko Ohara, Serina Ono, Kumiko Matsuzaki, Masahiro Yoshiyama

    Restorative dentistry & endodontics   44 ( 4 )   e45 - 10   2019.11

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    Objectives: Self-adhesive resin cements contain functional monomers that enable them to adhere to the tooth structure without a separate adhesive or etchant. One of the most stable functional monomers used for chemical bonding to calcium in hydroxyapatite is 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP). The aim of this study was to evaluate the influence of the10-MDP concentration on the bond strength and physical properties of self-adhesive resin cements. Materials and Methods: We used experimental resin cements containing 3 different concentrations of 10-MDP: 3.3 wt% (RC1), 6.6 wt% (RC2), or 9.9 wt% (RC3). The micro-tensile bond strength of each resin cement to dentin and a hybrid resin block (Estenia C&B, Kuraray Noritake Dental) was measured, and the fractured surface morphology was analyzed. Further, the flexural strength of the resin cements was measured using the three-point bending test. The water sorption and solubility of the cements following 30 days of immersion in water were measured. Results: The bond strength of RC2 was significantly higher than that of RC1. There was no significant difference between the bond strength of RC2 and that of RC3. The water sorption of RC3 was higher than that of any other cement. There were no significant differences in the three-point bending strength or water solubility among all three types of cements. Conclusions: Within the limitations of this study, it is suggested that 6.6 wt% 10-MDP showed superior properties than 3.3 wt% or 9.9 wt% 10-MDP in self-adhesive resin cement.

    DOI: 10.5395/rde.2019.44.e45

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  • 岡山大学病院における放射線治療支援への取り組み

    宮崎 文伸, 松崎 秀信, 松崎 久美子, 青山 英樹, 宇野 弘文, 竹内 哲男, 上田 明広, 太田 圭二, 浅海 淳一, 窪木 拓男

    日本口腔顎顔面技工学会学術大会プログラム・抄録集   21回   29 - 29   2019.11

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    Language:Japanese   Publisher:日本口腔顎顔面技工学会  

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  • 透明根管模型歯における根管充填の評価法に関する検討 Reviewed

    松崎 久美子, 大原 直子, 澁谷 和彦, 横山 章人, 岡田 俊輔, 村上 純, 久富 美紀, 浅海 淳一, 吉山 昌宏

    岡山歯学会雑誌   38 ( 1 )   11 - 18   2019.6

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:岡山歯学会  

    歯学部学生の臨床前基礎実習において透明根管模型歯は、全ての学生が同一条件下で実習を行えることや、根管治療における各ステップを目視できる等の利点がある。今回、本学歯学部4年次生47名が象牙質歯髄複合体診断・治療学実習の実技試験で根管充填を行った透明根管模型歯について、視診による評価と、デジタルX線画像のモニタ上での視診による評価、およびデジタルX線画像を画像解析ソフト(ImageJ)により解析した評価を行い、各評価法の妥当性について比較検討した。その結果、画像解析ソフトで解析する方法は成績の過小評価を防ぐうえで有用であり、より客観的な評価が可能と考えられた。

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  • Effects of Transforming Growth Factor-β1 and Bone Morphogenetic Protein-2 on Bone Formation using a Bioabsorbable Scaffold at Palatal Sites in Rats.(jointly worked)

    Yamaji Kozo, Yokoyama Akihito, Shimada Yasushi, Sugaya Tsutomu, Ohara Naoko, Matsuzaki Kumiko, Yoshiyama Masahiro

    J Oral Tissue Eng   16 ( 2 )   74 - 79   2018.12

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  • 放射線性下顎骨壊死に関する検討

    松崎秀信, 勝井邦彰, 松崎久美子, 木股敬裕

    頭頸部癌   44 ( 1 )   57 - 61   2018

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  • Effects of Remineralization-accelerating Agent in Odontoblast-like Cell (MDPC-23)

    Yasuo Sinno, Kumiko Matsuzaki, Yasushi Shimada, Masahiro Yoshiyama

    Journal of Oral Tissue Engineering   15 ( 3 )   165 - 170   2018

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    DOI: 10.11223/jarde.15.165

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  • The role of dentistry other than oral care in patients undergoing radiotherapy for head and neck cancer

    Hidenobu Matsuzaki, Kumiko Tanaka-Matsuzaki, Fuminobu Miyazaki, Hideki Aoyama, Hiroki Ihara, Norihisa Katayama, Kuniaki Katsui, Kengo Himei, Tetsuo Takeuchi, Tomoo Onoda, Yoshihiro Kimata, Jun-ichi Asaumi

    Japanese Dental Science Review   53 ( 2 )   46 - 52   2017.5

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    Language:English   Publisher:Elsevier Ltd  

    The usefulness of dental approaches, such as oral management, has gained recognition among patients treated for head and neck cancer. In particular, oral management plays a very important role before, during, and after treatment in patients undergoing radiotherapy, chemotherapy, or a combination of both. However, specialized dentistry knowledge and techniques that are useful for patients undergoing radiotherapy for head and neck cancer have yet to be reported. Therefore, in this review article, our aim is to introduce dental approaches in radiotherapy for patients with head and neck cancer that have been developed and are currently being used at our institute.

    DOI: 10.1016/j.jdsr.2016.09.003

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  • Influence of Dentin Desensitizer on Bond Strength of Self-etching Adhesive System

    Kumiko MATSUZAKI-TANAKA, Naoko OHARA, Kazuhiko SHIBUYA, Serina ONO, Akihito YOKOYAMA, Kozo YAMAJI, Masahiro YOSHIYAMA

    The Japanese Journal of Conservative Dentistry   60 ( 1 )   22 - 31   2017

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    Language:Japanese   Publisher:The Japanese Society of Conservative Dentistry  

    <p> Purpose: Clinically, resin composite repair for dentin hypersensitivity with substantial defects such as wedge-shaped defects is commonly performed a few days after applying the densensitizer to dentin. In this study, we investigated the influence of pre-treatment of dentin densensitizers on bond strength.</p><p> Materials and Methods: We applied three desensitizers (MS coat ONE, F Varnish, and Nanoseal) on an artificial model of hypersensitive dentin using human premolars, and observed the surface structure by scanning electron microscope (SEM). Then, the specimens to which the three desensitizers had been applied were treated with Clearfil Mega Bond FA. We morphologically observed by SEM the surface of dentin which had been treated with the primer. Furthermore, the micro-tensile bond strength (μTBS) for the specimens which were incrementally built up by resin composites was measured in a universal testing machine. The interface between resin and dentin of specimens was observed by SEM and confocal laser scanning microscope (CLSM).</p><p> Results: The surfaces of specimens to which each desensitizer had been applied showed morphological characters having the effects of suppressing hypersensitivity. Regarding μTBS, there were no significant differences among all groups. In the group of MS coat ONE, MS coat ONE was not completely removed by the application of Mega Bond FA primer. Although the penetrations of the primer into dentin tubules were small, the thickness of the bond layer was greater. The specimens of F Varnish showed the functions of self-etching adhesive systems, because the varnishes had been partially removed by Mega Bond FA primer. In the group of Nanoseal, Mega Bond FA primer was almost removed by Nanoseal, and penetrated deeply into the dentinal tubules.</p><p> Conclusion: The three desensitizers used in this study had no effect on the bond strength of self-etching adhesive systems to the artificial model of hypersensitive dentin.</p>

    DOI: 10.11471/shikahozon.60.22

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  • Effects of Aging on Bone Formation Induced by BMP-2 using Low-intensity Pulsed Ultrasound

    YAMAJI Kozo, YOKOYAMA Akihito, MATSUZAKI Kumiko, OHARA Naoko, NISHIYAMA Eriko, SUGAYA Tsutomu, YOSHIYAMA Masahiro

    Journal of Oral Tissue Engineering   14 ( 1 )   65 - 69   2016

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    Language:English   Publisher:Japanese Association of Regenerative Dentistry  

    <p>The purpose of this study was to evaluate the effects of aging on bone formation induced by Bone Morphogenetic Protein-2 (BMP-2) using low-intensity pulsed ultrasound (LIPUS)in 12-week-old (12w group) and 70-week-old (70w group) Wistar rats.</p><p>The experimental sites (palatal subperiosteal sites) were divided into three sites as follows: BMP site, BMP-2 was implanted; LI-BMP site, LIPUS treatment was performed every three days after implantation of BMP-2; and Control site, neither implantation of BMP-2 nor LIPUS treatment was done.</p><p>At 3 weeks after surgery, thickness of new bone (TNB) was significantly higher in both the BMP and LI-BMP sites than in the Control site (P<0.05). TNB of every site in the 12w group was significantly higher than that of the same experimental site in the 70w group (P<0.05). Newly formed bone was almost integrated with original bone at the LI-BMP site.</p><p>These results suggest that LIPUS enhances the maturation of bone formation induced by BMP-2 even in senescent rats, although the volume of bone decreased with aging.</p>

    DOI: 10.11223/jarde.14.65

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  • Study of Pluripotency and Activation of Totipotency in Human Adipose-derived Stem Cells

    IZAWA Shunji, YAMAJI Kozo, YOKOYAMA Akihito, MATSUZAKI Kumiko, OHARA Naoko, YOSHIYAMA Masahiro

    Journal of Oral Tissue Engineering   13 ( 3 )   131 - 135   2016

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    Language:English   Publisher:Japanese Association of Regenerative Dentistry  

    Tissue regeneration is the important issue in the field of operative dentistry. In the previous study, we demonstrated that TNFα activates the potential for totipotency in human bone marrow mesenchymal stem cells (hMSCs) and leads to the regeneration of target cells or tissues along with the appropriate differentiating factor such as Emd-Gel. In this study, we apply the transcription factor set of TNF-α and Amelogenin to the human adipose-derived stem cells (hASCs) and our results indicate that this transcription factor set differentiate hASCs into odontblasts simillary and suggest that TNFα activates potential totipotency of hASCs and the activation can lead to the regeneration of target cells or tissues

    DOI: 10.11223/jarde.13.131

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  • 頭頸部がんに対する放射線治療において歯科技工士の果たす役割

    宮崎 文伸, 松崎 秀信, 青山 英樹, 田中 久美子, 宇野 弘文, 水川 展吉, 竹内 哲男, 勝井 邦彰, 小野田 友男, 浅海 淳一, 木股 敬裕, 窪木 拓男

    岡山歯学会雑誌   34 ( 2 )   77 - 78   2015.12

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  • Influence of Incorporating Sodium Fluoride on Flexural Strength, Water Absorption and Solubility of Adhesive Resin Cements

    Naoko OHARA, Kazuhiko SHIBUYA, Kumiko TANAKA, Tomohiro HOSHIKA, Azusa ENDO, Maiko NISHIMURA, Akiko TAKEUCHI, Kozo YAMAJI, Yoshihiro NISHITANI, Masahiro YOSHIYAMA

    Jpn J Conserv Dent   58 ( 1 )   10 - 16   2015

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    Language:Japanese   Publisher:The Japanese Society of Conservative Dentistry  

    Purpose: By incorporating sodium fluoride in adhesive resin cement, the release of fluoride from the cement is expected to strengthen the teeth and prevent secondary caries. However, there is a concern that such fluoride incorporation and release could impair the physical properties of the cement. In this study, we investigated the influence of incorporating sodium fluoride on the flexural strength, water absorption and solubility of adhesive resin cement.<br> Materials and Methods: The experimental resin cements were prepared at concentrations of 0-20 wt% sodium fluoride. The amounts of fluoride released from the cements were measured from day 1 to day 84. Next, a three-point bending test of the experimental resin cements was performed after initial curing (24 hours storage in water at 37°C) and after thermal cycle loading (5°C-55°C, 10,000 times). Furthermore, water absorption and solubility following 30 days immersion in water were measured.<br> Results: Fluoride release increased with an increase in the content rate of sodium fluoride. After initial curing, the three-point bending strengths of 5 wt% and 10 wt% sodium fluoride compounded cement were not statistically decreased compared to those of sodium fluoride 0 wt%, but were significantly reduced by incorporation of more than 15 wt%. There were no significant differences in the strength between 15 wt% sodium fluoride compounded cement and 20 wt% sodium fluoride compounded cement. Similar results were also observed in the comparison of flexural strength after thermal cycle loading. Regarding the 30-day water absorption amount, there was no significant difference between 5 wt% sodium fluoride compounded cement and that of 0 wt% sodium fluoride cement. However, the 30-day water absorption of 10 wt% sodium fluoride compounded cement was significantly increased compared to that of 0 wt% sodium fluoride compounded cement. The solubility was not significantly different between the content rate of 0-10 wt% sodium fluoride.<br> Conclusion: Increasing the sodium fluoride content improved the amount of fluoride release. On the other hand, the flexural strength of the cement was decreased, and the amounts of water absorption and solubility were increased. Within the limit of this study, it is suggested that 10 wt% sodium fluoride compounded cement could provide fluoride release without decreasing mechanical strength.

    DOI: 10.11471/shikahozon.58.10

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    Other Link: http://search.jamas.or.jp/link/ui/2015218122

  • Tooth Wearに対してコンポジットレジンによる審美修復を行った症例(共著)

    田中久美子, 徳善英紀, 大原直子, 星加知宏, 高橋圭, 神農泰生, 伊澤俊次, 山路公造, 西谷佳浩, 吉山昌宏

    岡山歯学会雑誌   33 ( 1 )   1 - 6   2014

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  • 垂直歯根破折歯を口腔外接着再植法にて保存した症例(共著)

    大原直子, 田中久美子, 垣内伸子, 星加知宏, 高橋圭, 神農泰生, 伊澤俊次, 山路公造, 西谷佳浩, 吉山昌宏

    岡山歯学会雑誌   33 ( 1 )   7 - 10   2014

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  • Observation of the Resin-dentin Interfacial Ultrastructure Using Confocal Laser Scanning Microscope with Fluorescent Dye

    TANAKA Kumiko, NISHITANI Yoshihiro, OHARA Naoko, SHIBUYA Kazuhiko, YOSHIYAMA Masahiro

    The Japanese Journal of Conservative Dentistry   56 ( 4 )   310 - 317   2013

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    Purpose: The purpose of this study was to evaluate penetration of self-etching primer to human sound dentin using confocal laser scanning microscope (CLSM) with fluorescent dye. Methods: The fluorescent dye Rhodamine B was mixed into self-etching primer of Clearfil Mega Bond FA (Kuraray Noritake Dental) at the concentration of 0, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1%, or 0.2%. All dentin surfaces were treated with Clearfil Mega Bond FA. Resin composites (Clearfil AP-X) were built up incrementally according to the manufacturer's instruction. 64 specimens were subjected to the observation of the interface of resin and dentin with CLSM and SEM. The 32 specimens were then serially sectioned into multiple sliced parts and then micro-tensile bond strength (MTBS) was measured in a universal testing machine. Results: Penetration of monomer into dentin via dentinal tubules was observed as moderate in the group of 0.07, 0.08, 0.09% and 0.1%. On the other hand, in the group of 0.2%, the color of Rhodamine B was too dark to identify the details of the dentinal tubules. There was no significant difference in the MTBS between the group of 0.05, 0.06 or 0.07% and control (p>0.05). The MTBS produced by the group 0.08, 0.09, 0.1% or 0.2% were significantly different from control (p<0.05). Conclusion: This study suggested that the application of CLSM was effective to evaluate penetration of self-etching primer to dentin. A high concentration of Rhodamine B influenced the bond strength. It was suggested that the appropriate concentration of Rhodamine B was 0.07% in the Mega Bond FA Primer.

    DOI: 10.11471/shikahozon.56.310

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  • リコンビナントヒトBMP-2を成体ラットに移植した場合の骨形成に対する低出力超音波パルスの影響(共著)

    山路公造, 小田島朝臣, 伊澤俊次, 田中久美子, 大原直子, 吉山昌宏

    日本歯科保存学雑誌   56 ( 4 )   318 - 324   2013

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    目的:低出力超音波パルス(Low-intensity Pulsed Ultrasound,LIPUS)は,骨形成を促し治癒を促進させることが知られており,現在骨折の治療などに臨床応用されている.本研究は増殖因子であるリコンビナントヒトBMP-2(rhBMP-2)を成体ラットの口蓋部骨膜下に移植しLIPUS照射を施した場合,骨形成にどのような影響を及ぼすか検討する目的で行った.材料と方法:15週齢ウィスター系雄性ラットの口蓋粘膜を.離後,rhBMP-2を配合したポリ乳酸グリコール酸共重合体/ゼラチンスポンジ複合体(配合比1.0μg/μl)を移植し,LIPUSを照射した場合(LI-BMP群)と,照射しない場合(BMP群)のグループに分けた.また,何も移植せずにLIPUSを照射した場合(LI群)と,照射しない場合(Cont群)のグループに分けた.LIPUSの照射条件は1.0MHz,240mW,照射時間5分間とし,移植後から観察期間終了まで3日ごとに照射を行った.観察期間は3週間とした.成績:LI-BMP群とBMP群の新生骨は,LI群およびCont群と比べて有意に多かった(p<0.05).LI-BMP群とBMP群間には有意差は認められなかった(p>0.05).また,BMP群の新生骨は既存骨と明瞭な境界で接していたのに対して,LI-BMP群では緻密な構造を有し既存骨とほとんど一体化していた.結論:以上の結果,rhBMP-2を成体ラットの口蓋部骨膜下に移植した場合,低出力超音波パルスを照射することにより新生骨形成が促進され,早期に既存骨と一体化する可能性が示唆された.(著者抄録)

    DOI: 10.11471/shikahozon.56.318

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J01092&link_issn=&doc_id=20130910220006&doc_link_id=%2Fdo1conde%2F2013%2F005604%2F006%2F0318-0324%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdo1conde%2F2013%2F005604%2F006%2F0318-0324%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 嚥下障害を有する岡山大学病院頭頸部がんセンターの患者に対して厳重なラバーダム装着がコンポジットレジン修復に有効であった症例(共著)

    田中久美子, 遠藤梓, 水川展吉, 吉山昌宏

    岡山歯学会雑誌   32 ( 2 )   65 - 70   2013

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  • Bonding to NaOCl-treated Dentin: Effect of Pretreatment with Sodium Toluene Sulfinic Acid

    Xianghong Li, Weidong Ma, Xiaodong Chen, Jiaming Zhao, Takashi Nakata, Kumiko Tanaka, Kei Takahashi, Yoshihiro Nishitani, Masahiro Yoshiyama

    JOURNAL OF ADHESIVE DENTISTRY   14 ( 2 )   129 - 136   2012.4

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    Purpose: The use of sodium hypochlorite (NaOCl) can decrease the bond strength of 4-META/MMA-TBB resin cement to root dentin. The aim of this in vitro study was to evaluate the effect of sodium toluene sulfinic acid (SA) as a pretreatment to increase bond strength to NaOCl-treated dentin.
    Materials and Methods: The root canal dentin of bovine teeth was treated with 6 methods: group 10-3 (10% citric acid/3% ferric chloride; control); group SA; group NC (sodium hypochlorite/10-3 solution); group NS-10-3 (NaOCl + sulfinic acid + 10-3 solution); group HSA-10-3 (NaOCl + H2O2 + NaOCl + sulfinic acid + 10-3 solution); group H0-10-3 (NaOCl + H2O2 + NaOCl + 10-3 solution). The roots were then filled with Super-Bond C&B (SB) or Super-Bond sealer (SBS). Samples were stored in distilled water for 24 h at 37 degrees C and then cross sectioned into five slabs (0.8 mm thick) that were subjected to "trimming" microtensile bond strength testing. All treated dentin surfaces and resin/dentin bond interfaces were analyzed under SEM.
    Results: Compared with the control, NaOCl treatment significantly decreased the resin/dentin bond strengths. However, SA treatment following NaOCl irrigation resulted in no significant differences of bond strength values.
    Conclusion: Sulfinic acid was effective in restoring 4-META/MMA-TBB resin cement bond strength after NaOCl irrigation.

    DOI: 10.3290/j.jad.a22090

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  • Bonding of Three Self-etching Priming Adhesive Systems to Bur-cut, Er:YAG-lased and Ultrasonic Vibrated Dentin

    NISHITANI Yoshihiro, ITOTA Toshiyuki, HOSHIKA Tomohiro, TAKAHASHI Kei, TANAKA Kumiko, MORIMOTO Sayako, IZAWA Syunji, YAMAJI Kozo, TORII Yasuhiro, YOSHIYAMA Masahiro

    54 ( 4 )   276 - 288   2011

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    The purpose of this study was to evaluate the effect of the method of removing carious dentin on resin-composite bond strengths to dentin using three self-etching adhesive systems: G-Bond (GC), One-up Bond F (Tokuyama Dental) or Clearfil Mega Bond (Kuraray Medical). The bur-cut, Er: YAG-lased and ultrasonic vibrated dentin was subjected to micro-tensile bond testing and observation of ultra-structure by scanning electron microscopy. A smear layer was not formed on the dentin surface after removing carious dentin in the case of Er: YAG-lased and ultrasonic vibrated dentin. Clearfil Mega Bond showed significantly higher micro-tensile bond strength to bur-cut and ultrasonic vibrated dentin compared with Er: YAG-lased dentin (p<0.05). One-up Bond F showed significantly higher micro-tensile bond strength to ultrasonic vibrated dentin compared with bur-cut and Er: YAG-lased dentin (p<0.05). It is suggested that the method of removing carious dentin by an ultrasonic vibration device is useful for dentin adhesion when using self-etching adhesive systems.

    DOI: 10.11471/shikahozon.54.276

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  • Neutralizing effect by resin-based materials containing silane-coated glass fillers

    Toshiyuki Itota, Toshiyuki Nakatsuka, Kumiko Tanaka, Yoko Tashiro, John F. McCabe, Masahiro Yoshiyama

    DENTAL MATERIALS JOURNAL   29 ( 4 )   362 - 368   2010.7

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    The aim of this study was to evaluate the fluoride release, neutralizing ability and inhibitory effect on secondary caries of resin-based materials containing a silane-coated glass filler. Resin-based materials containing fluoro-boro-alumino-silicate glass coated by 3-methacryloxypropyltrimethoxysilane or 3-a minopropyltrimethoxysilane were used and resin material containing glass filler without coating was used as a control. The fluoride release and pH value after immersion were measured for 10 weeks. The inhibitory effect was also evaluated. During the initial period, the material with 3-aminopropyltrimethoxysilane gave the greater amount of fluoride release and produced a higher pH value compared with the other materials. However, the neutralizing ability of the material with 3-aminopropyltrimethoxysilane filler became weaker with ageing of the specimens. The mean depth of outer lesions was similar among the three materials. Within the limitations of this study, secondary caries around restorations could not be inhibited even for products showing high fluoride releasing and neutralizing ability.

    DOI: 10.4012/dmj.2009-108

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  • 各種漂白剤処理後のエナメル質に対する接着性の検討.(共著)

    岸本麻実, 神農泰生, 穴吹優佳, 中田 貴, 田中久美子, 西谷佳浩, 吉山昌宏

    日本歯科保存学雑誌   53 ( 6 )   585 - 591   2010

  • XPS analysis of the dentin irradiated by Er:YAG laser

    Masanori Omae, Yasuo Shinnou, Kumiko Tanaka, Tomoko Abo, Takashi Nakata, Koichiro Suzuki, Yoshinori Hatsuoka, Naohiro Iwata, Kazushi Yoshikawa, Yoshihiro Nishitani, Kazuyo Yamamoto, Masahiro Yoshiyama

    DENTAL MATERIALS JOURNAL   28 ( 4 )   471 - 476   2009.7

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    The aim of this study was to investigate the effect of Er:YAG laser irradiation on human dentin surface using X-ray photoelectron spectroscopy (XPS). 10 human dentin disks were prepared from extracted human molars for XPS analysis. These specimens were divided into two groups of five: a control group and group that were irradiated by an Er:YAG laser beam (1.00 mJ, 1Hz). All specimens were analyzed by XPS over a wide scanning range and narrow scanning ranges. The Ca/P ratio was calculated from the XPS results.
    In the results, the binding energies of Ca, P, and N in the laser-irradiated group were higher than those in the control group. The Ca/P ratio of the Er:YAG laser irradiated group (1.24 +/- 0.05) was significantly lower than that of the control group (1.52 +/- 0.16). This study showed that Er:YAG laser irradiation decreased Ca/P ratio and denatured the collagen of human dentin.

    DOI: 10.4012/dmj.28.471

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  • ワンボトルセルフエッチングシステムの脱灰および再石灰化象牙質に対する接着.(共著)

    田中久美子, 西谷佳浩, 高橋 圭, 星加知宏, 吉山昌宏

    日本歯科保存学雑誌   52 ( 1 )   94 - 102   2009

  • フロアブルコンポジットレジンのフロー性に関する研究.(共著)

    星加知宏, 西谷佳浩, 高橋 圭, 田中久美子, 中田 貴, 山路公造, 吉山昌宏

    接着歯学   27 ( 3 )   118 - 124   2009

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  • 再石灰化象牙質に対するワンステップ接着システムの接着性.

    田中久美子

    岡山歯学会雑誌   28 ( 1 )   1 - 12   2009

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  • The effect of different mixing methods of self-adhesive luting cements on bonding to ceramics

    ABO Tomoko, UNO Shigeru, YAMADA Toshimoto, TANAKA Kumiko, TAKAHASHI Kei, NISHITANI Yoshihiro, YOSHIYAMA Masahiro

    Adhes. Dent.   26 ( 2 )   106 - 111   2008

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    The purpose of this study was to investigate the effect of mixing technique on the bond strengths of self-adhesive luting cements between ceramics and core resins.<BR>Resin core blocks (Clearfil DC Core Automix) created in a mold and ceramic blocks (Vitablocs Mark II) were ground with #600 SiC paper to standardize the surface roughness. These blocks were bonded with one of the three self-adhesive luting cements (Smartcem, Maxcem and G-CEM), according to the manufacturers' instructions. Two techniques, auto-mixing with mixing tips or auto-mixing apparatus and hand-mixing with a spatula, were assigned for cement mixing. In order to standardize the cement thickness to 50 μm, masking tape was placed on the surfaces of the ceramics. After 24 hours' storage in water at 37°C, the specimens were trimmed to a beam shape (1.0×1.0mm2) and subjected to micro-tensile bond strength measurements. For each group, 10specimens were measured. The data were statistically analyzed with Tukey's HSD test.<BR>The results showed no difference in mixing technique of self-adhesive luting cements on the bond strength between resin core blocks and ceramics blocks (p>0.05).

    DOI: 10.11297/adhesdent1983.26.106

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  • Effects of resin hydrophilicity on dentin bonds

    NISHITANI Yoshihiro, TAKAHASHI Kei, HAYASHI Yukinori, HOSHIKA Tomohiro, HORIKAWA Gen, NAKATA Takashi, TANAKA Kumiko, SANO Hidehiko, YOSHIYAMA Masahiro

    Adhes. Dent.   26 ( 2 )   92 - 98   2008

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    The purpose of this study was to determine the effects of resin hydrophilicity on dentin bonds. The study examined the microtensile bond strength of six experimental self-etching primers and two experimental bonds (50wt% ethanol/50wt% comonomers) of various degrees of hydrophilicity, that is various degrees of HEMA, to intact dentin. Following composite buildup, hourglass-shaped slabs were prepared from the bonded teeth for microtensile testing after24hours or6months. Higher bond strengths were achieved with increased resin hydrophilicity after 24hours, while the lowest bond strengths were achieved with increased resin hydrophilicity after6months. Measurements of water sorption/solubility of the polymers that were previously described showed high correlations between water sorption and the degree of HEMA, and between polymer solubility and the degree of HEMA.<BR>These results indicated that higher resin hydrophilicity was effective for short-term microtensile strength, while increased resin hydrophilicity may cause lower bond strength due to the weakness of polymers that have absorbed water after 6 months.

    DOI: 10.11297/adhesdent1983.26.92

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  • Effect of one-bottle bonding material "Absolute 2" on adhesion to contaminated dental hard tissues

    TAKAHASHI Kei, NISHITANI Yoshihiro, HOSHIKA Tomohiro, TANAKA Kumiko, YOSHIYAMA Masahiro

    Adhes. Dent.   26 ( 2 )   99 - 105   2008

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    This study investigated the effect of the one-bottle bonding material "Absolute2" (Dentsply Sankin) on adhesion to contaminated dental hard tissues with artificial saliva and fetal bovine serum. Enamel and dentin discs were prepared from freshly extracted human premolars and the buccal surfaces were ground with #600 SiC paper under running water in this study. The contaminated dental hard tissues were made by dripping artificial saliva or fetal bovine serum of twenty milliliters for twenty seconds, and the control was dripped with distilled water of twenty milliliters for twenty seconds. The debonded specimens, resin-enamel and resin-dentin interfaces, and the enamel and dentin surfaces treated with Absolute2were observed by SEM.<BR>The results showed no significant difference in bond strengths among all the groups. There were no morphological differences among all the groups by SEM observation. Cohesive failure in enamel as well as mixed failure were observed. Cohesive failure in dentin as well as mixed failure were observed in many cases in the debonded dentin group.<BR>The results indicated that Absolute showed satisfactory adhesion to the contaminated hard tissues with artificial saliva and fetal bovine serum.

    DOI: 10.11297/adhesdent1983.26.99

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  • Bonding of self-etching adhesive systems to demineralized and remineralized dentin

    TANAKA Kumiko, DOI Junichi, TAKABATAKE Yasumitsu, NISHITANI Yoshihiro, YAMAJI Kozo, ITOTA Toshiyuki, YOSHIYAMA Masahiro

    Adhesive Dentistry   25 ( 1 )   12 - 18   2007

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    This study investigated the bond strengths of one-or two-step self-etching adhesive systems to human sound, demineralized and remineralized dentin. Remineralized dentin was created by remineralization for1or4weeks after demineralization. The dentin surfaces were treated with Clearfil SE Bond or Clearfil Tri-S Bond and the microtensile bond strengths were measured. There were no significant differences in the bond strength of Clearfil SE Bond among the three groups (demineralized, 1-week and4-week remineralized dentin groups) except for the sound dentin group. On the other hand, the bond strength of Clearfil Tri-S Bond to1-week remineralized dentin was significantly higher than those to demineralized dentin and4-week remineralized dentin. In comparing the two adhesive systems, Clearfil SE Bond produced higher bond strengths to all dentin surfaces than Clearfil Tri-S Bond. In conclusion, it is suggested that the difference of the adhesive system affected the bond strength to demineralized and remineralized dentin.

    DOI: 10.11297/adhesdent1983.25.12

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  • 歯ブラシの刷毛部の長さの違いによる開口量別歯垢除去効果

    藤代 万由, 松崎 久美子, 吉田 陽子, 梶谷 明子, 佐々木 禎子, 三浦 留美, 宮崎 文伸, 吉山 昌宏, 浅海 淳一

    日本がん口腔支持療法学会 第8回学術大会  2022.12.17 

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    Event date: 2022.12.17 - 2022.12.18

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 各種レジンコア材料の光照射の有無が象牙質接着強さに及ぼす影響

    大原直子, 井内有人, 小野瀬里奈, 横山章人, 松崎久美子, 山路公造, 吉山昌宏

    第157回日本歯科保存学会2022年度秋季学術大会  2022.11.11 

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    Event date: 2022.11.10 - 2022.11.11

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  • BMP-2 配合ゼラチンゲルをエストロゲン欠乏ラットの口蓋部に 移植した場合の硬組織反応

    横山 章人, 山路 公造, 松﨑 久美子, 大原 直子, 吉山 昌宏

    第3回象牙質歯髄治療学会 学術大会  2022.9.10 

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    Event date: 2022.9.10

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  • 骨粗鬆症モデルラットにBMP-2配合ゼラチンハイドロゲルを移植した場合の硬組織反応

    横山章人, 山路公造, 松崎久美子, 大原直子, 吉山昌宏

    第156回日本歯科保存学会2022年度春季学術大会  2022.6.16 

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    Event date: 2022.6.16 - 2022.6.29

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  • 新規ユニバーサル・ボンディング材の象牙質接着性

    大原直子, 小野瀬里奈, 澁谷和彦, 横山章人, 松崎久美子, 山路公造, 吉山昌宏

    第156回日本歯科保存学会2022年度春季学術大会  2022.6.16 

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    Event date: 2022.6.16 - 2022.6.29

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  • 新規2ステップボンディング材の象牙質への接着耐久性

    大原直子, 小野瀬里奈, 澁谷和彦, 横山章人, 松﨑久美子, 山路公造, 吉山昌宏

    第154回日本歯科保存学会2021年度春季学術大会  2022.6.10 

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    Event date: 2022.6.10 - 2022.6.23

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  • 放射線性う蝕罹患リスクが高い頭頸部癌患者に治療前から継続的に口腔管理を行った一例

    吉田陽子, 松﨑久美子, 藤代万由, 中本美保, 佐々木禎子, 梶谷明子, 三浦留美, 宮崎文伸, 吉山昌宏, 浅海淳一

    日本がん口腔支持療法学会 第7回学術大会  2021.12.4 

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    Event date: 2021.12.4 - 2021.12.5

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  • 低出力超音波パルスがBMP-2配合ゼラチンハイドロゲルを口蓋部に注入した場合の骨形成に及ぼす影響

    山路公造, 横山章人, 松﨑久美子, 大原直子, 吉山知宏, 菅谷 勉, 島田康史, 吉山昌宏

    第155回日本歯科保存学会2021年度秋季学術大会  2021.10.28 

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    Event date: 2021.10.28 - 2021.11.10

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  • 新規2ステップシステムにおけるボンド塗布後のエアーブロー圧が象牙質接着性に及ぼす影響

    大原直子, 小野瀬里奈, 澁谷和彦, 横山章人, 松﨑久美子, 山路公造, 吉山昌宏

    第155回日本歯科保存学会2021年度秋季学術大会  2021.10.28 

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    Event date: 2021.10.28 - 2021.11.10

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  • 早期頬粘膜癌に対する高線量率RALSによる腔内照射(モールド法)の1例

    松崎秀信, 勝井邦彰, 武田斉子, 松崎久美子, 吉山昌宏, 浅海淳一

    第45回日本頭頸部癌学会  2021.6.17 

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    Event date: 2021.6.17 - 2021.6.18

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  • 歯科テクニックを使用した高線量率RALSによるモールド法での口唇癌の治療

    松?秀信、宮崎文伸、松?久美子、他7名

    日本がん口腔支持療法学会 第6回学術大会  光永幸代

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    Event date: 2020.12.5 - 2020.12.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:オンラインLIVE  

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  • 放射線性う蝕の抑制に関する検討

    松?久美子、小野瀬里奈、藤代万由、他7名

    日本がん口腔支持療法学会 第6回学術大会  光永幸代

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    Event date: 2020.12.5 - 2020.12.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンラインLIVE  

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  • エストロゲン欠乏ラットにBMP配合ゼラチンゲルを移植した場合の硬組織反応

    横山章人、山路公造、松?久美子、他4名

    第18回日本再生歯科医学会学術大会  日本歯科大学生命歯学部歯科保存学講座 五十嵐 勝

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    Event date: 2020.11.28

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催  

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  • 構造色発色フロアブルコンポジットレジンの色調適合性

    小野瀬里奈、大原直子、松崎久美子、他5名

    日本歯科保存学会 2020年度秋季学術大会  横瀬敏志

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    Event date: 2020.11.16 - 2020.11.30

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Web開催  

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  • 塩化ストロンチウム配合象牙質知覚過敏抑制材の脱灰抑制効果

    松?久美子、佐藤奈月、神農泰生、山路公造、大原直子、島田康史、Sadr Alireza、角 保徳、田上順次、吉山昌宏

    第152日本歯科保存学会学術大会 

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    Event date: 2020.6.11 - 2020.6.12

    Presentation type:Poster presentation  

    Venue:Web開催  

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  • BMP配合ゼラチンゲルをラット口蓋部に移植した場合の硬組織反応

    山路公造, 横山章人, 島田康史, 大原直子, 松崎久美子, 西山依理子, 田畑泰彦, 吉山昌宏

    第16回日本再生歯科医学会学術大会 

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    Event date: 2019.11.30 - 2019.12.1

    Presentation type:Poster presentation  

    Venue:愛知学院大学歯学部  

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  • 3Dプリンターを使用した放射線治療用マウスピースの試作

    松?秀信,宮崎文伸,松?久美子,青山英樹,竹内哲男,上田明広,勝井邦彰,吉山昌宏,浅海淳一

    日本がん口腔支持療法学会 第5回学術大会 

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    Event date: 2019.11.30 - 2019.12.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立がん研究センター, 東京  

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  • 脳腫瘍の強度変調放射線治療におけるマウスピースの有用性に関する検討

    松?秀信,青山英樹,宮崎文伸,松?久美子,田平 亮,渡邉謙太,片山敬久,勝井邦彰,吉山昌宏,浅海淳一

    日本がん口腔支持療法学会 第5回学術大会 

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    Event date: 2019.11.30 - 2019.12.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立がん研究センター,東京  

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  • PCA配合歯磨剤のレジン象牙質接着性への影響の検討

    吉山昌宏, 大原直子, 松崎久美子

    第151回日本歯科保存学会学術大会 

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    Event date: 2019.11.7 - 2019.11.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡  

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  • BMP配合アルギン酸ゲルを直接覆髄に用いた場合の硬組織形成

    横山章人, 山路公造, 塩出信太郎, 大原直子, 松?久美子, 島田康史, 吉山昌宏

    第151回日本歯科保存学会学術大会 

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    Event date: 2019.11.7 - 2019.11.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡  

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  • 頭頚部癌化学放射線療法後に発症した放射線性う蝕の1例

    松?久美子, 大原直子, 澁谷和彦, 横山章人, 山路公造, 島田康史, 木股敬裕, 吉山昌宏

    第151回日本歯科保存学会学術大会 

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    Event date: 2019.11.7 - 2019.11.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡  

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  • 放射線性う蝕に対するう蝕進行抑制含嗽液の開発

    松?久美子,松?秀信,勝井邦彰,久保和子,假谷 伸,木股敬裕,吉山昌宏

    第35回日本歯医学会 集い  日本歯科医学会

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    Event date: 2019.8.28

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • 象牙質およびコア用レジンに対するシランカップリング剤含有レジンセメントの接着強さ International conference

    大原直子, 小野瀬里奈, 澁谷和彦, 横山章人, 松崎久美子, 山路公造, 吉山昌宏

    第150回日本歯科保存学会学術大会 

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    Event date: 2019.6.27 - 2019.6.28

    Language:Japanese   Presentation type:Poster presentation  

    Venue:金沢  

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  • 着色象牙質を残置させた窩洞に対する新規コンポジットレジン(ECM-001)修復の色調評価

    小野瀬里奈, 大原直子, 澁谷和彦, 松崎久美子, 神農泰生, 島田康史, 吉山昌宏

    第150回日本歯科保存学会学術大会 

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    Event date: 2019.6.27 - 2019.6.28

    Language:Japanese   Presentation type:Poster presentation  

    Venue:金沢  

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  • Influence of Silver Diamine Fluoride on Bond Strengths to Caries-affected Dentin International conference

    Ohara Naoko, Matsuzaki Kumiko, Shibuya Kazuhiko, Ono Serina, Yokoyama Akihito, Yamaji Kozo, Yoshiyama Masahiro

    97th IADR General Session 

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    Event date: 2019.6.22

    Presentation type:Poster presentation  

    Venue:Vancouver, BC, Canada  

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  • 頭頸部癌患者における強度変調放射線治療中の体重減少に関する検討

    松?秀信,勝井邦彰,松?久美子,水川展吉,假谷 伸,木股敬裕, 他3名

    第43回日本頭頸部癌学会 

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    Event date: 2019.6.13 - 2019.6.14

    Language:Japanese   Presentation type:Poster presentation  

    Venue:金沢  

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  • 頭頸部癌放射線治療後の患者の口腔内の現状と唾液腺再生をめざして

    松崎久美子

    再生歯科シンポジウム岡山  岡山大学

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    Event date: 2019.5.26

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:岡山大学  

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  • 当院で経験した放射線う蝕の3例

    松崎久美子,松崎秀信,志茂加代子,青山英樹,宮崎文伸,勝井邦彰,木股敬裕,吉山昌宏

    日本がん口腔支持療法学会 第4回学術大会  新潟大学

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    Event date: 2018.12.1 - 2018.12.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:新潟  

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  • 当院における放射線顎骨壊死の検討

    松? 秀信、松?久美子、青山 英樹、志茂加代子、勝井 邦彰、吉山 昌宏 、浅海 淳一、木股 敬裕

    日本がん口腔支持療法学会 第4回学術大会  新潟大学

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    Event date: 2018.12.1 - 2018.12.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:新潟  

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  • BMP配合ゼラチンゲルをラット口蓋部に移植した場合の硬組織反応

    山路公造, 横山章人, 島田康史, 大原直子, 松崎久美子, 西山依理子, 田畑泰彦, 吉山昌宏

    第16回日本再生歯科医学会  愛知学院大学

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    Event date: 2018.12.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋  

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  • 化学重合型接着材ボンドマーライトレスを用いたコンポジットレジン修復の窩洞適合性のSS-OCT評価

    横山章人, 山路公造, 島田康史, 松崎久美子, 大原直子, 神農泰生, 高橋 圭, Sadr Alireza, 角保 徳, 田上順次, 吉山昌宏

    第149回日本歯科保存学会  愛知学院大学

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    Event date: 2018.11.1 - 2018.11.2

    Presentation type:Poster presentation  

    Venue:京都  

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  • フッ化ジアンミン銀塗布がう蝕象牙質の接着に及ぼす影響

    大原直子, 松崎久美子, 澁谷和彦, 小野瀬里奈, 横山章人, 山路公造, 吉山昌宏

    第149回日本歯科保存学会  愛知学院大学

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    Event date: 2018.11.1 - 2018.11.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都  

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  • 透明根管模型を使用した根管充填の評価に関する検討

    松崎久美子, 大原直子, 澁谷和彦, 横山章人, 岡田俊輔, 村上 純, 久富美紀, 浅海淳一, 吉山昌宏

    第39回岡山歯学会  岡山大学

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    Event date: 2018.10.21

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山大学  

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  • The influence of dry and wet conditions on filling materials International conference

    Shibuya Kazuhiko, Ohara Naoko, Matsuzaki Kumiko, Shimada Yasushi, Yoshiyama Masahiro

    96th IADR General Session  London

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    Event date: 2018.7.25 - 2018.7.28

    Language:English   Presentation type:Poster presentation  

    Venue:London  

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  • SS-OCTを用いた象牙質知覚過敏抑制材の脱灰抑制効果の評価

    松崎久美子, 横山章人, 高橋 圭, 神農泰生, 大原直子, 島田康史, Sadr Alireza, 角 保徳, 田上順次, 吉山昌宏

    第148回日本歯科保存学会  神奈川歯科大学

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    Event date: 2018.6.14 - 2018.6.15

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜  

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  • 亜鉛ガラス含有グラスアイオノマーセメントによる根面う蝕抑制効果の検討

    高橋 圭, 島田康史, 神農泰生, 松崎久美子, 横山章人, 田上順次, 吉山昌宏

    第148回日本歯科保存学会  神奈川歯科大学

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    Event date: 2018.6.14 - 2018.6.15

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜  

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  • 歯の色調とSS-OCT解析データの相関

    神農泰生, 島田康史, 松崎久美子, 高橋圭, 横山章人, Sadr Alireza, 角 保徳, 田上順次, 吉山昌宏

    第148回日本歯科保存学会  神奈川歯科大学

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    Event date: 2018.6.14 - 2018.6.15

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜  

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  • optical assessment of bleached enamel surface using SS-OCT International conference

    Yasuo Sinnno, Yasushi Shimada, , Kumiko Matsuzaki, others

    OCT国際シンポジウム岡山  2017  岡山大学 歯科保存修復学分野 吉山昌宏教授

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    Event date: 2017.11.30

    Language:English   Presentation type:Oral presentation (general)  

    Venue:岡山大学Jホール  

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  • 3D assessment of dental caries using SS-OCT International conference

    Yasushi Shimada, Yasuo Sinnno, Kumiko Matsuzaki, others

    OCT国際シンポジウム岡山  2017  岡山大学 歯科保存修復学分野 吉山昌宏教授

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    Event date: 2017.11.30

    Language:English   Presentation type:Oral presentation (general)  

    Venue:岡山大学Jホール  

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  • Assessment of surface contamination of uncured composite resin using SS-OCT International conference

    Akihito Yokoyama, Yasuo Sinnno, Kumiko Matsuzaki, others

    OCT国際シンポジウム岡山  2017  岡山大学 歯科保存修復学分野 吉山昌宏教授

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    Event date: 2017.11.30

    Language:English   Presentation type:Oral presentation (general)  

    Venue:岡山大学Jホール  

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  • Optical analysis of dentin de/remineralization from a desensitizer using swept-source optical coherence tomography International conference

    Kumiko Matsuzaki, Yasushi Shimada, Yasuo Sinnno, ,others

    OCT国際シンポジウム岡山  2017  岡山大学 歯科保存修復学分野 吉山昌宏教授

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    Event date: 2017.11.30

    Language:English   Presentation type:Oral presentation (general)  

    Venue:岡山大学Jホール  

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  • optical assessment of dentin de/remineralization from a phosphate-based desensitizer using optical coherence tomography International conference

    Kumiko Matsuzaki, Yasuo Shinno, Masahiro Yoshiyama others

    日本歯科保存学会第147回秋季大会 日韓若手セッション  2017  岩手医科大学歯学部 野田守教授

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    Event date: 2017.10.26 - 2017.10.27

    Language:English   Presentation type:Oral presentation (general)  

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  • 口腔乾燥症モデル作製のための基礎的研究 吸水および乾燥による充填用材料の質量変化

    澁谷和彦,松崎久美子,大原直子,吉山昌宏 他

    日本歯科保存学会第147回秋季大会  2017  岩手医科大学歯学部 野田守教授

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    Event date: 2017.10.26 - 2017.10.27

    Language:Japanese   Presentation type:Poster presentation  

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  • スキャホールドが低出力超音波パルスとBMPを用いた骨形成に及ぼす影響

    山路公造,横山章人,松崎久美子,吉山昌宏 他

    第15回日本再生歯科医学会大会  2017  大阪歯科大学 歯科理工学 今井弘一教授

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    Event date: 2017.10.21

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪歯科大学  

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  • 直接覆髄にBMP配合アルギン酸ゲルを用いた場合の硬組織反応

    山路公造,横山章人,松崎久美子,吉山昌宏 他

    第15回日本再生歯科医学会大会  2017  大阪歯科大学 歯科理工学 今井弘一教授

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    Event date: 2017.10.21

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪歯科大学  

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  • 充填用コンポジットレジンの色調に関する検討

    大原直子,小野瀬里奈,松崎久美子,吉山昌宏 他

    日本歯科保存学会第146回春季大会  2017  昭和大学歯学部 真鍋厚史教授

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    Event date: 2017.6.8 - 2017.6.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:リンクステーションホール青森  

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  • Actinomyces属3菌種による歯根象牙質う蝕の誘発

    第140回日本歯科保存学会学術大会  2014 

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  • MDPおよびフッ化ナトリウムの配合が試作セルフアドヒーシブレジンセメントの吸水量および溶解量に及ぼす影響

    第139回日本歯科保存学会学術大会  2013 

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  • 多用途型歯面処理材の象牙質接着強さ

    第139回日本歯科保存学会学術大会  2013 

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  • 象牙質知覚過敏抑制材がセルフエッチング接着システムの接着性に及ぼす影響

    第139回日本歯科保存学会学術大会  2013 

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  • 新規化学重合型プライマーの象牙質接着性

    日本接着歯学会学術大会  2012 

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  • 再石灰化象牙質に対するセルフエッチング接着システムの接着性

    日本再生歯科医学会学術大会  2012 

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  • 口腔連鎖球菌による歯根象牙質う蝕の誘発

    第137回日本歯科保存学会学術大会  2012 

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  • MDPおよびフッ化ナトリウムの配合が試作レジンセメントに及ぼす影響

    第31回日本接着歯学会学術大会  2012 

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  • 各種根管充填用シーラーを用いた根管封鎖性に関する研究

    日本歯内療法学会学術大会  2011 

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  • 共焦点レーザー顕微鏡(CLSM)によるレジン-象牙質接着界面の観察

    日本歯科保存学会学術大会  2011 

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  • MDPおよびフッ化ナトリウムの配合が試作レジンセメントの象牙質接着強さに及ぼす影響

    日本歯科保存学会学術大会  2011 

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  • 歯質表面損失症候群の診断・治療法の開発 人工酸蝕歯の再石灰化とレジン接着性

    日本歯科保存学会学術大会  2011 

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  • セルフアドヒーシブレジンセメントにおける前処理が微小引張接着強さに及ぼす影響

    日本歯科保存学会学術大会  2011 

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  • 共焦点レーザー顕微鏡を用いたレジン-象牙質接着界面の観察

    第28回日本接着歯学会  2010 

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  • 新規化学重合型プライマー(DBC-510)の象牙質接着性

    日本歯科保存学会平成22年度秋季学術大会  2010 

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  • 最新の自己接着性レジンに関する研究

    日本歯科保存学会平成22年度秋季学術大会  2010 

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  • 歯質表面損失症候群の診断・治療法の開発とアンチエイジング歯学の確立

    日本歯科保存学会平成22年度秋季学術大会  2010 

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  • Observation of the Resin-dentin Interfacial Ultrastructure Using Confocal Laser Scanning Microscope

    2010 

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  • アスコルビン酸ナトリウム処理が漂白後のエナメル質接着に及ぼす影響

    第28回日本接着歯学会学術大会  2010 

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  • キトサンオリゴマーを配合した接着性レジンセメントの抗菌性の検討

    日本再生歯科医学会  2010 

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  • 超音波がBMP骨膜注入後の骨形成に及ぼす影響

    第8回日本再生歯科医学会大会  2010 

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  • 術者の経験が接着性レジンの象牙質への接着強さに及ぼす影響

    岡山歯学会学術大会  2009 

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  • 新規象牙質知覚過敏抑制材に関する微細形態学的研究

    第131回日本歯科保存学会 秋季学術大会  2009 

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  • セルフエッチングプライマーによる象牙質中のゼラチン分解酵素の活性化

    第30回岡山歯学会総会ならびに学術集会  2009 

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  • 術者の経験が接着性レジンの象牙質への接着強さに及ぼす影響

    第30回岡山歯学会総会ならびに学術集会  2009 

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  • セルフエッチングプライマーによる象牙質中のゼラチン分解酵素の活性化

    岡山歯学会学術大会  2009 

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  • 再石灰化象牙質に対するワンステップ接着システムの接着性

    日本接着歯学会学術大会  2009 

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  • 各種漂白剤処理後の時間経過がエナメル質接着におよぼす影響

    第130回日本歯科保存学会 春期学術大会  2009 

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  • オフィスホワイトニング後の時間経過がエナメル質に対する各種接着システムの接着強さに及ぼす影響

    第131回日本歯科保存学会 秋季学術大会  2009 

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  • Tensile strength of mineralized/demineralized human normal and carious dentin

    The 10th joint Meeting between KACD and JSCD  2008 

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  • オフィスホワイトニング後のエナメル質に対する各種接着システムの接着強さ

    日本歯科保存学会春季学術大会  2008 

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  • 試作ワンステップボンディング材GBA400の歯質表面粗さの違いによる接着強さへの影響

    第129回日本歯科保存学会 秋季学術大会  2008 

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  • Er:YAGレーザーを照射したう蝕影響象牙質へのレジン接着強さに関する研究

    第129回日本歯科保存学会 秋季学術大会  2008 

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  • pH緩衝能を有するフッ素徐放性レジンの開発

    第127回日本歯科保存学会 秋季学術大会  2007 

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  • 直接覆髄にrhBMP-2配合アルギン酸ゲルを用いた場合の組織反応

    第126回日本歯科保存学会 春季学術大会  2007 

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  • 還元剤処理が次亜塩素酸ナトリウム処理歯冠部象牙質に対する4-META/MMA-TBBレジンの接着性に及ぼす影響

    第126回日本歯科保存学会 春季学術大会  2007 

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  • 新規接着性モノマーを用いた1ステップ接着システムの接着性についての研究

    第126回日本歯科保存学会 春季学術大会  2007 

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  • Er:YAGレーザー照射後のう蝕影響象牙質に対する接着強さに関する研究

    第10回Er:YAGレーザー臨床研究会  2007 

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  • セルフエッチング接着システムの再石灰化象牙質に対する接着性(第2報)

    第127回日本歯科保存学会 秋季学術大会  2007 

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Research Projects

  • A new approach to the prevention of radiation-related caries

    Grant number:21K07596  2021.04 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    松崎 秀信, 吉尾 浩太郎, 松崎 久美子, 青山 英樹

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

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  • アルカリ産生性アクチノマイセス属細菌を応用したう蝕管理法の確立

    Grant number:20K09939  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    大原 直子, 松崎 久美子, 大原 直也, 吉山 昌宏

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

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  • 放射線う蝕の治療法の確立に向けたセルフエッチング接着システムの基礎的研究

    Grant number:19K10149  2019.04 - 2023.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    松崎 久美子, 吉山 昌宏, 島田 康史, 松崎 秀信

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

    頭頸部癌に対する放射線治療の晩期障害のひとつに、放射線う蝕が挙げられる。フッ化物塗布によるう蝕予防効果には限界があり、放射線う蝕は一度発症すると急速かつ多発的に進行する。そのため、応急的にう蝕進行抑制剤を塗布し、日を改めて接着システムを使用したコンポジットレジン修復を行うことが多い。しかし、う蝕進行抑制剤は、被着面である象牙質表面のコラーゲンを凝固させるため、接着システムのプライマーが充分に浸透しない可能性がある。その上、接着システムの研究は、通常、口腔内が湿潤であることを前提として検証される。しかし、われわれが行った疫学調査で、頭頸部癌放射線治療後の唾液は、正常値の約1/3の量で泡状、粘性であった。そこで、口腔内環境に適応した基礎研究が必要と考えた。
    本研究の計画では、①う蝕進行抑制剤塗布後の象牙質における脱灰抑制効果の検証、②異なる保管環境における接着試料体の接着性の検討、③研究Ⅱの接着性の向上に関する研究、の大きく3つの骨子で成り立っている。
    2019~2020年にかけて、①う蝕進行抑制剤塗布後の象牙質における脱灰抑制効果の検証を行う計画を立てていた。現在までに、亜鉛含有/非含有象牙質知覚過敏抑制剤による象牙質の脱灰抑制効果を、波長走査型光干渉断層計(SS-OCT)を用いて検証した。その結果、亜鉛含有の材料は、象牙質表面よりやや深い位置で脱灰抑制効果を発揮し、亜鉛非含有の材料は、象牙質表面で脱灰抑制効果を発揮する可能性が示された。また、市販の象牙質知覚過敏抑制剤に、4段階に濃度を変えた塩化ストロンチウムを配合したものを試作し、象牙質の脱灰抑制効果を検討している。

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  • The study of development of device manufacturing system for radiotherapy using 3D printer

    Grant number:16K11502  2016.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    MATSUZAKI Hidenobu

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

    In this study, we examined the usefulness of a mouthpiece-type device for intensity-modulated radiation therapy for the patients of head and neck cancer. And we prototyped a mouthpiece device using a 3D printer. As a result, the mouthpiece-type device was useful for reducing the set-up error of patients during intensity-modulated radiation therapy. In addition, the conformity of the mouthpiece-type device made by the 3D printer using the data of the optical impression was comparable to that of the conventional mouthpiece-type device. On the other hand, for clinical use, there are some problems of introduction costs of optical scanner, CAD software, and 3D printer. In addition, it is necessary to investigate the way of the reduction of metal artifacts when using CT images as a data source.

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  • Analysis of sealing mechanism of open dentin tubules and improvement of adhesion of self-etching adhesive system.

    Grant number:26462882  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    MATSUZAKI Kumiko

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    Grant amount:\4810000 ( Direct expense: \3700000 、 Indirect expense:\1110000 )

    We focused on the use of dentin desensitizers for wedge-shaped defect with dentin hypersensitivity symptoms and subsequent composite resin restoration. We evaluated dental adhesives of the dentin tubules opening models, which was coated with three types of commercially available dentin desensitizers, after primer treatment by self - etching adhesive system. As a result, morphological differences were observed on the dentin surface and resin-dentin interface. Although there were some characteristic patterns and differences in microleakage of the resin-dentin interface and penetration of the primer, that did not affect the bond strength of them.

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  • Studies on the blockade of dentinal tubules with dentin hypersensitivity model

    Grant number:24792025  2012.04 - 2014.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    TANAKA Kumiko

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    Grant amount:\3770000 ( Direct expense: \2900000 、 Indirect expense:\870000 )

    This study was to evaluate the effect on the adhesive system and blockade of dentinal tubules using the dentin hypersensitivity model and various dentin desensitizing agents. Application of the dentin desensitizing agents did not affect the adhesive of the self-etching adhesive system. The bond strength decreased in the thermal cycle, so the adhesive durability will have to be studied in future.

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  • The penetration and bonding of self-etching adhesive system to remineralized dentin

    Grant number:22791835  2010 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    TANAKA Kumiko

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    Grant amount:\3900000 ( Direct expense: \3000000 、 Indirect expense:\900000 )

    This study relates to the penetration of the adhesion system to dentin. The resin-dentin interface observed by Confocal laser scanning microscopy. The density of fluorescent-dye which was mixed with the adhesive system was identified in this study, so it was easy to observe the penetration. In this study, while the adhesive system in sound dentin permeated the dential tubules, that in the artificial remineralized dentin permeated little.

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Class subject in charge

  • Practices of cavity preparation, filling technique and metal inlay restoration (2022academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practice of the diagnosis and treatment of Dentin/Pulp Complex (2022academic year) Fourth semester  - 金5

  • Practices of cavity preparation, filling technique and metal inlay restoration (2021academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practice of the diagnosis and treatment of Dentin/Pulp Complex (2021academic year) Fourth semester  - 金5

  • Practices of cavity preparation, filling technique and metal inlay restoration (2020academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practices of cavity preparation, filling technique and metal inlay restoration (2020academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practice of the diagnosis and treatment of Dentin/Pulp Complex (2020academic year) Fourth semester  - 金5

  • Practices of cavity preparation, filling technique and metal inlay restoration (2019academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practice of the diagnosis and treatment of Dentin/Pulp Complex (2019academic year) Fourth semester  - 金5

  • Practices of cavity preparation, filling technique and metal inlay restoration (2018academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practice of the diagnosis and treatment of Dentin/Pulp Complex (2018academic year) Fourth semester  - 金5

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