Updated on 2025/09/30

写真a

 
Amano Katsuhiko
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
Position
Associate Professor
External link

Degree

  • 歯学博士 ( 大阪大学 )

Research Interests

  • Developmental Biology

  • Bone and Cartilage Metabolism

  • Cleft lip and palate

  • Craniomaxillofacial study

  • Oral surgery

  • Jaw deformity

  • Mouse genetics

Research Areas

  • Life Science / Surgical dentistry

  • Life Science / Developmental dentistry

Research History

  • Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences   Department of Oral and Maxillofacial Reconstructive Surgery   Associate Professor

    2023.3

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    Country：Japan

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  • Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences   Department of Oral and Maxillofacial Reconstructive Surgery   Lecturer

    2022.4 - 2023.2

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    Country：Japan

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  • Osaka University Graduate School of Dentistry   The first department of Oral and Maxillofacial Surgery   Assistant Professor

    2017.5 - 2022.3

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    Country：Japan

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  • 大阪大学歯学部附属病院   医員

    2015.7 - 2017.5

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    Country：Japan

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  • Harvard School of Dental Medicine   Research Fellow

    2013.1 - 2015.6

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    Country：United States

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  • Japan Society for the Promotion of Science   Harvard School of Dental Medicine

    2011.5 - 2012.12

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    Country：Japan

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Professional Memberships

 

Papers

  • The Endoscopic Removal of a Detached Dental Implant Cap in the Maxillary Sinus During the Waiting Period: A Case Report. Reviewed International journal

    Katsuhiko Amano, Chiaki Nishizawa, Yohei Maeda, Susumu Tanaka, Seiji Iida

    Cureus   16 ( 6 )   e63243   2024.6

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Displacement of dental implants into the maxillary sinus is one of the common dental complications. However, it is rare that dental implants cause the displacement of multiple components due to separation. Here, we describe an unusual case of a 43-year-old man who had a missing implant in the maxillary sinus after an implant procedure. There was a two-week waiting period before we performed the removal during which the cap had unexpectedly separated from the body and freely moved into the ostium by sinus activity. The body was independently extracted intraorally. The remaining cap was secondly removed by utilizing nasal endoscopy. There were no complications in the postoperative period and the patient reported no symptoms of sinusitis after two months of follow-up. We experience unexpected events in the course of treating a displaced implant into the maxillary sinus. Our case report may provide several learning points for the removal of a missing implant.

    DOI： 10.7759/cureus.63243

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  • A case of epidermoid cyst considered as originated from the abdominal skin tissue inserted into the temporomandibular joint 52 years ago Reviewed

    Soma Kato, Katsuhiko Amano, Norifumi Moritani, Yuki Nagata, Natsuki Segami, Seiji Iida

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   36 ( 3 )   354 - 358   2024.5

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ajoms.2023.08.015

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  • Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation Reviewed

    K. Amano, D. Okuzaki, Y. Kitaoka, S. Kato, M. Fujiwara, S. Tanaka, S. Iida

    Journal of Dental Research   103 ( 3 )   308 - 317   2024.3

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

    Neural crest cells (NCC) arise from the dorsal margin of the neural plate border and comprise a unique cell population that migrates to and creates the craniofacial region. Although factors including Shh, Fgf8, and bone morphogenetic proteins have been shown to regulate these biological events, the role of parathyroid hormone 1 receptor (Pth1r) has been less studied. We generated an NCC-specific mouse model for Pth1r and researched gene expression, function, and interaction focusing on nasal cartilage framework and midfacial development. Wnt1-Cre;Pth1r fl/ fl; Tomato fl/+ mice had perinatal lethality, but we observed short snout and jaws, tongue protrusion, reduced NCC-derived cranial length, increased mineralization in nasal septum and hyoid bones, and less bone mineralization at interfrontal suture in mutants at E18.5. Importantly, the mutant nasal septum and turbinate cartilage histologically revealed gradual, premature accelerated hypertrophic differentiation. We then studied the underlying molecular mechanisms by performing RNA seq analysis and unexpectedly found that expression of Ihh and related signaling molecules was enhanced in mutant nasomaxillary tissues. To see if Pth1r and Ihh signaling are associated, we generated a Wnt1-Cre; Ihh fl/ fl; Pth1r fl/ fl; Tomato fl/+ (DKO) mouse and compared the phenotypes to those of each single knockout mouse: Wnt1-Cre; Ihh fl/ fl; Pth1r fl/+; Tomato fl/+ (Ihh-CKO) and Wnt1-Cre;Ihh fl/+; Pth1r fl/ fl; Tomato fl/+ (Pth1r-CKO). Ihh-CKO mice displayed a milder effect. Of note, the excessive hypertrophic conversion of the nasal cartilage framework observed in Pth1r-CKO was somewhat rescued DKO embryos. Further, a half cAMP responsive element and the 4 similar sequences containing 2 mismatches were identified from the promoter to the first intron in Ihh gene. Gli1-Cre ERT2; Pth1r fl/ fl; Tomato fl/+, a Pth1r-deficient model targeted in hedgehog responsive cells, demonstrated the enlarged hypertrophic layer and significantly more Tomato-positive chondrocytes accumulated in the nasal septum and ethmoidal endochondral ossification. Collectively, the data suggest a relevant Pth1r/Ihh interaction. Our findings obtained from novel mouse models for Pth1r signaling illuminate previously unknown aspects in craniofacial biology and development.

    DOI： 10.1177/00220345231221954

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    Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/00220345231221954

  • 放射線性顎骨壊死18例における感染源と周術期口腔管理の効果についての検討 Reviewed

    武田斉子, 水川展吉, 田村庄平, 中田靖章, 天野克比古, 浅海淳一, 飯田征二

    岡山大学歯学会雑誌   42 ( 2 )   23 - 32   2023.12

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  • Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial Base Synchondrosis Reviewed

    K. Amano, Y. Kitaoka, S. Kato, M. Fujiwara, D. Okuzaki, T. Aikawa, M. Kogo, S. Iida

    Journal of Dental Research   102 ( 11 )   1241 - 1251   2023.10

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    DOI： 10.1177/00220345231184405

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  • 開窓術により治療した舌下型類皮嚢胞の１例 Reviewed

    武田斉子, 田村庄平, 天野克比古, 水川展吉, 高畠清文, 飯田征二

    日本口腔外科学会雑誌   69 ( 10 )   475 - 480   2023.10

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  • Mandibular condylar displacement and the associated factors following intraoral vertical ramus osteotomy Reviewed

    Yuki Nagata, Norifumi Moritani, Katsuhiko Amano, Yuki Arimura, Kazuki Nakatsuji, Soma Kato, Ayaka Mikami, Tatsushi Matsumura, Seiji Iida

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   35 ( 5 )   390 - 396   2023.9

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ajoms.2023.01.005

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  • A sporadic case of Gigantiform Cementoma with mild and atypical clinical manifestation. Reviewed

    Kasahara S, Amano K, Kurioka K, Minohara M, Kogo M, Tanaka S

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   35 ( 3 )   233 - 240   2023.5

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  • A case of a massive Desmoplastic Fibroblastoma on the mandibular gingiva. Reviewed

    Yasuda T, Amano K, Kawamura K, Cho J, Kogo M, Tanaka S

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   35 ( 2 )   172 - 177   2023.3

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  • Osteonecrosis of the Jaw in Two Rheumatoid Arthritis Patients Not Treated with a Bisphosphonate Reviewed

    Amano K, Sugauchi A, Yamada C, Kogo M, Iida S

    Acta Medica Okayama   77 ( 1 )   111 - 116   2023.2

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  • The secondary case of melanotic neuroectodermal tumor in the infant maxilla: Long-term observation after the enucleation. Reviewed

    Kurioka K, Amano K, Harada K, Okura M, Kogo M, Tanaka S

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   34 ( 5 )   599 - 604   2022.9

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    DOI： 10.1016/j.ajoms.2022.02.011

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  • Effects of Mechanical Stress and Deficiency of Dihydrotestosterone or 17β-Estradiol on Temporomandibular Joint Osteoarthritis in Mice Reviewed

    Tomohisa Ootake, Takenobu Ishii, Kenji Sueishi, Akira Watanabe, Yoichi Ishizuka, Katsuhiko Amano, Masashi Nagao, Kazuaki Nishimura, Yasushi Nishii

    Osteoarthritis and Cartilage   29 ( 11 )   1575 - 1589   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.joca.2021.08.005

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  • Indian hedgehog in craniofacial neural crest cells links to skeletal malocclusion by regulating associated cartilage formation and gene expression Reviewed

    Katsuhiko Amano, Daisuke Okuzaki, Tomonao Aikawa, Mikihiko Kogo

    FASEB Journal   34 ( 5 )   6791 - 6807   2020.5

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1096/fj.201903269R

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  • Performance status scale for head and neck scores for oral cancer survivors: predictors and factors for improving quality of life. Reviewed

    Kondo T., Sugauchi A., Yabuno Y., Kobashi H., Amano K., Aikawa T., Kogo M., Okura M.

    Clin Oral Investig.   23 ( 4 )   1575 - 1582   2019.4

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  • A case of modified Furlow palatoplasty applied to a Campomelic dysplasia patient Reviewed

    Amano K, Otsuki K, Kurioka K, Fujiwara M, Kogo M

    Journal of Oral and Maxillofacial Surgery, Medicine and Pathology   31 ( 2 )   81 - 85   2019.3

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    DOI： 10.1016/j.ajoms.2018.07.007

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  • 非定型口腔顔面裂に対し顔面形成術と口蓋形成術を行った1例 Reviewed

    小橋 寛薫, 大槻 浩一, 磯村 恵美子, 原田 丈司, 天野 克比古, 古郷 幹彦

    日本口腔外科学会雑誌   64 ( 7 )   434 - 438   2018.7

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(公社)日本口腔外科学会  

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  • Klotho expression in osteocytes regulates bone metabolism and controls bone formation Reviewed

    Hirotaka Komaba, Jovana Kaludjerovic, Dorothy Z. Hu, Kenichi Nagano, Katsuhiko Amano, Noriko Ide, Tadatoshi Sato, Michael J. Densmore, Jun-ichi Hanai, Hannes Olauson, Teresita Bellido, Tobias E. Larsson, Roland Baron, Beate Lanske

    KIDNEY INTERNATIONAL   92 ( 3 )   599 - 611   2017.9

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    DOI： 10.1016/j.kint.2017.02.014

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  • TGF-beta in jaw tumor fluids induces RANKL expression in stromal fibroblasts Reviewed

    Yamada C., Aikawa T., Okuno E., Miyagawa K., Amano K., Takahata S., Kimata M., Okura M., Iida S., Kogo M.

    International journal of oncology   49 ( 2 )   499 - 508   2016.8

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    DOI： 10.3892/ijo.2016.3548

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  • Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones Reviewed

    Katsuhiko Amano, Michael Densmore, Yi Fan, Beate Lanske

    BONE   83   256 - 266   2016.2

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    DOI： 10.1016/j.bone.2015.11.017

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  • Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation Reviewed

    Katsuhiko Amano, Michael J. Densmore, Beate Lanske

    JOURNAL OF BONE AND MINERAL RESEARCH   30 ( 12 )   2262 - 2272   2015.12

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    DOI： 10.1002/jbmr.2582

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  • Regulation of transcriptional network system during bone and cartilage development Reviewed

    Riko Nishimura, Kenji Hata, Fumiyo Ikeda, Takuma Matsubara, Katsuhiko Amano, Koichiro Ono, Yoko Takigawa, Rikako Takashima, Michiko Yoshida, Eriko Nakamura, Toshiyuki Yoneda

    Journal of Oral Biosciences   57 ( 4 )   165 - 170   2015.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    ? 2015 Japanese Association for Oral Biology. Background Bone and cartilage are essential skeletal tissues, which not only function as structural basis of locomotive organs, but also regulate calcium homeostasis, phosphate metabolism, hematopoiesis, and glucose turnover. Several hormones and cytokines in cooperation with their downstream transcription factors regulate bone and cartilage development; therefore, it is important to understand the precise mechanisms of this regulation. Highlight Genetic studies in human and mouse have provided a wealth of information regarding the transcription factors implicated in bone and cartilage development. Moreover, innovative molecular cloning techniques identified several new transcription factors that play indispensable roles in controlling the development of bone and cartilage. The mechanisms controlling the expression of these transcription factors have been meticulously elucidated, so that the transcriptional network system, which seemed so complex and mysterious not so long ago, has become considerably clearer in recent years. Conclusion Recent advances in our knowledge about transcriptional network systems contributed to understanding the molecular underpinnings of regulation and pathological disease mechanisms in bone and cartilage.

    DOI： 10.1016/j.job.2015.06.001

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  • Indian Hedgehog Signaling Regulates Transcription and Expression of Collagen Type X via Runx2/Smads Interactions Reviewed

    Katsuhiko Amano, Michael Densmore, Riko Nishimura, Beate Lanske

    JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 36 )   24898 - 24910   2014.9

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    DOI： 10.1074/jbc.M114.570507

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  • Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes Reviewed

    Kenji Hata, Rikako Takashima, Katsuhiko Amano, Koichiro Ono, Masako Nakanishi, Michiko Yoshida, Makoto Wakabayashi, Akio Matsuda, Yoshinobu Maeda, Yutaka Suzuki, Sumio Sugano, Robert H. Whitson, Riko Nishimura, Toshiyuki Yoneda

    Nature Communications   4   2850   2013.11

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    DOI： 10.1038/ncomms3850

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  • Cleft Lip in Oculodentodigital Dysplasia Suggests Novel Roles for Connexin43 Reviewed

    K. Amano, M. Ishiguchi, T. Aikawa, M. Kimata, N. Kishi, T. Fujimaki, A. Murakami, M. Kogo

    JOURNAL OF DENTAL RESEARCH   91 ( 7 )   S38 - S44   2012.7

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    DOI： 10.1177/0022034512447952

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  • Regulation of endochondral ossification by transcription factors Reviewed

    Riko Nishimura, Kenji Hata, Koichiro Ono, Katsuhiko Amano, Yoko Takigawa, Makoto Wakabayashi, Rikako Takashima, Toshiyuki Yoneda

    FRONTIERS IN BIOSCIENCE-LANDMARK   17   2657 - 2666   2012.6

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    DOI： 10.2741/4076

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  • Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription Reviewed

    Katsuhiko Amano, Kenji Hata, Shuji Muramatsu, Makoto Wakabayashi, Yoko Takigawa, Koichiro Ono, Masako Nakanishi, Rikako Takashima, Mikihiko Kogo, Akio Matsuda, Riko Nishimura, Toshiyuki Yoneda

    MOLECULAR BIOLOGY OF THE CELL   22 ( 8 )   1300 - 1311   2011.4

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    DOI： 10.1091/mbc.E10-07-0566

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  • The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9 Reviewed

    Yoko Takigawa, Kenji Hata, Shuji Muramatsu, Katsuhiko Amano, Koichiro Ono, Makoto Wakabayashi, Akio Matsuda, Kenji Takada, Riko Nishimura, Toshiyuki Yoneda

    JOURNAL OF CELL SCIENCE   123 ( 21 )   3780 - 3788   2010.11

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    DOI： 10.1242/jcs.071373

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  • Sox9 Family Members Negatively Regulate Maturation and Calcification of Chondrocytes through Up-Regulation of Parathyroid Hormone-related Protein Reviewed

    Katsuhiko Amano, Kenji Hata, Atsushi Sugita, Yoko Takigawa, Koichiro Ono, Makoto Wakabayashi, Mikihiko Kogo, Riko Nishimura, Toshiyuki Yoneda

    MOLECULAR BIOLOGY OF THE CELL   20 ( 21 )   4541 - 4551   2009.11

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    DOI： 10.1091/mbc.E09-03-0227

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  • Facial frontal morphological changes related to mandibular setback osteotomy using cephalograms. Reviewed International journal

    Katsuhiko Amano, Takakazu Yagi, Seiji Iida, Tomonao Aikawa, Takashi Yamashiro, Kenji Takada, Mikihiko Kogo

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery   37 ( 7 )   412 - 6   2009.10

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    AIM: The purpose of this study was to examine morphological changes of the mandibular region using frontal cephalograms following bilateral sagittal split osteotomy (BSSO) for mandibular setback. Furthermore, we compared the stability between screw and plate fixation. METHODS: Pre and postoperative frontal cephalograms were taken of 26 patients. Parameters, Angle "A" which is formed by constructed lines along the mandibular ramus, and mandibular width at the angle were calculated. The subjects were analyzed according to the types of bony fixation, whether by screws or plates. RESULTS: Angle "A" and mandibular angular width of total numbers did not widely change at early period following operation. Late postoperatively, mandibular width of total numbers decreased in conjunction with increasing Angle "A". When comparing the parameters between screw and plate groups, the plate group showed a decrease of Angle "A" as an early change. Late postoperatively, the plate group showed an increase of Angle "A" and a decrease of mandibular width, while the screw group had smaller changes. CONCLUSION: We demonstrate postoperative inclination of mandibular lower ramus towards the facial midline. We suggest that the types of rigid fixation have an influence on frontal skeletal morphology, namely that screw fixation has higher stability.

    DOI： 10.1016/j.jcms.2009.04.012

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  • A case of post-extraction hemorrhage as a complication of aneurysm-related chronic DIC Reviewed

    AMANO Katsuhiko, NOMURA Kimiko, ASAHI Yoshinao, OMICHI Shiro, KOGO Mikihiko

    Journal of Oral Surgery Society of Japan   54 ( 11 )   631 - 635   2008.11

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    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

    Since elderly patients with systemic diseases often undergo tooth extraction, it is difficult to predict the risk of and to optimally treat post-extraction hemorrhage. We report a rare case of persistent hemorrhage that occurred after tooth extraction caused by chronic disseminated intravascular coagulation (DIC) as a complication of dissecting aneurysm. A 69-year-old man who underwent extraction of a maxillary molar had persistent bleeding, which could not be stopped by continuous local treatment to promote hemostasis. After a general examination, we diagnosed chronic DIC caused by an extensive dissecting aneurysm, based on evidence of advanced fibrinogenolysis. Hemostasis was achieved by general treatment for chronic DIC. Appropriate diagnosis and treatment of both local and general conditions are necessary for post-extraction hemorrhage.

    DOI： 10.5794/jjoms.54.631

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    Other Link： https://jlc.jst.go.jp/DN/JALC/00322388084?from=CiNii

  • 内軟骨性骨形成の分子制御機構 Reviewed

    西村 理行, 波多 賢二, 天野 克比古, 滝川 陽子, 小野 孝一郎, 米田 俊之

    最新医学   63 ( 11 )   2170 - 2175   2008.11

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  • Msx2 Stimulates Chondrocyte Maturation by Controlling Ihh Expression Reviewed

    Katsuhiko Amano, Fumitaka Ichida, Atsushi Sugita, Kenji Hata, Masahiro Wada, Yoko Takigawa, Masako Nakanishi, Mikihiko Kogo, Riko Nishimura, Toshiyuki Yoneda

    JOURNAL OF BIOLOGICAL CHEMISTRY   283 ( 43 )   29513 - 29521   2008.10

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    DOI： 10.1074/jbc.M803681200

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  • Paraspeckle protein p54(nrb) links Sox9-mediated transcription with RNA processing during chondrogenesis in mice Reviewed

    Kenji Hata, Riko Nishimura, Shuji Muramatsu, Akio Matsuda, Takuma Matsubara, Katsuhiko Amano, Fumiyo Ikeda, Vincent R. Harley, Toshiyuki Yoneda

    JOURNAL OF CLINICAL INVESTIGATION   118 ( 9 )   3098 - 3108   2008.9

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    DOI： 10.1172/JCI31373

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  • Signal transduction and transcriptional regulation during mesenchymal cell differentiation Reviewed

    Riko Nishimura, Kenji Hata, Fumiyo Ikeda, Fumitaka Ichida, Atsuko Shimoyama, Takuma Matsubara, Masahiro Wada, Katsuhiko Amano, Toshiyuki Yoneda

    JOURNAL OF BONE AND MINERAL METABOLISM   26 ( 3 )   203 - 212   2008.5

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    DOI： 10.1007/s00774-007-0824-2

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  • Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation Reviewed

    Shuji Muramatsu, Makoto Wakabayashi, Takeshi Ohno, Katsuhiko Amano, Rika Ooishi, Toshinori Sugahara, Satoshi Shiojiri, Kosuke Tashiro, Yutaka Suzuki, Riko Nishimura, Satoru Kuhara, Sumio Sugano, Toshiyuki Yoneda, Akio Matsuda

    JOURNAL OF BIOLOGICAL CHEMISTRY   282 ( 44 )   32158 - 32167   2007.11

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    DOI： 10.1074/jbc.M706158200

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  • 軟骨分化過程におけるAridファミリー転写因子Mrf1の役割の解明 Reviewed

    天野 克比古

    大阪大学歯学雑誌   52 ( 1 )   1 - 12   2007.10

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    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Doctoral thesis  

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  • Ihh/Gli2 signaling promotes regulating Runx2 expression osteoblast differentiation by and function Reviewed

    Atsuko Shimoyama, Masahiro Wada, Fumiyo Ikeda, Kenji Hata, Takuma Matsubara, Akira Nifuji, Masaki Noda, Katsuhiko Amano, Akira Yamaguchi, Riko Nishimura, Toshiyuki Yoneda

    MOLECULAR BIOLOGY OF THE CELL   18 ( 7 )   2411 - 2418   2007.7

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    DOI： 10.1091/mbc.E06-08-0743

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  • Repeated distraction osteogenesis for excessive vertical alveolar augmentation: A case report Reviewed

    Seiji Iida, Tamaki Nakano, Katsuhiko Amano, Mikihiko Kogo

    International Journal of Oral and Maxillofacial Implants   21 ( 3 )   471 - 475   2006.5

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  • Involvement of the NMDA-nitric oxide pathway in the development of hypersensitivity to tactile stimulation in dental injured rats Reviewed

    N Yonehara, K Amano, Y Kamisaki

    JAPANESE JOURNAL OF PHARMACOLOGY   90 ( 2 )   145 - 155   2002.10

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    DOI： 10.1254/jjp.90.145

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  • Migrationにより下顎骨下縁より歯根が突出した異所性埋伏智歯の一例

    永田 裕樹, 天野 克比古, 武田 斉子, 中辻 和樹, 飯田 征二

    日本口腔科学会雑誌   73 ( 2 )   106 - 107   2024.9

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  • 歯性上顎洞炎に対する内視鏡下副鼻腔手術および歯科治療の治療効果に関する臨床的検討

    徳重 侑, 天野 克比古, 永田 裕樹, 武田 斉子, 田村 庄平, 中辻 和樹, 兵藤 藍子, 飯田 征二

    日本口腔科学会雑誌   73 ( 2 )   152 - 152   2024.9

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  • 安静時唾液の性状が味覚感受性に与える影響 唾液緩衝能による影響

    兵藤 藍子, 永田 裕樹, 天野 克比古, 武田 斉子, 田村 庄平, 中辻 和樹, 徳重 侑, 飯田 征二

    日本口腔科学会雑誌   73 ( 2 )   183 - 183   2024.9

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  • 当科における口唇口蓋裂症例に対する上顎骨骨延長術の応用

    有村 友紀, 天野 克比古, 中辻 和樹, 永田 裕樹, 加藤 壮真, 植田 紘貴, 上岡 寛, 飯田 征二

    日本顎変形症学会雑誌   34 ( 2 )   136 - 136   2024.5

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  • 4切歯を含む上顎歯槽骨切り術によって歯列不正を改善した2症例

    中辻 和樹, 天野 克比古, 谷本 裕子, 河野 加奈, 有村 友紀, 永田 裕樹, 加藤 壮真, 上岡 寛, 飯田 征二

    日本顎変形症学会雑誌   34 ( 2 )   191 - 191   2024.5

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  • 4切歯を含む上顎歯槽骨切り術によって歯列不正を改善した2症例

    中辻 和樹, 天野 克比古, 谷本 裕子, 河野 加奈, 有村 友紀, 永田 裕樹, 加藤 壮真, 上岡 寛, 飯田 征二

    日本顎変形症学会雑誌   34 ( 2 )   191 - 191   2024.5

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  • 当科における口唇口蓋裂症例に対する上顎骨骨延長術の応用

    有村 友紀, 天野 克比古, 中辻 和樹, 永田 裕樹, 加藤 壮真, 植田 紘貴, 上岡 寛, 飯田 征二

    日本顎変形症学会雑誌   34 ( 2 )   136 - 136   2024.5

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  • 扇型の上顎骨拡大により正常被蓋を獲得した片側性唇顎口蓋裂の3症例

    西谷 悠希, 有村 友紀, 天野 克比古, 兵藤 藍子, 植田 紘貴, 河野 加奈, 大久保 香織, 竹本 史子, 上岡 寛, 飯田 征二

    日本口蓋裂学会雑誌   49 ( 2 )   161 - 161   2024.4

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  • 充実部と嚢胞部が混在し診断に苦慮したエナメル上皮腫の1例

    舩橋 洋志, 天野 克比古, 岩本 悠希, 長尾 有里, 高畠 清文, 永田 裕樹, 飯田 征二

    日本口腔科学会雑誌   72 ( 4 )   258 - 258   2023.12

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  • 歯磨剤が含有するSLSに起因したと考えられた口腔粘膜剥離の1例

    西谷 悠希, 天野 克比古, 武田 斉子, 有村 友紀, 田村 庄平, 中辻 和樹, 永田 裕樹, 飯田 征二

    岡山歯学会雑誌   42 ( 2 )   69 - 69   2023.12

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  • 副甲状腺ホルモン受容体シグナルはマウス鼻軟骨の形成に必須である

    天野 克比古, 北岡 好大, 栗岡 恭子, 田中 晋, 飯田 征二

    日本口腔科学会雑誌   72 ( 2 )   151 - 151   2023.7

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  • 下顎枝垂直骨切り術による下顎頭の2次元的な位置変化の解析およびその変化に関与する因子の検討

    永田 裕樹, 天野 克比古, 森谷 徳文, 有村 友紀, 中辻 和樹, 加藤 壮真, 飯田 征二

    日本口腔科学会雑誌   72 ( 2 )   77 - 77   2023.7

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  • 下顎枝垂直骨切り術による下顎頭の2次元的な位置変化の解析およびその変化に関与する因子の検討

    永田 裕樹, 天野 克比古, 森谷 徳文, 有村 友紀, 中辻 和樹, 加藤 壮真, 飯田 征二

    日本口腔科学会雑誌   72 ( 2 )   77 - 77   2023.7

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  • 頭蓋顔面の発育を制御する頭蓋底軟骨におけるヘッジホッグシグナル受容性の違いと特徴

    天野 克比古, 加藤 壮真, 飯田 征二

    日本顎変形症学会雑誌   33 ( 2 )   223 - 223   2023.5

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  • 開口ゼロスプリントを用いて外科的矯正治療を行なった重度顔面非対称の1例

    中辻 和樹, 天野 克比古, 永田 倭代, 中村 政裕, 有村 友紀, 近藤 星, 永田 裕樹, 加藤 壮真, 上岡 寛, 飯田 征二

    日本顎変形症学会雑誌   33 ( 2 )   219 - 219   2023.5

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  • 骨延長術を用いて上顎骨の形態・位置的改善を行った口唇口蓋裂症例の臨床的検討

    有村 友紀, 天野 克比古, 岡田 亜由美, 兵藤 藍子, 三上 彩可, 岩本 悠希, 飯田 征二

    日本口蓋裂学会雑誌   48 ( 2 )   188 - 188   2023.4

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  • 口腔支持療法により外来放射線治療を完遂できた口腔癌3症例

    武田 斉子, 有村 友紀, 田村 庄平, 中辻 和樹, 三上 彩可, 松崎 秀信, 丸山 貴之, 横井 彩, 天野 克比古, 水川 展吉, 飯田 征二

    日本口腔ケア学会雑誌   17 ( 3 )   242 - 242   2023.4

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  • 濾胞性リンパ腫と鑑別が必要であった上顎歯肉癌頸部リンパ節転移の1例

    天野 克比古, 小橋 寛薫, 笠原 駿, 須河内 昭成, 田中 晋, 大倉 正也, 古郷 幹彦

    日本口腔科学会雑誌   69 ( 2 )   174 - 174   2020.7

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  • 濾胞性リンパ腫と鑑別が必要であった上顎歯肉癌頸部リンパ節転移の1例

    天野 克比古, 小橋 寛薫, 笠原 駿, 須河内 昭成, 田中 晋, 大倉 正也, 古郷 幹彦

    日本口腔科学会雑誌   69 ( 2 )   174 - 174   2020.7

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  • 変形性顎関節炎は性ホルモンと機械的刺激により惹起される

    石井 武展, 大竹 智久, 渡邉 章, 西村 壽晃, 天野 克比古, 長尾 雅史, 西井 康

    日本顎関節学会雑誌   32 ( Suppl. )   84 - 84   2020.7

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  • 変形性顎関節症の軟骨破壊に対する性ホルモンと機械的刺激の作用機序の解明

    石井 武展, 大竹 智久, 崔 大煥, 石川 宗理, 末石 研二, 渡邉 章, 斎藤 力, 石塚 洋一, 天野 克比古, 長尾 雅史, 西村 壽晃, 河井 敬久

    歯科学報   118 ( 4 )   279 - 280   2018.8

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  • 転写因子Arid5bはSox9の転写機能を促進することにより軟骨細胞分化を制御する

    高島 利加子, 波多 賢二, 若林 真, 小野 孝一郎, 天野 克比古, 中西 雅子, 前田 芳信, 西村 理行, 米田 俊之

    日本骨代謝学会学術集会プログラム抄録集   29回   191 - 191   2011.7

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  • 口蓋裂を伴う両側性斜顔面裂の1例

    小橋 寛薫, 山西 整, 宮 成典, 天野 克比古, 岸 直子, 小野 雄大, 古郷 幹彦, 森沢 猛, 米谷 昌彦, 松下 賢治

    日本口蓋裂学会雑誌   36 ( 2 )   129 - 129   2011.4

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  • Sox9の標的転写因子Dmrt2はRunx2を介して内軟骨性骨化の後期分化を制御する

    小野 孝一郎, 波多 賢二, 天野 克比古, 中西 雅子, 西村 理行, 米田 俊之

    日本骨代謝学会学術集会プログラム抄録集   27回   163 - 163   2009.7

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  • 転写制御因子Znf219は、Sox9転写ファクトリーの構成因子として軟骨細胞分化を制御する

    滝川 陽子, 波多 賢二, 村松 周治, 天野 克比古, 小野 孝一郎, 若林 真, 松田 昭生, 西村 理行, 米田 俊之

    日本骨代謝学会学術集会プログラム抄録集   26回   169 - 169   2008.10

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  • Sox9ファミリーはPTHrPの発現誘導を介し内軟骨性骨形成の後期分化を抑制する

    天野 克比古, 波多 賢二, 小野 孝一郎, 古郷 幹彦, 西村 理行, 米田 俊之

    日本骨代謝学会学術集会プログラム抄録集   26回   169 - 169   2008.10

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  • 性分化制御転写因子Dmrt2は内軟骨性骨化を制御する

    小野 孝一郎, 波多 賢二, 杉田 淳, 天野 克比古, 滝川 陽子, 中西 雅子, 西村 理行, 米田 俊之

    日本骨代謝学会学術集会プログラム抄録集   26回   145 - 145   2008.10

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  • 内軟骨性骨化におけるDmrt2の役割の検討

    小野 孝一郎, 波多 賢二, 中村 恵理子, 杉田 淳, 天野 克比古, 滝川 陽子, 中西 雅子, 西村 理行, 竹之下 誠一, 米田 俊之

    日本整形外科学会雑誌   82 ( 8 )   S1188 - S1188   2008.8

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  • 下顎枝矢状分割骨切り術術後の外側骨片位置の経時的変化 Reviewed

    天野 克比古, 飯田 征二, 八木 孝和, 相川 友直, 増田 智丈, 高尾 香名, 古郷 幹彦

    日本口腔科学会雑誌   54 ( 4 )   575 - 575   2005.9

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MISC

  • Gli1陽性細胞特異的Pth1rシグナル欠損マウスは頭蓋底軟骨の発育異常を呈する

    天野克比古, 天野克比古, 相川友直, 相川友直, 宮川和晃, 古郷幹彦, 飯田征二

    日本口腔科学会学術集会プログラム・抄録集   77th   2023

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  • がん化学療法中のインプラント周囲炎予防の意義~周術期口腔機能管理の重要性~

    大西淑美, 平岡慎一郎, 平岡慎一郎, 伊藤加代子, 白石由美, 近藤敬秀, 外川健史, 西野仁, 正元洋介, 石本俊介, 大槻浩一, 天野克比古, 天野克比古, 古郷幹彦, 東山聖彦, 東山聖彦

    日本癌治療学会学術集会(Web)   54th   ROMBUNNO.P26‐4 (WEB ONLY) - 4   2016.10

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  • TGF-B in jaw tumor fluids induces RANKL expression in stromal fibroblasts

    Emi Okuno, Tomonao Aikawa, Kazuaki Miyagawa, Chiaki Yamada, Masaaki Kimata, Katsuhiko Amano, Masaya Okura, Mikihiko Kogo

    ORAL ONCOLOGY   49   S124 - S125   2013.5

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    DOI： 10.1016/j.oraloncology.2013.03.333

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  • Ihh Directly Regulates ColX Expression by PTHrP-independent Mechanisms via Runx2/Smad Interaction during Limb Development

    Katsuhiko Amano, Katsuhiko Amano, Michael Densmore, Riko Nishimura, Toshiyuki Yoneda, Mikihiko Kogo, Beate Lanske

    JOURNAL OF BONE AND MINERAL RESEARCH   28   2013.2

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  • THE TRANSCRIPTION FACTOR ARID5B MODULATES ENDOCHONDRAL BONE FORMATION IN COOPERATION WITH SOX9

    R. Takashima, K. Hata, K. Ono, M. Wakabayashi, K. Amano, M. Nakanishi, Y. Maeda, R. H. Whitson, R. Nishimura, T. Yoneda

    OSTEOPOROSIS INTERNATIONAL   22   S522 - S523   2011.9

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  • Transcription factor Dmrt2 (double-sex and mab-3 related transcription factor 2) controls endochondral ossification by inhibiting early chondrogenesis and promoting late chondrogenesis

    K. Ono, K. Hata, E. Nakamura, A. Sugita, K. Amano, Y. Takigawa, M. Nakanishi, R. Nishimura, T. Yoneda

    BONE   44 ( 2 )   S346 - S346   2009.6

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    DOI： 10.1016/j.bone.2009.03.156

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  • A transcription factor Znf219 regulates chondrogenesis by forming a transcription factory complex with Sox9

    Y. Takigawa, K. Hata, S. Muramatsu, K. Amano, K. Ono, K. Takada, M. Wakabayashi, A. Matsuda, R. Nishimura, T. Yoneda

    BONE   44   S43 - S43   2009.5

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    DOI： 10.1016/j.bone.2009.01.110

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  • Transcription Factor Dmrt2 Controls Endochondral Ossification Through Regulating Type 10 Collagen (Col10a1) Gene Expression

    K. Ono, K. Hata, E. Nakamura, A. Sugita, K. Amano, M. Nakanishi, Y. Takigawa, R. Nishimura, S. Takenoshita, T. Yoneda

    JOURNAL OF BONE AND MINERAL RESEARCH   23   S14 - S14   2008.9

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  • A Transcription Factor Znf219 Regulates Chondrocyte Differentiation Through Forming Transcription Factory Complex with Sox9

    Y. Takigawa, K. Hata, S. Muramatsu, K. Amano, K. Takada, A. Matsuda, R. Nishimura, T. Yoneda

    JOURNAL OF BONE AND MINERAL RESEARCH   23   S74 - S74   2008.9

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  • Msx2 promotes late stages of chondrocyte differentiation by upregulating Ihh expression

    K. Amano, F. Ichida, A. Sugita, K. Hata, M. Kogo, R. Nishimura, T. Yoneda

    JOURNAL OF BONE AND MINERAL RESEARCH   22   S385 - S385   2007.9

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  • An arid family transcription factor Mrf1 regulates chondrocyte differentiation through forming transcription factory with Sox9/5/6.

    K. Amano, K. Hata, S. Muramatsu, A. Matsuda, A. Sugita, M. Kogo, R. Nishimura, T. Yoneda

    JOURNAL OF BONE AND MINERAL RESEARCH   21   S11 - S11   2006.9

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  • 口蓋裂患者の上顎劣成長 予防と対処 口唇口蓋裂症例に対する上顎骨仮骨延長術 Anterior maxillary segmental distractionの応用

    飯田 征二, 相川 友直, 八木 孝和, 高田 健治, 横田 祐介, 天野 克比古, 古郷 幹彦

    日本口腔科学会雑誌   54 ( 1 )   66 - 66   2005.1

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Research Projects

  • Spatiotemporal Analysis of the Proliferation and Differentiation Mechanisms of Gli1-Positive Stem Cells in the Periodontal Ligament During Orthodontic Tooth Movement

    Grant number：25K13278  2025.04 - 2028.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    石井 武展, 天野 克比古, 西村 寿晃, 大野 建州, 溝口 利英

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    Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）

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  • Molecular screening in cranial base cartilage and jaw development

    Grant number：23K09331  2023.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    天野 克比古, 奥崎 大介

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    Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

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  • Single-cell transcriptomics using a mouse model for craniosynostosis

    2023.02 - 2024.03

    公益財団法人中富健康科学振興財団研究助成金 

    Katsuhiko Amano

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  • The role of Pth1r signaling in regulation of craniofacial suture stem cell

    2019.10 - 2020.10

    金原一郎記念医学医療振興財団  基礎医学医療研究助成金 

    Katsuhiko Amano

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    Authorship：Principal investigator 

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  • The study to establish animal models and molecular insight of targeted therapy drugs associated osteonecrosis of the jaw

    Grant number：19K10286  2019.04 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Amano Katsuhiko

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    Grant amount：\4420000 （ Direct expense: \3400000 、 Indirect expense：\1020000 ）

    We aimed to establish an animal model performing tooth extraction in C57BL/6 mice as an experimental model to study osteonecrosis of the jaw associated with molecular target drug. We evaluated the healing after tooth extraction administrating sunitinib malate with or without bisphosphonate. We made these 4 groups; Control, i.p. injection of zoledronic acid, oral intake of sunitinib malate, combined. Significant difference was not observed between 4 groups concerning postoperative epithelization and alveolar bone healing, resulting in the negative data to reproduce human ONJ.

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  • 分子標的治療薬が顎骨壊死に関連する実験モデルと分子機序の確立

    2019.04 - 2023.03

    日本学術振  科学研究費補助金 基盤研究C 

    天野 克比古

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  • The role of Ihh signaling in hyperphosphatemia-induced vascular mineralization

    2018.01 - 2019.04

    上原記念生命科学財団研究奨励金 

    Katsuhiko Amano

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    Authorship：Principal investigator 

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  • The possible non-canonical pathway in hedgehog signaling

    2016.10 - 2019.03

    武田科学振興財団医学系研究奨励（基礎） 

    Katsuhiko Amano

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    Authorship：Principal investigator 

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  • The molecular network in regulation of craniofacial formation

    2016.04 - 2018.03

    日本学術振興会  科学研究費補助金 若手研究（B） 

    Katsuhiko Amano

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    Authorship：Principal investigator 

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  • The role of Ihh signaling in the aging bone

    2013.01 - 2013.12

    上原記念生命科学財団  海外留学助成金（リサーチフェロー） 

    Katsuhiko Amano

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    Authorship：Principal investigator 

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  • The spatiotemporal regulation by Ihh signaling in cartilage metabolism and the disease

    2011.05 - 2012.12

    日本学術振興会  海外特別研究員 

    Katsuhiko Amano

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    Authorship：Principal investigator 

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  • Health and Oral Diseases （2024academic year） Second semester  - 木5～6

  • Clinical training: Oral and Maxillofacial Surgery （2024academic year） special  - その他

  • Lecture and Research Projects: Oral and Maxillofacial Surgery （2024academic year） special  - その他

  • Clinical training: Oral Medicine, and Oral and Maxillofacial Implantology （2024academic year） special  - その他

  • Lecture and Research Projects: Oral Medicine, and Oral and Maxillofacial Implant （2024academic year） special  - その他

  • Salivary glands disease （2024academic year） 1st semester  - 金4

  • Practica A for Clinical Specialties in Dentistry（Oral and Maxillofacial Surgery） （2024academic year） special  - その他

  • Practica A for Clinical Specialties in Dentistry（Oral Medicine, and Oral and Maxillofacial Implant） （2024academic year） special  - その他

  • Practica B for Clinical Specialties in Dentistry（Oral and Maxillofacial Surgery） （2024academic year） special  - その他

  • Practica B for Clinical Specialties in Dentistry（Oral Medicine, and Oral and Maxillofacial Implantology） （2024academic year） special  - その他

  • Management of inflammatory disease （2024academic year） Second semester  - 水5,水6

  • Practicals: Oral and Maxillofacial Reconstructive Surgery （2024academic year） special  - その他

  • Research Projects: Oral and Maxillofacial Reconstructive Surgery （2024academic year） special  - その他

  • Research Projects and Practicals: Oral and Maxillofacial Reconstructive Surgery I （2024academic year） special  - その他

  • Lecture and Research Projects: Oral and Maxillofacial Reconstructive Surgery I （2024academic year） special  - その他

  • Research Projects and Practicals: Oral and Maxillofacial Reconstructive Surgery II （2024academic year） special  - その他

  • Lecture and Research Projects: Oral and Maxillofacial Reconstructive Surgery II （2024academic year） special  - その他

  • Health and Oral Diseases （2023academic year） Second semester  - 木5～6

  • Clinical training: Oral and Maxillofacial Surgery （2023academic year） special  - その他

  • Lecture and Research Projects: Oral and Maxillofacial Surgery （2023academic year） special  - その他

  • Clinical training: Oral Medicine, and Oral and Maxillofacial Implantology （2023academic year） special  - その他

  • Lecture and Research Projects: Oral Medicine, and Oral and Maxillofacial Implant （2023academic year） special  - その他

  • Salivary glands disease （2023academic year） 1st semester  - 金4

  • Practica A for Clinical Specialties in Dentistry（Oral and Maxillofacial Surgery） （2023academic year） special  - その他

  • Practica A for Clinical Specialties in Dentistry（Oral Medicine, and Oral and Maxillofacial Implant） （2023academic year） special  - その他

  • Practica B for Clinical Specialties in Dentistry（Oral and Maxillofacial Surgery） （2023academic year） special  - その他

  • Practica B for Clinical Specialties in Dentistry（Oral Medicine, and Oral and Maxillofacial Implantology） （2023academic year） special  - その他

  • Management of inflammatory disease （2023academic year） Second semester  - 水5,水6

  • Practicals: Oral and Maxillofacial Reconstructive Surgery （2023academic year） special  - その他

  • Research Projects: Oral and Maxillofacial Reconstructive Surgery （2023academic year） special  - その他

  • Research Projects and Practicals: Oral and Maxillofacial Reconstructive Surgery I （2023academic year） special  - その他

  • Lecture and Research Projects: Oral and Maxillofacial Reconstructive Surgery I （2023academic year） special  - その他

  • Research Projects and Practicals: Oral and Maxillofacial Reconstructive Surgery II （2023academic year） special  - その他

  • Lecture and Research Projects: Oral and Maxillofacial Reconstructive Surgery II （2023academic year） special  - その他

  • Management of inflammatory disease （2022academic year） Second semester  - 水5,水6

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