研究者詳細 - 藤原　英晃

論文 - 藤原　英晃

分割表示 84 件中 61 - 80 件目／全件表示 >>

Computational analysis of continuous body temperature provides early discrimination of graft-versus-host disease in mice. 査読国際誌

Blood Advances 3 ( 23 ) 3977 - 3981 2019年12月

miR-142 controls metabolic reprogramming that regulates dendritic cell activation. 査読国際誌

Journal of Clinical Investigation 129 ( 5 ) 2029 - 2042 2019年4月

A Pipeline for Faecal Host DNA Analysis by Absolute Quantification of LINE-1 and Mitochondrial Genomic Elements Using ddPCR. 査読

Scientific reports 2019年4月

Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation. 査読国際誌

Journal of Immunology 201 ( 11 ) 3443 - 3455 2018年12月

SAG/RBX2 E3 Ubiquitin Ligase Differentially Regulates Inflammatory Responses of Myeloid Cell Subsets. 査読国際誌

Frontiers in immunology 9 2882 - 2882 2018年12月

Murine Models of Steroid Refractory Graft-versus-Host Disease. 査読国際誌

Tomomi Toubai, Corinne Rossi, Isao Tawara, Chen Liu, Cynthia Zajac, Katherine Oravecz-Wilson, Daniel Peltier, Yaping Sun, Hideaki Fujiwara, Shin-Rong Wu, Mary Riwes, Israel Henig, Stephanie Kim, Pavan Reddy

Scientific reports 8 ( 1 ) 12475 - 12475 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Corticosteroids are the first line therapy for acute graft-versus-host disease (GVHD). However, the outcome of steroid refractory GVHD (SR-GVHD) is poor due to a lack of effective treatments. The development of therapies for SR-GVHD is limited by an incomplete understanding of its pathophysiology partly because of the absence of clinically relevant animal models of SR-GVHD. Here we addressed the need for a SR-GVHD animal model by developing both MHC matched multiple minor histocompatibility antigens (miHAs) mismatched and MHC mismatched haploidentical murine models of SR-GVHD. We demonstrate that animals can develop SR-GVHD regardless of whether steroids are initiated early or late post allogeneic bone marrow transplantation (allo-BMT). In general, we observed increased GVHD specific histopathological damage of target organs in SR-GVHD animals relative to steroid responsive animals. Interestingly, we found no significant differences in donor T cell characteristics between steroid refractory and responsive animals suggesting that donor T cell independent mechanisms may play more prominent roles in the pathogenesis of SR-GVHD than was considered previously.

DOI： 10.1038/s41598-018-30814-x

PubMed

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IAPs protect host target tissues from graft-versus-host disease in mice. 査読国際誌

Blood advances 1 ( 19 ) 1517 - 1532 2017年8月

Siglec-G represses DAMP-mediated effects on T cells. 査読国際誌

JCI insight 2 ( 14 ) 2017年7月

A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation. 査読国際誌

Cell reports 19 ( 13 ) 2645 - 2656 2017年6月

SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses. 査読国際誌

American journal of pathology 186 ( 10 ) 2679 - 91 2016年10月

Treatment of thrombotic microangiopathy after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin. 査読国際誌

Transfusion 56 ( 4 ) 886 - 92 2016年4月

Vigorous inflammatory responses in noninfectious pulmonary complication induced by donor lymphocyte infusion. 査読国際誌

Transfusion 56 ( 1 ) 231 - 6 2016年1月

末梢血幹細胞採取時の健常人ドナーにおけるクエン酸中毒発現、電解質異常についての解析

藤井敬子, 石川立則, 吉岡尚徳, 廻勇輔, 藤原英晃, 小林優人, 高木尚江, 閘結稀, 池田亮, 浅野尚美, 小郷博昭, 藤井伸治, 大塚文男

日本輸血細胞治療学会誌 61 ( 6 ) 593 - 593 2015年12月

Intravascular lymphomaの肺病変に関する検討

二宮貴一朗, 藤原英晃, 前田嘉信, 高田尚良, 吉野正, 木浦勝行, 谷本光音

日本リンパ網内系学会会誌 55 100 - 100 2015年6月

Contribution of the PD-1-PD-L Pathway to Chronic Graft-Versus-Host Disease. 査読

Fujiwara H, Kobayashi K, Nishimori H, Nishinohara M, Okamoto S, Matsuoka K, Kondo E, Fujii N, Shinagawa K, Tanimoto M, Maeda Y.

Biology of Blood and Marrow Transplantation. 19 ( 2 ) S324 - S325 2013年4月

CD5陽性限局期び漫性大細胞型リンパ腫の特徴と治療成績. 査読

藤原英晃, 前田嘉信, 山根弘路, 海野正俊, 矢野朋文, 増成太郎, 朝倉昇司, 品川克至, 谷本光音.

日本内科学会雑誌. 102 ( Suppl. ) 186 - 186 2013年4月

High frequency of neurolymphomatosis as a relapse disease of intravascular large B-cell lymphoma. 査読国際誌

Cancer 117 ( 19 ) 4512 - 21 2011年10月

The utility of positron emission tomography/computed tomography in the staging of extranodal natural killer/T-cell lymphoma. 査読国際誌

European journal of haematology 87 ( 2 ) 123 - 9 2011年8月

Random skin biopsy and bone marrow biopsy for diagnosis of intravascular large B cell lymphoma. 査読

MATSUE K

Annals of Hematology 90 417 - 421 2011年4月

Reactivation of hepatitis B virus after rituximab-containing treatment in patients with CD20-positive B-cell lymphoma. 査読国際誌

Cancer 116 ( 20 ) 4769 - 76 2010年10月

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