研究者詳細 - 森田　瑞樹

論文 - 森田　瑞樹

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Impact of Sensor-Axis Combinations on Machine Learning Accuracy for Human Activity Recognition Using Accelerometer Data in Clinical Settings 査読国際誌

Takahiro Yamane, Moeka Kimura, Mizuki Morita

Physical Activity and Health 9 ( 1 ) 95 - 109 2025年5月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ubiquity Press, Ltd.

Background: Identifying patient activity during symptom onset is crucial in conditions such as chronic obstructive pulmonary disease (COPD) or arrhythmia. Accelerometer data can aid in this process; however, minimal data requirements are preferable. This study aimed to determine the minimum number of axes required to accurately recognize activities related to COPD or arrhythmia.Methods: Thirty healthy participants wore a 9-axis accelerometer in five positions and performed nine activities. Machine learning-based activity recognition was conducted using 9-, 6-, and 3-axis data from the nondominant wrist or chest, as these two positions demonstrated high recognition accuracy in our previous study.Results: For the nondominant wrist, the accuracy of recognizing activities such as lying in the supine position, standing, eating, and running was comparable for the 3-axis acceleration and 9-axis data. For the chest, the accuracy of recognizing activities such as lying in the supine position, standing, sitting, using the restroom, and ascending or descending stairs was comparable for 6-axis (combined acceleration and magnetometer) and 9-axis data.Conclusions: The findings suggest that 3-axis acceleration data for the nondominant wrist and 6-axis combined acceleration and magnetometer data for the chest lead to high activity recognition accuracy.

DOI： 10.5334/paah.441

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Clinical-level screening of sleep apnea syndrome with single-lead ECG alone is achievable using machine learning with appropriate time windows 査読国際誌

Takahiro Yamane, Masanori Fujii, Mizuki Morita

Sleep and Breathing 29 ( 2 ) 156 2025年4月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Purpose: To establish a simple and noninvasive screening test for sleep apnea (SA) that imposes less burden on potential patients. The specific objective of this study was to verify the effectiveness of past and future single-lead electrocardiogram (ECG) data from SA occurrence sites in improving the estimation accuracy of SA and sleep apnea syndrome (SAS) using machine learning.
Methods: The Apnea-ECG dataset comprising 70 ECG recordings was used to construct various machine-learning models. The time window size was adjusted based on the accuracy of SA detection, and the performance of SA detection and SAS diagnosis (apnea‒hypopnea index ≥ 5 was considered SAS) was compared.
Results: Using ECG data from a few minutes before and after the occurrence of SAs improved the estimation accuracy of SA and SAS in all machine learning models. The optimal range of the time window and achieved accuracy for SAS varied by model; however, the sensitivity ranged from 95.7 to 100%, and the specificity ranged from 91.7 to 100%.
Conclusions: ECG data from a few minutes before and after SA occurrence were effective in SA detection and SAS diagnosis, confirming that SA is a continuous phenomenon and that SA affects heart function over a few minutes before and after SA occurrence. Screening tests for SAS, using data obtained from single-lead ECGs with appropriate past and future time windows, should be performed with clinical-level accuracy.

DOI： 10.1007/s11325-025-03316-0

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その他リンク： https://link.springer.com/article/10.1007/s11325-025-03316-0/fulltext.html

Application of Nine-Axis Accelerometer-Based Recognition of Daily Activities in Clinical Examination 査読国際誌

Takahiro Yamane, Moeka Kimura, Mizuki Morita

Physical Activity and Health 8 ( 1 ) 29 - 46 2024年3月

Tri-Axial Accelerometer-Based Recognition of Daily Activities Causing Shortness of Breath in COPD Patients 査読国際誌

Takahiro Yamane, Yuu Yamasaki, Wakana Nakashima, Mizuki Morita

Physical Activity and Health 7 ( 1 ) 64 - 75 2023年2月

Trial of sportswear type ECG sensor device for cardiac safety management during marathon running 査読国際誌

Takahiro Yamane, Kazuya Hirano, Kenta Hirai, Daiki Ousaka, Noriko Sakano, Mizuki Morita, Susumu Oozawa, Shingo Kasahara

Advanced Biomedical Engineering 11 151 - 161 2022年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society for Medical and Biological Engineering (JSMBE)

Cardiac arrest has been reported during participation in several sports. Of these sports, marathon running is a particularly popular sport but imposes high cardiac load. Indeed, its popularity has been growing worldwide. Risk of cardiac arrest during marathon races is also expected to increase. Several studies have recorded electrocardiographic (ECG) information during marathon races to protect athletes from cardiac arrest. Although evaluable ECG data have been obtained and analyzed, cost-effectiveness of the system, data quality, and clinical significance remain inadequate. This report is the first to describe an economical electrocardiograph built into a T-shirt for use during marathon race. Twenty healthy runners aged 20 to 59 years (mean 36 years) wore the ECG device while running. The ECG data were monitored and analyzed to assess the observed frequencies of specified arrhythmias and the sections of the marathon in which the arrhythmias occurred. Of the ECG data obtained from 14 runners who completed the full marathon, six ECG datasets were evaluable. In some runners, there was inadequate contact between the electrode and body surface or poor Bluetooth connection between the ECG wireless transmitter and smartphone. Regarding arrhythmia analysis, all evaluable data that were analyzed showed some rhythm fluctuations. In conclusion, this economical T-shirt type ECG sensor provided evaluable ECG data during marathon races, although the evaluable rate was not high. The data were used to analyze specified arrhythmias, but some difficulties were encountered. The ECG sensor did not function properly because of a system error. The ECG sensor was not adequately moistened to record ECGs accurately. Moreover, some runners chose an unsuitable shirt size, which impaired the stability and strength of the electrode–skin contact. These shortcomings produced noise in the ECG data, which made it difficult to analyze arrhythmias. The next step will be to solve these problems and acquire data from a large number of runners.

DOI： 10.14326/abe.11.151

Web of Science

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Initial evaluation of a novel electrocardiography sensor-embedded fabric wear during a full marathon 査読国際誌

Daiki Ousaka, Kenta Hirai, Noriko Sakano, Mizuki Morita, Madoka Haruna, Kazuya Hirano, Takahiro Yamane, Akira Teraoka, Kazuo Sanou, Susumu Oozawa, Shingo Kasahara

Heart and Vessels 37 ( 3 ) 443 - 450 2022年3月

Multiple cancer type classification by small RNA expression profiles with plasma samples from multiple facilities 査読国際誌

Kuno Suzuki, Hideyoshi Igata, Motoki Abe, Yusuke Yamamoto, small RNA based cancer classification project

Cancer Science 113 ( 6 ) 2144 - 2166 2022年2月

Predicting Anesthetic Infusion Events Using Machine Learning 査読国際誌

Naoki Miyaguchi, Koh Takeuchi, Hisashi Kashima, Mizuki Morita, Hiroshi Morimatsu

Scientific Reports 11 ( 1 ) 23648 - 23648 2021年11月

The Data Use Ontology to streamline responsible access to human biomedical datasets 査読国際共著国際誌

Jonathan Lawson, Moran N. Cabili, Giselle Kerry, Tiffany Boughtwood, Adrian Thorogood, Pinar Alper, Sarion R. Bowers, Rebecca R. Boyles, Anthony J. Brookes, Matthew Brush, Tony Burdett, Hayley Clissold, Stacey Donnelly, Stephanie O.M. Dyke, Mallory A. Freeberg, Melissa A. Haendel, Chihiro Hata, Petr Holub, Francis Jeanson, Aina Jene, Minae Kawashima, Shuichi Kawashima, Melissa Konopko, Irene Kyomugisha, Haoyuan Li, Mikael Linden, Laura Lyman Rodriguez, Mizuki Morita, Nicola Mulder, Jean Muller, Satoshi Nagaie, Jamal Nasir, Soichi Ogishima, Vivian Ota Wang, Laura D. Paglione, Ravi N. Pandya, Helen Parkinson, Anthony A. Philippakis, Fabian Prasser, Jordi Rambla, Kathy Reinold, Gregory A. Rushton, Andrea Saltzman, Gary Saunders, Heidi J. Sofia, John D. Spalding, Morris A. Swertz, Ilia Tulchinsky, Esther J. van Enckevort, Susheel Varma, Craig Voisin, Natsuko Yamamoto, Chisato Yamasaki, Lyndon Zass, Jaime M. Guidry Auvil, Tommi H. Nyrönen, Mélanie Courtot

Cell Genomics 1 ( 2 ) 100028 - 100028 2021年11月

Simple Wearable Device to Reduce Stress When Delivering a Speech without Pre-Training 査読国際誌

Takahiro Yamane, Yuma Nakadoi, Mina Takagi, Mizuki Morita

Healthcare Informatics Research 27 ( 3 ) 231 - 240 2021年7月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Korean Society of Medical Informatics

DOI： 10.4258/hir.2021.27.3.231

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その他リンク： https://www.webofscience.com/wos/woscc/full-record/WOS:000684600200008

パンデミックへの備えとしての医療資材の循環備蓄：モデル化とシミュレーション査読

森田瑞樹

統合科学 1 17 - 20 2021年3月

担当区分：筆頭著者,　最終著者,　責任著者記述言語：日本語掲載種別：研究論文（大学，研究機関等紀要）

感染症の世界的な大流行（パンデミック）が発生すると，マスク，消毒液，個人保護具などの医療資材の需要が平時の生産能力を超えるため，必要量を確保することが一時的に困難になる。このような事態に備えるためには備蓄が必要となる。しかし，パンデミックは発生頻度が低く，いつ発生するか予測できないため，パンデミックの際に備蓄した医療資材が古くなっている可能性がある。本稿では，備蓄した医療資材が消費期限を過ぎることを防ぐ工夫として「循環備蓄（ローリングストック）」を提案し，循環備蓄のモデル化とそれに基づいたシミュレーションを示す。これを，循環備蓄用の倉庫の設計，感染症の流行開始における医療資材の減少のモニタリング，医療資材の生産能力が増強された後の備蓄量の回復過程のモニタリングに適用する例を示す。

DOI： 10.18926/interdisciplinary/61886

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遠隔での見守りのための機器・サービスの調査と訪問看護での利用を想定した分類査読

坂本年生, 平田晶奈, 森田瑞樹

統合科学 1 47 - 63 2021年3月

De-identifying free text of Japanese electronic health records 査読国際誌

Kohei Kajiyama, Hiromasa Horiguchi, Takashi Okumura, Mizuki Morita, Yoshinobu Kano

Journal of Biomedical Semantics 11 ( 1 ) 11 - 11 2020年9月

DV200 index for assessing RNA integrity in next-generation sequencing 査読国際誌

Takehiro Matsubara, Junichi Soh, Mizuki Morita, Takahiro Uwabo, Shuta Tomida, Toshiyoshi Fujiwara, Susumu Kanazawa, Shinichi Toyooka, Akira Hirasawa

BioMed Research International 2020 9349132 2020年2月

Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database 査読国際誌

Yoshito Zamami, Takahiro Niimura, Toshihiro Koyama, Yuta Shigemi, Yuki Izawa-Ishizawa, Mizuki Morita, Ayako Ohshima, Keisaku Harada, Toru Imai, Hiromi Hagiwara, Naoto Okada, Mitsuhiro Goda, Kenshi Takechi, Masayuki Chuma, Yutaka Kondo, Koichiro Tsuchiya, Shiro Hinotsu, Mitsunobu R Kano, Keisuke Ishizawa

Frontiers in pharmacology 10 1257 - 1257 2019年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

The survival rate of cardiac arrest patients is less than 10%; therefore, development of a therapeutic strategy that improves their prognosis is necessary. Herein, we searched data collected from medical facilities throughout Japan for drugs that improve the survival rate of cardiac arrest patients. Candidate drugs, which could improve the prognosis of cardiac arrest patients, were extracted using "TargetMine," a drug discovery tool. We investigated whether the candidate drugs were among the drugs administered within 1 month after cardiac arrest in data of cardiac arrest cases obtained from the Japan Medical Data Center. Logistic regression analysis was performed, with the explanatory variables being the presence or absence of the administration of those candidate drugs that were administered to ≥10 patients and the objective variable being the "survival discharge." Adjusted odds ratios for survival discharge were calculated using propensity scores for drugs that significantly improved the proportion of survival discharge; the influence of covariates, such as patient background, medical history, and treatment factors, was excluded by the inverse probability-of-treatment weighted method. Using the search strategy, we extracted 165 drugs with vasodilator activity as candidate drugs. Drugs not approved in Japan, oral medicines, and external medicines were excluded. Then, we investigated whether the candidate drugs were administered to the 2,227 cardiac arrest patients included in this study. The results of the logistic regression analysis showed that three (isosorbide dinitrate, nitroglycerin, and nicardipine) of seven drugs that were administered to ≥10 patients showed significant association with improvement in the proportion of survival discharge. Further analyses using propensity scores revealed that the adjusted odds ratios for survival discharge for patients administered isosorbide dinitrate, nitroglycerin, and nicardipine were 3.35, 5.44, and 4.58, respectively. Thus, it can be suggested that isosorbide dinitrate, nitroglycerin, and nicardipine could be novel therapeutic agents for improving the prognosis of cardiac arrest patients.

DOI： 10.3389/fphar.2019.01257

PubMed

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Challenges in Building and Maintaining Rare Disease Patient Registries: Results of a Questionnaire Survey in Japan at 2012

Mizuki Morita, Soichi Ogishima

medRxiv 19004770 2019年8月

A new approach to prevent critical cardiac accidents in athletes by real-time electrocardiographic tele-monitoring system: Initial trial in full marathon 査読国際誌

Daiki Ousaka, Noriko Sakano, Mizuki Morita, Takayuki Shuku, Kazuo Sanou, Shingo Kasahara, Susumu Oozawa

Journal of Cardiology Cases 20 ( 1 ) 35 - 38 2019年5月

Tweet Classification Toward Twitter-Based Disease Surveillance: New Data, Methods, and Evaluations 査読国際誌

Shoko Wakamiya, Mizuki Morita, Yoshinobu Kano, Tomoko Ohkuma, Eiji Aramaki

Journal of Medical Internet Research 21 ( 2 ) e12783 2019年2月

Change Detection in Vital Signs Associated with Impending Death for Homecare Patients Using a Pressure-Sensing Mat 査読国際誌

Takayuki Shuku, Noriko Sakano, Mizuki Morita, Shingo Kasahara

European Journal for Biomedical Informatics 14 ( 1 ) 52 - 57 2018年2月

Medical Attitudes Survey for Female Dystrophinopathy Carriers in Japan 査読国際誌

Michio Kobayashi, Tomoyuki Hatakeyama, Masatoshi Ishizaki, Katsuhito Adachi, Mizuki Morita, Naohiro Yonemoto, Tsuyoshi Matsumura, Itaru Toyoshima, En Kimura

Internal Medicine 57 ( 16 ) 2325 - 2332 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

Objective This study attempted to clarify the current status of female dystrophinopathy carriers, including the numbers of patients, the status of genetic screening, the status of counseling. physicians' understanding. and barriers to registration.Methods We sent out questionnaires to 402 physicians registered in the Remudy dystrophinopathy registry. The total number of responses received was 130 (response rate: 32%).Result In total, 1,212 cases of Duchenne muscular dystrophy, 365 cases of Becker muscular dystrophy, and 132 cases of female dystrophinopathy with a confirmed genetic mutation were encountered, and genetic testing was performed in the mother in 137, 23, and 12 cases, respectively. With respect to the risk of the onset of health problems, 25% of physicians always explained, 29% usually explained, 29% sometimes explained, and 13% never explained the risk to the mothers and female siblings of dystrophinopathy patients. The most common reason for not explaining the risk was a lack of knowledge/information. Thirty-five percent were familiar with the guidelines for testing the heart function of carriers.Conclusion Fewer mothers of dystrophinopathy patients have undergone genetic testing in Japan than in other countries. A significant portion of doctors did not explain the risks of health problems due to a lack of knowledge. We hope this survey will lead to an increased discussion of female dystrophinopathy patients.

添付ファイル： advpub_0163-17.pdf

DOI： 10.2169/internalmedicine.0163-17

Web of Science

PubMed

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