記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2174/18742106-v16-2202140

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVES: To examine the diagnostic usefulness and procedures of ultrasonography (US) for mass lesions in the soft tissue of the oral region. METHODS: This study involved patients with mass lesions (tumorous lesions and cysts) who had undergone US and histopathological examinations from January 2017 to December 2019. The following points were evaluated by two observers using an evaluation scale: vascularity, echo intensity level, boundary, margin shape, distribution of internal echoes, and capsule. The usefulness of each point for differential diagnosis of tumorous lesions and cysts was statistically analyzed. RESULTS: Forty-five mass lesions in the soft tissue of the oral region (33 tumorous lesions and 12 cysts) were analyzed. There were significant differences in four evaluation points between the tumorous lesions and cysts: vascularity, echo intensity level, boundary, and margin shape. Cysts were almost completely excluded diagnostically, especially when vascularity was observed. There were also significant differences in two evaluation points between nonvascular tumorous lesions and cysts: echo intensity level and boundary. CONCLUSIONS: In US examination for mass lesions in the oral region, it was possible to diagnose tumorous lesions and exclude cysts when vascularity was observed. When vascularity was not observed, however, tumorous lesions and cysts could be identified using two evaluation points: echo intensity level and boundary.

DOI： 10.1007/s11282-022-00605-2

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11282-022-00605-2

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.5624/isd.20210218

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Purpose: To focus on the effects of the presence of mesiodens on adjacent teeth and to investigate the timing of its safe removal. Materials and Methods: Cone-beam computed tomography examinations, obtained at Okayama University Hospital over a three-year period, were inspected. Data were recorded including the number of mesiodens; associated abnormalities; and the relationship with neighboring structures. Depending on multiple factors, the risk of developing complications due to early extraction of a mesiodens was divided into three categories: high, medium, and low risk. Results: A total of 5,958 cone-beam computed tomography exams were obtained, 460 patients aged 3-85 years were diagnosed with a total of 568 mesiodens, 382 (67.3%) of which were discovered in young patients (age <10 years), and 333 (87.2%) of these were associated with abnormalities. Regarding the risk categories, 11 (1.9%) were considered to be in the high-risk, five (0.9%) in the medium-risk and 552 (97.2%) in the low-risk categories. Moreover, eight out of 11 high-risk mesiodens were extracted and no post-operative complications have been seen. Conclusion: As the results showed that no postoperative complications were seen in all the extracted cases of high-risk mesiodens, this indicates the possibility of safe extraction at an early age which could reduce related future complications.

DOI： 10.5624/isd.20210218

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18926/AMO/63205

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The apparent diffusion coefficient subtraction method (ASM) was developed as a new restricted diffusionweighted imaging technique for magnetic resonance imaging (MRI). The usefulness of the ASM has been established by in vitro basic research using a bio-phantom, and clinical research on the application of the ASM for the human body is needed. Herein, we developed a short-time sequence for ASM imaging of the heads of healthy volunteers (n=2), and we investigated the similarity between the obtained ASM images and diffusion kurtosis (DK) images to determine the utility of the ASM for clinical uses. This study appears to be the first to report ASM images of the human head. We observed that the short-time sequence for the ASM imaging of the head can be scanned in approx. 3 min at 1.5T MRI. The noise reduction effect of median filter processing was confirmed on the ASM images scanned by this sequence. The obtained ASM images showed a weak correlation with the DK images, indicating that the ASM images are restricted diffusion-weighted images. The new shorttime imaging sequence could thus be used in clinical studies applying the ASM.

DOI： 10.18926/AMO/63205

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BENTHAM SCIENCE PUBL LTD  

Background:An odontogenic myxoma is an intraosseous tumor characterized by stellate and spindle-shaped cells embedded in an abundant myxoid or mucoid extracellular matrix. We herein describe an odontogenic myxoma that expanded not only to the bone marrow but also to the outside of the alveolar bone. Diagnosis of an odontogenic myxoma in a tooth-deficient region by imaging findings alone was difficult because the positional relationship between the tumor and the tooth is unknown. Furthermore, some of these odontogenic myxomas reportedly show rapid growth.Case Report:Here, we present the case of a patient, a 44-year-old man, who had a hard, bone-like swelling on his right mandible molar region and mild paresthesia on his right cheek. An odontogenic myxoma and ameloblastoma were suspected based on the imaging findings; however, pathological examination of the biopsy led to a diagnosis of odontogenic myxoma. Right segmental mandibulectomy was performed, and there was no recurrence observed after surgery.Conclusion:To improve the accuracy of imaging diagnosis, it is important to compare the imaging findings with the pathological findings of the surgical specimen. This comparison in the present case revealed differences in the magnetic resonance imaging signal intensity in regions with different types of cell components.

DOI： 10.2174/18742106-v16-2202140

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3892/ol.2021.13039.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/ca.23779.

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPANDIDOS PUBL LTD  

Immune checkpoint inhibitors (ICIs) targeting programmed death ligand-1 (PD-L1) are highly promising therapies for oral squamous cell carcinoma (OSCC). The assessment of PD-L1 expression may help predicting the therapeutic effect of ICIs and, thus, benefit patient selection. Contrast index (CI) parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) have been proven as efficient to assess microvessel density (MVD) in OSCC. The present study aimed to determine the correlation between DCE-MRI parameters and MVD and between DCE-MRI parameters and PD-L1 expression to determine whether DCE-MRI could be used non-invasively to evaluate PD-L1 expression in patients with OSCC. A total of 21 patients with primary OSCC who had undergone a 3T MRI scan, including DCE-MRI, were included in the present study, and CI curve-derived parameters were examined. The MVD and PD-L1 expression in the surgically resected specimens were analyzed using immunohistochemistry (IHC) staining for CD31 and IHC staining for PD-L1, respectively. The results demonstrated that the expression levels of these markers were correlated with DCE-MRI parameters. PD-L1 expression levels were found to be significantly correlated with the maximum CI (CI-max; P=0.007), peak CI (CI-peak; P=0.007), maximum CI gain (CI-gain; P=0.006) and MVD (P=0.001) values. The mean CI-max, CI-peak, CI-gain and MVD values were significantly higher in tumors with high PD-L1 expression (P<0.05). MVD levels were also significantly correlated with the time of CI-max (T-max; P=0.003) and CI-gain (P=0.037). The mean CI-gain was significantly increased, and the mean T-max was significantly shorter in high MVD tumors (P<0.05 and P<0.01, respectively). In summary, the findings from the present study confirmed the correlation between CI parameters, derived from DCE-MRI, and MVD, and suggested that these parameters may be correlated with PD-L1 expression in OSCC tumor cells.

DOI： 10.3892/ol.2021.13039

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/ca.23740.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The usefulness of the field-in-field with two reference points (FIF w/ 2RP) method, in which the dose reference points are set simultaneously at two positions in the irradiation field and the high-dose range is completely eliminated, was examined in the present study with the aim of decreasing acute skin toxicity in adjuvant breast radiotherapy (RT). A total of 573 patients with breast cancer who underwent postoperative whole breast RT were classified into 178 cases with wedge (W) method, 142 cases with field-in-field without 2 reference points (FIF w/o 2RP) method and 253 cases with FIF w/ 2RP method. Using the FIF w/ 2RP method, the high-dose range was the lowest among the three irradiation methods. The planning target volume (PTV) V105% and the breast PTV for evaluation (BPe) V105% decreased to 0.09 and 0.10%, respectively. The FIF w/ 2RP method vs. the FIF w/o 2RP method had a strong association (η) with PTV V105% (η=0.79; P<0.001) and BPe V105% (η=0.76; P<0.001). The FIF w/ 2RP method had a significant impact on lowering the skin toxicity grade in weeks 3 and 4, and increasing the occurrence of skin toxicity grade 0. The FIF w/ 2RP method vs. the W method had a moderate association with skin toxicity grade at week 3 (η=0.49; P<0.001). Using the FIF w/ 2RP method, the high-dose range V105% of the target decreased to 0%, and skin adverse events were decreased in conjunction. For patients with early-stage breast cancer, particularly patients with relatively small-sized breasts, the FIF w/ 2RP method may be an optimal irradiation method.

DOI： 10.3892/mco.2021.2355

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The purpose of this study was to evaluate the risk of injury to the facial (FA) and related arteries during mandibular third molar (MTM) extraction using contrast-enhanced computed tomography (CE-CT). CE-CT images of the MTM region were retrospectively reviewed. The area of the MTM was equally divided into three zones in the coronal images from mesial to distal, that is, zone 1, zone 2, and zone 3. The FA, submental artery (SMA), and sublingual artery (SLA) were identified. The distance from the mandible to FA, SMA, and SLA and the diameter of the FA, SMA, and SLA was measured in three zones, respectively. The thickness of the facial soft tissues and width of the mandible were measured at their maximum. The mean distance from the FA to the buccal cortical bone in zone 1, zone 2 and zone 3 was 2.24 mm, 2.39 mm and 1.67 mm, respectively. The SMA and SLA were found to be distal to the mandible. The mean diameter of the FA was 1.26 mm in males and 1.04 mm in females, respectively (p < 0.0001). The distance between the FA and buccal cortical bone of the mandible, and the patients' weight showed moderate correlation in zones 1 and 2. Based on our findings, the FA can be damaged if the surgical invasion reaches the facial soft tissues during MTM surgery. The patients' weight might be a good predictor for FA injury when CE-CT is not available.

DOI： 10.1002/ca.23779

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1259/dmfr.20200188.

担当区分：最終著者   記述言語：日本語  

記述言語：日本語   出版者・発行元：(公社)日本歯科医師会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(公社)日本歯科医師会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Reports on irradiation dose distribution in breast cancer radiotherapy with sufficient sample size are limited in Asian patients. Elucidating dose distribution in Asian patients is particularly important as their breast volume differs compared to patients in Europe and North America. Here, we examined dose distribution in the irradiation field relative to breast volume for three irradiation methods historically used in our facility. We investigated the influence of breast volume on each irradiation method for Asian women. A total of 573 women with early-stage breast cancer were treated with breast-conserving surgery and adjuvant radiotherapy. Three methods were compared: wedge (W), field-in-field (FIF), and wedge-field-in-field (W-FIF). In patients with small breast volume, FIF decreased low- and high-dose areas within the planning target volume, and increased optimal dose area more than W. In patients with medium and large breast volumes, FIF decreased high-dose area more than W. The absolute values of correlation coefficients of breast volume to low-, optimal-, and high-dose areas and mean dose were significantly lower in FIF than in W. The correlation coefficients of V107% were 0.00 and 0.28 for FIF and W, respectively. FIF is an excellent irradiation method that is less affected by breast volume than W in Asian breast cancer patients.

DOI： 10.18926/AMO/62225

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The general principles of anatomical terminology indicate that the "mandibular canal" should be named the "inferior alveolar canal" as it accommodates the inferior alveolar neurovascular bundles. Therefore, we performed a Delphi study to evaluate the current understanding and use of the terminology in different geographical regions and areas of expertise and to determine the appropriate terminology for this bony canal. A Delphi panel was formed and questions sent and answered via email about: field of expertise (anatomy, oral surgery/oral and maxillofacial (OMF) surgery, oral radiology/OMF radiology, plastic surgery, ENT surgery, or dentistry with the exception of oral/OMF surgery and oral/OMF radiology), years of experience in the field of expertise, country currently working in, "what is the name of the bony canal that contains the inferior alveolar neurovascular bundle," and "what should the structure above be called, in general?" A total of 52 participants responded to the questionnaire. Half or more of the experts in anatomy, oral/OMF surgery, and ENT/plastic surgery considered "mandibular canal" to be the most appropriate name for this bony canal. In contrast, more than half of all experts in oral/OMF radiology and dentistry, that is, most fields of dentistry, considered "either mandibular canal or inferior alveolar canal" to be the appropriate name. The results of the Delphi study and general principles suggest that an alternative term for the "mandibular canal" should be "inferior alveolar canal."

DOI： 10.1002/ca.23740

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Diffusion-weighted imaging may be used to obtain the apparent diffusion coefficient (ADC), which aids the diagnosis of cerebral infarction and tumors. An ADC reflects elements of free diffusion. Diffusion kurtosis imaging (DKI) has attracted attention as a restricted diffusion imaging technique. The ADC subtraction method (ASM) was developed to visualize restricted diffusion with high resolution by using two ADC maps taken with different diffusion times. We conducted the present study to provide a bridge between the reported basic ASM research and clinical research. We developed new imaging software for clinical use and evaluated its performance herein. This software performs the imaging process automatically and continuously at the pixel level, using ImageJ software. The new software uses a macro or a plugin which is compatible with various operating systems via a Java Virtual Machine. We tested the new imaging software's performance by using a Jurkat cell bio-phantom, and the statistical evaluation of the performance clarified that the ASM values of 99.98% of the pixels in the bio-phantom and physiological saline were calculated accurately (p<0.001). The new software may serve as a useful tool for future clinical applications and restricted diffusion imaging research.

DOI： 10.18926/AMO/61880

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記述言語：日本語   出版者・発行元：日本口腔顎顔面技工学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔ケア学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔ケア学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.5624/isd.20200253

記述言語：日本語   出版者・発行元：(一社)日本病理学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVES: The purpose of this study was to evaluate the usefulness of Hounsfield unit (HU) assessment with multislice-CT in the differentiation of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs). METHODS: In total, 307 odontogenic cysts (RCs, DCs and OKCs) were included in this study. Cysts with lesion diameter <10 mm, cysts with artefacts affecting measurement of HU values, cysts involving infection and recurrent cysts were regarded as exclusion criteria. Images were acquired in three different types of CT scanners: Aquilion ONE, Discovery CT750 HD and SOMATOM Definition Flash. Differences in HU values among scanners and among types of odontogenic cysts were assessed using one-way analysis of variance; multiple comparisons were performed post hoc, using the Tukey-Kramer honestly significant difference test. RESULTS: In total, 164 cysts were analysed in this study (64 RCs, 57 DCs and 43 OKCs). Regardless of the type of lesion, the Aquilion ONE scanner demonstrated a significant difference in HU value, compared with the Discovery CT750 HD scanner. Regardless of CT scanner model, HU values significantly differed between DCs and OKCs (p < 0.0001), as well as between OKCs and RCs (p < 0.0001). CONCLUSIONS: HU values were found to vary among CT scanners and should always be associated with other lesion imaging features while interpreting and elaboration diagnostic hypothesis. Notably, the results suggested that OKCs might be able to be differentiated from DCs and RCs by using HU values.

DOI： 10.1259/dmfr.20200188

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18926/AMO/61880.

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.11242/dentalradiology.61.12

掲載種別：研究論文（学術雑誌）   出版者・発行元：Korean Academy of Oral and Maxillofacial Radiology  

DOI： 10.5624/isd.20200253

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その他リンク： https://isdent.org/DOIx.php?id=10.5624/isd.20200253

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3892/br.2020.1359

記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3892/ol.2020.11298

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPANDIDOS PUBL LTD  

The numbers of abnormal findings incidentally detected in adjacent regions are increasing with advances in imaging modalities. The present study aimed to examine the prevalence and characteristics of incidental findings in the thyroid gland on computed tomography (CT) images of the oral and maxillofacial region. CT scans of the oral and maxillofacial region in patients obtained between January 2012 and December 2016 were retrospectively reviewed. Images that revealed incidental findings in the thyroid gland, including nodules, were recorded, together with the sizes and characteristics of the findings. The Japan Association of Breast and Thyroid Sonology (JABTS) guidelines were used for classification. The rate of descriptions of these findings in the radiographic interpretation reports were also examined. Of the 1,135 patients examined, 326 (28.7%) had several types of incidental findings. In particular, 169 (14.9%) of the 1,135 patients had nodules >5 mm in diameter, for which further careful examination is recommended in the JABTS guideline. The description rate for nodules >5 mm in diameter in the radiographic interpretation reports was 30.8% (52/169 patients), of whom 17.3% (9/52 patients) were referred to the endocrinology department for further careful examination. Incidental findings in the thyroid gland were relatively common on CT images of the oral and maxillofacial region. Oral radiologists tend to focus specifically on the oral and maxillofacial region during diagnosis on oral and maxillofacial CT images, but should pay the same careful attention to observe adjacent regions, such as the thyroid gland.

DOI： 10.3892/ol.2020.11298

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s10266-019-00443-5

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.5981/jjhnc.46.264

記述言語：日本語   出版者・発行元：日本頭頸部癌学会  

頭頸部癌に対する放射線治療を受けた患者の体重減少の予測因子について，後方視的に検討を行った。2016年1月〜2018年12月までに初回治療として根治的強度変調放射線治療を受けた43例を対象とした。全例化学療法が併用されていた。38例で5％以上の体重減少を，15例で10％以上の体重減少を認めた。10％以上の体重減少に関する単変量解析では，年齢，頸部リンパ節転移の存在，肉眼的腫瘍体積の大きさ，予防域を含めた全ての計画標的体積の大きさ，口腔の最大線量，歯の状態（上顎および/あるいは下顎が無歯顎）が有意な因子であった。性別，BMI，PS，原発部位，T因子，糖尿病，胃瘻造設，口腔の平均線量は有意な因子ではなかった。多変量解析では，年齢，歯の状態が有意な因子であった。これらの結果から，強度変調放射線治療を受ける頭頸部癌患者では，若年者，有歯顎者であることが10％以上の体重減少の予測因子であることが示唆された。

DOI： 10.5981/jjhnc.46.264

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記述言語：日本語   出版者・発行元：日本口腔顎顔面技工学会  

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11282-018-0359-3.

DOI： 10.1007/s11282-018-0359-3

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3892/mmr.2019.10523.

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語   出版者・発行元：岡山歯学会  

歯学部学生の臨床前基礎実習において透明根管模型歯は、全ての学生が同一条件下で実習を行えることや、根管治療における各ステップを目視できる等の利点がある。今回、本学歯学部4年次生47名が象牙質歯髄複合体診断・治療学実習の実技試験で根管充填を行った透明根管模型歯について、視診による評価と、デジタルX線画像のモニタ上での視診による評価、およびデジタルX線画像を画像解析ソフト(ImageJ)により解析した評価を行い、各評価法の妥当性について比較検討した。その結果、画像解析ソフトで解析する方法は成績の過小評価を防ぐうえで有用であり、より客観的な評価が可能と考えられた。

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.4103/njbcs.njbcs_44_17

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.15562/jdmfs.v4i1.855

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.oooo.2019.02.020.

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.5624/isd.2019.49.1.27.

DOI： 10.5624/isd.2019.49.1.27

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記述言語：日本語   出版者・発行元：日本画像医学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11282-018-0365-5.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.4317/medoral.22592

担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11282-018-0364-6.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s10266-019-00443-5.

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.15562/jdmfs.v3i3.768

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.oraloncology.2018.09.030.

記述言語：英語  

Overexpression and increased signaling from the epidermal growth factor receptor (EGFR) often changes oral squamous cell carcinoma (OSCC) and thus EGFR is frequently targeted molecularly by the therapeutic antibody cetuximab. We assessed the roles of OSCC-derived extracellular vesicles (EVs), including exosomes in the trafficking of cetuximab and in epithelial-mesenchymal transition (EMT) of epithelial cells. OSCC cells abundantly expressed EGFR, which was secreted from cells with OSCC-EVs upon EGF stimulations. The OSCC-EGFR-EVs were then able to enter into and transform epithelial cells leading to increased mesenchymal traits with increased vimentin and spindle-like shapes. EGF priming of OSCC cells further increased this EMT-initiating effect of the OSCC-EVs. The internalization and pro-EMT effects of the OSCC-EVs were largely blocked by cetuximab. Thus, OSCC-derived EVs transform normal epithelial cells into a mesenchymal phenotype and anti-EGFR therapeutic antibody cetuximab inhibits such a carcinogenic effect of the OSCC-EVs.

DOI： 10.1016/j.oraloncology.2018.09.030

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fonc.2018.00376

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.bbrc.2018.07.035

記述言語：英語  

Genetic amplification, overexpression, and increased signaling from the epidermal growth factor receptor (EGFR) are often found in oral squamous cell carcinoma (OSCC) and thus EGFR is frequently targeted molecularly by the therapeutic antibody cetuximab. We assessed effects of cetuximab in control of EGF-driven malignant traits of OSCC cells. EGF stimulation promoted progression level of mesenchymal traits in OSCC cells, which were attenuated by cetuximab but incompletely. We pursued a potential mechanism underlying such incomplete attenuation of OSCC malignant traits. Cetuximab promoted secretion of EGFR-EVs by OSCC cells and failed to inhibit EGF-driven secretion of EGFR-EVs. Cetuximab was also found to be robustly secreted with the EGFR-EVs by the OSCC cells. Thus, EGF promotes the level of mesenchymal traits of OSCC cells and secretion of EGFR-EVs, which involve cetuximab resistance.

DOI： 10.1016/j.bbrc.2018.07.035

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11282-017-0306-8.

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18926/AMO/56167.

担当区分：最終著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語   出版者・発行元：岐阜大学医学教育開発研究センター  

岡山大学歯学部は、平成26年に岡山大学が採択された文部科学省課題解決型高度医療人材養成プログラム選定事業「健康寿命社会を担う歯科医学教育改革-死生学や地域包括ケアモデルを導入した医科歯科連携教育体制の構築-」の中で、岡山大学病院で展開されているチーム医療の現場を体験する「高度医療支援・周術期口腔機能管理実習」を必須科目として開講している。本実習は、単なる知識の習得ではなく、チーム医療の現場で専門性をもって積極的に対応できる歯科医療人養成を目的としており、現在は岡山大学の学生だけでなく、上記事業の連携大学からの学生受け入れも行っている。本実習は、チーム医療の現場を実際に経験させるだけでなく、学生にがん手術予定の患者及び患者家族をエスコートするという役割を与えたことで、学習内容が印象に残り、医療職としてのプロフェッショナリズムを育む可能性があることが示唆された。(著者抄録)

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記述言語：英語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：英語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.5037/jomr.2018.9204

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1259/dmfr.20170369

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11282-017-0285-9.

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1259/dmfr.20170412

記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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DOI： 10.1259/dmfr.20170412

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DOI： 10.1259/dmfr.20170369

PubMed

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.14295/bds.2018.v21i2.1557

掲載種別：研究論文（学術雑誌）   出版者・発行元：Lepidus Tecnologia  

DOI： 10.14295/bds.2018.v21i2.1557

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

当院で口腔および中咽頭癌に対する放射線治療を受けた60例(口腔癌42例、中咽頭癌18例)を対象とし、放射線性下顎骨壊死(以下ORN)のリスク因子について後方視的に検討を行った。ORNは7例(12%)で認められ、発生までの期間は1〜53ヵ月(中央値15ヵ月)であった。下顎骨全体の検討では放射線治療前1ヵ月以内の抜歯の既往、平均線量(中央値51Gy)とV40およびV50(40Gy、50Gyが照射される下顎骨の体積)に有意差が認められた。片顎ずつの検討では、平均線量およびV40に有意差が認められた。多変量解析で下顎骨全体の検討での放射線治療前1ヵ月以内の抜歯の既往に有意差が認められ、片顎ずつの検討では認められなかったことから、要抜去歯を有する患者はORN発生のリスクが高いと考えられた。ORNを予防するためには、下顎骨に対する最大線量の制約に加え、平均線量の制約を組み込む必要があると考えられた。(著者抄録)

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記述言語：日本語   出版者・発行元：(株)文光堂  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Universidade de Sao Paulo, Agencia USP de Gestao da Informacao Academica (AGUIA)  

Chronic periapical lesion is among the most usual bone pathology observed in human teeth, and it is often first detected by plain radiographs, such as panoramic or periapical radiography. Plain radiographs are widely used in dentistry; however, they have limitations inherent to the technique itself, such as anatomic structures overlapping and lack of information on the extension of the lesion. Therefore, three-dimensional radiographic methods, such as cone beam computed tomography are valuable to accurately assess periapical lesions. Thus, this clinical report describes a case in which the bone radiographic features led to a primary diagnosis of chronic periapical lesion in superior incisors, however, it was a defect in the palatal bone. The resulting radiolucency created by the palatal bone defect overlapped the maxillary bone, mimicking a periapical lesion. Additionally, in the same case, we demonstrate a true chronic periapical lesion in another area that presented as a subtle radiolucency in periapical radiography, however, it was larger than expected when evaluated in Cone Beam Computed Tomography.

DOI： 10.11606/issn.2357-8041.clrd.2017.140721

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18926/AMO/55663.

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2174/1874210601812010012

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3892/mco.2017.1478.

DOI： 10.3892/mco.2017.1478

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.2485/jhtb.27.275

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.5981/jjhnc.44.57

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2174/1874210601812010012

PubMed

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DOI： 10.3389/fonc.2018.00376

PubMed

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Medicina Oral, S.L.  

DOI： 10.4317/medoral.22592

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：英語   出版者・発行元：(NPO)日本歯科放射線学会  

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DOI： 10.1016/j.jdsr.2016.09.003

PubMed

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記述言語：日本語   出版者・発行元：日本口腔顎顔面技工学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(一社)日本癌治療学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(一社)歯科基礎医学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

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記述言語：日本語   出版者・発行元：日本再生歯科医学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(公社)日本歯科医師会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JOURNAL HARD TISSUE BIOLOGY  

The purpose of this study was to determine the accuracy of a new high resolution digital camera-based three-dimensional system called Di3D by comparing with traditional direct anthropometry using digital calipers. The study sample consisted of 20 young adults, 10 male and 10 female. Facial soft tissue landmarks were identified and five linear distances were measured between the landmarks for each subject using the two methods; Di3D camera system and a digital caliper. No statistically significant differences (P &gt; 0.05) were found for all five facial soft tissue distances measured by the Di3D camera system and the digital caliper. The magnitude of differences was very small (mean = 0.73 mm). Good congruence was observed between the means derived from the Di3D system and the digital caliper.
The overall mean differences of the five measurements with these two methods were small enough to be clinically insignificant. The results show that both methods are concordant and one method can replace the other in clinical use.

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.tripleo.2011.07.038

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：日本画像医学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：日本画像医学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Odontoma is the most common type of benign odontogenic tumor, and often causes disturbances in the eruption of its associated tooth. Odontomas usually occur in the permanent dentition, and rarely occur solely in the primary dentition. This case report documents a six-year-old-child with a compound odontoma located in the mandible, which caused the impaction of the primary second molar.

DOI： 10.2174/1874210600903010173

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVES: To compare MRI manifestations according to gender and age and to identify correlations between clinical manifestations and MRI findings in patients with temporomandibular disorder (TMD) as based on a large series. MATERIALS AND METHODS: Fat suppressed oblique sagittal images of the open and closed mouth were acquired, and MRI scanning parameters were applied. RESULTS: The patients consisted of 946 females (average, 36.6 years old), and 319 males (average, 34.3 years old). In all TMD patients, 945 had symptoms in the unilateral temporomandibular joint (TMJ) and 320 in the bilateral TMJ. There were significant differences in the distribution of disk positions based on age, regardless of gender, in the unilaterally and bilaterally symptomatic groups; however, the results were not significant in the asymptomatic group. There were significant differences with respect to the distribution of disk positions between males and females in asymptomatic group and in the unilaterally symptomatic group, although the bilaterally symptomatic group did not show significant differences in this regard. As regards the disk positions in the joints of the three groups (asymptomatic group, unilaterally and bilaterally symptomatic groups), there were significant interactive effects of disk positions, regardless of gender. There were statistically significant age-related differences in disk deformities in all symptom groups, regardless of gender, except for in the group of males lacking symptoms in either joint. As regards disk deformities among the three groups studies here, there were significant interactive effects for disk positions, regardless of gender.

DOI： 10.2174/1874210600903010001

PubMed

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：日本画像医学会  

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記述言語：日本語   出版者・発行元：日本画像医学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(一社)日本医学教育学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(公社)日本放射線腫瘍学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：日本画像医学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：日本癌学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

We investigated the relationship between the enhanced patterns acquired by dynamic MRI and the tumor cell proliferation estimated by immunostaining proliferating cell nuclear antigen (PCNA) in oral squamous cell carcinoma (SCC). Thirty patients with primary oral SCC underwent dynamic contrast enhanced (DCE)-MRI using a three-dimensional fast imaging with steady-state precession sequence. Tumor cell proliferation of all surgical specimens was evaluated using immunohistochemical staining with the anti-PCNA antibody. The relationship between the dynamic MRI parameters (maximum CI and maximum CI gain) and the PCNA labeling index was statistically analyzed using regression analysis. The time contrast index curves of all cases showed a rapid and high uptake pattern. The PCNA labeling index showed a significant correlation with maximum CI and maximum CI gain (P&lt
0.0001, r=0.866 and P=0.0019, r=0.544, respectively). The assessment of DCE-MRI parameters may provide valuable information for tumor cell proliferation of the patients with oral cancer. © 2003 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S1368-8375(02)00119-7

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：日本画像医学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

We examined three patients with multiple synchronous Warthin's tumors in the bilateral parotid and described the value of using dynamic MRI. The time course of the contrast index (CI curves) was calculated from a dynamic series. Warthin's tumors showed intermediate signal intensity on T1WI, heterogeneous high and intermediate signal intensity on T2WI and a slight enhancement on Gd-T1WI. Warthin's tumors of CI curves showed specific findings. CI curves in each lesion showed the same pattern. It was difficult to diagnose masses as Warthin's tumors using only MR images on T1, T2 and Gd-T1WI. Dynamic MRI can distinguish Warthin's tumors from other possible tumors except for oncocytoma. Therefore, the use of dynamic MRI is recommended as a diagnostic method for Warthin's tumors in multiple synchronous lesions of the parotid gland. © 2002 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S1368-8375(01)00073-2

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記述言語：日本語   出版者・発行元：(一社)日本ハイパーサーミア学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(一社)日本ハイパーサーミア学会  

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記述言語：日本語   出版者・発行元：岡山大学医学部保健学科  

エールリッヒ腹水癌細胞とそのアドリアマイシン耐性細胞において蛍光pH指示薬2', 7'-bis-(2-carboxyethyl)carboxyfluorescein](BCECF)の蛍光量をフローサイトメトリーで測定することによって細胞内pHの検量曲線を作成することができた.このことより,これらの細胞においてBCECFの蛍光量で細胞内pHの変化を簡易に比較できることを示唆した.アミロライド[3, 5-diamino-6-chloro-N-(diaminomethylene)pyrazinecarboxamide],及びアミロライド誘導体MH-12-43[N-amidino-3-amino-6-chloro-5-(N-ethyliso-propylamino)pyrazinecarboxyamide]の細胞内pHへの影響をエールリッヒ腹水癌細胞で観察した.37℃では,0.5mMアミロライド,0.05mM MH-12-43により細胞内pHは減少し,42℃処理により更に減少した.42℃において,0.05mM MH-12-43による細胞内pHの減少は,0.5mMアミロライドによる減少より大きかった

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=1996&ichushi_jid=J02722&link_issn=&doc_id=19960426330001&doc_link_id=http%3A%2F%2Fousar.lib.okayama-u.ac.jp%2F11730&url=http%3A%2F%2Fousar.lib.okayama-u.ac.jp%2F11730&type=%89%AA%8ER%91%E5%8Aw%81F%89%AA%8ER%91%E5%8Aw%8Aw%8Fp%90%AC%89%CA%83%8A%83%7C%83W%83g%83%8A&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80034_3.gif

記述言語：日本語   出版者・発行元：Japanese Society for Thermal Medicine  

The authors developed and evaluated the performance, using a phantom, of a new capacitive heating applicator designed for the "parallel method" of applying clinical simultaneous radiohyperthermotherapy (SRH) in which electron beam irradiation is provided from above an external capacitive heating applicator for the treatment of superficial and shallow-seated tumors. The trial applicator was made to fulfill the following conditions : (1) use of an electrode plate which does not affect the electron beam depth dose, (2) a uniform tickness to maintain flatness of the electron beam, (3) an attachment site between the electrode and lead wire at the electrode margin to avoid entering the irradiation field, and (4) cooling function to enhance therapeutic gain factor and avoid damage to normal skin tissue. This applicator consisted of a 0.1-mm-thick copper electrode and a 5-mm-thick cooling chamber. The depth of the 80% dose of the new applicator was 21 mm with a 9-MeV electron beam and 36 mm with a 15-MeV electron beam, which was comparable to the effect of a conventional irradiation bolus. The temperature distribution produced by the trial applicator was symmetrical on both the right and left from the center of the applicator. The 50% specific absorption rate region was a width of 6.4 cm at a depth of 1 cm from the phantom surface and a width of 2.8 cm at a depth of 3 cm. There have been no previous reports on the development of an external capacitive heating applicator designed for the SRH of superficial and shallow-seated tumors; this is the first report. SRH of these tumors can be performed simply, noninvasively and repeatedly by means of this new applicator.

DOI： 10.3191/thermalmedicine.10.189

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記述言語：日本語   出版者・発行元：岡山医学会  

NIH3T3細胞における塩化ベンザルコニウムの温熱耐性誘導能を調べた.1)塩化ベンザルコニウムの濃度上昇,接触時間延長とともに細胞毒性が増加した.0.002%塩化ベンザルコニウムの20分間処理にて,細胞の生存率は無処理細胞と比べて50%に減少した.2) 0.002%塩化ベンザルコニウムの20分間処理後の培養中に温熱耐性が誘導され,処理後15時間目に最大となり,以後徐々に消失した.処理後15時間目の45°C加温にて,対照群と比べてD0比で3.8倍の温熱耐性が出現した.3) 0.002%塩化ベンザルコニウムにて誘導される温熱耐性の大きさは,その処理時間が長くなるにしたがって大きくなった.以上の結果より,塩化ベンザルコニウム処理による細胞膜障害と温熱耐性誘導との間に関連性が示唆された

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=1993&ichushi_jid=J00175&link_issn=&doc_id=19870035300005&doc_link_id=http%3A%2F%2Fousar.lib.okayama-u.ac.jp%2F13929&url=http%3A%2F%2Fousar.lib.okayama-u.ac.jp%2F13929&type=%89%AA%8ER%91%E5%8Aw%81F%89%AA%8ER%91%E5%8Aw%8Aw%8Fp%90%AC%89%CA%83%8A%83%7C%83W%83g%83%8A&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80034_3.gif

記述言語：日本語   出版者・発行元：日本ハイパーサーミア学会  

Simultaneous radiohyperthermotherapy (SRH) is a combined hyperthermia-radiation therapy in which radiation is given during heating. An in vitro study was performed on NIH3T3 cells using ⁶⁰Co γ-ray for irradiation and a water bath for heat treatment. The thermal enhancement ratio increased after simultaneous treatment compared to sequential treatment with heating for 90 min at 43°C and irradiation. Simultaneous treatment was more cytotoxic than sequential treatment with heating for 20 min at 45°C and irradiation of 6 Gy. A clinical trial was performed on a 57-year-old female with post-operative recurrence of rectal carcinoma. This is the first reported clinical case treated with true SRH in which external irradiation was administered during mid RE capacitive heating. Twelve SRH treatments were performed on the recurrent lesion at a frequency of twice a week for six weeks using the high energy radiotherapy system (Toshiba LMR-15A) and the 13.56MHz capacitive heating system (Omron HEH-500C). Average temperature at the time of irradiation in mid heating was 41.1°C. The patient received 60 Gy in 30 fractions over six weeks. There was a dramatic reduction in pain after treament. The tumor marker CEA level decreased after treatment. On CT images taken after treatment, the tumor site became a low density area which indicated necrosis. There were no side effects encountered. These results suggest that further clinical study of SRH should be performed to clarify its advantages.

DOI： 10.3191/thermalmedicine.8.326

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記述言語：日本語   出版者・発行元：日本ハイパーサーミア学会  

An adriamycin (ADR) -resistant cell line derived from Ehrlich ascites tumor cells (wild EATC) was established in our laboratory. In this report, difference for thermosesitivity and thermotolerance between wild EATC and ADR resistant EATC were observed. ADR uptake and killing effect of ADR in thermoresistant-induced wild EATC in comparison with non-treated wild EATC also were evaluated.<BR>1) There was no difference for thermosensitivity between wild EATC and ADR resistant EATC.<BR>2) ADR resistant EATC showed bigger magnitude of thermotolerance than wild EATC.<BR>3) ADR uptake in thermoresistant-induced wild EATC showed no change in comparison with that in wild EATC. The killing effect of ADR also had no change in both cells.

DOI： 10.3191/thermalmedicine.8.291

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記述言語：日本語   出版者・発行元：日本ハイパーサーミア学会  

DOI： 10.3191/thermalmedicine.8.1

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記述言語：日本語   出版者・発行元：日本ハイパーサーミア学会  

Simultaneous radiohyperthermotherapy (SRH) is a combined hyperthermia-radiation therapy in which radiation is given during heating. Mutual interference between the high energy radiotherapy system (Toshiba LMR-15A) and the 13.56MHz capacitive heating system (Omron HEH-500C) was examined using phantoms prior to clinical trials. Phantoms were irradiated and heated simultaneously at right angles. The energy and flatness of irradiation were measured using films and were not affected by the heating system within the range of clinical use. The temperature increase was measured with a thermocouple thermometer, and the temperature distribution was determined by liquid crystal thermometer. The high energy radiotherapy system did not affect the heating device set power, the temperature increase and distribution during simultaneous ti eatiiieiiL. This study clarified that these apparatuses work simultaneously without clinically significant mutual interference. SRH using these apparatuses can be safely applied to clinical study.

DOI： 10.3191/thermalmedicine.8.318

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記述言語：日本語   出版者・発行元：Japanese Society of Oral and Maxillofacial Surgeons  

Verrucous carcinoma, a variant form of well-differentiated squamous cell carcinoma, was first described by Ackerman in 1948. In Japan, following a case of buccal mucous membrane reported in 1967 by Kozaki et al., 50 cases were since reported.<BR>We reported 2 cases of verrucous carcinoma of tongue and palate, and review of the literature.

DOI： 10.5794/jjoms.36.377

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その他リンク： http://search.jamas.or.jp/link/ui/1990207555

記述言語：日本語   出版者・発行元：Japanese Society of Oral and Maxillofacial Surgeons  

Clinicostatistical observation was made into 34 cases of mandibular condylar fracture in children under 15 years by reviewing recent results of treatment given at our hospital during the past 16 years, from April 1971 to March 1987. Results obtained were as follows:<BR>1. Fractures to the condyle were diagnosed in 58.6% of 58 cases of childhood mandibular fractures.<BR>2. Of 34 cases, 26 cases showed fractures to the condayle combined with other fractures of the mandible.<BR>3. Closed reduction was performed in 26 cases.<BR>4. Open reduction was performed in 8 cases and condylar process was performed in only 1 case which showed combined subcondylar and other mandibular fractures.<BR>5. Long-term follow-up study gave the following results:<BR>1) Disturbances were found to bear some relation to age.<BR>2) Open reduction for condylar process fracture was performed in 1 case, showing good prognosis.<BR>3) There was no obvious difference in the clinical course between closed and open reduction.<BR>4) Temporo-mandibular movement and range of movement were satisfactorily restored, but in most cases deformity of the condylar process remained.<BR>5) 3 cases with growth disturbance of the mandible were observed.

DOI： 10.5794/jjoms.35.983

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その他リンク： http://search.jamas.or.jp/link/ui/1990062399

総ページ数：282   担当ページ：255   記述言語：日本語 著書種別：教科書・概説・概論

総ページ数：282   担当ページ：105   記述言語：日本語 著書種別：教科書・概説・概論

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記述言語：日本語   出版者・発行元：日本法歯科医学会  

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記述言語：英語   掲載種別：書評論文，書評，文献紹介等   出版者・発行元：Springer Tokyo  

Background: Oral and maxillofacial radiology became the ninth dental specialty recognized by the American Dental Association (ADA) in 1999. This came about following the discovery of X-rays by Wilhelm Conrad Roentgen in 1895 and, 14 days later, the application of X-rays to making dental radiographs by Otto Walkhoff. The purpose of this narrative study was to review the evolution of oral and maxillofacial radiology as a dental specialty in the USA and its recognition as a program of training by the West African College of Surgeons. Methods: This study was conceptualized as a narrative review of the literature focusing on the history and development of oral and maxillofacial radiology in the USA. It builds a synthesis that describes the recognition of oral and maxillofacial radiology as a specialty of dentistry in West Africa, UK, Japan, and Australia. Results: The main finding was that oral and maxillofacial radiology became the ninth specialty recognized by the American Dental Association, ADA, in October 13, 1999. On March 20, 2014, the West African College of Surgeons recognized this specialty and granted accreditation for postgraduate training. In the UK, Japan, and Australia, the postgraduate education in oral and maxillofacial radiology has two patterns, namely professional training and academic training. Conclusions: The primary goal of the postgraduate training curriculum is to train radiologists who are competent to deliver care to patients in any clinical setting, including a dental school, hospital radiology practice, or private practice.

DOI： 10.1007/s11282-017-0285-9

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記述言語：日本語   出版者・発行元：日本法歯科医学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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© 2018, Society of Hard Tissue Regenerative Biology. All rights reserved. Contrast-enhanced (CE)-MR image is useful to distinguish cystic and solid portions on multilocular lesion, however, the CE-MR examination is contraindicated in patients with kidney disease. Fluid-attenuated inversion recovery (FLAIR) image is one of methods which signal of fluid is suppressed. This study investigated qualitatively and quantitative-ly whether FLAIR images were useful for detecting and differentiating cystic and solid portions of multilocular ameloblastomas. We retrospectively reviewed 11 cases of multilocular ameloblastoma. FLAIR and short T1 inversion recovery (STIR) sequences were performed in all cases, CE-MR images in 10 cases, and T1-weighted images (T1WI) in 7 cases. FLAIR, STIR, CE-MR, and T1WI images were visually evaluated (qualitative analysis). Signal-to-noise ratio (SNR) of cystic and solid portions were measured and compared among the images of all sequences (quantitative analysis). FLAIR imaging could detect cystic portions with very low SI in all cases because cystic fluid was well suppressed on the images, and the solid portion showed intermediate SI. On some STIR images, the solid portion was masked by the markedly high SI of the cystic fluid. CE-T1WI and CE-FLAIR images showed no enhancement of the cystic portion but enhancement of the solid portion. On FLAIR image, SNR of solid was higher than cystic portion (p &lt; 0.05). Cystic and solid portions of a lesion could be detected and distinguished on FLAIR imaging. FLAIR images are thus useful for diagnosing multilocular ameloblastoma when CE-MR cannot be performed.

DOI： 10.2485/jhtb.27.275

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記述言語：日本語  

J-GLOBAL

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J-GLOBAL

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DOI： 10.18926/AMO/56167

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：生命科学系学会合同年次大会運営事務局  

J-GLOBAL

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記述言語：英語  

DOI： 10.1007/s11282-017-0306-8

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PubMed

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：英語   出版者・発行元：AMER SOC NEURORADIOLOGY  

BACKGROUND AND PURPOSE: Osteoma cutis of the face represents a primary or secondary formation of ossific foci in the facial skin. Its primary form has been sparsely described in the plastic surgery and dermatology literature. As radiologists, we routinely encounter incidental, very small facial calcified nodules on CT studies performed for a variety of unrelated reasons. We hypothesized that this routinely encountered facial calcification represents primary miliary osteoma cutis and is a common, benign, age-related finding.
MATERIALS AND METHODS: We retrospectively reviewed 1315 consecutive sinus CTs obtained during an 8-month period and their associated demographics. The number of dermal radiopaque lesions with Hounsfield units of &gt;150 was counted, and we analyzed the association between the prevalence of these lesions and patients' demographics with logistic regression methods.
RESULTS: Five hundred ninety-nine males and 716 females from 4 to 90 years of age were included in the study (mean, 52 versus 51 years; P =.259). Among these, 252 males and 301 females had small facial calcified nodules (42.1% versus 42.0%, P =.971). The patient's age was a statistically significant predictor for having facial calcified nodules (odds ratio = 1.02, P &lt;.001), while the patient's sex was not (P =.826).
CONCLUSIONS: Facial calcified nodules, observed in routine head and face CT imaging, are common, benign, age-related findings, which have been largely overlooked in the radiology literature. It is a manifestation of primary miliary osteoma cutis.

DOI： 10.3174/ajnr.A5096

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記述言語：英語   出版者・発行元：SPANDIDOS PUBL LTD  

Salivary gland carcinomas are rare tumors, representing similar to 0.5% of all malignancies. Myoepithelioma is also uncommon, representing similar to 1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases arising from a submandibular gland in a 71-year-old male patient and present the associated imaging findings. The patient was considered to have a de novo type of myoepithelial carcinoma, which is reportedly associated with higher malignancy than the transformation type of the disease (i.e., a malignant change from pleomorphic adenoma or myoepithelioma). This was reflected in the multiple lung and bone metastases sites and strong positivity for p53 and Ki-67.

DOI： 10.3892/ol.2017.5783

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記述言語：英語   出版者・発行元：Korean Academy of Oral and Maxillofacial Radiology  

Mandibular bone depression, also known as Stafne bone cavity, is defined as a bone depression filled mainly with salivary gland tissue. Parotid gland bone defects are infrequently observed. We report the case of a 52-yearold male patient who underwent radiographic examinations due to temporomandibular joint dysfunction, and a radiolucent area was detected in the mandibular ramus, with a provisional diagnosis of traumatic bone cyst or parotid mandibular bone defect. The patient was then referred for magnetic resonance imaging, which demonstrated a hyperintense area eroding the mandibular ramus, which corresponded to glandular tissue. Although the defect was a benign lesion, radiolucencies in the mandibular ramus lead to concerns among professionals, because their radiographic features can resemble various intrabony neoplastic lesions, such as giant cell tumors or benign tumors of the parotid gland.

DOI： 10.5624/isd.2017.47.4.269

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記述言語：英語  

DOI： 10.23736/S0026-4970.17.03971-1

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記述言語：日本語   出版者・発行元：(NPO)日本法医学会  

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記述言語：日本語   出版者・発行元：(一社)日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：日本歯科医学教育学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

J-GLOBAL

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記述言語：英語   出版者・発行元：SPRINGER  

DOI： 10.1007/s11282-016-0244-x

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

J-GLOBAL

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記述言語：英語   出版者・発行元：Korean Academy of Oral and Maxillofacial Radiology  

Purpose: The aim of this study was to assess and compare the diagnostic performance of panoramic and occlusal radiographs in detecting submandibular sialoliths. Materials and Methods: A total of 40 patients (20 cases and 20 controls) were included in this retrospective study. Cases were defined as subjects with a submandibular sialolith confirmed by computed tomography (CT), whereas controls did not have any submandibular calcifications. Three observers with different expertise levels assessed panoramic and occlusal radiographs of all subjects for the presence of sialoliths. Intraobserver and interobserver agreement were assessed using the kappa test. Sensitivity, specificity, accuracy, positive and negative predictive values, and the diagnostic odds ratio of panoramic and occlusal radiographs in screening for submandibular sialoliths were calculated for each observer. Results: The sensitivity and specificity values for occlusal and panoramic radiographs all ranged from 80% to 100%. The lowest values of sensitivity and specificity observed among the observers were 82.6% and 80%, respectively (P=0.001). Intraobserver and interobserver agreement were higher for occlusal radiographs than for panoramic radiographs, although panoramic radiographs demonstrated a higher overall accuracy. Conclusion: Both panoramic and occlusal radiographic techniques displayed satisfactory diagnostic performance and should be considered before using a CT scan to detect submandibular sialoliths.

DOI： 10.5624/isd.2016.46.2.87

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DOI： 10.11242/dentalradiology.55.47

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DOI： 10.11242/dentalradiology.55.49

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記述言語：日本語   出版者・発行元：岡山歯学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：英語   出版者・発行元：BIOMED CENTRAL LTD  

Background: High-dose-rate (HDR) brachytherapy using the mold technique is a less invasive treatment for early lip and oral cavity cancer. However, limited reports exist regarding the feasibility of this method. In this retrospective study, we evaluated the outcome of this therapy and investigated its feasibility for lip and oral cavity tumors.
Methods: Between May 2002 and December 2010, 17 patients (median age, 80.0 years) with histologically confirmed squamous cell carcinoma of the lip or oral cavity were treated by means of HDR brachytherapy using the mold technique after external beam radiotherapy (EBRT). Tumor sites included the buccal mucosa in eight cases, the gingiva in three cases, the lips in two cases, the floor of the mouth in two cases, and the hard palate in two cases. For all patients, EBRT (30 Gy/15 fractions), was performed before HDR brachytherapy. Two 6-Gy fractions were delivered twice daily for 2 days a week with an interval of 6 hours between the fractions. The total HDR brachytherapy dose was 24 Gy. Prior to EBRT, two patients with neck metastasis underwent neck dissection, and one patient with an exophytic tumor underwent tumor resection.
Results: The median follow-up period was 53.4 (range, 4.8-83.4) months. Of the 17 patients, 14 (82.4%) achieved a complete response, and three (17.6%) displayed a partial response. The overall 3-and 5-year survival rates were both 68.8%, the 3-and 5-year disease-specific survival rates were both 86.7%, and the 3-and 5-year local control rates were both 54.1%. Seven patients developed local recurrence at a median time of 3.4 (range, 1.7-29.1) months after treatment. Nodal and lung metastases occurred separately in two patients. By the end of the follow-up period, two patients had died of the primary disease and four patients had died of other causes.
Conclusions: Although there is a need to improve the technical aspects of the treatment protocol, HDR brachytherapy using the mold technique might be a therapeutic option for superficial lip or oral cavity tumors, especially in older patients who have a poor performance status or are in poor physical condition.

DOI： 10.1186/s13014-015-0390-z

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記述言語：日本語   出版者・発行元：(NPO)日本歯科放射線学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：日本画像医学会  

J-GLOBAL

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記述言語：英語   出版者・発行元：SPANDIDOS PUBL LTD  

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare type of odontogenic carcinoma arising from the jawbone. Odontogenic cysts are true cysts that arise from the dental epithelium, which is associated with tooth formation. The epithelial lining of odontogenic cysts has the potential to transform into various types of odontogenic tumor; however, this transformation from an odontogenic cyst to a malignant tumor is rare. The definitive diagnosis for PIOSCC generally requires the observation of either features of squamous cell carcinoma (SCC) within the jawbone that are distinct from direct invasion from the surface oral epithelium, or evidence of SCC arising from odontogenic epithelium and from tumors that have metastasized to the jawbone from distant sites. In the present study, a case of PIOSCC of the maxilla is presented, which, based on the results of computed tomography and the clinical course, was hypothesized to have originated from an infected residual cyst.

DOI： 10.3892/ol.2014.2644

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記述言語：日本語   出版者・発行元：岡山歯学会  

J-GLOBAL

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記述言語：英語   出版者・発行元：BIOMED CENTRAL LTD  

Background: Intermediate-to-high-risk prostate cancer can locally invade seminal vesicle (SV). It is recommended that anatomic proximal 1-cm to 2-cm SV be included in the clinical target volume (CTV) for definitive radiotherapy based on pathology studies. However, it remains unclear whether the pathology indicated SV extent is included into the CTV defined by current guidelines. The purpose of this study is to compare the volume of proximal SV included in CTV defined by EORTC prostate cancer radiotherapy guideline and RTOG0815 protocol with the actual anatomic volume.
Methods: Radiotherapy planning CT images from 114 patients with intermediate-(36.8%) or high-risk (63.2%) prostate cancer were reconstructed with 1-mm-thick sections. The starting and ending points of SV and the cross sections of SV at 1-cm and 2-cm from the starting point were determined using 3D-view. Maximum (D-1H, D-2H) and minimum (D-1L, D-2L) vertical distance from these cross sections to the starting point were measured. Then, CTV of proximal SV defined by actual anatomy, EORTC guideline and RTOG0815 protocol were contoured and compared (paired t test).
Results: Median length of D-1H, D-1L, D-2H and D-2L was 10.8 mm, 2.1 mm, 17.6 mm and 8.8 mm (95th percentile: 13.5mm, 5.0mm, 21.5mm and 13.5mm, respectively). For intermediate-risk patients, the proximal 1-cm SV CTV defined by EORTC guideline and RTOG0815 protocol inadequately included the anatomic proximal 1-cm SV in 62.3% (71/114) and 71.0% (81/114) cases, respectively. While for high-risk patients, the proximal 2-cm SV CTV defined by EORTC guideline inadequately included the anatomic proximal 2-cm SV in 17.5% (20/114) cases.
Conclusions: SV involvement indicated by pathology studies was not completely included in the CTV defined by current guidelines. Delineation of proximal 1.4 cm and 2.2 cm SV in axial plane may be adequate to include the anatomic proximal 1-cm and 2-cm SV. However, part of SV may be over-contoured.

DOI： 10.1186/s13014-014-0288-1

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：ELSEVIER SCIENCE INC  

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記述言語：英語   出版者・発行元：SPANDIDOS PUBL LTD  

The aim of this study was to create a new phantom for a 3 Tesla (3T) magnetic resonance imaging (MRI) device for the calculation of the apparent diffusion coefficient (ADC) using diffusion-weighted imaging (DWI), and to mimic the ADC values of normal and tumor tissues at various temperatures, including the physiological body temperature of 37 C. The phantom was produced using several concentrations of sucrose from 0 to 1.2 M, and the DWI was performed using various phantom temperatures. The accurate ADC values were calculated using the DWIs of the phantoms, and an empirical formula was developed to calculate the ADC values of the phantoms from an arbitrary sucrose concentration and arbitrary phantom temperature. The empirical formula was able to produce ADC values ranging between 0.33 and 3.02x10(-3) mm(2)/sec, which covered the range of ADC values of the human body that have been measured clinically by 3T MRI in previous studies. The phantom and empirical formula developed in this study may be available to mimic the ADC values of the clinical human lesion by 3T MRI.

DOI： 10.3892/ol.2014.2187

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：英語   出版者・発行元：SPRINGER  

It is known that the magnetic resonance (MR) imaging features of dentigerous cysts (DCs) are the same as those of other cysts. The cavities of DCs generally show low signal intensity (SI) on T1-weighted imaging (T1WI). However, in our experience, DCs often show high SI on T1WI, rendering them difficult to distinguish from keratocystic odontogenic tumors (KCOTs). In this study, we evaluated seven cases of DC and 23 cases of KCOT to assess whether MR imaging can provide additional information for the differential diagnosis of DC and KCOT.Two trials were evaluated. The first trial was an analysis of the cystic cavity SI on T1WI. To compare the SI between patients, we performed T1WI with contrast (T1c). The second trial analyzed the SI uniformity (U (I )) pound on T1WI, T2-weighted imaging (T2WI), and short inversion time inversion recovery (STIR) images of the cystic cavity, because it has been reported that an MR imaging feature of KCOT is heterogeneous SI. Statistical analyses were performed using the Mann-Whitney U test and a receiver operating characteristic (ROC) curve.The T1c values of DCs were significantly higher than those for KCOTs. The U (I ) pound values on T1WI and STIR images were significantly higher for DCs than for KCOTs. The T1c cutoff values (0.66 and 0.84) and U (I ) pound cutoff values for T1WI (82.1 %) and STIR images (79.8 %) were determined from the ROC analyses.T1c and U (I ) pound values provide useful additional information for the differential diagnosis of DC and KCOT.

DOI： 10.1007/s11282-013-0128-2

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記述言語：英語   出版者・発行元：SPRINGER  

We previously reported that dynamic contrast-enhanced MRI parameters and time-signal intensity curves (TICs; also known as contrast index curves) are useful for the differential diagnosis of jawbone lesions. In particular, odontogenic fibroma and ossifying fibroma, which possess similar histopathological features (i.e., a mixture of hard and soft tissue components), display unique TIC patterns, and we consider that the TIC patterns of these lesions reflect their hard and soft tissue components. Therefore, fibrous dysplasia, which contains fibrous tissue and immature isolated trabeculae composed of woven bone, is expected to display an interesting TIC. The purpose of this study was to assess the utility of TICs for differentiating between the abovementioned lesions, which have similar histopathological components.

DOI： 10.1007/s11282-013-0137-1

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DOI： 10.11606/issn.2357-8041.clrd.2014.68234

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DOI： 10.1259/dmfr.20120265.

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DOI： 10.1186/1748-717X-8-169.

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記述言語：日本語   出版者・発行元：日本口腔顎顔面外傷学会  

症例は53歳男性で、飲酒後に数人から殴打され、救命救急科へ搬送された。X線で左上顎洞後壁、蝶形骨翼状突起基部から眼窩底部に骨折を認め、下顎骨ではオトガイ部骨折および切痕から左顎関節突起基底部に骨折線がみられた。下顎骨骨折については咬合偏位が著明で、抗凝固療法中であることより早期の手術を計画した。眼窩下壁骨折は眼科で左眼窩底部骨片圧迫による下直筋障害を指摘され、手術適応と判断された。下直筋障害増悪を認めたため、第6病日に下顎骨骨折および眼窩骨折の整復術を施行した。眼窩下壁骨折は、上顎洞後壁が前方に偏位し外眼筋を圧迫していたため、経結膜切開による眼窩アプローチを選択し、眼窩前方から骨折部を明示して眼窩内に偏位していた骨片を整復した。良好な眼球運動機能改善が得られ、眼窩底部の再建は行わなかった。術後経過良好で、複視症状や咬合不全も改善した。

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

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記述言語：英語   出版者・発行元：ELSEVIER SCIENCE INC  

DOI： 10.1016/j.oooo.2012.03.025

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記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）   出版者・発行元：日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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記述言語：英語   出版者・発行元：OXFORD UNIV PRESS  

The Radiation Therapy Oncology Group reported a maximum tolerated dose of 74 Gy for patients with non-small cell lung cancer (NSCLC); however, it was unclear whether this dose could be safely administered to Asian patients due to differences in their physique compared to Western patients. We therefore conducted a modified Phase I trial to determine whether 70 Gy could be safely delivered to Chinese patients with NSCLC undergoing 3D-conformal radiation therapy (3D-CRT) with concurrent chemotherapy. Previously untreated NSCLC patients received 3D-CRT (2 Gy/day, 5 fractions per week). Three dose levels were examined: 62, 66 and 70 Gy. Two cycles of concurrent chemotherapy (vinorelbine and carboplatin) were started on the first day of radiation therapy. Dose-limiting toxicity (DLT) was defined as severe or life-threatening side effects that altered the continued implementation of chemoradiotherapy. Among the 19 patients recruited in this study, most of the haematologic and non-haematologic toxicities were mild to moderate and clinically manageable. Only one patient, in the 70 Gy cohort, experienced a DLT of Grade 3 radiation-induced pneumonia. The overall response rate was 77.8% (14/18). The median progression-free survival (PFS) was 12 months, and the 1-year PFS was 37.6%. Our results support both the feasibility of incorporating 3D-CRT with concurrent vinorelbine and carboplatin and a dose escalation to 70 Gy for Chinese patients with NSCLC, based on the acceptable toxicity and encouraging overall response and survival rates. A further evaluation of this regimen in a prospective Phase II trial is ongoing.

DOI： 10.1093/jrr/rrs081

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記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語  

It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30 sec. Heating at 42° C was used to induce apoptosis while heating at 48°C was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3/um. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30 msec might be optimal to distinguish between apoptosis and necrosis.

DOI： 10.18926/AMO/52009

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J-GLOBAL

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記述言語：英語   出版者・発行元：ELSEVIER IRELAND LTD  

Objectives: To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) for differentiating between benign and malignant tumors in the palate.
Materials and methods: 26 patients with submucosal palatal tumors were preoperatively examined using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), and washout ratios (WR300 and WR600) were determined from contrast index curves. The submucosal palatal tumors were divided into two groups according to their Tmax values: the early enhancement group (Tmax &lt; 300 s) consisted of 9 malignant tumors and 6 benign tumors, while the late enhancement group (Tmax &gt;= 300 s) included one malignant tumor and 10 benign tumors. We compared the following DCE-MRI parameters between the benign and malignant tumors: CImax and Tmax in all cases and CImax, Tmax, and the washout ratios in the early enhancement group. In addition, we performed a regression analysis of the relationships between tumor size and DCE-MRI parameters; i. e., CImax, Tmax, and washout ratios, among the malignant salivary gland tumors and pleomorphic adenomas.
Results: In all cases and the early enhancement group, significant differences in Tmax were detected between the benign and malignant tumors (P &lt; 0.001 and P &lt; 0.05, respectively), and the optimal Tmax cutoff value for differentiating between them was found to be 165 s. None of the other parameters displayed significant differences between the benign and malignant tumors. Only the WR600 of the pleomorphic adenomas was significantly correlated with tumor size (R-2 = 0.92, P &lt; 0.001).
Conclusions: Tmax is a useful parameter for distinguishing between benign and malignant submucosal palatal tumors. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2012.04.009

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記述言語：英語   出版者・発行元：ELSEVIER SCIENCE INC  

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant odontogenic tumor arising from odontogenic epithelial remnants within the jawbones. PIOSCC is histopathologically divided into 3 types: solid-type carcinoma, carcinoma derived from a keratocystic odontogenic tumor, and carcinoma derived from an odontogenic cyst. In this article, we report a case of solid-type PIOSCC involving reactive bone formation in the mandible in a 60-year-old female patient together with its histopathological and imaging findings. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e71-e77)

DOI： 10.1016/j.oooo.2012.05.019

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記述言語：英語   出版者・発行元：ELSEVIER SCIENCE INC  

Ossifying fibroma (OF), a rare nonodontogenic tumor, is defined as a bone-related jawbone lesion. The main histopathological feature of OF is the replacement of bone by benign connective tissue. Ossifying fibroma usually occurs in the second to fourth decades of life and shows a predilection for females. Ossifying fibroma most commonly occurs in the mandible, and OF arising from the anterior part of the maxilla is rare. Ossifying fibromas display various radiographic findings, including varying degrees of radiolucency and radiopacity, depending on the proportions of their soft and hard tissue components. Depending on their components, it can be difficult to distinguish OF from other fibroosseous lesions and some odontogenic tumors by using conventional radiographs, computed tomography, and magnetic resonance imaging (MRI). We report a case of OF in the anterior maxilla in a 56-year-old man, together with its histopathological and imaging findings including the dynamic MRI findings. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e139-e146)

DOI： 10.1016/j.oooo.2012.04.015

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記述言語：英語   出版者・発行元：ELSEVIER IRELAND LTD  

Objective: To evaluate the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for minor salivary gland tumors in the oral cavity.
Materials and methods: Thirty-two patients with minor salivary gland tumors were examined preoperatively using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), Tpeak; i.e., the time that corresponded to the CImax x 0.90, and washout ratios (WR300 and WR600) were determined from contrast index (CI) curves. We compared these parameters between benign and malignant tumors and among the different histopathological types of minor salivary gland tumors. Then, we categorized the patients' CI curves into four patterns (gradual increase, rapid increase with high washout ratio, rapid increase with low washout, and flat).
Results: Statistically significant differences in Tmax (P = 0.004) and Tpeak (P = 0.002) were observed between the benign and malignant tumors. Regarding each histopathological tumor type, significant differences in Tmax (P &lt; 0.001), Tpeak (P &lt; 0.001), and WR600 (P = 0.026) were observed between the pleomorphic adenomas and mucoepidermoid carcinomas. It was difficult to distinguish between benign and malignant tumors using our CI curve classification because that two-thirds of the cases were classified into the same type (gradual increase).
Conclusion: The DCE-MRI parameters of minor salivary gland tumors contributed little to their differential diagnosis compared with those for major salivary gland tumors. During the diagnosis of minor salivary gland tumors, Tmax is useful for distinguishing between benign and malignant tumors. (c) 2011 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2011.11.005

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記述言語：英語   出版者・発行元：SPRINGER  

Lymphoepithelial cysts, which are also known as branchial cleft cysts, commonly occur in the lateral cervical region. Lymphoepithelial cysts arising in the parotid gland are rare and must be distinguished from parotid gland tumors. Magnetic resonance imaging (MRI) is useful for diagnosing parotid gland lesions, and MR images of lymphoepithelial cysts typically display a cystic mass that appears homogeneously hypointense on T1-weighted images and homogeneously hyperintense on T2-weighted images. However, some parotid gland tumors that retain fluid in their inner sections show similar MRI findings to lymphoepithelial cysts. Furthermore, lymphoepithelial cysts are sometimes modified by inflammation, and these cases are hard to diagnose. We report the case of a 59-year-old female with a lymphoepithelial cyst that arose in the parotid gland. The cyst had been affected by inflammation and displayed atypical imaging findings, i.e., heterogeneous signal intensity of the liquid component and the presence of a well-enhanced capsule-like structure surrounding the liquid component. In addition, we compare the MRI findings of this case with those of two other cervical lymphoepithelial cysts.

DOI： 10.1007/s11282-012-0086-0

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記述言語：英語   出版者・発行元：SPRINGER  

Adenoid cystic carcinoma (ACC) of the head and neck region is an uncommon epithelial tumor of the major and minor salivary glands. In the oral region, although ACC arising from the minor salivary glands is the second most commonly found tumor in the tongue base, its occurrence in the anterior part of the tongue is rare. Histopathologically, ACC is categorized into three growth patterns (tubular, cribriform, and solid types) and three histologic grades (I-III) that are based on the proportions of these patterns. According to this classification, tubular- and cribriform-type ACCs are considered to be lower grade lesions, while solid-type ACCs are considered to be higher grade lesions. A fourth histopathological type has recently been reported by some authors, namely, dedifferentiation or high-grade transformation of ACC. However, very few studies have focused on the imaging features of these ACCs. We report here the case of a 63-year-old female patient with ACC of the tongue with dedifferentiated components, together with the radiological images and pathological features of this ACC.

DOI： 10.1007/s11282-012-0097-x

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記述言語：英語   掲載種別：書評論文，書評，文献紹介等  

Ameloblastomas and keratocystic odontogenic tumors (KCOT) are typical jawbone tumors. In addition, dentigerous cysts (DC) and radicular cysts are the most common cystic jawbone lesions, and simple bone cysts (SBC) are the most common jawbone pseudocysts. When these lesions are unilocular, it can be difficult to diagnose them by radiography. In recent years, adding magnetic resonance (MR) imaging to obtain information about soft tissue has been shown to improve the accuracy of jawbone lesion diagnosis. We also have reported MR imaging features of jawbone lesions. However, no systematic method for MR imaging diagnosis of jawbone lesions has been reported. In this review, we examine unilocular lesions such as ameloblastoma, KCOT, adenomatoid odontogenic tumour (AOT), DC, and SBC. First, we describe the MR imaging features of each lesion. Then, we describe our novel MR imaging diagnostic protocol. Using our MR imaging diagnostic protocol to diagnose 31 cases, we obtained a positivity rate of 71.0%. The use of our MR imaging diagnostic protocol for unilocular lesions, which are especially difficult to differentiate by radiography, would improve the morphological and qualitative diagnosis of soft tissue lesions. © 2012 Japanese Association for Dental Science.

DOI： 10.1016/j.jdsr.2012.01.001

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記述言語：英語   出版者・発行元：OKAYAMA UNIV MED SCHOOL  

The roles of cell density, extracellular space, intracellular factors, and apoptosis induced by the molecularly targeted drug rituximab on the apparent diffusion coefficient (ADC) values were investigated using bio-phantoms. In these bio-phantoms, Ramos cells (a human Burkitt's lymphoma cell line) were encapsulated in gellan gum. The ADC values decreased linearly with the increase in cell density, and declined steeply when the extracellular space became less than 4 gm. The analysis of ADC values after destruction of the cellular membrane by sonication indicated that approximately 65% of the ADC values of normal cells originate from the cell structures made of membranes and that the remaining 35% originate from intracellular components. Microparticles, defined as particles smaller than the normal cells, increased in number after rituximab treatments, migrated to the extracellular space and significantly decreased the ADC values of bio-phantoms during apoptosis. An in vitro study using bio-phantoms was conducted to quantitatively clarify the roles of cellular factors and of extracellular space in determining the ADC values yielded by tumor cells and the mechanism by which apoptosis changes those values.

DOI： 10.18926/AMO/48566

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記述言語：英語   出版者・発行元：ELSEVIER SCIENCE INC  

Odontogenic fibroma (OF) is a rare nonepithelial benign tumor arising from the odontogenic mesenchymal tissue in the jawbone. OFs are topographically categorized into 2 types, the central type and peripheral type, and are histopathologically divided into the epithelium-poor type and epithelium-rich type. The radiological findings of central OF commonly include a uni- or multilocular radiolucent area with a well-defined margin, which are similar to those of cysts and other benign tumors of the jawbone. Therefore, it is difficult to distinguish OF from these jawbone lesions on radiographs because of their noncharacteristic radiological findings. In this article, we report the cases of 2 patients with central OF who underwent magnetic resonance (MR) examinations and describe the usefulness of dynamic contrast-enhanced MR imaging for diagnosing OF. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:e51-e58)

DOI： 10.1016/j.oooo.2011.12.013

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記述言語：英語   出版者・発行元：SPRINGER HEIDELBERG  

This study evaluated the test-retest reliability for determining the temporomandibular joint (TMJ) disk position, diagnosed using magnetic resonance imaging (MRI). These assessments were done as a base-line measurement for a prospective cohort study, which examines the risk factors for precipitation and progression of temporomandibular disorders. Fifteen subjects (mean age, 24.2 +/- 0.94 years; male/female = 8/7) were recruited from the students of Okayama University Dental School. Sagittal MR TMJ images were taken with a 1.5-T MR scanner (Magneton Vision, Siemens) in close and maximal open positions twice at about 1-week (6-11 days) interval. The images were displayed using 200% magnification on a computer screen with a commercially available image software package (OSIRIS, UIN/HCUG). Three calibrated examiners diagnosed the disk positions using the standardized criteria. The disk position of each joint was classified as normal, anterior disk displacement with or without reduction, and others. The first and second disk position diagnoses were compared, and the test-retest reliability level was calculated using the kappa index. The second disk position diagnosis was consistent with the first in 27 out of 30 joints. The calculated kappa value representing the test-retest reliability level between the first and second disk position diagnosis was 0.812. These results indicated that the test-retest reliability of MRI-based diagnosis of TMJ disk positions at about 1-week interval was substantially high, even though they were not completely consistent.

DOI： 10.1007/s00784-010-0476-9

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

J-GLOBAL

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記述言語：英語   出版者・発行元：ELSEVIER SCIENCE INC  

Objective. High-dose-rate (HDR) brachytherapy using a customized mold is a minimally invasive treatment for oral cancer; however, it is difficult to use this technique for buccal and lip cancers involving the commissura labiorum, owing to its anatomic form. The purpose of this study was to introduce an improved customized mold consisting of 2 pieces to allow the fixation of molds to these sites.
Study design. Five patients with buccal carcinoma and 1 patient with lip carcinoma were treated with this technique after external beam radiotherapy. One patient with neck metastasis underwent both neck dissection and partial tumor resection before HDR brachytherapy.
Results. At the end of the follow-up period, 5 patients had no tumor recurrence, and 1 patient had suffered local recurrence.
Conclusions. Our technique is a viable therapeutic option for patients with buccal and lip carcinomas for whom the therapeutic modalities are limited by age, performance status, and other factors. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:118-125)

DOI： 10.1016/j.tripleo.2011.06.038

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記述言語：英語   出版者・発行元：ELSEVIER SCIENCE BV  

The activity of the lateral pterygoid muscle has been regarded to be related to the pathological condition of the temporomandibular joint (TMJ) in the craniomandibular disorders. Because the lateral pterygoid muscle is a deep muscle, a needle electrode is necessary for EMG recordings. The purpose of this study was to establish a non-invasive method for the evaluation of muscle activity of the lateral pterygoid muscle using mechanomyogram (MMG). In three male subjects, surface electromyogram (EMG) in the left masseter muscle, left anterior and posterior belly of the temporal muscle, left anterior belly of the digastric muscle and needle EMG of the inferior head of the lateral pterygoid were recorded during mandibular movement tasks simultaneously with the MMG derived from a condenser microphone in the external ear canal. There were significant positive correlations between the needle EMG signal of the lateral pterygoid muscle and the MMG signal for the tasks of static jaw opened position of 30 mm of interincisal distance (p = 0.000, R(2)=0.725), static jaw opened position of 40 mm of interincisal distance (p = 0.000, R(2) = 0.753), 5 mm protruded mandibular position (p = 0.000, R(2) = 0.653), the most protruded mandibular position (p = 0.000, R(2) = 0803). On the contrary, for the task of maximal clenching, there was no significant correlation between the EMG signal of the lateral pterygoid muscle and the MMG signal. These results suggest that the activity of the lateral pterygoid muscle could be evaluated by the MMG signals recorded in the external ear canal, unless jaw closing major muscles show active contraction. (C) 2011 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jneumeth.2011.09.026

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記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

「歯科放射線学分野」の講義試験としてe-learning(WebClassシステム)によるPCを用いた試験を試み、受験生56名に試験後アンケート調査を行ってその有用性について検討した。肯定的回答(大変そう思う・そう思う)の割合は、PC使用試験については「共用試験CBTの予行として役立つ」100%、「試験解説がすぐに受けられる」93%、「試験結果がすぐに公表される」78%で、低かったのは「試験に集中しやすい」46%、「システムの使用が難しい」49%であった。試験会場については「席による不公平がない」91%、「講義室からの移動が面倒」71%であった。視覚素材については、「あると問題が理解しやすい」96%、「問題が難しくなる」52%であった。試験内容(選択問題)については、「国家試験、CBTの予行になる」「採点結果が明確」100%、「理解度をアピールしにくい」72%、「楽だ」35%、「語彙力、理解力低下につながる」47%であった。共用試験CBT後のアンケートではPC使用試験が「予行として役立った」98%であった。

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Malignant lymphoma is the second-most common malignancy in the head and neck region. Waldeyer&apos;s ring is the most common site of extranodal Hodgkin&apos;s lymphoma (NHL) in that region, and a small percentage of primary extranodal NHL occurs in the oral cavity. The most common sites of extranodal NHL in the oral region are the palate and maxilla, and nearly half of extranodal NHL cases arise from bone. It is difficult to diagnose extranodal NHL because of the variety of its radiological features. We report a case of primary extranodal NHL of the maxilla in a 68-year-old female patient with atypical imaging findings, along with the results of analysis of dynamic magnetic resonance imaging (MRI). (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e59-e69)

DOI： 10.1016/j.tripleo.2011.02.052

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記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Ameloblastic carcinoma is a rare malignant odontogenic carcinoma that has metastatic potential, and because of its rare incidence, there are few reports focusing on its radiologic imaging. If it shows aggressive appearances, it can be diagnosed as malignant tumor. But in case of negative appearance, it is difficult to distinguish ameloblastic carcinoma from ameloblastoma. We report a case of ameloblastic carcinoma of the maxilla in a 76-year-old female patient with radiologic images and pathologic features. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e40-e47)

DOI： 10.1016/j.tripleo.2011.01.023

Web of Science

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記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）   出版者・発行元：(NPO)日本口腔科学会  

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