2021/07/12 更新

写真a

アサウミ ジュンイチ
浅海 淳一
ASAUMI Junichi
所属
医歯薬学域 教授
職名
教授
外部リンク

学位

  • 医学博士 ( 岡山大学 )

研究キーワード

  • oral cancer

  • radiation oncology

  • oral radiology

  • 歯科放射線学

  • hyperthermia

  • chemotherapy

研究分野

  • ライフサイエンス / 病態系口腔科学

学歴

  • 広島大学   Faculty of Dentistry  

    - 1984年

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  • 広島大学   歯学部   歯学科

    - 1984年

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    国名: 日本国

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経歴

  • - 岡山大学岡山大学病院岡山大学病院口腔検査・診断センター センター長

    2013年

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  • - Foreign visiting Professor, Faculty of Dentistry of Ribeirão Preto, University of São Paulo (FORP) Research Center Foreign visiting Professor, UNIVERSIDADE DE SÃO PAULO - 教授

    2013年

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  • FACULDADE DE ODONTOLOGIA COMISSÃO COORDENADORA DE PROGRAMA DIAGNÓSTICO BUCAL 教授

    2013年

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  • - 広島大学非常勤講師 講師

    2013年

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  • - 岡山大学岡山大学病院岡山大学病院頭頸部がんセンター 副センター長

    2012年

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  • - 岡山大学医歯薬学総合研究科岡山大学医歯薬学総合研究科 副研究科長

    2012年

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  • - 岡山大学医歯薬学総合研究科岡山大学大学院医歯薬学総合研究科産学官連携イノベーションセンターOMIC事業推進協力教員(併任教授)産学官連携センター 教授

    2010年

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  • - 岡山大学岡山大学病院総合診断室 室長

    2010年

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  • a foreign visiting Professor, UNIVERSIDADE DE SÃO PAULO FACULDADE DE ODONTOLOGIA POSTGRADUATE PROGRAM IN DENTISTRY Area: Buccal Diagnosis 教授

    2009年 - 2019年

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  • - 独立行政法人理化学研究所 分子イメージング科学研究センター メタロミクスイメージング研究ユニット 客員研究員 研究員

    2009年

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  • - 岡山大学医歯薬学総合研究科病態制御科学専攻歯科放射線学分野 教授

    2008年

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  • University of Minnesota Medical School Visiting Assistant Professor 教授

    2004年

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  • 岡山大学歯学部歯学科岡山大学講師(医学部・)歯学部附属病院(歯科放射線・口腔診断科) 講師   School of Dentistry, Dental School

    2001年 - 2008年

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  • 放射線医学研究所共同利用研究員(第 3研究グループ) 研究員

    1998年 - 2001年

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  • 岡山大学歯学部歯学科岡山大学助手(歯科放射線学講座) 助手   School of Dentistry, Dental School

    1997年 - 2000年

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  • 国立岡山病院歯科・口腔外科 厚生技官 職員(医療系)

    1994年 - 1997年

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  • 香川医科大学

    1994年 - 1996年

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  • 岡山大学歯学部歯学科岡山大学助手歯学部(口腔外科学第1講座) 助手   School of Dentistry, Dental School

    1993年

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  • 水島第一病院歯科医師(岡山県) 職員(医療系)

    1990年 - 1993年

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  • 岡山大学歯学部歯学科岡山大学助手歯学部(口腔外科学第1講座) 助手   School of Dentistry, Dental School

    1989年 - 1990年

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  • 岡山大学歯学部歯学科岡山大学助手歯学部附属病院(第一口腔外科) 助手   School of Dentistry, Dental School

    1988年

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  • 光輝病院歯科・口腔外科科長(山口県) 職員(医療系)

    1986年 - 1988年

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  • 岡山大学歯学部歯学科岡山大学助手歯学部附属病院(総合診療室) 助手   School of Dentistry, Dental School

    1986年

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  • 西条中央病院歯科医師(愛媛県) 職員(医療系)

    1985年

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所属学協会

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委員歴

  • 日本歯科放射線学会   第52回関西地方会・第48回九州地方会 大会長  

    2009年   

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    団体区分:学協会

    日本歯科放射線学会

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  • 日本口腔科学会   評議員  

    2009年   

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    団体区分:学協会

    日本口腔科学会

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  • 日本口腔診断学会   理事  

    2008年   

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    団体区分:学協会

    日本口腔診断学会

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  • 岡山歯学会   理事  

    2008年   

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    団体区分:学協会

    岡山歯学会

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  • 日本歯科放射線学会   教育委員会委員  

    2008年   

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    団体区分:学協会

    日本歯科放射線学会

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  • 日本口腔診断学会   学術委員  

    2007年   

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    団体区分:学協会

    日本口腔診断学会

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  • 日本歯科放射線学会   認定委員  

    2006年   

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    団体区分:学協会

    日本歯科放射線学会

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  • 日本歯科放射線学会   広報委員  

    2006年   

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    団体区分:学協会

    日本歯科放射線学会

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  • 日本歯科放射線学会   英文編集委員  

    2006年   

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    団体区分:学協会

    日本歯科放射線学会

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  • 日本歯科放射線学会   理事  

    2006年   

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    団体区分:学協会

    日本歯科放射線学会

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書籍等出版物

  • Atlas de IRM em Diagnóstico Oral e Maxilofacial: Princípio e Aplicação emodontologia.

    Elsevier, Rio de Janeiro  2015年  ( ISBN:9788535283

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  • Perfusion imaging in maxillofacial lesions.

    Wolters Kluwer Health  2015年  ( ISBN:1451193165

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  • Computed Tomography: New Research

    Nova Science Publishers Inc.  2013年 

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  • 第5版 歯科放射線学.

    医歯薬出版株式会社  2013年 

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  • Computed Tomography: New Research.

    Nova Science Publishers Inc.  2013年 

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  • Computed Tomography: New Research.

    Nova Science Publishers Inc.  2013年 

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  • Computed Tomography: New Research

    Nova Science Publishers Inc.  2013年 

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  • Role of O6-methyl guanine-DNA methyl transferase and the effect of O6- benzylguanine in cancer chemotherapy. In:Encyclopedia of Cancer Treatment (2 Volume Set).

    Nova Science Publishers  2012年 

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  • Recent Advances in the diagnostic imaging of cysts and pseudocysts in the oral and maxillofacial region. In: Cysts: Causes, Dignosis and Treatment Options.

    Nova Science Publisher  2012年 

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  • hTERT in cancer chemotherapy: A novel target of histone deacetylase inhibitors. In: Encyclopedia of DNA Research (3 Volume Set).

    Nova Science Publishers  2012年 

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  • 一歩先のパノラマ診断力.

    砂書房  2012年 

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  • Radiotherapy for Oral Cancer, Oral Cancer:

    Nova Science Publishers  2011年 

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  • Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Head and Neck Tumors.

    Nova Science Publishers  2011年 

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  • Role of O6-methyl guanine-DNA methyl transferase and the effect of O6-benzylguanine in cancer chemotherapy.

    Nova Science Publishers  2009年 

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  • 歯科臨床における画像診断アトラス

    医歯薬出版,東京  2008年 

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  • Progress in Oral Cancer Research

    Nova Science Publishers,NY  2008年 

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  • 歯科臨床における画像診断アトラス

    医歯薬出版,東京  2008年 

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  • 歯科臨床における画像診断アトラス

    医歯薬出版,東京  2008年 

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  • 歯科臨床における画像診断アトラス

    医歯薬出版,東京  2008年 

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  • The 10th Workshop on Optimization and Inverse Problems in Electromagnetism

    2008年 

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  • 歯科臨床における画像診断アトラス

    医歯薬出版,東京  2008年 

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  • Gene therapy in cancer

    Nova Science Publishers  2005年 

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  • Recent aspects of elucidating the cellular basis of thermochemotherapy (jointly worked)

    Thermotherapy for Neoplasia, Inflammation, and Pain Springer-Verlag Tokyo Berlin Heiderberg New York  2001年 

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  • Thermotherapy for Neoplasia, Inflammation, and Pain

    Springer-Verlag Tokyo Berlin Heiderberg New York  2001年 

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MISC

  • A case of sublingual adenoid cystic carcinoma involving the mandible presenting as a “skip lesion”

    Mariko Fujita, Yoshinobu Yanagi, Arthur, R.G. Cortes, Emiko Saito Arita, Tomoo Onoda, Hitoshi Nagatsuka, un ichi Asaumi

    Oral Radiology   1 - 7   2017年11月

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  • Benign Miliary Osteoma Cutis of the Face: A Common Incidental CT Finding

    D. Kim, G. A. Franco, H. Shigehara, J. Asaumi, P. Hildenbrand

    AMERICAN JOURNAL OF NEURORADIOLOGY   38 ( 4 )   789 - 794   2017年4月

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    記述言語:英語   出版者・発行元:AMER SOC NEURORADIOLOGY  

    BACKGROUND AND PURPOSE: Osteoma cutis of the face represents a primary or secondary formation of ossific foci in the facial skin. Its primary form has been sparsely described in the plastic surgery and dermatology literature. As radiologists, we routinely encounter incidental, very small facial calcified nodules on CT studies performed for a variety of unrelated reasons. We hypothesized that this routinely encountered facial calcification represents primary miliary osteoma cutis and is a common, benign, age-related finding.
    MATERIALS AND METHODS: We retrospectively reviewed 1315 consecutive sinus CTs obtained during an 8-month period and their associated demographics. The number of dermal radiopaque lesions with Hounsfield units of >150 was counted, and we analyzed the association between the prevalence of these lesions and patients' demographics with logistic regression methods.
    RESULTS: Five hundred ninety-nine males and 716 females from 4 to 90 years of age were included in the study (mean, 52 versus 51 years; P =.259). Among these, 252 males and 301 females had small facial calcified nodules (42.1% versus 42.0%, P =.971). The patient's age was a statistically significant predictor for having facial calcified nodules (odds ratio = 1.02, P <.001), while the patient's sex was not (P =.826).
    CONCLUSIONS: Facial calcified nodules, observed in routine head and face CT imaging, are common, benign, age-related findings, which have been largely overlooked in the radiology literature. It is a manifestation of primary miliary osteoma cutis.

    DOI: 10.3174/ajnr.A5096

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  • De novo myoepithelial carcinoma with multiple metastases arising from a submandibular salivary gland: A case report

    Karina Cecilia Panelli Santos, Hidenobu Matsuzaki, Teruhisa Unetsubo, Shimo Tsuyoshi, Hitoshi Nagatsuka, Jun-Ichi Asaumi

    ONCOLOGY LETTERS   13 ( 4 )   2679 - 2683   2017年4月

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    記述言語:英語   出版者・発行元:SPANDIDOS PUBL LTD  

    Salivary gland carcinomas are rare tumors, representing similar to 0.5% of all malignancies. Myoepithelioma is also uncommon, representing similar to 1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases arising from a submandibular gland in a 71-year-old male patient and present the associated imaging findings. The patient was considered to have a de novo type of myoepithelial carcinoma, which is reportedly associated with higher malignancy than the transformation type of the disease (i.e., a malignant change from pleomorphic adenoma or myoepithelioma). This was reflected in the multiple lung and bone metastases sites and strong positivity for p53 and Ki-67.

    DOI: 10.3892/ol.2017.5783

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  • Current status of oral and maxillofacial radiology in West Africa

    Babatunde O, Bamgbose,Muhammad, A. Suwaid, Mohammad Abubakar Kaura, Irfan Sugianto, Miki Hisatomi, Junichi Asaumi

    Oral Radiology   1 - 8   2017年

  • Should incidental findings in diagnostic imaging be reported?

    Karina C, Panelli Santos, Mariko Fujita, Jefferson X. Oliveira, Yoshinobu Yanagi, Junichi Asaumi

    Minerva Stomatologica   66 ( 2 )   75 - 80   2017年

  • Parotid mandibular bone defect

    Miki Hisatomi, Luciana Munhoz, Junichi Asaumi, Emiko Saito Arita

    Imaging Science in Dentistry   47 ( 4 )   269 - 273   2017年

  • Review articles required for inclusion in Index Medicus and Medline

    Junichi Asaumi

    ORAL RADIOLOGY   32 ( 2 )   71 - 71   2016年5月

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    記述言語:英語   出版者・発行元:SPRINGER  

    DOI: 10.1007/s11282-016-0244-x

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  • Comparison of the diagnostic performance of panoramic and occlusal radiographs in detecting submandibular sialoliths

    Jun Ho Kim, Eduardo Massaharu Aoki, Arthur Rodriguez Gonzalez Cortes, Reinaldo Abdala-Júnior, Junichi Asaumi, Emiko Saito Arita

    Imaging Science in Dentistry   46 ( 2 )   87 - 92   2016年

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    記述言語:英語   出版者・発行元:Korean Academy of Oral and Maxillofacial Radiology  

    Purpose: The aim of this study was to assess and compare the diagnostic performance of panoramic and occlusal radiographs in detecting submandibular sialoliths. Materials and Methods: A total of 40 patients (20 cases and 20 controls) were included in this retrospective study. Cases were defined as subjects with a submandibular sialolith confirmed by computed tomography (CT), whereas controls did not have any submandibular calcifications. Three observers with different expertise levels assessed panoramic and occlusal radiographs of all subjects for the presence of sialoliths. Intraobserver and interobserver agreement were assessed using the kappa test. Sensitivity, specificity, accuracy, positive and negative predictive values, and the diagnostic odds ratio of panoramic and occlusal radiographs in screening for submandibular sialoliths were calculated for each observer. Results: The sensitivity and specificity values for occlusal and panoramic radiographs all ranged from 80% to 100%. The lowest values of sensitivity and specificity observed among the observers were 82.6% and 80%, respectively (P=0.001). Intraobserver and interobserver agreement were higher for occlusal radiographs than for panoramic radiographs, although panoramic radiographs demonstrated a higher overall accuracy. Conclusion: Both panoramic and occlusal radiographic techniques displayed satisfactory diagnostic performance and should be considered before using a CT scan to detect submandibular sialoliths.

    DOI: 10.5624/isd.2016.46.2.87

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  • 口腔外科・歯科領域の画像診断 放射線科医の日常臨床に役立つ知識 下顎の嚢胞性病変.

    臨床画像   31 ( 7 )   819 - 833   2016年

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  • High-dose-rate brachytherapy using molds for lip and oral cavity tumors

    Teruhisa Unetsubo, Hidenobu Matsuzaki, Mitsuhiro Takemoto, Kuniaki Katsui, Marina Hara, Norihisa Katayama, Takahiro Waki, Susumu Kanazawa, Jun-ichi Asaumi

    RADIATION ONCOLOGY   10 ( 1 )   81   2015年4月

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    記述言語:英語   出版者・発行元:BIOMED CENTRAL LTD  

    Background: High-dose-rate (HDR) brachytherapy using the mold technique is a less invasive treatment for early lip and oral cavity cancer. However, limited reports exist regarding the feasibility of this method. In this retrospective study, we evaluated the outcome of this therapy and investigated its feasibility for lip and oral cavity tumors.
    Methods: Between May 2002 and December 2010, 17 patients (median age, 80.0 years) with histologically confirmed squamous cell carcinoma of the lip or oral cavity were treated by means of HDR brachytherapy using the mold technique after external beam radiotherapy (EBRT). Tumor sites included the buccal mucosa in eight cases, the gingiva in three cases, the lips in two cases, the floor of the mouth in two cases, and the hard palate in two cases. For all patients, EBRT (30 Gy/15 fractions), was performed before HDR brachytherapy. Two 6-Gy fractions were delivered twice daily for 2 days a week with an interval of 6 hours between the fractions. The total HDR brachytherapy dose was 24 Gy. Prior to EBRT, two patients with neck metastasis underwent neck dissection, and one patient with an exophytic tumor underwent tumor resection.
    Results: The median follow-up period was 53.4 (range, 4.8-83.4) months. Of the 17 patients, 14 (82.4%) achieved a complete response, and three (17.6%) displayed a partial response. The overall 3-and 5-year survival rates were both 68.8%, the 3-and 5-year disease-specific survival rates were both 86.7%, and the 3-and 5-year local control rates were both 54.1%. Seven patients developed local recurrence at a median time of 3.4 (range, 1.7-29.1) months after treatment. Nodal and lung metastases occurred separately in two patients. By the end of the follow-up period, two patients had died of the primary disease and four patients had died of other causes.
    Conclusions: Although there is a need to improve the technical aspects of the treatment protocol, HDR brachytherapy using the mold technique might be a therapeutic option for superficial lip or oral cavity tumors, especially in older patients who have a poor performance status or are in poor physical condition.

    DOI: 10.1186/s13014-015-0390-z

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  • Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report

    Shintaro Sukegawa, Hidenobu Matsuzaki, Naoki Katase, Takahiro Kanno, Toshiko Mandai, Yuka Takahashi, Jun-Ichi Asaumi, Yoshihiko Furuki

    ONCOLOGY LETTERS   9 ( 1 )   131 - 135   2015年1月

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    記述言語:英語   出版者・発行元:SPANDIDOS PUBL LTD  

    Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare type of odontogenic carcinoma arising from the jawbone. Odontogenic cysts are true cysts that arise from the dental epithelium, which is associated with tooth formation. The epithelial lining of odontogenic cysts has the potential to transform into various types of odontogenic tumor; however, this transformation from an odontogenic cyst to a malignant tumor is rare. The definitive diagnosis for PIOSCC generally requires the observation of either features of squamous cell carcinoma (SCC) within the jawbone that are distinct from direct invasion from the surface oral epithelium, or evidence of SCC arising from odontogenic epithelium and from tumors that have metastasized to the jawbone from distant sites. In the present study, a case of PIOSCC of the maxilla is presented, which, based on the results of computed tomography and the clinical course, was hypothesized to have originated from an infected residual cyst.

    DOI: 10.3892/ol.2014.2644

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  • A new phantom and empirical formula for apparent diffusion coefficient measurement by a 3 Tesla magnetic resonance imaging scanner

    Marina Hara, Masahiro Kuroda, Yuichi Ohmura, Hidenobu Matsuzaki, Tomoki Kobayashi, Jun Murakami, Kazunori Katashima, Masakazu Ashida, Seiichiro Ohno, Jun-Ichi Asaumi

    ONCOLOGY LETTERS   8 ( 2 )   819 - 824   2014年8月

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    記述言語:英語   出版者・発行元:SPANDIDOS PUBL LTD  

    The aim of this study was to create a new phantom for a 3 Tesla (3T) magnetic resonance imaging (MRI) device for the calculation of the apparent diffusion coefficient (ADC) using diffusion-weighted imaging (DWI), and to mimic the ADC values of normal and tumor tissues at various temperatures, including the physiological body temperature of 37 C. The phantom was produced using several concentrations of sucrose from 0 to 1.2 M, and the DWI was performed using various phantom temperatures. The accurate ADC values were calculated using the DWIs of the phantoms, and an empirical formula was developed to calculate the ADC values of the phantoms from an arbitrary sucrose concentration and arbitrary phantom temperature. The empirical formula was able to produce ADC values ranging between 0.33 and 3.02x10(-3) mm(2)/sec, which covered the range of ADC values of the human body that have been measured clinically by 3T MRI in previous studies. The phantom and empirical formula developed in this study may be available to mimic the ADC values of the clinical human lesion by 3T MRI.

    DOI: 10.3892/ol.2014.2187

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  • Diagnostic value of MR imaging for dentigerous cysts

    Hironobu Konouchi, Jun-ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Emiko Saito Arita, Plauto Christopher Aranha Watanabe, Jun Murakami, Teruhisa Unetsubo, Mariko Fujita, Shunsuke Okada, Hidenobu Matsuzaki, Toshihiko Takenobu, Toru Wakasa

    ORAL RADIOLOGY   30 ( 1 )   13 - 19   2014年1月

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    記述言語:英語   出版者・発行元:SPRINGER  

    It is known that the magnetic resonance (MR) imaging features of dentigerous cysts (DCs) are the same as those of other cysts. The cavities of DCs generally show low signal intensity (SI) on T1-weighted imaging (T1WI). However, in our experience, DCs often show high SI on T1WI, rendering them difficult to distinguish from keratocystic odontogenic tumors (KCOTs). In this study, we evaluated seven cases of DC and 23 cases of KCOT to assess whether MR imaging can provide additional information for the differential diagnosis of DC and KCOT.Two trials were evaluated. The first trial was an analysis of the cystic cavity SI on T1WI. To compare the SI between patients, we performed T1WI with contrast (T1c). The second trial analyzed the SI uniformity (U (I )) pound on T1WI, T2-weighted imaging (T2WI), and short inversion time inversion recovery (STIR) images of the cystic cavity, because it has been reported that an MR imaging feature of KCOT is heterogeneous SI. Statistical analyses were performed using the Mann-Whitney U test and a receiver operating characteristic (ROC) curve.The T1c values of DCs were significantly higher than those for KCOTs. The U (I ) pound values on T1WI and STIR images were significantly higher for DCs than for KCOTs. The T1c cutoff values (0.66 and 0.84) and U (I ) pound cutoff values for T1WI (82.1 %) and STIR images (79.8 %) were determined from the ROC analyses.T1c and U (I ) pound values provide useful additional information for the differential diagnosis of DC and KCOT.

    DOI: 10.1007/s11282-013-0128-2

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  • Fibrous dysplasia of the maxilla: a case report together with its conventional imaging and dynamic magnetic resonance imaging findings

    Marina Hara, Hidenobu Matsuzaki, Naoki Katase, Teruhisa Unetsubo, Yoshinobu Yanagi, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL RADIOLOGY   30 ( 1 )   105 - 110   2014年1月

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    記述言語:英語   出版者・発行元:SPRINGER  

    We previously reported that dynamic contrast-enhanced MRI parameters and time-signal intensity curves (TICs; also known as contrast index curves) are useful for the differential diagnosis of jawbone lesions. In particular, odontogenic fibroma and ossifying fibroma, which possess similar histopathological features (i.e., a mixture of hard and soft tissue components), display unique TIC patterns, and we consider that the TIC patterns of these lesions reflect their hard and soft tissue components. Therefore, fibrous dysplasia, which contains fibrous tissue and immature isolated trabeculae composed of woven bone, is expected to display an interesting TIC. The purpose of this study was to assess the utility of TICs for differentiating between the abovementioned lesions, which have similar histopathological components.

    DOI: 10.1007/s11282-013-0137-1

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  • Evaluation of basilar expansion and internal septa of human sphenoidal sinus using cone beam computed tomography.

    Marcio Yara Buscatti, Karina Cecília, Panelli Santos, Emiko Saito Arita, Junichi Asaumi, Plauto Christopher Aranha Watanabe, Jefferson Xavier, Oliveira

    Clin Lab Res Den   20 ( 3 )   166   2014年

  • Case series: conditions inhibiting eruption of permanent first molars.

    Matsuzaki H, Yanagi Y, Katase N, Nagatsuka H, Hara M, Ashida M, Unetsubo T, Sato A, Fujita M, Takenobu T, Asaumi J

    Pediatr Dent.   35 ( 1 )   67 - 70   2014年

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  • 下顎骨筋突起による介達骨折と考えた上顎洞後壁、眼窩下壁骨折の1例

    日本口腔顎顔面外傷学会誌,   13 ( 1 )   22 - 27   2014年

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  • Improved longitudinal length accuracy of gross tumor volume delineation with diffusion weighted magnetic resonance imaging for esophageal squamous cell carcinoma.

    Hou DL, Shi GF, Gao XS, Asaumi J, Li XY, Liu H, Yao C, Chang JY

    Radiat Oncol.   8 ( 1 )   169   2014年

  • Audience Response System(クリッカー)の活用による「歯科放射線学」における参加型講義の評価.

    此内浩信, 柳 文修, 久富美紀, 畦坪輝寿, 村上 純, 藤田麻里子, 竹信俊彦, 若狭 亨, 岡田俊輔, 浅海淳一

    岡山歯学会雑誌   32 ( 1 )   1 - 8   2014年

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  • Diagnostic value of MRI for odontogenic tumours.

    Fujita M, Matsuzaki H, Yanagi Y, Hara M, Katase N, Hisatomi M, Unetsubo T, Konouchi H, Nagatsuka H, Asaumi JI

    Dentomaxillofac Radiol.   42 ( 5 )   20120265   2014年

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  • Optimal contouring of seminal vesicle for definitive radiotherapy of localized prostate cancer: comparison between EORTC prostate cancer radiotherapy guideline, RTOG0815 protocol and actual anatomy.

    Qi X, Gao XS, Asaumi J, Zhang M, Li HZ, Ma MW, Zhao B, Li FY, Wang D

    Radiat Oncol.   20 ( 9 )   288   2014年

  • Swelling of the floor of the mouth in an infant

    Hidenobu Matsuzaki, Naoki Katase, Norifumi Moritani, Marina Hara, Yoshinobu Yanagi, Jun-Ichi Asaumi

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   116 ( 4 )   392 - 397   2013年10月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    DOI: 10.1016/j.oooo.2012.03.025

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  • A modified Phase I trial of radiation dose escalation in 3D conformal radiation therapy with concurrent vinorelbine and carboplatin chemotherapy for non-small-cell lung cancer

    Qiang Lin, Yue'e Liu, Na Wang, Yuehua Huang, Xiaohui Ge, Xiaocang Ren, Xueji Chen, Jing Hu, Zhijun Guo, Yannan Zhao, Junichi Asaumi

    JOURNAL OF RADIATION RESEARCH   54 ( 1 )   126 - 134   2013年1月

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    記述言語:英語   出版者・発行元:OXFORD UNIV PRESS  

    The Radiation Therapy Oncology Group reported a maximum tolerated dose of 74 Gy for patients with non-small cell lung cancer (NSCLC); however, it was unclear whether this dose could be safely administered to Asian patients due to differences in their physique compared to Western patients. We therefore conducted a modified Phase I trial to determine whether 70 Gy could be safely delivered to Chinese patients with NSCLC undergoing 3D-conformal radiation therapy (3D-CRT) with concurrent chemotherapy. Previously untreated NSCLC patients received 3D-CRT (2 Gy/day, 5 fractions per week). Three dose levels were examined: 62, 66 and 70 Gy. Two cycles of concurrent chemotherapy (vinorelbine and carboplatin) were started on the first day of radiation therapy. Dose-limiting toxicity (DLT) was defined as severe or life-threatening side effects that altered the continued implementation of chemoradiotherapy. Among the 19 patients recruited in this study, most of the haematologic and non-haematologic toxicities were mild to moderate and clinically manageable. Only one patient, in the 70 Gy cohort, experienced a DLT of Grade 3 radiation-induced pneumonia. The overall response rate was 77.8% (14/18). The median progression-free survival (PFS) was 12 months, and the 1-year PFS was 37.6%. Our results support both the feasibility of incorporating 3D-CRT with concurrent vinorelbine and carboplatin and a dose escalation to 70 Gy for Chinese patients with NSCLC, based on the acceptable toxicity and encouraging overall response and survival rates. A further evaluation of this regimen in a prospective Phase II trial is ongoing.

    DOI: 10.1093/jrr/rrs081

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  • In vitro assessment of factors afecting the apparent difusion coefcient of jurkat cells using bio-phantoms

    Kazunori Katashima, Masahiro Kuroda, Masakazu Ashida, Takanori Sasaki, Takehito Taguchi, Hidenobu Matsuzaki, Jun Murakami, Yoshinobu Yanagi Hisatomi, Marina Hara, Hirokazu Kato, Yuichi Ohmura, Tomoki Kobayashi, Susumu Kanazawa, Sosuke Harada, Mitsuhiro Takemoto, Seiichiro Ohno, Seiichi Mimura, Junichi Asaumi

    Acta Medica Okayama   67 ( 6 )   359 - 367   2013年

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    記述言語:英語  

    It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30 sec. Heating at 42° C was used to induce apoptosis while heating at 48°C was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3/um. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30 msec might be optimal to distinguish between apoptosis and necrosis.

    DOI: 10.18926/AMO/52009

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  • Diagnostic value of dynamic contrast-enhanced MRI for submucosal palatal tumors

    Hidenobu Matsuzaki, Yoshinobu Yanagi, Marina Hara, Naoki Katase, Miki Hisatomi, Teruhisa Unetsubo, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka, Jun-ichi Asaumi

    EUROPEAN JOURNAL OF RADIOLOGY   81 ( 11 )   3306 - 3312   2012年11月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    Objectives: To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) for differentiating between benign and malignant tumors in the palate.
    Materials and methods: 26 patients with submucosal palatal tumors were preoperatively examined using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), and washout ratios (WR300 and WR600) were determined from contrast index curves. The submucosal palatal tumors were divided into two groups according to their Tmax values: the early enhancement group (Tmax < 300 s) consisted of 9 malignant tumors and 6 benign tumors, while the late enhancement group (Tmax >= 300 s) included one malignant tumor and 10 benign tumors. We compared the following DCE-MRI parameters between the benign and malignant tumors: CImax and Tmax in all cases and CImax, Tmax, and the washout ratios in the early enhancement group. In addition, we performed a regression analysis of the relationships between tumor size and DCE-MRI parameters; i. e., CImax, Tmax, and washout ratios, among the malignant salivary gland tumors and pleomorphic adenomas.
    Results: In all cases and the early enhancement group, significant differences in Tmax were detected between the benign and malignant tumors (P < 0.001 and P < 0.05, respectively), and the optimal Tmax cutoff value for differentiating between them was found to be 165 s. None of the other parameters displayed significant differences between the benign and malignant tumors. Only the WR600 of the pleomorphic adenomas was significantly correlated with tumor size (R-2 = 0.92, P < 0.001).
    Conclusions: Tmax is a useful parameter for distinguishing between benign and malignant submucosal palatal tumors. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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  • Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings

    Marina Hara, Hidenobu Matsuzaki, Naoki Katase, Yoshinobu Yanagi, Teruhisa Unetsubo, Jun-ichi Asaumi, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   114 ( 4 )   E139 - E146   2012年10月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Ossifying fibroma (OF), a rare nonodontogenic tumor, is defined as a bone-related jawbone lesion. The main histopathological feature of OF is the replacement of bone by benign connective tissue. Ossifying fibroma usually occurs in the second to fourth decades of life and shows a predilection for females. Ossifying fibroma most commonly occurs in the mandible, and OF arising from the anterior part of the maxilla is rare. Ossifying fibromas display various radiographic findings, including varying degrees of radiolucency and radiopacity, depending on the proportions of their soft and hard tissue components. Depending on their components, it can be difficult to distinguish OF from other fibroosseous lesions and some odontogenic tumors by using conventional radiographs, computed tomography, and magnetic resonance imaging (MRI). We report a case of OF in the anterior maxilla in a 56-year-old man, together with its histopathological and imaging findings including the dynamic MRI findings. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e139-e146)

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  • Minor salivary gland tumors in the oral cavity: Diagnostic value of dynamic contrast-enhanced MRI

    Hidenobu Matsuzaki, Yoshinobu Yanagi, Marina Hara, Naoki Katase, Jun-ichi Asaumi, Miki Hisatomi, Teruhisa Unetsubo, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka

    EUROPEAN JOURNAL OF RADIOLOGY   81 ( 10 )   2684 - 2691   2012年10月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: To evaluate the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for minor salivary gland tumors in the oral cavity.
    Materials and methods: Thirty-two patients with minor salivary gland tumors were examined preoperatively using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), Tpeak; i.e., the time that corresponded to the CImax x 0.90, and washout ratios (WR300 and WR600) were determined from contrast index (CI) curves. We compared these parameters between benign and malignant tumors and among the different histopathological types of minor salivary gland tumors. Then, we categorized the patients' CI curves into four patterns (gradual increase, rapid increase with high washout ratio, rapid increase with low washout, and flat).
    Results: Statistically significant differences in Tmax (P = 0.004) and Tpeak (P = 0.002) were observed between the benign and malignant tumors. Regarding each histopathological tumor type, significant differences in Tmax (P < 0.001), Tpeak (P < 0.001), and WR600 (P = 0.026) were observed between the pleomorphic adenomas and mucoepidermoid carcinomas. It was difficult to distinguish between benign and malignant tumors using our CI curve classification because that two-thirds of the cases were classified into the same type (gradual increase).
    Conclusion: The DCE-MRI parameters of minor salivary gland tumors contributed little to their differential diagnosis compared with those for major salivary gland tumors. During the diagnosis of minor salivary gland tumors, Tmax is useful for distinguishing between benign and malignant tumors. (c) 2011 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ejrad.2011.11.005

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  • Unusual MRI appearance of a lymphoepithelial cyst in the parotid gland

    Hidenobu Matsuzaki, Naoki Katase, Yoshinobu Yanagi, Marina Hara, Mariko Fujita, Teruhisa Unetsubo, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL RADIOLOGY   28 ( 2 )   133 - 139   2012年9月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Lymphoepithelial cysts, which are also known as branchial cleft cysts, commonly occur in the lateral cervical region. Lymphoepithelial cysts arising in the parotid gland are rare and must be distinguished from parotid gland tumors. Magnetic resonance imaging (MRI) is useful for diagnosing parotid gland lesions, and MR images of lymphoepithelial cysts typically display a cystic mass that appears homogeneously hypointense on T1-weighted images and homogeneously hyperintense on T2-weighted images. However, some parotid gland tumors that retain fluid in their inner sections show similar MRI findings to lymphoepithelial cysts. Furthermore, lymphoepithelial cysts are sometimes modified by inflammation, and these cases are hard to diagnose. We report the case of a 59-year-old female with a lymphoepithelial cyst that arose in the parotid gland. The cyst had been affected by inflammation and displayed atypical imaging findings, i.e., heterogeneous signal intensity of the liquid component and the presence of a well-enhanced capsule-like structure surrounding the liquid component. In addition, we compare the MRI findings of this case with those of two other cervical lymphoepithelial cysts.

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  • Imaging features of adenoid cystic carcinoma of the tongue with dedifferentiated components: a case report

    Yoshinobu Yanagi, Hidenobu Matsuzaki, Naoki Katase, Tomoo Onoda, Marina Hara, Teruhisa Unetsubo, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL RADIOLOGY   28 ( 2 )   157 - 165   2012年9月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Adenoid cystic carcinoma (ACC) of the head and neck region is an uncommon epithelial tumor of the major and minor salivary glands. In the oral region, although ACC arising from the minor salivary glands is the second most commonly found tumor in the tongue base, its occurrence in the anterior part of the tongue is rare. Histopathologically, ACC is categorized into three growth patterns (tubular, cribriform, and solid types) and three histologic grades (I-III) that are based on the proportions of these patterns. According to this classification, tubular- and cribriform-type ACCs are considered to be lower grade lesions, while solid-type ACCs are considered to be higher grade lesions. A fourth histopathological type has recently been reported by some authors, namely, dedifferentiation or high-grade transformation of ACC. However, very few studies have focused on the imaging features of these ACCs. We report here the case of a 63-year-old female patient with ACC of the tongue with dedifferentiated components, together with the radiological images and pathological features of this ACC.

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  • MR imaging diagnostic protocol for unilocular lesions of the jaw

    Hironobu Konouchi, Yoshinobu Yanagi, Miki Hisatomi, Hidenobu Matsuzaki, Toshihiko Takenobu, Teruhisa Unetsubo, Jun-Ichi Asaumi

    Japanese Dental Science Review   48 ( 2 )   81 - 91   2012年8月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等  

    Ameloblastomas and keratocystic odontogenic tumors (KCOT) are typical jawbone tumors. In addition, dentigerous cysts (DC) and radicular cysts are the most common cystic jawbone lesions, and simple bone cysts (SBC) are the most common jawbone pseudocysts. When these lesions are unilocular, it can be difficult to diagnose them by radiography. In recent years, adding magnetic resonance (MR) imaging to obtain information about soft tissue has been shown to improve the accuracy of jawbone lesion diagnosis. We also have reported MR imaging features of jawbone lesions. However, no systematic method for MR imaging diagnosis of jawbone lesions has been reported. In this review, we examine unilocular lesions such as ameloblastoma, KCOT, adenomatoid odontogenic tumour (AOT), DC, and SBC. First, we describe the MR imaging features of each lesion. Then, we describe our novel MR imaging diagnostic protocol. Using our MR imaging diagnostic protocol to diagnose 31 cases, we obtained a positivity rate of 71.0%. The use of our MR imaging diagnostic protocol for unilocular lesions, which are especially difficult to differentiate by radiography, would improve the morphological and qualitative diagnosis of soft tissue lesions. © 2012 Japanese Association for Dental Science.

    DOI: 10.1016/j.jdsr.2012.01.001

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  • In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Ramos Cells Using Bio-phantoms

    Takanori Sasaki, Masahiro Kuroda, Kazunori Katashima, Masakazu Ashida, Hidenobu Matsuzaki, Junichi Asaumi, Jun Murakami, Seiichiro Ohno, Hirokazu Kato, Susumu Kanazawa

    ACTA MEDICA OKAYAMA   66 ( 3 )   263 - 270   2012年6月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The roles of cell density, extracellular space, intracellular factors, and apoptosis induced by the molecularly targeted drug rituximab on the apparent diffusion coefficient (ADC) values were investigated using bio-phantoms. In these bio-phantoms, Ramos cells (a human Burkitt's lymphoma cell line) were encapsulated in gellan gum. The ADC values decreased linearly with the increase in cell density, and declined steeply when the extracellular space became less than 4 gm. The analysis of ADC values after destruction of the cellular membrane by sonication indicated that approximately 65% of the ADC values of normal cells originate from the cell structures made of membranes and that the remaining 35% originate from intracellular components. Microparticles, defined as particles smaller than the normal cells, increased in number after rituximab treatments, migrated to the extracellular space and significantly decreased the ADC values of bio-phantoms during apoptosis. An in vitro study using bio-phantoms was conducted to quantitatively clarify the roles of cellular factors and of extracellular space in determining the ADC values yielded by tumor cells and the mechanism by which apoptosis changes those values.

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  • Test-retest reliability of MRI-based disk position diagnosis of the temporomandibular joint

    Chiyomi Nagamatsu-Sakaguchi, Kenji Maekawa, Tsuyoshi Ono, Yoshinobu Yanagi, Hajime Minakuchi, Shouichi Miyawaki, Junichi Asaumi, Teruko Takano-Yamamoto, Glenn T. Clark, Takuo Kuboki

    CLINICAL ORAL INVESTIGATIONS   16 ( 1 )   101 - 108   2012年2月

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    記述言語:英語   出版者・発行元:SPRINGER HEIDELBERG  

    This study evaluated the test-retest reliability for determining the temporomandibular joint (TMJ) disk position, diagnosed using magnetic resonance imaging (MRI). These assessments were done as a base-line measurement for a prospective cohort study, which examines the risk factors for precipitation and progression of temporomandibular disorders. Fifteen subjects (mean age, 24.2 +/- 0.94 years; male/female = 8/7) were recruited from the students of Okayama University Dental School. Sagittal MR TMJ images were taken with a 1.5-T MR scanner (Magneton Vision, Siemens) in close and maximal open positions twice at about 1-week (6-11 days) interval. The images were displayed using 200% magnification on a computer screen with a commercially available image software package (OSIRIS, UIN/HCUG). Three calibrated examiners diagnosed the disk positions using the standardized criteria. The disk position of each joint was classified as normal, anterior disk displacement with or without reduction, and others. The first and second disk position diagnoses were compared, and the test-retest reliability level was calculated using the kappa index. The second disk position diagnosis was consistent with the first in 27 out of 30 joints. The calculated kappa value representing the test-retest reliability level between the first and second disk position diagnosis was 0.812. These results indicated that the test-retest reliability of MRI-based diagnosis of TMJ disk positions at about 1-week interval was substantially high, even though they were not completely consistent.

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  • Two-piece customized mold technique for high-dose-rate brachytherapy on cancers of the buccal mucosa and lip

    Hidenobu Matsuzaki, Mitsuhiro Takemoto, Marina Hara, Teruhisa Unetsubo, Yoshinobu Yanagi, Kuniaki Katsui, Norihisa Katayama, Kotaro Yoshio, Toshihiko Takenobu, Masahiro Kuroda, Susumu Kanazawa, Jun-Ichi Asaumi

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   113 ( 1 )   118 - 125   2012年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Objective. High-dose-rate (HDR) brachytherapy using a customized mold is a minimally invasive treatment for oral cancer; however, it is difficult to use this technique for buccal and lip cancers involving the commissura labiorum, owing to its anatomic form. The purpose of this study was to introduce an improved customized mold consisting of 2 pieces to allow the fixation of molds to these sites.
    Study design. Five patients with buccal carcinoma and 1 patient with lip carcinoma were treated with this technique after external beam radiotherapy. One patient with neck metastasis underwent both neck dissection and partial tumor resection before HDR brachytherapy.
    Results. At the end of the follow-up period, 5 patients had no tumor recurrence, and 1 patient had suffered local recurrence.
    Conclusions. Our technique is a viable therapeutic option for patients with buccal and lip carcinomas for whom the therapeutic modalities are limited by age, performance status, and other factors. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:118-125)

    DOI: 10.1016/j.tripleo.2011.06.038

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  • Mechanomyographic activity in the human lateral pterygoid muscle during mandibular movement

    Shigehisa Kawakami, Naoki Kodama, Naoto Maeda, Shunichi Sakamoto, Kazuhiro Oki, Yoshinobu Yanagi, Jun-Ichi Asaumi, Teruta Maeda, Shogo Minagi

    JOURNAL OF NEUROSCIENCE METHODS   203 ( 1 )   157 - 162   2012年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The activity of the lateral pterygoid muscle has been regarded to be related to the pathological condition of the temporomandibular joint (TMJ) in the craniomandibular disorders. Because the lateral pterygoid muscle is a deep muscle, a needle electrode is necessary for EMG recordings. The purpose of this study was to establish a non-invasive method for the evaluation of muscle activity of the lateral pterygoid muscle using mechanomyogram (MMG). In three male subjects, surface electromyogram (EMG) in the left masseter muscle, left anterior and posterior belly of the temporal muscle, left anterior belly of the digastric muscle and needle EMG of the inferior head of the lateral pterygoid were recorded during mandibular movement tasks simultaneously with the MMG derived from a condenser microphone in the external ear canal. There were significant positive correlations between the needle EMG signal of the lateral pterygoid muscle and the MMG signal for the tasks of static jaw opened position of 30 mm of interincisal distance (p = 0.000, R(2)=0.725), static jaw opened position of 40 mm of interincisal distance (p = 0.000, R(2) = 0.753), 5 mm protruded mandibular position (p = 0.000, R(2) = 0.653), the most protruded mandibular position (p = 0.000, R(2) = 0803). On the contrary, for the task of maximal clenching, there was no significant correlation between the EMG signal of the lateral pterygoid muscle and the MMG signal. These results suggest that the activity of the lateral pterygoid muscle could be evaluated by the MMG signals recorded in the external ear canal, unless jaw closing major muscles show active contraction. (C) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jneumeth.2011.09.026

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  • Central odontogenic fibroma of the jawbone: two case reports describing its imaging features and an analysis of its DCE-MRI findings.

    Hara M, Matsuzaki H, Katase N, Yanagi Y, Unetsubo T, Asaumi JI, Nagatsuka H

    Oral Surg Oral Med Oral Pathol Oral Radiol.   113 ( 6 )   e51-e58   2012年

  • Solid type primary intraosseous squamous cell carcinoma of the mandible: a case report with histopathological and imaging features

    Matsuzaki H, Katase N, Matsumura T, Hara M, Yanagi Y, Nagatsuka H, Iida S, Asaumi J

    Oral Surg Oral Med Oral Pathol Oral Radiol.   114 ( 5 )   e71-e77   2012年

  • 「歯科放射線学分野」の講義試験におけるe-learning(WebClassシステム)の活用

    此内浩信, 畦坪輝寿, 久富美紀, 柳 文修, 松﨑秀信, 竹信俊彦, 若狭 亨, 村上 純, 岡田俊輔, 浅海淳一

    岡山歯学会雑誌   31 ( 2 )   73 - 79   2012年

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  • Primary extranodal lymphoma of the maxilla: a case report with imaging features and dynamic data analysis of magnetic resonance imaging

    Hidenobu Matsuzaki, Naoki Katase, Marina Hara, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Miki Hisatomi, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY   112 ( 3 )   E59 - E69   2011年9月

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    記述言語:英語   出版者・発行元:MOSBY-ELSEVIER  

    Malignant lymphoma is the second-most common malignancy in the head and neck region. Waldeyer's ring is the most common site of extranodal Hodgkin's lymphoma (NHL) in that region, and a small percentage of primary extranodal NHL occurs in the oral cavity. The most common sites of extranodal NHL in the oral region are the palate and maxilla, and nearly half of extranodal NHL cases arise from bone. It is difficult to diagnose extranodal NHL because of the variety of its radiological features. We report a case of primary extranodal NHL of the maxilla in a 68-year-old female patient with atypical imaging findings, along with the results of analysis of dynamic magnetic resonance imaging (MRI). (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e59-e69)

    DOI: 10.1016/j.tripleo.2011.02.052

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  • Ameloblastic carcinoma: a case report with radiological features of computed tomography and magnetic resonance imaging and positron emission tomography

    Hidenobu Matsuzaki, Naoki Katase, Marina Hara, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Miki Hisatomi, Hironobu Konouchi, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY   112 ( 1 )   E40 - E47   2011年7月

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    記述言語:英語   出版者・発行元:MOSBY-ELSEVIER  

    Ameloblastic carcinoma is a rare malignant odontogenic carcinoma that has metastatic potential, and because of its rare incidence, there are few reports focusing on its radiologic imaging. If it shows aggressive appearances, it can be diagnosed as malignant tumor. But in case of negative appearance, it is difficult to distinguish ameloblastic carcinoma from ameloblastoma. We report a case of ameloblastic carcinoma of the maxilla in a 76-year-old female patient with radiologic images and pathologic features. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e40-e47)

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  • Comparison between late-course accelerated hyperfractionation radiotherapy and concurrent chemoradiotherapy in patients with esophageal carcinoma

    Qiang Lin, Xan-Shu Gao, Xue-Yng Qiao, Chao-Xng Liu, Zhi-Guo Zhou, Zhi-Jun Guo, Yan-Nan Zhao, Kun Chen, Juni-Chi Asaumi

    ONCOLOGY LETTERS   2 ( 3 )   557 - 564   2011年5月

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    記述言語:英語   出版者・発行元:SPANDIDOS PUBL LTD  

    This study aimed to compare the efficacy of late-course accelerated hyperfractionation radiotherapy (LAFR) and concurrent chemoradiotherapy (CRT) in patients with esophageal carcinoma and to evaluate the side effects of the two treatments. A total of 22 patients with primary esophageal squamous cell carcinoma were prospectively treated with LAFR, while 25 patients, during the same period, served as the control group and received CRT. The 22 patients in the LAFR group received conventional fractionated radiotherapy of 30 Gy over a 3-week period (5 daily fractions of 2.0 Gy per week), followed by accelerated hyperfractionated radiotherapy of 30 Gy for 2 weeks (twice daily, 1.5 Gy per fraction, with a minimal interval of 6 h between fractions, 10 fractions per week). The 25 patients in the CRT group received conventional fractionated radiotherapy of 50 Gy for 5 weeks, with 5 daily fractions of 2.0 Gy per week. Chemotherapy was started on the first day of irradiation (cisplatin 52.5 mg/m(2) on Day 1 and 5-fluorouracil 700 mg/m(2) on Days 1-5, repeated four times every 28 days). The median survival time in the LAFR and CRT groups were noted to be 17 and 21 months, respectively. The 1- and 2-year overall survival rates were 63.6 and 31.6% in the LAFR group and 76 and 57.4% in the CRT group (chi(2)=1.670; P=0.196). The median local control in the LAFR group was 17 months, while that in the CRT group was not determined. The 1- and 2-year local control rates were 54.5 and 39% in the LAFR group while those in the CRT group were 82.2 and 66.1% (chi(2)=3.527; P=0.060). The overall survival and local control rates of the LAFR group were lower than those of the CRT group, although the difference was not significant. The metastasis rates of the two groups were also not significantly different (chi(2)=0.030; P=0.862). Both acute and late adverse events in the two groups were tolerated. The side effects, including hematological toxicities, severe nausea and vomiting, and severe anorexia were significantly less in the LAFR group than those in the CRT group (P<0.05). In this small-sample exploratory study, the overall survival and local control rates were lower with LAFR than with CRT, but the difference was not significant. Moreover, LAFR was found to have fewer side effects and be more cost-effective compared to CRT. The long-term effects on LAFR survival should be evaluated in a phase III clinical trial.

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  • Diagnostic value of dynamic contrast-enhanced MRI for unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2-weighted or STIR MR images

    Miki Hisatomi, Yoshinobu Yanagi, Hironobu Konouchi, Hidenobu Matsuzaki, Toshihiko Takenobu, Teruhisa Unetsubo, Jun-ichi Asaumi

    ORAL ONCOLOGY   47 ( 2 )   147 - 152   2011年2月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    Typical MR images of ameloblastomas on T2-weighted image (WI) or short inversion time inversion-recovery (STIR) show multiple bright high-signal-intensity loci on a high-signal-intensity background. Unilocular cystic-type ameloblastomas show homogeneously bright high signal intensity on T2WI or STIR as a water-like signal intensity. Therefore, it is difficult to distinguish unilocular cystic-type ameloblastoma from other cystic lesions such as keratocystic odontogenic tumors, radicular cysts (residual cysts) and dentigerous cysts only on the basis of MRI signal intensity. In the present study, we evaluated whether contrast-enhanced (CE)-T1WI and dynamic CE-MRI (DCE-MRI) could provide additional information for differential diagnosis in unilocular cystic-type ameloblastoma. Images from 12 cases of suspected unilocular cystic-type ameloblastoma were evaluated in the present study. Of them, 5 had areas suspected of indicating a solid component on T1WI and T2WI (or STIR). Ten had undergone additional CE-T1WI and DCE-MRI. On 5 of 10 cases of CE-T1WI, a tiny enhancement area was detected. On 6 of 10 DCE-images, a time-course enhanced area which was suspected to be a solid component was detected. CE-T1WI was helpful in the diagnosis of ameloblastoma because the tiny enhanced areas were taken to indicate possible solid components. Moreover, the rim-enhancement area on CE-T1WI could be divided into small regions of interest, and some of these showed slightly increased enhancement on DCE-MRI, which was taken to indicate a solid component and/or intramural nodule with focal invasion of ameloblastoma tissue. DCE-MRIs of the four remaining cases, which provided no clues to the diagnosis of ameloblastoma in the manner of the above descriptions, showed thicker rim enhancement than odontogenic cysts. Thus, CE-T1WI and DCE-MRI were helpful in the differential diagnosis of unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2WI or STIR. (C) 2010 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.oraloncology.2010.11.009

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  • Preliminary study evaluating the accuracy of MRI images on CBCT images in the field of orthodontics

    Kiyoshi Tai, Jae Hyun Park, Kunio Hayashi, Yoshinobu Yanagi, Jun-Ichi Asaumi, Seiji Iida, Je-Won Shin

    Journal of Clinical Pediatric Dentistry   36 ( 2 )   211 - 218   2011年1月

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    記述言語:英語   出版者・発行元:Journal of Clinical Pediatric Dentistry  

    Objective: The purpose of this study was to explore the 3-dimensional (3D) accuracy of magnetic resonance imaging (MRI) on cone-beam computed tomography (CBCT) images after the registration of MRI images on CBCT images. Materials and Methods: Three Japanese adult females volunteered for this study. To transform digital imaging and communication in medicine (DICOM) data derived from MRI and CBCT images into polygon data, five software programs were used. CBCT and MRI images were obtained within one week, and both were registered by the iterative closest point (ICP) method. To assess the accuracy of the composite MRI-CBCT, the measurement errors of the MRI-CBCT were verified. Measurement values were compared using frontal and cephalometric soft-tissue landmarks. Differences were analyzed using the non-parametric Mann-Whitney U test. Results: There were no significant linear measurement errors (P 0.05) when the images were measured from the superimposed MRI-CBCT images. Conclusion: The MRI images attained from MRI-CBCT registration showed accurate 3D linear measurements.

    DOI: 10.17796/jcpd.36.2.r7853hp574045414

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  • Manifestation of preferred chewing side for hard food on TMJ disc displacement side

    A. Ratnasari, K. Hasegawa, K. Oki, S. Kawakami, Y. Yanagi, J-I Asaumi, S. Minagi

    JOURNAL OF ORAL REHABILITATION   38 ( 1 )   12 - 17   2011年1月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

    The purpose of this study was to reveal the relationship between chewing-side preference and anterior disc displacement (ADD) of the TMJ. Thirty-two healthy subjects with ages ranging from 26 to 34 years were selected from volunteer students at the Okayama University Dental School. Subjects were asked to chew freely with two kinds of test foods, beef jerky (hard food) and chiffon cake (soft food), thus expecting different amounts of mechanical loading on the TMJ. One, 4, and 7 s after starting the mastication, subjects were asked to open their mouth momentarily to have a digital image of their mouth taken. The bolus placement area was measured by processing the digital images, calculated as the number of pixel of bolus area. Area asymmetry index was used for the determination of preferred chewing side (PCS). Oblique sagittal MRI scanning in the closed mouth position was taken to evaluate the articular disc position. In asymptomatic subjects with ADD, a significant predominance of the PCS on the ipsilateral side of ADD was observed during the mastication of hard food. On the contrary, no correlation was found between unilateral ADD and PCS for the soft food. From the results of this study, it is suggested that ADD is the associating factor of PCS for hard food. Therefore, it would be necessary to break down the concept of PCS into at least two categories, one for hard food and one for soft food, considering the mechanical loading on the TMJ.

    DOI: 10.1111/j.1365-2842.2010.02128.x

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  • A PRECLINICAL IN VIVO INVESTIGATION OF HIGH-INTENSITY FOCUSED ULTRASOUND COMBINED WITH RADIOTHERAPY

    Chao-Xing Liu, Xian-Shu Gao, Liu-Lin Xiong, Hui-Yu Ge, Xin-Yong He, Ting Li, Hong-Juan Zhang, Hong-Zhong Bai, Qiang Lin, Ming Zhang, Jing Zhao, Wei Xiong, Yu Bai, Junichi Asaumi

    ULTRASOUND IN MEDICINE AND BIOLOGY   37 ( 1 )   69 - 77   2011年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region. (E-mail: xsgao777@hotmail.com) (C) 2011 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.

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  • 角化嚢胞性歯原性腫瘍の診断におけるMRIのT1強調像の有用性

    此内浩信, 久富美紀, 柳 文修, 松﨑秀信, 竹信俊彦, 若狭 亨, 村上 純, 畦坪輝寿, 浅海淳一

    岡山歯学会雑誌   30 ( 2 )   69 - 74   2011年

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  • インプラントを希望して岡山大学歯学部を受診した患者の初診時パノラマエックス線像の検討.

    久富美紀, 竹信俊彦, 若狭亨, 此内浩信, 柳文修, 松﨑秀信, 村上純, 畦坪輝寿, 浅海淳一

    岡山歯学会雑誌   30 ( 1 )   11 - 16   2011年

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  • The utility of three-dimensional dynamic contrast-enhanced magnetic resonance imaging in delineating vessel-rich regions: a case report of an aneurysmal bone cyst of the mandible

    Yoshinobu Yanagi, Mariko Fujita, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Naoki Katase, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL RADIOLOGY   26 ( 2 )   110 - 115   2010年12月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Aneurysmal bone cysts (ABCs) are classified as bone-related lesions based on the 2005 World Health Organization histological classification of odontogenic tumors. Most ABCs are diagnosed using a combination of conventional radiography, computed tomography, magnetic resonance imaging (MRI), and digital subtraction angiography. ABCs should be differentiated from true cysts or other pseudocysts because their treatment is different. Additionally, unlike other cysts, ABCs pose a hemorrhagic risk in surgery; thus, preoperative evaluation of intralesional blood flow is required. Here we report a case of a mandibular ABC in a 39-year-old woman and focus on its dynamic contrast-enhanced MRI (DCE-MRI) features. On DCE-MRI, the lesion was divided into two areas according to the enhancement pattern: the blood-pooling and blood-flow areas. The series of DCE-MR images of the blood-pooling area showed marked enhancement of the margin, but no enhancement in the inner part of the cavity. Additionally, the time-signal intensity curve (TIC) demonstrated no change in the signal intensity (SI) until approximately 15 min after gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) administration. In contrast, the series of DCE-MR images of the blood-flow area exhibited marked enhancement in the cyst cavity in the early phase. The TIC showed a rapid increase in SI in the early phase, followed by a rapid decrease until 150 s, and finally a gradual decrease until approximately 15 min after Gd-DTPA administration. Thus, in the current patient, preoperative DCE-MRI clearly delineated the vessel-rich area within the lesion.

    DOI: 10.1007/s11282-010-0048-3

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  • Human dental age estimation using third molar developmental stages: Accuracy of age predictions not using country specific information

    P. W. Thevissen, A. Alqerban, J. Asaumi, F. Kahveci, J. Kaur, Y. K. Kim, P. Pittayapat, M. Van Vlierberghe, Y. Zhang, S. Fieuws, G. Willems

    FORENSIC SCIENCE INTERNATIONAL   201 ( 1-3 )   106 - 111   2010年9月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    Unquestionable forensic age investigations are based on statistical models constructed on a sample containing subjects of identical origin as the examined individual. In cases where corresponding models are unavailable, the established report has to describe the possible effects of this unrelated information on the predicted age outcome. The aim of this study is to collect country specific databases of third molar development and to verify how the related dental age estimations are influenced if we were to use dental developmental information only from Belgium or from all collected countries together.
    Data containing third molar developmental stages scored following Gleiser and Hunt (modified by Kohler) were collected from 9 country specific populations (Belgium, China, Japan, Korea, Poland, Thailand, Turkey, Saudi-Arabia and South-India). Age predictions were obtained from a training dataset and validated on a test dataset. Bayes rule using the repeated third molar scores is applied to get age predictions and prediction intervals. Three age predictions were compared for males and females separately. For the first prediction, the training dataset contains only Belgian subjects. For the second prediction, the training dataset for each country consists only of subjects of the country itself. For the final prediction, subjects from all countries are pooled into one common training dataset. Besides the (absolute) difference between the chronological age and the predicted age, specific interest lies in the juvenile-adult distinction.
    In the age range from 16 to 22 years 6982 subjects (3189 male and 3793 female) were analyzed.
    Using information on third molar development from Belgium compared to information from the country specific databases hardly increased the mean absolute differences (MAD) and mean squared errors (MSE): the MAD and MSE increased on average with 0.5 and 2.5 months with maximal increases of, respectively 1.6 and 7.3 months.
    Using information from all countries pooled compared to country specific information provided even on average negligible increases (0.05 and 0.2 months for MAD and MSE, respectively). For the juvenile-adult discrimination, using information from all countries instead of country specific information yielded comparable performances. Using Belgium instead of country specific information increased the percentage of correctly identified juveniles, but decreased the percentage of correctly identified adults.
    The adult-juvenile discrimination based on information used from Belgium provides judicially the best applied reference. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.forsciint.2010.04.040

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  • Usefulness of MRI and dynamic contrast-enhanced MRI for differential diagnosis of simple bone cysts from true cysts in the jaw

    Yoshinobu Yanagi, Jun-ichi Asaumi, Teruhisa Unetsubo, Masakazu Ashida, Toshihiko Takenobu, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Naoki Katase, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY   110 ( 3 )   364 - 369   2010年9月

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    記述言語:英語   出版者・発行元:MOSBY-ELSEVIER  

    Introduction. It can be difficult to differentiate simple bone cysts (SBCs) from true cysts in the jaw when these lesions appear unilocular. The present study reports the MR imaging of subjects with SBCs and describes the diagnostic value of the MRI findings.
    Materials and methods. Ten subjects with SBCs in the jaw were examined using MRI. T1- and T2-weighted images (T1WI, T2WI) were obtained, and contrast-enhanced images and dynamic contrast-enhanced MRI (DCE-MRI) were acquired.
    Results. In all cases, the contrast-enhanced T1WI acquired approximately 6 minutes after the administration of GdDTPA showed marked enhancement of the margin and slight enhancement of the inner part of the cyst cavity. In all cases, the time-signal intensity (SI) curves show a gradual increase in the SI until approximately 15 minutes after the administration of Gd-DTPA. These findings might not be observed on the DCE-MRIs of the other true cysts with epithelial lining that show no enhancement in a cavity.
    Conclusion. MRI, especially DCE-MRI, can provide useful information for distinguishing SBCs from other cysts. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:364-369)

    DOI: 10.1016/j.tripleo.2010.05.001

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  • A case of malignant fibrous histiocytoma of the maxillary sinus

    Yoshinobu Yanagi, Jun Murakami, Miki Hisatomi, Naoki Katase, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY   109 ( 3 )   E99 - E104   2010年3月

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    記述言語:英語   出版者・発行元:MOSBY-ELSEVIER  

    Malignant fibrous histiocytoma (MFH) is recognized as one of the most common soft tissue sarcomas arising in late adulthood. Most MFHs arise from the extremities and the retroperitoneum, thus the incidence of head and neck MFH is relatively low. Because of its rare incidence, there are very few reports focusing on the imaging features of MFH arising in the maxillary sinus. A case of MFH of the maxillary sinus in a 67-year-old male patient is reported including imaging and pathological features. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e99-e104)

    DOI: 10.1016/j.tripleo.2009.11.032

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  • A new phantom using polyethylene glycol as an apparent diffusion coefficient standard for MR imaging

    Ryohei Matsuya, Masahiro Kuroda, Yoshitsugu Matsumoto, Hirokazu Kato, Hidenobu Matsuzaki, Junichi Asaumi, Jun Murakami, Kazunori Katashima, Masakazu Ashida, Takanori Sasaki, Tetsuro Sei, Kengo Himei, Kuniaki Katsui, Norihisa Katayama, Mitsuhiro Takemoto, Susumu Kanazawa, Seiichi Mimura, Seiichiro Oono, Takuichi Kitayama, Seiji Tahara, Keiji Inamura

    INTERNATIONAL JOURNAL OF ONCOLOGY   35 ( 4 )   893 - 900   2009年10月

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    記述言語:英語   出版者・発行元:SPANDIDOS PUBL LTD  

    In recent years, magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) has seen wide clinical use, such as for early detection of cerebrovascular diseases and whole body screening for tumors. The apparent diffusion coefficient (ADC) standard phantom, which mimics the ADC values of several lesions in the body, is indispensable for the development of new pulse sequences for DWI, such as diffusion-weighted whole-body imaging with background body-signal suppression (DWIBS). However, information on the ADC values of the previously reported ADC standard phantoms is limited, because these phantoms were made using only a few different materials at a limited range of concentrations, and the ADC values were measured only at certain temperatures. It has been considered difficult, if not impossible, to create a phantom that provides arbitrary ADC values, because it is difficult to calculate the concentrations of the materials and the temperature at ADC measurement. In this study, we used polyethylene glycol (PEG) as a phantom material, and developed an empirical formula to calculate the PEG concentration at any measurement temperature to obtain arbitrary ADC values of the phantom. DWI images of phantoms made using seven different PEG concentrations were taken under heating from 17 to 46 degrees C at 1 degrees C intervals. Using ADC values calculated from these DWI images, we developed two empirical formulas: i) an empirical formula to calculate the ADC values of phantoms made using any PEG concentration at any measurement temperature; and ii) an empirical formula to calculate PEG concentrations to obtain arbitrary ADC values at any measurement temperature. We inspected the accuracy of these empirical formulas by newly made PEG phantoms. A comparison between the ADC values calculated with the empirical formulas and the measured ADC values confirmed the high accuracy of these formulas. PEG phantoms are safe, inexpensive and easy to make, compared with the previously reported ADC standard phantoms. Our empirical formulas enable us to calculate PEG concentrations that provide arbitrary ADC values at any measurement temperature. The empirical formulas could be used within a range of ADC values from 0.37x10(-3) to 3.67x10(-3) mm(2)/s, PEG concentrations from 0 to 120 mM, and measurement temperatures from IS to 45 degrees C. Using these formulas, it would be possible to make standard phantoms that mimic the ADC values of any clinical lesions. The PEG phantom might thus be an excellent new ADC standard phantom for MRI with DWI.

    DOI: 10.3892/ijo_00000404

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  • In vitro experimental study of the relationship between the apparent diffusion coefficient and changes in cellularity and cell morphology

    Yoshitsugu Matsumoto, Masahiro Kuroda, Ryohei Matsuya, Hirokazu Kato, Koichi Shibuya, Masataka Oita, Atsushi Kawabe, Hidenobu Matsuzaki, Junichi Asaumi, Jun Murakami, Kazunori Katashima, Masakazu Ashida, Takanor Sasaki, Tetsuro Sei, Susumu Kanazawa, Seiichi Mimura, Seiichiro Oono, Takuichi Kitayama, Seiji Tahara, Keiji Inamura

    ONCOLOGY REPORTS   22 ( 3 )   641 - 648   2009年9月

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    記述言語:英語   出版者・発行元:SPANDIDOS PUBL LTD  

    Diffusion-weighted magnetic resonance imaging (MRI) is frequently used clinically, and is available for the whole-body screening for tumors. The exact mechanism by which the apparent diffusion coefficient (ADC) value decreases in tumorous tissue remains unclear, although various theories have been proposed, including intracellular and extracellular factor theories. It is impossible to distinguish each factor in the intracellular and extracellular spaces as the source of MR signal generation by means of conventional comparison between MR images and pathological specimens. Other factors which have been reported to affect ADC include cellularity and cellular edema of human tissues, and temperature of phantoms at the time of measurement. We employed a new technique that enables cellular MR imaging using a newly developed bio-phantom containing a living culture tumor cell line, Jurkat-N1. We investigated possible reasons for observed decreases in ADC values for tumors, and we considered the contribution of both the intracellular and extracellular space to such a decrease. The ADC values of the bio-phantom increased with increasing heat exposure from 27 to 45 degrees C. ADC values also increased after the destruction by sonication of tumor cell membranes. ADC values decreased as cellularity increased in the bio-phantorn. ADC values decreased due to cellular edema caused by a low salt concentration in the bio-phantom. Changes in pressure in the bio-phantom had no effect on the observed ADC values. We calculated both the intracellular ADC and extracellular ADC values using the ADC values, cellularity, and cellular volume of Jurkat-N1 cells in the bio-phantom. The extracellular ADC values in the bio-phantom were estimated to be lower than the ADC value of distilled water. These results indicate that not only intracellular ADC values, but also extracellular ADC values contribute to the determination of the ADC values of bio-phantoms. This is the first report to have examined the contribution of intracellular and extracellular space on the ADC values of bio-phantoms containing cultured tumor cells.

    DOI: 10.3892/or_00000484

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  • Dynamic contrast-enhanced magnetic resonance imaging for estimating tumor proliferation and microvessel density of oral squamous cell carcinomas

    Teruhisa Unetsubo, Hironobu Konouchi, Yoshinobu Yanagi, Jun Murakami, Masae Fujii, Hidenobu Matsuzaki, Miki Hisatomi, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL ONCOLOGY   45 ( 7 )   621 - 626   2009年7月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    We evaluated the relationship between histopathological prognostic factors, tumor proliferation microvessel density (MVD), and enhancement parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in oral squamous cell carcinoma (SCC). Twenty-eight T2 and T3 patients with primary oral SCC underwent DCE-MRI using three-dimensional fast imaging with a steady-state precession sequence. Tumor cell proliferation and MVD of all surgical specimens were evaluated using immunohistochemical staining with CD34 and the antibody for proliferating cell nuclear antigen (PCNA). Regression analysis was used to statistically analyze the relationship between the PCNA labeling index or MVD and each of three DCE-MRI parameters: maximum CI (CI-max), maximum CI gain (CI-gain) and the CI-gain / CI-max ratio. The PCNA labeling index and MVD showed significant correlations with the CI-gain/CI-max ratio (P = 0.0012, r = 0.581 and P = 0.00141, r = 0.574, respectively). The assessment of DCE-MRI parameters may prove to be a valuable non-invasive method for assessing tumor cell proliferation and MVD of patients with oral cancer. (C) 2008 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.oraloncology.2008.09.003

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  • A case of unerupted lower primary second molar associated with compound odontoma.

    Teruhisa U, Murakami J, Hisatomi M, Yanagi Y, Asaumi J

    The Open Dentistry Journal   3 ( 1 )   173 - 176   2009年

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  • Analysis of magnetic resonance images of disk positions and deformities in 1,265 patients with temporomandibular disorder.

    Choi YS, Asaumi J, Hisatomi M, Unetsubo T, Yanagi Y, Matsuzaki H, Konouchi H, Hwang EH, Lee SR

    The Open Dentistry Journal   3 ( 1 )   1 - 20   2009年

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  • 小児患者における下顎側切歯部に認められた過剰歯の1例

    片嶋和典, 村上 純, 久富美紀, 柳 文修, 松﨑秀信, 此内浩信, 畦坪輝寿, 若狭 亨, 繁原 宏, 浅海淳一

    岡山歯学会雑誌.   28 ( 1 )   61 - 64   2009年

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  • 岡山大学病院周術期管理センター(歯科部門)設立後5ヶ月間の活動内容および今後の展開

    山中玲子, 曽我賢彦, 縄稚久美子, 柳文修, 児玉直紀, 中田貴, 三浦留美, 羽川操, 山根美榮子, 森田学, 高柴正悟, 浅海淳一, 皆木 省吾, 吉山昌宏, 下野勉, 窪木拓男, 佐々木朗, 森田潔

    岡山歯学会雑誌   28 ( 1 )   37 - 41   2009年

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  • 3D optimal design of open type magnetic circuit producing uniform field

    N. Takahashi, S. Nakazaki, H. Kato, J. Asaumi

    COMPEL-THE INTERNATIONAL JOURNAL FOR COMPUTATION AND MATHEMATICS IN ELECTRICAL AND ELECTRONIC ENGINEERING   28 ( 5 )   1236 - 1248   2009年

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    記述言語:英語   出版者・発行元:EMERALD GROUP PUBLISHING LIMITED  

    Purpose - The purpose of this paper is to provide an approach to the optimal design of open type magnetic circuit of permanent magnet having uniform field.
    Design/methodology/approach - The Biot-Savart's law and evolution strategy are used for the design of permanent magnet configuration. The optimization is carried out by changing the objective function, dimension of target region, and target flux density.
    Findings - The obtained uniformity is affected by the selection of objective function, dimension of target region, and target flux density. About 50 ppm uniformity of 0.08 T in the imaging area is obtained by changing the dimensions, dimension of target region, and target flux of 3D magnets and the amplitudes of magnetization and the directions of magnetization vectors.
    Originality/value - This paper describes a new approach for obtaining the optimal shape of open type magnetic circuit which may be used when magnetic resonance imaging is carried out.

    DOI: 10.1108/03321640910969485

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  • Evaluation of panoramic radiographs taken at the initial visit at a department of paediatric dentistry

    J-I Asaumi, M. Hisatomi, Y. Yanagi, T. Unetsubo, Y. Maki, H. Matsuzaki, Y. Honda, H. Konouchi

    DENTOMAXILLOFACIAL RADIOLOGY   37 ( 6 )   340 - 343   2008年9月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    Objectives: To examine Oral and maxillofacial lesions other than those related to the chief complaint in panoramic radiographs taken at the department of paediatric dentistry at our hospital.
    Methods: We retrospectively reviewed all 1092 patients who had visited the department of paediatric dentistry at our hospital and had a panoramic radiograph taken between August 1999 and October 2004. The following information was obtained from the patients' files and panoramic radiographs: gender, age, chief complaints and the presence or absence of lesions.
    Results: Lesions were observed in 140 of the 1092 panoramic radiographs (12.8%). Among the 140 patients discovered to have lesions in the panoramic radiographs, 66 (47.1%, or 6.05% of the entire group Of 1092 patients) had different lesions from those underlying the chief complaint. These 66 patients ages ranged from 3 years to 14 years and the lesions involved 39 (59.1%) missing teeth, 20 (30.3%) mesiodentes, 4 supernumerary teeth, I odontoma, I radicular cyst and 1 impacted tooth. The missing teeth were observed in the central and lateral incisor, canine, and first and second premolar positions of both jaws, especially in the lower lateral incisor and upper central incisor positions.
    Conclusions: We were able to detect incidental lesions at a rate of 6.05% (66 of 1092 patients) and at a relatively early age (mean 6.8 years) in the present study. Early treatment of these lesions could avoid maxillofacial deformity and other complications.

    DOI: 10.1259/dmfr/31214423

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  • A design of permanent magnet array for unilateral NMR device

    Hirokazu Kato, Kanji Kishi, Norio Takahashi, Jun-Ichi Asaumi, Yasutoshi Honda, Yoshinobu Yanagi, Masaaki Aoki

    CONCEPTS IN MAGNETIC RESONANCE PART B-MAGNETIC RESONANCE ENGINEERING   33B ( 3 )   201 - U2   2008年8月

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    記述言語:英語   出版者・発行元:JOHN WILEY & SONS INC  

    We have designed a three-dimensional magnetic circuit consisting of various pieces of magnetic blocks for a unilateral MRI device, which generates a homogeneous magnetic flux density at a remote region. The direction of the remanent flux density of the main outer magnetic blocks is parallel to the surface of the device; hence the direction of the magnetic flux density in the remote region is also parallel to the surface of the device. The magnitudes of the remanent flux density of the magnetic blocks are adjusted so as to minimize the variation of the magnetic flux density in the remote region. This magnetic circuit, with an outer dimension of 400 mm X 400 mm X 200 mm, produces a magnetic flux density in a 20 mm X 20 mm X 5 mm region of interest at a distance of 55 mm from the surface of the device with a magnitude of 64.5 mT (2.75 MHz in resonant frequency) and a uniformity of 275 ppm (755 Hz in band width). (C) 2008 Wiley Periodicals, Inc.

    DOI: 10.1002/cmr.b.20115

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  • Phase I trial of escalating-dose cisplatin with 5-fluorouracil and concurrent radiotherapy in Chinese patients with esophageal cancer

    Qiang Lin, Xian-Shu Gao, Xue-Ying Qiao, Zhi-Guo Zhou, Ping Zhang, Kun Chen, Yan-Nan Zhao, Junichi Asaumi

    ACTA MEDICA OKAYAMA   62 ( 1 )   37 - 44   2008年2月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We defined the maximum-tolerated dose (MTD) of chemoradiotherapy (cisplatin (CDDP) with 5-fluorouracil (5-FU) and concurrent chemoradiotherapy) for Chinese patients with esophageal cancer. Twenty-one previously untreated patients with primary esophageal cancer were entered into this study. Escalating doses of CDDP with 5-FU were administered in a modified Fibonacci sequence, with concurrent conventional fractionation radiotherapy (CFR) of 60 Gy or 50 Gy. The starting doses were CDDP 37.5 mg/m(2) on day 1, and 5-FU 500 mg/m(2) on days 1-5, respectively. The regimen was repeated 4 times every 28 days. If no dose-limiting toxicity (DLT) was observed, the next dose level was applied. The procedures were repeated until DLT appeared. The MTD was declared to be 1 dose level below the level at which DLT appeared. DLT was grade 3 radiation-induced esophagitis at a dose level of CDDP 60 mg/m(2) with 5-FU 700 mg/m(2) and concurrent 60 Gy CFR. MTD was defined as CDDP 52.5 mg/m(2) with 5-FU 700 mg/m(2) and concurrent 50 Gy CFR. The MTD of CDDP with 5-FU and in concurrent chemoradiotherapy for Chinese patients with esophageal cancer is CDDP 52.5 mg/m(2) on day 1 and 5FU 700 mg/m(2) on days 1-5, repeated 4 times every 28 days, and concurrent 50 Gy CFR. Further evaluation of this regimen in a prospective phase II trial is ongoing.

    DOI: 10.18926/AMO/30984

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  • A spindle cell carcinoma presenting with osseous metaplasia in the gingiva: A case report with immunohistochemical analysis

    Naoki Katase, Ryo Tamamura, Mehmet Gunduz, Jun Murakami, Jun-Ichi Asaumi, Goichi Tsukamoto, Akira Sasaki, Hitoshi Nagatsuka

    Head and Face Medicine   4 ( 1 )   28   2008年

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    記述言語:英語  

    Background. Spindle cell carcinoma (SpCC) is a rare, high malignant variant of squamous cell carcinoma (SCC), which shows biphasic proliferation of conventional SCC component and malignant spindle shape cells with sarcomatous appearance. Methods. A case of Spindle cell carcinoma with bone-like calcified materials, occurring at the mandibular molar region of 71-years-old Japanese male patient was presented with gross finding, histological findings and MRI image. To identify the characteristics of the bone-like materials, immunohistochemistry were performed. Results. Histologically, the cancer cells were composed of spindle cells and epithelial cells which form nests with prominent keratinization. Histological findings showed typical histology of the SpCC, however, as an uncommon finding, spatters of calcified, bone-like materials were observed in between the cancer cells. Immunohistochemistry revealed that cancer cells were positive for cytokeratins and vimentin to a varying degree and negative for Desmin, S-100, Osteopontin, BMP-2 or BMP-4. These findings implied that the calcified materials were formed by metaplasia of the stromal cells. Discussion. Bone-like materials formation by osseous and/or cartilaginous metaplasia of the stroma in the carcinoma has been reported. However, the detailed mechanism of these metaplasia and affection on the clinical feature, prognosis and therapies are not well established. In summary, we presented an unique case of SpCC, which has not been described in the literature. © 2008 Katase et al
    licensee BioMed Central Ltd.

    DOI: 10.1186/1746-160X-4-28

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  • 岡山大学歯学部の口腔領域悪性腫瘍患者におけるFDG-PET検査の有用性に関する検討

    久富美紀, 此内浩信, 柳文修, 松﨑秀信, 畦坪輝寿, 加地充昌, 金沢右, 浅海淳一

    岡山歯学会雑誌   27 ( 2 )   99 - 104   2008年

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  • Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors

    Miki Hisatomi, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Yuu Maki, Jun Murakami, Hidenobu Matsuzaki, Yasutoshi Honda, Hironobu Konouchi

    ORAL ONCOLOGY   43 ( 9 )   940 - 947   2007年10月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study. The parameters included CImax300 or CImax6003 which was the contrast index (CI) at maximal contrast enhancement upon 300 s or 600 s, and T-max, which was the time that corresponded to the CImax300. Washout ratio (WR300 or WR600) was defined as follows: CImax300 - CI300s/CImax300 or CImax600 - CI600s/CImax600 X 100 (%), where CI300 or CI600 was the CI at 300 s or 600 s after contrast medium administration. We obtained the following results from the analysis of DCE-MRI parameters; (a) The salivary gland tumors were categorized into three Cl curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax > 210 s and WR300 < 10%, Warthin tumor; Tmax < 60 s and WR300 > 40%, and malignant tumor; 60 s < Tmax < 210 s and 10% < WR300 < 30%; (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions. Of the 20 pleomorphic adenomas, 18 (90.0%) were successfully differentiated from malignant tumors. All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors. Of 12 the malignant tumors, 11 (91.7%) were successfully differentiated from pleomorphic adenomas. All malignant tumors were successfully differentiated from Warthin tumors. Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR. (c) 2006 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.oratoncotogy.2006.11.009

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  • Rare associations of dens invaginatus and mesiodens

    Eduardo Kazuo Sannomiya, Jun-Ichi Asaumi, Kanji Kishi, Gisele da Silva Dalben, Sao Paulo

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY   104 ( 2 )   E41 - E44   2007年8月

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    記述言語:英語   出版者・発行元:MOSBY-ELSEVIER  

    Dens invaginatus is a developmental variation resulting from an alteration in the normal growth pattern of the dental papilla. Synonyms of this disturbance include dens in dente, invaginated odontome, tooth inclusion, and dentoid in dente. Radiographically, it is observed as infolding of a radiopaque ribbon-like structure, with equal density as enamel, extending from the cingulum into the root canal and sometimes reaching the root apex, assigning the appearance of a small tooth within the coronal pulp cavity. This article presents 2 case reports. The first describes an 8-year-old girl with dens invaginatus in a mesiodens; the second report describes a 16-year-old boy presenting with 2 mesiodens, both associated with dens invaginatus.

    DOI: 10.1016/j.tripleo.2007.01.005

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  • Depletion of O-6-methylguanine-DNA methyltransferase by O-6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines

    Jun Murakami, You-Jin Lee, Susumu Kokeguchi, Hidetsugu Tsujigiwa, Jun-Ichi Asaumi, Hitoshi Nagatsuka, Kazuhiro Fukui, Masahiro Kuroda, Noriaki Tanaka, Nagahide Matsubara

    ONCOLOGY REPORTS   17 ( 6 )   1461 - 1467   2007年6月

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    記述言語:英語   出版者・発行元:PROFESSOR D A SPANDIDOS  

    O-6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme whose expression is controlled by its promoter methylation. A cell that expresses a low amount of MGMT is known to be more sensitive to the antiproliferative effects of alkylating agents. We have previously shown that the colorectal cancer patients treated with 5-fluorouracil (5-FU) as adjuvant chemotherapy had a better prognosis when the tumor revealed hypermethylation in its MGMT promoter. Therefore, we sought to investigate the relationship between the expression levels of MGMT and the antitumor effect of 5-FU in vitro by using two colon adenocarcinoma and four oral cancer cell lines with a variety of MGMT expression. We also investigated the effects of MGMT depletion by O-6-benzylguanine (O-6-BG), a potent inhibitor of MGMT. The 5-FU treatment uniformly depleted protein and mRNA expression of MGMT in all cell lines examined. Cell lines expressing low levels of MGMT were sensitive to 5-FU. On the other hand, cells expressing high levels of MGMT were less sensitive to 5-FU. The 5-FU treatment exhibited a better antiproliferative effect on the cells expressing high levels of MGMT by the pretreatment of O-6-BG. Depletion of MGMT by O-6-BG enhanced the antitumor effect of 5-FU. Assessment of the levels of MGMT expression in cancer cells and the control of its expression could contribute to the effective chemotherapy by 5-FU especially in patients who previously were considered as low-responsive individuals whose tumors have high levels of MGMT.

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  • Diagnosis of multiple synchronously occurring cystic jaw lesions in 23 patients: Prognostic implications related to basal cell nevus syndrome

    Jun-Ichi Asaumi, Jun Murakami, Yoshinobu Yanagi, Miki Hisatomi, Hidenobu Matsuzaki, Yuu Maki, Teruhisa Unetsubo, Yasutoshi Honda, Hironobu Konouchi

    Oral Radiology   23 ( 1 )   16 - 18   2007年6月

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    記述言語:英語  

    Objectives. We rarely find multiple cystic lesions in the jaw in panoramic radiographs. Most reports of multiple cystic lesions have described keratocystic odontogenic tumors (KOTs) in patients with basal cell nevus syndrome. In this study, we performed radiographic and clinical examinations of patients with multiple cystic jaw lesions found during their first visit to our department to determine the proportion of basal cell nevus syndrome among multiple cystic lesions. Methods. Patients who had a panoramic radiograph taken at Okayama University Hospital between 1993 and 2000 were examined. Twenty-three patients with multiple cystic jaw lesions on a first panoramic radiography examination were entered into this study. Results. Of the 23 patients, 12 (52.2%) were diagnosed with basal cell nevus syndrome and 11 (47.8%) were not. Of the 14 patients with multiple KOTs, 12 (85.7%) were diagnosed as having basal cell nevus syndrome. Of the nine remaining patients with multiple cystic jaw lesions, only seven had multiple dentigerous cysts and two had multiple simple bone cysts. Cleft palate was observed in four of the 12 patients (33.3%) with basal cell nevus syndrome. Conclusion. Diagnosing basal cell nevus syndrome based on multiple cystic jaw lesions carries a high risk of misdiagnosis. A strong possibility exists that patients with multiple jaw KOTs have basal cell nevus syndrome. Furthermore, cleft palate should be considered an important oral finding in basal cell nevus syndrome because its occurrence was relatively frequent in our study. © 2007 Japanese Society for Oral and Maxillofacial Radiology Springer-Verlag.

    DOI: 10.1007/s11282-007-0059-x

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  • Novel cell-surface peptides specific to human oral squamous cell carcinoma using an E-coli peptide display library

    Noriko Kawai, Junichi Asaumi, Jun Murakami, Toru Wakasa, Masahiro Kuroda, Miki Hisatomi, Teruhisa Unetsubo, Yuu Maki, Hidenobu Matsuzaki, Yoshinonu Yanagi, Hironobu Konouchi

    ONCOLOGY REPORTS   17 ( 4 )   787 - 791   2007年4月

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    記述言語:英語   出版者・発行元:PROFESSOR D A SPANDIDOS  

    We attempted to find a specific antigen of oral squamous cell carcinoma (SCC) cells that could be safely applied to gene therapy in the conservative clinical treatment of oral cancer. We performed subtraction using normal human keratinocyte cells, followed by selection using four oral SCC cell lines. We isolated three clones from poorly differentiated SCC cells and four from well-differentiated SCC cells. These seven clones adsorbed to the oral SCC cells at rates 10-100 times those of normal human keratinocyte cells. The three clones from the poorly differentiated SCC cells showed the same peptide sequence (LAPRTHP). Of the four clones from the well-differentiated SCC cells, three showed the same peptide sequence (FGTLPGT) and the fourth showed a different one (VTPNSTP). Each peptide sequence may recognize the material that exists specifically on the oral SCC cell cortex. We can expect applications not only for tumor-targeting treatment using a gene therapy virus vector but also for diagnosis using, as a tumor marker, the peculiar SCC surface material that these peptides recognize.

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  • 放射線治療後の口腔乾燥症に対し,塩酸ピロカルピン(サラジェン?)を投与しフッ素塗布を用いた口腔ケアを行った2症例.

    水川展吉, 山中玲子, 山本龍生, 松﨑秀信, 浅海淳一, 山近英樹, 植野高章, 高木慎, 菅原利夫

    岡山歯学会雑誌   26 ( 2 )   129 - 134   2007年

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  • 硬口蓋全体に進展した扁平上皮癌に対してマイクロセレクトロンHDRを用いたモールド治療法により治癒した一例.

    浅海淳一, 松﨑秀信, 武本充広, 木村卓爾, 佐々木朗, 金澤右

    岡山歯学会雑誌   26 ( 2 )   135 - 139   2007年

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  • Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells

    Keiji Matsuda, Shin-Ya Nakagawa, Tomoya Nakano, Jun-Ichi Asaumi, Ganesh Chandra Jagetia, Shoji Kawasaki

    INTERNATIONAL JOURNAL OF HYPERTHERMIA   22 ( 8 )   729 - 735   2006年12月

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS LTD  

    Purpose: Methylation of H3 at lysine 4 (H3 Lys4) may be correlated with active gene trascription, whereas methylation of H3 at lysine 9 (H3 Lys9) may be linked to gene repression in murine cells and Schizosaccharomyces pombe.
    Methods: Using Western blot analysis, heat-induced changes were studied in two human oral cancer cell lines, HSC4 (thermoresistant cells) and KB (thermosensitive cells). Histone H3 changes were studied; in particular for H3-Lys4 and H3-Lys9 methylation combined with KNK437.
    Results: Heating of HSC4 cells at 45 degrees C for 20 min and KB cells for 3 min gradually increased H3-Lys4 and H3-Lys9 methylation. Treatment of both cells with 100 JAM KNK437 before or after heat-treatment inhibited methylation of H3-Lys4, while methylation of H3 Lys9 remained unaffected. Use of KNK437 either before or after heat treatment inhibited the expression of HSP70.
    Conclusions:: The findings suggest that heat-induced methylation of histone H3 may be correlated with the induction of HSPs by heating.

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  • Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells

    Keiji Matsuda, Shin-Ya Nakagawa, Tomoya Nakano, Jun-Ichi Asaumi, Ganesh Chandra Jagetia, Shoji Kawasaki

    INTERNATIONAL JOURNAL OF HYPERTHERMIA   22 ( 8 )   729 - 735   2006年12月

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS LTD  

    Purpose: Methylation of H3 at lysine 4 (H3 Lys4) may be correlated with active gene trascription, whereas methylation of H3 at lysine 9 (H3 Lys9) may be linked to gene repression in murine cells and Schizosaccharomyces pombe.
    Methods: Using Western blot analysis, heat-induced changes were studied in two human oral cancer cell lines, HSC4 (thermoresistant cells) and KB (thermosensitive cells). Histone H3 changes were studied; in particular for H3-Lys4 and H3-Lys9 methylation combined with KNK437.
    Results: Heating of HSC4 cells at 45 degrees C for 20 min and KB cells for 3 min gradually increased H3-Lys4 and H3-Lys9 methylation. Treatment of both cells with 100 JAM KNK437 before or after heat-treatment inhibited methylation of H3-Lys4, while methylation of H3 Lys9 remained unaffected. Use of KNK437 either before or after heat treatment inhibited the expression of HSP70.
    Conclusions:: The findings suggest that heat-induced methylation of histone H3 may be correlated with the induction of HSPs by heating.

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  • Enhancement effects of test injection with a small amount of MR contrast medium in the oral and maxillofacial region

    Yoshinobu Yanagi, Jun-ichi Asaumi, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Jun Murakami, Yuu Maki, Teruhisa Unetsubo, Kanji Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   59 ( 3 )   367 - 370   2006年9月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    Purpose: To examine whether the signal intensity of dynamic contrast-enhanced MRI (DCE-MRI) is altered by test injection of 1 ml of contrast medium, and if so, whether this change affects the DCE-MRI analysis.
    Materials and methods: Six healthy volunteers were examined by DCE-MRI using a Magnevist syringe and/or an Omniscan syringe for the injection of contrast medium. Each scan was performed 10 times using steady-state free precession (3D-FISP), a sequence for DCE-MRI, before and after intravenous injection of 1 ml of the contrast medium. The internal pterygoid muscle, masseter muscle, tongue, parotid gland, submandibular gland, bone marrow of the mandible, subcutaneous adipose tissue, and common carotid artery were determined to be regions of interest (ROI), and the ROI internal average signal intensity was measured. The 10 data sets obtained before or after contrast medium administration for each ROI were evaluated using the paired t-test.
    Results: The test injection increased the signal intensities of six of eight ROIs, with all 20 experiments in the submandibular gland showing significant differences. There was no significant difference in the two ROIs corresponding to the carotid artery and subcutaneous adipose tissue of the cheek.
    Conclusions: The enhanced signal intensity in the tissue might have been caused by the small amount of contrast medium in the test injection. To eliminate this discrepancy caused by the test injection, a pre-contrast scan should be performed when the average signal intensity of an ROI is measured. We therefore believe that the data obtained before a test injection may be important in the analysis of DCE-MRI. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ejrad.2006.03.017

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  • Enhancement effects of test injection with a small amount of MR contrast medium in the oral and maxillofacial region

    Yoshinobu Yanagi, Jun-ichi Asaumi, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Jun Murakami, Yuu Maki, Teruhisa Unetsubo, Kanji Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   59 ( 3 )   367 - 370   2006年9月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    Purpose: To examine whether the signal intensity of dynamic contrast-enhanced MRI (DCE-MRI) is altered by test injection of 1 ml of contrast medium, and if so, whether this change affects the DCE-MRI analysis.
    Materials and methods: Six healthy volunteers were examined by DCE-MRI using a Magnevist syringe and/or an Omniscan syringe for the injection of contrast medium. Each scan was performed 10 times using steady-state free precession (3D-FISP), a sequence for DCE-MRI, before and after intravenous injection of 1 ml of the contrast medium. The internal pterygoid muscle, masseter muscle, tongue, parotid gland, submandibular gland, bone marrow of the mandible, subcutaneous adipose tissue, and common carotid artery were determined to be regions of interest (ROI), and the ROI internal average signal intensity was measured. The 10 data sets obtained before or after contrast medium administration for each ROI were evaluated using the paired t-test.
    Results: The test injection increased the signal intensities of six of eight ROIs, with all 20 experiments in the submandibular gland showing significant differences. There was no significant difference in the two ROIs corresponding to the carotid artery and subcutaneous adipose tissue of the cheek.
    Conclusions: The enhanced signal intensity in the tissue might have been caused by the small amount of contrast medium in the test injection. To eliminate this discrepancy caused by the test injection, a pre-contrast scan should be performed when the average signal intensity of an ROI is measured. We therefore believe that the data obtained before a test injection may be important in the analysis of DCE-MRI. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

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  • Usefulness of contrast enhanced-MRI in the diagnosis of unicystic ameloblastoma

    H Konouchi, JI Asaumi, Y Yanagi, M Hisatomi, N Kawai, H Matsuzaki, K Kishi

    ORAL ONCOLOGY   42 ( 5 )   481 - 486   2006年5月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The radiographic features of unicystic ameloblastoma (UA) are typically unilocular and round area of radiolucency. Therefore, this type of lesion is often misdiagnosed as an odontogenic keratocyst or a dentigerous cyst. UA should be differentiated from odontogenic cysts because the former have a higher rate of recurrence than the latter. In the present study, we performed contrast enhanced-MRI (CE-MRI) to diagnose 13 cases of unilocular, round radiolucent lesions visualized on panoramic radiograph and/or CT. In the cases of UA, low signal intensity was observed on T1-weighted images (WIs), and a markedly high signal intensity was observed on T2-WIs; moreover, relatively thick rim-enhancement with/without small intraluminal nodules was observed upon CE-T1 WIs. CE-MRI was considered useful in the diagnosis of UA, as characteristic features of this type of Lesion i.e., thick enhancement of the tumor wall and small intraluminal nodules were detected only by CE-MRI in the present study. (c) 2005 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.oraloncology.2005.10.001

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  • Usefulness of contrast enhanced-MRI in the diagnosis of unicystic ameloblastoma

    H Konouchi, JI Asaumi, Y Yanagi, M Hisatomi, N Kawai, H Matsuzaki, K Kishi

    ORAL ONCOLOGY   42 ( 5 )   481 - 486   2006年5月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The radiographic features of unicystic ameloblastoma (UA) are typically unilocular and round area of radiolucency. Therefore, this type of lesion is often misdiagnosed as an odontogenic keratocyst or a dentigerous cyst. UA should be differentiated from odontogenic cysts because the former have a higher rate of recurrence than the latter. In the present study, we performed contrast enhanced-MRI (CE-MRI) to diagnose 13 cases of unilocular, round radiolucent lesions visualized on panoramic radiograph and/or CT. In the cases of UA, low signal intensity was observed on T1-weighted images (WIs), and a markedly high signal intensity was observed on T2-WIs; moreover, relatively thick rim-enhancement with/without small intraluminal nodules was observed upon CE-T1 WIs. CE-MRI was considered useful in the diagnosis of UA, as characteristic features of this type of Lesion i.e., thick enhancement of the tumor wall and small intraluminal nodules were detected only by CE-MRI in the present study. (c) 2005 Elsevier Ltd. All rights reserved.

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  • Clinical and radiographic presentation and preparation of the prototyping model for pre-surgical planning in Apert's syndrome

    EK Sannomiya, SAB Reis, J Asaumi, JVL Silva, AS Barbara, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   35 ( 2 )   119 - 124   2006年3月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    Acrocephalosyndactyly, or Apert's syndrome, described nearly a century ago, is a craniofacial dysostosis, an autosomal dominant condition characterized by severe development disturbances of the craniofacial region including bilateral coronal synostosis associated with midface hypoplasia, exophthalmia, hypertelorism, Symmetric syndactyly of the hands and feet, cone-shaped calvarium, pharyngeal attenuation and malocclusion. The aim of this Study was to assess clinical and computed tomography (CT) imaging patterns of a non-operated patient with Apert's syndrome, correlating the cranium, face and the skull base bone abnormalities. Three-dimensional images were generated from spiral CT scans in order to produce a prototyping model in polyamide material. Clinical examination determined that syndactyly of the hands and feet, pseudocleft in the midline palate and midface hypoplasia were present. The surgical model allowed the analysis of some abnormalities regarding to calvaria morphology, nasal bones and maxilla, improving the criteria for a case diagnosis and surgical plan.

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  • Clinical and radiographic presentation and preparation of the prototyping model for pre-surgical planning in Apert's syndrome

    EK Sannomiya, SAB Reis, J Asaumi, JVL Silva, AS Barbara, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   35 ( 2 )   119 - 124   2006年3月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    Acrocephalosyndactyly, or Apert's syndrome, described nearly a century ago, is a craniofacial dysostosis, an autosomal dominant condition characterized by severe development disturbances of the craniofacial region including bilateral coronal synostosis associated with midface hypoplasia, exophthalmia, hypertelorism, Symmetric syndactyly of the hands and feet, cone-shaped calvarium, pharyngeal attenuation and malocclusion. The aim of this Study was to assess clinical and computed tomography (CT) imaging patterns of a non-operated patient with Apert's syndrome, correlating the cranium, face and the skull base bone abnormalities. Three-dimensional images were generated from spiral CT scans in order to produce a prototyping model in polyamide material. Clinical examination determined that syndactyly of the hands and feet, pseudocleft in the midline palate and midface hypoplasia were present. The surgical model allowed the analysis of some abnormalities regarding to calvaria morphology, nasal bones and maxilla, improving the criteria for a case diagnosis and surgical plan.

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  • A case of recurrent ameloblastoma developing in an autogenous iliac bone graft 20 years after the initial treatment

    YS Choi, J Asaumi, Y Yanagi, M Hisatomi, H Konouchi, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   35 ( 1 )   43 - 46   2006年1月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    A case of recurrent ameloblastoma developing in an autogenous iliac bone graft 20 years after radical resection of primary mandibular ameloblastoma is presented. This case showed extensive bony resorption extending throughout the auto-grafted bone. Seeding to the graft bone was suspected as a cause of the recurrence in the iliac bone graft because wide destruction of the graft bone was observed without any prior signs and symptoms of intraoral mucosa. Consequently, extensive resection of bone as well as adjacent soft tissue was performed. Persistent follow-up examination is essential for management of ameloblastoma.

    DOI: 10.1259/dmfr/13828255

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  • A case of recurrent ameloblastoma developing in an autogenous iliac bone graft 20 years after the initial treatment

    YS Choi, J Asaumi, Y Yanagi, M Hisatomi, H Konouchi, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   35 ( 1 )   43 - 46   2006年1月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    A case of recurrent ameloblastoma developing in an autogenous iliac bone graft 20 years after radical resection of primary mandibular ameloblastoma is presented. This case showed extensive bony resorption extending throughout the auto-grafted bone. Seeding to the graft bone was suspected as a cause of the recurrence in the iliac bone graft because wide destruction of the graft bone was observed without any prior signs and symptoms of intraoral mucosa. Consequently, extensive resection of bone as well as adjacent soft tissue was performed. Persistent follow-up examination is essential for management of ameloblastoma.

    DOI: 10.1259/dmfr/13828255

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  • Microcystic Adnexal Carcinoma with Mandibular Bone Marrow Involvement: A Case Report with Immunohistochemistry

    Nagatsuka Hitoshi, Rivera Rosario Santos, Gunduz Mehmet, Siar Chong Huat, FDSRCPS FRCPath, Tamamura Ryo, Mizukawa Nobuyoshi, Asaumi Junichi, Nagai Noriyuki

    Am J Dermatopathol   2006年

  • Microcystic adnexal carcinoma with mandibular bone marrow involvement: a case report with immunohistochemistry.

    Nagatsuka H, Rivera RS, Gunduz M, Siar CH, Tamamura R, Mizukawa N, Asaumi J, Nagai N

    Am J Dermatopathol   2006年

  • A benzylidene lactam, KNK437 inhibits the ecpression of heat shock proteins in human oral cancer cell lines exposed to hyperthermia

    Shin-ya Nakagawa, Keiji Matsuda, Tomoya Nakano, Ganesh Chandrs Jagetia, Jun-ichi Asaumi, Shoji Kawasaki

    Jpn J Hyperthermic Oncol   2006年

  • A benzylidene lactam, KNK437 inhibits the ecpression of heat shock proteins in human oral cancer cell lines exposed to hyperthermia.

    Nakagawa S, Matsuda K, Nakano T, Jagetia GC, Asaumi J, Kawasaki S

    Jpn J Hyperthermic Oncol   2006年

  • Role of O-6-methylguanine-DNA methyltransferase and effect of O-6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines

    Y Maki, J Murakami, J Asaumi, H Tsujigiwa, H Nagatsuka, S Kokeguchi, K Fukui, N Kawai, Y Yanagi, M Kuroda, N Tanaka, N Matsubara, K Kishi

    ORAL ONCOLOGY   41 ( 10 )   984 - 993   2005年11月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The DNA repair enzyme, O-6-methylguanine-DNA methyltransferase (MGMT) modulates the effectiveness of alkylating agents. However, the relationship between MGMT and the sensitivities to other agents has not been explored. In the present study, the association between MGMT expression and the cellular sensitivity to the platinum agent, CDDP was examined in four human oral cancer cell tines. CDDP depleted MGMT protein and mRNA levels in all four cell tines. Two cell lines with low MGMT expression were sensitive to an alkylating agent, N-methyl-N'-nitro-N-nitrosoguanidine and CDDP, whereas two other cell tines with high MGMT expression were resistant to both agents. Furthermore, the addition of the MGMT inhibitor, O-6-benzylguanine (O-6-BG), invariably enhanced CDDP sensitivity. CDDP depleted MGMT expression, and CDDP sensitivity was enhanced by O-6-BG. These results provide valuable information about the relationship between MGMT expression and CDDP sensitivity in oral cancer chemotherapy. (c) 2005 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.oraloncology.2005.05.011

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  • Bone deformity showing a deep coronoid notch of the mandible in a patient with neurofibromatosis type 1

    M Hisatomi, J Asaumi, H Konouchi, Y Yanagi, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   34 ( 6 )   380 - 383   2005年11月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    We present a case of a 10-year-old girl with neurofibromatosis type I related skeletal dysplasia. In the present case, a unilocular radiolucency at the left coronoid notch visible on a panoramic radiograph was suspected to be a neurofibroma. However, only the presence of bone deformities was observed on CT. Fat-like tissue adjacent to the bone deformities inside the left mandibular ramus was revealed, and the presence of neurofibroma was unequivocally denied on the MR images. However, biopsy of the lesion suggested neurofibroma. The diagnostic imaging 18 months after the first visit did not revealed a tumourous mass. However, careful follow up is required even though we could not prove the presence the lesion on the basis of imaging.

    DOI: 10.1259/dmfr/46427075

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  • Role of O6-methylguanine–DNA methyltransferase and effect of O6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines.

    Yu Maki, Jun Murakami, Jun-ichi Asaumi, Hidetsugu Tsujigiwa, Hitoshi Nagatsuka, Susumu Kokeguchi, Kazuhiro Fukui, Noriko Kawai, Yoshinobu Yanagi, Masahiro Kuroda, Noriaki Tanaka

    Oral Oncol.   41 ( 10 )   984 - 993   2005年11月

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  • Assessment of ameloblastomas using MRI and dynamic contrast-enhanced MRI

    J Asaumi, M Hisatomi, Y Yanagi, H Matsuzaki, YS Choi, N Kawai, H Konouchi, K Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   56 ( 1 )   25 - 30   2005年10月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    We retrospectively evaluated magnetic resonance images (MRI) and dynamic contrast-enhanced MRI (DCE-MRI) of ameloblastomas. MRI and DCE-MRI were performed for 10 ameloblastomas.
    We obtained the following results from the MRI and DCE-MRI. (a) Ameloblastomas can be divided into solid and cystic portions on the basis of MR signal intensities. (b) Ameloblastomas show a predilection for intermediate signal intensity on T1WI, high signal intensity on T2WI, and well enhancement in the solid portion; they also show a homogeneous intermediate signal intensity on T1WI and homogeneous high signal intensity on T2WI, and no enhancement in the cystic portion. (c) The mural nodule or thick wall can be detected in ameloblastomas lesions. (d) CI curves of ameloblastomas show two patterns: the first pattern increases, reaches a plateau at 100-300 s, then sustains the plateau or decreases gradually to 600-900 s, while the other increases relatively rapidly, reaches a plateau at 90-120 s, then decreases relatively rapidly to 300 s, and decreases gradually thereafter. There was no difference in the Cl curve patterns among primary and recurrent cases, a case with glandular odontogenic tumor in ameloblastoma. or among histopathological types such as plexiform, follicular, mixed, desmoplastic, and unicystic type. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ejrad.2005.01.006

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  • Assessment of ameloblastomas using MRI and dynamic contrast-enhanced MRI

    J Asaumi, M Hisatomi, Y Yanagi, H Matsuzaki, YS Choi, N Kawai, H Konouchi, K Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   56 ( 1 )   25 - 30   2005年10月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    We retrospectively evaluated magnetic resonance images (MRI) and dynamic contrast-enhanced MRI (DCE-MRI) of ameloblastomas. MRI and DCE-MRI were performed for 10 ameloblastomas.
    We obtained the following results from the MRI and DCE-MRI. (a) Ameloblastomas can be divided into solid and cystic portions on the basis of MR signal intensities. (b) Ameloblastomas show a predilection for intermediate signal intensity on T1WI, high signal intensity on T2WI, and well enhancement in the solid portion; they also show a homogeneous intermediate signal intensity on T1WI and homogeneous high signal intensity on T2WI, and no enhancement in the cystic portion. (c) The mural nodule or thick wall can be detected in ameloblastomas lesions. (d) CI curves of ameloblastomas show two patterns: the first pattern increases, reaches a plateau at 100-300 s, then sustains the plateau or decreases gradually to 600-900 s, while the other increases relatively rapidly, reaches a plateau at 90-120 s, then decreases relatively rapidly to 300 s, and decreases gradually thereafter. There was no difference in the Cl curve patterns among primary and recurrent cases, a case with glandular odontogenic tumor in ameloblastoma. or among histopathological types such as plexiform, follicular, mixed, desmoplastic, and unicystic type. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

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  • Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer

    J Murakami, J Asaumi, N Kawai, H Tsujigiwa, Y Yanagi, H Nagatsuka, T Inoue, S Kokeguchi, S Kawasaki, M Kuroda, N Tanaka, N Matsubara, K Kishi

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   56 ( 1 )   22 - 28   2005年7月

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    記述言語:英語   出版者・発行元:SPRINGER  

    We speculated whether or not the expression level of telomerase reverse transcriptase (hTERT) would be modulated by agents targeting epigenetics in oral cancer cell lines. Although hTERT is known to be targeted by epigenetic changes, it remains unclear how chemoagents targeting epigenetics work on hTERT transcription. In the present study, the epigenetic effects of the histone deacetylase (HDAC) inhibitor FR901228 on hTERT transcription in oral cancer cell lines were analyzed by RT-PCR. The mRNA expression of hTERT was upregulated after exposure to FR901228 in hTERT-negative Hep2 cells, and even SAS and KB cells expressed high levels of hTERT. Moreover, cotreatment of protein synthesis inhibitor cycloheximide (CHX) resulted in the induction of hTERT transcription by FR901228. This suggests that the induction of hTERT by FR901228 requires de novo protein synthesis to some extent and is more likely a direct than an indirect effect on epigenetic changes such as histone acetylation/deacetylation. We further examined the effect of FR901228 on c-myc protein, which is one of the main hTERT transcription activators. FR901228 repressed c-myc protein only in the absence of CHX, and depended on the enhancement of de novo protein synthesis. Our results indicate that c-myc protein is repressed indirectly by FR901228 but may not contribute to FR901228-induced hTERT transcription. The present study showed that the HDAC inhibitor FR901228 induced the hTERT gene by a complex mechanism that involved transcription factors other than c-myc, in addition to inhibition of histone deacetylation.

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  • Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer

    J Murakami, J Asaumi, N Kawai, H Tsujigiwa, Y Yanagi, H Nagatsuka, T Inoue, S Kokeguchi, S Kawasaki, M Kuroda, N Tanaka, N Matsubara, K Kishi

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   56 ( 1 )   22 - 28   2005年7月

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    記述言語:英語   出版者・発行元:SPRINGER  

    We speculated whether or not the expression level of telomerase reverse transcriptase (hTERT) would be modulated by agents targeting epigenetics in oral cancer cell lines. Although hTERT is known to be targeted by epigenetic changes, it remains unclear how chemoagents targeting epigenetics work on hTERT transcription. In the present study, the epigenetic effects of the histone deacetylase (HDAC) inhibitor FR901228 on hTERT transcription in oral cancer cell lines were analyzed by RT-PCR. The mRNA expression of hTERT was upregulated after exposure to FR901228 in hTERT-negative Hep2 cells, and even SAS and KB cells expressed high levels of hTERT. Moreover, cotreatment of protein synthesis inhibitor cycloheximide (CHX) resulted in the induction of hTERT transcription by FR901228. This suggests that the induction of hTERT by FR901228 requires de novo protein synthesis to some extent and is more likely a direct than an indirect effect on epigenetic changes such as histone acetylation/deacetylation. We further examined the effect of FR901228 on c-myc protein, which is one of the main hTERT transcription activators. FR901228 repressed c-myc protein only in the absence of CHX, and depended on the enhancement of de novo protein synthesis. Our results indicate that c-myc protein is repressed indirectly by FR901228 but may not contribute to FR901228-induced hTERT transcription. The present study showed that the HDAC inhibitor FR901228 induced the hTERT gene by a complex mechanism that involved transcription factors other than c-myc, in addition to inhibition of histone deacetylation.

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  • Assessment of lesions arising or extending in the submental region with magnetic resonance imaging

    Jun-Ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Hironobu Konouchi, Hidenobu Matsuzaki, Kanji Kishi

    Oral Radiology   21 ( 1 )   6 - 13   2005年6月

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    記述言語:英語  

    Objectives. Various types of lesion have been reported in the submental region, but submental masses can be difficult to diagnose. Our objective was to attempt to diagnose submental masses by using magnetic resonance imaging (MRI) along with clinical data. Methods. We attempted to diagnose seven cases in which the chief complaint was submental swelling
    diagnosis was carried out on the basis of features visualized by MRI. Results. Seven types of lesions were observed: phlegmone and abscess caused by osteomyelitis
    epidermoid cyst
    thyroglossal duct cyst
    abscess-forming granulomatous lymphadenitis
    T-cell lymphoma (suspected Hodgkin's disease)
    non-Hodgkin's B-cell lymphoma
    and lymph node metastasis from squamous cell carcinoma in the tongue. Conclusions. The magnetic resonance images of each lesion revealed characteristic features. Thus, MRI may be useful for the differential diagnosis of submental swelling before the initiation of treatment. © Japanese Society for Oral and Maxillofacial Radiology Springer-Verlag Tokyo 2005.

    DOI: 10.1007/s11282-004-0021-0

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  • Assessment of lesions arising or extending in the submental region with magnetic resonance imaging

    Jun-Ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Hironobu Konouchi, Hidenobu Matsuzaki, Kanji Kishi

    Oral Radiology   21 ( 1 )   6 - 13   2005年6月

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    記述言語:英語  

    Objectives. Various types of lesion have been reported in the submental region, but submental masses can be difficult to diagnose. Our objective was to attempt to diagnose submental masses by using magnetic resonance imaging (MRI) along with clinical data. Methods. We attempted to diagnose seven cases in which the chief complaint was submental swelling
    diagnosis was carried out on the basis of features visualized by MRI. Results. Seven types of lesions were observed: phlegmone and abscess caused by osteomyelitis
    epidermoid cyst
    thyroglossal duct cyst
    abscess-forming granulomatous lymphadenitis
    T-cell lymphoma (suspected Hodgkin's disease)
    non-Hodgkin's B-cell lymphoma
    and lymph node metastasis from squamous cell carcinoma in the tongue. Conclusions. The magnetic resonance images of each lesion revealed characteristic features. Thus, MRI may be useful for the differential diagnosis of submental swelling before the initiation of treatment. © Japanese Society for Oral and Maxillofacial Radiology Springer-Verlag Tokyo 2005.

    DOI: 10.1007/s11282-004-0021-0

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  • 嚥下時における舌圧と咽頭内圧の関連についてー舌圧・咽頭内圧測定システムの構築―

    有岡享子, 石田 瞭, 柳 文修, 浅海淳一, 江草正彦, 嶋田昌彦, 岸 幹二

    岡山歯学   2005年

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  • Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line.

    Int J Oncol   26(4):853-62   2005年

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  • Hydrogen peroxide overload increases adriamycin-induced apoptosis of SaOS(2)FM, a manganese superoxide dismutase-overexpressing human osteosarcoma cell line.

    Wang Y, Kuroda M, Gao XS, Asaumi J, Shibuya K, Kawasaki S, Akaki S, St Clair D, Hiraki Y, Kanazawa S

    Int J Oncol   2005年

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  • Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line.

    Komatsu M, Kuroda M, Wang Y, St Clair D, Urano M, Akaki S, Asaumi J, Kawasaki S, Hiraki Y, Kanazawa S

    Int J Oncol   2005年

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  • Development of a new hybrid gel phantom using carrageenan and gellan gum for visualizing three-dimensional temperature distribution during hyperthermia and radiofrequency ablation.

    Int J Oncol.   27(1):175-84.   2005年

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  • Hydrogen peroxide overload increases adriamycin-induced apoptosis of SaOS(2)FM, a manganese superoxide dismutase-overexpressing human osteosarcoma cell line.

    Int J Oncol.   26(5);1291-300   2005年

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  • 好酸球肉芽腫の臨床的・X線学的検討

    浅海淳一, 畦坪輝寿, 牧 優, 村上 純, 松﨑秀信, 久富美紀, 河井紀子, 柳 文修, 此内浩信, 岸 幹二

    岡山歯学   2005年

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  • Erdheim-Chester disease in a child presenting with multiple jaw lesions.

    Nagatsuka H, Han PP, Taguchi K, Tsujigiwa H, Gunduz M, Fukunaga J, Sugahara T, Asaumi J, Nagai N, Erdheim-Chester disease in a child, presenting with multiple jaw lesions

    J Oral Pathol Med.   2005年

  • Erdheim-Chester disease in a child presenting with multiple jaw lesions.

    J Oral Pathol Med.   34(7):420-2.   2005年

  • Development of a new hybrid gel phantom using carrageenan and gellan gum for visualizing three-dimensional temperature distribution during hyperthermia and radiofrequency ablation.

    Kuroda M, Kato H, Hanamoto K, Shimamura K, Uchida T, Wang Y, Akaki S, Asaumi J, Himei K, Takemoto M, Kanazawa S, Shibuya K, Kawasaki S, Hiraki Y

    Int J Oncol.   2005年

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  • Assessment of MRI and dynamic contrast-enhanced MRI in the differential diagnosis of adenomatoid odontogenic tumor

    J Asaumi, Y Yanagi, H Konouchi, M Hisatomi, H Matsuzaki, H Shigehara, K Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   51 ( 3 )   252 - 256   2004年9月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    The radiographical differentiation of adenomatoid odontogenic tumor (AOT) from dentigerous cysts, calcifying odontogenic cysts, calcifying epithelial odontogenic tumors, odontogenic keratocysts and amelobastomas is sometimes difficult. We attempted to differentiate AOT from other lesions similar to AOT in radiographic findings using MRI. The MRI features of AOT in our three cases included homogeneous low SI in the cystic portion and homogeneous intermediate SI in the solid portion on T1WI, homogeneous high SI in the cystic portion and intermediate to slightly high SI in the solid portion on T2WI and enhancement of only the solid portion on CE-T1WI although none of the sequences included SI of calcifications. The contrast index curves in the three cases of AOT showed a gradual increase to 300 s, which signified a benign tumor. These MRI features were characteristic features of AOT and might be a basis for differentiating AOT from the above possible lesions in radiographic examinations. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

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  • Assessment of MRI and dynamic contrast-enhanced MRI in the differential diagnosis of adenomatoid odontogenic tumor

    J Asaumi, Y Yanagi, H Konouchi, M Hisatomi, H Matsuzaki, H Shigehara, K Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   51 ( 3 )   252 - 256   2004年9月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    The radiographical differentiation of adenomatoid odontogenic tumor (AOT) from dentigerous cysts, calcifying odontogenic cysts, calcifying epithelial odontogenic tumors, odontogenic keratocysts and amelobastomas is sometimes difficult. We attempted to differentiate AOT from other lesions similar to AOT in radiographic findings using MRI. The MRI features of AOT in our three cases included homogeneous low SI in the cystic portion and homogeneous intermediate SI in the solid portion on T1WI, homogeneous high SI in the cystic portion and intermediate to slightly high SI in the solid portion on T2WI and enhancement of only the solid portion on CE-T1WI although none of the sequences included SI of calcifications. The contrast index curves in the three cases of AOT showed a gradual increase to 300 s, which signified a benign tumor. These MRI features were characteristic features of AOT and might be a basis for differentiating AOT from the above possible lesions in radiographic examinations. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

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  • Assessment of MRI and dynamic contrast-enhanced MRI in the differential diagnosis of adenomatoid odontogenic tumor

    J Asaumi, Y Yanagi, H Konouchi, M Hisatomi, H Matsuzaki, H Shigehara, K Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   51 ( 3 )   252 - 256   2004年9月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    The radiographical differentiation of adenomatoid odontogenic tumor (AOT) from dentigerous cysts, calcifying odontogenic cysts, calcifying epithelial odontogenic tumors, odontogenic keratocysts and amelobastomas is sometimes difficult. We attempted to differentiate AOT from other lesions similar to AOT in radiographic findings using MRI. The MRI features of AOT in our three cases included homogeneous low SI in the cystic portion and homogeneous intermediate SI in the solid portion on T1WI, homogeneous high SI in the cystic portion and intermediate to slightly high SI in the solid portion on T2WI and enhancement of only the solid portion on CE-T1WI although none of the sequences included SI of calcifications. The contrast index curves in the three cases of AOT showed a gradual increase to 300 s, which signified a benign tumor. These MRI features were characteristic features of AOT and might be a basis for differentiating AOT from the above possible lesions in radiographic examinations. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

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  • Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck

    J Asaumi, Y Yanagi, H Konouchi, M Hisatomi, H Matsuzaki, K Kishi

    ORAL ONCOLOGY   40 ( 6 )   579 - 584   2004年7月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI.
    Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum Cl at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant Lymphoma in the time needed reach the maximum CI (p = 0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum Cls (p < 0.001), with the maximum Cls of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed Cis of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs. (C) 2003 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.oraloncology.2003.12.002

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  • Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck

    J Asaumi, Y Yanagi, H Konouchi, M Hisatomi, H Matsuzaki, K Kishi

    ORAL ONCOLOGY   40 ( 6 )   579 - 584   2004年7月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI.
    Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum Cl at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant Lymphoma in the time needed reach the maximum CI (p = 0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum Cls (p < 0.001), with the maximum Cls of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed Cis of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs. (C) 2003 Elsevier Ltd. All rights reserved.

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  • Effects of demethylating agent 5-aza-2 '-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cancer cell lines

    J Murakami, J Asaumi, Y Maki, H Tsujigiwa, M Kuroda, N Nagai, Y Yanagi, T Inoue, S Kawasaki, N Tanaka, N Matsubara, K Kishi

    ORAL ONCOLOGY   40 ( 6 )   597 - 603   2004年7月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Maspin, which belongs to the serine protease inhibitor (serpin) superfamily, has been proposed as a potent tumor suppressor that inhibits cell motility, invasion, angiogenesis, and metastasis. In the present study, we examined the effects of 5-aza-2'-deoxycytidine (5-aza-dC), a demethylating agent, and FR901228, a histone deacetylase (HDAC) inhibitor, on maspin expression in oral cancer cell tines. The expression levels of maspin mRNA were divided into two groups, which was the maspin tow-expressed and high-expressed cell lines in the 12 oral cancer cell lines. The maspin promoter contained only a few methylated CpG sites in the maspin low-expressed cell lines. Moreover, the methylation status was not altered after 5-aza-dC treatment. However, the transcription of the maspin gene was clearly increased following 5-aza-dC treatment in a number of oral cancer cell tines. These results imply that an action of 5-aza-dC is separate from induction of promoter demethylation. Treatment with FR901228 resulted in a time-dependent stimulation of the re-expression of maspin mRNA as early as 4 h after treatment in the maspin downregulated cells. The re-expression of the maspin gene may contribute to the recuperation of biological functions linked to FR901228 such as an inhibitory effect on tumor angiogenesis and cell invasion. These results indicate that maspin and its target genes may be excellent leads for future studies on the potential benefits of FR901228, a HDAC inhibitor, in cancer therapy. (C) 2004 Elsevier Ltd. All rights reserved.

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  • Effects of demethylating agent 5-aza-2 '-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cancer cell lines

    J Murakami, J Asaumi, Y Maki, H Tsujigiwa, M Kuroda, N Nagai, Y Yanagi, T Inoue, S Kawasaki, N Tanaka, N Matsubara, K Kishi

    ORAL ONCOLOGY   40 ( 6 )   597 - 603   2004年7月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Maspin, which belongs to the serine protease inhibitor (serpin) superfamily, has been proposed as a potent tumor suppressor that inhibits cell motility, invasion, angiogenesis, and metastasis. In the present study, we examined the effects of 5-aza-2'-deoxycytidine (5-aza-dC), a demethylating agent, and FR901228, a histone deacetylase (HDAC) inhibitor, on maspin expression in oral cancer cell tines. The expression levels of maspin mRNA were divided into two groups, which was the maspin tow-expressed and high-expressed cell lines in the 12 oral cancer cell lines. The maspin promoter contained only a few methylated CpG sites in the maspin low-expressed cell lines. Moreover, the methylation status was not altered after 5-aza-dC treatment. However, the transcription of the maspin gene was clearly increased following 5-aza-dC treatment in a number of oral cancer cell tines. These results imply that an action of 5-aza-dC is separate from induction of promoter demethylation. Treatment with FR901228 resulted in a time-dependent stimulation of the re-expression of maspin mRNA as early as 4 h after treatment in the maspin downregulated cells. The re-expression of the maspin gene may contribute to the recuperation of biological functions linked to FR901228 such as an inhibitory effect on tumor angiogenesis and cell invasion. These results indicate that maspin and its target genes may be excellent leads for future studies on the potential benefits of FR901228, a HDAC inhibitor, in cancer therapy. (C) 2004 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.oraloncology.2003.12.008

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  • Radiographic examination of mesiodens and their associated complications

    JI Asaumi, Y Shibata, Y Yanagi, M Hisatomi, H Matsuzaki, H Konouchi, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   33 ( 2 )   125 - 127   2004年3月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    Objectives: To examine mesiodens with regard to their status, their influence on adjacent teeth and their alteration during the follow-up period.
    Methods: From retrospective reviews of all patients who visited our institution from 1990-2001, we identified 200 patients (256 mesiodentes) who were shown to have mesiodentes on the basis of a periapical radiograph, a panoramic radiograph or an axial radiograph.
    Results: The number of supernumerary teeth was one in 146 cases (73%), two in 5 2 cases (26%) and three in 2 cases (1%). Of 256 mesiodentes, the direction of the crown of the mesiodens was inverted in 172 (67%), in a normal direction in 69 (27%) and in a horizontal direction with regard to the tooth axis in 15 (6%). Of the 147 mesiodentes for which axial radiography was performed, 131 (89%) were located at a palatal site against the dental arch, 16 (11%) overlapped the dental arch and none were at a labial site. Of our 200 cases, a delay of eruption of the permanent central incisor was seen in 12 (6%), malposition or rotation of the central incisor in 5 (2.5%) and dentigerous cyst formation arising from mesiodens in 22 (11%). Marked movement of the mesiodens was seen in 10 cases during the follow-up period of 5-7 years. Some complication arising from mesiodens was seen in 19.5% of all cases in our research.
    Conclusion: Although mesiodentes are not caused by malocclusion, they may cause it. A long period of impaction of mesiodentes may bring about dentigerous cyst formation or movement of the mesiodentes.

    DOI: 10.1259/dmfr/68039278

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  • Radiographic examination of mesiodens and their associated complications

    JI Asaumi, Y Shibata, Y Yanagi, M Hisatomi, H Matsuzaki, H Konouchi, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   33 ( 2 )   125 - 127   2004年3月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    Objectives: To examine mesiodens with regard to their status, their influence on adjacent teeth and their alteration during the follow-up period.
    Methods: From retrospective reviews of all patients who visited our institution from 1990-2001, we identified 200 patients (256 mesiodentes) who were shown to have mesiodentes on the basis of a periapical radiograph, a panoramic radiograph or an axial radiograph.
    Results: The number of supernumerary teeth was one in 146 cases (73%), two in 5 2 cases (26%) and three in 2 cases (1%). Of 256 mesiodentes, the direction of the crown of the mesiodens was inverted in 172 (67%), in a normal direction in 69 (27%) and in a horizontal direction with regard to the tooth axis in 15 (6%). Of the 147 mesiodentes for which axial radiography was performed, 131 (89%) were located at a palatal site against the dental arch, 16 (11%) overlapped the dental arch and none were at a labial site. Of our 200 cases, a delay of eruption of the permanent central incisor was seen in 12 (6%), malposition or rotation of the central incisor in 5 (2.5%) and dentigerous cyst formation arising from mesiodens in 22 (11%). Marked movement of the mesiodens was seen in 10 cases during the follow-up period of 5-7 years. Some complication arising from mesiodens was seen in 19.5% of all cases in our research.
    Conclusion: Although mesiodentes are not caused by malocclusion, they may cause it. A long period of impaction of mesiodentes may bring about dentigerous cyst formation or movement of the mesiodentes.

    DOI: 10.1259/dmfr/68039278

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  • Radiographic examination of dentigerous cysts in the transitional dentition

    Y Shibata, J Asaumi, Y Yanagi, N Kawai, M Hisatomi, H Matsuzaki, H Konouchi, H Nagatsuka, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   33 ( 1 )   17 - 20   2004年1月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    Objectives: To examine radiographically the relationship between the deciduous tooth and dentigerous cyst of the permanent successor during the transitional dentition.
    Methods: From a retrospective review of all patients who visited our institution from April 1988 to August 2001, 70 patients under 16 years of age who had histologically confirmed dentigerous cysts that had developed from the central incisor to the second premolar were identified. These 70 patients were investigated using panoramic and periapical radiographs.
    Results: Inmost cases (54 cases; 77.1%) the cyst was in the premolar region. Of the 54 premolars with dentigerous cysts, the overlying deciduous tooth had already been lost in 7 cases. Of the 47 remaining premolars with associated deciduous tooth, 35 (74.5%) had bone resorption of the periapical or bifurcation region, or irregular resorption of the associated deciduous tooth. Of the remaining 12 deciduous teeth with no periapical lesions, 9 had been treated with root canal therapy. Thus, 44 of these 47 cases (93.6%) had the possibility of inflammation at the deciduous tooth associated with the dentigerous cyst. Evidence from one case in the present study suggesting the process by which cyst development occurs is also given.
    Conclusion: Inflammatory change at the apex of the deciduous tooth may bring on a dentigerous cyst of the permanent successor.

    DOI: 10.1259/dmfr/24148363

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  • Radiographic examination of dentigerous cysts in the transitional dentition

    Y Shibata, J Asaumi, Y Yanagi, N Kawai, M Hisatomi, H Matsuzaki, H Konouchi, H Nagatsuka, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   33 ( 1 )   17 - 20   2004年1月

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    記述言語:英語   出版者・発行元:BRITISH INST RADIOLOGY  

    Objectives: To examine radiographically the relationship between the deciduous tooth and dentigerous cyst of the permanent successor during the transitional dentition.
    Methods: From a retrospective review of all patients who visited our institution from April 1988 to August 2001, 70 patients under 16 years of age who had histologically confirmed dentigerous cysts that had developed from the central incisor to the second premolar were identified. These 70 patients were investigated using panoramic and periapical radiographs.
    Results: Inmost cases (54 cases; 77.1%) the cyst was in the premolar region. Of the 54 premolars with dentigerous cysts, the overlying deciduous tooth had already been lost in 7 cases. Of the 47 remaining premolars with associated deciduous tooth, 35 (74.5%) had bone resorption of the periapical or bifurcation region, or irregular resorption of the associated deciduous tooth. Of the remaining 12 deciduous teeth with no periapical lesions, 9 had been treated with root canal therapy. Thus, 44 of these 47 cases (93.6%) had the possibility of inflammation at the deciduous tooth associated with the dentigerous cyst. Evidence from one case in the present study suggesting the process by which cyst development occurs is also given.
    Conclusion: Inflammatory change at the apex of the deciduous tooth may bring on a dentigerous cyst of the permanent successor.

    DOI: 10.1259/dmfr/24148363

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  • Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck.

    Asaumi J, Yanagi Y, Konouchi H, Hisatomi M, Matsuzaki H, Kishi K

    Oral Oncol.   2004年

  • pEYFP-Nuc vector is a useful tool for three-dimensional and time-lapse observation of nuclear morphology of Jurkat cells during apoptosis.

    Int J Mol Med. 2004   13(2): 235-42   2004年

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  • Influence of CpG island methylation status in O6-methylguanine-DNA methyltransferase expression of oral cancer cell lines.

    Oncol Rep.   12(2):339-45.   2004年

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  • Cepharanthin enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines, SaOS2-AR and SaOS2 F-AR.

    Int J Oncol.   25(1):47-56.   2004年

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  • Cepharanthine enhances in vitro and in vivo thermosensitivity of a mouse fibrosarcoma, FSa-II, based on increased apoptosis.

    Int J Mol Med.   13(3):405-11   2004年

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  • pEYFP-Nuc vector is a useful tool for three-dimensional and time-lapse observation of nuclear morphology of Jurkat cells during apoptosis.

    Hasegawa A, Kuroda M, Wang Y, Akaki S, Asaumi J, Shibuya K, Kawasaki S, Okumura Y, Kanazawa S, Hiraki Y

    Int J Mol Med.   2004年

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  • A case of simultaneous occurrence of ameloblastoma and dentigerous cyst.

    Jpn J Oral Diag/Oral Med   17(1): 189-192   2004年

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  • H89, a protein kinase inhibitor, promotes the development of thermotolerance in BHK21 and tsAF8 cells.

    Shibuya K, Kobatake A, Uezu M, Kobayashi T, Matsushita T, Kawasaki S, Hanamoto K, Kato H, Kuroda M, Asaumi J, Hiraki Y

    Jpn J Hyperthermic Oncol   2004年

  • Cepharanthine enhances in vitro and in vivo thermosensitivity of a mouse fibrosarcoma, FSa-II, based on increased apoptosis.

    Wang Y, Kuroda M, Gao XS, Akaki S, Asaumi J, Okumura Y, Shibuya K, Kawasaki S, Joja I, Kato H, Himei K, Dendo S, Kanazawa S, Hiraki Y

    Int J Mol Med   2004年

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  • Cepharanthin enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines, SaOS2-AR and SaOS2 F-AR.

    Katsui K, Kuroda M, Wang Y, Komatsu M, Himei K, Takemoto M, Akaki S, Asaumi J, Kanazawa S, Hiraki Y

    Int J Oncol.   2004年

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  • A case of simultaneous occurrence of ameloblastoma and dentigerous cyst.

    Hisatomi M, Asaumi j, Yanagi y, Konouchi H, Kanji kishi

    Jpn J Oral Diag/Oral Med   2004年

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  • Influence of CpG island methylation status in O6-methylguanine-DNA methyltransferase expression of oral cancer cell lines.

    Murakami J, Asaumi J, Maki Y, Tsujigiwa H, Nagatsuka H, Kokeguchi S, Inoue T, Kawasaki S, Tanaka N, MacPhee D, Matsubara N, Kishi K

    Oncol Rep.   2004年

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  • Treatment of a plunging ranula with fenestration and continuous pressure

    S Takagi, N Mizukawa, T Kimura, JI Asaumi

    BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY   41 ( 6 )   410 - 413   2003年12月

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    記述言語:英語   出版者・発行元:CHURCHILL LIVINGSTONE  

    We present a new method of fenestration and continuous pressure as a simple, effective and uninvasive procedure for the treatment of plunging ranulas. We have recently used in four female patients, aged 10-29 years old. After treatment, the patients remained symptom-free and assessment by magnetic resonance imaging (MRI) showed regression of the ranula in all cases. The procedure resulted in satisfactory healing and we advocate it as a simple and effective treatment that is better for patients than conventional treatment. (C) 2003 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/S0266-4356(03)00083-4

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  • Treatment of a plunging ranula with fenestration and continuous pressure

    S Takagi, N Mizukawa, T Kimura, JI Asaumi

    BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY   41 ( 6 )   410 - 413   2003年12月

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    記述言語:英語   出版者・発行元:CHURCHILL LIVINGSTONE  

    We present a new method of fenestration and continuous pressure as a simple, effective and uninvasive procedure for the treatment of plunging ranulas. We have recently used in four female patients, aged 10-29 years old. After treatment, the patients remained symptom-free and assessment by magnetic resonance imaging (MRI) showed regression of the ranula in all cases. The procedure resulted in satisfactory healing and we advocate it as a simple and effective treatment that is better for patients than conventional treatment. (C) 2003 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/S0266-4356(03)00083-4

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  • Assessment of pleomorphic adenomas using MRI and dynamic contrast enhanced MRI

    M Hisatomi, J Asaumi, Y Yanagi, H Konouchi, H Matsuzaki, Y Honda, K Kishi

    ORAL ONCOLOGY   39 ( 6 )   574 - 579   2003年9月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We evaluated magnetic resonance images (MRI) and the value of dynamic contrast enhanced MRI (DCE-MRI) of pleomorphic adenomas retrospectively. MRI was performed for 18 pleomorphic adenomas, including 11 cases with DCE-MRI. We obtained the following results on the MRI and DCE-MRI. (a) Pleomorphic adenomas showed a predilection for homogeneous intermediate signal intensity on T1-weighted images (T1WI), heterogeneous high signal intensity on T2-weighted images, and heterogeneous enhancement on Gd-T1WI. (b) Of 11 contrast index (CI) curves of pleomorphic adenomas, nine CI curves (81.8%) increased gradually to 600 s or increased gradually, reached a plateau, and sustained the plateau to 600 s. The remaining two (18.2%) increased gradually and decreased gradually thereafter. (c) CI curves reached the maximum CI index at 135-300 s. (C) 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S1368-8375(03)00040-X

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  • Assessment of pleomorphic adenomas using MRI and dynamic contrast enhanced MRI

    M Hisatomi, J Asaumi, Y Yanagi, H Konouchi, H Matsuzaki, Y Honda, K Kishi

    ORAL ONCOLOGY   39 ( 6 )   574 - 579   2003年9月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We evaluated magnetic resonance images (MRI) and the value of dynamic contrast enhanced MRI (DCE-MRI) of pleomorphic adenomas retrospectively. MRI was performed for 18 pleomorphic adenomas, including 11 cases with DCE-MRI. We obtained the following results on the MRI and DCE-MRI. (a) Pleomorphic adenomas showed a predilection for homogeneous intermediate signal intensity on T1-weighted images (T1WI), heterogeneous high signal intensity on T2-weighted images, and heterogeneous enhancement on Gd-T1WI. (b) Of 11 contrast index (CI) curves of pleomorphic adenomas, nine CI curves (81.8%) increased gradually to 600 s or increased gradually, reached a plateau, and sustained the plateau to 600 s. The remaining two (18.2%) increased gradually and decreased gradually thereafter. (c) CI curves reached the maximum CI index at 135-300 s. (C) 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S1368-8375(03)00040-X

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  • Incidentally found and unexpected tumors discovered by MRI examination for temporomandibular joint arthrosis

    Y Yanagi, J Asaumi, Y Maki, J Murakami, M Hisatomi, H Matsuzaki, H Konouchi, Y Honda, K Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   47 ( 1 )   6 - 9   2003年7月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

    DOI: 10.1016/S0720-048X(03)00095-0

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  • Incidentally found and unexpected tumors discovered by MRI examination for temporomandibular joint arthrosis

    Y Yanagi, J Asaumi, Y Maki, J Murakami, M Hisatomi, H Matsuzaki, H Konouchi, Y Honda, K Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   47 ( 1 )   6 - 9   2003年7月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

    DOI: 10.1016/S0720-048X(03)00095-0

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  • Quiz case

    Eur J Radiol Extra   47(2):52-54   2003年

  • Effects of p53 gene therapy in radiotherapy or thermotherapy of human head and neck squamous cell carcinoma cell lines.

    Oncol Rep   10(3), 671-7   2003年

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  • Thermoradiotherapy combined with adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines.

    Oncol Rep   10(2), 415-20   2003年

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  • Thermoradiotherapy combined with p53 gene therapy of human salivary gland adenocarcinoma cell line.

    Oncology Reports   10(1):71-74   2003年

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  • MR imaging in the assessment of a solitary bone cyst

    Hidenobu Matsuzaki, Jun-Ichi Asaumi, Yoshinobu Yanagi, Hironobu Konouchi, Yasutoshi Honda, Miki Hisatomi, Hiroshi Shigehara, Kanji Kishi

    European Journal of Radiology Extra   45 ( 1 )   37 - 42   2003年

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    記述言語:英語   出版者・発行元:Elsevier BV  

    Introduction: It might be difficult to differentiate solitary bone cysts (SBCs) from other cysts and tumors when the lesion occurs at an unusual location and/or shows atypical radiographic features. Magnetic resonance imaging (MRI) is the most useful modality for evaluating the internal structure of lesions and may have the ability to distinguish SBCs from other lesions. However, few studies exist regarding MRI of SBCs in the oral region. The present study reports on the MR imaging of nine patients with SBCs and describes the diagnostic value of the MRI findings. Materials and methods: Nine patients with SBCs in the mandible were examined using MRI. In all patients, T1- and T2-weighted images (T1-WI, T2-WI) were obtained and contrast enhanced images and dynamic MRI were performed in four cases. Results: MR findings revealed homogeneous intermediate signal intensities (SI) on T1-WI and high SI on T2-WI in all cases. These SI indicated that the SBCs included homogeneous liquid. On the dynamic MRIs in all cases, the SBCs were enhanced from the margin to the inner part, indicating a gradual exudation of the contrast agent from the surrounding medullae to the inner part. These phenomena were not observed on the dynamic MRIs of the other true cysts with epithelial lining. Conclusion: MRI, especially dynamic MRI, can provide useful information for distinguishing SBCs from other cysts or tumors. Furthermore, dynamic MRI findings suggested that the liquid components of SBCs might have infiltrated from the surrounding medullae. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

    DOI: 10.1016/S1571-4675(03)00021-X

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  • Biofilm Formation by a Fimbriae-Deficient Mutant of Actinobacillus actinomycetemcomitans

    Microbiol. Immunol.   47(11):877-881   2003年

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  • MR imaging in the assessment of a solitary bone cyst

    Hidenobu Matsuzaki, Jun-Ichi Asaumi, Yoshinobu Yanagi, Hironobu Konouchi, Yasutoshi Honda, Miki Hisatomi, Hiroshi Shigehara, Kanji Kishi

    European Journal of Radiology Extra   45 ( 1 )   37 - 42   2003年

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    記述言語:英語   出版者・発行元:Elsevier BV  

    Introduction: It might be difficult to differentiate solitary bone cysts (SBCs) from other cysts and tumors when the lesion occurs at an unusual location and/or shows atypical radiographic features. Magnetic resonance imaging (MRI) is the most useful modality for evaluating the internal structure of lesions and may have the ability to distinguish SBCs from other lesions. However, few studies exist regarding MRI of SBCs in the oral region. The present study reports on the MR imaging of nine patients with SBCs and describes the diagnostic value of the MRI findings. Materials and methods: Nine patients with SBCs in the mandible were examined using MRI. In all patients, T1- and T2-weighted images (T1-WI, T2-WI) were obtained and contrast enhanced images and dynamic MRI were performed in four cases. Results: MR findings revealed homogeneous intermediate signal intensities (SI) on T1-WI and high SI on T2-WI in all cases. These SI indicated that the SBCs included homogeneous liquid. On the dynamic MRIs in all cases, the SBCs were enhanced from the margin to the inner part, indicating a gradual exudation of the contrast agent from the surrounding medullae to the inner part. These phenomena were not observed on the dynamic MRIs of the other true cysts with epithelial lining. Conclusion: MRI, especially dynamic MRI, can provide useful information for distinguishing SBCs from other cysts or tumors. Furthermore, dynamic MRI findings suggested that the liquid components of SBCs might have infiltrated from the surrounding medullae. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

    DOI: 10.1016/S1571-4675(03)00021-X

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  • The effect of various chemotherapeutic agents given with mild hyperthermia on different types of tumours

    M Takemoto, M Kuroda, M Urano, Y Nishimura, S Kawasaki, H Kato, Y Okumura, S Akaki, S Kanazawa, J Asaumi, Joja, I, Y Hiraki

    INTERNATIONAL JOURNAL OF HYPERTHERMIA   19 ( 2 )   193 - 203   2003年

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS LTD  

    It has been shown that hyperthermia can enhance the cytotoxicity of some chemotherapeutics. However, the most effective agent(s) at elevated temperatures have yet to be determined. A previous study suggests that the drug of choice at elevated temperatures may be different from that at the physiological temperature, and that the alkylating agents may be most effective at elevated temperatures. To further investigate these possibilities, the effect of chemotherapeutic agents were compared. These agents were cyclophosphamide, ifosfamide, melphalan, cis-diamminedichloroplatinum (II), 5-fluorouracil, mitomycin C and bleomycin. Three tumours ( mammary carcinoma, osteosarcoma and squamous cell carcinoma) were used. They were transplanted into the feet of C3H/He mice. When tumours reached 65 mm(3) a test agent was injected intraperitoneally. Tumours were immediately heated at 41.5degreesC for 30 min, and the tumour growth (TG) time was studied for each tumour. Using the TG times, the TG-50 (the time required for one-half of the total number of the treated tumours to reach the volume of 800 mm(3) from 65 mm(3)) was calculated. Subsequently, the tumour growth delay time (GDT) and the thermal enhancement ratio (TER) were obtained. The GDT was the difference between the TG-50 of treated tumours and that of non-treated control tumours. The TER was the ratio of the GDT of a group treated with an agent at 41.5degreesC to that of a group treated with the agent at room temperature. Results showed that the top three effective agents tested at 41.5degreesC were solely alkylating agents-CY, IFO and L-PAM-for each kind of tumour. A GDT of cisplatin was smaller than those of the alkylating agents. The smallest TER, 1.1, was observed for 5-fluorouracil, which was given for mammary carcinoma, and for mitomycin C, which was given for squamous cell carcinoma. It could be concluded that the alkylating agents at elevated temperatures might be the drugs of choice for many types of tumours. The possible mechanisms of thermal enhancement associated with these agents are discussed.

    DOI: 10.1080/0265673021000035235

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  • MR features of aneurysmal bone cyst of the mandible and characteristics distinguishing it from other lesions.

    Asaumi J, Konouchi H, Hisatomi M, Matsuzaki H, Shigehara H, Honda Y, Kishi K

    Eur J Radiol   2003年

  • MR features of aneurysmal bone cyst of the mandible and characteristics distinguishing it from other lesions

    Eur J Radiol   45(2), 108-12   2003年

  • Thermoradiotherapy combined with p53 gene therapy of human salivary gland adenocarcinoma cell line.

    Asaumi J, Higuchi Y, Murakami J, Matsuzaki H, Wakasa T, Inoue T, Shigehara H, Konouchi H, Hisatomi M, Kawasaki S, Kuroda M, Hiraki Y, Kishi K

    Oncol Rep   2003年

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  • Evaluation of tumor proliferation using dynamic contrast enhanced-MRI of oral cavity and oropharyngeal squamous cell carcinoma.

    Konouchi H, Asaumi J, Yanagi Y, Shigehara H, Hisatomi M, Matsuzaki H, Kishi K

    Oral Oncology   2003年

  • Evaluation of tumor proliferation using dynamic contrast enhanced-MRI of oral cavity and oropharyngeal squamous cell carcinoma

    Oral Oncology   39(3), 290-295   2003年

  • Thermoradiotherapy combined with adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines.

    Higuchi Y, Asaumi J, Murakami J, Wakasa T, Inoue T, Matsuzaki H, Konouchi H, Hisatomi M, Yanagi Y, Honda Y, Shigehara H, Kishi K

    Oncol Rep   2003年

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  • The effect of various chemotherapeutic agents given with mild hyperthermia on different types of tumours

    M Takemoto, M Kuroda, M Urano, Y Nishimura, S Kawasaki, H Kato, Y Okumura, S Akaki, S Kanazawa, J Asaumi, Joja, I, Y Hiraki

    INTERNATIONAL JOURNAL OF HYPERTHERMIA   19 ( 2 )   193 - 203   2003年

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS LTD  

    It has been shown that hyperthermia can enhance the cytotoxicity of some chemotherapeutics. However, the most effective agent(s) at elevated temperatures have yet to be determined. A previous study suggests that the drug of choice at elevated temperatures may be different from that at the physiological temperature, and that the alkylating agents may be most effective at elevated temperatures. To further investigate these possibilities, the effect of chemotherapeutic agents were compared. These agents were cyclophosphamide, ifosfamide, melphalan, cis-diamminedichloroplatinum (II), 5-fluorouracil, mitomycin C and bleomycin. Three tumours ( mammary carcinoma, osteosarcoma and squamous cell carcinoma) were used. They were transplanted into the feet of C3H/He mice. When tumours reached 65 mm(3) a test agent was injected intraperitoneally. Tumours were immediately heated at 41.5degreesC for 30 min, and the tumour growth (TG) time was studied for each tumour. Using the TG times, the TG-50 (the time required for one-half of the total number of the treated tumours to reach the volume of 800 mm(3) from 65 mm(3)) was calculated. Subsequently, the tumour growth delay time (GDT) and the thermal enhancement ratio (TER) were obtained. The GDT was the difference between the TG-50 of treated tumours and that of non-treated control tumours. The TER was the ratio of the GDT of a group treated with an agent at 41.5degreesC to that of a group treated with the agent at room temperature. Results showed that the top three effective agents tested at 41.5degreesC were solely alkylating agents-CY, IFO and L-PAM-for each kind of tumour. A GDT of cisplatin was smaller than those of the alkylating agents. The smallest TER, 1.1, was observed for 5-fluorouracil, which was given for mammary carcinoma, and for mitomycin C, which was given for squamous cell carcinoma. It could be concluded that the alkylating agents at elevated temperatures might be the drugs of choice for many types of tumours. The possible mechanisms of thermal enhancement associated with these agents are discussed.

    DOI: 10.1080/0265673021000035235

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  • Comparison of radiographic and MRI features of a root-diverging odontogenic myxoma, with discussion of the differential diagnosis of lesions likely to move roots

    Oral Diseases   9(3):152-157   2003年

  • H89, a protein kinase inhibitor, promotes the development of thermotolerance in BHK21 and tsAF8 cells.

    Jpn J Hyperthermic Oncol   19(4):187-193   2003年

  • Effects of p53 gene therapy in radiotherapy or thermotherapy of human head and neck squamous cell carcinoma cell lines.

    Higuchi Y, Asaumi J, Murakami J, Matsuzaki H, Wakasa T, Inoue T, Shigehara H, Konouchi H, Hisatomi M, Kawasaki S, Hiraki Y, Kishi K

    Oncol Rep   2003年

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  • Comparison of radiographic and MRI features of a root-diverging odontogenic myxoma, with discussion of the differential diagnosis of lesions likely to move roots.

    Hisatomi M, Asaumi J, Konouchi H, Yanagi Y, Matsuzaki H, Kishi K

    Oral Diseases   2003年

  • The value of dynamic contrast-enhanced MRI in diagnosis of malignant lymphoma of the head and neck

    European Journal of Radiology   48(2): 183-187   2003年

  • Usefulness of dynamic contrast-enhanced MRI in the differential diagnosis of angioleiomyoma in the buccal space

    Yoshinobu Yanagi, Jun-Ichi Asaumi, Miki Hisatomi, Hidenobu Matsuzaki, Yosutoshi Honda, Hironobu Konouchi, Kanji Kishi

    European Journal of Radiology Extra   48 ( 1 )   14 - 18   2003年

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    記述言語:英語   出版者・発行元:Elsevier BV  

    We describe a case of angioleiomyoma in the buccal space, and discuss its magnetic resonance imaging (MRI) features with histopathological correlation, with particular emphasis on the usefulness of using dynamic contrast-enhanced MRI (DCE-MRI) to differentiate other possible tumors. Angioleiomyoma of the buccal space in this case corresponded clinically and histopathologically to the previous reports. The characteristic findings of angioleiomyoma were a very high signal intensity on T2WI, and extremely high enhancement on Gd-T1WI. The inner aspect of this lesion was homogeneous on both T1WI and T2WI. However, the histopathological findings included tumor substance, mucous degeneration, and mature adipose cells, and these findings were reflected only on the DCE-MRI. Furthermore, the CI-Curve of the angioleiomyoma showed a characteristic pattern, which might differentiate it from other tumors. © 2003 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/S1571-4675(03)00080-4

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  • Usefulness of dynamic contrast-enhanced MRI in the differential diagnosis of angioleiomyoma in the buccal space

    Yoshinobu Yanagi, Jun-Ichi Asaumi, Miki Hisatomi, Hidenobu Matsuzaki, Yosutoshi Honda, Hironobu Konouchi, Kanji Kishi

    European Journal of Radiology Extra   48 ( 1 )   14 - 18   2003年

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    記述言語:英語   出版者・発行元:Elsevier BV  

    We describe a case of angioleiomyoma in the buccal space, and discuss its magnetic resonance imaging (MRI) features with histopathological correlation, with particular emphasis on the usefulness of using dynamic contrast-enhanced MRI (DCE-MRI) to differentiate other possible tumors. Angioleiomyoma of the buccal space in this case corresponded clinically and histopathologically to the previous reports. The characteristic findings of angioleiomyoma were a very high signal intensity on T2WI, and extremely high enhancement on Gd-T1WI. The inner aspect of this lesion was homogeneous on both T1WI and T2WI. However, the histopathological findings included tumor substance, mucous degeneration, and mature adipose cells, and these findings were reflected only on the DCE-MRI. Furthermore, the CI-Curve of the angioleiomyoma showed a characteristic pattern, which might differentiate it from other tumors. © 2003 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/S1571-4675(03)00080-4

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  • Quiz case. Radiological and magnetic resonance appearance of maxillary disease.

    Hisatomi M, Asaumi J, Konouchi H, Kishi K

    European Journal of Radiology Extra   2003年

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  • Biofilm formation by a fimbriae-deficient mutant of Actinobacillus actinomycetemcomitans.

    Inoue T, Shingaki R, Sogawa N, Sogawa CA, Asaumi J, Kokeguchi S, Fukui K

    Microbiol Immunol   2003年

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  • MR imaging of epithelial cysts of the oral and maxillofacial region.

    Hisatomi M, Asaumi J, Konouchi H, Shigehara H, Yanagi Y, Kishi K

    Eur J Radiol   2003年

  • MR imaging of epithelial cysts of the oral and maxillofacial region

    European Journal of Radiology   48( 2 ): 178-182   2003年

  • The value of dynamic contrast-enhanced MRI in diagnosis of malignant lymphoma of the head and neck.

    Asaumi J, Yanagi Y, Hisatomi M, Matsuzaki H, Konouchi H, Kishi K

    Eur J Radiol   2003年

  • Protein kinaseの阻害剤であるH89はBHK21細胞とtsAF8細胞の温熱耐性の発現を促進する(H89, a Protein Kinase Inhibitor, Promotes the Development of Thermotolerance in BHK21 and tsAF8 Cells)(英語)

    澁谷光一, 小畑文香, 上江洲美緒, 小林貴子, 松下利, 川崎祥二, 花元克巳, 加藤博和, 黒田昌宏, 浅海淳一, 平木祥夫

    日本ハイパーサーミア学会誌   2003年

  • Late course accelerated hyperfractionation radiotherapy concomitant with cisplatin in patients with esophageal carcinoma.

    Oncol Rep   9(4): 767-72   2002年

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  • Cell cycle of tsAF8 after heating

    Bull Fac Health Sci. Okayama Univ Med Sch   12(2):101-106   2002年

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  • Thermochemotherapy of a human salivary adenocarcinoma cell line

    Oncol Rep   9 ( 2:365-369 )   2002年

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  • Effect of wortmannin on the suppression of thermotolerance in tsAF8 cells

    Oncol Rep   9 ( 1:81-84 )   2002年

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  • Adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines.

    Oncol Rep   9(6):1233-1236   2002年

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  • Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines.

    Int J Mol Med   10 ( 3:287-291 )   2002年

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  • Aneurysmal bone cyst of the mandible

    Jpn J Oral Diag Oral med   15(2): 352-358   2002年

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  • Assessment of carcinoma in the sublingual region based on magnetic resonance imaging.

    Oncol Rep   9(6):1283-1287   2002年

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  • A case of complex odontoma associated with an impacted lower deciduous second molar and analysis of the 107 odontomas

    Oral Dis   8 ( 2:100-105 )   2002年

  • Thermochemotherapy of a human salivary adenocarcinoma cell line.

    Asaumi J, Higuchi Y, Matsuzaki H, Murakami J, Kawasaki S, Kuroda M, Shibuya K, Konouchi H, Hisatomi M, Wakasa T, Kishi K, Hiraki Y

    Oncology Reports   2002年

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  • Thermochemotherapy of a human salivary adenocarcinoma cell line.

    Asaumi J, Higuchi Y, Matsuzaki H, Murakami J, Kawasaki S, Kuroda M, Shibuya K, Konouchi H, Hisatomi M, Wakasa T, Kishi K, Hiraki Y

    Oncol Rep   2002年

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  • Effect of wortmannin on the suppression of thermotolerance in tsAF8 cells.

    Shibuya K, Kawasaki S, Kuroda M, Takemoto M, Asaumi JI, Hiraki Y

    Oncology Reports   2002年

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  • Assessment of dynamic MRI of Warthin's tumors arising as multiple lesions in the parotid glands

    Miki Hisatomi, Jun-ichi Asaumi, Hironobu Konouchi, Yoshinobu Yanagi, Hidenobu Matsuzaki, Kanji Kishi

    Oral Oncology   2002年

  • Assessment of dynamic MRI of Warthin's tumors arising as multiple lesions in the parotid glands

    Oral Oncol   38 (4):369-372   2002年

  • A case of complex odontoma associated with an impacted lower deciduous second molar and analysis of the 107 odontomas.

    Hisatomi M, Asaumi JI, Konouchi H, Honda Y, Wakasa T, Kishi K

    Oral Diseases   2002年

  • A case of complex odontoma associated with an impacted lower deciduous second molar and analysis of the 107 odontomas.

    Hisatomi M, Asaumi JI, Konouchi H, Honda Y, Wakasa T, Kishi K

    Oral Dis   2002年

  • Late course accelerated hyperfractionation radiotherapy concomitant with cisplatin in patients with esophageal carcinoma.

    Gao XS, Qiao XY, Yang XR, Asaumi J, Zhou ZG, Wang YD, Zhou DA, Wan J, Kuroda M, Kishi K, Kawasaki S, Hiraki Y

    Oncogyl Reports   2002年

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  • Application of dynamic MRI to differentiating odontogenic myxomas from ameloblastomas.

    Asaumi J, Matsuzaki H, Hisatomi M, Konouchi H, Shigehara H, Kishi K

    European Journal of Radiology   2002年

  • Application of dynamic MRI to differentiating odontogenic myxomas from ameloblastomas.

    Eur J Radiol   43 (1):37-41   2002年

  • Adenomatoid odontogenic tumor: correlation of MRI with histopathological findings.

    Eur J Radiol   44(1):19-23   2002年

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  • Mandibular metastasis presenting as the initial maifestation of malignant pheochromocytoma.

    Yanagi Y, Asaumi J, Hisatomi M, Konouchi H, Wakasa T, Kishi K

    European Journal of Radiology   2002年

  • Mandibular metastasis presenting as the initial maifestation of malignant pheochromocytoma.

    Eur J Radiol   44(1):5-9   2002年

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  • Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines.

    Asaumi J, Higuchi Y, Murakami J, Kuroda M, Shibuya K, Konouchi H, Hisatomi M, Matsuzaki H, Shigehara H, Kawasaki S, Kishi K, Hiraki Y

    International Journal of Molecular and Medicine   2002年

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  • Assessment of carcinoma in the sublingual region based on magnetic resonance imaging.

    Asaumi J, Shigehara H, Konouchi H, Yanagi Y, Hisatomi M, Matsuzaki H, Kishi K

    Oncology Reports   2002年

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  • Adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines.

    Higuchi Y, Asaumi J, Murakami J, Wakasa T, Inoue T, Kuroda M, Shibuya K, Shigehara H, Kawasaki S, Fukui K, Kishi K, Hiraki Y

    Oncology Reports   2002年

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  • Adenomatoid odontogenic tumor: correlation of MRI with histopathological findings.

    Konouchi H, Asaumi J, Yanagi Y, Hisatomi M, Kishi K

    European Journal of Radiology   2002年

  • 両側耳下腺にみられた多発性Warthin腫瘍の1例ー術前診断に対するダイナミックMRIの有用性についてー

    岸本晃治, 小野達生, 上山吉哉, 新谷 悟, 佐々木 朗, 松村智弘, 浅海淳一, 岸 幹二

    岡山歯学   2002年

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  • 直接法歯科用デジタルX線撮影による顎骨内病変の検出能に関する検討

    若狭 亨, 河井紀子, 浅海淳一, 秋田和俊, 守屋市朗, 中津継夫, 岸 幹二

    岡山歯学   2002年

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  • Aneurysmal bone cyst of the mandible

    Wakasa T, Asaumi J, Honda Y, Konouchi H, Kishi K

    Jpanese Journal of Oral Diag Oral medicine   2002年

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  • Cell cycle of tsAF8 after heating.

    Shibuya K, Kawasaki S, Kuroda M, Asaumi J, Kato H, Hiraki Y

    Bull Fac Health Sci. Okayama Univ Med Sch   2002年

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  • Effects of PKC inhibitors on suppression of thermotolerance development in tsAF8 cells

    K Shibuya, S Kawasaki, M Kuroda, J Asaumi, S Kanazawa, Y Hiraki

    INTERNATIONAL JOURNAL OF HYPERTHERMIA   17 ( 2 )   106 - 113   2001年3月

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS LTD  

    Effects of protein kinase C (PKC) inhibitors (H7, staurosporine, calphostin C) on thermotolerance development were investigated in temperature sensitive tsAF8 cells derived from Syrian hamster BHK21 cells. Cells were pre-heated at 45 degreesC for 20 min, incubated at 34 degreesC with PKC inhibitors for varying lengths of time, i.e. 1.25-10.0 h, and then heated at 45 degreesC for 30 min. Increasing survival fractions after the second heat treatment was inhibited by the treatment with H7 (40-160 muM), with staurosporine (0.05-1.0 muM), and with calphostin C (0.8, 1.2 muM) in a concentration dependent manner. When the concentrations of these PKC inhibitors were low, the restraint of increasing survival fractions was temporary, since survival fractions increased 3-7.5 h after pre-heating. However, the survival fractions were almost constant by the treatment with 160 muM H7 and 1.0 muM staurosporine. Induction of HSP72 after heat stress was investigated in tsAF8 and BHK21 cells. Cells were heated at 45 degreesC for 20 min and incubated at 34 or 39.7 degreesC (tsAF8), at 37 degreesC (BHK21). Intensity of intracellular fluorescence from HSP72 was measured by flow cytometry. HSP72 was induced in BHK21 cells, but there was no definite induction of HSP72 in tsAF8 cells at either 39.7 or 34 degreesC. These results suggest that PKC is related with the thermotolerance development in tsAF8 cells; however, HSP72 is not involved in the thermotolerance development in tsAF8 cells.

    DOI: 10.1080/02656730010010667

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  • Odontogenic myxoma of maxillary sinus: CT and MR-pathologic correlation

    J Asaumi, H Konouchi, M Hisatomi, K Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   37 ( 1 )   1 - 4   2001年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    We showed the characteristic features of odontogenic myxoma in the maxillary sinus with computed tomography (CT), magnetic resonance imaging (MRI), and histopathological findings. CT images showed a multilocular soft tissue mass with bone destruction and thinning, and the characteristic finding of this lesion as strands of fine lacelike density. MRI revealed intermediate signal intensity on T1-weighted image and high signal intensity on T2-weighted image. MRI showed the erosive extent of the lesion into the adjacent structures. In contrast T1-weighted image, the peripheral portion of the lesion with a relatively large quantity of collagen bundles was enhanced, while the central portion with only mucoid component was not. The CT and MRI appearances correlated well with the histologic features and therefore were considered to be a useful tool for diagnosis of myxoma. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

    DOI: 10.1016/S0720-048X(00)00229-1

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  • Odontogenic myxoma of maxillary sinus:CT and MR-pathologic correlation

    Asaumi J, Konouchi H, Hisatomi M, Matsuzaki H, Kishi K

    Eur J Radiol   2001年

  • MR imaging of nasopalatine duct cysts.

    Eur J Radiol   39(2):73-76   2001年

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  • Application of a new fluorescent microscopic system for research in radiation biology

    Masahiro Kuroda, Wang Yadi, Komatsu Megumi, Asaumi Junichi, Koh-Ichi Shibuya, Shoji Kawasaki, Yoshihiro Okumura, Shiro Akaki, Susumu Kanazawa, Osamu Honda, Yoshio Hlrakl

    Journal of JASTRO   13 ( 2 )   119 - 124   2001年

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    記述言語:英語  

    We developed and herein introduce a new microscopic system for automatic acquisition of time-lapse images of both brightfield images and four kinds of fluorescence images. We combined an inverted incident-light fluorescence microscope with an incubation system, a Hoffman Modulation Contrast device, a color chilled 3CCD camera, and an automatic excitation-filter exchanger. The light source switching for brightfield imaging was controlled automatically by a computer. Cells were maintained in 5% CO2 plus 95% air at 37° C on a microscopic stage with an incubation system, which consists of a gas-regulatory system and two separate temperature-control devices. The fluorescence of annexin V (AV)-enhanced green fluorescent protein (EGFP), AV-fluorescein isothiocyanate, and propidium iodide (PI) diminished 3%, 77%, and 28%, respectively, at 24 hours during time-lapse observation using this system. Time-lapse observation of individual Jurkat cells using this system confirmed that anti-Fas antibody-mediated apoptotic cells occurred at first budding and were stained with AV-EGFP alone, and thereafter were also stained with PI when the cells became flat as a result of ruptures of the plasma membrane. These results present direct evidence that apoptotic cells undergo secondary necrosis, which could be recognized based on PI staining. There was a significantly long time interval between the staining of individual cells with AV-EGFP, indicating apoptosis, and the staining of these cells with PI, which indicated the occurrence of secondary necrosis. On the other hand, most of the cells that underwent necrosis were detected simultaneously with AV-EGFP and PI. The microscopic system we developed allows time-lapse and simultaneous observation of individual cells for changes in both morphology and staining pattern of fluorescent dyes that allow the visualization of cellular function. This system might be a useful tool for research in radiation biology. © 2001, Japanese Society for Therapeutic Radiology and Oncology. All rights reserved.

    DOI: 10.11182/jastro1989.13.119

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  • Application of a new fluorescent microscopic system for research in radiation biology

    Masahiro Kuroda, Wang Yadi, Komatsu Megumi, Asaumi Junichi, Koh-Ichi Shibuya, Shoji Kawasaki, Yoshihiro Okumura, Shiro Akaki, Susumu Kanazawa, Osamu Honda, Yoshio Hlrakl

    Journal of JASTRO   13 ( 2 )   119 - 124   2001年

     詳細を見る

    記述言語:英語  

    We developed and herein introduce a new microscopic system for automatic acquisition of time-lapse images of both brightfield images and four kinds of fluorescence images. We combined an inverted incident-light fluorescence microscope with an incubation system, a Hoffman Modulation Contrast device, a color chilled 3CCD camera, and an automatic excitation-filter exchanger. The light source switching for brightfield imaging was controlled automatically by a computer. Cells were maintained in 5% CO2 plus 95% air at 37° C on a microscopic stage with an incubation system, which consists of a gas-regulatory system and two separate temperature-control devices. The fluorescence of annexin V (AV)-enhanced green fluorescent protein (EGFP), AV-fluorescein isothiocyanate, and propidium iodide (PI) diminished 3%, 77%, and 28%, respectively, at 24 hours during time-lapse observation using this system. Time-lapse observation of individual Jurkat cells using this system confirmed that anti-Fas antibody-mediated apoptotic cells occurred at first budding and were stained with AV-EGFP alone, and thereafter were also stained with PI when the cells became flat as a result of ruptures of the plasma membrane. These results present direct evidence that apoptotic cells undergo secondary necrosis, which could be recognized based on PI staining. There was a significantly long time interval between the staining of individual cells with AV-EGFP, indicating apoptosis, and the staining of these cells with PI, which indicated the occurrence of secondary necrosis. On the other hand, most of the cells that underwent necrosis were detected simultaneously with AV-EGFP and PI. The microscopic system we developed allows time-lapse and simultaneous observation of individual cells for changes in both morphology and staining pattern of fluorescent dyes that allow the visualization of cellular function. This system might be a useful tool for research in radiation biology. © 2001, Japanese Society for Therapeutic Radiology and Oncology. All rights reserved.

    DOI: 10.11182/jastro1989.13.119

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  • The effect of calcium on Fas-mediated apoptosis and secondary necrosis of Jurkat cells.

    Ando Y, Kuroda M, Honda O, Asaumi J, Okumura Y, Takeda Y, Akaki S, Kanazawa S, Kawasaki S, Hiraki Y

    Int J Mol Med   2001年

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  • CT and MR imaging of localized amyloidosis.

    Asaumi J, Yanagi Y, Hisatomi M, Konouchi H, Kishi K

    Eur J Radiol   2001年

  • CT and MR imaging of localized amyloidosis

    J. Asaumi, Y. Yanagi, M. Hisatomi, H. Konouchi, K. Kishi

    European Journal of Radiology   39 ( 2 )   83 - 87   2001年

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    記述言語:英語  

    The localized form of amyloidosis affecting the head and neck region is rare. The characteristic features of localized amyloidosis appeared as multiple nodules on the tongue, lip, and cheek on computed tomography (CT) and magnetic resonance imaging (MRI). Contrast-enhanced CT scans represented this lesion as a marked nodular enhancement. MR features of this lesion appeared slightly low on T1-weighted images and slightly high on T2-weighted images compared with T1-T2 images of residual normal tongue. Time contrast intensity curves obtained from dynamic MRI rapidly increased to reach a plateau and gradually decreased during the late and delayed phases. MR findings suggest that such lesions might be comprised of fibrous tissue with abundant vessels. This report suggests that dynamic MRI might be helpful for diagnosing localized amyloidosis. Copyright © 2001 Elsevier Science Ireland Ltd.

    DOI: 10.1016/S0720-048X(01)00300-X

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  • MR imaging of nasopalatine duct cysts.

    Hisatomi M, Asaumi J, Konouchi H, Matsuzaki H, Kishi K

    Eur J Radiol   2001年

  • Effects of PKC inhibitors on suppression of thermotolerance development in tsAF8 cells.

    Shibuya K, Kawasaki S, Kuroda M, Asaumi J, Kanazawa S, Hiraki Y

    Int J Hyperthermia   2001年

  • Comparison of three-dimensional computed tomography with rapid prototype models in the management of coronoid hyperplasia.

    Asaumi J, Kawai N, Honda Y, Shigehara H, Wakasa T, Kishi K

    Dentomaxillofac Radiol   2001年

  • Comparison of three-dimensional computed tomography with rapid prototype models in the management of coronoid hyperplasia

    Dentomaxillofacial Radiology   30(6):330-335   2001年

  • Effect of wortmannin on the suppression of thermotolerance in tsAF8 cells.

    Shibuya K, Kawasaki S, Kuroda M, Takemoto M, Asaumi JI, Hiraki Y

    Oncol Rep   2001年

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  • Advanced imaging of renal osteodystrophy in the oral and maxillofacial region

    Asaumi J, Aiga H, Hisatomi M, Shigehara H, Kishi K

    Dentomaxillofac Radiol   2001年

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  • Advanced imaging of renal osteodystrophy in the oral and maxillofacial region

    Dentomaxillofac Radiol   30 ( 1 )   59 - 62   2001年

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  • The effect of calcium on Fas-mediated apoptosis and secondary necrosis of Jurkat cells.

    Int J Mol Med   7 ( 3 )   243 - 247   2001年

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  • Two cases of polyostotic eosinophilic granuloma

    J Asaumi, H Konouchi, M Hisatomi, H Matsuzaki, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   29 ( 6 )   382 - 385   2000年11月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    We report two cases of polyostotic eosinophilic granuloma (EG). Both plain radiographs and CT showed diffuse osteolytic lesions which suggested malignant tumors. Although EG was polyostotic, the prognosis was relatively good. Both cases developed new lesions over a followup period of 4-5 years and therefore further long-term review is needed.

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  • Schwannoma of the upper lip: Ultrasound, CT, and MRI findings

    J Asaumi, H Konouchi, K Kishi

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   58 ( 10 )   1173 - 1175   2000年10月

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    記述言語:英語   出版者・発行元:W B SAUNDERS CO  

    DOI: 10.1053/joms.2000.9584

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  • Inhibition of thermotolerance observed on tsAF8 cells

    K Shibuya, S Kawasaki, M Kuroda, J Asaumi, Y Hiraki

    INTERNATIONAL JOURNAL OF HYPERTHERMIA   16 ( 5 )   449 - 456   2000年9月

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS LTD  

    The characteristic development of thermotolerance was examined in tsAF8 cells, which were temperature sensitive cell line derived from BHK21. tsAF8 cells lose RNA polymerase II activity and arrest in the G(1) phase of the cell cycle at the nonpermissive temperature of 39.5-40.6 degrees C. tsAF8 cells were pre-heated at 45 degrees C f or 20 min, incubated at 34 or 39.7 degrees C for different durations, and then heated again at 45 degrees C for 30 min. The cells were trypsinized immediately after the second heating to evaluate cell survival. As a result, thermotolerance was developed rapidly in the cells incubated at 34 degrees C. However, the survival rate of the cells incubated at 39.7 degrees C was almost constant. Thermotolerance of BHK21 cells, which were wild-type cells of tsAF8 cells, developed at 39.7 degrees C. These results suggest that thermotolerance may be inhibited in tsAF8 cells incubated at 39.7 degrees C, and that some metabolism which is inhibited in tsAF8 cells at 39.7 degrees C may be related to thermotolerance development.

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  • Effects of quercetin on the cell growth and the intracellular accumulation and retention of adriamycin

    JI Asaumi, H Matsuzaki, S Kawasak, M Kuroda, Y Takeda, K Kishi, Y Hiraki

    ANTICANCER RESEARCH   20 ( 4 )   2477 - 2483   2000年7月

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    記述言語:英語   出版者・発行元:INT INST ANTICANCER RESEARCH  

    In this study, we examined the inhibitory effects on cell growth and the effects of quercetin on intracellular accumulation of adriamycin (ADR) in wild type Ehrlich ascites tumor cells (wild EAT cells) and their ADR-resistant strain. Quercetin strongly inhibited growth in both strains. Cell growth reached a plateau at 3.5 days in the wild type EAT cells and at 7 days in the ADR-resistant strain. The inhibitory concentration in 50% of the ADR-resistant cells on day 7 (24 mu M) was twice that of the wild type EAT cells on day 4 (12 mu M) after continuous treatment with quercetin. Quercetin decreased the ADR accumulation in the wild type cells but did not affect it in the ADR-resistant cells. Further quercetin did not affect the retention of ADR in either strain. These results indicated that qeurcetin decreased ADR accumulation without extruding ADR in the wild type EAT cells. ADR accumulation in the ADR-resistant cells treated with quercetin for 7 days was increased with increasing concentrations of quercetin. Moreover ADR accumulation in the ADR-resistant cells treated with 50 mu M quercetin for 7 days, increased to 186.6% and to 181.9% of that in untreated cells after 60 minutes and 120 minutes incubation, respectively, whilst it ina-eased to 70% from 37.5% of that in the wild type EAT cells after 60 minutes incubation. These findings indicated that quercetin might reverse ADR-resistance.

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  • A case of glandular odontogenic cyst associated with ameloblastoma: correlation of diagnostic imaging with histopathological features

    M Hisatomi, J Asaumi, H Konouchi, Y Yanagi, K Kishi

    DENTOMAXILLOFACIAL RADIOLOGY   29 ( 4 )   249 - 253   2000年7月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    The glandular odontogenic cyst (GOC) is a rare odontogenic cyst. There has only been one reported case of the simultaneous presence of GOC and ameloblastoma. The radiographic features of GOC are well established but the MR findings have not been described. We report a case of GOC associated with ameloblastoma with special reference to the correlation of the diagnostic imaging with the histopathological features.

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  • Influence of bovine calf serum on the intracellular accumulation and retention of adriamycin

    JI Asaumi, H Matsuzaki, S Kawasaki, M Kuroda, Y Takeda, K Kishi, Y Hiraki

    ANTICANCER RESEARCH   20 ( 2A )   769 - 772   2000年3月

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    記述言語:英語   出版者・発行元:INT INST ANTICANCER RESEARCH  

    In this study, we observed the influence of bovine calf serum (BCS) on the intracellular accumulation of adriamycin (ADR) in Ehrlich ascites tumor cells (wild type EAT cells) and their ADR-resistant strain. The ADR accumulation treated in the medium not containing BCS was S-fold of that containing 10% BCS. ADR incorporated into cells was not effluxed in the absence of the BCS, while it was rapidly effluxed for 30 minutes to about 20% of the amount incorporated into the cells in the presence of 20% BCS in both strains. This suggests that BCS remarkably decreases the ADR accumulation due to the promotion of ADR efflux. Further; the ADR accumulation dea eased with increasing concentrations of BCS in both strains. This indicates that BCS promotes the ADR efflux, dependeing on its concentrations. BCS was heated at 100 degrees C for 7 minutes and its protein contents were degenerated. Irs influence in the ADR accumulation of wild type and ADR-resistant strain was apparent. The ADR accumulation decreased with increasing concentrations of heated BCS in both strains, as well as in the untreated BCS. Thus, the protein content of the BCS did not affect ADR accumulation. Therefore, it is necessary to investigate which components of BCS affect the promotion of ADR efflux.

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  • Assessment of secondary necrosis of Jurkat cells using a new microscopic system and double staining method with annexin V and propidium iodide

    O Honda, M Kuroda, Joja, I, J Asaumi, Y Takeda, S Akaki, Togami, I, S Kanazawa, S Kawasaki, Y Hiraki

    INTERNATIONAL JOURNAL OF ONCOLOGY   16 ( 2 )   283 - 288   2000年2月

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    記述言語:英語   出版者・発行元:PROFESSOR D A SPANDIDOS  

    Using a new system developed by us for acquiring microscopic images automatically, we compared the morphological changes that apoptotic cells undergo with changes in the staining pattern of annexin V-enhanced green fluorescent protein (AV-EGFP) and propidium iodide (PI) in individual cells. Jurkat cells were treated with 5 mM CaCl2 alone, anti-Fas antibody and heating at 42 degrees C for 30 min or 46 degrees C for 60 min, and then were incubated in medium with 5 mM CaCl2. Time-lapse DNA fragmentation analysis and morphological observation revealed that the anti-Pas antibody and heating at 42 degrees C for 30 min induced typical apoptosis in the cells, and heating at 46 degrees C for 60 min induced typical necrosis. Time-lapse observation of individual cells stained with AV-EGFP and PI confirmed that apoptotic cells were stained at first with AV-EGFP alone, and thereafter also with PI when the cellular membrane ruptured and the cell underwent secondary necrosis. Most of the cells which underwent necrosis were stained simultaneously with AV-EGFP and PI. There was a significant time interval between the staining of individual cells with AV-EGFP, indicating apoptosis, and staining of these cells with PI, which indicated the occurrence of secondary necrosis. These results suggest that time-lapse examinations are necessary to distinguish apoptosis, secondary necrosis and necrosis in cells from one another. This study presents direct evidence that apoptotic cells undergo secondary necrosis, which could be recognized with PI.

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  • Schwannoma of the upper lip: ultrasound, CT, and MRI findings.

    Asaumi J, Konouchi H, Kishi K

    J Oral Maxillofac Surg   2000年

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  • A case of glandular odontogenic cyst associated with ameloblastoma : correlation of diag nostic imaging with histopa hological features

    Dentomaxill of acial Radio logy   29 ( 4 )   249 - 253   2000年

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  • Radiographic study of the eruption of the third molar

    19 ( 1 )   155 - 137   2000年

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  • Overex pression of manganese superoxide dismutase gene suppresses spontaneous apoptosis without a resultant alteration in in vioo growth of the mouse fibrosarcoma, FSa-(]G0002[).

    Anticancer Research   20 ( 1A )   7 - 10   2000年

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  • Radiologic study of tooth root resorption in a case of squamous cell carcinoma

    Noriko KAWAI, Toru WAKASA, Jun-ichi ASAUMI, Hironobu KONOUCHI, Kanji KISHI

    Dental Radiology   40 ( 2 )   129 - 137   2000年

  • Problrm-based learning at the Okayama University Dental School

    19 ( 2 )   295 - 304   2000年

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  • 第三大臼歯の萌出に関するX線学的検討

    樋口 譲, 浅海淳一, 繁原 宏, 此内浩信, 松崎秀信, 岸 幹二

    岡山歯学   2000年

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  • 扁平上皮癌症例における歯根吸収のX線学的検討

    河井紀子, 若狭 亨, 浅海淳一, 此内浩信, 岸 幹二

    歯科放射線   2000年

  • Effects of quercetin on the cell growth and the intracellular accumulation and retention of adriamycin.

    Asaumi J, Matsuzaki H, Kawasaki S, Kuroda M, Takeda Y, Kishi K, Hiraki Y

    Anticancer Res   2000年

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  • Two cases of polyostotic eosinophilic granuloma

    Asaumi J, Konouchi H, Hisatomi M, matsuzaki H, Kishi K

    Dentomaxillofac Radiol   2000年

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  • Inhibition of thermotolerance observed on tsAF8 cells.

    Shibuya K, Kawasaki S, Kuroda M, Asaumi J, Hiraki Y

    Int J Hyperthermia   2000年

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  • A case of glandular odontogenic cyst associated with ameloblastoma: correlation of diagnostic imaging with histopathological features.

    Hisatomi M, Asaumi J, Konouchi H, Yanagi Y, Kishi K

    Dentomaxillofac Radiol   2000年

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  • 岡山大学歯学部における問題発見解決型教育法(チュートリアル教育)導入の試み

    窪木 拓男, 石川 邦夫, 新井 英雄, 吉田 登志子, 平田 あずみ, 市川 博之, 船橋 誠, 久保田 聡, 井上 正久, 谷本 一郎, 十川 紀夫, 入江 正郎, 濱 和洋, 伊東 孝介, 明貝 文夫, 浅海 淳一

    岡山歯学   2000年

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  • A radiographic study on resorption of tooth root associated with malignant

    Kawai N, Wakasa T, Asaumi J, Kishi K

    Oral radiology   2000年

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  • A radiographic study on resorption of tooth root associated with malignant tumors

    N. Kawai, T. Wakasa, J. I. Asaumi, K. Kishi

    Oral Radiology   16 ( 2 )   55 - 65   2000年

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    記述言語:英語   出版者・発行元:Japanese Soc. for Oral and Maxillofacial Radiology  

    Root resorption is a very important finding in the radiographic diagnosis of the oral and maxillofacial region. However, there are few reports about root resorption related to malignant tumors. It is a commonly accepted theory that a malignant tumor does not cause root resorption because its invasion is too rapid. However, we have encountered many unexpected cases of root resorption associated with malignant tumors. In this study, we investigated the frequency and shape of root resorption in malignant tumors and considered the relation between tumor extension and root resorption. The subjects were 72 patients with pathologically diagnosed malignant tumors. Radiography showed that the roots of their teeth were in contact or involved with the tumors. We observed the radiographs and classified the findings into 2 types as follows: (1) resorption of alveolar bone (site of tumor invasion): 1. alveolar-margin type 2. root-apex type. (2) resorption of tooth root: 1. spike type 2. knife-edge type. The root resorption rate for all cases was 43% (31/72). (There were 19 squamous cell carcinomas, 2 adenoid cystic carcinomas, 3 malignant lymphomas, 2 metastatic tumors, 1 poorly differentiated carcinoma, 3 undifferentiated carcinomas and 1 fibrosarcoma.) Root resorption rate of alveolar-margin-type tumors was 37% (19/51), and that of the root-apex-type tumors was 57% (12/21). All alveolar-margin-type tumors showed spike-type root resorption, and all root-apex-type tumors were of the knife-edge type except 1 case. Our study suggested that root resorption associated with malignant tumors is not rare and that the shape of root resorption may be related to the site of tumor invasion. In the case of root resorption with resorption of alveolar bone, it is important to take malignant tumors into consideration as well as other diseases.

    DOI: 10.1007/BF02492700

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  • Intracellular accumulation and retention of calcein in Ehrlich ascites tumor cells and their adriamycin-resistant strain

    JI Asaumi, S Kawasaki, M Kuroda, Y Takeda, K Kishi, Y Hiraki

    ANTICANCER RESEARCH   19 ( 5B )   4311 - 4314   1999年9月

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    記述言語:英語   出版者・発行元:INT INST ANTICANCER RESEARCH  

    In this study, we observed the intracellular accumulation and retention of calcein in Ehrlich ascites tumor cells (wild type EAT cells) and their adriamycin (ADR)-resistant strain to further study the mechanisms of ADR accumulation. In the wild type EAT cells, intracellular accumulation of calcein increased rapidly, but it was not incorporated into the cells in the ADR-resistant strain. This suggests that the efflux system or the inhibition system of influx, which does not exist in the wild type EAT cells, involves in the ADR- resistant strain. Calcein incorporated into the cells was effluxed from the cells in both strains at almost the same I ate. This suggests that the both strains may use a similar efflux system agaimt calcein. P-gp extrudes calcein-AM directly from the cell membrane, but not calcein. Calcein is effluxed by multidrug resistant protein (MRP) ol multispecific organic anion transporter (MOAT). Therefore, the mechanism which extrudes calcein of both strains, may be the other efflux system included MRP or MOAT apart from P-gp. In the same medium condition as treating in the calcein efflux experiments, about 20% amount of ADR incorporated into the cells was effluxed in the ADR-resistant cells, but not in the wild type cells. Since the efflux rates in the ADR differed from those in calcein in the same medium condidon, the mechanism of the ADR efflux might differ from that of calcein efflux in the ADR-resistant strain.

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  • 腎性骨異栄養症のX線学的検討

    相賀秀樹, 松崎秀信, 浅海淳一, 若狭 亨, 岸 幹二

    岡山歯学   1999年

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  • Cepharanthin enhances thermosensitivity without a resultant reduction in the thermotolerance of a murine mammary carcinoma(jointly worked)

    International Journal of Oncology   15 ( 1 )   95 - 99   1999年

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  • Influence of metabolic inhibitors on the intracellular accumulation and retention of adriamycin(jointly worked)

    Anticancer Research   19 ( 1 )   615 - 618   1999年

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  • Radioraphical study of renal osteo dy strophy

    18 ( 2 )   347 - 353   1999年

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  • Clinicoradiographic study of simple bone cyst

    18 ( 2 )   339 - 346   1999年

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  • Radiographic study of the growth of the coronoid process of the mandible

    18 ( 2 )   317 - 321   1999年

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  • Plunging ranula localiged in the pava phary nglal sapce with magnetic resonance imaging

    18 ( 2 )   365 - 369   1999年

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  • A New experimental system for irradiating tumers in mice using a linear accelerator under specific pathogen-free conditions(jointly worked)

    Acta Med Okayama   53 ( 3 )   111 - 118   1999年

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  • Influence of Metabolic Inhibitors on the Intracellular Accumulation and Retention of Adriamycin

    Jun-ici Asaumi, Shoji Kawasaki, Masahiro Kuroda, Yoshihiro Takeda, Kanji Kishi, Yoshio Hiraki

    Anticancer Res   1999年

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  • 単純性骨嚢胞の臨床学的検討

    松崎秀信, 相賀秀樹, 浅海淳一, 若狭 亨, 岸 幹二

    岡山歯学   1999年

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  • 筋突起成長・伸長に関するX線学的検討

    浅海淳一, 久富美紀, 河井紀子, 柳 文修, 此内浩信, 繁原 宏, 若狭 亨, 岸 幹二

    岡山歯学   1999年

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  • Cepharanthin enhances thermo-sensitivity without a resultant reduction in the thermotolerance of a murine mammary carcinoma

    Michinori Yamamoto, Masahiro Kuroda, Osamu Honda, Erika Ono, Jun-ichi Asaumi, Kohichi Shibuya, shoji Kawasaki, Ikuo Joja, Mitsuhiro Takemoto, Susumu Kanazawa, Yoshio Hiraki

    Int J Oncol   1999年

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  • A new experimental system for irradiating tumors in mice using a linear accelerator under specific pathogen free conditions

    Masahiro Kuroda, Keiji Inamura, Seiji Tahara, Yuzutu Kurabayashi, Tadaatsu Akagi, Junichi Asaumi, Izumi Tagami, Mitsuhiro Takemoto, Osamu Honda, Yasuyuki Morioka, Shoji Kawasaki, Yoshio Hiraki

    Acta Med Okayama   1999年

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  • Intracellular accumulation and retention of calcein Ehrlich ascites tumor cells and their adriamycin-resistant strain

    Jun-ichi Asaumi, Shoji, Kawasaki, Masahiro Kuroda, Yoshihiro Takeda, Kanji Kishi, Yoshio Hiraki

    Anticancer Res:   1999年

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  • 旁咽頭腔に進展したPlunging RanulaのMR像

    浅海淳一, 柳 文修, 久富美紀, 岸 幹二, 吉濱 泰斗, 松村智宏

    岡山歯学:   1999年

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  • Relative biological effectiveness(RBE)and potential leathal damage repair(PLDR)of heavy-ion beam

    Bull Sch Health Science, Okayama University   9 ( 1 )   75 - 81   1998年

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  • Influence of cepharanthin and hyper-thermia on the intracellular accumu-lation od adriamycin and fluo3, an indicator of Ca2<sup>+</sup>(jointly worked)

    Anticancer Res.   18 ( 3 )   1649 - 1654   1998年

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  • Influence of extracellular ion concentration on the intracellular accumulation of adriamycin(jointly worked)

    Anticancer Res.   18 ( 2 )   915 - 918   1998年

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  • Detectability of MRI in inflammation of Mandible

    17 ( 2 )   229 - 237   1998年

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  • Influence of cepharanthin on the intracellular accumulation of adriamycin in normal liver cells and splee cells of mice in vitro and in vivo(jointly worked)

    Anticancer Res.   17 ( 5 )   3617 - 3622   1997年

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  • Overexpression of manganese superoxide dismutase gene changes the metastasis associated-character of the mouse fibrosarcoma, FSa-II(jointly worked)

    Oncology Rep.   4   937 - 940   1997年

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  • Preoperative multidisciplinary treatment with hyperthermia for soft tissue Sarcoma(jointly worked)

    Acta Med Okayama   51 ( 2 )   93 - 99   1997年

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  • Influence of stage classification, tumor differentiation and mode of invasion against clinical and histopatholigical effects on low dose sequential methotrexate and 5-fluoro-uracil administration as neo-adjuvant chemotherapy for oral sequamous cell car・・・

    In Vivo   11 ( 2 )   147 - 152   1997年

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    Influence of stage classification, tumor differentiation and mode of invasion against clinical and histopatholigical effects on low dose sequential methotrexate and 5-fluoro-uracil administration as neo-adjuvant chemotherapy for oral sequamous cell carcinoma

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  • FK506 comletely inhibits adriamycin efflux in the adriamycin-resistant strain of Ehrlich ascites tumor cells(jointly worked)

    Anticancer Res.   16 ( 1 )   247 - 250   1996年

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  • Low dose sequential Methotrexate and 5-fluorouracil administration is effective and safe as neo-adjuvant chemotherapy in oral cancer(jointly worked)

    In Vivo   10 ( 6 )   559 - 562   1996年

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  • Thermosensitivity and thermotolerance on adriamycin-resistant strain of Ehrlich ascites tumor cells(jointly worked)

    Anticancer Res.   16 ( 5 )   2569 - 2573   1996年

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  • Influence of cell membrane potential, and selectivity of the Na<sup>+</sup>/H<sup>+</sup> exchanger and C1-/HC03- exchanger on the intracellular accumulation of adrimycin(jointly worked)

    Anticancer Res   16 ( 2 )   725 - 728   1996年

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  • Effect of cepharanthin and and hyperthermia on the intracellular accumulation of adriamycin in the NIH3T3 cell lines transfected with oncogenes accompanied with pSV2neo vector(jointly worked)

    Anticancer Res.   15 ( 5 )   1991 - 1996   1995年

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  • Sensitivity of anticancer drugs in NIH3TO cells trabsfected with oncogenes accompanied by pSV2neo vector(jointly worked)

    Anticancer Res.   15 ( 5 )   1911 - 1914   1995年

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  • Influence of the extracellular pH. an inhibitor of Na<sup>+</sup>/H<sup>+</sup> exchanger and an inhibitor of C1<sup>-</sup>/HCO<sub>3</sub><sup>-</sup> exchanger on adriamycin accumulation(jointly worked)

    Anticancer Res.   15 ( 1 )   71 - 76   1995年

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  • Direct antitumor effect of cepharan-thin and combined effect with adriamycin against Enrlich ascites tumor in mice(jointly worked)

    Anticancer Res.   15 ( 1 )   67 - 70   1995年

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  • Effects of hyperthermia and cepharan-thin on adriamycin accumulation with changes in extracellular pH(jointly worked)

    Int J Hyperthermia   11 ( 1 )   27 - 35   1995年

  • Effects of hyperthermia and cepharanthin on adriamycin accumulation with changes in extracellular ph

    J. Asaumi, S. Kawasaki, K. Nishikawa, M. Kuroda, Y. Htraki

    International Journal of Hyperthermia   11 ( 1 )   27 - 35   1995年

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    記述言語:英語   出版者・発行元:Informa Healthcare  

    We compared adriamycin (ADR) accumulation with the intensity of intracellular fluorescence of 3,3'-(di-n-hexyl)-2,2'-oxacarbocyanine iodide (NK-2280), an indicator of cell membrane potential, after hyperthermia and examined the effects of cepharanthin (CEP) on the accumulation of ADR and NK-2280 in wild and ADR-resistant strains of Ehrlich ascites tumour (EAT) cells. Among wild 0.2 and I-μg ADR-resistant strains of EAT cells, intracellular accumulation of both ADR and NK-2280 decreased with an increase of ADR resistance. Hyperthermia at 42°C and CEP induced a marked increase in accumulation of both ADR and NK-2280 in the ADR-resistant strains of EAT cells. The increase in ADR accumulation by hyperthermia and CEP is possibly due to an increase in the cell membrane potential and the inhibition of ADR efflux by CEP respectively. In the wild strain of EAT cells, we also evaluated the effect of extracellular pH change on ADR accumulation and the cell membrane potential and their alteration by hyperthermia and CEP. ADR accumulation decreased as pH decreased, but the cell membrane potential was not appreciably affected by pH change so far examined. Hyperthermia alone or combined with CEP significantly increased ADR accumulation in a pH range from 6.2 to 7.6. Hyperthermia increased the accumulation of ADR in the tumour cells, although its pH dependency was not completely resolved. CEP enhanced ADR accumulation more markedly in ADR-resistant cells than in wild-type cells. Therefore, the combination of hyperthermia and CEP may be very effective to increase the ADR cytotoxicity to ADR-resistant tumours. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

    DOI: 10.3109/02656739509004945

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  • Effects of amiloride derivatives on the thermosensitivity of an adriamycin -resistant strain of Ehrlich ascites tumor cells(jointly worked)

    Anticancer Res.   14 ( 3 )   805 - 808   1994年

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  • Hyperthermotherapy for postoperative local recurrences of rectal cancer(jointly worked)

    Acta Med Okayama   47 ( 4 )   249 - 254   1993年

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  • Hyperthermotherapy added to multidisciplinary therapy for penile cancer(jointly worked)

    Acta Med Okayama   47 ( 3 )   169 - 174   1993年

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  • Enhancement effect of amiloride derivative MH-12-43 on thermosensitivity of Ehrilich ascites tumor cells(jointly worked)

    Jun-ichi Asaumi, Shoji Kawasaki, Koji Nishikawa, Masahiro Kuroda, Yoshio Hiraki

    Jpn. J. Hyperthermic Oncol.   9 ( 4 )   310 - 317   1993年

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    第35回日本歯科医学教育学会総会および学術大会  2016年 

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    第35回日本歯科医学教育学会総会および学術大会  2016年 

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    第35回日本歯科医学教育学会総会および学術大会  2016年 

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    第35回日本歯科医学教育学会総会および学術大会  2016年 

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  • 口腔扁平上皮癌細胞株および口腔上皮細胞株が放出するエクソソームの解析

    第37回岡山歯学会  2016年 

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  • 転移性癌細胞株に含まれる癌幹細胞様細胞および薬剤耐性についての解析

    第39回分子生物学会年会  2016年 

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  • 3次元CT(3D-CT)の下顎角を用いた日本人の年齢推定の検討~第一報~

    NPO法人日本歯科放射線学会第21回臨床画像大会  2016年 

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  • 上顎骨内に広範囲に進展し、診断に苦慮した血管奇形の1例

    NPO法人日本歯科放射線学会第21回臨床画像大会  2016年 

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  • 癌の薬剤耐性:高転移性大腸癌細胞における抗がん剤排出ポンプの役割

    第37回岡山歯学会  2016年 

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  • Evaluation of sensitivity to Cetuximab in HNC xenograft mouse models using molecular imaging.

    The 11th Asian Congress of Oral and Maxillo Facial Radiology  2016年 

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  • Diagnostic value of FLAIR MRI for ameloblastoma including the cystic portion.

    The 11th Asian Congress of Oral and Maxillo Facial Radiology  2016年 

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  • 放射線下顎骨壊死の一例

    第60回公益社団法人 日本口腔外科学会総会・学術大会  2015年 

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  • 口腔癌マウスモデルでの抗EGFR療法における分子イメージング解析

    第69回日本口腔科学会学術集会  2015年 

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  • 顎骨の嚢胞、良性、悪性腫瘍ー最近のトピックス 顎骨病変の画像診断

    第34回日本画像医学会  2015年 

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  • 平成26年度にODAPUSプログラムで岡山大学に留学をした3か国4校の学生の意識調査

    第34回日本歯科医学教育学会総会および学術大会  2015年 

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  • 相同モデル化理論を応用した歯列石膏模型のデータ化による個人識別法の開発―第一報―

    日本法歯科医学会第9回学術大会  2015年 

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  • 顎関節部MRI検査で指摘可能であった偶発的頭蓋内病変についての臨床的検討

    NPO法人日本歯科放射線学会第56回学術大会・第12回定例総会  2015年 

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  • 口腔癌マウスモデルでのセツキシマブを用いた分子イメージング解析

    NPO法人日本歯科放射線学会第56回学術大会・第12回定例総会  2015年 

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  • X線所見不顕期を有する顎骨転移を認めた左上葉肺癌の1例

    第28回 日本口腔診断学会総会・学術大会  2015年 

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  • Verification of accuracy of cephalogram generated by MRI data processing.

    20th International Congress of Dento-Maxillo-Facial Radiology  2015年 

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  • 歯列石膏模型を利用した個人識別法の開発

    NPO法人日本歯科放射線学会第221回関東地方会・第35回北日本地方会・第23回合同地方会  2015年 

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  • 頭頸部癌マウスモデルでのセツキシマブプローブを用いた分子イメージング解析

    第36回岡山歯学会  2015年 

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  • 当院における歯科領域撮影での医療被ばくの現状

    第36回岡山歯学会  2015年 

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  • 頭頸部がんに対する放射線治療において歯科技工士の果たす役割

    第36回岡山歯学会  2015年 

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  • MRI・FLAIR 画像のエナメル上皮腫への活用

    第28回 日本口腔診断学会総会・学術大会  2015年 

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  • 当院における舌癌に対する密封小線源治療の治療成績

    第60回公益社団法人 日本口腔外科学会総会・学術大会  2015年 

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  • 新規抗癌剤KNK437による抗腫瘍増大効果・転移阻害効果に関するin vivoにおける検討

    第27回日本口腔診断学会・第24回日本口腔内科学会 合同学術大会  2014年 

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  • 静止性骨空洞のエックス線学的検討

    第27回日本口腔診断学会・第24回日本口腔内科学会 合同学術大会  2014年 

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  • Imaging diagnosis using panoramic radiograph, CT and MRI in the oral and maxillofacial region

    19th Brazilian Meeting of Oral Maxillo Facial Radiology (XIX JABRO)  2014年 

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  • 口腔領域の希少がんについて考える

    第59回 公益社団法人 日本口腔外科学会総会・学術大会  2014年 

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  • 放射線治療術後の副作用低減に努めた下口唇癌の一例

    第59回 公益社団法人 日本口腔外科学会総会・学術大会  2014年 

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  • 岡山大学病院における頭頸部がんに対するセツキシマブ併用放射線療法の初期経験

    第59回 公益社団法人 日本口腔外科学会総会・学術大会  2014年 

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  • The possibility of clinical application of cephalogram generated by MRI data processing

    The 10th Asian Congress of Oral and Maxillofacial Radiology  2014年 

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  • Mycobacterium bovis bacillus Calmette-Guérin (BCG) enhances the antitumour activity of 5-fluorouracil in the mouse oral cancer model

    The 10th Asian Congress of Oral and Maxillofacial Radiology  2014年 

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  • 顎骨病変精査中に発見された甲状腺乳頭癌の一例

    日本歯科放射線学会第19回臨床画像大会および教育研修会  2014年 

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  • 顎下腺Myoepithelial carcinomaの一例

    日本歯科放射線学会第19回臨床画像大会および教育研修会  2014年 

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  • SESSION 1 : SPECIAL LECTURE Chairperson

    The 10th Asian Congress of Oral and Maxillofacial Radiology  2014年 

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  • A case of sublingual adenoid cystic carcinoma involving mandible as a “skip lesion”

    The 10th Asian Congress of Oral and Maxillofacial Radiology  2014年 

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  • 口腔癌細胞株担癌マウスに対するBCG生菌と5-FU併用療法による延命効果の検討

    第73回日本癌学会学術大会  2014年 

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  • ⼝腔癌に対するBCG⽣菌と5-FU併⽤療法による延命効果の検討

    第68回NPO法人日本口腔科学会学術集会、  2014年 

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  • 口腔癌原発巣の進展度診断と局所再発の検出におけるMRI の役割(ワークショップ)

    第32回日本口腔腫瘍学会総会・学術大会  2014年 

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  • Dental CBCT in dental practice

    VIII Dental Scientific Meeting (TIKG) Faculty of Dentistry Hasanuddin University  2014年 

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  • エナメル上皮腫のMR診断おけるFLAIR画像の有用性

    第55回日本歯科放射線学会総会  2014年 

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  • 口腔癌細胞株担癌マウスに対するBCG生菌と5-FU併用による転移抑制と延命効果の検討

    第55回日本歯科放射線学会総会、2  2014年 

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  • 口腔癌細胞株に対する5-FU・BCG生菌併用療法の検討

    22回硬組織再生生物学会学術大会・総会  2014年 

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  • 双方向的岡山大学国際交流演習(ODAPUSプログラム)の始まり

    第33回日本歯科医学教育学会総会および学術大会  2014年 

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  • Audience Response System(クリッカー)の活用による「歯科放射線学」における参加型講義 -第2報-

    第33回日本歯科医学教育学会総会および学術大会  2014年 

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  • NPO法人日本歯科放射線学会生涯学習教育講座 通信教育レポートの結果とアンケートとの比較

    第33回日本歯科医学教育学会総会および学術大会  2014年 

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  • 上顎骨に発生した odontogenic carcinoma の 1 例

    日本歯科放射線学会第 34 回関西・九州合同地方会(第 57 回関西・第 53 回九州地方会)  2014年 

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  • 口腔癌マウスモデルでの抗 EGFR 療法の検討と分子イメージング解析

    日本歯科放射線学会第 34 回関西・九州合同地方会(第 57 回関西・第 53 回九州地方会)  2014年 

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  • Imaging diagnosis of in soft tissue lesions in the oral and maxillofacial region.

    The 12th National Congress of The Indonesian Association of Oral and Maxillofacial Surgeons  2014年 

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  • 当院における舌癌に対するCs-137治療の治療成績

    日本放射線腫瘍学会第27回学術大会  2014年 

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  • Diagnosis of TMJ using MR

    IX Brazilian Congress on Odontologic Radiology  2013年 

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  • 歯原性腫瘍の鑑別におけるダイナミックMRIの有用性

    第67回日本口腔科学会  2013年 

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  • 口腔癌原発巣の画像診断におけるMRIの役割~現状と今後の展望~

    第31回日本口腔腫瘍学会  2013年 

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  • 口腔癌に対するBCG生菌と5-FU併用療法による抗腫瘍効果の検討

    第67回日本口腔科学会  2013年 

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  • 頬骨への外力による上顎洞後壁、眼窩底骨折をきたした1例

    第67回日本口腔科学会  2013年 

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  • 口腔癌に対するBCG生菌療法による抗腫瘍、延命効果の検討

    NPO法人日本歯科放射線学会第54回総会・学術大会  2013年 

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  • A case of nasopalatine duct cyst showing an atypical shape and analysis of MR imaging of 8 nasopalatine duct cysts

    The 19th International Congress of Dento-Maxillo-Facial Radiology  2013年 

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  • 上顎残留囊胞から発生したと考えられる原発性骨内扁平上皮癌の1例

    第37回日本頭頸部癌学会  2013年 

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  • 舌リンパ節への後発転移が疑われた舌扁平上皮癌の1例

    第37回日本頭頸部癌学会  2013年 

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  • 上顎洞に発生した神経内分泌小細胞癌の一例

    NPO法人日本歯科放射線学会第54回総会・学術大会  2013年 

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  • 顎骨病変精査中に発見された甲状腺乳頭癌の一例

    第23回日本口腔内科学会、第26回日本口腔診断学会 合同学術大会  2013年 

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  • エナメル上皮腫と角化囊胞性歯原性腫瘍の鑑別におけるMRIの有用性についてー囊胞様成分のSD値の比較は鑑別に有用であるかー

    第23回日本口腔内科学会、第26回日本口腔診断学会 合同学術大会  2013年 

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  • NPO法人日本歯科放射線学会生涯学習研修会 「基本から学ぶインプラントの画像診断」におけるアンケート調査

    第32回日本歯科医学教育学会  2013年 

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  • Diagnostic value of MR imaging for dentigerous cysts.

    The 19th International Congress of Dento-Maxillo-Facial Radiology  2013年 

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  • IgG4高値を示し、診断に苦慮した顎下腺癌の1例

    第23回日本口腔内科学会、第26回日本口腔診断学会 合同学術大会  2013年 

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  • 口唇・口腔がんに対するモールドを用いた高線量率腔内密封小線源治療成績の検討

    第58回(公社)日本口腔外科学会総会・学術大会  2013年 

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  • 口腔癌に対するBCG生菌療法による抗腫瘍、延命効果の検討

    第55回歯科基礎医学会学術大会・総会  2013年 

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  • 当院での早期舌癌に対する Cs-137による組織内密封小線源治療の治療成績

    第 61 回 NPO 法人日本口腔科学会中国・四国地方部会  2013年 

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  • Quistes y tumores maxilafaciales vistos a traves de la RM

    I Congreso de la Sociedad Venezolana de Radiología e Imagenología Dentomaxilofacial  2013年 

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  • 口外法撮影における被ばく線量の検討

    第34回岡山歯学会総会・学術集会  2013年 

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  • 上顎洞原発小細胞癌と扁平上皮癌の衝突癌と考えられる一例

    第58回(公社)日本口腔外科学会総会・学術大会  2013年 

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  • 顎下部に生じた神経鞘腫の1例

    日本歯科放射線学会第33回関西・九州合同地方会  2013年 

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  • MRIによる腫瘍内液体成分の均一性比較~エナメル上皮腫と角化囊胞性歯原性腫瘍の鑑別能は向上するか?~

    第33回岡山歯学会総会・学術大会  2012年 

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  • 舌癌深達度エコー評価基準の策定

    第66回NPO法人日本口腔科学会学術集会  2012年 

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  • 口腔小唾液腺腫瘍の診断におけるdynamic MRIの有用性

    第66回NPO法人日本口腔科学会学術集会  2012年 

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  • 顎骨病変におけるMRI診断プロトコール.

    第66回NPO法人日本口腔科学会学術集会  2012年 

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  • 姫路聖マリア病院における閉塞型睡眠時無呼吸症候群(OSAS)患者の口腔内装置(ORAP)による治療状況および治療結果について

    第275回姫路聖マリア病院・神埼郡医師会症例検討会  2012年 

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  • MRI Usefulness for Differentiating Cystic-type Ameloblastomas and Keratocystic Odontogenic Tumors

    第20回IADR/LAR General Session - Iguaçu Falls, Brazil  2012年 

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  • 歯原性腫瘍のDynamic MRIにおける鑑別の有用性について

    NPO法人日本歯科放射線学会 第53回学術大会  2012年 

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  • 口腔癌に対するBCG生菌と5-FU併用療法による抗腫瘍効果の検討

    NPO法人日本歯科放射線学会 第53回学術大会  2012年 

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  • Three-dimensional Accuracy of MRI in the Field of Orthodontics.

    9th ACOMFR  2012年 

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  • Odontogenic Fibroma of the Maxilla: A case report describing its MR Iimaging Features and an Analysis of its DCE-MRI findings.

    9th ACOMFR  2012年 

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  • 顎骨内嚢胞性疾患に対する、開窓療法中の経過観察における歯科用コーンビームCTの有用性についての検討.

    第10回日本再生歯科医学会総会・学術大会  2012年 

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  • Magnetic resonance imaging diagnosis protocol for lesions of the jaw

    IX Latin American Congress of Oral and Maxillofacial Radiology  2012年 

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  • 上顎に発生した歯原性粘液腫の1例

    第57回(公社)日本口腔外科学会総会・学術大会  2012年 

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  • 含歯性嚢胞の画像診断におけるMRIの有用性

    第25回日本口腔診断学会・第22回日本口腔内科学会 合同学術大会  2012年 

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  • 非典型な形態を示した鼻口蓋管囊胞に1例

    第25回日本口腔診断学会・第22回日本口腔内科学会 合同学術会議  2012年 

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  • 磁気共鳴撮像法を用いた顎顔面骨形態の計測に関する研究.

    第22回日本歯科医学会総会  2012年 

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  • 上顎に発生した骨形成線維腫の1例 –歯原性線維腫との鑑別におけるダイナミックMRIの有用性に関する検討–.

    NPO法人歯科放射線学会 第17回臨床画像大会  2012年 

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  • 口唇・口腔がんに対するモールドを用いたIr-192高線量率密封小線源治療成績の検討

    NPO法人歯科放射線学会 第17回臨床画像大会  2012年 

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  • 頰粘膜および口唇がんに対する2ピース・モールド法を用いたIr-192高線量率密封小線源治療-第2報-.

    NPO法人歯科放射線学会 第17回臨床画像大会  2012年 

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  • 反応性骨形成を伴った下顎骨原発性骨内扁平上皮癌の一例

    NPO法人日本歯科放射線学会第32回関西・九州合同地方会  2012年 

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  • 培養細胞を用いた拡散強調画像に関するin vitro研究

    第59回NPO法人日本口腔科学会 中国・四国地方部会  2011年 

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  • 顎骨病変におけるMRI診断プロトコール

    第24回日本口腔診断学会総会・学術大会  2011年 

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  • 舌原発腺様嚢胞癌の一例

    第24回日本口腔診断学会総会・学術大会  2011年 

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  • Imaging diagnosis of odontogenic lesions at mandibular ramus. (the third report)

    The 18th International Congress of Dento-Maxillo-Facial Radiology,  2011年 

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  • NPO法人日本歯科放射線学会教育委員会歯科医師生涯学習研修会および生涯学習アンケート結果について

    第30回日本歯科医学教育学会総会・学術大会  2011年 

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  • An alternative treatment for osteoporosis with DHNA –micro CT analysis

    The 18th International Congress of Dento-Maxillo-Facial Radiology,  2011年 

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  • IDiagnostic value of dynamic contrast-enhanced MRI for unilocular cystictype ameloblastomas with homogeneously bright high signal intensity on T2-weighted or STIR MR images.

    The 18th International Congress of Dento-Maxillo-Facial Radiology,  2011年 

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  • Evaluation of the intralesional enhancement effect of Keratocystic odontogenic tumor using contrast-enhanced MRI and dynamic contrast enhanced MRI.

    The 18th International Congress of Dento-Maxillo-Facial Radiology,  2011年 

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  • 単囊胞型エナメル上皮腫と角化囊胞性歯原性腫瘍の鑑別におけるMRIの有用性について

    第16回臨床画像大会  2011年 

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  • 口蓋腫瘍の診断におけるダイナミックMRIの有用性

    第56回日本口腔外科学会総会・学術大会  2011年 

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  • 「画像診断から見た口腔病変の科学」~画像診断機器の発達と画像診断~

    第24回一般社団法人日本顎関節学会総会・学術大会  2011年 

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  • 岡山大学病院における歯科研修医を対象とした摂食・嚥下リハビリテーション研修プログラム

    第30回日本歯科医学教育学会総会・学術大会  2011年 

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  • 歯科用コーンビームCTの適正使用に行いて―被曝量と放射線防護の観点からー

    第32回岡山歯学会総会・学術大会  2011年 

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  • 造影MRIを使用した顎骨内真性囊胞内腔の造影性についての検討

    第59回NPO法人日本口腔科学会 中国・四国地方部会  2011年 

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  • 歯科用コーンビームCTの適正使用に行いて―現状と適応例についてー

    第32回岡山歯学会総会・学術大会  2011年 

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  • 当院で経験した節外性悪性リンパ腫の臨床的検討

    日本歯科放射線学会第49回九州地方会・第53回関西地方会(第30回関西・九州合同地方会)  2011年 

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  • 培養細胞を用いたADC値の成因に関するin vitro研究

    日本歯科放射線学会 第31回関西・九州合同地方会  2011年 

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  • 顎骨に発生した中心性歯原性線維腫2例のDynamic MRIに関する検討

    日本歯科放射線学会 第31回関西・九州合同地方会  2011年 

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  • 造影MRI、ダイナミックMRIを使用した歯原性囊胞内腔の造影性についての検討

    第30回日本画像医学会  2011年 

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  • Differential Diagnosis in Tumor of the Jaw

    第51回フィリピン口腔外科学会総会  2011年 

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  • 顎口腔領域における節外性悪性リンパ腫のMR像に関する検討

    第65回NPO法人日本口腔科学会学術集会  2011年 

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  • OVXマウスによる骨粗鬆症への1,4-dihydroxy-2-naphoic-acid (DHNA)を用いた治療効果の検討

    第65回NPO法人日本口腔科学会学術集会  2011年 

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  • Differential diagnosis of the lesions in the Jaw

    高雄医科大学講演  2011年 

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  • 上顎に発生したDiffuse Large B-cell lymphomaの1例

    日本歯科放射線学会第15回臨床画像大会  2010年 

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  • 上顎に発症したameloblastic carcinoma primary typeの一例

    NPO法人日本歯科放射線学会第51回学術大会  2010年 

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  • 表在組織における造影超音波検査 正常顎下リンパ節の造影超音波像

    第29回日本画像医学会  2010年 

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  • 顎顔面頸部領域CT における甲状腺偶発腫

    NPO法人日本歯科放射線学会第51回学術大会  2010年 

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  • in vitro条件下において細胞外基質を産生する象牙芽幹細胞株の樹立に関する研究

    NPO法人日本歯科放射線学会第51回学術大会  2010年 

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  • NPO法人日本歯科放射線学会第4回生涯学習研修会「基本から学ぶインプラントの画像診断」におけるアンケート調査

    第51回歯科放射線学会学術大会  2010年 

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  • Usefulness of MRI and dynamic contrast-enhanced MRI for differential diagnosis of aneurysmal bone cysts in the jaw

    12th The European Congress of Dento-Maxillo-Facial Radiology  2010年 

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  • Usefulness of MRI and dynamic contrast-enhanced MRI for differential diagnosis of simple bone cysts from true cysts in the jaw

    12th The European Congress of Dento-Maxillo-Facial Radiology  2010年 

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  • 上顎洞悪性線維性組織球腫の一例

    第23回日本口腔診断学会総会  2010年 

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  • 下顎枝に発生した歯原性病変の画像診断(第2報)

    第23回日本口腔診断学会総会  2010年 

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  • 診断に苦慮した下顎骨単房性X線透過性病変の一例

    日本歯科放射線学会第15回臨床画像大会  2010年 

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  • Mechanomyogram of lateral pterygoid muscle

    IADR 88th General Session and Exhibition 2010 Barcelona  2010年 

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  • まれな病態を呈した静止性骨空洞

    第64回NPO法人日本口腔科学会学術集会  2010年 

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  • 単嚢胞型エナメル上皮腫のMRI像の有用性の検討

    第64回NPO法人日本口腔科学会学術集会  2010年 

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  • Fundamental research regarding the factors influencing ADC in MR imaging using a bio-phantom - Basic examination of the MR imaging procedure and the changes in ADC values with cellularity -

    The 8th Asian Congress of Oral and Maxillofacial Radiology  2010年 

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  • 当院における歯科用CBCT装置の使用経験

    第31回岡山歯学会総会・学術大会  2010年 

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  • 姫路聖マリア病院における閉塞型睡眠時無呼吸症候群(OSAS)患者の口腔内装置(ORAP)による治療状況および治療結果について

    第31回岡山歯学会総会・学術集会  2010年 

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  • 上顎に発症した成人性T細胞白血病リンパ腫の1例

    日本歯科放射線学会第15回臨床画像大会  2010年 

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  • 上顎洞悪性腫瘍に対するCT検査の有用性

    第55回(社)日本口腔外科学会総会・学術大会  2010年 

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  • 第一大臼歯萠出遅延症例に対する病理学的・X線学的検討

    第55回(社)日本口腔外科学会総会・学術大会  2010年 

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  • バイオファントムを用いたADC値の成因の基礎検糖(2)-加温処理後のADC値の変化ー

    第38回日本磁気共鳴医学会大会  2010年 

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  • バイオファントムを用いたADC値の成因の基礎検討 (1)-撮像法の基礎的検討と細胞密度によるADC値の変化-

    第38回日本磁気共鳴医学会大会  2010年 

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  • Contrast-enhanced ultrasonography of submandibular lymph nodes in healthy volunteers: a preliminary study

    The 8th Asian Congress of Oral and Maxillofacial Radiology  2010年 

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  • 上顎骨に発生し非典型的な画像所見を呈したDiffuse Large B-Cell Lymphomaの1例

    第58 回NPO 法人日本口腔科学会中国・四国地方部会  2010年 

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  • 下顎骨単純性骨嚢胞における造影MRI・ダイナミックMRI の有用性に関する研究

    第58回NPO法人日本口腔科学会中国・四国地方部会  2010年 

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  • 耳下腺に発生したリンパ上皮性嚢胞の一例

    日本歯科放射線学会第49回九州地方会・第53回関西地方会(第30回関西・九州合同地方会)  2010年 

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  • in vitro study on the role of extracellular space for the alteration of apparent diffusion coefficients during apoptosis and necrosis induced by the heating treatment

    The 8th Asian Congress of Oral and Maxillofacial Radiology  2010年 

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  • 多様な病理所見を呈した頚部悪性リンパ腫の一例

    第22回日本口腔診断学会 第19回日本口腔粘膜学会  2009年 

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  • 唾液腺腫瘍におけるdynamic contrast-enhanced MRIの有用性の検討

    第63回NPO法人日本口腔科学会学術集会  2009年 

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  • Dynamic imaging of swallowing in a seated position using open-configuration MRI

    第17回国際嚥下学会  2009年 

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  • 節内全域に壊死性変化を認めた悪性リンパ腫の一例

    日本歯科放射線学会第51回関西・第48回九州合同地方会  2009年 

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  • 下顎枝に発生した歯原性病変の画像診断

    NPO法人日本歯科放射線学会 第50回記念学術大会  2009年 

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  • 1,4-dihydroxy-2-naphthoic acid(DHNA)投与による骨吸収抑制作用について

    NPO法人日本歯科放射線学会 第50回記念学術大会  2009年 

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  • 同期サンプリング法を用いたDynamic MRIによる嚥下動態の描出

    NPO法人日本歯科放射線学会 第50回記念学術大会  2009年 

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  • 頸部リンパ節腫脹の2例 ―節内性悪性リンパ腫と反応性リンパ様過形成の比較―

    NPO法人日本歯科放射線学会 第50回記念学術大会  2009年 

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  • Usefulness of MRI in the diagnosis of lesions in the jawbone

    第17回国際顎顔面放射線学会  2009年 

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  • Dynamic contrast-enhanced magnetic resonance imaging for estimating tumor proliferation and microvessel density of oral squamous cell carcinomas

    17th International Congress of Dentomaxillofacial Radiology  2009年 

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  • Dynamic MRIによる血流評価が有用であった下顎骨脈瘤性骨嚢胞の一例

    第57回NPO法人日本口腔科学会 中国・四国地方部会  2009年 

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  • 下顎第一大臼歯萌出遅延症例に対する病理学的・X線学的検討

    第30回岡山歯学会学術集会  2009年 

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  • 単純性骨嚢胞の診断における造影MRI・ダイナミックMRIの有用性に関する研究

    日本歯科放射線学会 第14回臨床画像大会  2009年 

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  • 高線量率RALSを用いたモールド法での口唇癌3例の治療経験

    第54回(社)日本口腔外科学会総会・学術大会  2009年 

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  • Differential diagnosis of oral lesions`

    XVI JABRO, Jornada da Associação Brasileira de Radiologia Odontológica.  2009年 

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  • 口唇がんおよび口角を含む頬粘膜がんに対する2 pieces type customized mold technique を使用した高線量率小線源治療

    日本歯科放射線学会 第52回関西地方会・第48回九州地方会  2009年 

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  • MRIを用いた顎骨内病変の鑑別

    第21回日本口腔診断学会学術集会  2008年 

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  • 口腔癌細胞株に対する新規抗癌剤 KNK437による血管新生阻害と癌浸潤阻害作用について

    第67回日本癌学会学術総会  2008年 

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  • Malignant fibrous histiocytoma

    The 7th Asian Congress of Oral and Maxillo-Facial Radiology (ACOMFR2008) and The 13th Annual Meeting of Clinical Diagnostics of the Japanese Society for Oral and Maxillofacial Radiology (JSOMR)  2008年 

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  • 3-D Optimal Design of Open Type Magnetic Circuit Producing Uniform Field

    The 10th Workshop on Optimization and Inverse Problems in Electromagnetism  2008年 

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  • 早期見学実習としての初診患者エスコート実習の評価 -過去3年間の検討-

    第27回日本歯科医学教育学会学術大会  2008年 

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  • 口腔癌細胞株に対する新規抗癌剤 KNK437による血管新生阻害と癌浸潤阻害作用について

    日本歯科放射線学会第49回学術大会総会  2008年 

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  • CT/MRI of the Head and Neck

    The 7th Asian Congress of Oral and Maxillo-Facial Radiology (ACOMFR2008) and The 13th Annual Meeting of Clinical Diagnostics of the Japanese Society for Oral and Maxillofacial Radiology (JSOMR)  2008年 

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  • Unilateral方式MRI用磁石の設計

    第48回日本放射線技術学会中国・四国部会学術大会 第15回日本放射線技師会中四国放射線技師学術大会 中四国放射線医療技術フォーラム  2007年 

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  • 熱ショックタンパク阻害剤KNK437による口腔癌細胞株に対する影響

    特定非営利法人日本歯科放射線学会第48回学術大会  2007年 

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  • Open-configuration MRIを用いた座位での嚥下動態の評価

    第26回日本画像医学会  2007年 

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  • MRIデータに基づいた舌・喉頭部の生理学的嚥下モデルの構築

    第26回日本画像医学会  2007年 

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  • Differential Diagnosis of Cystic Lesions in the Oral and Maxillofacial Region using MRI

    16th International Congress of Dentomaxillofacial Radiology  2007年 

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  • 開磁路型MRI装置の形状最適化に関する検討

    電気・情報関連学会中国支部第58回連合大会  2007年 

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  • 歯科用小型MRIにもちいるunilateral型磁気回路の設計

    第35回日本磁気共鳴医学会大会  2007年 

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  • Development of an MRI phantom equivalent to human tissues

    The 6th Asian Congress of Oral and Maxillo-Facial Radiology  2006年 

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  • 小児患者におけるパノラマエックス線写真のスクリーニングとしての意義

    第20日本口腔診断学会総会  2006年 

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  • 口腔癌細胞株におけるDNA修復酵素MGMTがシスプラチン感受性に及ぼす影響

    第47回日本歯科放射線学会総会  2006年 

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  • Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors

    The 6th Asian Congress of Oral and Maxillo-Facial Radiology  2006年 

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  • 早期見学実習も一環として実施された外来患者エスコート実習の評価

    第27回岡山歯学会総会  2006年 

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  • 歯学系OSCEにおける医療面接評価―教員と模擬患者の評価の信頼性とその関連性―

    第38回日本医学教育学会大会  2006年 

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  • The reliability and validity of standardized patient assessment

    84th General Session & Exhibition of the IADR  2006年 

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  • Usefulness of MRI in the Differential Diagnosis of Cystic Lesions in the Oral and Maxillofacial Region

    2005 Sino-Japanese Conference on Stomatology  2005年 

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  • 左側下顎切痕部に骨欠損を認めた神経線維腫症1型の1例

    第19回日本口腔診断学会総会  2005年 

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  • Usefulness of contrast enhanced-MRI at diagnosis of unicystic ameloblastoma

    15th International Congress of Dentomaxillofacial Radiology  2005年 

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  • Assessment of ameloblastoma using MRI and dynamic contrast-enhanced MRI

    15th International Congress of Dentomaxillofacial Radiology  2005年 

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  • 小児患者におけるパノラマエックス線写真のスクリーニングとしての意義

    第46回日本歯科放射線学会総会  2005年 

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  • 口腔癌における放射線照射、加温、および両者の併用によるNQO1遺伝子の発現の修飾とβ-lapachoneの感受性の増強効果に関する研究

    第46回日本歯科放射線学会総会  2005年 

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  • 口腔癌細胞株における加温後の熱ショック蛋白質誘導へのKNK437の影響

    第22回日本ハイパーサーミア学会  2005年 

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  • 頭頸部癌治療における温熱療法の役割

    第22回日本ハイパーサーミア学会  2005年 

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  • 舌癌における原発部ドップラー超音波画像と所属リンパ節転移の関係について

    第10回臨床画像大会  2005年 

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  • 顎関節MRIを用いた関節円板動態診断の変動と信頼性

    第18日本顎関節学会総会  2005年 

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  • 下顎骨転移性腫瘍3例のX線学的検討

    第9回臨床画像大会  2004年 

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  • Test injection用造影剤による造影効果に関する研究

    第23回日本画像医学会  2004年 

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  • 悪性リンパ腫を疑った顎下部の反応性リンパ様過形成の一例

    第9回臨床画像大会  2004年 

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  • MRIおよびdynamic MRIによるエナメル上皮腫の評価

    第17回日本口腔診断学会総会  2004年 

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  • 口蓋部腫瘍の2症例のMRIによる診断

    第17回日本口腔診断学会総会  2004年 

     詳細を見る

  • ミネソタ便り

    岡山大学第一口腔外科同門会で講演  2004年 

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  • フルオロウラシル感受性におけるO6-メチルグアニン-DNA メチルトランスフェラーゼの腫瘍内活性の影響

    第45回日本歯科放射線学会総会  2004年 

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  • 口腔顎顔面領域の上皮性嚢胞のMR像

    第44回日本歯科放射線学会総会  2003年 

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  • 頭頚部悪性リンパ腫の診断におけるdynamic contrast-enhanced MRIの有用性

    第22回日本画像医学会  2003年 

     詳細を見る

  • MR imaging of epithelial cysts of the oral and maxillofacial region

    14th International Congress of Dentomaxillofacial Radiology  2003年 

     詳細を見る

  • The value of dynamic contrast-enhanced MRI in diagnosis of malignant lymphoma of the head and neck

    14th International Congress of Dentomaxillofacial Radiology  2003年 

     詳細を見る

  • 14-3-3σ negative oral carcinomas rapidly released from radio- induced G2 arrest but did not sensitize to radiotherapy

    14th International Congress of Dentomaxillofacial Radiology  2003年 

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  • ヒト頭頸部癌細胞の温熱感受性と14-3-3σ遺伝子の関連

    日本医学放射線学会第42回生物部会学術大会  2003年 

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  • 口腔癌に対する放射線感受性における14-3-3σ 発現の影響

    第44回日本歯科放射線学会総会  2003年 

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  • 頭頸部悪性リンパ腫の画像診断におけるdynamic contrast enhanced MRIの有用性

    第44回日本歯科放射線学会総会  2003年 

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  • 口腔癌における14-3-3σ 発現がおよぼす放射線照射後の細胞周期への影響

    第62回日本癌学会総会  2003年 

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  • プロテインキナーゼ阻害剤,H89は温熱耐性発現を促進する

    日本パイパーサーミア学会第20回大会  2003年 

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  • ファージディスプレイ法を用いた口腔扁平上皮癌細胞特異的表面タンパク検出の試み

    日本歯科放射線学会第46回関西・第38回九州 合同地方会  2003年 

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  • 顎関節部MRIにおける偶発腫

    日本歯科放射線学会第36回九州・第45回関西合同地方会  2002年 

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  • MGMTプロモーター上流のメチル化による,転写およびアルキル化剤への効果について

    第20回日本口腔腫瘍 学会総会  2002年 

     詳細を見る

  • Thermoradiotherapy combined with adenoviral p53 gene therapy in head and neck carcinoma cell lines

    The 2nd Int Wokshop on Space Radiat Res The 13the Ann NASA SPAce Radiat Health Investigators' Workshop The 3rd NIRS Int'l workshop on Dose-Effect Relationship of Particulate Radiat  2002年 

     詳細を見る

  • MGMTプロモーター上流のメチル化による,転写およびアルキル化剤への効果について

    第20回日本口腔腫瘍学会総会  2002年 

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  • Methylation of O6-methylguanine-DNA Methyltransferase in upstream promoter, not in the untranslated first exon, is responsible for aberrant silencing and for biological effect against alkylating agents

    The 93rd Annual Meeting of AACR  2002年 

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  • Thermoradiotherapy combined with adenoviral p53 gene therapy in head and neck carcinoma cell lines

    The 2nd International Wokshop on Space Radiat Res The 13the Annual NASA SPAce Radiation Health Investigators' Workshop The 3rd NIRS Int'l workshop on Dose-Effect Relationship of Particulate Radiat  2002年 

     詳細を見る

  • 歯列交代期における含歯性嚢胞のエックス線学的検討

    第7回 臨床画像大会  2002年 

     詳細を見る

  • Thermoradiotherapy combined with adnoviral p53 gene therapy in head and neck carcinoma cell lines

    The 4th Asisn Congress of Oral and Maxillo-Facial Radiology  2002年 

     詳細を見る

  • Assessment of dynamic MRI of Warthin's tumors arising as multiple lesions in the parotid glands

    The 4th Asisn Congress of Oral and Maxillo-Facial Radiology  2002年 

     詳細を見る

  • Assessment of MR imaging of a solitary bone cyst

    The 4th Asisn Congress of Oral and Maxillo-Facial Radiology  2002年 

     詳細を見る

  • 舌下腺腫瘍のMRIによる評価

    第15回口腔診断学会総会  2002年 

     詳細を見る

  • 顎関節部MRI撮影時における偶発腫

    第23回岡山歯学会総会  2002年 

     詳細を見る

  • 頭頸部扁平上皮癌細胞株に対する放射線

    第43回日本歯科放射線学会総会  2002年 

     詳細を見る

  • 唾液腺腫瘍細胞株に対する保存的治療法

    第43回日本歯科放射線学会総会  2002年 

     詳細を見る

  • 温熱・放射線によるG2-blockにおける14-3-3family遺伝子の関与

    第19回日本ハイパーサーミア学会総会  2002年 

     詳細を見る

  • 頬部血管平滑筋腫の一例

    日本歯科放射線学会第36回九州・第45回関西合同地方会  2002年 

     詳細を見る

  • 頭頸部腫瘍細胞に対する温熱放射線療法

    日本歯科放射線学会 第44回関西・第34回 九州合同地方会  2001年 

     詳細を見る

  • 舌下腺腫瘍のMRIによる評価

    日本歯科放射線学会 第6回画像診断臨床大会  2001年 

     詳細を見る

  • 歯列交代期における含歯性嚢胞の臨床エックス線学的検討

    第22回岡山歯学会学会総会  2001年 

     詳細を見る

  • 歯根離開をきたした下顎歯間部における洋梨状の透過像病変

    第42回日本歯科放射線学会総会  2001年 

     詳細を見る

  • 高速撮像法によるシネMRIを用いた摂食嚥下動態の評価

    第42回日本歯科放射線 学会総会  2001年 

     詳細を見る

  • 温熱耐性抑制におけるprotein kinase阻害剤の効果

    第18回日本ハイパーサイミア学会  2001年 

     詳細を見る

  • Odontomaの臨床的X線学的分析

    第41回日本歯科放射線学会総会  2000年 

     詳細を見る

  • 基底細胞母斑症候群を疑った症例のX線学的検討

    日本歯科放射線学会第5回画像診断臨床大会  2000年 

     詳細を見る

  • オトガイ下部病変のMRIによる評価

    第41回日本歯科放射線学会総会  2000年 

     詳細を見る

  • tsAF8細胞におけるwortmanninの温熱増感と温熱耐性抑制効果

    第17回日本ハイパーサイミア学会  2000年 

     詳細を見る

  • エールリッヒ腹水癌細胞とそのアドリアマイシン耐性細胞におけるケルセチンの効果

    第54回日本口腔科学会総会  2000年 

     詳細を見る

  • Plunging ranulaに対する開窓圧迫療法

    第54回日本口腔科学会総会  2000年 

     詳細を見る

  • 腫瘍性病変,嚢胞性疾患におけるMR画像の検討

    第21回岡山歯学会総会  2000年 

     詳細を見る

  • 第三大臼歯の萌出に関するX線学的検討

    第41回日本歯科放射線学会総会  2000年 

     詳細を見る

  • MR像におけるSolitary bone cyst内部性状の考察

    日本歯科放射線学会第42回関西・第31回合同地方会  1999年 

     詳細を見る

  • 好酸球肉芽腫4症例に関する臨床的・X線学的検討

    第39回日本歯科放射線学会総会  1999年 

     詳細を見る

  • 第三大臼歯の萌出に関するX線学的検討

    第19回岡山歯学会総会  1999年 

     詳細を見る

  • Influence of bovine calf serum on the intracellular accumulation and retention of adriamycin

    International Congress of Dento-Maxillo-Facial Radiology  1999年 

     詳細を見る

  • エナメル上皮腫における造影MRIの有用性

    第40回日本歯科放射線学会総会  1999年 

     詳細を見る

  • 放射線治療後の口腔乾燥症に対し、塩酸ピロカルピン(サラジェン®)を投与しフッ素塗布を用いた口腔ケアを行った2症例

    第28回岡山歯学会総会・学術大会  0002年 

     詳細を見る

  • 残存指数・歯の残存部位と年齢の関係について

    第20回日本口腔診断学会総会  0002年 

     詳細を見る

▼全件表示

受賞

  • ポスター賞

    2010年  

     詳細を見る

    受賞国:日本国

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  • ポスター賞

    2009年  

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  • 平成19年度 日本歯科放射線学会 学会賞優秀論文賞

    2008年  

     詳細を見る

    受賞国:日本国

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共同研究・競争的資金等の研究

  • Multidisciplinary treatment on head and neck Cancer

      詳細を見る

    資金種別:競争的資金

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  • Study on influx or efflux of adryamycin

      詳細を見る

    資金種別:競争的資金

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  • Study on repair of potentially lethal damage by heavy ion irradiation

      詳細を見る

    資金種別:競争的資金

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  • Gene diagnosis and therapy of oral and maxillofacial carcinomas

      詳細を見る

    資金種別:競争的資金

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担当授業科目

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