研究者詳細 - 高尾　総司

MISC - 高尾　総司

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Individual risk alleles of susceptibility to schizophrenia are associated with poor clinical and social outcomes

Shinji Sakamoto, Manabu Takaki, Yuko Okahisa, Yutaka Mizuki, Masatoshi Inagaki, Hiroshi Ujike, Toshiharu Mitsuhashi, Soshi Takao, Masashi Ikeda, Yosuke Uchitomi, Nakao Iwata, Norihito Yamada

JOURNAL OF HUMAN GENETICS 61 ( 4 ) 329 - 334 2016年4月

記述言語：英語出版者・発行元：NATURE PUBLISHING GROUP

Many patients with schizophrenia have poor clinical and social outcomes. Some risk alleles closely related to the onset of schizophrenia have been reported to be associated with their clinical phenotypes, but the direct relationship between genetic vulnerability to schizophrenia and clinical/social outcomes of schizophrenia, as evaluated by both practical clinical scales and 'real-world' function, has not been investigated. We evaluated the clinical and social outcomes of 455 Japanese patients with schizophrenia by severity of illness according to the Clinical Global Impression-Severity Scale (CGI-S) and social outcomes by social adjustment/maladjustment at 5 years after the first visit. We examined whether 46 single nucleotide polymorphisms (SNPs) selected from a Japanese genome-wide association study of susceptibility to schizophrenia were associated with clinical and social outcomes. We also investigated the polygenic risk scores of 46 SNPs. Allele-wise association analysis detected three SNPs, including rs2623659 in the CUB and Sushi multiple domains-1 (CSMD1) gene, associated with severity of illness at end point. The severity of illness at end point was associated with treatment response, but not with the severity of illness at baseline. Three SNPs, including rs2294424 in the C6orf105 gene, were associated with social outcomes. Point estimates of odds ratios showed positive relationships between polygenic risk scores and clinical/social outcomes; however, the results were not statistically significant. Because these results are exploratory, we need to replicate them with a larger sample in a future study.

DOI： 10.1038/jhg.2015.153

高尾総司

心と社会 / 日本精神衛生会編 47 ( 2 ) 87 - 92 2016年

特集健康日本21(第2次)の初期評価健康日本21と職場における健康管理

高尾総司

保健師ジャーナル 71 ( 6 ) 480 - 484 2015年6月

記述統計の結果を報告する際の検定の扱いについて CONSORT 2010声明とSTROBE声明を踏まえて

鈴木越治, 三橋利晴, 高尾総司, 津田敏秀

産業衛生学雑誌 57 ( 臨増 ) 466 - 466 2015年5月

Social support and suicidal ideation in Japan: are home visits by commissioned welfare volunteers associated with a lower risk of suicidal ideation among elderly people in the community? (vol 49, pg 619, 2014)

Masayuki Noguchi, Toshihide Iwase, Etsuji Suzuki, Yoko Kishimoto, Soshi Takao

SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY 50 ( 3 ) 505 - 506 2015年3月

事例集新しい健康日本21へのヒント(13)地域の見守り体制をつくる : 吉備中央町におけるソーシャル・キャピタル育成の試み

野口正行, 千田政子, 伊藤しおり

保健師ジャーナル 70 ( 5 ) 418 - 422 2014年5月

Industrial distributions of severe occupational injuries among workers in Thailand. 国際誌

Michiyo Yamakawa, Pornchai Sithisarankul, Takashi Yorifuji, Sarunya Hengpraprom, Narin Hiransuthikul, Hiroyuki Doi, Soshi Takao

Journal of occupational health 55 ( 5 ) 415 - 21 2014年

記述言語：英語出版者・発行元：WILEY

BACKGROUND: In industrializing countries, occupational safety and health have been affected by globalization. However, a lack of reliable data prevents evaluation of this situation. Therefore, we examined industrial distributions and risks of severe occupational injuries among workers in Thailand, which is one of the few industrializing countries that compiles nationwide data. METHODS: Data on workers who made claims for occupational injuries from 2007 to 2009 were extracted from the Workmen's Compensation Fund records in Thailand. Among 501,334 claimants, we evaluated the industrial distributions of severe occupational injuries (i.e., permanent disability and death). We then examined the associations between industry and those injuries, using proportionate ratios (PRs) between each industrial category and the overall distribution of occupational injuries. RESULTS: The number of workers in manufacturing making claims for severe occupational injuries was the largest among all industrial categories (319,114/501,334 injuries), although the total number of occupational injuries recently declined. Additionally, workers in manufacturing experienced severe occupational injuries more often compared with the overall distribution of occupational injuries. The PRs (95% confidence interval) for manufacturing were 1.17 (1.14-1.20) in men and 1.33 (1.27-1.38) in women. After adjusting for individual characteristics, the results did not substantially change. CONCLUSIONS: Manufacturing seems to have the largest burden of occupational injuries in industrializing countries like Thailand.

DOI： 10.1539/joh.13-0085-FS

Web of Science

PubMed

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効果的な産業医研修会実施のための産業医意識実態調査-産業医研修会参加とメンタルヘルス実務に対する態度の関連について-

高尾総司, 岸本卓巳

産業衛生学雑誌 56 2014年

Type D Personality Is Associated with Psychological Distress and Poor Self-Rated Health among the Elderly: A Population-Based Study in Japan

Yosuke Kasai, Etsuji Suzuki, Toshihide Iwase, Hiroyuki Doi, Soshi Takao

PLOS ONE 8 ( 10 ) e77918-e77918 2013年10月

記述言語：英語出版者・発行元：PUBLIC LIBRARY SCIENCE

We investigated the association between Type D personality, psychological distress, and self-ratings of poor health in elderly Japanese people. In August 2010, questionnaires were sent to all residents aged >= 65 in three municipalities (n = 21232) in Okayama Prefecture, Japan, and. 13929 questionnaires were returned (response rate: 65.6%). To assess mental and physical health outcomes, we used the Kessler Psychological Distress Scale and a single item question regarding perceived general health. We analyzed 9759 questionnaires to determine odds ratios (ORs) and 95% confidence intervals (CIs) for several health outcomes, adjusting for sex, age, smoking status, frequency of alcohol consumption, overweight status, educational attainment, socioeconomic status, and number of cohabiters. The multiple imputation method was employed for missing data regarding Type D personality. The prevalence of Type D personality in our sample was 46.2%. After adjusting for covariates, we found that participants with Type D personality were at 4-5 times the risk of psychological distress, and twice the risk of poor self-rated health. This association was stronger in participants aged 65-74 years (psychological distress; OR: 5.80, 95% CI: 4.96-6.78, poor self-rated health; OR: 2.84, 95% CI: 2.38-3.38) than in those aged over 75 years (psychological distress; OR: 4.54, 95% CI: 3.96-5.19, poor self-rated health; OR: 2.05, 95% CI: 1.79-2.34). Type D personality is associated with adverse health status among Japanese elderly people in terms of mental and physical risk; therefore, further research into the implications of this personality type is warranted.

DOI： 10.1371/journal.pone.0077918

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問題発生時におけるルール・業務遂行レベルに基づくメンタルヘルス対応 (特集メンタルヘルス不調者への対応) -- (解説編)

高尾総司

月刊人事労務 25 ( 9 ) 4 - 15 2013年9月

Global perspectives on social capital and health

Ichiro Kawachi, Soshi Takao, S. V. Subramanian

Global Perspectives on Social Capital and Health 1 - 349 2013年1月

記述言語：英語出版者・発行元：Springer New York

This book is a follow up to Social Capital and Health (2008), edited by Kawachi, Subramanian and Kim. Global Perspectives on Social Capital and Health provides a timely update on emerging topics in a fast-growing field, and features contributions from an outstanding international team of scholars, selected from a diverse range of disciplinary backgrounds including: social epidemiology, medical geography, social psychology, social welfare and gerontology, pediatrics, political science, economics, and medical sociology. The book is organized in three parts: Part 1. Emerging directions in social capital research. This section highlights novel directions in social capital research. These include: a) novel settings for conducting research on social capital (workplaces, schools), b) new approaches for causal inference in social capital (instrumental variable analysis, twin fixed effects designs)
c) cutting-edge directions for social capital research, including studies of the origins of community social capital, the use of social network analysis to investigate social capital, and novel methods for investigating the link between social capital and crime. Part 2. Social capital and health policy. The three chapters in this section highlight implications of social capital for interventions and health policy. Part 3. Social capital and health in global perspective The four chapters in this section look at research on social capital and health from a global perspective. The authors summarize the empirical studies on social capital and health conducted in each country/region, or each population group
discuss how the concept of social capital translates across different cultures
and identify challenges and future directions for research.

DOI： 10.1007/978-1-4614-7464-7

Scopus

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Social cohesion and mortality: a survival analysis of older adults in Japan.

Inoue S, Yorifuji T, Takao S, Doi H, Kawachi I

Am J Public Health. 103 ( 12 ) e60-e66 2013年

職場のソーシャル・キャピタルと健康に関するレビュー

鈴木越治, OKSANEN Tuula, VAHTERA Jussi, VAHTERA Jussi, KIVIMAKI Mika, KIVIMAKI Mika, KIVIMAKI Mika, 高尾総司

産業衛生学雑誌 55 2013年

「しごとと健康」34 安全衛生管理体制と企業買収

高尾総司

健康管理 60 ( 1 ) 2013年

職場におけるソーシャル・キャピタルと健康に関する実証的研究とベンチマークシステムの構築—2011年度(第15回)研究助成「研究要旨」

小林朋子, 高尾総司, 浜田淳

Monthly IHEP ( 214 ) 28 - 30 2012年11月

日本とカンボジアの若年者におけるソーシャル・キャピタルと口腔の健康の関係

古田美智子, 野中愛恵, 江國大輔, 森田学, 高尾総司, 山下喜久

日本公衆衛生学会総会抄録集 71回 583 - 583 2012年10月

Do bonding and bridging social capital have differential effects on self-rated health? A community based study in Japan

Toshihide Iwase, Etsuji Suzuki, Takeo Fujiwara, Soshi Takao, Hiroyuki Doi, Ichiro Kawachi

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH 66 ( 6 ) 557 - 562 2012年6月

記述言語：英語出版者・発行元：BMJ PUBLISHING GROUP

Background Few studies have examined the potential difference in the relationship between bonding versus bridging social capital and health outcomes. We sought to examine the association between these different types of social capital and self-rated health in a population-based study.Methods In February 2009, 4000 residents of Okayama City (aged 20-80 y) were randomly selected for a survey on social capital and health. The survey asked about participation in six different types of associations: Parents and Teachers Association, sports clubs, alumni associations, political campaign clubs, citizen's groups and community associations. We distinguished between bonding and bridging social capital by asking participants about their perceived homogeneity (with respect to gender, age and occupation) of the groups they belonged to. ORs and 95% CIs for poor health were calculated.Results Bridging social capital (ie, participation in groups involving people from a diversity of backgrounds) was inversely associated with poor health in both sexes and women appeared to benefit more than men. Compared to those who reported zero participation, high bridging social capital was associated with a reduced odds of poor health (OR 0.25, 95% CI 0.11 to 0.55) in women after controlling for demographic variables, socioeconomic status, smoking habit and overweight. By contrast, bonding social capital was not consistently associated with better health in either gender.Conclusions The present study suggests that bonding and bridging social capital have differential associations with health and that the two forms of social capital need to be distinguished in considering interventions to promote health.

DOI： 10.1136/jech.2010.115592

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個人レベルソーシャルキャピタルと主観的不健康リソースジェネレーターを用いて

小林朋子, 岩瀬敏秀, 三橋利晴, 高尾総司, 鈴木越治

産業衛生学雑誌 54 ( 臨増 ) 503 - 503 2012年5月

日本人男性労働者における交替勤務と糖尿病の関連不定期および常時交替勤務の比較

井家克彦, 鈴木越治, 三橋利晴, 小林朋子, 高尾総司

産業衛生学雑誌 54 ( 臨増 ) 444 - 444 2012年5月

母親の労働時間と小児の過体重の関連追加報告

三橋利晴, 鈴木越治, 高尾総司, 津田敏秀, 土居弘幸

産業衛生学雑誌 54 ( 臨増 ) 362 - 362 2012年5月

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