研究者詳細 - 高尾　総司

MISC - 高尾　総司

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考察「しごとと健康」122 産業医役割の原点回帰-面接シナリオによる実現-

高尾総司, 森悠太

健康管理 67 ( 5 ) 2020年

考察「しごとと健康」119 自治体事例の類型

高尾総司, 森悠太

健康管理 67 ( 2 ) 2020年

考察「しごとと健康」126 ハイブリッド対応の問題点

森悠太, 高尾総司, 前園健司

健康管理 67 ( 9 ) 2020年

メンタルヘルス対応困難事例(新型うつを含む)を考える病名に依存しないメンタルヘルス対応

高尾総司

産業衛生学雑誌 61 ( 臨増 ) 204 - 204 2019年5月

復職時の産業医意見と人事意見の関係産業保健活動に関するニーズ調査から

高尾総司, 岸本卓巳, 勝田吉彰

産業衛生学雑誌 60 ( 臨増 ) 414 - 414 2018年5月

Relationship between pure-tone audiogram findings and speech perception among older Japanese persons

Yukihide Maeda, Soshi Takao, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Satomi Tanaka, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

Acta Oto-Laryngologica 138 ( 2 ) 140 - 144 2018年2月

記述言語：英語出版者・発行元：Taylor and Francis Ltd

Objective: To clarify how the pure-tone threshold (PTT) on the PTA predicts speech perception (SP) in elderly Japanese persons. Methods: Data on PTT and SP were cross-sectionally analyzed in Japanese persons (656 ears in 353 patients, aged ≥65 years). Correlations of SP and average PTT in all tested frequencies were evaluated by Pearson’s correlation coefficient and simple linear regression. After adjusting for sex, laterality of ears, and age, the relationship of average and frequency-specific PTT with impaired SP ≤50% was estimated by logistic regression models. Results: SP correlated well (r = −0.699) with the average PTT of all tested frequencies. On the other hand, the correlation between patient age and SP was weak, especially among ≤85-year-old persons (r = −0.092). Linear regression showed that the average PTT corresponding to SP of 50% was 76.4 dB nHL. Odds ratios for impaired SP were highest for PTT at 2000 Hz. Odds ratios were higher for middle (500, 1000, 2000 Hz) and high frequencies (4000, 8000 Hz) than low frequencies (125, 250 Hz). Conclusion: The PTT on the pure-tone audiogram (PTA) is a good predictor of SP by speech audiometry among older persons, which could provide clinically important information for hearing aid fitting and cochlear implantation.

DOI： 10.1080/00016489.2017.1378435

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健康の社会的決定要因と総合診療健康の社会的決定要因(ストレス,労働,失業)

高尾総司

ジェネラリスト教育コンソーシアム 10 2018年

地域高齢者におけるソーシャル・キャピタルと希死念慮との関連

野口正行, 小林朋子, 岩瀬敏秀, 鈴木越治, カワチイチロー, 高尾総司

日本社会精神医学会プログラム・抄録集 37th 2018年

高負荷社員のための「公平な」ストレスチェック制度の運用方法の開発と試行

高尾総司, 岸本卓巳, 野口正行, 勝田吉彰, 梅木佳則, 小島健一, 村本浩, 山本正晴, 川瀬洋平, 西浦千尋

総合健康推進財団研究報告書 2016 2018年

Risk factors for wound complications in head and neck reconstruction: 773 free jejunal reconstruction procedures after total pharyngolaryngoesophagectomy

Narushi Sugiyama, Soshi Takao, Etsuji Suzuki, Yoshihiro Kimata

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 39 ( 10 ) 2057 - 2069 2017年10月

記述言語：英語出版者・発行元：WILEY

Background: Most studies that examined risk factors for wound complications after head and neck reconstruction analyzed various complications collectively. Moreover, they included a wide variety of resection areas and reconstruction materials. To overcome these limitations, both the resection area and reconstruction method were constrained in the present study.
Methods: Patients who underwent free jejunal graft reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal cancer were enrolled. The outcomes of interest were abscesses, fistulas, and cervical skin flap necrosis.
Results: Abscesses, fistulas, and cervical skin flap necrosis developed in 19.3%, 11.3%, and 8.2% of 773 patients, respectively. A significant relationship was found between use of an open drain and abscess formation and between a longer operation time and cervical skin flap necrosis.
Conclusion: Our findings suggest that use of an open drain, cardiovascular disease, and a longer operation time are significant risk factors for abscess formation, fistula formation, and cervical skin flap necrosis, respectively.

DOI： 10.1002/hed.24874

メンタルヘルス不調者への仕事本位の対応—特集メンタルヘルス不調者対応 ; 解説編

高尾総司

月刊人事労務 29 ( 7 ) 4 - 17 2017年7月

分散事業場における円滑な事例対応のための工夫事前相談シートの活用について

友常祐介, 平岡晃, 岡部花枝, 監物友理, 高尾総司

産業衛生学雑誌 59 ( 臨増 ) 470 - 470 2017年5月

産業医活動に対する満足度と肥満・喫煙の関連性

植嶋一宗, 高尾総司

産業衛生学雑誌 59 ( 臨増 ) 396 - 396 2017年5月

Social Capital and Suicidal Ideation in Community-Dwelling Older Residents: A Multilevel Analysis of 10,094 Subjects in Japan

Masayuki Noguchi, Tomoko Kobayashi, Toshihide Iwase, Etsuji Suzuki, Ichiro Kawachi, Soshi Takao

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 25 ( 1 ) 37 - 47 2017年1月

記述言語：英語出版者・発行元：ELSEVIER SCIENCE INC

Objective: Social capital, the collective resources of groups including perceptions of trust and reciprocity, is recognized as an important contributor to suicide. We examined the association of individual-and community-level social capital with suicidal ideation after adjusting for social support among older adults living in the community. Methods: In August 2010 we sent questionnaires to all residents aged 65 years and older living in 3 rural municipalities (N = 21,232) in Okayama Prefecture, Japan; 13,919 questionnaires were returned (response rate: 65.6%). The final analysis included 10,094 participants. The outcome variable was suicidal ideation. Exposure variables were individual-level mistrust and lack of reciprocity (level 1), and the aggregated responses of these variables from 35 communities in the municipalities (level 2). Covariates included age, sex, educational attainment, marital status, the number of cohabitants, years of residence, self-rated socioeconomic status, disability, social support, and psychological distress. Multilevel logistic regression analysis was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Results: After adjusting for social support and psychological distress, we found that mistrust and lack of reciprocity were only associated with suicidal ideation at the individual level. Stratified analysis showed that among subjects with psychological distress, mistrust was associated with suicidal ideation at individual (OR: 1.88; 95% CI: 1.42-2.51) and community levels (OR: 1.98; 95% CI: 1.02-3.81). Conclusions: Our findings show that individual-and community-level social capital is a possible protective factor for suicidal ideation, particularly for people with psychological distress.

DOI： 10.1016/j.jagp.2016.10.014

Tumor-Associated Macrophages in the Development of 4-Nitroquinoline-1-Oxide-Induced Tongue Squamous Cell Carcinoma in a Mouse Model

Kentaro Miki, Yorihisa Orita, Yuka Gion, Soshi Takao, Kyotaro Ohno, Mai Takeuchi, Toshihiro Ito, Akira Minoura, Tomoyasu Tachibana, Hidenori Marunaka, Takuma Makino, Akihiro Matsukawa, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

ONCOLOGY 93 ( 3 ) 204 - 212 2017年

記述言語：英語出版者・発行元：KARGER

Objective: We aimed to determine the distribution of tumor-associated macrophages (TAMs) in the development of tongue squamous cell carcinoma (SCC) and to elucidate the role of TAMs in the progression of tongue SCC. Methods: The expression of the macrophage markers nitric oxide synthase, Retnla, and mannose receptor 1 in the development of tongue SCC was longitudinally observed using real-time quantitative polymerase chain reaction. Additionally, an immunohistochemical study using an anti-mannose receptor (MR) antibody was performed. Results: The numbers of both of M1 and M2 macrophages in the tongues of mice treated with 4-nitroquinoline-1-oxide (4NQO) were significantly lower compared with those of normal tongues. The cyclo-oxygenase-2 (COX-2) inhibitor did not prevent cancer progression and did not affect the total number of macrophages in the tongues of 4NQO-treated mice. In the immunohistochemical studies, MR staining was observed in lymphangio-endothelium in the subepithelial area of the tongues. The staining intensity of the MR was significantly stronger in the 4NQO-treated mice compared with that in control mice and 4NQO-treated mice treated with the COX-2 inhibitor. Conclusion: TAMs may not contribute to the development of 4NQO-induced tongue SCC. MR expression is associated with the progression of 4NQO-induced tongue SCC. (C) 2017 S. Karger AG, Basel

DOI： 10.1159/000477301

上司教育による労務管理的メンタルヘルス一次予防

高尾総司

日本職業・災害医学会会誌 65 2017年

扁桃周囲膿瘍における細菌学的検査の役割

橘智靖, 折田頼尚, 高尾総司, 小河原悠哉, 松山祐子, 清水藍子, 藤澤郁, 中田道広, 佐藤康晴, 西﨑和則

日本耳鼻咽喉科学会会報 120 ( 5 ) 772 - 773 2017年

The role of bacteriological studies in the management of peritonsillar abscess

Tomoyasu Tachibana, Yorihisa Orita, Soshi Takao, Yuya Ogawara, Yuko Matsuyama, Aiko Shimizu, Iku Abe-Fujisawa, Michihiro Nakada, Yasuharu Sato, Kazunori Nishizaki

AURIS NASUS LARYNX 43 ( 6 ) 648 - 653 2016年12月

記述言語：英語出版者・発行元：ELSEVIER SCI LTD

Objective: Since most patients with peritonsillar abscess (PTA) can be successfully treated with surgical drainage and empirical antibiotic therapy, routine bacteriologic studies for all patients with PTA may be unnecessary. This study tried to evaluate which patients with PTA should certainly undergo bacteriologic studies.
Methods: Hundred consecutive patients with PTA were treated and underwent culture tests of purulent contents obtained by surgical drainage between April 2008 and December 2013.
Results: In 62 of the 100 patients, 71 pathogenic bacteria were identified; 61 (86%) were Gram-positive cocci (GPC), 8 (11%) were Gram-negative rods (GNR), and 6 (8%) were anaerobes. Normal flora were isolated in 27 patients, and culture results were negative in 11 patients. Although not significant, primary (without prior antibiotic therapy) case (odds ratio (OR) = 2.19; 95% CI, 0.95-5.05) and laryngeal edema (OR = 2.04; 95% CI, 0.82-5.03) showed a tendency of associations with detection of pathogenic bacteria. After taking into account interactions between smoking habit and laryngeal edema, the covariate-adjusted OR for non-smokers with laryngeal edema was significant and showed a strong relationship (OR = 7.43; 95% confidence interval, 1.05-52.73) compared to non-smokers without laryngeal edema.
Conclusion: Although empirical antibiotic therapy was effective for most of the PTA patients, bacteriologic studies might be indispensable for the patients with laryngeal edema considering the failure of the first treatments. Particularly, the culture tests may be useful for non-smokers with laryngeal edema. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.anl.2016.01.009

Regulatory T cells function at the early stage of tumor progression in a mouse model of tongue squamous cell carcinoma

Kentaro Miki, Yorihisa Orita, Yuka Gion, Soshi Takao, Kyotaro Ohno, Mai Takeuchi, Toshihiro Ito, Hiroyuki Hanakawa, Tomoyasu Tachibana, Hidenori Marunaka, Takuma Makino, Akira Minoura, Akihiro Matsukawa, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

CANCER IMMUNOLOGY IMMUNOTHERAPY 65 ( 11 ) 1401 - 1410 2016年11月

記述言語：英語出版者・発行元：SPRINGER

The objective of this study was to observe the distribution of regulatory T cells (Tregs) in the development of tongue squamous cell carcinoma (SCC) and to determine the role of Tregs in the progression of tongue SCC. A mouse model of 4-nitroquinoline-1-oxide (4NQO)-induced-tongue SCC was established. The expression of Forkhead box P3 (Foxp3), interleukin 10, transforming growth factor-beta, chemokine CC motif ligands 17, 20, and CC chemokine receptor 4 was determined using real-time quantitative polymerase chain reaction. Foxp3 expression was also analyzed using immunohistochemistry. The results were compared with those of control mice and of 4NQO-treated mice treated with a cyclooxygenase-2 (COX-2) inhibitor. Well to moderately differentiated tongue SCC was induced in all of the experimental mice. The amount of Tregs of the experimental mice was over 10 times as much as control mice at the early stage of tumor progression. COX-2 inhibitor did not prevent the progression of tongue SCC and did not reduce the total amount of Tregs. Tregs function at the early stage of the development of tongue SCC, and it may be effective to suppress Tregs at the early stage of tumor progression for the treatment and/or prevention of tongue SCC.

DOI： 10.1007/s00262-016-1902-x

特集現場が主導するメンタルヘルス対策 : 書式活用による業務標準化のメリット

高尾総司

ビジネスガイド 53 ( 12 ) 19 - 33 2016年9月

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