Faculty Profiles - TERATO Hiroaki

MISC - TERATO Hiroaki

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Repair roles of hSMUG1 assessed by damage specificity and cellular activity. International journal

Aya Masaoka, Mayumi Matsubara, Tamon Tanaka, Hiroaki Terato, Yoshihiko Ohyama, Kihei Kubo, Hiroshi Ide

Nucleic acids research. Supplement (2001) 3 263 - 264 2003

Language：English

Single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1) was previously identified as a putative backup enzyme of major mammalian uracil-DNA glycosylase (UDG). However, the subsequent studies have shown conflicting results about the substrate specificity of SMUG1. In the present study, to clarify the repair role of SMUG1, we determined the damage specificity of purified human SMUG1 (hSMUG1) and its contribution to repair of oxidized bases in HeLa cell extracts.

PubMed

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Identification and characterization of mammalian 5-formyluracil-DNA glycosylase. International journal

Mayumi Matsubara, Aya Masaoka, Tamon Tanaka, Hiroaki Terato, Yoshihiko Ohyama, Hiroshi Ide

Nucleic acids research. Supplement (2001) 3 233 - 234 2003

Language：English

5-Formyluracil is a major oxidative thymine lesion with mutagenic and cytotoxic properties. In this study, we have partially purified and characterized a mammalian 5-formyluracil-DNA glycosylase (FDG) from rat liver. FDG was a monofunctional DNA glycosylase and removed 5-formyluracil, uracil, 5-hydroxyuracil, 5-hydroxylmethyluracil in single-stranded and double-stranded DNA. Several lines of evidence indicate that FDG is a rat SMUG1 homologue. Human SMUG1 also exhibited similar enzymatic properties.

PubMed

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Repair of oxidative cytosine damage by DNA glycosylases International journal

Atsushi Katafuchi, Aya Matsuo, Hiroaki Terato, Yoshihiko Ohyama, Hiroshi Ide

Nucleic Acids Research Supplement 3 269 - 270 2003

Language：English

5-Hydroxyuracil (HOU) and 5-hydroxycytosine (HOC) are major oxidative lesions of cytosine with mutagenic potentials. Therefore, HOU and HOC need to be removed from DNA to avoid mutation. In this study, oligonucleotide substrates containing HOU and HOC were synthesized by DNA polymerase reactions and tested for DNA glycosylases. Ung exhibited an extremely low activity for HOU as compared to uracil (U). In contrast, hSMUG1 excised HOU and U with a comparable efficiency. Ung and hSMUG1 did not excise HOC.

PubMed

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89 Identification of a Mammalian 5-Formyluracil-DNA Glycosylase and its Substrate Recognition Mechanism(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) :

TANAKA Tamon, MATSUBARA Mayumi, MASAOKA Aya, KUBO Kihei, TERATO Hiroaki, OHYAMA Yoshihiko, IDE Hiroshi

Journal of radiation research 44 ( 4 ) 408 - 408 2003

201 The Repair Mechanism of a Crosslink Lesion of Oxanine Generated by NO(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) :

NAKANO Toshiaki, SIMIZU Ryoko, TERATO Hiroaki, BENNET Houten, IDE Hiroshi

Journal of radiation research 44 ( 4 ) 436 - 436 2003

202 Quantitation of DNA damage induced by high LET particles(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) :

TANAKA Ruri, NAKAARAI Yusuke, TERATO Hiroaki, FURUSAWA Yoshiya, IDE Hiroshi

Journal of radiation research 44 ( 4 ) 436 - 436 2003

Detection of NO-induced DNA lesions by the modified aldehyde reactive probe (ARP) assay. International journal

Toshiaki Nakano, Hiroaki Terato, Yoshihiro Yoshioka, Yoshihiko Ohyama, Kihei Kubo, Hiroshi Ide

Nucleic acids research. Supplement (2001) 2 239 - 240 2002

Purification of a Repair Enzyme for 5-Formyluracil :

MATSUBARA Mayumi, TANAKA Tamon, MASAOKA Aya, KUBO Kihei, TERATO Hiroaki, OHYAMA Yoshihiko, IDE Hiroshi

Journal of radiation research 43 ( 4 ) 446 - 446 2002

Translesion DNA Synthesis Past a FapyG Lesion by E. coli DNA Polymerase I :

ASAGOSHI Kenjiro, TERATO Hiroaki, OHYAMA Yoshihiko, IDE Hiroshi

Journal of radiation research 43 ( 4 ) 448 - 448 2002

Adduct formation between oxanine and amine derivatives.

Nakano, T., Terato, H., Asagoshi, K., Ohyama, Y., Suzuki, T., Yamada, M., Makino, K., Ide, H.

Nucleic acids research. Supplement (2001) 1 ( 1 ) 47 - 48 2001

Quantitation of DNA damage by an aldehyde reactive probe (ARP).

Kurisu, S., Miya, T., Terato, H., Masaoka, A., Ohyama, Y., Kubo, K., Ide, H.

Nucleic acids research. Supplement (2001) 1 ( 1 ) 45 - 46 2001

Mechanism to maintain genetic information in Halobacterium salinarium, a halophilic bacterium.

Terato, H, Asgarani, E, Funamizu, H, Saito, T, Shahmohammadi, H. R, Ide, H

Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis 2001

Recognition of 5-Formyluracil by Repair Enzymes for Oxidative Damage :

MASAOKA Aya, HASEGAWA Rei, MATSUBARA Mayumi, TERATO Hiroaki, OHYAMA Yoshihiko, IDE Hiroshi

Journal of radiation research 42 ( 4 ) 482 - 482 2001

Detection of Radiation-Induced DNA Damage by an Aldehyde Reactive Probe (ARP) :

TERATO Hiroaki, KURISU Satofumi, MIYA Toshinobu, ALI Mohammed Mohsin, OHYAMA Yoshihiko, KUBO Kihei, IDE Hiroshi

Journal of radiation research 42 ( 4 ) 465 - 465 2001

Enzymatic properties of Escherichia coli and human 7, 8-dihysro-8-oxoguanine DNA glycosylase.

Asagoshi, K., Yamada, T., Terato, H., Ohyama, Y. and Ide, H.

44 11 - 12 2000

DNA protection ability of intracellular highly concentrated salts on Halobacterium salinarium, an extremely halophilic bacterium

H Terato, E Asgarani, HR Shahmohammadi, H Funamizu, T Saito, H Ide

8TH WORLD SALT SYMPOSIUM, VOLS 1 AND 2 927 - 931 2000

Authorship：Lead author,　Corresponding author Language：English Publisher：ELSEVIER SCIENCE BV

Halobacterium salinarium is an extremely halophilic archaebacterium, which lives in the surface of salt lake and salt plant. In these environments, H. salinarium is usually exposed by intense irradiation of sunlight including ultraviolet light (UV). UV produces DNA lesions, and possesses mutagenic and/or lethal effects on organisms. H. salinarium can tolerant various DNA-damaging agents such as UV and gamma rays. H. salinarium contains saturated concentrations of K+ and Cl- in the cell. Since Cl- is known to be a radical scavenger, the intracellular highly accumulated ions seem to be involved in the DNA protection. In vitro, highly concentrated KCI inhibited the generations of cyclobutane pyrimidine dimer (CPD) and DNA strand break, the DNA lesions induced by UV and gamma rays, respectively. These protection efficiencies are larger than that shown by carotenoid, an abandon antioxidant in the cell of H. salinarium. Therefore the intracellular highly concentrated salts play effective role not only to tolerant against osmotic pressure, but also to maintain the genetic information in the extremely severe environment.

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Preparation and enzymatic recognition of guanine lesions induced by nitrogen oxides.

Masaoka, A., Terato, H., Honsho, A., Ohyama, Y., Suzuki, T., Yamada, M., Makino, K. and Ide, H.

44 87 - 88 2000

Substrate Specificities of Endonuclease III Homologues :

ODAWARA Hiroaki, MIYANO Takayuki, TERATO Hiroaki, OHYAMA Yoshihiko, IDE Hiroshi

Journal of radiation research 41 ( 4 ) 423 - 423 2000

Recognition of Formamidopyrimidine by Endonuclease III Homologues :

ASAGOSHI Kenjiro, YAMADA Takao, OKADA Yumiko, TERATO Hiroaki, OHYAMA Yoshihiko, YAMAMOTO Kazuo, IDE Hiroshi

Journal of radiation research 41 ( 4 ) 422 - 422 2000

Preparation of DNA containing 7-methylguanine as unique lesions.

Asagoshi, K., Terato, H., Ohyama, Y. and Ide, H.

42 83 - 84 1999

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