2024/02/20 更新

写真a

オザキ トシフミ
尾﨑 敏文
OZAKI Toshifumi
所属
医歯薬学域 教授
職名
教授
外部リンク

学位

  • 医学博士 ( 岡山大学 )

  • 博士(医学) ( 岡山大学 )

研究キーワード

  • 整形外科

  • Bone and soft tissue Tumor Spine

  • 脊椎

  • 骨軟部腫瘍

研究分野

  • ライフサイエンス / 整形外科学

経歴

  • 岡山大学学術研究院医歯薬学域   教授

    2021年

      詳細を見る

  • - 岡山大学 副病院長(診療担当)

    2017年 - 2019年

      詳細を見る

  • 岡山大学

    2016年 - 2017年

      詳細を見る

  • 岡山大学   Okayama University Hospital

    2013年 - 2016年

      詳細を見る

  • - 岡山大学医歯薬学総合研究科 教授

    2005年

      詳細を見る

  • - Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2005年

      詳細を見る

  • Senior Assistant Professor,Faculty of Medicine,Medical School,Okayama University

    2002年 - 2005年

      詳細を見る

  • 岡山大学   Medical School, Faculty of Medicine

    2002年 - 2005年

      詳細を見る

  • Research Associate,Faculty of Medicine,Medical School,Okayama University

    1996年 - 2002年

      詳細を見る

  • 岡山大学   Medical School, Faculty of Medicine

    1996年 - 2002年

      詳細を見る

▼全件表示

所属学協会

▼全件表示

委員歴

  • 日本骨・関節感染症学会   理事  

    2023年6月   

      詳細を見る

  • 岡山大学医師会   会長  

    2023年   

      詳細を見る

  • 国立研究開発法人量子科学技術研究開発機構QST病院   QST病院重粒子線治療臨床研究検討会骨軟部腫瘍班会議委員  

    2021年11月 - 2023年3月   

      詳細を見る

  • 日本年金機構 障害年金センター   国民年金・特別障害給付金障害認定審査委員  

    2021年4月 - 2022年3月   

      詳細を見る

  • 日本骨・関節感染症学会   監事  

    2021年 - 2023年6月   

      詳細を見る

  • 国立研究開発法人量子科学技術研究開発機構QST病院   重粒子線治療多施設共同臨床研究組織(J-CROS)運営委員会骨軟部腫瘍分科会委員  

    2020年4月 - 2022年3月   

      詳細を見る

  • 岡山県医師会   理事  

    2018年 - 2022年6月   

      詳細を見る

  • 日本整形外科学会   理事  

    2017年 - 2019年   

      詳細を見る

    団体区分:学協会

    日本整形外科学会

    researchmap

  • - 日本臨床腫瘍グループ(JCOG) 代表(2017-)  

    2017年   

      詳細を見る

  • 日本骨折治療学会   評議員  

    2017年   

      詳細を見る

    団体区分:学協会

    日本骨折治療学会

    researchmap

  • - 日本小児がん研究グループ(JCCG) 理事(2015-)  

    2015年 - 2019年   

      詳細を見る

  • 日本股関節学会   評議員  

    2015年   

      詳細を見る

  • 日本軟骨代謝学会   理事  

    2014年   

      詳細を見る

    団体区分:学協会

    日本軟骨代謝学会

    researchmap

  • - 日韓整形外科シンポジウム 理事(2014-)  

    2014年   

      詳細を見る

  • ISOLS   理事  

    2013年   

      詳細を見る

    団体区分:学協会

    ISOLS

    researchmap

  • 日本ユーイング肉腫研究グループ(JESS)   代表  

    2013年   

      詳細を見る

    団体区分:学協会

    日本ユーイング肉腫研究グループ(JESS)

    researchmap

  • 日本癌治療学会   代議員  

    2013年   

      詳細を見る

    団体区分:学協会

    日本癌治療学会

    researchmap

  • 日本運動器科学会   理事  

    2013年   

      詳細を見る

    団体区分:学協会

    日本運動器科学会

    researchmap

  • 日本軟骨代謝学会   評議員  

    2013年   

      詳細を見る

    団体区分:学協会

    日本軟骨代謝学会

    researchmap

  • 日本人工関節学会   評議員  

    2013年   

      詳細を見る

    団体区分:学協会

    日本人工関節学会

    researchmap

  • 日本リウマチ学会   評議員  

    2013年   

      詳細を見る

    団体区分:学協会

    日本リウマチ学会

    researchmap

  • 日本リハビリテーション医学会   代議員  

    2012年   

      詳細を見る

    団体区分:学協会

    日本リハビリテーション医学会

    researchmap

  • 日本関節病学会   理事  

    2012年   

      詳細を見る

    団体区分:学協会

    日本関節病学会

    researchmap

  • 日本整形外科スポーツ医学会   代議員  

    2011年   

      詳細を見る

    団体区分:学協会

    日本整形外科スポーツ医学会

    researchmap

  • - 日本運動器移植・再生医学研究会 代表幹事(2011-)  

    2011年   

      詳細を見る

  • - 日本リウマチ学会 評議員(2010-)  

    2010年   

      詳細を見る

  • - 日本リウマチ学会中国・四国支部 評議員(2010-)  

    2010年   

      詳細を見る

  • 日本リハビリテーション医学会   評議員  

    2009年   

      詳細を見る

    団体区分:学協会

    日本リハビリテーション医学会

    researchmap

  • APMSTS   理事  

    2008年   

      詳細を見る

    団体区分:学協会

    APMSTS

    researchmap

  • 日本小児整形外科学会   評議員  

    2008年   

      詳細を見る

    団体区分:学協会

    日本小児整形外科学会

    researchmap

  • 日本バイオメカニクス学会   評議員  

    2007年   

      詳細を見る

    団体区分:学協会

    日本バイオメカニクス学会

    researchmap

  • 日本整形外科学会   代議員  

    2007年   

      詳細を見る

    団体区分:学協会

    日本整形外科学会

    researchmap

  • 日本骨・関節感染症研究会   評議員  

    2006年   

      詳細を見る

    団体区分:学協会

    日本骨・関節感染症研究会

    researchmap

  • 日本関節病学会   評議員  

    2006年   

      詳細を見る

    団体区分:学協会

    日本関節病学会

    researchmap

  • 中国・四国整形外科学会   理事  

    2005年   

      詳細を見る

    団体区分:学協会

    中国・四国整形外科学会

    researchmap

  • 中部日本整形外科災害外科学会   評議員  

    2003年   

      詳細を見る

    団体区分:学協会

    中部日本整形外科災害外科学会

    researchmap

  • 中部日本整形災害外科学会   評議員  

    1999年   

      詳細を見る

    団体区分:学協会

    中部日本整形災害外科学会

    researchmap

▼全件表示

 

論文

  • Longitudinal changes in medial knee joint space narrowing after medial meniscus posterior root repair: A 2-year follow-up study. 国際誌

    Koki Kawada, Takayuki Furumatsu, Masanori Tamura, Naohiro Higashihara, Yusuke Yokoyama, Toshifumi Ozaki

    The Knee   47   92 - 101   2024年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Despite good clinical results, repair of medial meniscus (MM) posterior root tears (MMPRTs) may not completely prevent knee osteoarthritis progression. This study evaluated changes in the medial joint space (MJS) during the first and second years after repair, compared to narrowing in the contralateral knee, using fixed-flexion view (FFV) radiographs. METHODS: Fifty-four patients who underwent pull-out repair for a unilateral MMPRT were included. FFV radiographs were obtained pre-operatively and at the 1- and 2-year post-repair timepoints to evaluate changes in the MJS and Kellgren-Lawrence grade bilaterally. Clinical outcomes were also evaluated. RESULTS: The change in the MJS was greater in MMPRT knees than in contralateral knees during the first year (0.48 ± 0.80 mm vs. 0.09 ± 0.49 mm, p < 0.001), but this difference lessened in the second year (0.09 ± 0.36 mm vs. 0.07 ± 0.38 mm, p = 0.285). Kellgren-Lawrence grade progression in MMPRT knees was less in the second year. Clinical outcomes significantly improved at both 1 and 2 years post-repair than the pre-operative values (p < 0.001), with continued improvement in clinical outcomes in the second year. There was no significant correlation between patient characteristics and the change in the MJS from preoperatively to 2 years postoperatively. CONCLUSION: Pull-out repair for MMPRTs did not completely prevent MJS narrowing, but the rate of narrowing decreased in the second year (mean, 0.09 mm) compared to that in the first year (mean, 0.48 mm). MJS narrowing in the second year after MM posterior root repair was comparable to that of the contralateral knee. Clinical outcomes further improved over the second year after repair. LEVEL OF EVIDENCE: IV.

    DOI: 10.1016/j.knee.2024.01.005

    PubMed

    researchmap

  • Initial tension at suture fixation affects the suture breakage following medial meniscus posterior root repair: a retrospective cohort study. 国際誌

    Masanori Tamura, Takayuki Furumatsu, Yusuke Yokoyama, Naohiro Higashihara, Koki Kawada, Toshifumi Ozaki

    Journal of ISAKOS : joint disorders & orthopaedic sports medicine   2024年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: This study aimed to investigate whether the initial suture tension when pullout sutures are fixed affects postoperative clinical outcomes following medial meniscus posterior root repair. METHODS: The data of 48 patients who underwent transtibial pullout repair using two simple stitches (outer and inner sutures) with an additional all-inside posteromedial pullout were retrospectively investigated. The patients were sequentially divided into two groups to compare the clinical efficacy of the initial pullout tension when pullout sutures were fixed: the 30N Group (April 2019 to September 2019, 24 patients) and the 15N group (October 2019 to February 2020, 24 patients). The rate of suture breakage (suture cutout or rupture) at the second-look arthroscopy at 1 year postoperatively and clinical outcomes at 2 years postoperatively were compared between the two groups. RESULTS: In both groups, each clinical score significantly improved at 2 years postoperatively. At the second-look arthroscopy, the rate of posteromedial suture breakage was significantly higher in the 30 N Group (19 patients, 79%) than in the 15 N Group (10 patients, 42%); the rate of outer suture breakage was also higher in the 30 N group (five patients, 21%) than in the 15 N group (no patients). On comparing 2 years of preoperative clinical scores between the groups categorized according to posteromedial suture breakage, the pain score was significantly higher in the suture breakage group. CONCLUSION: The initial tension of pullout repair of the medial meniscus posterior root tear is related to suture breakages. To prevent suture breakage, 15 N is a more initially suitable condition than 30 N. LEVEL OF EVIDENCE: Level III.

    DOI: 10.1016/j.jisako.2024.01.004

    PubMed

    researchmap

  • Intercondylar notch width and osteophyte width impact meniscal healing and clinical outcomes following transtibial pullout repair of medial meniscus posterior root tears. 国際誌

    Takaaki Hiranaka, Takayuki Furumatsu, Yusuke Yokoyama, Naohiro Higashihara, Masanori Tamura, Koki Kawada, Haowei Xue, Toshifumi Ozaki

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA   32 ( 1 )   116 - 123   2024年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: This retrospective study aimed to investigate the relationship between intercondylar notch width (ICNW), osteophyte width (OW), and the healing of medial meniscus posterior root tears (MMPRTs) following arthroscopic pullout repair. METHODS: The study included 155 patients diagnosed with MMPRTs who underwent transtibial pullout repair. Meniscal healing status was evaluated on second-look arthroscopy using a previously reported meniscus healing score. Patients were divided into two groups based on this score: the high healing score (group HH, healing score ≥ 8 points) and suboptimal healing score (group SO, healing score ≤ 6 points) groups. Computed tomography scans were performed on patients 1 week postsurgery. ICNW and OW widths were measured and relatively evaluated based on their ratio to the intercondylar distance (ICD), represented as the ICNW/ICD ratio (%) and OW/ICD ratio (%), respectively. Patient-reported outcomes were assessed preoperatively and on second-look arthroscopy using the Knee injury and Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS). RESULTS: There were no significant demographic differences between the SO and HH group (n = 35 and 120 patients, respectively). Regarding radiographic measurements, significant differences were observed in the ICNW/ICD ratio (group SO, 24.2%; group HH, 25.2%; p = 0.024), OW (group SO, 2.6 mm; group HH, 2.0 mm; p < 0.001), and OW/ICD ratio (group SO, 3.5%; group HH, 2.7%; p < 0.001). Both groups had similar preoperative clinical scores, but postoperative clinical scores, including KOOS-activities of daily living (group SO, 83.4; group HH, 88.7; p = 0.035) and VAS (group SO, 19.1; group HH, 11.3; p = 0.005), were significantly better in group HH. CONCLUSION: The study suggests that ICNW and OW may play a crucial role in MMPRT healing following arthroscopic pullout repair, as evidenced by the worse clinical outcomes associated with a narrower ICNW and wider OW. These findings highlight the potential significance of ICNW and OW assessments when evaluating meniscal repair indications. LEVEL OF EVIDENCE: Level III.

    DOI: 10.1002/ksa.12032

    PubMed

    researchmap

  • Weight loss enhances meniscal healing following transtibial pullout repair for medial meniscus posterior root tears. 国際誌

    Takaaki Hiranaka, Takayuki Furumatsu, Yusuke Yokoyama, Naohiro Higashihara, Masanori Tamura, Koki Kawada, Toshifumi Ozaki

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA   32 ( 1 )   143 - 150   2024年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: This study investigated the impact of weight change on the success of transtibial pullout repair for medial meniscus (MM) posterior root tears (MMPRTs). METHODS: The study included 129 patients diagnosed with MMPRTs who had undergone transtibial pullout repair. The patients were screened between July 2018 and November 2021. Patient-reported outcomes were assessed preoperatively and at 12 months postoperatively using the Knee injury and Osteoarthritis Outcome Score (KOOS). MM extrusion (MME) and ΔMME (postoperative MME - preoperative MME) were calculated preoperatively and at 12 months postoperatively using magnetic resonance imaging. RESULTS: Patients were divided into weight loss (body mass index [BMI] decrease of at least 0.5 kg/m2 after primary repair; n = 63) and weight gain (BMI increase of at least 0.5 kg/m2 ; n = 66) groups. Both groups had similar demographic variables and preoperative clinical scores; patient-reported outcomes significantly improved postoperatively. The weight loss group had significantly greater improvement in KOOS-quality of life (weight loss, 29.4 ± 23.7; weight gain, 23.9 ± 27.6; p = 0.034), lower postoperative MME (weight loss, 3.9 ± 1.7 mm; weight gain, 4.2 ± 1.2 mm; p = 0.043) and lower ΔMME (weight loss, 0.8 ± 0.8 mm; weight gain, 1.2 ± 0.9 mm; p = 0.002) than the weight gain group. Total arthroscopic healing scores (weight loss, 7.6 ± 1.0; weight gain, 7.2 ± 1.5; p = 0.048) and associated subscales, including anteroposterior bridging tissue width (weight loss, 4.0 ± 0.0; weight gain, 3.8 ± 0.7; p = 0.004) and MM posterior root stability (weight loss, 2.6 ± 0.7; weight gain, 2.4 ± 0.7; p = 0.041), significantly differed between the groups. CONCLUSIONS: Weight loss was associated with better meniscal healing and less MME progression after MMPRT repair, highlighting the significance of weight management in individuals undergoing meniscal surgery. These findings provide valuable insights into the clinical significance of weight loss in the success of transtibial pullout repair for MMPRTs. LEVEL OF EVIDENCE: Level III.

    DOI: 10.1002/ksa.12037

    PubMed

    researchmap

  • Ideal insertion point and projection of the infra-acetabular screw in acetabular fracture surgery. 国際誌

    Shiro Fukuoka, Masanori Yorimitsu, Takenori Uehara, Shuichi Naniwa, Toshiaki Hata, Kohei Sato, Tomoyuki Noda, Toru Sato, Toshifumi Ozaki

    Injury   111264 - 111264   2023年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: In acetabular fracture surgery, an infra-acetabular screw (IAS) is inserted from the anterior to the posterior column through the infra-acetabular corridor to stabilize both columns. Although the IAS is useful for increasing fixation strength, proper placement requires proficiency and often results in extraosseous screw penetration. The complex anatomy of the infra-acetabular corridor and difficult intraoperative detection of the ideal insertion point and angle make proper placement of the IAS challenging. This study aimed to detect the ideal insertion point and angle of the IAS based on anatomical landmarks that can be directly identified intraoperatively. METHODS: We retrospectively reviewed the pelvic CT of 50 adults who underwent serial slice CT imaging. The pelvic inlet plane (PIP), which contains the anterior border of both the sacroiliac joint and posterior superior edge of the pubic symphysis, was used as the reference plane for the pelvic coordinate system to simulate the ideal insertion of IAS. The distance from the posterior superior edge of the pubic symphysis to the ideal insertion point of the IAS (IAS distance) and the angle and length of the IAS that could be inserted from the ideal insertion point were measured. RESULTS: The mean IAS distance was 61.0 ± 5.7 mm (57.6 ± 4.3 mm in men and 64.4 ± 4.9 mm in women). The mean angle between ideal IAS and yz-plane on the outlet view (α-angle) was 8.4 ± 6.6 ° (6.4 ± 5.6° in men and 10.5 ± 7.0° in women). The mean angle between ideal IAS and y-axis on the yz-plane (β-angle) was 86.5 ± 10.6 ° (86.0 ± 10.3° in men and 87.0 ± 10.9° in women). The length of IAS was 97.1 ± 4.7 mm in men and 89.2 ± 3.6 mm in women. CONCLUSION: The IAS ideal insertion point detected as a distance from the pubic symphysis may aid in the proper insertion of the IAS during surgery. The insertion angle was parallel or tilted 10 ° laterally to the longitudinal axis in the pelvic outlet plane and almost perpendicular to the PIP in the sagittal plane when inserted from the ideal insertion point.

    DOI: 10.1016/j.injury.2023.111264

    PubMed

    researchmap

  • The Effectiveness of Rehabilitation after Open Surgical Release for Trigger Finger: A Prospective, Randomized, Controlled Study

    Taichi Saito, Ryo Nakamichi, Ryuichi Nakahara, Keiichiro Nishida, Toshifumi Ozaki

    Journal of Clinical Medicine   12 ( 22 )   7187 - 7187   2023年11月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Background: It is not clear whether rehabilitation after surgery for trigger finger is effective. The aim of this study was to reveal its effectiveness for trigger finger. Methods: This study was a randomized, controlled trial that included patients who underwent operations for trigger fingers. The patients in the rehabilitation group had postoperative occupational therapy (OT) for 3 months, while the patients in the control group were not referred for rehabilitation but received advice for a range of motion exercises. We evaluated the severity of trigger finger, Disability of Arm-Shoulder-Hand (DASH) score, pain-visual analogue scale (VAS), grip strength, whether they gained a full range of motion (ROM), and complications before and after surgery. Results: Finally, 29 and 28 patients were included in the control and rehabilitation groups, respectively. At final follow-up, the DASH score, grip strength, and ROM were significantly improved in the rehabilitation group compared to that preoperatively. At final follow-up, pain was significantly improved in both groups from that preoperatively. There were no significant differences in the results, including the DASH score, grip strength, ROM and pain-VAS between the control and rehabilitation groups at the final follow-up. Subgroup analysis showed that there is a significant difference in the DASH score of patients doing housework or light work and those with a duration of symptoms &gt;12 months between the control and rehabilitation groups at the final follow-up.

    DOI: 10.3390/jcm12227187

    researchmap

  • Factors associated with survival in patients with clear cell sarcoma. 国際誌

    Tomohiro Fujiwara, Toshiyuki Kunisada, Eiji Nakata, Toshiharu Mitsuhashi, Toshifumi Ozaki, Akira Kawai

    The bone & joint journal   105-B ( 11 )   1216 - 1225   2023年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Clear cell sarcoma (CCS) of soft-tissue is a rare melanocytic subtype of mesenchymal malignancy. The aim of this study was to investigate the clinical and therapeutic factors associated with increased survival, stratified by clinical stage, in order to determine the optimal treatment. METHODS: The study was a retrospective analysis involving 117 patients with histologically confirmed CCS, between July 2016 and November 2017, who were enrolled in the Bone and Soft Tissue Tumour Registry in Japan. RESULTS: The five- and ten-year survival rates were 41% (95% confidence interval (CI) 29 to 52) and 37% (95% CI 25 to 49), respectively. On multivariable analysis, the size of the tumour of > 10 cm (p = 0.006), lymph node metastasis at the time of diagnosis (p < 0.001), distant metastases at the time of diagnosis (p < 0.001), and no surgery for the primary tumour (p = 0.019) were independently associated with a poor survival. For N0M0 CCS (n = 68), the development of distant metastases was an independent prognostic factor for survival (early (< 12 months), hazard ratio (HR) 116.78 (95% CI 11.69 to 1,166.50); p < 0.001; late (> 12 months), HR 14.79 (95% CI 1.66 to 131.63); p = 0.016); neoadjuvant/adjuvant chemotherapy (p = 0.895) and/or radiotherapy (p = 0.216) were not significantly associated with survival. The five-year cumulative incidence of local recurrence was 19% (95% CI 8 to 35) and the size of the tumour was significantly associated with an increased rate of local recurrence (p = 0.012). For N1M0 CCS (n = 18), the risk of mortality was significantly lower in patients who underwent surgery for both the primary tumour and lymph node metastases (HR 0.03 (95% CI 0.00 to 0.56); p = 0.020). For M1 CCS (n = 31), excision of the primary tumour was independently associated with better survival (HR 0.26 (95% CI 0.09 to 0.76); p = 0.013). There was no significant difference in survival between the different types of systemic treatment (p = 0.523). CONCLUSION: Complete excision of the primary tumour and lymph nodes is associated with a better survival in patients with CCS. Systemic treatment appears to provide limited benefits, demonstrating a pressing need for novel systemic agents.

    DOI: 10.1302/0301-620X.105B11.BJJ-2022-0743.R3

    PubMed

    researchmap

  • みんなで行う骨転移診療-診療均てん化を目指した整形外科キャリアステージ別スキルの再確認- 骨転移診療のスキル 外傷整形外科医編

    野田 知之, 阿部 信寛, 尾崎 敏文, 中田 英二, 依光 正則, 上原 健敬

    日本整形外科学会雑誌   97 ( 11 )   993 - 997   2023年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 思春期特発性側彎症に対する脊椎後方固定術において術中低体温は入院期間を延長させる

    篠原 健介, 三澤 治夫, 魚谷 弘二, 小田 孔明, 鉄永 倫子, 志渡澤 央和, 植田 昌敬, 鷹取 亮, 尾崎 敏文

    西日本脊椎研究会抄録集   98回   21 - 21   2023年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:西日本脊椎研究会  

    researchmap

  • Associations among Preoperative Malnutrition, Muscle Loss, and Postoperative Walking Ability in Intertrochanteric Fractures: A Retrospective Study.

    Kohei Sato, Hironori Tsuji, Masanori Yorimitsu, Takenori Uehara, Yuki Okazaki, Shinichiro Takao, Toshiaki Hata, Shiro Fukuoka, Tomoyuki Noda, Hideyuki Kanda, Toshifumi Ozaki

    Acta medica Okayama   77 ( 5 )   511 - 516   2023年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Sarcopenia and malnutrition are increasing in older adults and are reported risk factors for functional impairment after hip fracture surgery. This study aimed to investigate the associations between skeletal muscle mass loss, malnutrition, and postoperative walking ability in patients with hip fracture. We retrospectively reviewed patients who underwent intertrochanteric fracture surgery at our institute. The psoas muscle index, controlling nutritional status score, and functional ambulation category (FAC) were used to evaluate skeletal muscle mass, nutritional status, and walking ability, respectively. Six months after surgery, walking ability was assessed as either "gait disturbance" or "independent gait". Multivariate binomial logistic regression analysis, with skeletal muscle mass, nutritional status, and other factors, was used to predict the risk of being assigned to the gait disturbance group. This study included 95 patients (mean age, 85.2 years; 70 women). Sixty-six patients had low skeletal muscle mass, 35 suffered from malnutrition, and 28 had both. Malnutrition and low skeletal muscle mass were significantly associated with postoperative gait disturbance (FAC < 3). Preoperative low skeletal muscle mass and malnutrition were risk factors for postoperative poor walking ability. Further preventive interventions focusing on skeletal muscle mass and nutritional status are required.

    DOI: 10.18926/AMO/65973

    PubMed

    researchmap

  • Time-Dependent Increase in Medial Meniscus Extrusion Predicts the Need for Meniscal Repair in Patients with Partial Medial Meniscus Posterior Root Tears: A Case-Control Study. 国際誌

    Koki Kawada, Takayuki Furumatsu, Masanori Tamura, Haowei Xue, Naohiro Higashihara, Keisuke Kintaka, Yusuke Yokoyama, Toshifumi Ozaki

    Indian journal of orthopaedics   57 ( 10 )   1633 - 1639   2023年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: This study aimed to compare medial meniscus extrusion (MME) in patients with partial medial meniscus posterior root tears (MMPRTs) through magnetic resonance imaging (MRI) conducted at two-time points and to determine whether patient characteristics or MME measurements differ in patients who respond to nonoperative treatment compared with those who require surgical treatment. METHODS: Thirty-seven patients with partial MMPRTs underwent two MRI scans during nonoperative management or before pull-out repair. Among these, 17 patients received nonoperative management, and 20 underwent pull-out repair. Partial MMPRTs were diagnosed based on the MRI findings. MME measurements were performed on both MRI scans. Statistical and receiver operating curve (ROC) analyses were performed. RESULTS: The duration between the two MRI scans was significantly shorter in the pull-out repair group than in the nonoperative management group. The increase in MME (ΔMME) on MRI scans was significantly greater in the pull-out repair group than in the nonoperative management group. Linear regression analysis revealed a weak correlation between the MRI interval and ΔMME in the nonoperative management group and a moderate correlation in the pull-out repair group. In the ROC construction, the cut-off value for ΔMME that requires surgical intervention was 0.41 mm, with a sensitivity and specificity of 85.0% and 52.9%, respectively. CONCLUSION: Patients with partial MMPRTs requiring surgical treatment had greater MME progression in a shorter time and a time-dependent increase in MME. Therefore, a ΔMME of ≥ 0.41 mm may be useful in deciding surgical intervention based on MRI retests. LEVEL OF EVIDENCE: III.

    DOI: 10.1007/s43465-023-00987-3

    PubMed

    researchmap

  • Medial joint space narrowing progresses after pullout repair of medial meniscus posterior root tear. 国際誌

    Koki Kawada, Takayuki Furumatsu, Masanori Tamura, Haowei Xue, Naohiro Higashihara, Keisuke Kintaka, Yusuke Yokoyama, Toshifumi Ozaki

    International orthopaedics   47 ( 10 )   2401 - 2407   2023年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The extent to which arthropathic changes progress after medial meniscus posterior root tear (MMPRT) repair remains controversial. This retrospective study assessed medial joint space (MJS) narrowing progression after pullout repair for MMPRT and identified the correlating factors. METHODS: We included 56 patients who underwent pullout repair for MMPRT. The MJS of the bilateral knees was assessed with radiography using the fixed-flexion view. A second-look arthroscopy was performed one year post-operatively for all patients. The baseline characteristics, clinical scores, Kellgren-Lawrence (KL) grade, and medial meniscus extrusion (MME) were identified. Statistical comparisons and correlation analyses were conducted. RESULTS: The MJS narrowing width was significantly larger in MMPRT knees than in contralateral knees (0.51 ± 0.85 mm vs. 0.09 ± 0.49 mm, p < 0.001). KL grade progression was observed in 23.2% (13/56) of patients. There was a significant difference between pre- and post-operative MME values, indicating MME progression (p < 0.001). Each clinical score showed significant improvement one year post-operatively (p < 0.001). Positive correlations were found between MJS narrowing and pre-operative MJS (coefficient = 0.510, p < 0.001), rate of change in MJS (coefficient = 0.929, p < 0.001), and increase in MME (ΔMME) (coefficient = 0.506, p < 0.001). CONCLUSION: Knees that underwent pullout repair for MMPRT showed progression of MJS narrowing by 0.51 mm at one year post-operatively, although clinical scores markedly improved. Correlating factors for MJS narrowing were pre-operative MJS, rate of change in MJS, and ΔMME. Preventing MME progression is essential for preventing arthropathic changes.

    DOI: 10.1007/s00264-023-05701-4

    PubMed

    researchmap

  • Concomitant posterior anchoring further reduces posterior meniscal extrusion during pullout repair of medial meniscus posterior root tears: a retrospective study. 国際誌

    Haowei Xue, Takayuki Furumatsu, Takaaki Hiranaka, Keisuke Kintaka, Naohiro Higashihara, Masanori Tamura, Ximing Zhang, Toshifumi Ozaki

    International orthopaedics   47 ( 10 )   2391 - 2400   2023年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Transtibial pullout repair improves the clinical outcomes of medial meniscus (MM) posterior root tears (PRTs); however, reducing MM extrusion remains challenging. Thus, the purpose of this study was to examine the role of additional posterior anchoring (PA) during pullout repair in reducing the severity of MM extrusion compared to pullout repair alone. METHODS: Patients who underwent pullout repair with two-cinch stitches (TCS) only or TCS combined with PA (TCS-PA)-deployment of an additional suture anchor in the posteromedial corner of MM-were included retrospectively. MM medial and posterior extrusion (MMME and MMPE), MM extrusion and remaining volume (MMEV and MMRV), and corresponding ratios were evaluated pre-operatively and three months post-operatively using a three-dimensional meniscal model at 10° and 90° of knee flexion and compared within and between groups. RESULTS: A total of 15 and 16 patients treated with TCS and TCS-PA, respectively, were enrolled. At 90° knee flexion, both techniques significantly reduced MMPE (TCS: 4.2 ± 0.7 mm to 3.5 ± 0.6 mm, p < 0.05; TCS-PA: 3.7 ± 0.8 mm to 2.8 ± 0.7 mm, p < 0.05) at three months post-operatively. TCS-PA reduced MMPE more significantly than TCS alone (p < 0.05). Only TCS-PA significantly improved the MMEV and MMRV ratios (39.6 ± 8.9% to 28.1 ± 6.0%, p < 0.05 and 60.4 ± 8.9% to 71.9 ± 6.0%, p < 0.05, respectively). Significance was not found in all other comparisons. CONCLUSIONS: Both techniques improved MMPE at knee flexion at the three month follow-up, with TCS-PA providing significantly superior results. Our findings support the evidence that the application of PA may be an effective surgical option for alleviating persistent MMPE.

    DOI: 10.1007/s00264-022-05660-2

    PubMed

    researchmap

  • Epidemiological features of acute medial meniscus posterior root tears. 国際誌

    Yusuke Kamatsuki, Takayuki Furumatsu, Takaaki Hiranaka, Yuki Okazaki, Keisuke Kintaka, Yuya Kodama, Shinichi Miyazawa, Toshifumi Ozaki

    International orthopaedics   47 ( 10 )   2537 - 2545   2023年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Untreated or overlooked medial meniscus posterior root tears (MMPRTs) induce sequential knee joint degradation. We evaluated epidemiological features of acute MMPRT for its early detection and accurate diagnosis. METHODS: Among 330 MMPRT patients from 2018 to 2020, those who underwent arthroscopic pullout repairs were enrolled. Patients who underwent non-operative treatment or knee arthroplasty, those with a cruciate ligament-deficient knee or advanced osteoarthritis of the knee, and those with insufficient data were excluded. Finally, we retrospectively evaluated data from 234 MMPRTs (female: 79.9%, complete tears: 92.7%, mean age: 65 years). Welch's t-test and Chi-squared test were used for pairwise comparisons. Spearman's rank correlation analysis was performed between age at surgery and body mass index (BMI). Multivariable logistic regression analysis with stepwise backward elimination was applied to the values as risk factors for painful popping events. RESULTS: In both sexes, there were significant differences in height, weight, and BMI. In all patients, there was a significant negative correlation between BMI and age (ρ =  - 0.36, p < 0.001). The BMI cutoff value of 27.7 kg/m2 had a 79.2% sensitivity and a 76.9% specificity for detecting MMPRT patients aged < 50 years. A painful popping event was confirmed in 187 knees (79.9%), and the frequency was significantly reduced in partial tears as compared to complete tears (odds ratio: 0.080, p < 0.001). CONCLUSION: Higher BMI was associated with a significantly younger age of MMPRT onset. Partial MMPRTs had a low frequency of painful popping events (43.8%).

    DOI: 10.1007/s00264-023-05848-0

    PubMed

    researchmap

  • 【整形外科外来Red Flags 2023】脊椎転移におけるRed Flags

    中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文

    Orthopaedics   36 ( 10 )   69 - 80   2023年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(株)全日本病院出版会  

    椎体転移では腫瘍が増大すると腫瘍が直接神経を圧迫したり,椎体圧潰により脊髄が圧迫され,知覚障害や運動麻痺が生じることがある.ほとんどの骨転移患者は,麻痺が発生する前に脊椎転移部に痛みを自覚している.したがって,痛みは麻痺の危険信号であり,脊椎転移部に痛みが出現した場合,早急に治療を開始することが重要である.麻痺を予防するために,最も基本的で重要な対処法は,脊椎転移部に痛みが出現した場合,脊椎SREsの発生も考え,早急に画像検査を行い,痛みの原因と考えられる著しい椎体破壊や脊髄圧迫を認めた場合,早急に治療(RTなど)を行うことである(Red Flag).なお,早急に画像検査が行えない場合,直近のCT等を見直し,椎体破壊の有無を確認すべきである.Red Flagに対して早急に対処し,麻痺が出現する前に治療が開始できれば,麻痺発生数を減らすことができる.(著者抄録)

    researchmap

  • Increased quadriceps muscle strength after medial meniscus posterior root repair is associated with decreased medial meniscus extrusion progression. 国際誌

    Koki Kawada, Takayuki Furumatsu, Mikao Fukuba, Masanori Tamura, Naohiro Higashihara, Yuki Okazaki, Yusuke Yokoyama, Yoshimi Katayama, Masanori Hamada, Toshifumi Ozaki

    BMC musculoskeletal disorders   24 ( 1 )   727 - 727   2023年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: This study aimed to assess quadriceps muscle strength after medial meniscus (MM) posterior root repair and determine its relationship with clinical scores and MM extrusion (MME). METHODS: Thirty patients who underwent pullout repair for MM posterior root tear and were evaluated for quadriceps muscle strength preoperatively and at 1 year postoperatively were included in this study. Quadriceps muscle strength was measured using the Locomo Scan-II instrument (ALCARE, Tokyo, Japan). MME and clinical scores (i.e., Knee Injury and Osteoarthritis Outcome Score [KOOS], International Knee Documentation Committee score, Lysholm score, Tegner score, and visual analog scale pain score) were evaluated preoperatively and at 1 year postoperatively, and second-look arthroscopy was performed at 1 year postoperatively. Wilcoxon's signed-rank test was used to compare each measure pre- and postoperatively. Pearson's correlation coefficient was used to assess the correlation with quadriceps muscle strength values. Multiple regression analysis was performed to identify factors associated with the change in MME (ΔMME). RESULTS: Second-look arthroscopy confirmed continuity of the posterior root in all patients. The quadriceps muscle strength measured at 1 year postoperatively (355.1 ± 116.2 N) indicated significant improvement relative to the quadriceps muscle strength measured preoperatively (271.9 ± 97.4 N, p < 0.001). The MME at 1 year postoperatively (4.59 ± 1.24 mm) had progressed significantly relative to the MME preoperatively (3.63 ± 1.01 mm, p < 0.001). The clinical scores at 1 year postoperatively were improved significantly relative to the scores preoperatively (p < 0.001). The postoperative quadriceps muscle strength was correlated with ΔMME (correlation coefficient = -0.398, p = 0.030), and the change in quadriceps muscle strength was correlated with the KOOS-Quality of Life (correlation coefficient = 0.430, p = 0.018). Multiple regression analysis showed that the postoperative quadriceps muscle strength had a significant effect on ΔMME even when the body mass index and time from injury to surgery were included. CONCLUSIONS: After MM posterior root repair, patients with greater quadriceps muscle strength showed less MME progression. In addition, patients with greater improvement in quadriceps muscle strength had better clinical scores; therefore, continued rehabilitation aimed at improving quadriceps muscle strength after MM posterior root repair is recommended. LEVEL OF EVIDENCE: IV.

    DOI: 10.1186/s12891-023-06858-0

    PubMed

    researchmap

  • 完全Web化された医工連携の試み 関節可動域自動計測システムの開発

    速川 湧気, 吉岡 健太郎, 鈴木 諒, 中原 龍一, 那須 義久, 西田 圭一郎, 尾崎 敏文

    中国・四国整形外科学会雑誌   35 ( 2 )   225 - 230   2023年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 深層学習と民生用3Dセンサを用いた低コスト高精度肘関節可動域自動計測システムの試み

    鈴木 諒, 吉岡 健太郎, 速川 湧気, 中原 龍一, 那須 義久, 西田 圭一郎, 尾崎 敏文

    中国・四国整形外科学会雑誌   35 ( 2 )   219 - 224   2023年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 大腿骨頸部骨折を合併した寛骨臼両柱骨折の1例

    福岡 史朗, 佐藤 浩平, 畑 利彰, 尾崎 敏文, 依光 正則, 上原 健敬

    中国・四国整形外科学会雑誌   35 ( 2 )   285 - 288   2023年9月

  • Advances in treatment of alveolar soft part sarcoma: an updated review. 国際誌

    Tomohiro Fujiwara, Toshiyuki Kunisada, Eiji Nakata, Kenji Nishida, Hiroyuki Yanai, Tomoki Nakamura, Kazuhiro Tanaka, Toshifumi Ozaki

    Japanese journal of clinical oncology   2023年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Alveolar soft part sarcoma is a rare neoplasm of uncertain histogenesis that belongs to a newly defined category of ultra-rare sarcomas. The neoplasm is characterized by a specific chromosomal translocation, der (17) t(X; 17)(p11.2;q25), that results in ASPSCR1-TFE3 gene fusion. The natural history of alveolar soft part sarcoma describes indolent behaviour with slow progression in deep soft tissues of the extremities, trunk and head/neck in adolescents and young adults. A high rate of detection of distant metastasis at presentation has been reported, and the most common metastatic sites in decreasing order of frequency are the lung, bone and brain. Complete surgical resection remains the standard treatment strategy, whereas radiotherapy is indicated for patients with inadequate surgical margins or unresectable tumours. Although alveolar soft part sarcoma is refractory to conventional doxorubicin-based chemotherapy, monotherapy or combination therapy using tyrosine kinase inhibitors and immune checkpoint inhibitors have provided antitumor activity and emerged as new treatment strategies. This article provides an overview of the current understanding of this ultra-rare sarcoma and recent advancements in treatments according to the clinical stage of alveolar soft part sarcoma.

    DOI: 10.1093/jjco/hyad102

    PubMed

    researchmap

  • Wrist arthrodesis combined with a bulk bone allograft for implant loosening after total wrist arthroplasty: a case report. 国際誌

    Yoshihisa Nasu, Keiichiro Nishida, Masamitsu Natsumeda, Ryuichi Nakahara, Ryozo Harada, Toshifumi Ozaki

    Modern rheumatology case reports   2023年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Total wrist arthroplasty is a challenging procedure for wrist joints severely destroyed by rheumatoid arthritis. The most common postoperative complication of total wrist arthroplasty is the loosening of the carpal component. Revision surgeries for failed total wrist arthroplasties can be complicated owing to severe bone loss and concomitant soft-tissue problems. Here we report a case (68-year-old woman with a history of rheumatoid arthritis for 24 years) of severe aseptic loosening of semi-constrained total wrist arthroplasty and its salvage surgery. During the primary arthroplasty procedure, severe instability at the second through fifth carpometacarpal joints was observed, and arthrodesis of these joints was required. The radiographs obtained nine months after surgery showed loosening of the carpal component. Subsequently, she suffered a stroke, resulting in a loss of follow-up, and higher stress was loaded on her upper extremities during standing and walking. In the radiograph taken at her revisit 25 months after the primary surgery, the subsidence of the carpal component progressed, and loosening of the radial component was observed. Total wrist arthrodesis was performed using a bulk bone allograft of the femoral head, combined with a penetrating Wrist Fusion Rod®. Rapid bone union was achieved without soft tissue irritation. We conclude that wrist arthrodesis with a bulk bone allograft combined with an intramedullary nail is a reasonable option for failed total wrist arthroplasty.

    DOI: 10.1093/mrcr/rxad048

    PubMed

    researchmap

  • 内側半月板後根修復術後の早期部分荷重は半月板修復状態を悪化させない

    田村 優典, 古松 毅之, 横山 裕介, 金高 圭甫, 東原 直裕, 川田 紘己, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 8 )   S1643 - S1643   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • ヒトiPS細胞由来肢芽間葉系細胞の発生機序の検討

    高尾 知佳, 大曽根 達則, 山田 大祐, 中田 英二, 尾崎 敏文, 宝田 剛志

    日本整形外科学会雑誌   97 ( 8 )   S1599 - S1599   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • テロメラーゼ依存性腫瘍融解アデノウイルスの骨・軟部腫瘍への応用を目指した蛍光タンパクによるウイルスの治療効果予測

    魚谷 弘二, 藤原 智洋, 田澤 大, 植田 昌敬, 志渡澤 央和, 小田 孔明, 鉄永 倫子, 三澤 治夫, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 8 )   S1714 - S1714   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 軟部組織再建への応用を目指した脱細胞化骨格筋の作製法の確立

    福岡 史朗, 藤原 智洋, 澤田 和也, 依光 正則, 上原 健敬, 尾崎 敏文, 藤里 俊哉

    日本整形外科学会雑誌   97 ( 8 )   S1900 - S1900   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫診療におけるがん遺伝子パネルの有用性

    中田 英二, 藤原 智洋, 国定 俊之, 遠西 大輔, 山本 英喜, 二宮 貴一朗, 冨田 秀太, 二川 摩周, 平沢 晃, 豊岡 伸一, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 8 )   S1894 - S1894   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫に対する微小環境改善薬の開発 ナノキャリア修飾によるCSF-1/CSF-1R阻害剤の安全性の向上

    藤原 智洋, Yakoub Mohamed, 吉田 晶, 近藤 彩奈, 板野 拓人, 片山 晴喜, 中田 英二, 国定 俊之, 尾崎 敏文, Ouerfelli Ouerthek, Healey John

    日本整形外科学会雑誌   97 ( 8 )   S1892 - S1892   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Computer assisted orthopaedic surgeryがもたらす整形外科の次世代診療 希少疾患に対するAI開発戦略

    長谷井 嬢, 中原 龍一, 藤原 智洋, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 8 )   S1783 - S1783   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 血中CSF-1濃度は浸潤性軟部肉腫における腫瘍随伴マクロファージの浸潤と相関し生存予後と相関する

    畑 利彰, 藤原 智洋, 吉田 晶, 近藤 彩奈, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 8 )   S1886 - S1886   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫細胞と肉腫微小環境の双方を標的とする複合治療の開発 軟部肉腫に対する新しい治療アプローチ

    近藤 彩奈, 藤原 智洋, 吉田 晶, 畑 利彰, 板野 拓人, 片山 晴喜, 佐藤 浩平, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 8 )   S1885 - S1885   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • MPNST腫瘍細胞内のカテコラミン合成経路の阻害ががん幹細胞性に与える影響と治療薬としての可能性

    片山 晴喜, 藤村 篤史, 中田 英二, 板野 拓人, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 8 )   S1884 - S1884   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 翻訳制御機構を標的とした横紋筋肉腫の新規治療法の開発

    板野 拓人, 中田 英二, 藤村 篤史, 黄 栄生, 片山 晴喜, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 8 )   S1884 - S1884   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • ヒトiPS細胞由来肢芽間葉系細胞を用いた骨再建法の開発

    佐藤 浩平, 高尾 知佳, 中田 英二, 藤澤 佑樹, 山田 大祐, 上原 健敬, 藤原 智洋, 依光 正則, 国定 俊之, 尾崎 敏文, 宝田 剛志

    日本整形外科学会雑誌   97 ( 8 )   S1868 - S1868   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Index of postural stability(IPS)を用いた思春期特発性側彎症患者における動的姿勢制御能力の検討

    小田 孔明, 三澤 治夫, 鉄永 倫子, 魚谷 弘二, 志渡澤 央和, 植田 昌敬, 山脇 諒子, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 8 )   S1839 - S1839   2023年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • LRRC15 expression indicates high level of stemness regulated by TWIST1 in mesenchymal stem cells. 国際誌

    Kensuke Toriumi, Yuta Onodera, Toshiyuki Takehara, Tatsufumi Mori, Joe Hasei, Kanae Shigi, Natsumi Iwawaki, Toshifumi Ozaki, Masao Akagi, Mahito Nakanishi, Takeshi Teramura

    iScience   26 ( 7 )   106946 - 106946   2023年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Mesenchymal stem cells (MSCs) are used as a major source for cell therapy, and its application is expanding in various diseases. On the other hand, reliable method to evaluate quality and therapeutic properties of MSC is limited. In this study, we focused on TWIST1 that is a transcription factor regulating stemness of MSCs and found that the transmembrane protein LRRC15 tightly correlated with the expression of TWIST1 and useful to expect TWIST1-regulated stemness of MSCs. The LRRC15-positive MSC populations in human and mouse bone marrow tissues highly expressed stemness-associated transcription factors and therapeutic cytokines, and showed better therapeutic effect in bleomycin-induced pulmonary fibrosis model mice. This study provides evidence for the important role of TWIST1 in the MSC stemness, and for the utility of the LRRC15 protein as a marker to estimate stem cell quality in MSCs before cell transplantation.

    DOI: 10.1016/j.isci.2023.106946

    PubMed

    researchmap

  • Influence of Janus kinase inhibitors on early postoperative complications in patients with rheumatoid arthritis undergoing orthopaedic surgeries. 国際誌

    Keiichiro Nishida, Ryozo Harada, Yoshihisa Nasu, Shuichi Naniwa, Ryuichi Nakahara, Yoshifumi Hotta, Noriyuki Shimizu, Deting Lin, Toshifumi Ozaki

    Modern rheumatology   2023年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: We retrospectively reviewed the records of rheumatoid arthritis (RA) patients who underwent orthopaedic surgery to examine the influence of the perioperative use of Janus kinase (JAK) inhibitors on early postoperative complications. PATIENTS AND METHODS: Thirty-two patients with RA under disease control with JAK inhibitors who underwent 49 orthopaedic procedures were included in the study. Patient records after surgery were investigated for surgical site infection (SSI), delayed wound healing (DWH), flare-up of the disease, pre-and postoperative absolute lymphocyte counts (ALCs), venous thromboembolism and other postoperative complications. RESULTS: JAK inhibitors were continued during the perioperative period in 31 procedures. In the remaining 18 procedures, JAK inhibitors were discontinued perioperatively with a mean discontinuation period of 2.4 days. No instances of SSI were identified in any patient during at least 90 days' follow-up, while DWH was seen in one patient. Disease flare-up was noted in two patients after 3 and 9 days of discontinuation of JAK inhibitors, respectively. The ALCs significantly decreased on postoperative Day 1 (P < 0.0001) and there was a significant correlation between pre- and post-one day ALCs (r = 0.75, P < 0.0001). CONCLUSION: JAK inhibitors seem to be safe during the perioperative period of orthopaedic surgery.

    DOI: 10.1093/mr/road047

    PubMed

    researchmap

  • 悪性末梢神経鞘腫瘍における治療標的PRRX1の同定と新規創薬開発の可能性

    たき平 将太, 山田 大祐, 岡本 真幸, 高尾 知佳, 中田 英二, 板野 拓人, 藤原 智洋, 国定 俊之, 尾崎 敏文, 宝田 剛志

    日本整形外科学会雑誌   97 ( 6 )   S1428 - S1428   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 腫瘍 軟部腫瘍に対する放射線治療後の病的大腿骨骨折術後感染に対する治療戦略

    斎藤 太一, 上原 健敬, 中道 亮, 依光 正則, 島村 安則, 野田 知之, 尾崎 敏文

    日本骨・関節感染症学会プログラム・抄録集   46回   82 - 82   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨・関節感染症学会  

    researchmap

  • 非転位型の橈骨遠位端骨折において骨折部位,Lister結節形状は長母指伸筋腱断裂に影響する

    斎藤 太一, 近藤 秀則, 福岡 史朗, 佐藤 浩平, 畑 利彰, 中道 亮, 依光 正則, 島村 安則, 尾崎 敏文

    骨折   45 ( Suppl. )   S301 - S301   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 術前化学療法を併用した四肢高悪性度肉腫に対する局所再発の臨床病理学的背景 JCOG0304副次的解析

    筑紫 聡, 田仲 和宏, 国定 俊之, 町田 龍之介, 竹中 聡, 川井 章, 片桐 浩久, 比留間 徹, 松本 嘉寛, 土屋 弘行, 中山 ロバート, 畠野 宏史, 江森 誠人, 吉田 新一郎, 大幸 英至, 坂本 昭夫, 今西 淳悟, 喜多 亮介, 尾崎 敏文, 岩本 幸英

    日本整形外科学会雑誌   97 ( 6 )   S1459 - S1459   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • The clinical and radiographic outcomes of type 2 medial meniscus posterior root tears following transtibial pullout repair. 国際誌

    Takaaki Hiranaka, Takayuki Furumatsu, Yusuke Yokoyama, Keisuke Kintaka, Naohiro Higashihara, Masanori Tamura, Koki Kawada, Haowei Xue, Masanori Hamada, Toshifumi Ozaki

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA   31 ( 6 )   2323 - 2330   2023年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The aim of this study was to compare the clinical outcomes of different subtypes of type 2 medial meniscus posterior root tears following transtibial pullout repair. METHODS: In total, 147 patients (mean age: 66.2 ± 8.3 years) who were diagnosed with type 2 medial meniscus posterior root tears and underwent transtibial pullout repair were included. Patients were divided into 2A (n = 31), 2B (n = 90), and 2C (n = 26) groups according to tear type. Clinical outcomes were assessed pre-operatively and at second-look arthroscopy using the Knee injury and Osteoarthritis Outcome Score. The meniscal healing status was evaluated at second-look arthroscopy. Medial meniscus extrusion was calculated using magnetic resonance imaging pre-operatively and at second-look arthroscopy. RESULTS: No significant differences in pre-operative or post-operative clinical scores were observed between each subtype, although clinical scores improved post-operatively for each subtype. Significant differences were noted in the anteroposterior width of the bridging tissues at second-look arthroscopy (2A, 7.1 ± 1.2; 2B, 6.2 ± 1.7; and 2C, 6.2 ± 1.7 mm; p = 0.045); type 2A tears were the widest. There was a significant difference in post-operative medial meniscus extrusion (2A, 3.2 ± 0.9; 2B, 4.0 ± 1.2; and 2C, 4.0 ± 1.4 mm; p = 0.004) and its progression (2A, 0.7 ± 0.6; 2B, 1.2 ± 0.8; and 2C, 1.2 ± 0.8 mm; p = 0.008), and type 2A tears were the shortest. CONCLUSION: Although there was no significant difference in the post-operative clinical scores among different type 2 tears in the short term, type 2A tears showed better healing and medial meniscus extrusion progression prevention, thus indicating the usefulness of classifying tear type in estimating post-operative outcomes. LEVEL OF EVIDENCE: III.

    DOI: 10.1007/s00167-022-07293-9

    PubMed

    researchmap

  • 関節リウマチ患者に対する前足部切除関節形成術後の骨棘切除術

    志水 紀之, 浪花 崇一, 堀田 佳史, 中原 龍一, 那須 義久, 西田 圭一郎, 尾崎 敏文

    日本関節病学会誌   42 ( 3 )   249 - 249   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本関節病学会  

    researchmap

  • 両手関節炎様の所見を呈した腱黄色腫の1例

    浪花 崇一, 志水 紀之, 林 徳てい, 堀田 佳史, 中原 龍一, 那須 義久, 尾崎 敏文, 西田 圭一郎

    日本関節病学会誌   42 ( 3 )   214 - 214   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本関節病学会  

    researchmap

  • 大規模言語モデル(ChatGPT)による医師国家試験解答解析

    中原 龍一, 西田 圭一郎, 高橋 康, 那須 義久, 堀田 佳史, 浪花 崇一, 志水 紀之, 尾崎 敏文

    日本関節病学会誌   42 ( 3 )   191 - 191   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本関節病学会  

    researchmap

  • J-SC人工肘関節の連結部に破損を生じた1例

    那須 義久, 西田 圭一郎, 志水 紀之, 浪花 崇一, 堀田 佳史, 中原 龍一, 尾崎 敏文

    日本関節病学会誌   42 ( 3 )   270 - 270   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本関節病学会  

    researchmap

  • 切除不能な骨巨細胞腫に対するデノスマブのde-escalation

    片山 晴喜, 中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1347 - S1347   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨転移とどう向き合うか 骨転移診療システムにおける脊椎転移の保存的治療とリハビリテーション診療

    杉原 進介, 近藤 宏也, 中田 英二, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1422 - S1422   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • MPNST腫瘍細胞内のカテコラミン合成経路とその腫瘍幹細胞性維持に対する役割

    片山 晴喜, 藤村 篤史, 中田 英二, 板野 拓人, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1493 - S1493   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 手術予定がん患者のロコモティブシンドロームと関連因子

    堅山 佳美, 中田 英二, 濱田 全紀, 国定 俊之, 藤原 智洋, 近藤 彩奈, 千田 益生, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1477 - S1477   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 軟部肉腫患者における地理的因子の臨床的意義 肉腫専門施設受診前因子の改善を目指して

    畑 利彰, 藤原 智洋, 国定 俊之, 中田 英二, 近藤 宏也, 佐藤 浩平, 近藤 彩奈, 片山 晴喜, 板野 拓人, 吉田 晶, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1467 - S1467   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨・軟部腫瘍の教育と専門医育成 骨・軟部腫瘍における基礎・トランスレーショナル研究の魅力

    藤原 智洋, 中田 英二, 国定 俊之, 川井 章, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1302 - S1302   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 周術期がん患者におけるがんロコモティブシンドローム

    尾崎 敏文, 堅山 佳美, 濱田 全紀, 国定 俊之, 藤原 智洋, 千田 益生, 中田 英二

    運動器リハビリテーション   34 ( 2 )   155 - 155   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本運動器科学会  

    researchmap

  • 高齢軟部肉腫患者において年代別で生存予後因子および合併症リスク因子は異なるか

    近藤 彩奈, 藤原 智洋, 畑 利彰, 板野 拓人, 片山 晴喜, 佐藤 浩平, 吉田 晶, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1465 - S1465   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫診療におけるゲノム医療

    板野 拓人, 中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1449 - S1449   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨盤悪性骨腫瘍に対する股関節包内切除術と包外切除術の腫瘍学的予後および機能的予後の比較検討

    藤原 智洋, Stevenson Jonathan, Parry Michael, Grimer Robert, 津田 祐輔, 長谷井 嬢, 中田 英二, 国定 俊之, 尾崎 敏文, Jeys Lee

    日本整形外科学会雑誌   97 ( 6 )   S1443 - S1443   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 小児骨・軟部腫瘍の治療:進歩と課題 小児悪性骨腫瘍の再建の工夫と問題点

    国定 俊之, 中田 英二, 藤原 智洋, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1424 - S1424   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 前腕の軟部肉腫の治療成績

    中田 英二, 国定 俊之, 藤原 智洋, 片山 晴喜, 板野 拓人, 近藤 彩奈, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 6 )   S1380 - S1380   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 外傷性足関節症に至った脛骨ピロン骨折の一例

    上原 健敬, 志水 紀之, 浪花 崇一, 福岡 史朗, 依光 正則, 尾崎 敏文

    骨折   45 ( Suppl. )   S188 - S188   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 踵骨骨折に対するBest Practice 2023 in Japan Sinus tarsi approachの実際と固定法

    依光 正則, 佐藤 浩平, 福岡 史朗, 上原 健敬, 尾崎 敏文

    骨折   45 ( Suppl. )   S167 - S167   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 脛骨プラトー骨折における後外側骨片アプローチと固定の是非

    依光 正則, 福岡 史朗, 上原 健敬, 尾崎 敏文

    骨折   45 ( Suppl. )   S127 - S127   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 腫瘍 軟部腫瘍に対する放射線治療後の病的大腿骨骨折術後感染に対する治療戦略

    斎藤 太一, 上原 健敬, 中道 亮, 依光 正則, 島村 安則, 野田 知之, 尾崎 敏文

    日本骨・関節感染症学会プログラム・抄録集   46回   82 - 82   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨・関節感染症学会  

    researchmap

  • 脛骨々幹部骨折に対する異なるアプローチ間での髄内釘の挿入位置の検討

    福岡 史朗, 依光 正則, 上原 健敬, 寺田 忠司, 尾崎 敏文

    骨折   45 ( Suppl. )   S356 - S356   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 3DCTを用いた載距突起への至適なscrew設置の解剖学的ランドマークの検討

    福岡 史朗, 依光 正則, 上原 健敬, 尾崎 敏文

    骨折   45 ( Suppl. )   S264 - S264   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 当科における下肢長管骨偽関節の治療成績

    上原 健敬, 福岡 史朗, 佐藤 浩平, 畑 利彰, 依光 正則, 野田 知之, 尾崎 敏文

    骨折   45 ( Suppl. )   S242 - S242   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • Floating Hip術後に対してTHAを行い感染した1例

    福岡 史朗, 依光 正則, 上原 健敬, 鉄永 智紀, 尾崎 敏文

    日本骨・関節感染症学会プログラム・抄録集   46回   186 - 186   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨・関節感染症学会  

    researchmap

  • 踵骨開放骨折術後の深部感染に対しCLAP療法を行った1例

    志水 紀之, 依光 正則, 福岡 史朗, 上原 健敬, 尾崎 敏文

    日本骨・関節感染症学会プログラム・抄録集   46回   125 - 125   2023年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨・関節感染症学会  

    researchmap

  • 軟部肉腫に対する広範切除後の機能回復は成人患者と高齢患者でどのように異なるか? 下肢発生肉腫の検討

    藤原 智洋, 中田 英二, 近藤 彩奈, 堅山 佳美, 濱田 全紀, 国定 俊之, 尾崎 敏文, 千田 益生

    The Japanese Journal of Rehabilitation Medicine   60 ( 特別号 )   3 - 3   2023年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 軟部肉腫に対する広範切除後の機能回復は成人患者と高齢患者でどのように異なるか? 下肢発生肉腫の検討

    藤原 智洋, 中田 英二, 近藤 彩奈, 堅山 佳美, 濱田 全紀, 国定 俊之, 尾崎 敏文, 千田 益生

    The Japanese Journal of Rehabilitation Medicine   60 ( 特別号 )   3 - 3   2023年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • Double plating via anterolateral and posterolateral approach for distal femoral fracture. 国際誌

    Yasuaki Yamakawa, Yasutaka Masada, Ryuichiro Okuda, Toshiyuki Matsumoto, Takenori Uehara, Masanori Yorimitsu, Tomoyuki Noda, Toshifumi Ozaki

    Trauma case reports   44   100803 - 100803   2023年4月

     詳細を見る

    記述言語:英語  

    Although there are some reports highlighting the applicability of double plates in distal femoral fractures, there is no standard approach or fixation method for supracondylar fractures combined with posterior coronal shear fractures. We report a case of distal femoral fracture treated with a lateral locking plate and posterior buttress plate using anterolateral and posterolateral approaches from one incision. A 70-year-old man was hit by a motorcycle and had an intra-articular distal femoral fracture involving a long medial proximal spike and a single lateral condyle fragment, with the lateral condyle fragment posteriorly displaced. A 12-cm lateral skin incision was made, and the joint was developed using a para-patellar approach from the anterior to iliotibial band. Posterior buttress plate fixation was successfully performed from behind the iliotibial band using a posterolateral approach, followed by cannulated cancellous screw and lateral locking plate fixation from the anterolateral window. Combined anterolateral and posterolateral approaches from one incision enable intra-articular exposure and fixation based on fixation principles for lateral condyle fragments combined with supracondylar fracture.

    DOI: 10.1016/j.tcr.2023.100803

    PubMed

    researchmap

  • ヒト多能性幹細胞から誘導した肢芽間葉系細胞と、その拡大培養法の開発

    中田 英二, 山田 大祐, 高尾 知佳, たき平 将太, 藤原 智洋, 尾崎 敏文, 宝田 剛志

    移植   57 ( 4 )   363 - 363   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

    researchmap

  • ヒトiPS細胞から誘導した肢芽間葉系細胞による軟骨シートの作製

    藤澤 佑樹, 高尾 知佳, 佐藤 正人, 豊田 恵利子, 山田 大祐, 中田 英二, 尾崎 敏文, 宝田 剛志

    移植   57 ( 4 )   362 - 362   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

    researchmap

  • Accuracy of the newly developed Zimmer Biomet Root Aiming guide in tibial tunnel creation compared with that of conventional guides. 国際誌

    Takaaki Hiranaka, Takayuki Furumatsu, Yuki Okazaki, Keisuke Kintaka, Naohiro Higashihara, Masanori Tamura, Eiji Nakata, Toshifumi Ozaki

    Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology   32   1 - 6   2023年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/OBJECTIVE: Accurate tibial tunnel creation is crucial for successful transtibial pullout repair of medial meniscus (MM) posterior root tears (MMPRTs). This study aimed to evaluate the accuracy of the newly developed Zimmer Biomet Root Aiming (ZeBRA) guide for transtibial pullout repair of MMPRTs. METHODS: This study included 50 patients who underwent transtibial pullout repair using the Unicorn Meniscal Root (UMR) (n = 25) and ZeBRA (n = 25) guides. The expected anatomic centre (AC) and tibial tunnel centre (TC) were assessed using three-dimensional postoperative computed tomography (CT) images. The expected AC was defined as the centre of the circle tangent to the triangular footprint of the MM posterior root. The expected AC and TC on the tibial surface were assessed using the percentage-based posterolateral location on the tibial surface. The absolute distance between the AC and TC (mm) was evaluated. RESULTS: The mean AC location was 76.1% ± 3.1% posterior and 40.8% ± 2.1% lateral, whereas the mean TC location was 76.7% ± 5.3% posterior and 37.2% ± 3.6% lateral using the UMR guide and 75.8% ± 3.1% posterior and 36.5% ± 2.4% lateral using the ZeBRA guide. No significant difference was observed in the absolute distance between the UMR and ZeBRA guides (3.9 ± 1.4 and 3.8 ± 1.3 mm, respectively; p = 0.617). CONCLUSIONS: The newly developed ZeBRA guide allows accurate tibial tunnel creation, and its accuracy is comparable to that of the conventional UMR guide. Tibial tunnels were created at optimal positions using both guides, and the choice of the guide would depend on the surgeon's preference.

    DOI: 10.1016/j.asmart.2023.03.001

    PubMed

    researchmap

  • Fracture Line Distributions of Undisplaced Distal Radius Fractures in Relation to Rupture of the Extensor Pollicis Longus Tendon.

    Hidenori Kondo, Taichi Saito, Ryuichi Nakahara, Ryo Nakamichi, Yasunori Shimamura, Ryozo Harada, Junya Imatani, Toshifumi Ozaki

    Acta medica Okayama   77 ( 2 )   179 - 184   2023年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Rupture of the extensor pollicis longus (EPL) tendon is a known complication after undisplaced distal radius fracture (DRF). However, no report has revealed the relationship between EPL tendon rupture and the fracture pattern. Thus, this study aimed to investigate the characteristics of fractures at risk of EPL tendon rupture using fracture line mapping of undisplaced DRFs. This study used computed tomography imaging data of undisplaced DRFs with (n=18) and without EPL tendon rupture (n=52). Fracture lines obtained from 3D reconstruction data were drawn manually after matching with a 2D template wrist model. Fracture maps represented the fracture line distribution by superimposing the fracture lines of all 70 patients. Heat maps showed the relative frequency of the fracture lines as a gradual color change. Fracture lines of cases with EPL tendon rupture were concentrated in the proximal border of Lister's tubercle. By contrast, fracture lines of cases without EPL tendon rupture were relatively dispersed.

    DOI: 10.18926/AMO/65147

    PubMed

    researchmap

  • 鏡視下手根管開放術と小切開手根管開放術の短期成績の比較検討

    中道 亮, 斎藤 太一, 島村 安則, 尾崎 敏文

    日本手外科学会雑誌   40 ( 1 )   O25 - 2   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本手外科学会  

    researchmap

  • 弾発指に対する術後リハビリテーションの有効性

    斎藤 太一, 中道 亮, 島村 安則, 西田 圭一郎, 尾崎 敏文

    日本手外科学会雑誌   40 ( 1 )   O32 - 2   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本手外科学会  

    researchmap

  • 野球選手における有鉤骨骨折に対する皮皺に沿った掌側進入法における手術治療成績

    島村 安則, 根津 智史, 斎藤 太一, 中道 亮, 山脇 正, 久禮 美穂, 西田 圭一郎, 尾崎 敏文

    日本手外科学会雑誌   40 ( 1 )   O38 - 5   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本手外科学会  

    researchmap

  • 内側半月板後根プルアウト修復術後の外側楔状足底板の使用は術後成績を改善する

    川田 紘己, 古松 毅之, 横山 裕介, 金高 圭甫, 東原 直裕, 田村 優典, 尾崎 敏文

    中国・四国整形外科学会雑誌   35 ( 1 )   186 - 186   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 片側下腿に発生した多発性グロムス腫瘍の一例

    徳田 貴大, 藤原 智洋, 近藤 彩奈, 国定 俊之, 中田 英二, 西村 碧フィリーズ, 柳井 広之, 尾崎 敏文

    中国・四国整形外科学会雑誌   35 ( 1 )   47 - 51   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    症例は21歳男性で、左下腿脛骨外側部のグロムス腫瘍切除術後2ヵ月経過した時点で左下腿の疼痛が再燃した。MRIでは左脛骨前面、脛骨後面、脛腓間、腓骨周囲に多発性の腫瘤を認め、これら全病変を辺縁切除した。病理検査では全てグロムス腫瘍と診断され、術後1年の時点で疼痛の再燃や腫瘍の再発は認めず、趣味のダンスも再開している。

    researchmap

  • Lenke type 1思春期特発性側彎症におけるHybrid法とSegmental Pedicle screw法による治療効果の検討

    魚谷 弘二, 三澤 治夫, 鉄永 倫子, 小田 孔明, 志渡澤 央和, 植田 昌敬, 尾崎 敏文

    Journal of Spine Research   14 ( 3 )   283 - 283   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

    researchmap

  • 骨粗鬆症治療を導入すべき脊椎手術を受ける患者の現状

    高尾 真一郎, 三澤 治夫, 小田 孔明, 魚谷 弘二, 鉄永 倫子, 山根 健太郎, 竹内 一裕, 尾崎 敏文, 中原 進之介

    Journal of Spine Research   14 ( 3 )   651 - 651   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

    researchmap

  • Malignant spinal Cord Compression(MSCC)を伴う転移性脊椎腫瘍患者に対する手術介入は生命予後を改善するのか

    志渡澤 央和, 魚谷 弘二, 三澤 治夫, 鉄永 倫子, 小田 孔明, 植田 昌敬, 尾崎 敏文

    Journal of Spine Research   14 ( 3 )   243 - 243   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

    researchmap

  • 重度骨粗鬆症性椎体骨折に対するCement catching screwの有用性

    三澤 治夫, 魚谷 弘二, 小田 孔明, 志渡澤 央和, 植田 昌敬, 尾崎 敏文

    Journal of Spine Research   14 ( 3 )   680 - 680   2023年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

    researchmap

  • Meniscus extrusion is a predisposing factor for determining arthroscopic treatments in partial medial meniscus posterior root tears. 国際誌

    Takayuki Furumatsu, Keisuke Kintaka, Naohiro Higashihara, Masanori Tamura, Koki Kawada, Haowei Xue, Toshifumi Ozaki

    Knee surgery & related research   35 ( 1 )   8 - 8   2023年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Patients with partial medial meniscus posterior root tears (MMPRTs) sometimes require arthroscopic pullout repair because of their intolerable/repeated knee pains and continuous disturbance in gait during activities of daily living. However, the predisposing factors for future knee surgery in patients with partial MMPRTs remain unclear. We compared the findings of magnetic resonance imaging (MRI) between patients who underwent pullout repair and nonoperative management following partial MMPRTs. METHODS: Twenty-five patients who required arthroscopic repair for partial MMPRTs and 23 patients who were managed nonoperatively were evaluated during a mean follow-up period of 27.1 months. Sex, age, height, body weight, body mass index, duration from onset to initial MRI, MRI findings, and medial meniscus (MM) extrusion were compared between the two groups. Linear regression analysis was used to assess the correlation between MM extrusion and duration from onset to MRI examination. RESULTS: No significant differences were observed between the pullout repair and nonoperative management groups in terms of patient demographics and the positive ratio of MRI-based root tear signs. However, absolute MM extrusion in the pullout repair group (3.49 ± 0.82 mm) was larger than that in the nonoperative management group (2.48 ± 0.60 mm, P < 0.001). Extrusion of the MM (> 3 mm) was detected more frequently in the pullout repair group than in the nonoperative management group (P < 0.001). The odds ratio in the pullout repair and MM extrusion > 3 mm cases was 9.662. Linear regression analysis revealed a fair correlation between the duration from onset to MRI and MM extrusion only in the pullout repair group (0.462 mm/month increase in MM extrusion). CONCLUSIONS: This study demonstrated that more severe MM extrusions were observed in the pullout repair group than in the nonoperative management group. Major extrusion (> 3 mm) was also observed more in the pullout repair group than in the nonoperative group. Assessing MM extrusion and its severity can help determine a valid treatment for patients with partial MMPRTs. LEVEL OF EVIDENCE: IV, Retrospective comparative study.

    DOI: 10.1186/s43019-023-00182-6

    PubMed

    researchmap

  • Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib. 国際誌

    Makoto Endo, Tomoko Kataoka, Toshifumi Fujiwara, Satoshi Tsukushi, Masanobu Takahashi, Eisuke Kobayashi, Yoko Yamada, Takaaki Tanaka, Yutaka Nezu, Hiroaki Hiraga, Junji Wasa, Akihito Nagano, Kenji Nakano, Robert Nakayama, Tetsuya Hamada, Masanori Kawano, Tomoaki Torigoe, Akio Sakamoto, Kunihiro Asanuma, Takeshi Morii, Ryunosuke Machida, Yuta Sekino, Haruhiko Fukuda, Yoshinao Oda, Toshifumi Ozaki, Kazuhiro Tanaka

    BMC cancer   23 ( 1 )   219 - 219   2023年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Soft tissue sarcomas (STS) are a rare type of malignancy comprising a variety of histological diagnoses. Chemotherapy constitutes the standard treatment for advanced STS. Doxorubicin-based regimens, which include the administration of doxorubicin alone or in combination with ifosfamide or dacarbazine, are widely accepted as first-line chemotherapy for advanced STS. Trabectedin, eribulin, pazopanib, and gemcitabine plus docetaxel (GD), which is the empirical standard therapy in Japan, are major candidates for second-line chemotherapy for advanced STS, although clear evidence of the superiority of any one regimen is lacking. The Bone and Soft Tissue Tumor Study Group of the Japan Clinical Oncology Group (JCOG) conducts this trial to select the most promising regimen among trabectedin, eribulin, and pazopanib for comparison with GD as the test arm regimen in a future phase III trial of second-line treatment for patients with advanced STS. METHODS: The JCOG1802 study is a multicenter, selection design, randomized phase II trial comparing trabectedin (1.2 mg/m2 intravenously, every 3 weeks), eribulin (1.4 mg/m2 intravenously, days 1 and 8, every 3 weeks), and pazopanib (800 mg orally, every day) in patients with unresectable or metastatic STS refractory to doxorubicin-based first-line chemotherapy. The principal eligibility criteria are patients aged 16 years or above; unresectable and/or metastatic STS; exacerbation within 6 months prior to registration; histopathological diagnosis of STS other than Ewing sarcoma, embryonal/alveolar rhabdomyosarcoma, well-differentiated liposarcoma and myxoid liposarcoma; prior doxorubicin-based chemotherapy for STS, and Eastern Cooperative Oncology Group performance status 0 to 2. The primary endpoint is progression-free survival, and the secondary endpoints include overall survival, disease-control rate, response rate, and adverse events. The total planned sample size to correctly select the most promising regimen with a probability of > 80% is 120. Thirty-seven institutions in Japan will participate at the start of this trial. DISCUSSION: This is the first randomized trial to evaluate trabectedin, eribulin, and pazopanib as second-line therapies for advanced STS. We endeavor to perform a subsequent phase III trial comparing the best regimen selected by this study (JCOG1802) with GD. TRIAL REGISTRATION: This study was registered with the Japan Registry of Clinical Trials ( jRCTs031190152 ) on December 5, 2019.

    DOI: 10.1186/s12885-023-10693-w

    PubMed

    researchmap

  • 腱滑膜巨細胞腫に対するザルトプロフェンのプラセボ対照無作為化二重盲検比較試験(第II相試験) The REALIZE study

    武内 章彦, 遠藤 誠, 川井 章, 西田 佳弘, 寺内 竜, 松峯 昭彦, 相羽 久輝, 中村 知樹, 丹代 晋, 尾崎 敏文, 土屋 弘行

    日本整形外科学会雑誌   97 ( 2 )   S88 - S88   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 悪性末梢神経鞘腫瘍におけるPRRX1の治療標的分子としての可能性

    たき平 将太, 中田 英二, 大曽根 達則, 山田 大祐, 高尾 知佳, 佐藤 浩平, 畑 利彰, 藤原 智洋, 国定 俊之, 宝田 剛志, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S1040 - S1040   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 生物学的製剤の使用は手術部位感染と創傷治癒遅延のリスク因子となるか

    木曽 洋平, 西田 圭一郎, 原田 遼三, 那須 義久, 中原 龍一, 渡辺 雅仁, 堀田 佳史, 浪花 崇一, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S1022 - S1022   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • [Ⅲ. The Role of Comprehensive Genomic Profiling in Sarcoma].

    Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, Toshifumi Ozaki, Shinichi Toyooka, Daisuke Ennishi, Hideki Yamamoto, Kiichiro Ninomiya, Shuta Tomida, Akira Hirasawa, Mashu Futagawa, Masahiro Tabata

    Gan to kagaku ryoho. Cancer & chemotherapy   50 ( 3 )   314 - 320   2023年3月

     詳細を見る

    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    PubMed

    researchmap

  • リウマチ性疾患における画像検査 教師なしAIを用いたトポロジー学習・関節リウマチ超音波画像同一断面自動検出

    中原 龍一, 西田 圭一郎, 那須 義久, 浪花 崇一, 堀田 佳史, 志水 紀之, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   67回   718 - 718   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • リウマチ性疾患の手術:周術期管理・手術関連諸問題 関節リウマチに対する整形外科手術後の手術部位感染・創傷治癒遅延の発生頻度と治癒過程はb/tsDMARD使用に影響されるか?

    浪花 崇一, 志水 紀之, 堀田 佳史, 中原 龍一, 那須 義久, 尾崎 敏文, 西田 圭一郎

    日本リウマチ学会総会・学術集会プログラム・抄録集   67回   691 - 691   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 生物学的製剤の使用は手術部位感染と創傷治癒遅延のリスク因子となるか

    木曽 洋平, 西田 圭一郎, 原田 遼三, 那須 義久, 中原 龍一, 渡辺 雅仁, 堀田 佳史, 浪花 崇一, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S1022 - S1022   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫におけるがんゲノム医療の現状と未来 がん遺伝子パネル検査から同定されるGermline Findingsへの対応

    二川 摩周, 中田 英二, 藤原 智洋, 国定 俊之, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S446 - S446   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Musculoskeletal Tumor 骨・軟部腫瘍 骨・軟部腫瘍におけるがん遺伝子プロファイリング検査 骨・軟部腫瘍診療におけるがん遺伝子パネルの役割

    中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文, 豊岡 伸一, 遠西 大輔, 山本 英喜, 二宮 貴一朗, 冨田 秀太, 平沢 晃, 二川 摩周, 田端 雅弘

    癌と化学療法   50 ( 3 )   314 - 320   2023年3月

  • 人工肘関節置換術-合併症に対する創意と工夫- 人工肘関節周囲骨折の治療戦略

    那須 義久, 志水 紀之, 浪花 崇一, 堀田 佳史, 原田 遼三, 西田 圭一郎, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S565 - S565   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 成長期の関節疾患治療アップデート 上腕骨小頭離断性骨軟骨炎の手術治療

    島村 安則, 斉藤 太一, 中道 亮, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S505 - S505   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • TSS法へのall-inside sutureの追加は内側半月板逸脱体積の抑制効果に乏しい

    金高 圭甫, 古松 毅之, 横山 裕介, 田村 優典, 川田 紘己, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   66 ( 春季学会 )   250 - 250   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • 内側半月板後根断裂に対する経脛骨pullout修復術 男女別比較

    東原 直裕, 古松 毅之, 横山 裕介, 金高 圭甫, 田村 優典, 川田 紘己, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S577 - S577   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 内側半月板後根断裂に対するpullout修復術 術後早期からの部分荷重および可動域訓練は治療成績を悪化させない

    田村 優典, 古松 毅之, 横山 裕介, 金高 圭甫, 東原 直裕, 川田 紘己, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S856 - S856   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 内側半月板後根プルアウト修復術 関節裂隙の狭小化はどの程度進行するのか

    川田 紘己, 古松 毅之, 田村 優典, Xue Haowei, 東原 直裕, 金高 圭甫, 横山 裕介, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S571 - S571   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • TSS法へのall-inside sutureの追加は内側半月板逸脱の抑制効果に乏しい

    金高 圭甫, 古松 毅之, 横山 裕介, 東原 直裕, 田村 優典, 川田 紘己, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S575 - S575   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 内側半月板後根プルアウト修復術後における関節裂隙狭小化の定量的評価

    川田 紘己, 古松 毅之, 横山 裕介, 金高 圭甫, 東原 直裕, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   66 ( 春季学会 )   250 - 250   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • Vertebral body collapse after radiotherapy for spinal metastases. 国際誌

    Eiji Nakata, Ryuichi Nakahara, Haruyoshi Katayama, Takuto Itano, Shinsuke Sugihara, Toshifumi Ozaki

    Oncology letters   25 ( 3 )   109 - 109   2023年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Spinal metastases are common in patients with advanced stages of cancer and frequently cause vertebral body collapse (VBC). Although conventional radiotherapy (RT) is used for spinal metastases, the rates of occurrence of new VBC and progression of VBC at RT initiation have not been fully investigated. The present retrospective study assessed VBC and its associated risk factors after RT over time and evaluated new VBC and progression of VBC in patients who presented with VBC at RT initiation. The study evaluated 177 patients who received RT for vertebral metastases without paralysis between July 2012 and November 2016. Radiological responses of the irradiated vertebrae were assessed using computed tomography. Follow-up assessments were performed at RT initiation and 1, 2, 3, 4 and 6 months after RT. New VBC occurred in 12% of patients with no prior VBC within 1 month of RT. Multivariate analysis revealed that numeric rating scale (NRS) score (≥4) [relative risk (RR), 27.1; 95% confidence interval (CI), 1.86 to 394.9; P=0.016] was associated with the occurrence of new VBC at the 1 month follow-up time point. VBC progression occurred in 51% of the patients with collapse at RT initiation. Multivariate analysis revealed that bone quality (lytic metastases) (RR, 3.1; 95% CI, 1.28 to 7.70; P=0.013), NRS score (≥4) (RR, 3.0; 95% CI, 1.18 to 7.45; P=0.021) and tumor involvement of posterolateral elements of the spine (RR, 2.7; 95% CI, 1.03 to 7.29; P=0.04) were associated with the progression of VBC at the 1 month follow-up time point. The current study findings suggested that clinicians should pay attention to the factors that predict the occurrence of new VBC and VBC progression to ensure proper evaluation of conservative treatment effectiveness and facilitate the determination of patients who need close monitoring.

    DOI: 10.3892/ol.2023.13695

    PubMed

    researchmap

  • 骨巨細胞腫に対するデノスマブのde-escalationの有効性

    板野 拓人, 中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S959 - S959   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨・軟部腫瘍診療におけるデジタルトランスフォーメーションとプレシジョン・メディシン Liquid biopsyを用いた骨・軟部腫瘍診療におけるプレシジョン・メディシンへの期待と課題

    藤原 智洋, 中田 英二, 畑 利彰, 近藤 彩奈, 板野 拓人, 吉田 晶, 片山 晴喜, 佐藤 浩平, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S613 - S613   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨・軟部腫瘍診療におけるデジタルトランスフォーメーションとプレシジョン・メディシン AIを用いた骨肉腫X線読影における転移学習の効果

    長谷井 嬢, 中原 龍一, 藤原 智洋, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S611 - S611   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫におけるがんゲノム医療の現状と未来 肉腫におけるがん遺伝子パネルの意義

    中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S445 - S445   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨盤の悪性腫瘍を究める 骨盤腫瘍に対する創外固定を併用したhip transposition法

    国定 俊之, 藤原 智洋, 中田 英二, 千田 益生, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S437 - S437   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 前腕に発生した肉腫の治療成績

    片山 晴喜, 中田 英二, 板野 拓人, 近藤 彩奈, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S321 - S321   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 高齢軟部肉腫患者において術後合併症の発生は生存予後に影響を与えるか

    近藤 彩奈, 藤原 智洋, 吉田 晶, 板野 拓人, 片山 晴喜, 佐藤 浩平, 畑 利彰, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S320 - S320   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 老年学的因子は浸潤性軟部肉腫患者の生存予後と相関するか

    畑 利彰, 藤原 智洋, 柳井 広之, 吉田 晶, 板野 拓人, 近藤 彩奈, 片山 晴喜, 佐藤 浩平, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S80 - S80   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • がんロコモ診療の課題と展望 周術期患者のがんロコモ・サルコペニア・フレイル

    堅山 佳美, 中田 英二, 濱田 全紀, 国定 俊之, 藤原 智洋, 千田 益生, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S18 - S18   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 小児AYA世代骨軟部腫瘍の課題と対策 遺伝性骨・軟部腫瘍外来の取り組み

    中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   66 ( 春季学会 )   58 - 58   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • 骨軟部腫瘍診療のサステナビリティ 原発性悪性骨腫瘍患者の居住地と診療施設間の地理的因子は予後と相関するか?米国の診療体制の現状と課題

    藤原 智洋, 中田 英二, 国定 俊之, 尾崎 敏文, 小倉 浩一, Healey John

    中部日本整形外科災害外科学会雑誌   66 ( 春季学会 )   54 - 54   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • 多診療科で考える脊椎転移の治療 骨転移診療システムによる麻痺予防の取り組み

    杉原 進介, 近藤 宏也, 中田 英二, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 3 )   S618 - S618   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 脛骨プラトー骨折と骨幹部骨折の合併骨折の手術的治療

    福岡 史朗, 依光 正則, 佐藤 浩平, 畑 利彰, 上原 健敬, 尾崎 敏文

    骨折   45 ( 2 )   508 - 511   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    【背景】脛骨プラトーおよび骨幹部の合併骨折は高エネルギー外傷に伴って認められることが多い.単一のインプラント固定では治療困難である場合も認められ,骨折型や軟部状態に応じて内固定方法の選択が重要である.【目的】比較的稀な脛骨プラトーおよび骨幹部骨折を合併した9例を経験し,骨折型による内固定方法の選択を検討したので報告する.【方法】2009~20年において,高エネルギー外傷で受傷した脛骨プラトーおよび骨幹部合併骨折に対して内固定を行い,骨癒合まで経過観察可能であった9例(男性5名,女性4名)を対象とし,骨折型と内固定方法を後ろ向きに検討した.【結果】平均年齢66(45~86)歳,受傷機転は交通外傷6例,転落外傷3例であった.そのうち開放骨折2例,コンパートメント症候群2例を認めた.内固定方法の内訳として,外側プレート固定1例,内側と外側のプレート固定(以下,ダブルプレート固定)3例,外側(内側)プレートおよび髄内釘固定4例,関節面スクリューおよび髄内釘固定1例であった.また外側プレートおよび髄内釘固定を予定していた1例において,術中に髄内釘挿入部近傍の骨折が顕在化し,整復位の保持が困難となったためダブルプレート固定に変更した.【結論】脛骨プラトー・骨幹部合併骨折の内固定方法として,外側プレート固定,ダブルプレート固定,外(内)側プレート(またはスクリュー)および髄内釘固定が報告されており,骨折型や骨幹部骨折の位置,軟部組織の状態が内固定方法の選択要因となっている.今回我々が経験した症例のなかで,術中の整復不良により内固定方法を変更した1例は,後方で脛骨プラトーと骨幹部にかけて骨折線が連続しており,髄内釘挿入のアプローチはinfrapatellar approachであった.他の同様な骨折型に対して髄内釘固定を行った症例では,suprapatellar approachが選択されていた.脛骨プラトーと骨幹部の骨折線が連続している不安定な骨折の場合には,suprapatellar approachが選択されるべきである.(著者抄録)

    researchmap

  • 解剖学的ランドマークを指標にした理想的なIAS挿入の位置と挿入角度の検討

    福岡 史朗, 依光 正則, 佐藤 浩平, 畑 利彰, 上原 健敬, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S244 - S244   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 脛骨骨折に対する異なるアプローチ間での髄内釘の挿入位置の検討

    福岡 史朗, 依光 正則, 上原 健敬, 寺田 忠司, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   66 ( 春季学会 )   195 - 195   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • 脛骨遠位骨幹部骨折に対するsemi-extended approachは術後足関節アライメントを悪化させない

    福岡 史朗, 依光 正則, 佐藤 浩平, 上原 健敬, 尾崎 敏文, 寺田 忠司

    骨折   45 ( 2 )   520 - 522   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    【背景】脛骨骨幹部骨折に対しては髄内釘固定が標準的治療である.しかしながら,脛骨近位および遠位骨幹部骨折においては,髄腔径が広いことや膝屈曲位での整復位の獲得およびその確認が困難なことから,変形癒合の報告が散見される.【目的】脛骨遠位骨幹部骨折における髄内釘固定において,infra-patellar approachとsemi-extended approachの2つのアプローチ間で術後整復位の比較を行い,適したアプローチを選択する.【研究デザイン】過去起点コホート研究.【設定】大学附属病院と関連病院の2施設.【対象】2012~21年において,脛骨遠位骨幹部骨折に対し髄内釘固定を行い,小児や骨癒合までフォローできなかった症例などを除外した56例(男性36例,女性20例)を対象とした.使用インプラントや免荷期間は各施設の判断に委ねた.【方法】2つのアプローチ間での術後整復位(正面天蓋角を測定し,内外反角の絶対値を計測)を比較検討した.また,年齢,性別,BMI,骨折型(AO/OTA分類),nail径,最峡部径,骨癒合期間についても比較を行った.各々の検討項目をFisher's exact test,Mann-Whitney U testを用い有意水準5%で群間比較検討した.【結果】Infra-patellar approach 37例,semi-extended approach 19例であり,内外反変形において有意差を認めた(infra-patellar:3.65°,semi-extended:2.11°,p<0.05).足関節アライメント以外の検討項目においてはアプローチ間での有意差は認めなかった.【結論】脛骨遠位骨幹部骨折における髄内釘固定後の足関節アライメントは,semi-extended approachの方がinfra-patellar approachよりも良好であった.(著者抄録)

    researchmap

  • 転移性骨腫瘍キャンサーボードの運用と課題 Malignant spinal Cord Compression(MSCC)を伴う転移性脊椎腫瘍患者に対する手術介入と生命予後の関係

    志渡澤 央和, 魚谷 弘二, 三澤 治夫, 小田 孔明, 植田 昌敬, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   66 ( 春季学会 )   106 - 106   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • 思春期特発性側彎症(Lenke type 1)におけるHybrid法とSegmental Pedicle screw法による治療効果の検討

    魚谷 弘二, 植田 昌敬, 志渡澤 央和, 小田 孔明, 三澤 治夫, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   66 ( 春季学会 )   329 - 329   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • Malignant spinal cord compression(MSCC)を伴う転移性脊椎腫瘍患者に対する手術介入は生命予後に影響するか

    志渡澤 央和, 魚谷 弘二, 三澤 治夫, 鉄永 倫子, 小田 孔明, 植田 昌敬, 尾崎 敏文

    日本整形外科学会雑誌   97 ( 2 )   S287 - S287   2023年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • A novel chondrocyte sheet fabrication using human-induced pluripotent stem cell-derived expandable limb-bud mesenchymal cells. 国際誌

    Tomoka Takao, Masato Sato, Yuki Fujisawa, Eriko Toyoda, Daisuke Yamada, Yukio Hitsumoto, Eiji Nakata, Toshifumi Ozaki, Takeshi Takarada

    Stem cell research & therapy   14 ( 1 )   34 - 34   2023年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Cell sheet fabrication for articular cartilage regenerative medicine necessitates a large number of chondrocytes of consistent quality as a cell source. Previously, we have developed human-induced pluripotent stem cell (iPSC)-derived expandable PRRX1+ limb-bud mesenchymal cells (ExpLBM) with stable expansion and high chondrogenic capacity, while in this study; our ExpLBM technology was combined with cell sheet engineering to assess its potential as a stable cell source for articular cartilage regeneration. METHODS: ExpLBM cells derived from human-induced pluripotent stem cells (hiPSCs), including 414C2 and Ff-KVs09 (HLA homozygous), were seeded onto a culture plate and two-dimensional chondrogenic induction (2-DCI) was initiated. After 2-DCI, ExpLBM-derived chondrocytes were stripped and transferred to temperature-responsive culture inserts and the chondrocyte sheets were histologically examined or transplanted into osteochondral knee defects of immunodeficient rats. RESULTS: Immunohistochemistry revealed that ExpLBM-derived cell sheets were positive for Safranin O, COL2, and ACAN but that they were negative for COL1 and RUNX2. Furthermore, the engrafted tissues in osteochondral knee defects in immunodeficient rats were stained with SafO, human VIMENTIN, ACAN, and COL2. CONCLUSIONS: The present study is the first to report the chondrocyte sheet fabrication with hiPSC-derived cell source. hiPSC-derived ExpLBM would be a promising cell source for cell sheet technology in articular cartilage regenerative medicine.

    DOI: 10.1186/s13287-023-03252-4

    PubMed

    researchmap

  • CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex. 国際誌

    Rongsheng Huang, Takahiro Yamamoto, Eiji Nakata, Toshifumi Ozaki, Kazuhiko Kurozumi, Fanyan Wei, Kazuhito Tomizawa, Atsushi Fujimura

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)   e2206542   2023年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Cancer stem-like cells (CSCs) have a unique translation mode, but little is understood about the process of elongation, especially the contribution of tRNA modifications to the maintenance of CSCs properties. Here, it is reported that, contrary to the initial aim, a tRNA-modifying methylthiotransferase CDKAL1 promotes CSC-factor SALL2 synthesis by assembling the eIF4F translation initiation complex. CDKAL1 expression is upregulated in patients with worse prognoses and is essential for maintaining CSCs in rhabdomyosarcoma (RMS) and common cancers. Translatome analysis reveals that a group of mRNAs whose translation is CDKAL1-dependent contains cytosine-rich sequences in the 5' untranslated region (5'UTR). Mechanistically, CDKAL1 promotes the translation of such mRNAs by organizing the eIF4F translation initiation complex. This complex formation does not require the enzyme activity of CDKAL1 but requires only the NH2 -terminus domain of CDKAL1. Furthermore, sites in CDKAL1 essential for forming the eIF4F complex are identified and discovered candidate inhibitors of CDKAL1-dependent translation.

    DOI: 10.1002/advs.202206542

    PubMed

    researchmap

  • Association of phase angle with sarcopenia in chronic musculoskeletal pain patients: a retrospective study. 国際誌

    Hironori Tsuji, Tomoko Tetsunaga, Haruo Misawa, Keiichiro Nishida, Toshifumi Ozaki

    Journal of orthopaedic surgery and research   18 ( 1 )   87 - 87   2023年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: In chronic musculoskeletal pain patients, detection of sarcopenia is of significant clinical interest. Phase angle, which can be measured through bioelectrical impedance analysis (BIA), can detect sarcopenia; however, the evidence in chronic musculoskeletal pain patients is limited. This study aimed to assess the relationship between phase angle and sarcopenia in patients with chronic musculoskeletal pain. Our hypothesis was that phase angle would be a useful indicator to identify sarcopenia in patients with chronic musculoskeletal pain. METHODS: A total of 190 patients (51 men and 139 women) with chronic musculoskeletal pain were included in this retrospective cross-sectional study. Patient data of backgrounds, numeric rating scale score for pain, skeletal muscle index, and phase angle assessed using BIA were retrospectively reviewed. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia criteria 2019. RESULTS: A total of 51 patients (26.7%), including 10 men (19.6%) and 41 women (29.5%), were diagnosed with sarcopenia. Phase angle, sarcopenia-related factors, age, and body mass index (BMI) differed significantly in patients with and without sarcopenia. On multiple logistic regression analysis, the prevalence of sarcopenia was significantly correlated with phase angle and BMI. The areas under the curve exhibited high accuracy in discriminating sarcopenia in men and moderate accuracy in both sexes and in women. CONCLUSIONS: Phase angle may be a valid discriminator of sarcopenia in patients with chronic musculoskeletal pain.

    DOI: 10.1186/s13018-023-03567-1

    PubMed

    researchmap

  • 悪性末梢神経鞘腫瘍におけるPRRX1の悪性化因子としての役割

    たき平 将太, 中田 英二, 山田 大祐, 片山 晴喜, 畑 利彰, 藤原 智洋, 高尾 知佳, 国定 俊之, 宝田 剛志, 尾崎 敏文

    日本レックリングハウゼン病学会学術大会プログラム・抄録集   14回   16 - 16   2023年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本レックリングハウゼン病学会  

    researchmap

  • 神経線維腫症1型における院内レジストリの構築と定期的なサーベイランスの実施

    二川 摩周, 中田 英二, 十川 麗美, 加藤 芙美乃, 浦川 優作, 山本 英喜, 藤原 智洋, 国定 俊之, 平沢 晃, 尾崎 敏文

    日本レックリングハウゼン病学会学術大会プログラム・抄録集   14回   34 - 34   2023年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本レックリングハウゼン病学会  

    researchmap

  • 遺伝性骨・軟部腫瘍外来におけるNF-1の診療

    中田 英二, 二川 摩周, 藤原 智洋, 国定 俊之, 山本 英喜, 平沢 晃, 尾崎 敏文

    日本レックリングハウゼン病学会学術大会プログラム・抄録集   14回   33 - 33   2023年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本レックリングハウゼン病学会  

    researchmap

  • Panner病の治療成績

    石原 健嗣, 島村 安則, 中道 亮, 齋藤 太一, 尾崎 敏文

    日本肘関節学会雑誌   30 ( 1 )   S312 - S312   2023年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本肘関節学会  

    researchmap

  • Self-controlled case seriesを用いた内側型野球肘からTommy John手術へのリスク比

    根津 智史, 島村 安則, 中道 亮, 齋藤 太一, 三橋 利晴, 尾崎 敏文

    日本肘関節学会雑誌   30 ( 1 )   S80 - S80   2023年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本肘関節学会  

    researchmap

  • 関節面再建・温存手術 上腕骨滑車部骨軟骨障害に対する鏡視下骨軟骨柱移植の治療成績

    島村 安則, 根津 智史, 中道 亮, 齋藤 太一, 名越 充, 尾崎 敏文

    日本肘関節学会雑誌   30 ( 1 )   S89 - S89   2023年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本肘関節学会  

    researchmap

  • Effectivity of the Outside-In Pie-Crusting Technique and an All-Inside Meniscal Repair Device in the Repair of Ramp Lesions. 国際誌

    Koki Kawada, Takayuki Furumatsu, Masanori Tamura, Haowei Xue, Naohiro Higashihara, Keisuke Kintaka, Yusuke Yokoyama, Toshifumi Ozaki

    Arthroscopy techniques   12 ( 2 )   e273-e278   2023年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Ramp lesions are characteristic medial meniscus injuries seen in anterior cruciate ligament-injured knees. Anterior cruciate ligament injuries combined with ramp lesions increase the amount of anterior tibial translation and tibial external rotation. Therefore, the diagnosis and treatment of ramp lesions have received increasing attention. However, ramp lesions can be difficult to diagnose on preoperative magnetic resonance imaging. Additionally, ramp lesions are difficult to observe and treat intraoperatively in the posteromedial compartment. Although good results have been reported with the use of a suture hook through the posteromedial portal in the treatment of ramp lesions, the complexity and difficulty of the technique are further problems. The outside-in pie-crusting technique is a simple procedure that can enlarge the medial compartment and facilitate the observation and repair of ramp lesions. After this technique, ramp lesions can be properly sutured, using an all-inside meniscal repair device, without damaging the surrounding cartilage. A combination of the outside-in pie-crusting technique and an all-inside meniscal repair device (with only anterior portals) is effective in the repair of ramp lesions. This Technical Note aims to report in detail the flow of a series of techniques, including our diagnostic and therapeutic methods.

    DOI: 10.1016/j.eats.2022.11.002

    PubMed

    researchmap

  • Comparison of screw versus locking plate fixation via sinus tarsi approach for displaced intra-articular calcaneal fractures. 国際誌

    Kohei Sato, Masanori Yorimitsu, Takenori Uehara, Shiro Fukuoka, Toshiaki Hata, Kenta Saiga, Tomoyuki Noda, Toshifumi Ozaki

    Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons   29 ( 1 )   97 - 102   2023年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The optimal treatment of displaced intra-articular calcaneal fractures (DIACF) is controversial. This study compared the fixation stability of screws and locking plates in DIACF treated via the sinus tarsi approach (STA). METHODS: We retrospectively evaluated 118 DIACF cases treated via STA and extracted data that could affect treatment outcomes. Loss of Böhler's angle after surgery was measured to compare fixation stability. RESULTS: The loss of Böhler's angles was significantly smaller in the locking plate group than in the screw group (2.6 ± 2.7º vs. 5.6 ± 5.3º, P < 0.01). There was no difference in the clinical outcomes between the groups. On multivariate logistic regression analysis, screw fixation was significantly associated with loss of Böhler's angle by> 10º (odds ratio, 8.63; 95% confidence interval, 1.16-64.4; P < 0.05). CONCLUSIONS: Locking plate fixation is more reliable than screw fixation for preventing correction loss in DIACF treated via STA. LEVEL OF EVIDENCE: III.

    DOI: 10.1016/j.fas.2022.11.002

    PubMed

    researchmap

  • 関節リウマチにおける手指関節・手関節の超音波パワードプラスコアと関節破壊の関連

    沖田 駿治, 中原 龍一, 那須 義久, 西田 圭一郎, 尾崎 敏文

    日本手外科学会雑誌   39 ( 4 )   524 - 527   2023年1月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本手外科学会  

    関節リウマチ患者において,関節超音波検査(以下US)で滑膜炎を認めた関節と関節破壊が進行する関節は必ずしも一致しないことが報告されている.USで評価を行った手指・手関節の関節破壊に対する予後を検討した.調査開始時にUSによるパワードプラ(以下PD)スコアの計測が行われ,調査開始時および調査開始後1年以上経過時に両手単純X線写真による関節破壊の進行が評価可能であった関節リウマチ患者70例を対象とした.多変量解析ではPDスコアの合計値のみが関節破壊の有意な危険因子として同定された(オッズ比1.19,P=0.010).両手のPDスコアの合計値は手関節の関節破壊(P=0.001)およびMCP関節の関節破壊(P<0.001)と相関を認めた.各関節のPDスコアは同関節の関節破壊と相関を認めた(P<0.001).諸家の報告と異なりUSで滑膜炎を認めた関節は関節破壊が進行しやすい結果であった.(著者抄録)

    researchmap

  • Outcome of unlinked total elbow arthroplasty for rheumatoid arthritis in patients younger than 50 years old. 国際誌

    Keiichiro Nishida, Yoshihisa Nasu, Kenzo Hashizume, Shunji Okita, Ryuichi Nakahara, Taichi Saito, Toshifumi Ozaki, Hajime Inoue

    Bone & joint open   4 ( 1 )   19 - 26   2023年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: There are concerns regarding complications and longevity of total elbow arthroplasty (TEA) in young patients, and the few previous publications are mainly limited to reports on linked elbow devices. We investigated the clinical outcome of unlinked TEA for patients aged less than 50 years with rheumatoid arthritis (RA). METHODS: We retrospectively reviewed the records of 26 elbows of 21 patients with RA who were aged less than 50 years who underwent primary TEA with an unlinked elbow prosthesis. The mean patient age was 46 years (35 to 49), and the mean follow-up period was 13.6 years (6 to 27). Outcome measures included pain, range of motion, Mayo Elbow Performance Score (MEPS), radiological evaluation for radiolucent line and loosening, complications, and revision surgery with or without implant removal. RESULTS: The mean MEPS significantly improved from 47 (15 to 70) points preoperatively to 95 (70 to 100) points at final follow-up (p < 0.001). Complications were noted in six elbows (23%) in six patients, and of these, four with an ulnar neuropathy and one elbow with postoperative traumatic fracture required additional surgeries. There was no revision with implant removal, and there was no radiological evidence of loosening around the components. With any revision surgery as the endpoint, the survival rates up to 25 years were 78.1% (95% confidence interval 52.8 to 90.6) as determined by Kaplan-Meier analysis. CONCLUSION: The clinical outcome of primary unlinked TEA for young patients with RA was satisfactory and comparable with that for elderly patients. A favourable survival rate without implant removal might support the use of unlinked devices for young patients with this disease entity, with a caution of a relatively high complication rate regarding ulnar neuropathy.Level of Evidence: Therapeutic Level IVCite this article: Bone Jt Open 2023;4(1):19-26.

    DOI: 10.1302/2633-1462.41.BJO-2022-0151.R1

    PubMed

    researchmap

  • 踵骨関節内骨折に対する低侵襲ロッキングプレート固定は早期荷重を可能とさせる

    國富 康資, 依光 正則, 上原 健敬, 福岡 史朗, 佐藤 浩平, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   66 ( 1 )   139 - 140   2023年1月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    当院で踵骨関節内骨折に対し治療を行った24例を対象に、これらをスクリュー固定を行った11例(S群)とロッキングプレート固定を行った14例(LP群)に分け、臨床成績を比較検討した。その結果、S群と比べ、LP群では最終調査時のBoehler角が有意に良好で、Boehler角の矯正損失は有意に少なかった。最終調査時のAOFAS score(AOFAS)は両群間で有意差がなかったものの、LP群の方がscoreが高い傾向がみられた。また、最終のBoehle角とAOFASの間には相関は認められなかったが、術後の横径とAOFASの間には有意な相関が認められた。以上より、踵骨関節内骨折に対するロッキングプレート固定は術後成績を低下させず、荷重時期を短縮する上で有用と考えられた。

    researchmap

    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00831&link_issn=&doc_id=20230519070065&doc_link_id=10.11359%2Fchubu.2023.139&url=https%3A%2F%2Fdoi.org%2F10.11359%2Fchubu.2023.139&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

  • The Evaluation of Meniscus Regenerative Effects 2 of LIPUS-Induced CCN Proteins: Induction by LIPUS of CCN2 3 and Meniscus-Related Genes in Cultured Meniscus Cells 4 and Meniscus Tissues

    Yusuke Kamatsuki, Eriko Aoyama, Takayuki Furumatsu, Toshifumi Ozaki, Masaharu Takigawa

    Methods in Molecular Biology   2582   223 - 235   2023年

     詳細を見る

    掲載種別:論文集(書籍)内論文   出版者・発行元:Springer US  

    DOI: 10.1007/978-1-0716-2744-0_15

    researchmap

  • 関節リウマチによる高度手関節変形に対して手関節全固定術あるいは人工手関節置換術を行った8例の術後経過

    市川 千夏, 西田 圭一郎, 志水 紀之, 浪花 崇一, 堀田 佳史, 中原 龍一, 那須 義久, 尾崎 敏文

    関節の外科   50 ( 2 )   122 - 122   2023年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本リウマチの外科学会  

    researchmap

  • 関節リウマチ患者に対するSauve-Kapandji法の臨床成績の検討

    志水 紀之, 西田 圭一郎, 市川 千夏, 浪花 崇一, 中原 龍一, 那須 義久, 尾崎 敏文

    関節の外科   50 ( 2 )   121 - 121   2023年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本リウマチの外科学会  

    researchmap

  • Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing. 国際誌

    Kazuki Hirose, Miho Kuwahara, Eiji Nakata, Tomonori Tetsunaga, Kazuki Yamada, Kenta Saiga, Masaharu Takigawa, Toshifumi Ozaki, Satoshi Kubota, Takako Hattori

    International journal of molecular sciences   23 ( 23 )   2022年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Osteoarthritis (OA) occurs not only in the knee but also in peripheral joints throughout the whole body. Previously, we have shown that the expression of cellular communication network factor 3 (CCN3), a matricellular protein, increases with age in knee articular cartilage, and the misexpression of CCN3 in cartilage induces senescence-associated secretory phenotype (SASP) factors, indicating that CCN3 promotes cartilage senescence. Here, we investigated the correlation between CCN3 expression and OA degenerative changes, principally in human femoral head cartilage. Human femoral heads obtained from patients who received total hip arthroplasty were categorized into OA and femoral neck fracture (normal) groups without significant age differences. Gene expression analysis of RNA obtained from femoral head cartilage revealed that CCN3 and MMP-13 expression in the non-weight-bearing part was significantly higher in the OA group than in the normal group, whereas the weight-bearing OA parts and normal cartilage showed no significant differences in the expression of these genes. The expression of COL10A1, however, was significantly higher in weight-bearing OA parts compared with normal weight-bearing parts, and was also higher in weight-bearing parts compared with non-weight-bearing parts in the OA group. In contrast, OA primary chondrocytes from weight-bearing parts showed higher expression of CCN3, p16, ADAMTS4, and IL-1β than chondrocytes from the corresponding normal group, and higher ADAMTS4 and IL-1β in the non-weight-bearing part compared with the corresponding normal group. Acan expression was significantly lower in the non-weight-bearing group in OA primary chondrocytes than in the corresponding normal chondrocytes. The expression level of CCN3 did not show significant differences between the weight-bearing part and non-weight-bearing part in both OA and normal primary chondrocytes. Immunohistochemical analysis showed accumulated CCN3 and aggrecan neoepitope staining in both the weight-bearing part and non-weight-bearing part in the OA group compared with the normal group. The CCN3 expression level in cartilage had a positive correlation with the Mankin score. X-ray analysis of cartilage-specific CCN3 overexpression mice (Tg) revealed deformation of the femoral and humeral head in the early stage, and immunohistochemical analysis showed accumulated aggrecan neoepitope staining as well as CCN3 staining and the roughening of the joint surface in Tg femoral and humeral heads. Primary chondrocytes from the Tg femoral head showed enhanced expression of Ccn3, Adamts5, p16, Il-6, and Tnfα, and decreased expression of Col2a1 and -an. These findings indicate a correlation between OA degenerative changes and the expression of CCN3, irrespective of age and mechanical loading. Furthermore, the Mankin score indicates that the expression level of Ccn3 correlates with the progression of OA.

    DOI: 10.3390/ijms232315311

    PubMed

    researchmap

  • Standardization of evaluation method and prognostic significance of histological response to preoperative chemotherapy in high-grade non-round cell soft tissue sarcomas 国際誌

    Yoshinao Oda, Kazuhiro Tanaka, Takanori Hirose, Tadashi Hasegawa, Nobuyuki Hiruta, Masanori Hisaoka, Masato Yoshimoto, Hiroshi Otsuka, Hirofumi Bekki, Takeaki Ishii, Makoto Endo, Toshiyuki Kunisada, Toru Hiruma, Hiroyuki Tsuchiya, Hirohisa Katagiri, Yoshihiro Matsumoto, Akira Kawai, Robert Nakayama, Hiroyuki Kawashima, Satoshi Takenaka, Makoto Emori, Munenori Watanuki, Yukihiro Yoshida, Takeshi Okamoto, Junki Mizusawa, Haruhiko Fukuda, Toshifumi Ozaki, Yukihide Iwamoto, Takayuki Nojima

    BMC Cancer   22 ( 1 )   94 - 94   2022年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Background

    Preoperative chemotherapy is widely applied to high-grade localized soft tissue sarcomas (STSs); however, the prognostic significance of histological response to chemotherapy remains controversial. This study aimed to standardize evaluation method of histological response to chemotherapy with high agreement score among pathologists, and to establish a cut-off value closely related to prognosis.

    Methods

    Using data and specimens from the patients who had registered in the Japan Clinical Oncology Group study, JCOG0304, a phase II trial evaluating the efficacy of perioperative chemotherapy with doxorubicin (DOX) and ifosfamide (IFO), we evaluated histological response to preoperative chemotherapy at the central review board.

    Results

    A total of 64 patients were eligible for this study. The percentage of viable tumor area ranged from 0.1% to 97.0%, with median value of 35.7%. Regarding concordance proportion between pathologists, the weighted kappa coefficient (κ) score in all patients was 0.71, indicating that the established evaluation method achieved substantial agreement score. When the cut-off value of the percentage of the residual tumor area was set as 25%, the p-value for the difference in overall survival showed the minimum value. Hazard ratio of the non-responder with percentage of the residual tumor &lt; 25%, to the responder was 4.029 (95% confidence interval 0.893–18.188, p = 0.070).

    Conclusion

    The standardized evaluation method of pathological response to preoperative chemotherapy showed a substantial agreement in the weighted κ score. The evaluation method established here was useful for estimating of the prognosis in STS patients who were administered perioperative chemotherapy with DOX and IFO.

    Trial registration

    UMIN Clinical Trials Registry C000000096. Registered 30 August, 2005 (retrospectively registered).

    DOI: 10.1186/s12885-022-09195-y

    PubMed

    researchmap

    その他リンク: https://link.springer.com/article/10.1186/s12885-022-09195-y/fulltext.html

  • Large flexion contracture angle predicts tight extension gap during navigational posterior stabilized-type total knee arthroplasty with the pre-cut technique: a retrospective study

    Takaaki Hiranaka, Shinichi Miyazawa, Takayuki Furumatsu, Yuya Kodama, Yusuke Kamatsuki, Shin Masuda, Yuki Okazaki, Keisuke Kintaka, Toshifumi Ozaki

    BMC Musculoskeletal Disorders   23 ( 1 )   2022年12月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Background

    This study aimed to determine the predictors of tight extension gap (EG) compared with the flexion gap (FG) during navigational posterior stabilized-type total knee arthroplasty using the pre-cut technique.

    Methods

    Nineteen patients with tight EG (defined as FG-EG ≥2 mm after pre-cut; group T) and 84 patients with an approximately equal gap (defined as FG-EG = 0–1 mm after pre-cut; group E) were enrolled. Medial tibial slope angle, hip knee ankle angle, flexion contracture angle, and active maximum flexion angle were compared between the two groups.

    Results

    The multivariate logistic regression model indicated that the probability of tight EG increased with flexion contracture angle (odds ratio, 1.13; 95% confidence interval 1.05–1.20; P ≤ 0.001). According to the receiver operating characteristic analysis, the flexion contracture angle cut-off value associated with tight EG was 15.0° (sensitivity, 85%; specificity, 78%).

    Conclusion

    This study demonstrated that a large flexion contracture angle (cut-off 15.0°) was associated with tight EG after pre-cut osteotomy during posterior stabilized-type total knee arthroplasty. Awareness of this risk factor may help improve preoperative predictability of tight EGs and preparedness for additional procedures, such as soft tissue release or capsulotomy, to correct them.

    Level of evidence

    Level III.

    DOI: 10.1186/s12891-022-05035-z

    researchmap

    その他リンク: https://link.springer.com/article/10.1186/s12891-022-05035-z/fulltext.html

  • 尺骨突き上げ症候群に対する尺骨骨幹部短縮骨切り術と遠位部短縮骨切り術の治療成績の比較

    齋藤 太一, 中道 亮, 島村 安則, 西田 圭一郎, 尾崎 敏文

    日本手外科学会雑誌   39 ( 3 )   315 - 318   2022年12月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本手外科学会  

    当院では以前より尺骨突き上げ症候群に対しては尺骨骨幹部での短縮骨切りを施行してきたが,近年皮膚切開量が短く,骨癒合が有利な尺骨遠位部での骨切りをおこなっている.今回骨切り部位別に治療成績を比較検討したので報告する.尺骨突き上げ症候群に対して骨切り術を行い,術後評価可能であった37例を対象とした.骨幹部骨切り症例は15例,遠位部骨切り症例は,22例含まれていた.これらの群に対して平均の骨癒合期間,握力,手関節可動域,DASH,Pain-VAS,および術後合併症をそれぞれ比較した.平均骨癒合期間は骨幹部骨切り群では3.3ヵ月,遠位部骨切り群では2.6ヵ月,術後1年経過時の握力については骨幹部,遠位部骨切り群それぞれ平均31.7kg,30.2kgであった.術後1年経過時の掌背屈可動域は骨幹部,遠位部骨切り群それぞれ150.0度,152.7度,回内外可動域は骨幹部,遠位部骨切り群それぞれ155.0度,170.1度であり,平均術後成績に有意差は認められなかった.DASHに関しては骨幹部骨切りでは23.9から20.1,遠位部骨切りでは33.3から9.9へと遠位部骨切りに関してのみ術後有意差をもって改善していた.またVASを用いた痛み評価では骨幹部骨切りでは7.2から1.0,遠位部骨切りでは5.8から1.2へとどちらの群も有意差をもって改善していた.(著者抄録)

    researchmap

  • 後期高齢者頸椎損傷の急性期手術介入のタイミングにコロナ禍は影響したか

    魚谷 弘二, 植田 昌敬, 志渡澤 央和, 小田 孔明, 鉄永 倫子, 三澤 治夫, 尾崎 敏文

    西日本脊椎研究会抄録集   96回   21 - 21   2022年12月

     詳細を見る

    記述言語:日本語   出版者・発行元:西日本脊椎研究会  

    researchmap

  • Five cases of atypical ulnar fractures associated with long-term bisphosphonate use: An anatomical and mechanical analysis using a finite element model

    Shunji Okita, Taichi Saito, Norio Yamamoto, Yusuke Mochizuki, Ryuichi Nakahara, Yasunori Shimamura, Toshiyuki Kunisada, Keiichiro Nishida, Toshifumi Ozaki

    Journal of Orthopaedic Science   2022年11月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.jos.2022.09.017

    researchmap

  • Clinical evaluation of suture materials for transtibial pullout repair of medial meniscus posterior root tear 国際誌

    Takaaki Hiranaka, Takayuki Furumatsu, Yuki Okazaki, Keisuke Kintaka, Yusuke Kamatsuki, Ximing Zhang, Haowei Xue, Masanori Hamada, Toshifumi Ozaki

    Knee Surgery &amp; Related Research   34 ( 1 )   39 - 39   2022年10月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Background

    There are no recommendations for specific suture materials in transtibial pullout repair of medial meniscus posterior root tears. This study aimed to evaluate the clinical outcomes of transtibial pullout repair of medial meniscus posterior root tears using ultrahigh-molecular-weight polyethylene sutures and suture tape.

    Methods

    We retrospectively reviewed the data of 36 patients (27 women and 9 men, mean age 64.1 years) who had undergone transtibial pullout repair of medial meniscus posterior root tears between November 2018 and December 2019. Two groups of 18 patients each received either two different cord-like sutures or suture tape. Clinical parameters were assessed preoperatively and on second-look arthroscopy (mean postoperative period 12 months). The meniscal healing status was assessed using a previously published scoring system (ranging from 0 to 10), and the incidence rate of suture cut-out was assessed on second-look arthroscopy.

    Results

    All clinical scores significantly improved in both groups, with no significant between-group differences on second-look arthroscopy. The arthroscopic meniscal healing scores significantly differed between sutures (mean 6.7 points) and suture tape (mean 7.4 points; p = 0.044). No significant between-group difference in the suture cut-out rate was observed.

    Conclusions

    This study found no significant differences in the clinical outcomes between ultrahigh-molecular-weight polyethylene sutures and suture tape. Favorable clinical outcomes were obtained using both types of suture; however, the usefulness of suture tape appears to be limited.

    DOI: 10.1186/s43019-022-00167-x

    PubMed

    researchmap

    その他リンク: https://link.springer.com/article/10.1186/s43019-022-00167-x/fulltext.html

  • Clinical outcomes of medial meniscus posterior root repair: A midterm follow-up study

    Takayuki Furumatsu, Shinichi Miyazawa, Yuya Kodama, Yusuke Kamatsuki, Yoshiki Okazaki, Takaaki Hiranaka, Yuki Okazaki, Keisuke Kintaka, Toshifumi Ozaki

    The Knee   38   141 - 147   2022年10月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.knee.2022.08.010

    researchmap

  • 運動器慢性疼痛患者において生理的インピーダンス法における位相角はサルコペニア検出に有用である

    辻 寛謙, 鉄永 倫子, 鉄永 智紀, 高尾 真一郎, 西田 圭一郎, 尾崎 敏文

    Journal of Musculoskeletal Pain Research   14 ( 4 )   S49 - S49   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本運動器疼痛学会  

    researchmap

  • 当院におけるAR Hip Navigation Systemのカップアライメント精度

    井上 智博, 鉄永 智紀, 山田 和希, 廣瀬 一樹, 小浦 卓, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   388 - 388   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 人工股関節全置換術における軟部組織保護に対する取り組み

    小浦 卓, 鉄永 智紀, 山田 和希, 廣瀬 一樹, 井上 智博, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   389 - 389   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • THA後の腸腰筋障害とその対策

    廣瀬 一樹, 山田 和希, 鉄永 智紀, 小浦 卓, 井上 智博, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   392 - 392   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • THA後の腸腰筋障害に対する股関節鏡下腸腰筋腱部分切離術の治療経験

    安藤 輝彦, 山田 和希, 鉄永 智紀, 佐藤 嘉洋, 廣瀬 一樹, 小浦 卓, 井上 智博, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   392 - 392   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 軟部肉腫に対する薬物療法 がん遺伝子パネルに基づく肉腫診療

    中田 英二, 藤原 智洋, 国定 俊之, 平沢 晃, 遠西 大輔, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   65 ( 秋季学会 )   77 - 77   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • がん遺伝子パネルに基づく肉腫診療

    中田 英二, 藤原 智洋, 平沢 晃, 二川 摩周, 遠西 大輔, 山本 英喜, 冨田 秀太, 久保 寿夫, 田端 雅弘, 国定 俊之, 豊岡 伸一, 尾崎 敏文

    日本癌治療学会学術集会抄録集   60回   O49 - 4   2022年10月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌治療学会  

    researchmap

  • 骨盤下肢外傷患者における静脈血栓塞栓症スクリーニングとしてのD-ダイマー値の妥当性

    佐藤 浩平, 上原 健敬, 浪花 崇一, 福岡 史朗, 畑 利彰, 依光 正則, 堅山 佳美, 濱田 全紀, 千田 益生, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S354 - S354   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • AIを用いた超音波画像同一断面自動保存機能の開発

    中原 龍一, 西田 圭一郎, 那須 義久, 堀田 佳史, 浪花 崇一, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   375 - 375   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • がん遺伝子パネルに基づく肉腫診療

    中田 英二, 藤原 智洋, 平沢 晃, 二川 摩周, 遠西 大輔, 山本 英喜, 冨田 秀太, 久保 寿夫, 田端 雅弘, 国定 俊之, 豊岡 伸一, 尾崎 敏文

    日本癌治療学会学術集会抄録集   60回   O49 - 4   2022年10月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌治療学会  

    researchmap

  • 両側の人工肘関節置換術術後に異所性骨化を生じた1例

    志水 紀之, 浪花 崇一, 堀田 佳史, 中原 龍一, 那須 義久, 西田 圭一郎, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   406 - 406   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 脆弱性骨盤輪骨折患者の急性期リハビリテーション医療

    浪花 崇一, 佐藤 浩平, 畑 利彰, 福岡 史朗, 上原 健敬, 堅山 佳美, 依光 正則, 濱田 全紀, 尾崎 敏文, 千田 益生

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S355 - S355   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 機械刺激応答性チャネルPIEZO1は運動刺激を感知して腱の成長を促進する

    中道 亮, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   374 - 374   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 骨軟部腫瘍の治療と予後因子についての考察

    中村 伸子, 長谷部 晋士, 山中 伸太郎, 藤井 知美, 藤渕 剛次, 木谷 彰岐, 佐藤 康史, 新藤 芳太郎, 西庄 俊彦, 尾崎 敏文, 田端 雅弘, 薬師神 芳洋

    日本癌治療学会学術集会抄録集   60回   P68 - 5   2022年10月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌治療学会  

    researchmap

  • 内側半月板後根断裂に対する経脛骨pullout修復術 脛骨固定時の膝屈曲角度と初期固定張力の違いによる臨床成績の比較

    田村 優典, 古松 毅之, 横山 裕介, 金高 圭甫, 東原 直裕, 川田 紘己, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   379 - 379   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • がんロコモを予防するための骨転移患者のマネージメント データに基づく骨転移診療

    中田 英二, 濱田 全紀, 国定 俊之, 藤原 智洋, 堅山 佳美, 千田 益生, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S322 - S322   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 小児固形腫瘍における基礎・トランスレーショナル研究の現状と展望 骨軟部肉腫における基礎・トランスレーショナル研究の現状と展望

    藤原 智洋, 中田 英二, 国定 俊之, 尾崎 敏文

    日本小児血液・がん学会雑誌   59 ( 4 )   169 - 169   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本小児血液・がん学会  

    researchmap

  • 片側下腿に発生した多発性グロムス腫瘍の一例

    徳田 貴大, 藤原 智洋, 国定 俊之, 中田 英二, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   395 - 395   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 下肢長幹骨発生の原発性悪性骨腫瘍に対する広範切除術後の機能回復は再建法によりどのように異なるか?

    藤原 智洋, 中田 英二, 堅山 佳美, 濱田 全紀, 国定 俊之, 尾崎 敏文, 千田 益生

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S364 - S364   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 骨盤悪性腫瘍に対するHip transposition法の術後機能・歩行能力

    国定 俊之, 中田 英二, 藤原 智洋, 尾崎 敏文, 堅山 佳美, 濱田 全紀, 千田 益生

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S364 - S364   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 60歳以上の術前がん患者のがんロコモとサルコペニア,フレイルの有病率

    堅山 佳美, 中田 英二, 藤原 智洋, 國定 俊之, 濱田 全紀, 千田 益生, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S363 - S363   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 踵骨関節内骨折の固定法の変化と術後荷重開始時期の短縮

    依光 正則, 上原 健敬, 佐藤 浩平, 福岡 史朗, 濱田 全紀, 千田 益生, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S353 - S353   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 大腿骨頸部骨折を合併した寛骨臼両柱骨折の1例

    福岡 史朗, 依光 正則, 畑 利彰, 佐藤 浩平, 上原 健敬, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   417 - 417   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 踵骨関節内骨折に対する低侵襲ロッキングプレート固定は早期荷重を可能とさせる

    國富 康資, 依光 正則, 上原 健敬, 福岡 史朗, 佐藤 浩平, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   65 ( 秋季学会 )   194 - 194   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • 岡山大学病院における頸椎損傷の急性期手術介入のタイミングに関する検討

    魚谷 弘二, 植田 昌敬, 志渡澤 央和, 小田 孔明, 鉄永 倫子, 三澤 治夫, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 3 )   437 - 437   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 生理的インピーダンス法におけるPhase angleは運動器慢性疼痛患者においてサルコペニア検出に有用である

    辻 寛謙, 三澤 治夫, 鉄永 智紀, 濱田 全紀, 堅山 佳美, 小田 孔明, 西田 圭一朗, 千田 益生, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S343 - S343   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • ポータブル筋音筋電計を用いた膝蓋腱反射の定量化

    辻 寛謙, 三澤 治夫, 小田 孔明, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S392 - S392   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • Factors influencing caregiver burden in chronic pain patients: A retrospective study 国際誌

    Hironori Tsuji, Tomoko Tetsunaga, Tomonori Tetsunaga, Haruo Misawa, Yoshiaki Oda, Shinichiro Takao, Keiichiro Nishida, Toshifumi Ozaki

    Medicine   101 ( 39 )   e30802 - e30802   2022年9月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    Chronic pain coexists with disability, anxiety, depression, and sleep disturbances, which are factors of pain chronicity in the fear-avoidance model. Self-efficacy for managing pain plays a protective role against pain chronicity. For chronic pain sufferers, social support from caregivers is important. However, such caregivers face enormous physical and mental burdens. This study aimed to assess how self-efficacy and factors related to the fear-avoidance model affect caregiver burden. Participants were 135 chronic pain patients and their caregivers who visited our outpatient pain special clinic. In clinical assessments, numeric rating scale (NRS), pain catastrophizing scale (PCS), hospital anxiety and depression scale (HADS), Athens insomnia scale (AIS), pain disability assessment scale (PDAS), pain self-efficacy questionnaire (PSEQ) for the patients and Zarit Burden Interview (ZBI) for their caregivers were evaluated. Participants were divided into 2 groups (L group ZBI < 24 points and H group ZBI ≥ 24 points) and compared. Regression analyses were conducted to identify factors correlated with the ZBI scores. Compared to L group, H group showed significantly higher NRS and HADs depression scores, and lower PSEQ scores. In univariate regression analysis, ZBI scores were significantly correlated with NRS, PCS, HADS anxiety, HADS depression, PDAS and PSEQ. Multiple linear regression analysis revealed that ZBI scores were significantly correlated with PSEQ. The caregivers who perceived high caregiver burden had significantly higher patients' pain intensity, depression, and lower self-efficacy than those who perceived low caregiver burden. Caregiver burden correlated with the pain intensity, pain catastrophizing, anxiety, depression, disability, and self-efficacy of chronic pain patients. Among these factors, self-efficacy was the most negatively correlated with caregiver burden. Treatments focused on increasing self-efficacy for managing pain have the potential to reduce caregiver burden.

    DOI: 10.1097/md.0000000000030802

    PubMed

    researchmap

  • DevOpsを用いた機械学習・医療アプリケーションの開発効率の改善

    中原 龍一, 西田 圭一郎, 高橋 康, 那須 義久, 原田 遼三, 堀田 佳史, 浪花 崇一, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1796 - S1796   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Clinicopathological and histological analysis of secondary malignant giant cell tumors of bone without radiotherapy. 国際誌

    Eiji Nakata, Hotaka Kawai, Tomohiro Fujiwara, Toshiyuki Kunisada, Hirofumi Inoue, Mashu Futagawa, Haruyoshi Katayama, Takuto Itano, Toshifumi Ozaki

    Oncology letters   24 ( 3 )   319 - 319   2022年9月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Giant cell tumor of bone (GCTB) is an intermediate bone tumor that rarely undergoes malignant transformation. Secondary malignant GCTB (SMGCTB) is defined as a lesion in which high-grade sarcoma occurs at the site of previously treated GCTB. The present study retrospectively reviewed the medical records of patients with GCTB treated at Okayama University Hospital between April 1986 and April 2020. The clinicopathological and histological features of patients with SMGCTB without prior radiotherapy were investigated. A total of three patients (4%) with SMGCTB were detected, and the tumor sites were the distal ulna, distal femur and sacrum. Two of the patients had been treated with curettage and bone graft, and one had been treated with denosumab. In all cases, the lesions were made up of two components, the conventional GCTB component and the malignant component. The Ki67 labeling index was higher in the malignant components of SMGCTB and metastatic lesions compared with that in primary and recurrent conventional GCTB, or the conventional GCTB component of SMGCTB. Moreover, p53 expression was higher in these same components in patients who underwent curettage and bone grafting; however, there was no difference in the patient that received denosumab treatment. In this patient, clinical cancer genomic profiling revealed loss of CDKN2A, CDKN2B and MTAP expression. All three patients developed distant metastasis. The patients with SMGCTB in the ulna and femur died 13 and 54 months after detection of malignant transformation, respectively. The patient with SMGCTB in the sacrum received carbon-ion radiotherapy to the sacrum and pazopanib; the treatment was effective and the patient was alive at the last follow-up 3 years later. In conclusion, p53 may be associated with malignant transformation in GCTB. Future studies should investigate the association of between denosumab treatment and malignant transformation, as well as molecular targeted therapy to improve the clinical outcomes of SMGCTB.

    DOI: 10.3892/ol.2022.13439

    PubMed

    researchmap

  • 骨・軟部腫瘍の基礎科学のトピックス クリニカルシークエンスによる肉腫のゲノム医療

    中田 英二, 藤原 智洋, 国定 俊之, 二川 摩周, 遠西 大輔, 久保 寿夫, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1533 - S1533   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨・軟部肉腫に対するがんゲノムプロファイリング検査から検出されるpresumed germline pathogenic variantsの意義

    二川 摩周, 中田 英二, 十川 麗美, 加藤 芙美乃, 浦川 優作, 河内 麻里子, 山本 英喜, 藤原 智洋, 国定 俊之, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1770 - S1770   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • The stability of repaired meniscal root can affect postoperative cartilage status following medial meniscus posterior root repair

    Ximing Zhang, Takayuki Furumatsu, Takaaki Hiranaka, Yuki Okazaki, Haowei Xue, Keisuke Kintaka, Shinichi Miyazawa, Toshifumi Ozaki

    Journal of Orthopaedic Science   2022年9月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.jos.2022.08.005

    researchmap

  • 腫瘍随伴マクロファージの浸潤割合および予後を予測する血中バイオマーカーの特定 浸潤性軟部肉腫患者における検討

    畑 利彰, 藤原 智洋, 吉田 晶, 近藤 彩奈, 近藤 宏也, 佐藤 浩平, たき平 将太, 中田 英二, 国定 俊之, 箱崎 道之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1766 - S1766   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 浸潤型軟部肉腫におけるCathepsin Proteaseの発現の臨床病理学的意義(Clinicopathological significance of cathepsin protease expression in infiltrative soft-tissue sarcomas)

    藤原 智洋, Zhang Lingxin, Chandler Andrew, Yakoub Mohamed, Hameed Meera, 中田 英二, 国定 俊之, 尾崎 敏文, Healey John

    日本癌学会総会記事   81回   P - 1275   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • 浸潤性軟部肉腫患者における腫瘍随伴マクロファージの浸潤および予後を予測する血中バイオマーカーの特定(Circulating cytokines as blood biomarker predictive of TAM infiltration and prognosis in patients with infiltrative STS)

    畑 利彰, 藤原 智洋, 吉田 晶, 近藤 彩奈, 近藤 宏也, 国定 俊之, 尾崎 敏文

    日本癌学会総会記事   81回   J - 1065   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • 変形性股関節症とCCN3発現の相関

    廣瀬 一樹, 中田 英二, 鉄永 智紀, 山田 和希, 佐藤 嘉洋, 小浦 卓, 服部 高子, 桑原 実穂, 滝川 正春, 久保田 聡, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1583 - S1583   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 転移性骨肉腫細胞はCCL2によるM2マクロファージの腫瘍内浸潤を誘導して肺転移を促進する(Metastatic osteosarcoma cells facilitate lung metastasis by inducing CCL2-mediated tumor infiltration of M2 macrophages)

    近藤 宏也, 田澤 大, 久禮 美穂, 藤原 智洋, 国定 俊之, 尾崎 敏文, 藤原 俊義

    日本癌学会総会記事   81回   J - 2087   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • がんゲノム医療において遺伝性骨・軟部肉腫を同定する臨床的意義(Clinical significance of identifying hereditary bone and soft tissue sarcomas in precision medicine)

    二川 摩周, 中田 英二, 十川 麗美, 加藤 芙美乃, 浦川 優作, 植野 さやか, 山本 英喜, 藤原 智洋, 国定 俊之, 尾崎 敏文, 平沢 晃

    日本癌学会総会記事   81回   P - 3121   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • AIと診断・治療 AIによる骨肉腫X線読影システムの偽陽性対策

    長谷井 嬢, 中原 龍一, 藤原 智洋, 中田 英二, 国定 俊之, 木浪 陽, 藤原 一夫, 臼井 正明, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1741 - S1741   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 悪性末梢神経鞘腫瘍におけるPRRX1の悪性化因子としての役割

    たき平 将太, 山田 大祐, 高尾 知佳, 中田 英二, 近藤 宏也, 佐藤 浩平, 畑 利彰, 藤原 智洋, 国定 俊之, 尾崎 敏文, 宝田 剛志

    日本整形外科学会雑誌   96 ( 8 )   S1768 - S1768   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 悪性軟部腫瘍に対する抗CSF-1R阻害薬の有効性 抗腫瘍効果と微小環境へ与える影響(Antitumor effect of CSF-1/CSF-1R blockade in soft-tissue sarcomas)

    近藤 彩奈, 藤原 智洋, 吉田 晶, 畑 利彰, 近藤 宏也, 国定 俊之, 尾崎 敏文

    日本癌学会総会記事   81回   J - 1062   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • Cathepsin proteaseは浸潤型軟部肉腫における浸潤性発育および生存予後に相関する

    藤原 智洋, Zhang Lingxin, Chandler Andrew, Yakoub Mohamed, 中田 英二, 国定 俊之, 尾崎 敏文, Hameed Meera, Healey John

    日本整形外科学会雑誌   96 ( 8 )   S1769 - S1769   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 軟部肉腫に対する抗CSF-1R阻害薬の有効性 抗腫瘍効果と微小環境へ与える影響

    近藤 彩奈, 藤原 智洋, 吉田 晶, 畑 利彰, 近藤 宏也, 片山 晴喜, 佐藤 浩平, たき平 将太, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1765 - S1765   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨・軟部腫瘍の基礎科学のトピックス 転移性骨肉腫は臓器指向性サイトカインの分泌を介して微小環境を変化させ前転移ニッチを形成する

    近藤 宏也, 田澤 大, 藤原 智洋, 近藤 彩奈, 片山 晴喜, 佐藤 浩平, 畑 利彰, 中田 英二, 国定 俊之, 藤原 俊義, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1532 - S1532   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • MPNSTの癌幹細胞性維持に対する腫瘍内のアドレナリン合成酵素の役割

    片山 晴喜, 藤村 篤史, 中田 英二, 大谷 悠介, 藤原 智洋, 国定 俊之, 神谷 厚範, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1768 - S1768   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • ヒトiPS細胞来肢芽間葉系細胞を用いた硝子軟骨シートの作製

    高尾 知佳, 佐藤 正人, 豊田 恵利子, 山田 大祐, 中田 英二, 尾崎 敏文, 宝田 剛志

    日本整形外科学会雑誌   96 ( 8 )   S1557 - S1557   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 大腿骨延長後骨折の変形治癒に対して3次元骨切り術を施行した片側肥大の1例

    山田 和希, 鉄永 智紀, 佐藤 嘉洋, 廣瀬 一樹, 小浦 卓, 井上 智博, 尾崎 敏文, 赤澤 啓史, 青木 清, 寺本 亜留美, 田中 千晴

    中国・四国整形外科学会雑誌   34 ( 2 )   325 - 325   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 当院におけるAR Hip Navigation Systemを用いたカップ設置の精度の検討

    小浦 卓, 鉄永 智紀, 山田 和希, 佐藤 嘉洋, 廣瀬 一樹, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1711 - S1711   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • がんゲノム医療において遺伝性骨・軟部肉腫を同定する臨床的意義(Clinical significance of identifying hereditary bone and soft tissue sarcomas in precision medicine)

    二川 摩周, 中田 英二, 十川 麗美, 加藤 芙美乃, 浦川 優作, 植野 さやか, 山本 英喜, 藤原 智洋, 国定 俊之, 尾崎 敏文, 平沢 晃

    日本癌学会総会記事   81回   P - 3121   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • 骨・軟部肉腫に対するがんゲノムプロファイリング検査から検出されるpresumed germline pathogenic variantsの意義

    二川 摩周, 中田 英二, 十川 麗美, 加藤 芙美乃, 浦川 優作, 河内 麻里子, 山本 英喜, 藤原 智洋, 国定 俊之, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1770 - S1770   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨・軟部腫瘍の基礎科学のトピックス クリニカルシークエンスによる肉腫のゲノム医療

    中田 英二, 藤原 智洋, 国定 俊之, 二川 摩周, 遠西 大輔, 久保 寿夫, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1533 - S1533   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 両側の人工肘関節置換術術後に異所性骨化を生じた1例

    志水 紀之, 浪花 崇一, 堀田 佳史, 中原 龍一, 那須 義久, 西田 圭一郎, 尾崎 敏文

    日本関節病学会誌   41 ( 3 )   165 - 165   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本関節病学会  

    researchmap

  • DevOpsを用いた機械学習・医療アプリケーションの開発効率の改善

    中原 龍一, 西田 圭一郎, 高橋 康, 那須 義久, 原田 遼三, 堀田 佳史, 浪花 崇一, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1796 - S1796   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 関節リウマチにおけるMCP人工指関節再置換術の短期成績

    浪花 崇一, 堀田 佳史, 志水 紀之, 中原 龍一, 那須 義久, 尾崎 敏文, 西田 圭一郎

    日本関節病学会誌   41 ( 3 )   167 - 167   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本関節病学会  

    researchmap

  • ヒトiPS細胞来肢芽間葉系細胞を用いた硝子軟骨シートの作製

    高尾 知佳, 佐藤 正人, 豊田 恵利子, 山田 大祐, 中田 英二, 尾崎 敏文, 宝田 剛志

    日本整形外科学会雑誌   96 ( 8 )   S1557 - S1557   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨・軟部腫瘍の基礎科学のトピックス 転移性骨肉腫は臓器指向性サイトカインの分泌を介して微小環境を変化させ前転移ニッチを形成する

    近藤 宏也, 田澤 大, 藤原 智洋, 近藤 彩奈, 片山 晴喜, 佐藤 浩平, 畑 利彰, 中田 英二, 国定 俊之, 藤原 俊義, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1532 - S1532   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 転移性骨肉腫細胞はCCL2によるM2マクロファージの腫瘍内浸潤を誘導して肺転移を促進する(Metastatic osteosarcoma cells facilitate lung metastasis by inducing CCL2-mediated tumor infiltration of M2 macrophages)

    近藤 宏也, 田澤 大, 久禮 美穂, 藤原 智洋, 国定 俊之, 尾崎 敏文, 藤原 俊義

    日本癌学会総会記事   81回   J - 2087   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • 悪性軟部腫瘍に対する抗CSF-1R阻害薬の有効性 抗腫瘍効果と微小環境へ与える影響(Antitumor effect of CSF-1/CSF-1R blockade in soft-tissue sarcomas)

    近藤 彩奈, 藤原 智洋, 吉田 晶, 畑 利彰, 近藤 宏也, 国定 俊之, 尾崎 敏文

    日本癌学会総会記事   81回   J - 1062   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • 軟部肉腫に対する抗CSF-1R阻害薬の有効性 抗腫瘍効果と微小環境へ与える影響

    近藤 彩奈, 藤原 智洋, 吉田 晶, 畑 利彰, 近藤 宏也, 片山 晴喜, 佐藤 浩平, たき平 将太, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1765 - S1765   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Cathepsin proteaseは浸潤型軟部肉腫における浸潤性発育および生存予後に相関する

    藤原 智洋, Zhang Lingxin, Chandler Andrew, Yakoub Mohamed, 中田 英二, 国定 俊之, 尾崎 敏文, Hameed Meera, Healey John

    日本整形外科学会雑誌   96 ( 8 )   S1769 - S1769   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 悪性末梢神経鞘腫瘍におけるPRRX1の悪性化因子としての役割

    たき平 将太, 山田 大祐, 高尾 知佳, 中田 英二, 近藤 宏也, 佐藤 浩平, 畑 利彰, 藤原 智洋, 国定 俊之, 尾崎 敏文, 宝田 剛志

    日本整形外科学会雑誌   96 ( 8 )   S1768 - S1768   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • MPNSTの癌幹細胞性維持に対する腫瘍内のアドレナリン合成酵素の役割

    片山 晴喜, 藤村 篤史, 中田 英二, 大谷 悠介, 藤原 智洋, 国定 俊之, 神谷 厚範, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1768 - S1768   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • AIと診断・治療 AIによる骨肉腫X線読影システムの偽陽性対策

    長谷井 嬢, 中原 龍一, 藤原 智洋, 中田 英二, 国定 俊之, 木浪 陽, 藤原 一夫, 臼井 正明, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1741 - S1741   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 浸潤型軟部肉腫におけるCathepsin Proteaseの発現の臨床病理学的意義(Clinicopathological significance of cathepsin protease expression in infiltrative soft-tissue sarcomas)

    藤原 智洋, Zhang Lingxin, Chandler Andrew, Yakoub Mohamed, Hameed Meera, 中田 英二, 国定 俊之, 尾崎 敏文, Healey John

    日本癌学会総会記事   81回   P - 1275   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • 浸潤性軟部肉腫患者における腫瘍随伴マクロファージの浸潤および予後を予測する血中バイオマーカーの特定(Circulating cytokines as blood biomarker predictive of TAM infiltration and prognosis in patients with infiltrative STS)

    畑 利彰, 藤原 智洋, 吉田 晶, 近藤 彩奈, 近藤 宏也, 国定 俊之, 尾崎 敏文

    日本癌学会総会記事   81回   J - 1065   2022年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • 腫瘍随伴マクロファージの浸潤割合および予後を予測する血中バイオマーカーの特定 浸潤性軟部肉腫患者における検討

    畑 利彰, 藤原 智洋, 吉田 晶, 近藤 彩奈, 近藤 宏也, 佐藤 浩平, たき平 将太, 中田 英二, 国定 俊之, 箱崎 道之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 8 )   S1766 - S1766   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 脛骨プラトー・骨幹部合併骨折3例の治療経験

    福岡 史朗, 依光 正則, 近藤 宏也, 佐藤 浩平, 畑 利彰, 上原 健敬, 尾崎 敏文

    中国・四国整形外科学会雑誌   34 ( 2 )   287 - 290   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    症例1は86歳女で、プラトー骨折のAO/OTA分類は41B2.1.、骨幹部骨折は42A3であった。治療方法は外側プレートと髄内釘を用いて固定した。症例2は74歳男で、プラトー骨折のAO/OTA分類は41C1.1.、骨幹部骨折は42A1で、治療方法はダブルプレート固定を行った。症例3は67歳女で、プラトー骨折は41B1.1.、骨幹部骨折は42B1で、スクリューと髄内釘による固定を計画したが、術中に髄内釘挿入部近傍の骨折が顕在化し、整復位の保持が困難となったためダブルプレート固定に変更した。3例とも骨癒合が得られた。

    researchmap

    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J02438&link_issn=&doc_id=20221011120020&doc_link_id=%2Fcm4ortho%2F2022%2F003402%2F020%2F0287-0290%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcm4ortho%2F2022%2F003402%2F020%2F0287-0290%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 内側楔状骨背側脱臼骨折の1例

    福岡 史朗, 依光 正則, 佐藤 浩平, 上原 健敬, 野田 知之, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   65 ( 5 )   705 - 706   2022年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    Tarsometatarsal joint(TMT関節)損傷例の中で、内側楔状骨の脱臼を伴った症例は極めて稀である。今回、内側楔状骨の背側脱臼骨折を伴ったTMT関節損傷の1例を経験した。症例は14歳女性で、自動車のタイヤが左足部を轢過して受傷した。手術では、脱臼した楔状骨を含めて内側カラムを再建するために、舟状骨から中足骨まで架橋する強固なプレート固定を行い、術後に損傷部の再転位は認めなかったが、術後徐々に外反母趾が進行した。その原因として、内側カラムの整復不良による第1中足骨の内反(M1-M2角の開大)が残存したことと、内側の軟部組織損傷による不安定性が残存したことが考えられた。

    researchmap

    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00831&link_issn=&doc_id=20221201050037&doc_link_id=10.11359%2Fchubu.2022.705&url=https%3A%2F%2Fdoi.org%2F10.11359%2Fchubu.2022.705&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

  • Transtibial Pullout Repair of Lateral Meniscus Posterior Root Tear with Tissue Loss: A Case with Anterior Cruciate Ligament Injury and Medial Meniscus Tear

    Masanori Tamura, Takayuki Furumatsu, Takaaki Hiranaka, Keisuke Kintaka, Naohiro Higashihara, Yusuke Kamatsuki, Eiji Nakata, Toshifumi Ozaki

    Case Reports in Orthopedics   2022   1 - 8   2022年8月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Hindawi Limited  

    Lateral meniscus (LM) posterior root tear (LMPRT) is mainly caused by trauma, especially trauma associated with anterior cruciate ligament (ACL) injuries. Although a transtibial pullout repair or a side-to-side repair is commonly performed for LMPRT, to the best of our knowledge, there is no clinical report of LMPRT with tissue loss using the pullout technique. Thus, the purpose of this report was to describe a clinical, radiographic, and arthroscopic outcome after pullout repair for a case of LMPRT with a large defect with a chronic ACL tear and complex medial meniscus (MM) tears. A 31-year-old man complained of knee pain and restricted range of motion after twisting his knee when he stepped on an iron pipe. The patient had a football-related injury to his right knee 14 years before presentation, and since then, the patient’s knee has given out more than 10 times but was left unassessed. Magnetic resonance imaging showed LMPRT with tissue loss, ACL tears, and complex MM tears. Transtibial pullout repair of the LMPRT with ACL reconstruction and MM repairs were performed. Following the pullout repair of the LMPRT, an approximately 6 mm gap remained between the LM posterior root and root insertion. However, magnetic resonance imaging and second-look arthroscopy at 1 year postoperatively revealed meniscal healing, gap filling with some regeneration tissue, of the LM posterior root. Furthermore, the lateral meniscus extrusion in the coronal plane improved from 3.1 mm (preoperative) to 1.6 mm (1 year postoperatively). Transtibial pullout repair with the remaining gap could be a viable treatment option for LMPRT with tissue loss, combined with ACL reconstruction.

    DOI: 10.1155/2022/9776388

    researchmap

    その他リンク: http://downloads.hindawi.com/journals/crior/2022/9776388.xml

  • Association between Immediate Postoperative Radiographic Findings and Failed Internal Fixation for Trochanteric Fractures: Systematic Review and Meta-Analysis. 国際誌

    Norio Yamamoto, Yasushi Tsujimoto, Suguru Yokoo, Koji Demiya, Madoka Inoue, Tomoyuki Noda, Toshifumi Ozaki, Takashi Yorifuji

    Journal of clinical medicine   11 ( 16 )   2022年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Failed internal fixations for trochanteric fractures have a strong negative impact owing to increased postoperative mortality and high medical costs. However, evidence on the prognostic value of postoperative radiographic findings for failed internal fixations is limited. We aimed to clarify the association between comprehensive immediate postoperative radiographic findings and failed internal fixation using relative and absolute risk measures. We followed the meta-analysis of observational studies in epidemiology guidelines and the Cochrane handbook. We searched specific databases in November 2021. The outcomes of interest were failed internal fixation and cut-out. We pooled the odds ratios and 95% confidence intervals using a random-effects model and calculated the number needed to harm for each outcome. Thirty-six studies involving 8938 patients were included. The certainty of evidence in the association between postoperative radiographic findings and failed internal fixation or cut-out was mainly low or very low except for the association between intramedullary malreduction on the anteromedial cortex and failed internal fixation. Moderate certainty of evidence supported that intramedullary malreduction on the anteromedial cortex was associated with failed internal fixation. Most postoperative radiographic findings on immediate postoperative radiographs for trochanteric fractures were uncertain as prognostic factors for failed internal fixations.

    DOI: 10.3390/jcm11164879

    PubMed

    researchmap

  • Steep posterior slope of the medial tibial plateau and anterior cruciate ligament degeneration contribute to medial meniscus posterior root tears in young patients. 国際誌

    Yuya Kodama, Takayuki Furumatsu, Masanori Tamura, Yuki Okazaki, Takaaki Hiranaka, Yusuke Kamatsuki, Toshifumi Ozaki

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA   2022年8月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Medial meniscus posterior root tears (MMPRTs) occur most frequently in middle-aged and older adults. However, this serious condition can also occur in younger patients. The purpose of this study was to compare anterior cruciate ligament (ACL) degeneration and sagittal medial tibial slope in young adults with and without MMPRT. METHODS: Eighteen healthy volunteers, 18 young patients (20-49 years of age), and 30 middle-aged and older patients (50-70 years of age) with MMPRT repair were included in the study. Sex, body mass index (BMI), femorotibial angle, ACL degeneration, and medial tibial slope angle were compared among the groups. ACL degeneration and medial tibial slope angle were assessed using magnetic resonance imaging. RESULTS: In the healthy volunteer group, the young patient group, and the older patient group, the medial tibial slopes were 3.5° ± 1.4°, 6.1° ± 2.7°, and 7.2° ± 1.9°, respectively, and the ACL degeneration rates were 5.6%, 38.9%, and 43.3%, respectively. Young patients with MMPRT had significantly steeper medial tibial slopes and ACL degeneration compared to those of the healthy volunteers (P < 0.05). The parameters of young patients were similar to those of older patients with MMPRT. In the multivariate logistic regression analysis, BMI, medial tibial slope, and ACL degeneration were significantly associated with MMPRT in young patients. CONCLUSION: BMI, steep medial tibial slope, and ACL degeneration contribute to MMPRT development in younger patients. LEVEL OF EVIDENCE: Level III.

    DOI: 10.1007/s00167-022-07095-z

    PubMed

    researchmap

  • Coronal shear fractures of the femoral neck: a comparison with basicervical fractures

    Yasuaki Yamakawa, Norio Yamamoto, Yosuke Tomita, Tomoyuki Noda, Tomoo Inoue, Toshiyuki Matsumoto, Keisuke Kawasaki, Toshifumi Ozaki

    European Journal of Trauma and Emergency Surgery   2022年8月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s00068-022-02079-7

    researchmap

    その他リンク: https://link.springer.com/article/10.1007/s00068-022-02079-7/fulltext.html

  • Effect of bacterium in the malignant wounds of soft tissue sarcoma 国際誌

    Eiji Nakata, Tomohiro Fujiwara, Haruyoshi Katayama, Takuto Itano, Toshiyuki Kunisada, Toshifumi Ozaki

    Oncology Letters   24 ( 4 )   345 - 345   2022年8月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Spandidos Publications  

    Malignant wounds (MWs) are rare skin lesions, which accompany ulceration, necrosis and infection caused by infiltration or damage by malignant tumor. The present study aimed to investigate the bacterial etiology implicated in MW in soft tissue sarcoma (STS), and the effectiveness of culture-guided perioperative antibacterial administration. A retrospective evaluation was conducted on medical records of patients who presented with MW between 2006 and 2020. A total of seven patients were included in the present study, in whom all tumors were relatively large (>5 cm) and high-grade. Subsequently, five patients underwent limb-sparing surgery, and three patients had distant metastases with a 5-year overall survival of 71%. Preoperative microbiological sampling from the wound identified 11 different bacterial strains in five patients. The infections were polymicrobial with an average of 2.6 strains isolated per patient (1 aerobic, 1.6 anaerobic bacteria). They were predominantly methicillin-sensitive Staphylococcus aureus. Patients with MWs from STS reported symptoms, including bleeding (71%), exudation (71%) and malodorous wound (43%) at the initial presentation; these completely resolved after surgery. All but one patient reported pain at the MW site with an average numeric rating scale of 4.4 at presentation that decreased to 1.4 (P=0.14) and 0.6 (P=0.04) one and two weeks after surgery, respectively. The patients had elevated C-reactive protein (71%), anemia (57%), low albumin (86%) and renal/liver dysfunction (14-29%). One patient was diagnosed with sepsis. Surgical resection afforded symptomatic relief and resolution of abnormal laboratory values. Although selected antibiotics were administered in four patients based on the preoperative antibiotic sensitivity test, surgical site infection (SSI) occurred in three patients. Therefore, the effectiveness of the selected antibiotics based on the results of the preoperative culture in preventing SSI needs to be investigated in the future. In conclusion, physicians should keep in mind that although surgical resection can improve the symptoms and abnormal values in laboratory examination form MW, it is accompanied with a high rate of SSI and poor prognosis.

    DOI: 10.3892/ol.2022.13465

    PubMed

    researchmap

  • Alveolar soft part sarcoma: progress toward improvement in survival? A population-based study. 国際誌

    Tomohiro Fujiwara, Eiji Nakata, Toshiyuki Kunisada, Toshifumi Ozaki, Akira Kawai

    BMC cancer   22 ( 1 )   891 - 891   2022年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare histological subtype of soft-tissue sarcoma, which remains refractory to conventional cytotoxic chemotherapy. We aimed to characterize ASPS and investigate whether the oncological outcome has improved over the past decade. METHODS: One hundred and twenty patients with newly diagnosed ASPS from 2006 to 2017, identified from the Bone and Soft-Tissue Tumor Registry in Japan, were analyzed retrospectively. RESULTS: The study cohort comprised 34 (28%) patients with localized ASPS and 86 (72%) with metastatic disease at presentation. The 5-year disease-specific survival (DSS) was 68% for all patients and 86% and 62% for localized and metastatic disease, respectively (p = 0.019). Metastasis at presentation was the only adverse prognostic factor for DSS (hazard ratio [HR]: 7.65; p = 0.048). Patients who were > 25 years (80%; p = 0.023), had deep-seated tumors (75%; p = 0.002), and tumors > 5 cm (5-10 cm, 81%; > 10 cm, 81%; p < 0.001) were more likely to have metastases at presentation. In patients with localized ASPS, adjuvant chemotherapy or radiotherapy did not affect survival, and 13 patients (45%) developed distant metastases in the lung (n = 12, 92%) and brain (n = 2, 15%). In patients with metastatic ASPS (lung, n = 85 [99%]; bone, n = 12 [14%]; and brain n = 9 [11%]), surgery for the primary or metastatic site did not affect survival. Prolonged survival was seen in patients who received pazopanib treatment (p = 0.045), but not in those who received doxorubicin-based cytotoxic chemotherapy. Overall, improved DSS for metastatic ASPS has been observed since 2012 (5-year DSS, from 58 to 65%) when pazopanib was approved for advanced diseases, although without a statistically significant difference (p = 0.117). CONCLUSION: The national study confirmed a unique feature of ASPS with frequent metastasis to the lung and brain but an indolent clinical course. An overall trend toward prolonged survival after the introduction of targeted therapy encourages continuous efforts to develop novel therapeutic options for this therapeutically resistant soft-tissue sarcoma.

    DOI: 10.1186/s12885-022-09968-5

    PubMed

    researchmap

    その他リンク: https://link.springer.com/article/10.1186/s12885-022-09968-5/fulltext.html

  • Risk Factors for Infection Following Operative Treatment of Traumatic Upper Extremity Amputation Injury. 国際誌

    Taichi Saito, Takenori Uehara, Ryuichi Nakahara, Yasunori Shimamura, Atsunori Nakao, Toshifumi Ozaki

    The journal of hand surgery Asian-Pacific volume   27 ( 4 )   691 - 697   2022年8月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Identification of the risk factors for surgical site infection (SSI) can be a straightforward and cost-effective measure to reduce or prevent the occurrence of SSI. However, there are no studies that revealed risk factors for SSI for traumatic upper extremity amputation. The aim of this study is to investigate the risk factors that promote SSI after surgery for traumatic upper extremity amputation using a large nationwide database. Methods: We used data from the Japan Trauma Data Bank. Diagnoses were defined using the Abbreviated Injury Scale code. We applied multivariate logistic regression to evaluate the infection risk factor. We chose age, sex, vital signs, cause and type of trauma, concomitant injury, diabetes, amputation level, Glasgow coma scale, Injury Severity Score (ISS) and blood transfusion within 24 hours following hospital arrival as confounders. Receiver operating characteristic (ROC) curve analysis was adopted to identify thresholds for change in infection risk. We also applied propensity score (PS) matching to adjust for confounding factors that may affect the outcome. Results: A total of 1,150 patients (967 males, 183 females) had traumatic upper extremity amputation. The mean patient age was 46.5 years. A total of 21 patients (1.8%) suffered from SSI. ISS, blood transfusion, systolic blood pressure (BP) and the upper extremity amputation except for finger were identified as the independent significant risk factors for SSI occurrence by the multivariate analysis (p < 0.05, p < 0.005, p < 0.05 and p < 0.005, respectively). ROC modelling revealed that patients with ISS of over 9 or systolic BP of over 160 had a risk for SSI. After PS matching, the patients with blood transfusion or systolic BP of over 160 had a significantly higher risk of infection (OR 9.0; p = 0.01 and OR 7.0; p = 0.03, respectively). Conclusions: In treating patients with these risk factors, we must be especially careful in performing thorough debridement and wound care. Level of Evidence: Level II (Therapeutic).

    DOI: 10.1142/S2424835522500709

    PubMed

    researchmap

  • Late-onset implant-related neuropathy: Three years after proximal humeral fracture. 国際誌

    Yasuaki Yamakawa, Yusuke Kamatsuki, Toshiyuki Matsumoto, Tomoyuki Noda, Toshifumi Ozaki

    Trauma case reports   40   100670 - 100670   2022年8月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    There are currently no reports of implant-related neuropathy associated with humeral proximal fracture surgery. Herein, we report a case of implant-related late-onset neuropathy that developed 3 years after proximal humeral fracture surgery. A 51-year-old man underwent minimally invasive plate osteosynthesis for a left proximal humeral fracture 3 years prior. Left upper limb pain and reduced angle of elevation of the shoulder were recognized 1 month before the outpatient consultation. Numbness was noted on the ulnar side of the hand, and radiating pain to the ulnar nerve region was noted during shoulder abduction and compression of the medial side of the upper arm. Computed tomography revealed close proximity of the neurovascular bundle to the locking screw along with muscle atrophy around the shoulder. Hence, the patient was diagnosed with neuropathy. After implant removal, the pain in the ulnar nerve region improved, and the upper arm could be elevated. In our case, the cause of muscle atrophy was axillary nerve manipulation and cervical myelopathy caused by the operation. When late-onset neuropathy occurs, implant-related neuropathy with muscle atrophy should be considered.

    DOI: 10.1016/j.tcr.2022.100670

    PubMed

    researchmap

  • Perioperative Adriamycin plus ifosfamide vs. gemcitabine plus docetaxel for high-risk soft tissue sarcomas: randomised, phase II/III study JCOG1306. 国際誌

    Kazuhiro Tanaka, Ryunosuke Machida, Akira Kawai, Robert Nakayama, Satoshi Tsukushi, Kunihiro Asanuma, Yoshihiro Matsumoto, Hiroaki Hiraga, Koji Hiraoka, Munenori Watanuki, Tsukasa Yonemoto, Satoshi Abe, Hirohisa Katagiri, Yoshihiro Nishida, Akihito Nagano, Yoshiyuki Suehara, Hiroyuki Kawashima, Masanori Kawano, Takeshi Morii, Hiroshi Hatano, Junya Toguchida, Tomotake Okuma, Masanobu Takeyama, Satoshi Takenaka, Toshihiro Akisue, Taisuke Furuta, Makoto Emori, Toru Hiruma, Hidetatsu Outani, Tetsuji Yamamoto, Tomoko Kataoka, Haruhiko Fukuda, Toshifumi Ozaki, Yukihide Iwamoto

    British journal of cancer   127 ( 8 )   1487 - 1496   2022年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: This randomised phase II/III trial aimed to determine whether perioperative chemotherapy with gemcitabine plus docetaxel (GD) is non-inferior to the standard Adriamycin plus ifosfamide (AI) in terms of overall survival (OS) in patients with soft tissue sarcoma (STS). METHODS: Patients with localised high-risk STS in the extremities or trunk were randomised to receive AI or GD. The treatments were repeated for three preoperative and two postoperative courses. The primary endpoint was OS. RESULTS: Among 143 enrolled patients who received AI (70 patients) compared to GD (73 patients), the estimated 3-year OS was 91.4% for AI and 79.2% for GD (hazard ratio 2.55, 95% confidence interval: 0.80-8.14, P = 0.78), exceeding the prespecified non-inferiority margin in the second interim analysis. The estimated 3-year progression-free survival was 79.1% for AI and 59.1% for GD. The most common Grade 3-4 adverse events in the preoperative period were neutropenia (88.4%), anaemia (49.3%), and febrile neutropenia (36.2%) for AI and neutropenia (79.5%) and febrile neutropenia (17.8%) for GD. CONCLUSIONS: Although GD had relatively mild toxicity, the regimen-as administered in this study-should not be considered a standard treatment of perioperative chemotherapy for high-risk STS in the extremities and trunk. CLINICAL TRIAL REGISTRATION: jRCTs031180003.

    DOI: 10.1038/s41416-022-01912-5

    PubMed

    researchmap

  • Evaluation of SARC-F and SARC-CalF for sarcopenia screening in patients with chronic musculoskeletal pain: A prospective cross-sectional study. 国際誌

    Hironori Tsuji, Tomoko Tetsunaga, Tomonori Tetsunaga, Haruo Misawa, Yoshiaki Oda, Shinichiro Takao, Keiichiro Nishida, Toshifumi Ozaki

    Medicine   101 ( 29 )   e29568   2022年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Early sarcopenia detection using screening tools, such as SARC-F and SARC-CalF, has been proven reliable. However, the relationship between chronic musculoskeletal pain with sarcopenia is unknown. This study assessed sarcopenia morbidity as well as the reliability of sarcopenia screening with SARC-F and SARC-CalF in patients with chronic musculoskeletal pain. METHODS: Overall, 172 patients with chronic musculoskeletal pain were included in this cross-sectional study. All participants completed the SARC-F, SARC-CalF, numeric rating scale (NRS), and pain disability assessment scale (PDAS) assessments. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia criteria 2019. Correlations between SARC-F and SARC-CalF scores and each measured variable were evaluated using univariate and multiple linear regression analyses. A receiver operating characteristic curve analysis was conducted, and reliabilities of SARC-F and SARC-CalF scores for diagnosing sarcopenia were compared. RESULTS: Thirty-nine patients were diagnosed with sarcopenia. Among these, 10 patients were <65 years old, and 29 were >65 years old. Both SARC-F and SARC-CalF scores significantly correlated with grip power, gait speed, skeletal mass index, numeric rating scale score, and PDAS score. In multiple linear regression analysis, SALC-F and SALC-CalF scores significantly correlated with PDAS score, skeletal mass index, and gait speed. The area under the curve were 0.70 for SARC-F and 0.88 for SARC-CalF; SARC-CalF had a significantly higher area under the curve than SARC-F. DISCUSSION: Sarcopenia was diagnosed in patients aged <65 years with chronic musculoskeletal pain. SALC-F and SARC-CalF scores showed a significant correlation with disability due to pain and were reliable sarcopenia screening tools for chronic musculoskeletal pain. SARC-CalF was more reliable than SARC-F.

    DOI: 10.1097/MD.0000000000029568

    PubMed

    researchmap

  • Arthroscopic Meniscal Healing following Medial Meniscus Posterior Root Repair: A Comparison between Two Suture Materials. 国際誌

    Yuki Okazaki, Takayuki Furumatsu, Takaaki Hiranaka, Ximing Zhang, Keisuke Kintaka, Naohiro Higashihara, Masanori Tamura, Yuya Kodama, Yusuke Kamatsuki, Toshifumi Ozaki

    The journal of knee surgery   2022年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Recently, transtibial pullout repair of the medial meniscus (MM) posterior root tear (PRT) has become widely accepted and provides satisfactory clinical outcomes. Widening after cyclic loading or ultimate failure load using different suture materials and configurations has been studied. However, no study has compared the clinical outcomes using different suture materials. This study aimed to evaluate the clinical outcomes after performing MMPRT pullout repair using different suture materials. We hypothesized that better clinical outcomes would be achieved using ultra-high molecular weight polyethylene (UHMWPE) tape compared with a normal polyester suture. Thirty-seven patients who underwent MM posterior root repair between November 2019 and May 2020 were retrospectively investigated. Pullout repair was performed using a hollow no. 0 polyester suture (n = 14) and UHMWPE tape (n = 23). Clinical outcomes were assessed preoperatively and at 1 year postoperatively, using the Lysholm knee score, Knee Injury and Osteoarthritis Outcome Score, and visual analogue scale (VAS) pain score. The meniscal healing status was assessed using an arthroscopic scoring system (range: 0-10). All clinical scores were improved significantly in both groups. However, significantly higher meniscal healing scores and decreased VAS pain scores were observed in the UHMWPE group (7.3 ± 0.9 and 7.7 ± 11.3, respectively) than in the polyester group (5.6 ± 2.1 and 18.4 ± 18.6, respectively; p < 0.01). Suture cut-out and loss of the root continuity were observed in some cases (three cases [21.4%] in the polyester suture group and one case [4.3%] in the UHMWPE tape group). Both suture materials led to satisfactory clinical outcomes at 1 year postoperatively, whereas the UHMWPE tape was useful for obtaining good meniscal healing and decreasing the VAS pain score.

    DOI: 10.1055/s-0042-1750047

    PubMed

    researchmap

  • モジュラー型人工関節・骨軟部腫瘍領域感染 腫瘍用人工関節の術後感染

    中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本骨・関節感染症学会プログラム・抄録集   45回   108 - 108   2022年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨・関節感染症学会  

    researchmap

  • 小児化膿性股関節炎に対するα-ディフェンシン検出キットの使用経験

    小浦 卓, 鉄永 智紀, 山田 和希, 佐藤 嘉洋, 廣瀬 一樹, 尾崎 敏文

    日本骨・関節感染症学会プログラム・抄録集   45回   224 - 224   2022年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨・関節感染症学会  

    researchmap

  • Larger sagittal inter-screw distance/tibial width ratio reduces delayed union or non-union after arthroscopic ankle arthrodesis. 国際誌

    Suguru Yokoo, Kenta Saiga, Koji Demiya, Hideki Ohashi, Masahiro Horita, Toshifumi Ozaki

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie   2022年6月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Arthroscopic ankle arthrodesis (AAA) has risks of complications, such as delayed union and non-union. The number and direction of the inserted screws have been reported as important factors affecting the time to union of AAA. However, the ratio of inter-screw distance (ISD) to tibial width (TW) in different planes has not been investigated. Therefore, we aimed to explore the effect of this ratio on bone union following AAA. METHODS: We retrospectively enrolled 63 patients (64 ankles) undergoing AAA from 2013 to 2019. Then, their age, body mass index (BMI), sex, diabetes mellitus (DM) status, Takakura-Tanaka classification, number of screws and radiographic parameters were analysed. RESULTS: The patients had a mean age of 70.3 (range, 45-91) years. Bone fusion was achieved in 57 ankles (89%) in a mean period of 3.3 (range, 2-6) postoperative months. There were four cases of delayed union and three of non-union. No significant differences in age, BMI, sex, DM, Takakura-Tanaka classification, and number of screws could be detected between the groups. However, the sagittal ISD/TW ratio was significantly larger in the union group than in the delayed/non-union group with a cut-off value of 57.0%. CONCLUSION: Larger sagittal ISD/TW ratios result in reduced post-AAA delayed union or non-union. The surgeon should be aware that the anterior and posterior screw widths should be approximately 60% or more of the anteroposterior width of the tibia.

    DOI: 10.1007/s00590-022-03307-x

    PubMed

    researchmap

  • 脛骨プラトー・骨幹部合併骨折の治療経験

    福岡 史朗, 依光 正則, 佐藤 浩平, 畑 利彰, 上原 健敬, 尾崎 敏文

    骨折   44 ( Suppl. )   S285 - S285   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance

    Ryo Nakamichi, Shang Ma, Takayuki Nonoyama, Tomoki Chiba, Ryota Kurimoto, Hiroki Ohzono, Merissa Olmer, Chisa Shukunami, Noriyuki Fuku, Guan Wang, Errol Morrison, Yannis P. Pitsiladis, Toshifumi Ozaki, Darryl D’Lima, Martin Lotz, Ardem Patapoutian, Hiroshi Asahara

    Science Translational Medicine   14 ( 647 )   2022年6月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Association for the Advancement of Science (AAAS)  

    How mechanical stress affects physical performance via tendons is not fully understood. Piezo1 is a mechanosensitive ion channel, and E756del PIEZO1 was recently found as a gain-of-function variant that is common in individuals of African descent. We generated tendon-specific knock-in mice using R2482H Piezo1 , a mouse gain-of-function variant, and found that they had higher jumping abilities and faster running speeds than wild-type or muscle-specific knock-in mice. These phenotypes were associated with enhanced tendon anabolism via an increase in tendon-specific transcription factors, Mohawk and Scleraxis, but there was no evidence of changes in muscle. Biomechanical analysis showed that the tendons of R2482H Piezo1 mice were more compliant and stored more elastic energy, consistent with the enhancement of jumping ability. These phenotypes were replicated in mice with tendon-specific R2482H Piezo1 replacement after tendon maturation, indicating that PIEZO1 could be a target for promoting physical performance by enhancing function in mature tendon. The frequency of E756del PIEZO1 was higher in sprinters than in population-matched nonathletic controls in a small Jamaican cohort, suggesting a similar function in humans. Together, this human and mouse genetic and physiological evidence revealed a critical function of tendons in physical performance, which is tightly and robustly regulated by PIEZO1 in tenocytes.

    DOI: 10.1126/scitranslmed.abj5557

    researchmap

  • 人工知能による骨肉腫X線読影システムの開発と骨端線認識への挑戦

    長谷井 嬢, 中原 龍一, 国定 俊之, 中澤 慎二, 韓 昌煕, 藏品 豊, 木浪 陽, 藤原 一夫, 臼井 正明, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1333 - S1333   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Hip Fractures after Intramedullary Nailing Fixation for Atypical Femoral Fractures: Three Cases.

    Norio Yamamoto, Tomoo Inoue, Yusuke Mochizuki, Tomoyuki Noda, Keisuke Kawasaki, Toshifumi Ozaki

    Acta medica Okayama   76 ( 3 )   317 - 321   2022年6月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(大学,研究機関等紀要)  

    Secondary hip fractures (SHFs) rarely occur after intramedullary nailing (IMN) fixation without femoral neck fixation for atypical femoral fractures (AFFs). We report three cases of older Japanese women who sustained SHFs presumably caused by osteoporosis and peri-implant stress concentration around the femoral neck after undergoing IMN without femoral neck fixation for AFF. All cases were fixed with malalignment. In AFF patients, postoperative changes due to postoperative femoral bone malalignment may affect the peri-implant mechanical environment around the femoral neck, which can result in insufficiency fractures. At the first AFF surgery, we recommend femoral neck fixation after adequate reduction is achieved.

    DOI: 10.18926/AMO/63741

    PubMed

    researchmap

  • 遺伝性骨・軟部腫瘍外来の取り組み

    中田 英二, 藤原 智洋, 国定 俊之, 二川 摩周, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1315 - S1315   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 遺伝性骨・軟部腫瘍に対する遺伝学的検査の臨床的意義

    二川 摩周, 中田 英二, 十川 麗美, 加藤 芙美乃, 浦川 優作, 河内 麻里子, 山本 英喜, 藤原 智洋, 国定 俊之, 尾崎 敏文, 平沢 晃

    日本整形外科学会雑誌   96 ( 6 )   S1301 - S1301   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • ゲノム医療時代の骨・軟部腫瘍医 骨・軟部腫瘍診療におけるがん遺伝子パネルの意義

    中田 英二, 藤原 智洋, 国定 俊之, 二川 摩周, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1286 - S1286   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 高悪性度非円形細胞軟部肉腫における術前化学療法の組織学的効果判定法の標準化と予後的意義 JCOG0304附随研究

    遠藤 誠, 小田 義直, 田仲 和宏, 廣瀬 隆則, 長谷川 匡, 蛭田 啓之, 久岡 正典, 国定 俊之, 比留間 徹, 土屋 弘行, 片桐 浩久, 松本 嘉寛, 川井 章, 中山 ロバート, 川島 寛之, 水澤 純基, 福田 治彦, 尾崎 敏文, 岩本 幸英, 野島 孝之

    日本整形外科学会雑誌   96 ( 6 )   S1423 - S1423   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 観血的治療を行った不安定型骨盤輪損傷の治療成績

    上原 健敬, 依光 正則, 福岡 史朗, 佐藤 浩平, 畑 利彰, 近藤 宏也, 齋藤 太一, 島村 安則, 野田 知之, 尾崎 敏文

    骨折   44 ( Suppl. )   S191 - S191   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 消化器がん患者の術前がんロコモ 年齢別の検討

    堅山 佳美, 中田 英二, 千田 益生, 濱田 全紀, 藤原 智洋, 国定 俊之, 尾崎 敏文

    運動器リハビリテーション   33 ( 2 )   136 - 136   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本運動器科学会  

    researchmap

  • 下肢悪性骨・軟部腫瘍に対する広範切除後の機能回復

    濱田 全紀, 中田 英二, 堅山 佳美, 藤原 智洋, 国定 俊之, 千田 益生, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1433 - S1433   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 消化器がん患者の術前がんロコモ

    堅山 佳美, 中田 英二, 千田 益生, 濱田 全紀, 国定 俊之, 藤原 智洋, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1440 - S1440   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 80歳以上の超高齢軟部肉腫患者の治療における老年学的因子の意義

    近藤 彩奈, 藤原 智洋, 吉田 晶, 片山 晴喜, 畑 利彰, 佐藤 浩平, たき平 将太, 近藤 宏也, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1298 - S1298   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 人工知能による骨肉腫X線読影システムの開発と骨端線認識への挑戦

    長谷井 嬢, 中原 龍一, 国定 俊之, 中澤 慎二, 韓 昌煕, 藏品 豊, 木浪 陽, 藤原 一夫, 臼井 正明, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1333 - S1333   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 遺伝性骨・軟部腫瘍に対する遺伝学的検査の臨床的意義

    二川 摩周, 中田 英二, 十川 麗美, 加藤 芙美乃, 浦川 優作, 河内 麻里子, 山本 英喜, 藤原 智洋, 国定 俊之, 尾崎 敏文, 平沢 晃

    日本整形外科学会雑誌   96 ( 6 )   S1301 - S1301   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • ゲノム医療時代の骨・軟部腫瘍医 骨・軟部腫瘍診療におけるがん遺伝子パネルの意義

    中田 英二, 藤原 智洋, 国定 俊之, 二川 摩周, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1286 - S1286   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 遺伝性骨・軟部腫瘍外来の取り組み

    中田 英二, 藤原 智洋, 国定 俊之, 二川 摩周, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1315 - S1315   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨巨細胞腫に対するデノスマブのde-escalationの有効性

    板野 拓人, 中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1368 - S1368   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 浸潤性軟部肉腫における放射線療法の治療効果の検討

    畑 利彰, 藤原 智洋, 吉田 晶, 近藤 宏也, 近藤 彩奈, 片山 晴喜, 佐藤 浩平, たき平 将太, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1365 - S1365   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 大腿骨近位部転移性骨腫瘍に対する手術療法

    佐藤 浩平, 中田 英二, 片山 晴喜, 近藤 彩奈, 近藤 宏也, 畑 利彰, たき平 将太, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1461 - S1461   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 臓器指向性分泌サイトカイン/細胞外小胞を介したcell-cell communicationによる骨肉腫の新しい肺転移形成機構の同定

    近藤 宏也, 藤原 智洋, 田澤 大, 吉田 晶, 片山 晴喜, 近藤 彩奈, 佐藤 浩平, 畑 利彰, たき平 将太, 中田 英二, 国定 俊之, 藤原 俊義, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1424 - S1424   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 消化器がん患者の術前がんロコモ

    堅山 佳美, 中田 英二, 千田 益生, 濱田 全紀, 国定 俊之, 藤原 智洋, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1440 - S1440   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 下肢悪性骨・軟部腫瘍に対する広範切除後の機能回復

    濱田 全紀, 中田 英二, 堅山 佳美, 藤原 智洋, 国定 俊之, 千田 益生, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1433 - S1433   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • ナビゲーション支援手術は補助療法の効果を期待しにくい骨盤軟骨肉腫の腫瘍学的予後を改善させるか

    藤原 智洋, 金内 洋一, 津田 祐輔, Stevenson Jonathan, Parry Michael, Grimer Robert, Jeys Lee, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1288 - S1288   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • ビッグデータと骨・軟部腫瘍-全国骨軟部腫瘍登録- National Cancer Databaseを利用した骨・軟部腫瘍研究 社会経済的・地理的データから骨・軟部腫瘍診療の実態と課題を読み取る

    藤原 智洋, 小倉 浩一, 中田 英二, 国定 俊之, 尾崎 敏文, 川井 章, Healey John H.

    日本整形外科学会雑誌   96 ( 6 )   S1269 - S1269   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨盤周囲深部発生軟部肉腫の治療成績

    片山 晴喜, 藤原 智洋, 国定 俊之, 中田 英二, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 6 )   S1363 - S1363   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 転移性骨腫瘍(切迫骨折の治療) 大腿骨近位部転移性骨腫瘍に対する手術療法

    佐藤 浩平, 依光 正則, 福岡 史朗, 畑 利彰, 近藤 宏也, 上原 健敬, 中田 英二, 国定 俊之, 野田 知之, 尾崎 敏文

    骨折   44 ( Suppl. )   S70 - S70   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • TKA後に生じた大腿骨非定型骨折の2例

    畑 利彰, 依光 正則, 島村 安則, 上原 健敬, 福岡 史朗, 佐藤 浩平, 近藤 宏也, 野田 知之, 尾崎 敏文

    骨折   44 ( Suppl. )   S249 - S249   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • Complex fractures around the knee 高エネルギー脛骨プラトー骨折(High Energy Tibial Plateau Fracture)

    依光 正則, 上原 健敬, 畑 利彰, 佐藤 浩平, 福岡 史朗, 野田 知之, 尾崎 敏文

    骨折   44 ( Suppl. )   S21 - S21   2022年6月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 脛骨遠位骨幹部骨折に対するSemiextended approachは術後足関節アライメントを悪化させない

    福岡 史朗, 依光 正則, 佐藤 浩平, 畑 利彰, 上原 健敬, 寺田 忠司, 尾崎 敏文

    骨折   44 ( Suppl. )   S292 - S292   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • Medial meniscus posterior root repair influences sagittal length and coronal inclination of the anterior cruciate ligament: a retrospective study. 国際誌

    Yuki Okazaki, Takayuki Furumatsu, Yuya Kodama, Takaaki Hiranaka, Keisuke Kintaka, Yusuke Kamatsuki, Toshifumi Ozaki

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie   2022年5月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Medial meniscus (MM) posterior root tears (PRTs) lead to abnormal kinematic changes in the knee and may induce pathological external rotation of the tibia during knee flexion. This study aimed to investigate changes in the length and inclination of the anterior cruciate ligament (ACL) after MM posterior root repair using magnetic resonance imaging (MRI). METHODS: This retrospective study included 44 patients who underwent MM posterior root repair between 2016 and 2019. Clinical outcomes were evaluated before and after surgery. MRI examinations were performed at 10°/90° of knee flexion preoperatively and 3 months postoperatively. The ACL length, proximal angle, and distal angle were determined using the sagittal view. MM extrusion and ACL inclination angle were determined using the coronal view. RESULTS: Clinical outcomes significantly improved 1 year after surgery. The postoperative ACL length (29.7 ± 2.4 mm) and proximal angle (47.0 ± 7.4°) at 90° of knee flexion decreased relative to the preoperative values (31.5 ± 2.3 mm and 51.8 ± 8.7°, P < 0.01). The postoperative ACL inclination (64.9 ± 5.6°) at 10° of knee flexion decreased relative to the preoperative value (69.7 ± 5.6°, P < 0.01). CONCLUSION: Pathologically-stretched linear ACL at 90° of knee flexion and a steep ACL inclination at 10° of knee flexion could be reduced after MM posterior root repair. This suggests that pullout repair could restore MM function as a secondary stabilizer, thereby preventing meniscal and cartilage degeneration.

    DOI: 10.1007/s00590-022-03285-0

    PubMed

    researchmap

  • Current management of giant-cell tumor of bone in the denosumab era 国際誌

    Akihito Nagano, Hiroshi Urakawa, Kazuhiro Tanaka, Toshifumi Ozaki

    Japanese Journal of Clinical Oncology   52 ( 5 )   411 - 416   2022年5月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    Giant-cell tumor of bone is a rare, locally aggressive and rarely metastasizing primary bone tumor. The mainstay of treatment remains controversial and is decided by the balance between adequate surgical margin and sufficient adjacent joint function. Although curettage with a high-speed burr and local adjuvants can maintain normal joint function, many reports have revealed a high local recurrence rate. Conversely, en bloc resection and reconstruction with prostheses for highly aggressive lesions have reportedly lower local recurrence rates and poorer functional outcomes. Denosumab—a full human monoclonal antibody that inhibits receptor activator of nuclear factor-kappa β ligand—was approved by the Food and Drug Authority in 2013 for use in surgically unresectable or when resection is likely to result in severe morbidity for skeletally mature adolescents and adults with giant-cell tumor of bone. However, subsequent studies have suggested that the local recurrence rate would be increased by preoperative use of denosumab. In systematic reviews of the local recurrence rate after preoperative use of denosumab, conclusions vary due to the small sample sizes of the studies reviewed. Therefore, controversy regarding the treatment of giant-cell tumor of bone is ongoing. Here, this review elucidates the management of giant-cell tumor of bone, especially with the local adjuvant and neoadjuvant use of denosumab, and presents the current, evidence-based treatment for giant-cell tumor of bone.

    DOI: 10.1093/jjco/hyac018

    PubMed

    researchmap

  • Increased cleft width during knee flexion is useful for the diagnosis of medial meniscus posterior root tears. 国際誌

    Takaaki Hiranaka, Takayuki Furumatsu, Shinichi Miyazawa, Keisuke Kintaka, Naohiro Higashihara, Masanori Tamura, Ximing Zhang, Haowei Xue, Toshifumi Ozaki

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA   2022年5月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: This study aimed to evaluate changes in the cleft width, defined as the distance between the lateral edge of the medial tibial plateau and that of the medial meniscus (MM) posterior root, using open magnetic resonance imaging (MRI) in patients with MM posterior root tear (MMPRT). METHODS: This study included 25 patients (20 women and 5 men; mean age: 65.2 years) who were diagnosed with MMPRT and underwent pullout repair. Upon coronal imaging, the cleft width was evaluated at the 10° and 90° flexed knee positions. The difference in the cleft width (defined as the cleft width at 90° minus the cleft width at 10°) was also calculated. Upon sagittal imaging, the MM posterior extrusion (MMPE) at 90° was also evaluated. Separate univariate linear regression models were used to determine the association between the time from injury to MRI and radiographic measurements. RESULTS: The mean cleft width at 10° and 90° was 4.9 ± 2.6 mm and 7.4 ± 3.7 mm, respectively; the mean difference in cleft width was 2.5 ± 1.5 mm, and the mean MMPE at 90° was 3.7 ± 1.3 mm. There was a significant difference in cleft width at 10° and 90° (p < 0.001). The time from injury to MRI was significantly associated with the cleft width at 10° (R = 0.42; p = 0.023), cleft width at 90° (R = 0.59; p = 0.002), the difference in the cleft width (R = 0.62; p = 0.008), and MMPE at 90° (R = 0.53; p = 0.008). CONCLUSION: This study demonstrates that the cleft width is significantly larger during knee flexion than during knee extension. Increased cleft width during knee flexion ("graben" sign) may help diagnose MMPRT, especially in cases where the cleft sign is unclear during knee extension. LEVEL OF EVIDENCE: III.

    DOI: 10.1007/s00167-022-06983-8

    PubMed

    researchmap

  • Application of mesh plate for the treatment of an osteochondral fracture of the medial femoral condyle with medial wall fracture: A case report. 国際誌

    Yusuke Mochizuki, Norio Yamamoto, Tomoyuki Noda, Toshifumi Ozaki

    Acta orthopaedica et traumatologica turcica   56 ( 3 )   228 - 231   2022年5月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Osteochondral fractures of the medial femoral condyle accompanied by medial wall fracture are rare. Surgeons often have difficulty in selecting the most appropriate treatment, especially the plating technique for internal fixation since the available femoral locking plates are made to fit the femoral lateral condyle and there is no anatomical plate for the medial condyle. We, herein, report a case of a 44-year- old female patient who suffered from an osteochondral fracture of the medial femoral condyle accompanied by medial wall fracture treated by a low-profile mesh plate contoured to fit around the fracture site. Bone union was achieved at postoperative week 12 and the patient was able to return to her normal activities. At the 16-month follow-up exam, the patient's functional and clinical outcomes were satisfactory. Her Oxford knee score was 47 points, and the Western Ontario and McMaster Universities Arthritis Index scores were 2 points for pain and 5 points for physical function. We believe that the mesh plate has several advantages. This is the first report of using a mesh plate for the femur, and we were able to achieve good results. We conclude that treatment with a mesh plate can be applied in well- selected patients with medial femoral condyle osteochondral fracture and has the potential to be applied to the treatment of fractures in various regions in the future.

    DOI: 10.5152/j.aott.2022.21325

    PubMed

    researchmap

  • 術前肺がん患者のサルコペニア・がんロコモと術後合併症の関連性

    堅山 佳美, 千田 益生, 中田 英二, 濱田 全紀, 国定 俊之, 藤原 智洋, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S35 - S35   2022年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • リハビリテーション専門病院での両下肢切断者の治療結果

    濱田 全紀, 堅山 佳美, 千田 益生, 茂山 幸雄, 坂本 吉宏, 徳弘 昭博, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S255 - S255   2022年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 臓器移植とリハビリテーション医療

    千田 益生, 濱田 全紀, 堅山 佳美, 濱崎 比果瑠, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S277 - S277   2022年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 臓器移植とリハビリテーション医療

    千田 益生, 濱田 全紀, 堅山 佳美, 濱崎 比果瑠, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S277 - S277   2022年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • リハビリテーション専門病院での両下肢切断者の治療結果

    濱田 全紀, 堅山 佳美, 千田 益生, 茂山 幸雄, 坂本 吉宏, 徳弘 昭博, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S255 - S255   2022年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 術前肺がん患者のサルコペニア・がんロコモと術後合併症の関連性

    堅山 佳美, 千田 益生, 中田 英二, 濱田 全紀, 国定 俊之, 藤原 智洋, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S35 - S35   2022年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 骨軟部腫瘍患者の術前ストレススクリーニング

    伊勢 真人, 藤原 智洋, 堅山 佳美, 中田 英二, 濱田 全紀, 國定 俊之, 千田 益生, 尾崎 敏文, 田島 文博

    The Japanese Journal of Rehabilitation Medicine   ( 特別号 )   S629 - S629   2022年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • Mechanical Study of Various Pedicle Screw Systems including Percutaneous Pedicle Screw in Trauma Treatment. 国際誌

    Yoshiaki Oda, Tomoyuki Takigawa, Yasuo Ito, Haruo Misawa, Tomoko Tetsunaga, Koji Uotani, Toshifumi Ozaki

    Medicina (Kaunas, Lithuania)   58 ( 5 )   2022年4月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and Objectives: Spine surgery using a percutaneous pedicle screw placement (PPSP) is widely implemented for spinal trauma. However, percutaneous systems have been reported to have weak screw-rod connections. In this study, conventional open and percutaneous systems were biomechanically evaluated and compared. Material and Methods: The experiments were performed in two stages: the first stage was a break test, whereas the second stage was a fatigue test. Four systems were used for the experiments. System 1 was intended for conventional open surgery (titanium rod with a 6.0 mm diameter, using a clamp connecting mechanism). System 2 was a percutaneous pedicle screw (PPS) system for trauma (titanium alloy rod with a 6.0 mm diameter, using ball ring connections). System 3 was a PPS system for trauma (cobalt-chromium alloy rod with a 6.0 mm diameter, using sagittal adjusting screw connections). System 4 was a general-purpose PPS system (titanium alloy rod with a 5.5 mm diameter, using a mechanism where the adapter in the head holds down the screw). Results: Stiffness values of 54.8 N/mm, 43.1 N/mm, 90.9 N/mm, and 39.3 N/mm were reported for systems 1, 2, 3, and 4, respectively. The average number of load cycles in the fatigue test was 134,393, 40,980, 1,550,389, and 147,724 for systems 1 to 4, respectively. At the end of the test, the displacements were 0.2 mm, 16.9 mm, 1.2 mm, and 8.6 mm, respectively. System 1, with a locking mechanism, showed the least displacement at the end of the test. Conclusion: A few PPS systems showed better results in terms on stiffness and life than the open system. The experiments showed that mechanical strength varies depending on the spinal implant. The experiments conducted are essential and significant to provide the mechanical strength required for surgical reconstruction.

    DOI: 10.3390/medicina58050565

    PubMed

    researchmap

  • A randomized phase III trial of denosumab before curettage for giant cell tumor of bone. JCOG1610

    Hiroshi Urakawa, Akihito Nagano, Ryunosuke Machida, Kazuhiro Tanaka, Tomoko Kataoka, Yuta Sekino, Yoshihiro Nishida, Mitsuru Takahashi, Toshiyuki Kunisada, Masanori Kawano, Yukihiro Yoshida, Tatsuya Takagi, Kenji Sato, Toru Hiruma, Hiroshi Hatano, Satoshi Tsukushi, Akio Sakamoto, Toshihiro Akisue, Koji Hiraoka, Toshifumi Ozaki

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   2022年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    Though JCOG1610 gave only descriptive results, the superiority of preoperative denosumab was not observed in patients with giant cell tumor of bone without possible post-operative large bone defect in terms of relapse-free survival.Objectives The aim of JCOG1610 (randomized controlled phase III trial) was to confirm the superiority of preoperative denosumab to curettage with adjuvant local therapy for patients with giant cell tumor of bone without possible post-operative large bone defect. Methods The primary endpoint was relapse-free survival and the total sample size was set at 106 patients. Patient accrual began in October 2017. However, the accrual was terminated in December 2020 due to a recommendation from the Data and Safety Monitoring Committee because of poor patient accrual. Now, we report the descriptive results obtained in this study. Results A total of 18 patients had been registered from 13 Japanese institutions at the time of termination on December 2020. Eleven patients were assigned to Arm A (curettage and adjuvant local therapy) and 7 to Arm B (preoperative denosumab, curettage and adjuvant local therapy). Median follow-up period was 1.6 (range: 0.5-2.8) years. Protocol treatment was completed in all but one patient in Arm A who had a pathological fracture before surgery. All patients in Arm B were treated with five courses of preoperative denosumab. Relapse-free survival proportions in Arm A and B were 90.0% (95% confidence interval: 47.3-98.5) and 100% (100-100) at 1 year, and 60.0% (19.0-85.5) and 62.5% (14.2-89.3) at 2 years, respectively [hazard ratio (95% confidence interval): 1.51 (0.24-9.41)]. Conclusion In terms of relapse-free survival, the superiority of preoperative denosumab was not observed in patients with giant cell tumor of bone without possible post-operative large bone defect.

    DOI: 10.1093/jjco/hyac071

    Web of Science

    researchmap

  • Grade of Subchondral Insufficiency Fracture of the Knee and the Presence of a Posterior Shiny-Corner Lesion are Correlated with Duration of Medial Meniscus Posterior Root Tear in Women.

    Yuki Okazaki, Takayuki Furumatsu, Takaaki Hiranaka, Yusuke Kamatsuki, Eiji Nakata, Tomonori Tetsunaga, Kentaro Yamane, Toshifumi Ozaki

    Acta medica Okayama   76 ( 2 )   121 - 127   2022年4月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Bone marrow edema (BME) after meniscus injury and risk factors for subchondral insufficiency fracture of the knee (SIFK) have been reported. However, their association with medial meniscus posterior root tear (MMPRT) remains unknown. We investigated the association of BME volume (BME-V), posterior shinycorner lesion (PSCL), and SIFK with MMPRT to examine the correlations between BME-V and medial meniscus extrusion (MME), PSCL and duration from injury to the time of magnetic resonance imaging (duration), and SIFK and duration. Twenty-nine patients who underwent surgery for MMPRT were included (mean age, 59.2; range, 39-84). The presence of PSCL, femoral BME-V (cm3), and SIFK grade (1-4) were evaluated. Preoperative factors, such as MME (mm) and duration (weeks), were investigated using multivariate linear/ logistic regression analyses. Multivariate linear regression analysis revealed duration as a significant factor for high-grade SIFK (p<0.01). Multivariate logistic regression analysis revealed duration as a significant factor for the presence of PSCL (odds ratio=0.94, p<0.05). A long duration of MMPRT leads to severe MME and highgrade SIFK (3 and 4), often resulting in knee arthroplasty. Early diagnosis of MMPRT and pullout repair can prevent severe MME and high-grade SIFK.

    DOI: 10.18926/AMO/63405

    PubMed

    researchmap

  • The role of perioperative chemotherapy in primary high-grade extremity soft tissue sarcoma: a risk-stratified analysis using PERSARC

    Ibtissam Acem, Winan J. van Houdt, Dirk J. Grünhagen, Winette T.A. van der Graaf, Anja J. Rueten-Budde, Hans Gelderblom, Cornelis Verhoef, Michiel A.J. van de Sande, Will Aston, Han Bonenkamp, Ingrid M.E. Desar, Peter C. Ferguson, Marta Fiocco, Robert J. van Ginkel, Anthony M. Griffin, Rick L. Haas, Jos A. van der Hage, Andrew J. Hayes, Lee M. Jeys, Akira Kawai, Johnny Keller, Minna K. Laitinen, Katja Maretty-Kongstad, Koichi Ogura, Toshifumi Ozaki, Rob Pollock, Veroniek M. van Praag, Stefan Sleijfer, Myles J. Smith, Maria A. Smolle, Emelie Styring, Joanna Szkandera, Kazuhiro Tanaka, Per-Ulf Tunn, Madeleine Willegger, Reinard Windhager, Jay S. Wunder, Olga Zaikova

    European Journal of Cancer   165   71 - 80   2022年4月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.ejca.2022.01.013

    researchmap

  • 骨軟部腫瘍患者におけるがん遺伝子パネル検査によるgermline findingの同定

    中田 英二, 藤原 智洋, 国定 俊之, 二川 摩周, 平沢 晃, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   65 ( 春季学会 )   125 - 125   2022年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • 術前術後CTと術中に計測した骨盤傾斜の角度の差についての比較検討

    小浦 卓, 鉄永 智紀, 佐藤 嘉洋, 廣瀬 一樹, 尾崎 敏文, 山田 和希

    中国・四国整形外科学会雑誌   34 ( 1 )   1 - 5   2022年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    Zimmer Biomet社Augmented Reality Hip Navigation System(AR Hip Navi)を用いてTHAを施行した11例11股を対象に検討した。骨盤傾斜角の計測方法は、術前・術後はCTデータをもとに三次元術前計画ソフトZedHipを用いて計測し、術中はAR Hip Naviを用いて計測した。結果、術前CTでの計測値は平均3.8度、術中AR Hip Naviでの計測値は平均-2.6度、術後CTでの計測値は平均4.1度であった。術前計測値と術中計測値との差の絶対値(術前-術中)は10.1度、術中計測値と術後計測値との差の絶対値(術中-術後)は9.9度、術前計測値と術後計測値との差の絶対値(術前-術後)は2.3度であり、術前-術後の計測値差に比べて術前-術中の計測値差と術中-術後の計測値差は有意に大きかった。

    researchmap

    その他リンク: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J02438&link_issn=&doc_id=20220608080001&doc_link_id=%2Fcm4ortho%2F2022%2F003401%2F001%2F0001-0005%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcm4ortho%2F2022%2F003401%2F001%2F0001-0005%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 内側楔状骨背側脱臼骨折の1例

    福岡 史朗, 依光 正則, 畑 利彰, 佐藤 浩平, 上原 健敬, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   65 ( 春季学会 )   199 - 199   2022年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • 脊椎手術を受ける患者から骨粗鬆症治療が必要な患者を見つけ出す

    高尾 真一郎, 三澤 治夫, 鉄永 倫子, 魚谷 弘二, 小田 孔明, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   65 ( 春季学会 )   111 - 111   2022年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • Management of elderly patients with bone and soft tissue sarcomas: JCOG Bone and Soft Tissue Tumor Study Group 国際誌

    Kazuhiro Tanaka, Toshifumi Ozaki

    Japanese Journal of Clinical Oncology   52 ( 6 )   526 - 530   2022年3月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    Approximately, 40% of bone sarcomas and 60% of soft tissue sarcoma arise in patients aged ≥65 years. However, because sarcoma is very rare, there is little evidence regarding the management of elderly patients with sarcoma. Age has been reported as a prognostic factor in patients with sarcomas. The standard therapy for all localized bone and soft tissue sarcomas is surgical resection, even in elderly patients. Radiation or ion-beam therapy can be considered for unresectable sarcomas. Although adjuvant chemotherapy is standard for osteosarcoma, the usefulness of adjuvant chemotherapy for elderly patients has not been verified; therefore, it may not be recommended for elderly patients with osteosarcoma. For elderly patients with advanced osteosarcoma, if general conditions permit, doxorubicin- and/or ifosfamide-based regimens as well as molecular-targeted therapies, including sorafenib, regorafenib and everolimus, may be considered, although these drugs have not been approved for sarcoma in Japan. Adjuvant chemotherapy with doxorubicin plus ifosfamide is recommended for patients with high-risk localized soft tissue sarcoma if they are aged ≤70 years. For first-line treatment of advanced soft tissue sarcoma in elderly patients, doxorubicin monotherapy is considered to be the standard regimen, and pazopanib can be an alternative. For second-line treatment, gemcitabine-based regimens, pazopanib, trabectedin and eribulin may be options for elderly patients with advanced soft tissue sarcoma.

    DOI: 10.1093/jjco/hyac027

    PubMed

    researchmap

  • Cumulated ambulation score as predictor of postoperative mobility in patients with proximal femur fractures

    Norio Yamamoto, Yosuke Tomita, Arisa Ichinose, Shintaro Sukegawa, Shigeki Yokoyama, Tomoyuki Noda, Keisuke Kawasaki, Toshifumi Ozaki

    Archives of Orthopaedic and Trauma Surgery   2022年3月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s00402-022-04401-9

    researchmap

    その他リンク: https://link.springer.com/article/10.1007/s00402-022-04401-9/fulltext.html

  • Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of soft tissue tumors 2020 - Secondary publication

    Akira Kawai, Nobuhito Araki, Keisuke Ae, Toru Akiyama, Toshifumi Ozaki, Hirotaka Kawano, Toshiyuki Kunisada, Minako Sumi, Shunji Takahashi, Kazuhiro Tanaka, Satoshi Tsukushi, Norifumi Naka, Yoshihiro Nishida, Mitsuru Miyachi, Norio Yamamoto, Akihiko Yoshida, Tsukasa Yonemoto, Masahiro Yoshida, Shintaro Iwata

    Journal of Orthopaedic Science   27 ( 3 )   533 - 550   2022年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    BACKGROUND: These clinical practice guidelines are intended to provide recommendations based on the best evidence obtained to date on key issues in clinical practice to improve the prognosis, diagnostic and therapeutic processes for patients with soft tissue tumors. METHODS: The Guidelines Development Committee and Systematic Review Committee were composed of a multidisciplinary team of specialists who play an important role in soft tissue tumor care. Clinical questions (CQs) were determined by choosing key decision-making points based on Algorithms for the diagnosis and treatment of soft tissue tumors. The guidelines were developed according to the "Medical Information Network Distribution Service (Minds) Handbook for Clinical Practice Guideline Development 2014" and "Minds Manual for Clinical Practice Guideline Development 2017." Recommendation strength was rated on two levels and the strength of evidence was rated on four levels. The recommendations were decided based on agreement by 70% or more voters. RESULTS: Twenty-two CQs were chosen by the Guidelines Development Committee. The Systematic Review Committee reviewed the evidence concerning each CQ, a clinical value judgment was added by experts, and the text of each recommendation was determined. CONCLUSION: We established 22 CQs and recommendations for key decision-making points in the diagnosis and treatment of soft tissue tumors according to the Minds Clinical Practice Guideline development methods. We hope that these guidelines will assist the decision-making of all medical staff engaged in the treatment and diagnosis of soft tissue tumors, and eventually lead to improved soft tissue tumor care in the country.

    DOI: 10.1016/j.jos.2021.11.023

    PubMed

    researchmap

  • Pre-and postoperative factors associated with functional outcomes in patients with posterior malleolar fractures

    Norio Yamamoto, Kohei Iwamoto, Yosuke Tomita, Yuki Iwamoto, Masahiro Kiyono, Masahide Yoshimura, Tomoyuki Noda, Keisuke Kawasaki, Toshifumi Ozaki

    Injury   2022年3月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.injury.2022.02.046

    researchmap

  • 慢性疼痛はコロナ禍における身体機能低下に与える影響は少ない

    鉄永 智紀, 鉄永 倫子, 三澤 治夫, 魚谷 弘二, 小田 孔明, 高尾 真一郎, 梶木 裕矢, 井上 忠俊, 尾崎 敏文, 田淵 貴大

    日本整形外科学会雑誌   96 ( 3 )   S781 - S781   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • がんゲノム中核拠点病院における、がん遺伝子パネルで同定されたGermline Findingsに対する診療システムの構築

    中田 英二, 二川 摩周, 国定 俊之, 藤原 智洋, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S439 - S439   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 人工肘関節全置換術を施行した関節リウマチ患者の上肢機能に影響を与える因子の検討

    松山 宜之, 那須 義久, 原田 遼三, 中原 龍一, 西田 圭一郎, 尾崎 敏文, 千田 益生

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   636 - 636   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 関節リウマチ患者に対する連結型人工肘関節全置換術(PROSNAP)の臨床成績の検討

    堀田 佳史, 西田 圭一郎, 浪花 崇一, 原田 遼三, 中原 龍一, 那須 義久, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   618 - 618   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 人工手関節置換術後のゆるみに対して他家骨移植を併用した全人工手関節固定術を施行した1例

    那須 義久, 西田 圭一郎, 中原 龍一, 浪花 崇一, 堀田 佳史, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   616 - 616   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 骨・軟部腫瘍診療の未来 骨・軟部腫瘍診療におけるAI診断の現状と未来

    長谷井 嬢, 中原 龍一, 国定 俊之, 中澤 慎二, 韓 昌煕, 藏品 豊, 木浪 陽, 藤原 一夫, 臼井 正明, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S479 - S479   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • AIを用いた骨端線の年齢変化の学習と単純X線画像自動生成

    中原 龍一, 西田 圭一郎, 長谷井 嬢, 中澤 慎二, 韓 昌煕, 藏品 豊, 那須 義久, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S427 - S427   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • リウマチ性疾患の上肢手術 関節リウマチに対するAVANTAとINTEGRAを用いたMCP人工指関節置換術の術後可動域の比較

    浪花 崇一, 堀田 佳史, 中原 龍一, 那須 義久, 西田 圭一郎, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   353 - 353   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 関節リウマチにおける外科的治療の意義-機能障害の回復を目指して- RA患者に対する人工肘関節全置換術による機能回復

    西田 圭一郎, 松山 宜之, 原田 遼三, 那須 義久, 中原 龍一, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   251 - 251   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 関節リウマチ治療のパラダイムシフトに伴う上肢手術とリハビリテーション-変遷と展望- 人工肘関節全置換術後のリハビリテーションの変遷と展望

    西田 圭一郎, 松山 宜之, 那須 義久, 原田 遼三, 中原 龍一, 千田 益生, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S413 - S413   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • リウマチ肘に対するPROSNAP人工肘関節置換術の短期成績

    堀田 佳史, 西田 圭一郎, 浪花 崇一, 中原 龍一, 那須 義久, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S247 - S247   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • その他の(多彩な)膠原病 機械学習を用いたサマリー自動可視化システムによるサマリー記載の標準化

    中原 龍一, 西田 圭一郎, 高橋 康, 浪花 崇一, 堀田 佳史, 那須 義久, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   477 - 477   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 肉腫におけるがん遺伝子パネルの有用性

    中田 英二, 国定 俊之, 藤原 智洋, 二川 摩周, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 3 )   S626 - S626   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Hip fractures following intramedullary nailing fixation for femoral fractures

    Norio Yamamoto, Yasuaki Yamakawa, Takashi Inokuchi, Yuki Iwamoto, Tomoo Inoue, Tomoyuki Noda, Keisuke Kawasaki, Toshifumi Ozaki

    Injury   53 ( 3 )   1190 - 1195   2022年3月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.injury.2021.10.024

    researchmap

  • A posterior anchoring method decreases pullout suture translation of the medial meniscus posterior root repair during knee flexion

    Yuki Okazaki, Takayuki Furumatsu, Takaaki Hiranaka, Keisuke Kintaka, Naohiro Higashihara, Masanori Tamura, Toshifumi Ozaki

    The Knee   35   71 - 80   2022年3月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.knee.2022.02.004

    researchmap

  • 脛骨髄内釘治療における術中X線透視を用いた近位回旋変形評価指標は何が適切か

    畑 利彰, 野田 知之, 上原 健敬, 依光 正則, 齋藤 太一, 島村 安則, 福岡 史朗, 佐藤 浩平, 近藤 宏也, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 3 )   S1029 - S1029   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 腱骨接合部の恒常性におけるメカニカルストレスの影響

    齋藤 太一, 根津 智史, 吉田 晶, 島村 安則, 西田 圭一郎, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S315 - S315   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 大腿骨転子部骨折患者における術前栄養状態、骨格筋量と術後歩行能力との関連性の検討

    佐藤 浩平, 依光 正則, 福岡 史朗, 近藤 宏也, 畑 利彰, 上原 健敬, 齋藤 太一, 島村 安則, 野田 知之, 東原 信七郎, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 3 )   S693 - S693   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 寛骨臼骨折における術後臨床成績評価方法の比較 Matta scoreとJHEQの比較検討

    近藤 宏也, 上原 健敬, 福岡 史朗, 佐藤 浩平, 畑 利彰, 齋藤 太一, 雑賀 建多, 島村 安則, 依光 正則, 野田 知之, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 3 )   S874 - S874   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 寛骨臼骨折前方アプローチ術後の腹部ヘルニア発生例の検討

    畑 利彰, 野田 知之, 上原 健敬, 依光 正則, 齋藤 太一, 島村 安則, 福岡 史朗, 佐藤 浩平, 近藤 宏也, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 3 )   S875 - S875   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨・軟部腫瘍診療の未来 骨・軟部腫瘍診療におけるAI診断の現状と未来

    長谷井 嬢, 中原 龍一, 国定 俊之, 中澤 慎二, 韓 昌煕, 藏品 豊, 木浪 陽, 藤原 一夫, 臼井 正明, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S479 - S479   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 60歳以上の術前がん患者のがんロコモとサルコペニアの有病率

    堅山 佳美, 中田 英二, 藤原 智洋, 国定 俊之, 濱田 全紀, 千田 益生, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S120 - S120   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • AIを用いた骨端線の年齢変化の学習と単純X線画像自動生成

    中原 龍一, 西田 圭一郎, 長谷井 嬢, 中澤 慎二, 韓 昌煕, 藏品 豊, 那須 義久, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S427 - S427   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • リウマチ性疾患の上肢手術 関節リウマチに対するAVANTAとINTEGRAを用いたMCP人工指関節置換術の術後可動域の比較

    浪花 崇一, 堀田 佳史, 中原 龍一, 那須 義久, 西田 圭一郎, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   353 - 353   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 診療ガイドラインに基づく治療は生存予後に寄与するか 軟部肉腫に対する補助化学療法の観点から米国における治療実態を検証する

    藤原 智洋, 小倉 浩一, Alaqeel Motaz, 尾崎 敏文, Healey John H.

    日本整形外科学会雑誌   96 ( 3 )   S601 - S601   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫におけるがん遺伝子パネルの有用性

    中田 英二, 国定 俊之, 藤原 智洋, 二川 摩周, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 3 )   S626 - S626   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 関節リウマチ患者に対する連結型人工肘関節全置換術(PROSNAP)の臨床成績の検討

    堀田 佳史, 西田 圭一郎, 浪花 崇一, 原田 遼三, 中原 龍一, 那須 義久, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   618 - 618   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 人工手関節置換術後のゆるみに対して他家骨移植を併用した全人工手関節固定術を施行した1例

    那須 義久, 西田 圭一郎, 中原 龍一, 浪花 崇一, 堀田 佳史, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   616 - 616   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • がんゲノム中核拠点病院における、がん遺伝子パネルで同定されたGermline Findingsに対する診療システムの構築

    中田 英二, 二川 摩周, 国定 俊之, 藤原 智洋, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S439 - S439   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 人工肘関節全置換術を施行した関節リウマチ患者の上肢機能に影響を与える因子の検討

    松山 宜之, 那須 義久, 原田 遼三, 中原 龍一, 西田 圭一郎, 尾崎 敏文, 千田 益生

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   636 - 636   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • リウマチ肘に対するPROSNAP人工肘関節置換術の短期成績

    堀田 佳史, 西田 圭一郎, 浪花 崇一, 中原 龍一, 那須 義久, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S247 - S247   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 本邦の胞巣状軟部肉腫に対する治療実態とその成績 全国骨・軟部腫瘍登録を用いた研究

    藤原 智洋, 中田 英二, 国定 俊之, 尾崎 敏文, 川井 章

    日本整形外科学会雑誌   96 ( 3 )   S1156 - S1156   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 関節リウマチにおける外科的治療の意義-機能障害の回復を目指して- RA患者に対する人工肘関節全置換術による機能回復

    西田 圭一郎, 松山 宜之, 原田 遼三, 那須 義久, 中原 龍一, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   251 - 251   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • 関節リウマチ治療のパラダイムシフトに伴う上肢手術とリハビリテーション-変遷と展望- 人工肘関節全置換術後のリハビリテーションの変遷と展望

    西田 圭一郎, 松山 宜之, 那須 義久, 原田 遼三, 中原 龍一, 千田 益生, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S413 - S413   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • その他の(多彩な)膠原病 機械学習を用いたサマリー自動可視化システムによるサマリー記載の標準化

    中原 龍一, 西田 圭一郎, 高橋 康, 浪花 崇一, 堀田 佳史, 那須 義久, 尾崎 敏文

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   477 - 477   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

    researchmap

  • DDH加療後のColonna手術後症例と保存的cast加療後の症例に対するTHAの手術成績比較 半世紀の経過観察

    遠藤 裕介, 山田 和希, 鉄永 智紀, 難波 良文, 三谷 茂, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 3 )   S788 - S788   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 発育性股関節形成不全に対する広範囲展開法術後の三次元動態解析

    山田 和希, 鉄永 智紀, 佐藤 嘉洋, 廣瀬 一樹, 小浦 卓, 遠藤 裕介, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S312 - S312   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 慢性疼痛はコロナ禍における身体機能低下に与える影響は少ない

    鉄永 智紀, 鉄永 倫子, 三澤 治夫, 魚谷 弘二, 小田 孔明, 高尾 真一郎, 梶木 裕矢, 井上 忠俊, 尾崎 敏文, 田淵 貴大

    日本整形外科学会雑誌   96 ( 3 )   S781 - S781   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • みんなで行う骨転移診療-診療均てん化を目指した整形外科キャリアステージ別スキルの再確認- 骨転移診療のスキル 外傷整形外科医編

    野田 知之, 阿部 信寛, 尾崎 敏文, 中田 英二, 依光 正則, 上原 健敬

    日本整形外科学会雑誌   96 ( 2 )   S477 - S477   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 集学的アプローチを用いた小児外傷患者に対する保護活動の実際

    上原 健敬, 依光 正則, 福岡 史朗, 佐藤 浩平, 畑 利彰, 島村 安則, 塚原 紘平, 中尾 篤典, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 2 )   S311 - S311   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • SER Stage IV Equivalent足関節外果骨折における三角靱帯深層線維損傷の有無の評価

    依光 正則, 上原 健敬, 福岡 史朗, 近藤 宏也, 畑 利彰, 佐藤 浩平, 尾崎 敏文, 野田 知之

    日本整形外科学会雑誌   96 ( 3 )   S1030 - S1030   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 大腿骨骨幹部骨折における骨癒合期間に影響する因子の検討

    福岡 史朗, 依光 正則, 佐藤 浩平, 近藤 宏也, 畑 利彰, 上原 健敬, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 3 )   S883 - S883   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • CT画像における腸腰筋評価と最大握力 DXAによる骨密度、骨折リスクとの関連

    梶木 裕矢, 三澤 治夫, 鉄永 倫子, 魚谷 弘二, 小田 孔明, 高尾 真一郎, 尾崎 敏文

    Journal of Spine Research   13 ( 3 )   568 - 568   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

    researchmap

  • 関節リウマチ患者における胸腰椎手術後の術後合併症および再手術の検討

    三澤 治夫, 小田 孔明, 魚谷 弘二, 鉄永 倫子, 高尾 真一郎, 梶木 裕矢, 尾崎 敏文

    Journal of Spine Research   13 ( 3 )   672 - 672   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

    researchmap

  • 骨密度と腸腰筋の各パラメーターとの関連 CT画像データを用いた検討

    高尾 真一郎, 三澤 治夫, 鉄永 倫子, 魚谷 弘二, 小田 孔明, 尾崎 敏文, 梶木 裕矢

    日本整形外科学会雑誌   96 ( 3 )   S919 - S919   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 単純CTによる脊椎転移脊柱管内進展の早期発見の可能性について

    魚谷 弘二, 三澤 治夫, 梶木 裕矢, 高尾 真一郎, 小田 孔明, 鉄永 倫子, 尾崎 敏文

    Journal of Spine Research   13 ( 3 )   299 - 299   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

    researchmap

  • 2ステップテストにおける体幹と下肢の三次元動作解析

    小田 孔明, 三澤 治夫, 鉄永 倫子, 魚谷 弘二, 高尾 真一郎, 梶木 裕矢, 尾崎 敏文

    Journal of Spine Research   13 ( 3 )   318 - 318   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

    researchmap

  • 転移性脊椎腫瘍脊柱管内進展の単純CTによる早期発見の可能性について

    魚谷 弘二, 小田 孔明, 三澤 治夫, 尾崎 敏文

    日本整形外科学会雑誌   96 ( 3 )   S761 - S761   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Three-Dimensional Analysis of the Ideal Entry Point for Sacral Alar Iliac Screws. 国際誌

    Noriyuki Watanabe, Tomoyuki Takigawa, Koji Uotani, Yoshiaki Oda, Haruo Misawa, Masato Tanaka, Toshifumi Ozaki

    Asian spine journal   16 ( 6 )   874 - 881   2022年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    STUDY DESIGN: This is a virtual three-dimensional (3D) imaging study examining computed tomography (CT) data to investigate instrumentation placement. PURPOSE: In this study, we aim to clarify the ideal entry point and trajectory of the sacral alar iliac (SAI) screw in relationship to the dorsal foramen at S1 and the respective nerve root. OVERVIEW OF LITERATURE: To the best of our knowledge, there is yet no detailed 3D imaging study on the ideal entry point of the SAI screw. Despite the evidence suggesting that the dorsal foramen at S1 is a landmark on the sacrum, the S1 nerve root disruption is a general concern during the insertion of SAI screws. No other study has been published examining the nerve root location at the S1and SAI screw insertions. METHODS: Preoperative CT data from 26 patients pertaining to adult spinal deformities were investigated in this study. We applied a 3D image processing method for a detailed investigation. Virtual cylinders were used to mimic SAI screws. These were placed to penetrate the sacral iliac joint without violating the other cortex. We then assessed the trajectory of the longest SAI screw and the ideal entry point of SAI using a color mapping method on the surface of the sacrum. We measured the location of the nerve root at S1 in relation to the foramen at S1 and the sacral surface. RESULTS: As per the results of our color mapping, it was determined that areas that received high scores are located medially and caudally to the dorsal foramen of S1. The mean angle between a horizontal line and a line connecting the medial edge of the foramen and nerve root at S1 was 93.5°. The mean distances from the dorsal medial edge of the foramen and sacral surface to S1 nerve root were 21.8 mm and 13.9 mm, respectively. CONCLUSIONS: The ideal entry point of the SAI screw is located medially and caudally to the S1 dorsal foramen based on 3D digital mapping. It is also shown that this entry point spares the S1 nerve root from possible iatrogenic injuries.

    DOI: 10.31616/asj.2021.0268

    PubMed

    researchmap

  • Preoperative and perioperative factors are related to the early postoperative Barthel Index score in patients with trochanteric fracture

    Yosuke Tomita, Norio Yamamoto, Tomoo Inoue, Arisa Ichinose, Tomoyuki Noda, Keisuke Kawasaki, Toshifumi Ozaki

    International Journal of Rehabilitation Research   Publish Ahead of Print   2022年2月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1097/mrr.0000000000000522

    researchmap

  • Association between Overall Survival and Activities of Daily Living in Patients with Spinal Bone Metastases 国際誌

    Yoshiteru Akezaki, Eiji Nakata, Masato Kikuuchi, Shinsuke Sugihara, Yoshimi Katayama, Haruyoshi Katayama, Masanori Hamada, Toshifumi Ozaki

    Healthcare   10 ( 2 )   350 - 350   2022年2月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Objective: This study aimed to investigate the association between overall survival (OS) and activities of daily living (ADL) in patients with skeletal-related events. In this study, 265 patients whose clinical parameters were available before radiotherapy were investigated. Methods: Age, sex, ADL, pain, the primary site, spinal level of bone metastases, spinal instability, treatment strategy, including chemotherapy or palliative treatment, and OS were investigated. ADL patients with a Barthel index of ≥90 were classified as the high ADL group, while those with a score &lt; 90 were classified as the low ADL group. For OS, patients surviving ≥160 days were classified as the non-poor prognosis group, and those who survived &lt;160 days were classified as the poor prognosis group. Results: Age, sex, ADL, pain, the primary site, and treatment strategy for OS were different between the two groups (p &lt; 0.1). Logistic regression analysis revealed that ADL, the primary site, and treatment strategy were significant predictors of OS (p &lt; 0.05). High ADL, breast cancer, and chemotherapy had a positive effect on OS. Conclusions: It is suggested that improvements may be obtained by performing rehabilitation interventions to maintain and improve ADL, by constructing a system for monitoring spinal bone metastases with images before ADL decreases, and by performing interventions such as changes in treatment methods such as RT or surgery at appropriate times.

    DOI: 10.3390/healthcare10020350

    PubMed

    researchmap

  • Intraoperative fractures in cephalomedullary nailing for trochanteric fractures

    Norio Yamamoto, Yasuaki Yamakawa, Yosuke Tomita, Tomoyuki Noda, Tomoo Inoue, Toshiyuki Matsumoto, Keisuke Kawasaki, Toshifumi Ozaki

    Injury   53 ( 2 )   561 - 568   2022年2月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.injury.2021.10.017

    researchmap

  • CD30-targeted therapy induces apoptosis of inflammatory cytokine-stimulated synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice. 国際誌

    Minami Matsuhashi, Keiichiro Nishida, Misa Sakamoto, Yuka Gion, Aki Yoshida, Takayuki Katsuyama, Ryuichi Nakahara, Yoshihisa Nasu, Yoshinori Matsumoto, Yasuharu Sato, Toshifumi Ozaki

    Inflammation research : official journal of the European Histamine Research Society ... [et al.]   71 ( 2 )   215 - 226   2022年2月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: It has been reported that levels of soluble CD30 in serum and joint fluid are significantly elevated in patients with rheumatoid arthritis (RA). This study aimed to investigate whether CD30 could be a therapeutic target for RA. METHODS: The expression and localization of CD30 were examined by immunohistochemical and double immunofluorescence staining on synovial tissue samples obtained from patients with RA or osteoarthritis (OA) during surgery. Changes in CD30 expression of fibroblast-like synoviocytes (FLS) from RA patients with or without TNFα and IL-1β stimulation were examined by the polymerase chain reaction (PCR) and flow cytometry. Collagen antibody-induced arthritis (CAIA) was created in DBA/1 mice, and the therapeutic effect of brentuximab vedotin (BV) was examined by clinical score, histological findings and measurement of serum levels of SAA, IL-6, and TNFα. RESULTS: CD30 expression was significantly higher in samples from patients with RA than from those with OA. Double immunofluorescence showed a low rate of co-localization of CD30 with CD20 or CD90, but a high rate of co-localization of CD30 and CD138. CD30 mRNA expression was upregulated 11.7-fold in FLS following stimulation by inflammatory cytokines. The clinical scores of CAIA mice were significantly lower following both BV treatments, however, the histological scores of CAIA mice were significantly lower only following treatment with high dose BV (70 mg/kg). CONCLUSIONS: CD30 was expressed on immunocompetent cells in synovial tissue from RA patients and in cytokine-stimulated FLS in vitro. High dose BV (70 mg/kg) showed significant therapeutic effects in ameliorating inflammation and joint destruction in CAIA mice, but low dose BV (30 mg/kg) was insufficient.

    DOI: 10.1007/s00011-021-01537-z

    PubMed

    researchmap

  • Corrigendum to ‘Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients’ [Eur J Cancer 141 (2020) 128-136]

    Ibtissam Acem, Cornelis Verhoef, Anja J. Rueten-Budde, Dirk J. Grünhagen, Winan J. van Houdt, Michiel A.J. van de Sande, Will Aston, Han Bonenkamp, Ingrid M.E. Desar, Peter C. Ferguson, Marta Fiocco, Hans Gelderblom, Robert J. van Ginkel, Winette van der Graaf, Anthony M. Griffin, Rick L. Haas, Jos A. van der Hage, Andrew J. Hayes, Lee M. Jeys, Johnny Keller, Minna K. Laitinen, Andreas Leithner, Katja Maretty-Kongstad, Toshifumi Ozaki, Rob Pollock, Veroniek M. van Praag, Myles J. Smith, Maria A. Smolle, Emelie Styring, Joanna Szkandera, Kazuhiro Tanaka, Per-Ulf Tunn, Madeleine Willegger, Reinard Windhager, Jay S. Wunder, Olga Zaikova

    European Journal of Cancer   162   247 - 249   2022年2月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.ejca.2021.12.002

    researchmap

  • 骨腫瘍切除後の配向連通孔構造を持つβ-TCPによる再建

    近藤 彩奈, 中田 英二, 国定 俊之, 藤原 智洋, たき平 将太, 近藤 宏也, 佐藤 浩平, 畑 利彰, 片山 晴喜, 尾崎 敏文

    移植   56 ( 4 )   456 - 456   2022年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

    researchmap

  • 変形性肩関節症とCCN3発現上昇との相関について

    廣瀬 一樹, 中田 英二, 服部 高子, 鉄永 智紀, 山田 和希, 佐藤 嘉洋, 桑原 実穂, 滝川 正春, 久保田 聡, 尾崎 敏文

    移植   56 ( 4 )   455 - 455   2022年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

    researchmap

  • Soft-tissue sarcoma in adolescents and young adults

    Toshiyuki Kunisada, Eiji Nakata, Tomohiro Fujiwara, Ako Hosono, Shota Takihira, Hiroya Kondo, Toshifumi Ozaki

    International Journal of Clinical Oncology   2022年1月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Soft-tissue sarcoma is a rare cancer that accounts for approximately 1% of all malignant tumors. Although they occur in various age groups, soft-tissue sarcomas account for 8% of all malignant tumors developing in adolescents and young adults, suggesting that they are not rare in this age group. This study aimed to evaluate the clinical and pathological characteristics of soft-tissue sarcoma in adolescents and young adults. According to the Bone and Soft-Tissue Tumor Registry in Japan, myxoid liposarcoma is the most common type of soft-tissue sarcoma found in adolescents and young adults; alveolar soft part sarcoma, extraskeletal Ewing sarcoma, epithelioid sarcoma, clear cell sarcoma and synovial sarcoma occur predominantly in this age group among soft-tissue sarcomas. The analysis based on this registry demonstrated that age was not a prognostic factor for poor survival of soft-tissue sarcoma, although the prognosis in adolescents and young adults was better than that in older patients in the US and Scandinavia. Adolescent and young adult patients with soft-tissue sarcoma have age-specific problems, and a multidisciplinary approach to physical, psychological, and social issues is necessary to improve the management of these young patients both during and after treatment.

    DOI: 10.1007/s10147-022-02119-7

    PubMed

    researchmap

    その他リンク: https://link.springer.com/article/10.1007/s10147-022-02119-7/fulltext.html

  • Outcome after resection arthroplasty or shortening oblique osteotomy of the lesser metatarsals combined with arthrodesis of the first metatarsophalangeal joint for severe rheumatoid forefoot deformities

    Masahiro Horita, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Kenta Saiga, Masanori Hamada, Toshifumi Ozaki

    Journal of Orthopaedic Surgery   30 ( 2 )   102255362211179 - 102255362211179   2022年1月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE Publications  

    Purpose

    We investigated objective and patient-reported outcomes after resection arthroplasty or shortening oblique osteotomy (SOO) of the lesser metatarsals combined with arthrodesis of the first metatarsophalangeal (MTP) joint for severe rheumatoid forefoot deformities.

    Methods

    17 feet from 14 women (mean age, 67.8 years) underwent resection arthroplasty of the lesser metatarsal heads (MTH resection group), while 13 feet from nine women and two men (mean age, 68.7 years) underwent SOO of the lesser metatarsals (MTH preservation group). Arthrodesis of the first MTP joint was performed in all cases. Mean follow-up in the MTH resection and preservation groups was 25.0 and 21.3 months, respectively. Preoperative and postoperative clinical evaluation included Japanese Society for Surgery of the Foot (JSSF) scale and self-administered foot evaluation questionnaire (SAFE-Q) scores.

    Results

    Mean total JSSF scale significantly improved from 53.4 to 76.4 in the MTH resection group ( p &lt; .001) and from 50.1 to 74.2 in the MTH preservation group ( p = .002). Pain and pain-related and shoe-related SAFE-Q subscale scores significantly improved after surgery in both groups. In the MTH resection group, recurrence of painful callosities and claw toe deformity was observed in four and three feet, respectively. In the MTH preservation group, one patient experienced recurrence of painful callosities and one underwent revision surgery for IP joint dislocation.

    Conclusion

    Resection arthroplasty or SOO of the lesser metatarsals combined with arthrodesis of the first MTP joint achieved significant improvement with respect to pain relief, deformity correction, and footwear comfort.

    DOI: 10.1177/10225536221117903

    researchmap

    その他リンク: http://journals.sagepub.com/doi/full-xml/10.1177/10225536221117903

  • Effect of difference in fixation methods of tendon graft and the microfracture procedure on tendon-bone junction healing

    Satoshi Nezu, Taichi Saito, Aki Yoshida, Shinji Narazaki, Yasunori Shimamura, Takayuki Furumatsu, Toshifumi Ozaki

    JSES International   6 ( 1 )   155 - 166   2022年1月

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

    Background: There are generally two methods of fixation for tendon grafts used in ligament reconstruction: bone tunnel fixation and anchor fixation. The microfracture (Mf) procedure is a technique to induce bleeding from the bone marrow, and the bleeding may contain cells with differentiation potential. However, few studies have compared the effects of the Mf procedure with those of the fixation methods. This study aimed to evaluate the effectiveness of the Mf procedure on two tendon graft fixation methods: histological, gene expression, tendon graft thickness, and mechanical. We especially focused our investigation on junction healing of tendon grafts and bone in the two fixation methods. Methods: We used 20 rabbits to evaluate tendon and bone healing in a peroneal tendon graft model. The rabbit models were divided into five groups according to the combination of peroneal tendon graft fixation method and Mf technique as follows: control group (C, n = 4), bone tunnel fixation without Mf procedure group (BT − Mf, n = 4), bone tunnel fixation with Mf procedure group (BT + Mf, n = 4), anchor fixation without Mf procedure group (A − Mf, n = 4), and anchor fixation with Mf procedure group (A + Mf, n = 4). All animals were sacrificed at 4 weeks postoperatively. The specimens underwent histological evaluation, mRNA analysis, tendon graft thickness at the tendon-bone junction, and biomechanical testing. Results: Histological evaluation of the BT + Mf and A + Mf groups showed healing with fibrocartilage formation at the tendon graft-bone junction. The mRNA expression showed significant increase in type 2 collagen, Scleraxis, and SRY-box9 in the BT + Mf and A + Mf groups. In biomechanical tests, the BT + Mf and A + Mf groups showed significantly increased tensile strength compared with the BT − Mf and A − Mf groups (BT + Mf group, 21.6 ± 1.7 N; A + Mf group, 22.5 ± 2.3 N vs. BT − Mf group, 12.3 ± 2.4 N; A − Mf group, 11 ± 2.3 N). Conclusion: The Mf procedure resulted in fibrocartilage formation at the tendon-bone junction in the BT and anchor fixation and improved the fixation strength at 4 weeks.

    DOI: 10.1016/j.jseint.2021.10.001

    Scopus

    researchmap

  • 生物学的製剤の使用は手術部位感染と創傷治癒遅延のリスク因子となるか

    木曽 洋平, 西田 圭一郎, 原田 遼三, 那須 義久, 中原 龍一, 堀田 佳史, 浪花 崇一, 尾崎 敏文

    関節の外科   49 ( 2 )   59 - 59   2022年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本リウマチの外科学会  

    researchmap

  • 上腕筋三頭筋温存アプローチ用いてPROSNAP人工肘関節置換術を施行した症例

    堀田 佳史, 西田 圭一郎, 志水 紀之, 中原 龍一, 那須 義久, 尾崎 敏文

    関節の外科   49 ( 2 )   106 - 106   2022年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本リウマチの外科学会  

    researchmap

  • The impact of system and diagnostic errors for medical litigation outcomes in orthopedic surgery.

    Norio Yamamoto, Takashi Watari, Ayako Shibata, Tomoyuki Noda, Toshifumi Ozaki

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   2021年12月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Medical litigation resulting from medical errors has a negative impact on health economics for both patients and medical practitioners. In medical litigation involving orthopedic surgeons, we aimed to identify factors contributing to plaintiff victory (orthopedic surgeon loss) through a comprehensive assessment. METHODS: This retrospective study included 166 litigation claims against orthopedic surgeons using a litigation database in Japan. We evaluated the sex and age of the patient (plaintiff), initial diagnosis, diagnostic error, system error, the time and place of each claim that led to malpractice litigation, the institution's size, and clinical outcomes. The main outcome was the litigation outcome (acceptance or rejection) in the final judgment. Acceptance meant that the orthopedic surgeon lost the malpractice lawsuit. We conducted multivariable logistic regression analyses to examine the association of factors with an accepted claim. RESULTS: The median age of the patients was 42 years, and 65.7% were male. The litigation outcome of 85 (51.2%) claims was acceptance. The adjusted median indemnity paid was $151,818. The multivariable analysis showed that diagnostic error, system error, sequelae, inadequate medical procedure, and follow-up observation were significantly associated with the orthopedic surgeon losing the lawsuit. In particular, claims involving diagnostic errors were more likely to be acceptance claims, in which the orthopedic surgeon lost (adjusted odds ratio 16.7, 95% confidence intervals: 4.7 to 58.0, p < 0.001). All of the claims in which the orthopedic surgeon lost were associated with a diagnostic or system error, with the most common one being system error. CONCLUSIONS: System errors and diagnostic errors were significantly associated with acceptance claims (orthopedic surgeon losses). Since these are modifiable factors, it is necessary to take measures not only for individual physicians but also for the overall medical management system to enhance patient safety and reduce the litigation risk of orthopedic surgeons.

    DOI: 10.1016/j.jos.2021.11.006

    PubMed

    researchmap

  • A characteristic MRI finding to diagnose a partial tear of the medial meniscus posterior root: an ocarina sign

    Takayuki Furumatsu, Takaaki Hiranaka, Keisuke Kintaka, Yuki Okazaki, Naohiro Higashihara, Masanori Tamura, Toshifumi Ozaki

    Knee Surgery & Related Research   33 ( 1 )   2021年12月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    <title>Abstract</title><sec>
    <title>Background</title>
    Diagnosing partial tears of the medial meniscus (MM) posterior root is difficult. The aim of this study was to evaluate diagnostic values involved in conventional magnetic resonance imaging (MRI) features of MM posterior root tears (MMPRTs) and find other MRI-based findings in patients with partial MMPRTs.


    </sec><sec>
    <title>Methods</title>
    Eighteen patients who had arthroscopically confirmed partial MMPRTs were included. As a control, 18 patients who underwent partial meniscectomy for other types of MM tears were evaluated. Isolated partial MMPRTs were classified into the following three types: type A, accurate partial stable tear (cleavage &lt; 1/2 of root width); type B, bridged unstable root tear (cleavage ≥ 1/2 of root width); type C, complex horn tear expanded to the root. Conventional MRI-based findings of MMPRTs were evaluated between two groups (<italic>n</italic> = 23). Posterior root irregularity, bone marrow spot, and ocarina-like appearance showing several condensed circles in triangular meniscal horn (ocarina sign) were also evaluated.


    </sec><sec>
    <title>Results</title>
    Posterior root irregularity and bone marrow spot were frequently observed in the partial MMPRTs (47.8%), compared with the other MM tears (<italic>P</italic> = 0.007 and 0.023, respectively). The ocarina sign was detected in 69.6% of patients with partial MMPRTs. A significant difference between two groups was observed in a positive ratio of ocarina sign (<italic>P</italic> &lt; 0.001). Types A, B, and C of the partial tear/damage were observed in three, eight, and seven patients, respectively. The ocarina sign was the most common MRI finding in each type of partial MMPRT.


    </sec><sec>
    <title>Conclusions</title>
    This study demonstrated that a characteristic MRI finding, “ocarina sign,” was frequently observed in patients with partial tear/damage of the MM posterior root. The ocarina sign was the most common MRI finding in several types of partial MMPRTs. Our results suggest that the ocarina sign may be useful to diagnose unnoticed partial MMPRTs.


    <italic>Level of evidence:</italic> IV, retrospective comparative study.


    </sec>

    DOI: 10.1186/s43019-021-00120-4

    researchmap

    その他リンク: https://link.springer.com/article/10.1186/s43019-021-00120-4/fulltext.html

  • Relationship between clinical outcomes and nerve conduction studies before and after surgery in patients with carpal tunnel syndrome 国際誌

    Masato Ise, Taichi Saito, Yoshimi Katayama, Ryuichi Nakahara, Yasunori Shimamura, Masanori Hamada, Masuo Senda, Toshifumi Ozaki

    BMC Musculoskeletal Disorders   22 ( 1 )   882 - 882   2021年12月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    <title>Abstract</title><sec>
    <title>Background</title>
    Nerve conduction study (NCS) is the only useful test for objective assessment of carpal tunnel syndrome (CTS). However, the relationship between pre- and postoperative NCS and clinical outcomes was unclear. This study aimed to determine whether pre- and postoperative (6 months) NCS could predict patient-oriented and motor outcomes (6 and 12 months postoperatively) in patients with CTS.


    </sec><sec>
    <title>Method</title>
    Of the 85 patients with CTS, 107 hands were analyzed from March 2011 to March 2020. All patients underwent open carpal tunnel release and were examined using the disabilities of the arm, shoulder and hand (DASH) questionnaire and grip strength (GS) preoperatively and 6 and 12 months postoperatively. Moreover, NCS was examined preoperatively and 6 months postoperatively. Distal motor latency (DML) and sensory conduction velocity (SCV) were the parameters used for NCS. The correlation coefficient between NCS and DASH or GS was calculated. A receiver operating characteristic curve was utilized to determine the NCS threshold value to predict DASH and GS improvement.


    </sec><sec>
    <title>Results</title>
    The average scores of GS preoperatively and 6 and 12 months postoperatively were 21.3, 22.3, and 22.8, respectively. On the other hand, the average scores of DASH preoperatively and 6 and 12 months postoperatively were 28.8, 18.3, and 12.2, respectively. The average NCS scores (DML and SCV) preoperatively/6 months postoperatively were 7.3/5.4 and 27.8/36.7, respectively. Preoperative NCS did not correlate with DASH and GS. Postoperative SCV correlated with the change in grip strength (6–12 months, <italic>r</italic> = 0.67; 0–12 months, <italic>r</italic> = 0.60) and DASH (0–12 months, <italic>r</italic> = 0.77). Moreover, postoperative DML correlated with the change in DASH (6–12 months, <italic>r</italic> = − 0.33; 0–12 months, <italic>r</italic> = − 0.59). The prediction for the improvement of GS/DASH achieved a sensitivity of 50.0%/66.7% and a specificity of 100%/100%, at an SCV cutoff score of 38.5/45.0 or above. The prediction for improvement of GS/DASH achieved a sensitivity of 83.3%/66.7% and a specificity of 100%/66.7% at a DML cutoff score of 4.4/4.4 or below.


    </sec><sec>
    <title>Conclusion</title>
    NCS at 6 months postoperatively can be used to predict the improvement of clinical outcome after 6 months postoperatively in patients with CTS.


    </sec>

    DOI: 10.1186/s12891-021-04771-y

    PubMed

    researchmap

    その他リンク: https://link.springer.com/article/10.1186/s12891-021-04771-y/fulltext.html

  • 股関節痛を契機に診断された強直性脊椎炎の1例

    山田 和希, 那須 義久, 鉄永 智紀, 佐藤 嘉洋, 廣瀬 一樹, 中原 龍一, 西田 圭一郎, 尾崎 敏文

    日本小児整形外科学会雑誌   30 ( 2 )   166 - 170   2021年12月

     詳細を見る

    担当区分:最終著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本小児整形外科学会  

    股関節痛を契機に診断に至った、強直性脊椎炎:ankylosing spondylitis(以下、AS)の1例を経験したので報告する。症例は16歳男子で、右股関節痛のため近医を受診した。大腿骨寛骨臼インピンジメントの診断で当科に紹介された。当科初診時、右股関節痛は安静時と夜間に強く、運動時には感じなかった。右股関節の可動域制限を認め疼痛誘発テストは陽性であった。詳細に問診したところ、過去に腰臀部痛と両股関節痛を繰り返していた。単純X線では左仙腸関節に硬化像を認め、MRIでは右股関節水腫と両仙腸関節周囲の骨髄浮腫像を認めた。血液検査では炎症反応が上昇し、HLA-B27は陽性であった。ASと診断し、疾患活動性が高かったため、Infliximabの適応とした。治療は奏効し、現在も継続している。詳細な病歴聴取により早期の診断と治療が行えたため、短期の成績ではあるが経過良好であった。(著者抄録)

    researchmap

  • 骨盤骨折に伴った腰仙骨神経叢損傷の1例

    伊勢 真人, 本郷 匡一, 堅山 佳美, 濱田 全紀, 千田 益生, 池田 吉宏, 茂山 幸雄, 徳弘 昭博, 尾崎 敏文

    末梢神経   32 ( 2 )   346 - 346   2021年12月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本末梢神経学会  

    researchmap

  • The Japanese Version of the Patient-Rated Elbow Evaluation is a Useful Outcome Measure that Potentially Reflects Hand Function in Patients with Rheumatoid Arthritis who Underwent Total Elbow Arthroplasty. 国際誌

    Ryozo Harada, Keiichiro Nishida, Yoshiyuki Matsuyama, Kenzo Hashizume, Takuro Wada, Yoshihisa Nasu, Ryuichi Nakahara, Masahiro Horita, Masuo Senda, Toshifumi Ozaki

    Modern rheumatology   32 ( 6 )   1041 - 1046   2021年11月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: We examined the relationship between The Japanese version of Patient-Related Elbow Evaluation (PREE-J) and other established subjective and objective outcome measures in Japanese patients with rheumatoid arthritis (RA) who underwent total elbow arthroplasty (TEA). PATIENTS AND METHODS: This study involved 46 elbows of 40 RA patients. We collected clinical data one year after surgery, including the PREE-J, the Mayo Elbow Performance Score (MEPS), Disability of the Arm, Shoulder, and Hand (DASH), and Hand20. The correlation and responsiveness to PREE-J were evaluated compared with other outcome measures pre-and postoperatively. RESULTS: Almost all outcome measures were improved significantly after surgery. Preoperative PREE-J was significantly correlated with preoperative DASH, Hand20, and MEPS. Interestingly, postoperative PREE-J did not correlate with postoperative MEPS. Multiple regression analyses revealed that preoperative grip strength (B = -0.09; 95% CI -0.17 to -0.01, p = 0.03) and preoperative Hand20 (B = 0.31, 95% CI 0.03 - 0.58, p = 0.03) were significant factors those might influenced the postoperative PREE-J. CONCLUSIONS: The PREE-J was shown to correlate well with other preoperative outcome measures among the RA patients included in the current study. The postoperative PREE-J after TEA was influenced by the preoperative grip strength and function of the hand.

    DOI: 10.1093/mr/roab100

    PubMed

    researchmap

  • The effect of mechanical stress on enthesis homeostasis in a rat Achilles enthesis organ culture model

    Taichi Saito, Ryo Nakamichi, Aki Yoshida, Takaaki Hiranaka, Yuki Okazaki, Satoshi Nezu, Minami Matsuhashi, Yasunori Shimamura, Takayuki Furumatsu, Keiichiro Nishida, Toshifumi Ozaki

    Journal of Orthopaedic Research   40 ( 8 )   1872 - 1882   2021年11月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/jor.25210

    researchmap

    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jor.25210

  • What are the Results of Resection of Forearm Soft Tissue Sarcoma?

    Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, Ryuichi Nakahara, Toshiyuki Watanabe, Toshifumi Ozaki

    2021年11月

     詳細を見る

    出版者・発行元:Research Square Platform LLC  

    Abstract

    Only few reports have assessed the characteristics and oncological and functional outcomes of forearm soft tissue sarcomas (STS). Then, we aimed to investigate the clinical features and survival-related factors for forearm STS who underwent surgical excision at our institution. There were 38 patients. Fourteen patients (41%) were referred to our institution after an unplanned excision and tumor size and grade were significantly associated with the receipt of it. The postoperative median Musculoskeletal Tumor Society rating scale (MSTS) score was 28. Bone resection or major nerve palsy was the only factor influencing the postoperative MSTS score (P &lt; 0.001). There was no significant difference in MSTS scores according to the reconstruction procedures (the use of flap or tendon reconstruction). The 5-year local recurrence-free survival (LRFS) rate was 86%. Univariate analysis revealed that the histological diagnosis of myxofibrosarcoma was the only factor that influenced LRFS (P = 0.047). The 5-year metastasis-free survival rate was 77%. The 5-year overall survival (OS) rate was 94%. Age was the only factor that influenced OS (P = 0.01). In conclusion, reconstruction of the skin and tendon can compensate for function. Careful follow-up is important, especially in patients with myxofibrosarcoma, due to its likelihood of local recurrence.

    DOI: 10.21203/rs.3.rs-1028963/v1

    researchmap

    その他リンク: https://www.researchsquare.com/article/rs-1028963/v1.html

  • Factors affecting the quality of life of patients with painful spinal bone metastases

    Yoshiteru Akezaki, Eiji Nakata, Masato Kikuuchi, Shinsuke Sugihara, Yoshimi Katayama, Haruki Katayama, Masanori Hamada, Toshifumi Ozaki

    Healthcare (Switzerland)   9 ( 11 )   2021年11月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)  

    This study examined changes in the quality of life (QOL), as well as the factors affecting QOL, among patients with painful spinal bone metastases without paralysis for 1 month after radiotherapy. Methods: This study included 79 participants (40 male and 39 female; median age, 65 (42–88) years) who had undergone radiotherapy for painful spinal bone metastases without paralysis. Patients’ age, sex, activities of daily living (Barthel index), pain, spinal instability (spinal instability neoplastic score [SINS]), and QOL (EORTC QLQ-C30) were investigated. Results: Having an unstable SINS score was a positive factor for global health status (p < 0.05). The improvement in activities of daily living and response to pain were positive factors for physical function (p < 0.05). A positive effect on emotional function was confirmed among female patients (p < 0.05). Conclusion: Engaging in rehabilitation along with radiotherapy leads to improvements in QOL for patients with spinal bone metastases.

    DOI: 10.3390/healthcare9111499

    Scopus

    researchmap

  • AIを用いた単純X線画像における骨端線変化の自動生成

    中原 龍一, 西田 圭一郎, 長谷井 嬢, 中澤 慎二, 韓 昌煕, 藏品 豊, 那須 義久, 尾崎 敏文

    日本関節病学会誌   40 ( 3 )   308 - 308   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本関節病学会  

    researchmap

  • 良性腫瘍に対する低侵襲治療 類骨骨種に対するRFA

    冨田 晃司, 馬越 紀行, 宇賀 麻由, 藤原 智洋, 松井 裕輔, 中田 英二, 生口 俊浩, 国定 俊之, 平木 隆夫, 尾崎 敏文

    日本小児整形外科学会雑誌   30 ( 3 )   S39 - S39   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本小児整形外科学会  

    researchmap

  • AIを用いた単純X線画像における骨端線変化の自動生成

    中原 龍一, 西田 圭一郎, 長谷井 嬢, 中澤 慎二, 韓 昌煕, 藏品 豊, 那須 義久, 尾崎 敏文

    日本関節病学会誌   40 ( 3 )   308 - 308   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本関節病学会  

    researchmap

  • 良性腫瘍に対する低侵襲治療 術中CTナビゲーションを用いた類骨骨腫に対する低侵襲手術

    藤原 智洋, 国定 俊之, 中田 英二, 尾崎 敏文

    日本小児整形外科学会雑誌   30 ( 3 )   S38 - S38   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本小児整形外科学会  

    researchmap

  • 腰仙椎の癒合がpincer lesionの原因と考えられた若年アスリートに発症した大腿骨寛骨臼インピンジメントの1例

    山田 和希, 鉄永 智紀, 佐藤 嘉洋, 廣瀬 一樹, 小浦 卓, 尾崎 敏文

    日本小児整形外科学会雑誌   30 ( 3 )   S131 - S131   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本小児整形外科学会  

    researchmap

  • 発育性股関節形成不全に対するSalter innominate osteotomyの短期成績

    廣瀬 一樹, 鉄永 智紀, 山田 和希, 佐藤 嘉洋, 小浦 卓, 尾崎 敏文

    日本小児整形外科学会雑誌   30 ( 3 )   S84 - S84   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本小児整形外科学会  

    researchmap

  • 麻痺性側彎 側彎症を伴う重症脳性麻痺児のQOL評価

    小田 孔明, 三澤 治夫, 鉄永 倫子, 魚谷 弘二, 赤澤 啓史, 青木 清, 尾崎 敏文

    日本小児整形外科学会雑誌   30 ( 3 )   S19 - S19   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本小児整形外科学会  

    researchmap

  • Postoperative clinical outcomes of unicompartmental knee arthroplasty in patients with isolated medial compartmental osteoarthritis following medial meniscus posterior root tear. 国際誌

    Takaaki Hiranaka, Takayuki Furumatsu, Yuki Okazaki, Takaaki Tanaka, Masatsugu Ozawa, Kenji Masuda, Noritaka Seno, Haowei Xue, Toshifumi Ozaki

    Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology   26   15 - 20   2021年10月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Cartilage degradation progresses rapidly following medial meniscus posterior root tear (MMPRT). Unicompartmental knee arthroplasty (UKA) has been performed for medial compartmental osteoarthritis following MMPRT. We evaluated the clinical and radiographic outcomes of UKA for medial compartmental osteoarthritis after an untreated MMPRT. Methods: Twenty-one patients who underwent UKA for isolated medial compartment osteoarthritis following MMPRT were retrospectively investigated. Clinical outcomes were assessed using the Knee Injury and Osteoarthritis Outcome Score and knee range of motion. The posterior tibial slope and tibial component inclination were evaluated using plain radiographs. Results: The mean follow-up periods were 25.5 ± 13.8 months. Clinical outcomes improved significantly postoperatively. The mean postoperative knee extension angle was -1.1° ± 2.1°, and the knee flexion angle was 134.3° ± 4.9°. The posterior tibial slope angle decreased from 9.0° ± 2.0° preoperatively to 5.4° ± 1.8° postoperatively, and postoperative tibial component inclination at the final follow-up was 2.9° ± 1.1° varus. No aseptic loosening or deep infections were observed. Conclusion: UKA significantly improved clinical outcomes and could be a viable surgical option for treating isolated medial compartmental osteoarthritis accompanied by untreated MMPRT.

    DOI: 10.1016/j.asmart.2021.07.005

    PubMed

    researchmap

  • 変形性肩関節症モデルとしてのCCN3過剰発現マウス

    廣瀬 一樹, 服部 高子, 中田 英二, 鉄永 智紀, 山田 和希, 佐藤 嘉洋, 桑原 実穂, 尾崎 敏文, 滝川 正春, 久保田 聡

    日本骨代謝学会学術集会プログラム抄録集   39回   151 - 151   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨代謝学会  

    researchmap

  • 脛骨プラトー・骨幹部合併骨折3例の治療経験

    福岡 史朗, 依光 正則, 近藤 宏也, 佐藤 浩平, 畑 利彰, 上原 健敬, 尾崎 敏文

    中国・四国整形外科学会雑誌   33 ( 3 )   330 - 330   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 術前がん患者におけるがんロコモ・サルコペニアの有病率

    堅山 佳美, 中田 英二, 濱田 全紀, 国定 俊之, 藤原 智洋, 千田 益生, 尾崎 敏文

    中国・四国整形外科学会雑誌   33 ( 3 )   324 - 324   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 内側半月板後根断裂患者における術前と術後1年の下肢機能の比較検討

    濱崎 比果瑠, 千田 益生, 濱田 全紀, 堅山 佳美, 宮澤 慎一, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   58 ( 秋季特別号 )   S372 - S372   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • リハビリテーション関連機器の現状と課題

    千田 益生, 濱田 全紀, 堅山 佳美, 伊勢 真人, 本郷 匡一, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   58 ( 秋季特別号 )   S185 - S185   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • 術前肺がん患者の筋肉量と術後合併症の関連性

    堅山 佳美, 千田 益生, 濱田 全紀, 濱崎 比果瑠, 尾崎 敏文

    The Japanese Journal of Rehabilitation Medicine   58 ( 秋季特別号 )   S374 - S374   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

    researchmap

  • Mechanical stretching induces calcification and cartilage matrix metabolism, causing degeneration of the acetabular labrum 国際誌

    Yoshi Kawamura, Tomonori Tetsunaga, Kazuki Yamada, Tomoaki Sanki, Yoshihiro Sato, Aki Yoshida, Takayuki Furumatsu, Toshifumi Ozaki

    HIP International   112070002110446 - 112070002110446   2021年9月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE Publications  

    <sec><title>Purpose:</title> The acetabular labrum plays an important role in joint lubrication, and damage to this structure leads to osteoarthritis. This study aimed to histologically classify the degree of degeneration of the acetabular labrum and to investigate the changes in gene expression induced by mechanical stretching.

    </sec><sec><title>Methods:</title> We obtained acetabular labrum cells from patients with hip osteoarthritis during total hip arthroplasty ( n = 25). The labrum was stained with safranin O, and images were histologically evaluated using a new parameter, the red/blue (R/B) value. The samples were divided into the degenerated group (D group: n = 18) and the healthy group (H group: n = 7) in accordance with the Kellgren-Lawrence (KL) grade. The cultured acetabular labral cells were subjected to loaded uniaxial cyclic tensile strain (CTS). After CTS, changes in gene expression were examined in both groups.

    </sec><sec><title>Results:</title> Spearman’s correlation analysis revealed that the R/B value was significantly correlated with the KL grade and the Krenn score. The expression levels of genes related to cartilage metabolism, osteogenesis and angiogenesis significantly increased after CTS in the H group, while gene expression in the D group showed weaker changes after CTS than that in the H group compared to the nonstretched control group.

    </sec><sec><title>Conclusions:</title> The degree of labral degeneration could be classified histologically using the R/B value and the KL grade. Mechanical stretching caused changes in gene expression that support the pathological features of labral degeneration.

    </sec>

    DOI: 10.1177/11207000211044675

    PubMed

    researchmap

    その他リンク: http://journals.sagepub.com/doi/full-xml/10.1177/11207000211044675

  • Adipose-Derived Extract Suppresses IL-1β-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats

    Hideki Ohashi, Keiichiro Nishida, Aki Yoshida, Yoshihisa Nasu, Ryuichi Nakahara, Yoshinori Matsumoto, Ayumu Takeshita, Daisuke Kaneda, Masanori Saeki, Toshifumi Ozaki

    International Journal of Molecular Sciences   22 ( 18 )   9781 - 9781   2021年9月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    We investigated the effects of adipose-derived extract (AE) on cultured chondrocytes and in vivo cartilage destruction. AE was prepared from human adipose tissues using a nonenzymatic approach. Cultured human chondrocytes were stimulated with interleukin-1 beta (IL-1β) with or without different concentrations of AE. The effects of co-treatment with AE on intracellular signaling pathways and their downstream gene and protein expressions were examined using real-time PCR, Western blotting, and immunofluorescence staining. Rat AE prepared from inguinal adipose tissues was intra-articularly delivered to the knee joints of rats with experimental osteoarthritis (OA), and the effect of AE on cartilage destruction was evaluated histologically. In vitro, co-treatment with IL-1β combined with AE reduced activation of the p38 and ERK mitogen-activated protein kinase (MAPK) pathway and nuclear translocation of the p65 subunit of nuclear factor-kappa B (NF-κB), and subsequently downregulated the expressions of matrix metalloproteinase (MMP)-1, MMP-3, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, IL-6, and IL-8, whereas it markedly upregulated the expression of IL-1 receptor type 2 (IL-1R2) in chondrocytes. Intra-articular injection of homologous AE significantly ameliorated cartilage destruction six weeks postoperatively in the rat OA model. These results suggested that AE may exert a chondroprotective effect, at least in part, through modulation of the IL-1β-induced inflammatory signaling pathway by upregulation of IL-1R2 expression.

    DOI: 10.3390/ijms22189781

    researchmap

  • Transtibial pullout repair of medial meniscus posterior root tears: effects on the meniscus healing score and ICRS grade among patients with mild osteoarthritis of the knee. 国際誌

    Yuya Kodama, Takayuki Furumatsu, Yuki Okazaki, Shota Takihira, Takaaki Hiranaka, Shinichi Miyazawa, Yusuke Kamatsuki, Toshifumi Ozaki

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA   29 ( 9 )   3001 - 3009   2021年9月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To assess the effects of transtibial pullout repair for medial meniscus posterior root tears (MMPRTs) among patients with early osteoarthritis of the knee as measured by the meniscus healing score and to determine whether the meniscus healing score correlates with the International Cartilage Repair Society (ICRS) grade progression. METHODS: Forty-seven patients with mild osteoarthritic knees (Kellgren-Lawrence grade ≤ 2 and varus alignment < 5°) who underwent transtibial pullout repair less than 3 months after MMPRT onset were assessed. The association between meniscus healing scores at 1 year postoperatively and cartilage damage of the medial compartment (medial femoral condyle [MFC] and medial tibial plateau [MTP]) were evaluated. The MFC was divided into six zones (A to F) and the MTP into two zones (G and H). The mean ICRS grade for each zone was compared between the primary surgery and second-look arthroscopy. The correlation between cartilage damage and meniscus healing status at the time of second-look arthroscopy in each zone was analysed. RESULTS: The mean time interval from injury to surgery was 63 days, and all clinical scores showed significant improvement. There were no significant differences in the extent of cartilage damage in areas B, C, E, or F (n.s.) for MFC or in areas G and H (n.s.) for MTP. The meniscus healing score and cartilage damage were correlated in the loading areas (B, C, E, and H; - 0.53, - 0.45, - 0.33, and - 0.38, respectively; p < 0.05). CONCLUSION: Transtibial pullout repair of MMPRTs among patients with mild osteoarthritic knees improved the clinical outcomes and showed a negative correlation between high meniscus healing scores and ICRS grades in the medial compartment loading area. This study suggests that early surgery should be undertaken for patients with mild osteoarthritic knee who develop MMPRTs. LEVEL OF EVIDENCE: Level IV.

    DOI: 10.1007/s00167-020-06332-7

    PubMed

    researchmap

  • Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression. 国際誌

    Kazuhisa Sugiu, Hiroshi Tazawa, Joe Hasei, Yasuaki Yamakawa, Toshinori Omori, Tadashi Komatsubara, Yusuke Mochizuki, Hiroya Kondo, Shuhei Osaki, Tomohiro Fujiwara, Aki Yoshida, Toshiyuki Kunisada, Koji Ueda, Yasuo Urata, Shunsuke Kagawa, Toshifumi Ozaki, Toshiyoshi Fujiwara

    Cancer chemotherapy and pharmacology   88 ( 3 )   513 - 524   2021年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Osteosarcoma (OS) is a malignant bone tumor primarily affecting children and adolescents. The prognosis of chemotherapy-refractory OS patients is poor. We developed a tumor suppressor p53-expressing oncolytic adenovirus (OBP-702) that exhibits antitumor effects against human OS cells. Here, we demonstrate the chemosensitizing effect of OBP-702 in human OS cells. MATERIALS AND METHODS: The in vitro and in vivo antitumor activities of doxorubicin (DOX) and OBP-702 were assessed using parental and DOX-resistant OS cells (U2OS, MNNG/HOS) and a DOX-resistant MNNG/HOS xenograft tumor model. RESULTS: DOX-resistant OS cells exhibited high multidrug resistant 1 (MDR1) expression, which was suppressed by OBP-702 or MDR1 siRNA, resulting in enhanced DOX-induced apoptosis. Compared to monotherapy, OBP-702 and DOX combination therapy significantly suppressed tumor growth in the DOX-resistant MNNG/HOS xenograft tumor model. CONCLUSION: Our results suggest that MDR1 is an attractive therapeutic target for chemoresistant OS. Tumor-specific virotherapy is thus a promising strategy for reversing chemoresistance in OS patients via suppression of MDR1 expression.

    DOI: 10.1007/s00280-021-04310-5

    PubMed

    researchmap

  • Semi-quantitative arthroscopic scoring system is related to clinical outcomes in patients after medial meniscus posterior root repair

    Ximing Zhang, Takayuki Furumatsu, Yuki Okazaki, Takaaki Hiranaka, Keisuke Kintaka, Haowei Xue, Shinichi Miyazawa, Toshifumi Ozaki

    Journal of Orthopaedic Science   2021年9月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.jos.2021.07.023

    researchmap

  • Comparison of two simple stitches and modified Mason-Allen suture for medial meniscus posterior root tear based on the progression of meniscal posterior extrusion: A retrospective cohort study

    Keisuke Kintaka, Takayuki Furumatsu, Yuki Okazaki, Shin Masuda, Takaaki Hiranaka, Yuya Kodama, Yusuke Kamatsuki, Toshifumi Ozaki

    Journal of Orthopaedic Surgery   29 ( 3 )   230949902110495 - 230949902110495   2021年9月

     詳細を見る

    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE Publications  

    Purpose: Medial meniscus (MM) posterior root (PR) tear leads to severe MM posterior extrusion (PE), resulting in rapid knee cartilage degeneration. MMPR repairs are recommended to reduce MMPE, especially during knee flexion. However, the difference in MMPE between different repair techniques remains unknown. This study aimed to investigate preoperative and postoperative MMPE following several pullout repair techniques. We hypothesized that a technique using two simple stitches (TSS) would be more useful than FasT-Fix-dependent modified Mason-Allen suture (F-MMA) to prevent the progression of MMPE in knee extension. Methods: This retrospective study included 35 patients who underwent MMPR repair. To compare MMPE, patients were divided into two groups according to the use of F-MMA while grasping the posterior capsule and TSS without grasping it. Open magnetic resonance imaging was performed at 10° and 90° knee flexion preoperatively, and at 3 and 12 months postoperatively, and the MMPE of both groups was evaluated. Results: A significant difference was observed between preoperative and 3-month postoperative MMPE at 90° knee flexion in both groups ( p &lt; .01). A significant difference was observed in 3- and 12-month postoperative MMPE at 10° knee flexion between both groups ( p = .04/.02), whereas no significant difference in the preoperative MMPE at 10° knee flexion was observed between them ( p = .45). Conclusions: Both repairs were found to be useful to reduce MMPE in knee flexion. Further, F-MMA repair increased MMPE in knee extension, unlike TSS repair. These findings suggest that TSS might have more advantages for load distribution when standing or walking.

    DOI: 10.1177/23094990211049569

    researchmap

    その他リンク: http://journals.sagepub.com/doi/full-xml/10.1177/23094990211049569

  • 肉腫におけるがん遺伝子パネルによる融合遺伝子の検出

    中田 英二, 国定 俊之, 藤原 智洋, 遠西 大輔, 冨田 秀太, 尾崎 敏文

    中部日本整形外科災害外科学会雑誌   64 ( 秋季学会 )   107 - 107   2021年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)中部日本整形外科災害外科学会  

    researchmap

  • 尺骨非定型骨折の2例

    望月 雄介, 齋藤 太一, 尾崎 敏文

    中国・四国整形外科学会雑誌   33 ( 2 )   216 - 216   2021年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:中国・四国整形外科学会  

    researchmap

  • 肺転移能を有する骨肉腫細胞はM2様マクロファージへの分化を強力に誘導する

    近藤 宏也, 田澤 大, 久禮 美穂, 藤原 智洋, 国定 俊之, 尾崎 敏文, 藤原 俊義

    日本癌学会総会記事   80回   [J14 - 4]   2021年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本癌学会  

    researchmap

  • Effect of Patient Clinical Variables in Osteoporosis Classification Using Hip X-rays in Deep Learning Analysis. 国際誌

    Norio Yamamoto, Shintaro Sukegawa, Kazutaka Yamashita, Masaki Manabe, Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Toshifumi Ozaki, Keisuke Kawasaki, Hitoshi Nagatsuka, Yoshihiko Furuki, Takashi Yorifuji

    Medicina (Kaunas, Lithuania)   57 ( 8 )   2021年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and Objectives: A few deep learning studies have reported that combining image features with patient variables enhanced identification accuracy compared with image-only models. However, previous studies have not statistically reported the additional effect of patient variables on the image-only models. This study aimed to statistically evaluate the osteoporosis identification ability of deep learning by combining hip radiographs with patient variables. Materials andMethods: We collected a dataset containing 1699 images from patients who underwent skeletal-bone-mineral density measurements and hip radiography at a general hospital from 2014 to 2021. Osteoporosis was assessed from hip radiographs using convolutional neural network (CNN) models (ResNet18, 34, 50, 101, and 152). We also investigated ensemble models with patient clinical variables added to each CNN. Accuracy, precision, recall, specificity, F1 score, and area under the curve (AUC) were calculated as performance metrics. Furthermore, we statistically compared the accuracy of the image-only model with that of an ensemble model that included images plus patient factors, including effect size for each performance metric. Results: All metrics were improved in the ResNet34 ensemble model compared with the image-only model. The AUC score in the ensemble model was significantly improved compared with the image-only model (difference 0.004; 95% CI 0.002-0.0007; p = 0.0004, effect size: 0.871). Conclusions: This study revealed the additional effect of patient variables in identification of osteoporosis using deep CNNs with hip radiographs. Our results provided evidence that the patient variables had additive synergistic effects on the image in osteoporosis identification.

    DOI: 10.3390/medicina57080846

    PubMed

    researchmap

  • CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment. 国際誌

    Tomohiro Fujiwara, Mohamed A Yakoub, Andrew Chandler, Alexander B Christ, Guangli Yang, Ouathek Ouerfelli, Vinagolu K Rajasekhar, Aki Yoshida, Hiroya Kondo, Toshiaki Hata, Hiroshi Tazawa, Yildirim Dogan, Malcolm A S Moore, Toshiyoshi Fujiwara, Toshifumi Ozaki, Ed Purdue, John H Healey

    Molecular cancer therapeutics   20 ( 8 )   1388 - 1399   2021年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Colony-stimulating factor 1 (CSF1) is a primary regulator of the survival, proliferation, and differentiation of monocyte/macrophage that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). Considering current advances in understanding the role of the inflammatory tumor microenvironment, targeting the components of the sarcoma microenvironment, such as TAMs, is a viable strategy. Here, we investigated the effect of PLX3397 (pexidartinib) as a potent inhibitor of the CSF1 receptor (CSF1R). PLX3397 was recently approved by the Food and Drug Administration (FDA) to treat tenosynovial giant cell tumor and reprogram TAMs whose infiltration correlates with unfavorable prognosis of sarcomas. First, we confirmed by cytokine arrays of tumor-conditioned media (TCM) that cytokines including CSF1 are secreted from LM8 osteosarcoma cells and NFSa fibrosarcoma cells. The TCM, like CSF1, stimulated ERK1/2 phosphorylation in bone marrow-derived macrophages (BMDMs), polarized BMDMs toward an M2 (TAM-like) phenotype, and strikingly promoted BMDM chemotaxis. In vitro administration of PLX3397 suppressed pERK1/2 stimulation by CSF1 or TCM, and reduced M2 polarization, survival, and chemotaxis in BMDMs. Systemic administration of PLX3397 to the osteosarcoma orthotopic xenograft model significantly suppressed the primary tumor growth and lung metastasis, and thus improved metastasis-free survival. PLX3397 treatment concurrently depleted TAMs and FOXP3+ regulatory T cells and, surprisingly, enhanced infiltration of CD8+ T cells into the microenvironments of both primary and metastatic osteosarcoma sites. Our preclinical results show that PLX3397 has strong macrophage- and T-cell-modulating effects that may translate into cancer immunotherapy for bone and soft-tissue sarcomas.

    DOI: 10.1158/1535-7163.MCT-20-0591

    PubMed

    researchmap

  • Induction and expansion of human PRRX1+ limb-bud-like mesenchymal cells from pluripotent stem cells. 国際誌

    Daisuke Yamada, Masahiro Nakamura, Tomoka Takao, Shota Takihira, Aki Yoshida, Shunsuke Kawai, Akihiro Miura, Lu Ming, Hiroyuki Yoshitomi, Mai Gozu, Kumi Okamoto, Hironori Hojo, Naoyuki Kusaka, Ryosuke Iwai, Eiji Nakata, Toshifumi Ozaki, Junya Toguchida, Takeshi Takarada

    Nature biomedical engineering   5 ( 8 )   926 - 940   2021年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Current protocols for the differentiation of human pluripotent stem cells (hPSCs) into chondrocytes do not allow for the expansion of intermediate progenitors so as to prospectively assess their chondrogenic potential. Here we report a protocol that leverages PRRX1-tdTomato reporter hPSCs for the selective induction of expandable and ontogenetically defined PRRX1+ limb-bud-like mesenchymal cells under defined xeno-free conditions, and the prospective assessment of the cells' chondrogenic potential via the cell-surface markers CD90, CD140B and CD82. The cells, which proliferated stably and exhibited the potential to undergo chondrogenic differentiation, formed hyaline cartilaginous-like tissue commensurate to their PRRX1-expression levels. Moreover, we show that limb-bud-like mesenchymal cells derived from patient-derived induced hPSCs can be used to identify therapeutic candidates for type II collagenopathy and we developed a method to generate uniformly sized hyaline cartilaginous-like particles by plating the cells on culture dishes coated with spots of a zwitterionic polymer. PRRX1+ limb-bud-like mesenchymal cells could facilitate the mass production of chondrocytes and cartilaginous tissues for applications in drug screening and tissue engineering.

    DOI: 10.1038/s41551-021-00778-x

    PubMed

    researchmap

  • Letter regarding "Clinical outcomes and trans-syndesmotic screw frequency after posterior malleolar fracture osteosynthesis". 国際誌

    Norio Yamamoto, Yosuke Tomita, Tomoyuki Noda, Kohei Iwamoto, Toshifumi Ozaki

    Injury   52 ( 8 )   2479 - 2480   2021年8月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.injury.2020.11.023

    PubMed

    researchmap

  • Two simple stitches for medial meniscus posterior root repair prevents the progression of meniscal extrusion and reduces intrameniscal signal intensity better than modified Mason-Allen sutures. 国際誌

    Yuki Okazaki, Takayuki Furumatsu, Takaaki Hiranaka, Yuya Kodama, Yusuke Kamatsuki, Keisuke Kintaka, Toshifumi Ozaki

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie   31 ( 6 )   1005 - 1013   2021年8月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Medial meniscus posterior root tears (MMPRTs) can cause severe medial extrusion of the medial meniscus (MMME) and the progression of knee degenerative changes, inducing a high signal intensity of the meniscus on magnetic resonance imaging (MRI). Although MMME and intrameniscal signal intensity (IMSI) reportedly decreased within 3 months after MMPRT repair, no previous studies have reported these changes after a 1-year follow-up. This study aimed to investigate the 1-year postoperative changes in MMME and IMSI on MRI after using different suture techniques. METHODS: Overall, 33 patients with MMPRT were evaluated, 22 underwent FasT-Fix-dependent modified Mason-Allen suture (F-MMA) repair, and 11 underwent two simple stitches (TSS) repair. MRI examinations were performed preoperatively and 1 year postoperatively. MMME and IMSI were determined using MRI. RESULTS: A significant decrease in postoperative MMME was observed in the TSS group (4.1 ± 1.0) relative to that in the F-MMA group (5.1 ± 1.4, P = 0.03). A significant decrease in postoperative IMSI (0.75 ± 0.14) was observed relative to preoperative IMSI in the TSS group (P < 0.01), whereas postoperative IMSI (0.94 ± 0.25) was similar to preoperative IMSI in the F-MMA group (P = 0.06). Furthermore, a significant decrease in postoperative IMSI was observed in the TSS group relative to that in the F-MMA group (P < 0.01). CONCLUSIONS: The most important finding of this study is that TSS repair yielded a greater decrease in MMME and IMSI than F-MMA repair in patients with MMPRT. These results suggest that TSS repair is more useful for restoring loading stress to the posterior horn of the medial meniscus.

    DOI: 10.1007/s00590-020-02830-z

    PubMed

    researchmap

  • Assessment of the concordance rate between intraoperative pathological diagnosis and the final pathological diagnosis of spinal cord tumors

    Muraoka S, Yamane K, Misawa H, Takigawa T, Tetsunaga T, Oda Y, Nakanishi K, Ozaki T, Tanaka T

    Acta Med Okayama   75 ( 4 )   455 - 460   2021年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The intraoperative pathological diagnosis (IPD) plays an important role in determining the optimal surgical treatment for spinal cord tumors. The final pathological diagnosis (FPD) is sometimes different from the IPD. Here, we sought to identify the accuracy of the IPD of spinal cord tumors compared to the FPD. We retrospec-tively analyzed the cases of 108 patients with spinal cord tumors treated surgically in our institute; the IPD, FPD, mismatched cases, and concordance rate between the IPD and FPD were investigated. Five cases involved a mismatch between the IPD and FPD. The overall concordance rate was 95.4%, with 90.9% for extra-dural lesions, 98.5% for intradural extramedullary lesions, 84.2% for intramedullary lesions, and 100% for dumbbell-type tumors. The concordance rate of intramedullary lesions tended to be lower than that of other lesions (p = 0.096). A lower concordance rate was revealed for intramedullary lesions compared to the other lesions. Despite the IPD clearly remaining a valuable tool during operative procedures, surgeons should recog-nize the limitations of IPDs and make comprehensive decisions about surgical treatments.

    DOI: 10.18926/AMO/62397

    PubMed

    researchmap

  • Medial meniscus posterior root repair using a modified Mason-Allen suture can prevent the progression of cartilage degeneration on the loading surface of the medial compartment: a second-look arthroscopic evaluation

    Takihira S, Furumatsu T, Okazaki Yuki, Hiranaka T, Kintaka K, Kodama Y, Kamatsuki Y, Miyazawa S, Ozaki T

    Acta Med Okayama   75 ( 4 )   423 - 430   2021年8月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/62380.

    researchmap

  • がん患者における周術期のがんロコモの発生率とそのリスクファクター

    堅山 佳美, 中田 英二, 明崎 禎輝, 千田 益生, 国定 俊之, 濱田 全紀, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1580 - S1580   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 変形性肩関節症とCCN3発現上昇との相関について

    廣瀬 一樹, 中田 英二, 服部 高子, 鉄永 智紀, 山田 和希, 佐藤 嘉洋, 桑原 実穂, 滝川 正春, 久保田 聡, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1506 - S1506   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • ISB座標系と後顆平面座標系を用いた3D-CT計測と従来法による大腿骨骨幹部骨折術後の回旋変形の比較

    佐藤 浩平, 上原 健敬, 福岡 史朗, 近藤 宏也, 畑 利彰, 齋藤 太一, 島村 安則, 野田 知之, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1688 - S1688   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 移植腱固定法の違いとmicrofracture手技が腱 骨接合部癒合に与える影響

    根津 智史, 齋藤 太一, 吉田 晶, 島村 安則, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1828 - S1828   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • ISB座標系と後顆平面座標系を用いた3D-CT計測と従来法による大腿骨骨幹部骨折術後の回旋変形の比較

    佐藤 浩平, 上原 健敬, 福岡 史朗, 近藤 宏也, 畑 利彰, 齋藤 太一, 島村 安則, 野田 知之, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1688 - S1688   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 教師なし学習を用いたAIによる超音波画像撮像部位自動検出

    中原 龍一, 高橋 康, 西田 圭一郎, 那須 義久, 渡辺 雅仁, 松橋 美波, 堀田 佳史, 品岡 玲, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1726 - S1726   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 人工知能を用いた骨肉腫X線像読影ツールの開発

    長谷井 嬢, 中原 龍一, 沖田 駿治, 三宅 孝昌, 木浪 陽, 藤原 一夫, 臼井 正明, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1475 - S1475   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 移植腱固定法の違いとmicrofracture手技が腱 骨接合部癒合に与える影響

    根津 智史, 齋藤 太一, 吉田 晶, 島村 安則, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1828 - S1828   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Pexidartinibの骨肉腫に対する前臨床的検討 CSF-1/CSF-1R阻害は肉腫微小環境の免疫細胞構成分画を変化させ抗腫瘍効果を発揮する

    藤原 智洋, Yakoub Mohamed, 吉田 晶, 近藤 宏也, 畑 利彰, 佐藤 浩平, たき平 将太, 中田 英二, 国定 俊之, 尾崎 敏文, Healey John

    日本整形外科学会雑誌   95 ( 8 )   S1557 - S1557   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 悪性末梢神経鞘腫瘍におけるPRRX1の悪性化因子としての役割

    たき平 将太, 山田 大祐, 高尾 知佳, 中田 英二, 近藤 宏也, 佐藤 浩平, 畑 利彰, 藤原 智洋, 国定 俊之, 尾崎 敏文, 宝田 剛志

    日本整形外科学会雑誌   95 ( 8 )   S1554 - S1554   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 腫瘍関連マクロファージを誘導するCSF-1の分泌と血中発現の解析 浸潤性軟部肉腫における検討

    畑 利彰, 藤原 智洋, 吉田 晶, 近藤 彩奈, 片山 晴喜, 佐藤 浩平, 近藤 宏也, たき平 将太, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1552 - S1552   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨肉腫における腫瘍関連マクロファージの役割とin vitro実験による検証

    近藤 宏也, 田澤 大, 久禮 美穂, 藤原 智洋, 佐藤 浩平, 畑 利彰, 中田 英二, 国定 俊之, 藤原 俊義, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1556 - S1556   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫におけるがんゲノム医療の意義

    中田 英二, 国定 俊之, 藤原 智洋, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1549 - S1549   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 変形性肩関節症とCCN3発現上昇との相関について

    廣瀬 一樹, 中田 英二, 服部 高子, 鉄永 智紀, 山田 和希, 佐藤 嘉洋, 桑原 実穂, 滝川 正春, 久保田 聡, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1506 - S1506   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • がん患者における周術期のがんロコモの発生率とそのリスクファクター

    堅山 佳美, 中田 英二, 明崎 禎輝, 千田 益生, 国定 俊之, 濱田 全紀, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 8 )   S1580 - S1580   2021年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Adjuvant and neoadjuvant chemotherapy for osteosarcoma: JCOG Bone and Soft Tissue Tumor Study Group. 国際誌

    Hiroaki Hiraga, Toshifumi Ozaki

    Japanese journal of clinical oncology   2021年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The usefulness of adjuvant chemotherapy for high-grade osteosarcoma was established by two randomized, controlled trials conducted in the 1980s, which used six drugs, doxorubicin, cisplatin, high-dose methotrexate, bleomycin, cyclophosphamide and actinomycin D. Since then, development has been promoted in the direction of introducing preoperative chemotherapy, changing post-operative adjuvant chemotherapy according to histological effects, adding ifosfamide as a key drug and strengthening adjuvant chemotherapy. No clinical trials, however, have shown the effectiveness of study treatment, and the improvement of treatment results during that time has been slight, although the JCOG0905 study is now going to verify the effectiveness of introducing ifosfamide for patients who experienced limited preoperative therapeutic effects. We are desperately looking for a breakthrough.

    DOI: 10.1093/jjco/hyab120

    PubMed

    researchmap

  • Psoas muscle index predicts osteoporosis and fracture risk in individuals with degenerative spinal disease. 国際誌

    Yuya Kajiki, Hironori Tsuji, Haruo Misawa, Ryuichi Nakahara, Tomoko Tetsunaga, Kentaro Yamane, Yoshiaki Oda, Shinichiro Takao, Toshifumi Ozaki

    Nutrition (Burbank, Los Angeles County, Calif.)   93   111428 - 111428   2021年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Skeletal muscle loss and osteoporosis are major medical and socioeconomic concerns as the global population ages. Studies have reported that skeletal muscle mass correlates to bone mineral density (BMD). The psoas muscle index (PMI), measured as the L3 cross-sectional areas of the right and left psoas divided by the square of height, has a positive correlation with the total volume of skeletal muscle in the body. This study aimed to evaluate relationships between PMI and BMD and fracture risk estimated by the Fracture Risk Assessment Tool (FRAX). METHODS: Preoperatively acquired, plain computed tomography images at the L3 level were used to measure PMI in 87 people with degenerative spinal diseases. We evaluated the correlation between PMI and BMD and fracture risk estimated by FRAX. RESULTS: PMI was significantly correlated with BMD in the entire lumbar spine and femoral neck (r = 0.413 and 0.525, both P < 0.001). People with osteoporosis showed significantly lower PMI than those without (P < 0.05). PMI was also significantly correlated with FRAX score (r = -0.545, P < 0.001). Furthermore, based on the recommendation of osteoporosis treatment, participants were divided into two groups: FRAX ≥15% (R group) and FRAX <15% (C group). The R group showed significantly lower PMI than the C group (P < 0.001). Receiver operating characteristic curve analysis revealed that PMI has moderate accuracy in diagnosing osteoporosis and FRAX ≥15%. CONCLUSIONS: PMI was significantly associated with BMD and fracture risk. PMI measurement is straightforward and may increase the diagnosis rate of osteoporosis and fracture risk.

    DOI: 10.1016/j.nut.2021.111428

    PubMed

    researchmap

  • A Novel Radiographic Measurement Method for the Evaluation of Metatarsophalangeal Joint Dislocation of the Lesser Toe in Patients with Rheumatoid Arthritis. 国際誌

    Hideki Ohashi, Keiichiro Nishida, Yoshihisa Nasu, Kenta Saiga, Ryuichi Nakahara, Masahiro Horita, Shunji Okita, Toshifumi Ozaki

    International journal of environmental research and public health   18 ( 14 )   2021年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Dorsal dislocation of metatarsophalangeal (MTP) joints of the lesser toe frequently occurs in patients with rheumatoid arthritis (RA), and may cause painful and uncomfortable plantar callosities and ulceration. The current study examined the reliability and clinical relevance of a novel radiographic parameter (the MTP overlap distance [MOD]) in evaluating the severity of MTP joint dislocation. The subjects of the current study were 147 RA patients (276 feet; 1104 toes). MOD, defined as the overlap distance of the metatarsal head and the proximal end of the phalanx, was measured on plain radiographs. The relationship between the MOD and clinical complaints (forefoot pain and/or callosity formation) was analyzed to create a severity grading system. As a result, toes with callosities had a significantly larger MOD. ROC analysis revealed that the MOD had a high AUC for predicting an asymptomatic foot (-0.70) and callosities (0.89). MOD grades were defined as follows: grade 1, 0 ≤ MOD < 5 mm; grade 2, 5 ≤ MOD < 10 mm; and grade 3, MOD ≥ 10 mm. The intra- and inter-observer reliability of the MOD grade had high reproducibility. Furthermore, the MOD and MOD grade improved significantly after joint-preserving surgeries for lesser toe deformities. Our results suggest that MOD and MOD grade might be useful tools for the evaluation of deformities of the lesser toe and the effect of surgical intervention for MTP joints in patients with RA.

    DOI: 10.3390/ijerph18147520

    PubMed

    researchmap

  • Cement augmentation of internal fixation for trochanteric fracture: a systematic review and meta-analysis. 国際誌

    Norio Yamamoto, Takahisa Ogawa, Masahiro Banno, Jun Watanabe, Tomoyuki Noda, Haggai Schermann, Toshifumi Ozaki

    European journal of trauma and emergency surgery : official publication of the European Trauma Society   48 ( 3 )   1699 - 1709   2021年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: This study aimed to determine the efficacy and safety of cement augmentation for internally fixed trochanteric fractures through a systematic review and meta-analysis of randomized controlled trials (RCTs). METHODS: We searched the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov databases to identify RCTs, published until July 2020 that examined the effects of cement augmentation of internal fixation of trochanteric fractures. The primary outcomes were reoperation and Parker Mobility Score, whereas the secondary outcomes were 1-year mortality rate, EuroQol 5 Dimension, fixation failures, and adverse events. We conducted meta-analyses of the outcome measures using the random-effects models. We evaluated the certainty of evidence based on the Cochrane risk-of-bias tool and the Grading of Recommendations, Assessment, Development, and Evaluation approach. RESULTS: We included three RCTs (326 participants). No significant effect was observed in favor of cement augmentation on all these outcomes. The certainty of evidence for fixation failures was very low and that for the other outcomes was low. The overall risk of bias for each outcome was high or of some concern in all included studies. CONCLUSIONS: The effect of cement augmentation of internal fixation of trochanteric fractures was uncertain for the clinical outcomes due to the low certainty of evidence. Further RCTs with a low risk of selection bias may present convincing conclusions on the efficacy and safety of cement augmentation. LEVEL OF EVIDENCE: Level 1.

    DOI: 10.1007/s00068-021-01746-5

    PubMed

    researchmap

  • Postoperative external tibial rotation is correlated with inferior meniscal healing following pullout repair of a medial meniscus posterior root tear. 国際誌

    Takaaki Hiranaka, Takayuki Furumatsu, Yuki Okazaki, Keisuke Kintaka, Yusuke Kamatsuki, Ximing Zhang, Haowei Xue, Toshifumi Ozaki

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA   2021年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The purpose of this study was to evaluate the influence of tibial rotation on the postoperative healing status of the medial meniscus (MM) following pullout repair of the MM posterior root tear (MMPRT). METHODS: Ninety-one patients (68 women and 23 men; mean age 63.3 ± 8.8 years) who had undergone transtibial pullout repair of MMPRT were enrolled in the study. The tibial external rotation angle (ERA) in each patient was measured postoperatively using computed tomography in the extended knee position. The meniscal healing status following transtibial pullout repair was assessed by second-look arthroscopy (mean postoperative period 12 months) using a previously published scoring system (range 0-10). The association between the ERA and the meniscal healing score was investigated using univariate linear regression models. The ERA cut-off for improved meniscal healing score (≥ 7) was determined using receiver-operating characteristic analysis. RESULTS: The ERA and the meniscal healing score were significantly associated, confirming that increased ERAs were correlated with worse meniscal healing status (R =  - 0.28; P < 0.001). The optimum ERA cut-off value was 0.5°, with a sensitivity of 68% and a specificity of 63%. The mean meniscal healing scores were 7.3 and 6.2 among patients with ERAs < 0.5° and those with ERAs ≥ 0.5°, respectively (P < 0.001). CONCLUSION: This study demonstrated that the ERA was significantly correlated with the postoperative meniscal healing status. Postoperative tibial rotation could be one of the factors affecting postoperative outcomes of pullout repair of MMPRT. Controlling the tibial rotation may possibly improve meniscal healing. LEVEL OF EVIDENCE: III.

    DOI: 10.1007/s00167-021-06656-y

    PubMed

    researchmap

  • Spinopelvic fixation with retention of external fixation in a lateral position for unstable pelvic fracture. 国際誌

    Norio Yamamoto, Hisanori Ikuma, Tomoyuki Noda, Tomoo Inoue, Keisuke Kawasaki, Toshifumi Ozaki

    Orthopaedics & traumatology, surgery & research : OTSR   103008 - 103008   2021年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Anterior external fixation (EF), as the primary treatment for unstable pelvic fractures, is performed with patients in the supine position. In most cases, however, definitive surgery for posterior fixation is performed first in the prone position without EF. We report the case of a patient with unilateral and vertically unstable pelvic fracture whom we had treated with minimally invasive spinopelvic fixation, with retention of the anterior EF in a lateral position. Reduction of the residual displacement was performed with percutaneous spinal instrumentation, and acceptable reduction was achieved. At the 13-month follow-up, the functional outcome, calculated using the Majeed Score, was 87 points. The plain radiograph showed good bone union, except for the right superior pubic ramus. The radiological outcome, measured using the Matta rating, was excellent. Thus, retaining the EF facilitates safe and accurate reduction without major surgical complications and may offer surgeons an additional management option for such fractures.

    DOI: 10.1016/j.otsr.2021.103008

    PubMed

    researchmap

  • Symptomatic Venous Thromboembolism in Patients with Malignant Bone and Soft Tissue Tumors: A Prospective Multicenter Cohort Study

    Shintaro Iwata, Akira Kawai, Takafumi Ueda, Takeshi Ishii, Tsukasa Yonemoto, Tsukasa Yonemoto, Hiroto Kamoda, Yoshihisa Suzuki, Kazutaka Kikuta, Jungo Imanishi, Taketo Okubo, Yasuo Yazawa, Tsukasa Sotobori, Hiroaki Murata, Toshifumi Ozaki, Toshiyuki Kunisada, Tomohiro Fujiwara, Shigeki Kakunaga, Koji Hiraoka, Tetsuya Hamada, Kotaro Matsuda, Takashi Yanagawa, Kenichi Saito, Hirofumi Namba, Motohiro Kawasaki, Shunji Nishimura, Kazuhiko Hashimoto, Takeshi Okamoto, Ukei Anazawa, Itsuo Watanabe, Michiyuki Hakozaki, Yoshinori Imura, Yoshinori Imura, Eisuke Kobayashi, Koichi Ogura, Taketoshi Yasuda, Kayo Suzuki, Toru Akiyama, Masami Hosaka, Munenori Watanuki, Kou Hayashi, Toshiharu Shirai, Ryu Terauchi, Hisaki Aiba, Hiroaki Kimura, Kunihiro Asanuma, Tomoki Nakamura, Tomohito Hagi, Satoshi Abe, Kenji Sato, Yukihiro Yoshida, Yoshiyuki Suehara, Keisuke Akaike, Hiroaki Hiraga, Tamotsu Soma, Hiroshi Kobayashi, Yusuke Shinoda, Ryoko Sawada

    ANNALS OF SURGICAL ONCOLOGY   28 ( 7 )   3919 - 3927   2021年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Background A prospective cohort study was conducted to determine the incidence and risk factors of symptomatic venous thromboembolism (sVTE) during the perioperative period in patients with malignant bone and soft tissue tumors. Methods Patients with newly diagnosed primary malignant bone and soft tissue tumors for whom definitive surgery was planned were consecutively registered among 27 tertiary hospitals specializing in musculoskeletal oncology. Clinicopathological information on each patient was collected prospectively, and careful follow-up was conducted for 6 months after surgery. The study endpoint was the occurrence of sVTE, including deep vein thrombosis (DVT) and pulmonary embolism (PE). Results Eleven of 929 patients developed sVTE, including 8 patients with DVT, 2 with PE, and 1 with both, making the incidence of sVTE 1.18%. The median time until the development of sVTE after tumor resection was 11 days, ranging from - 7 to 95 days. Multiple logistic regression analyses revealed that ischemic heart disease as a comorbidity, maximum tumor diameter exceeding 8 cm, and elevated preoperative platelet count were independent risk factors for sVTE. Conclusions The incidence of sVTE in this series of patients with bone and soft tissue sarcomas was 1.18%, which was relatively lower than in previous retrospective studies. We identified the risk factors for sVTE specific to patients with malignant bone and soft tissue tumors, and these included ischemic heart disease, tumor size, and elevation of the preoperative platelet count.

    DOI: 10.1245/s10434-020-09308-6

    Web of Science

    researchmap

  • Treatment for postoperative infection of pathological femoral fracture after radiotherapy: two case reports and review of the literature. 国際誌

    Minami Matsuhashi, Taichi Saito, Tomoyuki Noda, Takenori Uehara, Yasunori Shimamura, Toshifumi Ozaki

    Archives of orthopaedic and trauma surgery   141 ( 7 )   1139 - 1148   2021年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Radiation-induced pathological fractures show high nonunion and infection rates. Successful treatment of postoperative infections of these fractures without limb amputation is extremely rare. METHODS: We report two cases of postoperative infection of pathological femoral fracture after radiation therapy for soft tissue tumors. Considering the poor condition of the irradiated site, a two-staged operation was selected to create the optimal situation for bone union. The treatment involved the Masquelet technique, latissimus dorsi (LD) flap, and a free vascularized fibula graft (FVFG). In the first stage, we drastically resected the necrotic bone and the surrounding infected tissue and placed antibiotic polymethylmethacrylate space on the bone gap according to the Masquelet technique. Next, we used an Ilizarov external fixator as a temporizing stabilizer and performed the LD flap. Six weeks later, in the second stage, we changed the external fixation to plate fixation; packed the artificial bone (β-TCP) and autograft bone to the induced membrane; and performed FVFG on the other side of the plate. As postoperative therapy, toe touch was allowed immediately, and partial weight bearing was started 2 months after second surgery. RESULTS: Both patients achieved bone union and were able to walk without postoperative complications. At the 2-year follow-up, there was no recurrence of infection. CONCLUSION: Our treatment is effective for controlling postoperative infection of radiation-induced pathological fracture.

    DOI: 10.1007/s00402-020-03493-5

    PubMed

    researchmap

  • Clinical prediction model for postoperative ambulatory ability outcomes in patients with trochanteric fractures. 国際誌

    Yosuke Tomita, Norio Yamamoto, Tomoo Inoue, Tomoyuki Noda, Keisuke Kawasaki, Toshifumi Ozaki

    Injury   52 ( 7 )   1826 - 1832   2021年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Regaining independent ambulatory ability is one of the primary goals of treatment in patients with trochanteric fractures. This study aimed to develop and evaluate the discriminative accuracy of a clinical prediction model for ambulatory ability outcomes 3 months after surgery for trochanteric fractures. METHODS: This retrospective cohort study included 346 patients treated with intramedullary nailing for trochanteric fractures who had independent ambulatory ability before their injury. Multiple regression models with preoperative and postoperative factors were used to predict ambulatory ability outcomes at 3 months. A clinical prediction model (CPM) was created based on a decision tree developed using a chi-square automatic interaction detector technique. RESULTS: Three months after surgery, 263 (76.0%) and 83 (24.0%) patients regained and lost independent ambulatory ability, respectively. Univariate analysis showed that the Barthel index (BI) total score at 2 weeks predicted the ambulatory ability outcome at 3 months with good discriminative accuracy (area under the receiver operating characteristic curve [AUROC]: 0.819; 95% confidence interval [CI]: [0.769, 0.868], cut-off value: 22.5; sensitivity: 69.5%; specificity: 82.3%). Multiple logistic regression analysis showed that preoperative factors (residence before injury, diagnosis of dementia, and serum albumin at admission) and postoperative factors (BI total score at 2 weeks) predicted ambulatory ability outcomes at 3 months (AUROC: 0.710; 95%CI: [0.636, 0.783]; sensitivity: 91.3%; specificity: 41.8%). The CPM with the BI total score at 2 weeks (≤10; 10<, ≤50; >50 points) and dementia status (present; absent) had a moderate discriminative accuracy (AUROC: 0.676; 95%CI: [0.600, 0.752]; sensitivity: 94.7%; specificity: 40.5%). CONCLUSIONS: We developed a CPM with moderate accuracy to predict ambulatory ability outcomes in patients 3 months after surgery for trochanteric fractures. Our results demonstrate the importance of the BI score measured soon after surgery and dementia status for the prediction of postoperative ambulation.

    DOI: 10.1016/j.injury.2021.04.043

    PubMed

    researchmap

  • Reduction quality and nail fixation ratio as bone-implant stability factors associated with reoperation for trochanteric fractures. 国際誌

    Norio Yamamoto, Yosuke Tomita, Tomoyuki Noda, Tomoo Inoue, Yusuke Mochizuki, Toshifumi Ozaki

    Injury   52 ( 7 )   1813 - 1818   2021年7月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Geriatric trochanteric fractures are a major global issue, and their incidence is steadily rising. Bone quality, fracture type, fracture reduction quality, implant selection, and implant placement affect bone-implant stability in osteoporotic fractures. Our aim in this study was to evaluate the association between bone-implant stability factors, including nail construct, and the rate of reoperation in a more extensive case series with comprehensive variables. METHODS: This was a retrospective cohort study of 390 patients with trochanteric fractures aged ≥60 years and treated with intramedullary nailing. The primary outcome was the rate of reoperation due to any cause. Univariate and multivariable logistic regression analyses were used to identify factors associated with reoperation. RESULTS: In this study, 15 patients (3.8%) required reoperation. Univariate analysis showed that the following variables were significantly different between patients who required reoperation and those who did not: T-score at the total hip and lumbar spine, cortical thickness index, fracture type, and reduction quality. Multivariable logistic regression analysis showed that the odds ratio (OR) for A3 fracture type was 2.76 (95% confidence interval [CI], 0.77-9.76; p=0.116) and that for inadequate reduction, assessed by computed tomography, was 2.94 (95% CI, 0.89-9.69; p=0.076). These were independent predictors of reoperation. There was only one case (6.7%) of reoperation among patients with a distal femoral fragment fixation ratio (FR) >0.8. Considering the intraoperative decision-making process, the combination of inadequate reduction and an FR ≤0.8 were associated with the highest reoperation at a rate of 9.3% (OR, 3.327; 95% CI, 1.091-10.142; p=0.043). CONCLUSIONS: Risk factors on bone-implant stability for reoperation were the reduction quality and fracture type. Regarding the intraoperative decision-making process, the selection of a nail length with an FR >0.8 is a better option when the intramedullary reduction has been maintained intraoperatively.

    DOI: 10.1016/j.injury.2021.04.048

    PubMed

    researchmap

  • 高齢者脛骨近位部骨折の治療成績

    畑 利彰, 野田 知之, 島村 安則, 上原 健敬, 吉村 将秀, 福岡 史朗, 佐藤 浩平, 近藤 宏也, 齋藤 太一, 尾崎 敏文

    骨折   43 ( Suppl. )   S201 - S201   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 多発外傷患者における筋断面積の推移の比較

    近藤 宏也, 上原 健敬, 福岡 史朗, 佐藤 浩平, 畑 利彰, 斎藤 太一, 雑賀 建多, 島村 安則, 野田 知之, 尾崎 敏文

    骨折   43 ( Suppl. )   S371 - S371   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 関節面の整復に術中3D撮影およびナビゲーションが有用であった寛骨臼骨折の2例

    畑 利彰, 野田 知之, 島村 安則, 上原 健敬, 福岡 史朗, 佐藤 浩平, 近藤 宏也, 齋藤 太一, 雑賀 建多, 尾崎 敏文

    骨折   43 ( Suppl. )   S367 - S367   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 寛骨臼骨折手術における術中コンピュータ支援によるスクリュー挿入精度の向上

    上原 健敬, 野田 知之, 福岡 史朗, 佐藤 浩平, 畑 利彰, 近藤 宏也, 齋藤 太一, 島村 安則, 尾崎 敏文

    骨折   43 ( Suppl. )   S163 - S163   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 後方(Burks)アプローチによる脛骨近位部骨折(後外側骨片)の整復固定手技

    野田 知之, 上原 健敬, 島村 安則, 福岡 史朗, 佐藤 浩平, 畑 利彰, 近藤 宏也, 齋藤 太一, 尾崎 敏文

    骨折   43 ( Suppl. )   S90 - S90   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 大腿骨転子部骨折患者におけるCONUTを用いた術前栄養状態と術後歩行能力の関連性の検討

    佐藤 浩平, 野田 知之, 福岡 史朗, 近藤 宏也, 畑 利彰, 上原 健敬, 齋藤 太一, 島村 安則, 東原 信七郎, 尾崎 敏文

    骨折   43 ( Suppl. )   S295 - S295   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 寛骨臼骨折に対する術後臨床成績評価方法の比較 Matta scoreとJHEQの比較検討

    近藤 宏也, 上原 健敬, 福岡 史朗, 佐藤 浩平, 畑 利彰, 斎藤 太一, 雑賀 建多, 島村 安則, 野田 知之, 尾崎 敏文

    骨折   43 ( Suppl. )   S283 - S283   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 大腿骨骨幹部骨折の治療成績

    福岡 史朗, 佐藤 浩平, 畑 利彰, 近藤 宏也, 上原 健敬, 野田 知之, 尾崎 敏文

    骨折   43 ( Suppl. )   S257 - S257   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 踵骨骨折に対する外側小切開による骨接合術の治療成績 ロッキングプレート固定とスクリュー固定の比較

    佐藤 浩平, 野田 知之, 福岡 史朗, 近藤 宏也, 畑 利彰, 上原 健敬, 横尾 賢, 吉村 将秀, 尾崎 敏文

    骨折   43 ( Suppl. )   S251 - S251   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • 踵骨骨折における3DCTを用いた後距踵関節面の評価

    上原 健敬, 野田 知之, 福岡 史朗, 佐藤 浩平, 畑 利彰, 近藤 宏也, 齋藤 太一, 雑賀 建多, 島村 安則, 尾崎 敏文

    骨折   43 ( Suppl. )   S248 - S248   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本骨折治療学会  

    researchmap

  • Subjective and Objective Outcomes of Surgery for Rheumatoid Forefoot Deformities Under the Current Treatment Paradigm. 国際誌

    Masahiro Horita, Keiichiro Nishida, Daisuke Kaneda, Kenzo Hashizume, Yoshihisa Nasu, Ryuichi Nakahara, Kenta Saiga, Hideki Ohashi, Masahito Watanabe, Toshifumi Ozaki

    The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons   61 ( 1 )   53 - 59   2021年6月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We investigated the clinical outcomes of surgical procedures for the treatment of forefoot deformities in patients with rheumatoid arthritis. Twenty feet in 16 women (mean age 62.1 years) underwent corrective osteotomy of the first metatarsal bone with shortening oblique osteotomy of the lesser metatarsophalangeal joints (joint-preservation group), while 13 feet in 12 women (mean age 67.4 years) underwent arthrodesis of the first metatarsophalangeal joint with resection arthroplasty of the lesser metatarsophalangeal joints (joint-sacrifice group); mean follow-up for each group was 25.8 and 23.8 months, respectively. The mean total Japanese Society for Surgery of the Foot (JSSF) scale improved significantly from 64.2 to 89.2 in the joint-preservation group (p < .001), and from 54.2 to 74.2 in the joint-sacrifice group (p = .003). In the joint-preservation group, the postoperative range of motion (ROM) of the joint, walking ability, and activities of daily living scores of the JSSF scale were significantly higher than those in the joint-sacrifice group (p = .001, p = .001, and p = .019, respectively). There were no differences in the subscale scores of the self-administered foot evaluation questionnaire between 2 groups either pre- or postoperatively. No differences in the postoperative complications were found between 2 groups. Although the joint-sacrificing procedure resulted in lower objective outcomes than the joint-preserving procedure regarding the ROM of the joint, the walking ability, and the level of activities of daily living, both procedures resulted in similar treatment outcomes when evaluated by the subjective measures.

    DOI: 10.1053/j.jfas.2021.06.008

    PubMed

    researchmap

  • Transtibial pullout repair techniques using two simple stitches for medial meniscus posterior root tear can prevent the progression of medial meniscus extrusion and obtain successful outcomes. 国際誌

    Takaaki Hiranaka, Takayuki Furumatsu, Shinichi Miyazawa, Yuki Okazaki, Keisuke Kintaka, Yuya Kodama, Yusuke Kamatsuki, Toshifumi Ozaki

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie   2021年6月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Transtibial pullout repairs using two simple stitches (TSS) and a combination of TSS with posteromedial pullout repair (TSS + PMP) using an all-inside meniscal repair device have been reported previously for the treatment of medial meniscus (MM) posterior root tears. This study aimed to investigate the postoperative clinical outcomes of these techniques including MM extrusion (MME). METHODS: Fifty-two patients who underwent transtibial pullout repair were investigated and divided into TSS (n = 27) and TSS + PMP (n = 25) groups. The clinical outcomes were assessed using the Lysholm knee score and Knee Injury and Osteoarthritis Outcome Score 1 year postoperatively and compared between two groups. MME was measured using magnetic resonance imaging at 1 year postoperatively and compared between two groups. RESULTS: A significant improvement in each clinical score was observed in both groups, and no significant difference was seen in clinical outcomes. Moreover, no significant difference in postoperative MME was observed in both groups (TSS and TSS + PMP: 3.5 mm and 3.8 mm, respectively). Though no significant progression of MME was observed in TSS group, a significant progression of it was observed in TSS + PMP group postoperatively. CONCLUSIONS: This study demonstrated that both techniques improved clinical outcomes in the short-term postoperative period. However, MME was progressed significantly in TSS + PMP group 1 year postoperatively, which indicated that PMP might not be a useful additional procedure for reducing the postoperative MME.

    DOI: 10.1007/s00590-021-03035-8

    PubMed

    researchmap

  • Adrenergic signaling promotes the expansion of cancer stem-like cells of malignant peripheral nerve sheath tumors. 国際誌

    Rongsheng Huang, Atsushi Fujimura, Eiji Nakata, Shota Takihira, Hirofumi Inoue, Soichiro Yoshikawa, Takeshi Hiyama, Toshifumi Ozaki, Atsunori Kamiya

    Biochemical and biophysical research communications   557   199 - 205   2021年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Malignant peripheral nerve sheath tumor (MPNST), a highly malignant tumor that arises in peripheral nerve tissues, is known to be highly resistant to radiation and chemotherapy. Although there are several reports on genetic mutations and epigenetic changes that define the pathogenesis of MPNST, there is insufficient information regarding the microenvironment that contributes to the malignancy of MPNST. In the present study, we demonstrate that adrenaline increases the cancer stem cell population in MPNST. This effect is mediated by adrenaline stimulation of beta-2 adrenergic receptor (ADRB2), which activates the Hippo transducer, YAP/TAZ. Inhibition and RNAi experiments revealed that inhibition of ADRB2 attenuated the adrenaline-triggered activity of YAP/TAZ and subsequently attenuated MPNST cells stemness. Furthermore, ADRB2-YAP/TAZ axis was confirmed in the MPNST patients' specimens. The prognosis of patients with high levels of ADRB2 was found to be significantly worse. These data show that adrenaline exacerbates MPNST prognosis and may aid the development of new treatment strategies for MPNST.

    DOI: 10.1016/j.bbrc.2021.03.172

    PubMed

    researchmap

  • Clinical outcome of patients with recurrent or refractory localized Ewing's sarcoma family of tumors: A retrospective report from the Japan Ewing Sarcoma Study Group. 国際誌

    Katsutsugu Umeda, Takako Miyamura, Kenji Yamada, Hideki Sano, Ako Hosono, Minako Sumi, Hajime Okita, Tadashi Kumamoto, Akira Kawai, Junya Hirayama, Ryoji Jyoko, Akihisa Sawada, Hideki Nakayama, Yosuke Hosoya, Naoko Maeda, Nobuyuki Yamamoto, Chihaya Imai, Daiichiro Hasegawa, Motoaki Chin, Toshifumi Ozaki

    Cancer reports (Hoboken, N.J.)   4 ( 3 )   e1329   2021年6月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Patients with Ewing's sarcoma family of tumors (ESFT) who experience relapse or progression have a poor prognosis. AIM: This study aimed to identify the prognostic and therapeutic factors affecting overall survival (OS) of patients with recurrent or refractory localized ESFT. METHODS AND RESULTS: Thirty-eight patients with localized ESFT who experienced first relapse or progression between 2000 and 2018 were retrospectively reviewed. The 5-year OS rate of the entire cohort was 48.3% (95% confidence interval, 29.9%-64.5%). Multivariate analysis of OS identified time to relapse or progression, but not stem cell transplantation (SCT), as the sole independent risk factor (hazard ratio, 35.8; P = .002). Among 31 patients who received salvage chemotherapy before local treatment, 21 received chemotherapy regimens that are not conventionally used for newly diagnosed ESFT. The objective response rate to first-line salvage chemotherapy was 55.2% in the 29 evaluable patients. Time to relapse or progression was significantly associated with response to first-line salvage chemotherapy (P = .006). CONCLUSIONS: The present study fails to demonstrate significant clinical benefit of SCT for recurrent or refractory localized ESFT. Recently established chemotherapy regimens may increase the survival rate of patients with recurrent or refractory localized ESFT while attenuating the beneficial effect of SCT.

    DOI: 10.1002/cnr2.1329

    PubMed

    researchmap

  • 骨・軟部腫瘍のgermline findingsに対する遺伝子医療部門の取り組み

    二川 摩周, 中田 英二, 十川 麗美, 加藤 芙美乃, 浦川 優作, 河内 麻里子, 山本 英喜, 国定 俊之, 平沢 晃, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1251 - S1251   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • がんロコモの現状と課題 遠隔転移のないがん患者における周術期のがんロコモの発生率とそのリスクファクター

    堅山 佳美, 中田 英二, 明崎 禎輝, 千田 益生, 国定 俊之, 濱田 全紀, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1298 - S1298   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • がんロコモの現状と課題 がんロコモ発生予防のための院内システムの構築

    中田 英二, 堅山 佳美, 明崎 禎輝, 濱田 全紀, 国定 俊之, 藤原 智洋, 千田 益生, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1241 - S1241   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • DDH治療後の腸腰筋断面積の検討

    佐藤 嘉洋, 鉄永 智紀, 山田 和希, 廣瀬 一樹, 尾崎 敏文

    日本小児整形外科学会雑誌   30 ( 1 )   44 - 46   2021年6月

     詳細を見る

    担当区分:最終著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本小児整形外科学会  

    発育性股関節形成不全(以下、DDH)に対して、当院では観血的整復術(広範囲展開法:田邊法、以下、OR)の適応を保存的整復不成功例や歩行開始後の診断遅延例とし、ORで腸腰筋前方移行を行っている。本研究の目的は、腸腰筋の断面積をOR群とRiemenbuegel装具による保存的整復(以下、CR)群で比較し、ORにおける腸腰筋前方移行の影響を明らかにすることである。対象はDDH症例26例26股(女:男23:3)。OR群13例、CR群13例、CT axial viewで、S2椎間孔、臼蓋上縁、恥骨結合の各高位で腸腰筋断面積の健側に対する患側の割合(以下、%Area)を求め、OR群とCR群で比較した。結果、各高位の%Area(%)はOR群で有意に小さく、腸腰筋前方移行により長期的には腸腰筋のボリュームが低下していた。腸腰筋の機能として股関節屈曲、腰椎屈曲、側屈に加え姿勢制御がある。最終観察時に症状はなかったが、長期的には腰痛等生じる可能性はあり、注意深い経過観察が必要である。(著者抄録)

    researchmap

  • 人工知能による骨肉腫X線像読影システム

    長谷井 嬢, 中原 龍一, 板野 拓人, 沖田 駿治, 三宅 孝昌, 杉本 佳久, 木浪 陽, 藤原 一夫, 臼井 正明, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1250 - S1250   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 前腕に発生した肉腫の治療成績

    畑 利彰, 佐藤 浩平, 近藤 宏也, たき平 将太, 藤原 智洋, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1354 - S1354   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 骨肉腫における腫瘍関連マクロファージの臨床病理学的意義

    近藤 宏也, 藤原 智洋, 吉田 晶, 佐藤 浩平, 畑 利彰, たき平 将太, 中田 英二, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1410 - S1410   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫の心臓転移

    板野 拓人, 中田 英二, 国定 俊之, 藤原 智洋, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1389 - S1389   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • がん遺伝子パネルによる肉腫における融合遺伝子の検出

    佐藤 浩平, 中田 英二, 近藤 宏也, 畑 利彰, たき平 将太, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1269 - S1269   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • がんゲノム中核拠点病院における肉腫のがんゲノム医療

    中田 英二, 国定 俊之, 藤原 智洋, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1252 - S1252   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 肉腫における免疫療法

    たき平 将太, 佐藤 浩平, 畑 利彰, 近藤 宏也, 中田 英二, 藤原 智洋, 国定 俊之, 尾崎 敏文

    日本整形外科学会雑誌   95 ( 6 )   S1338 - S1338   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • 寛骨臼を含む骨盤発生Ewing肉腫に対する英国集約化施設における治療変遷とその成績

    藤原 智洋, Stevenson Jonathan, Parry Michael, 津田 祐輔, 中田 英二, 国定 俊之, 尾崎 敏文, Grimer Robert, Jeys Lee

    日本整形外科学会雑誌   95 ( 6 )   S1272 - S1272   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • NICE軟部肉腫ガイドラインは英国における軟部肉腫患者の診療体制や生存予後にどのような影響を与えたか

    藤原 智洋, Grimer Robert, Evans Scott, 津田 祐輔, 中田 英二, 国定 俊之, 尾崎 敏文, Abudu Adesegun

    日本整形外科学会雑誌   95 ( 6 )   S1371 - S1371   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

    researchmap

  • Postoperative computed tomography assessment of anteromedial cortex reduction is a predictor for reoperation after intramedullary nail fixation for pertrochanteric fractures. 国際誌

    Norio Yamamoto, Takahiro Imaizumi, Tomoyuki Noda, Tomoo Inoue, Keisuke Kawasaki, Toshifumi Ozaki

    European journal of trauma and emergency surgery : official publication of the European Trauma Society   2021年5月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Postoperative radiographs are routinely used to assess fracture reduction following intramedullary nail fixation for pertrochanteric fractures, even though computed tomography (CT) is a superior modality. We aimed to determine the association between reduction quality assessed by CT and rates of reoperation and to evaluate the association of reoperation and reduction quality according to the assessment modality (plain radiographs vs. CT). METHODS: A retrospective analysis of 299 consecutive patients treated with intramedullary nail fixation for pertrochanteric fractures was conducted. Fracture reduction measured by postoperative radiographs and CT was categorized as anatomical type, extramedullary type, or intramedullary type. Postoperative data for analysis included reduction status, tip-apex distance (TAD), screw position in the femoral head, sliding distance, and conditions associated with reoperation. RESULTS: Of the 299 patients included with a mean age of 83.1 ± 8.2 years, there were six patients who required reoperation (2.0%). According to the CT assessments, there were 42 intramedullary reductions (14.0%). Patients with a non-intramedullary reduction based on postoperative CT images were significantly more likely to have proper placement of the screw, a reduced TAD, a reduced sliding distance, and a lower reoperation rate than those with an intramedullary reduction (P < 0.05). The reduction quality assessed by postoperative CT was significantly associated with reoperation (95% CI, 1.45-29.31). CONCLUSIONS: Intramedullary reduction assessed by CT was associated with reoperation. The reduction quality based on CT findings was more predictive for reoperation than that from plain radiographs.

    DOI: 10.1007/s00068-021-01718-9

    PubMed

    researchmap

  • A newly-developed guide can create tibial tunnel at an optimal position during medial meniscus posterior root repairs.

    Takaaki Hiranaka, Takayuki Furumatsu, Yuki Okazaki, Keisuke Kintaka, Tadashi Yamawaki, Toshifumi Ozaki

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   2021年5月

     詳細を見る

    担当区分:最終著者   記述言語:英語   掲載種