Research Projects -
-
Measuring listening effort of hearing-impaired people using JINS MEME, eyewear with a sensor
Grant number：24K12673 2024.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
片岡 祐子, 勝二 博亮, 田原 敬
Grant amount：\3770000 （ Direct expense: \2900000 、 Indirect expense：\870000 ）
-
聴覚障害者の災害時・緊急時における緊急通知音振動変換装置および情報共有システムの有用性の検討
2022.04 - 2025.03
日本医療研究開発機構 障害者対策総合研究開発事業（その他） 災害時における感覚器障害者の援助要請手段と効果的な支援提供を実現する双方向連携システムの開発と社会実装にむけた効果検証
本多達也, 牧尉太, 田淵貴大, 大守伊織, 小林有美子, 日吉顕太
Authorship：Principal investigator
-
当事者ニーズに基づいた聴覚情報処置障害診断と支援の手引きの開発
2021.04 - 2024.03
日本医療研究開発機構 障害者対策総合研究開発事業（その他）
阪本浩一
Authorship：Coinvestigator(s)
-
聴覚障害者の社会参加を促進するための手法に関する研究
2020.04 - 2023.03
日本医療研究開発機構 障害者対策総合研究開発事業（その他） 聴覚障害児・者の円滑な社会参加に資する施策立案に関する研究
中川尚志
Authorship：Coinvestigator(s)
-
Usefulness of 1000 Hz tympanometry for diagnosis of middle ear infusion in Japanese infants
Grant number：26462558 2014.04 - 2017.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Kataoka Yuko, MAEDA Yukihide
Grant amount：\1820000 （ Direct expense: \1400000 、 Indirect expense：\420000 ）
Impedance audiometry of the tympanic membrane by tympanometry is an inspection method which easily detects the middle ear fluid. 226 Hz probe tone is usually used, but 1000 Hz is said to be useful in infants and it is recommended for 6-9 month-old infants who have difficulty in taking local findings. In this study, we performed 1,000 Hz and 226 Hz tympanometry at 253 ears of infants and examined the usefulness together with clinical data. The sensitivity of the 1000 Hz tympanometry was 84.6% and the specificity was 62.3%. Although the sensitivity was higher than 226 Hz, the specificity was low. For the diagnosis of exudative otitis media in infants, not only 1000 Hz tympanometry but also local findings and examination data should be considered and evaluated.
-
Grant number：25462640 2013.04 - 2016.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Maeda Yukihide, FUKUSHIMA Kunihiro, KARIYA Shin, KATAOKA Yuko
Grant amount：\3510000 （ Direct expense: \2700000 、 Indirect expense：\810000 ）
Glucocorticoids are widely used therapeutically to treat acute sensorineural hearing loss, however, molecular mechanisms of glucocorticoid action in the cochlea are largely unknown. We analyzed protein expression in cochleae of mice following administration of a potent glucocorticoid, dexamethasone by mass spectrometry. Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) approach identified 11 differentially expressed proteins by dexamethasone in the cochlea. Of these proteins, it was verified that Myelin protein zero (Mpz) and Heat shock protein 70 (Hsp 70) are differentially regulated within 12 hours following administration of dexamethasone by western blot from the cochlear sample of a mouse model of noise-induced hearing loss. Immunohistochemistry revealed Mpz is localized to the myelin sheath of the spiral neurons, whereas Hsp 70 is widely expressed in the spiral neurons, organ of Corti, spiral ligament and stria vascularis in the cochlea.
-
学習障害関連遺伝子をターゲットとした人工内耳予後予測因子に関する研究
Grant number：25462641 2013.04 - 2014.03
日本学術振興会 科学研究費助成事業 基盤研究(C)
福島 邦博, 前田 幸英, 片岡 祐子, 菅谷 明子
Grant amount：\4940000 （ Direct expense: \3800000 、 Indirect expense：\1140000 ）
小児先天性難聴に対しては、現在人工内耳埋め込み術が早期（１歳前後）から適応されることが多くなっている。しかし、人工内耳装用児のすべてが順調な言語発達を示すとは限らず、その言語発達には個人差が大きい。特に低年齢の人工内耳装用児でその言語発達予後を予測することは容易ではなく、より適切な手法の開発が望まれている。遺伝子診断は、従来難聴の原因を探すために主として用いられてきたが、近年では学習障害などの原因遺伝子も明らかにされており、この技術を用いて人工内耳術後の言語発達予後予測を行うことをこの研究の目標とした。当面、その予備実験として難聴のない言語発達障害児童（特異的言語発達障害）において、既に海外で報告されている言語発達に影響を与える遺伝子での変異の有無を検討した。末梢血から採取したDNAを用い、パラレルシークエンス法によって候補遺伝子（FOXP2,DYA1C１,DCDC2, KIAA0319, ROBO1）の全エクソンにおける変異を検討した。意味のある変異を検出することはできなかった。日本語話者での遺伝子変異は人種的ないしは言語的な違いにより、欧米での遺伝子変異とパターンが異なる可能性があり、まず本邦患者を元にした新たな言語発達障害関連遺伝子の解析が望まれると考えられた。
-
Therapeutic model for acute sensorineural hearing loss using siRNA
Grant number：22591880 2010 - 2012
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
MAEDA Yukihide, FUKUSHIMA Kunihiro, KATAOKA Yuko
Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）
The involvement of MAP kinase in noise-induced hearing loss (NIHL) has been implicated in the cochlea; however, it was unknown how expression levels of MAP kinase change after the onset of NIHL and whether they are regulated by transient phosphorylation or protein synthesis.In the data of the present study, the phospho-MEK1/ ERK/p90RSK signaling pathway was activated in the spiral ligament and the sensory and supporting cells of the organ of Corti, with peaks at 3-6 h and independently of regulations of total-MEK1/ERK/p90RSK. The expression of phospho-JNK and p38MAPK showed late upregulation in spiral neurons at 48 h, in addition to early upregulations with peaks at 3 h after noise trauma. Phospho-p38MAPK activation was dependent on upregulation of total-p38MAPK. The present data provide a significant basis for future therapeutic strategies for acute sensorineural hearing loss, including those utilizing siRNA.
-
Grant number：22791604 2010 - 2011
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
KATAOKA Yuko
Grant amount：\2860000 （ Direct expense: \2200000 、 Indirect expense：\660000 ）
Thirty children utilized "Okayama subsidizing hearing aid purchase in mild to moderate pediatric hearing" in 2010. We found in questionnaires that parents of those children think the subsidizing enables them to purchase hearing aids easier and that brings children with hearing loss to better hearing.
We examined 47 children with mild to moderate hearing loss in assessment of language development for Japanese children and analyzed it statistically. We detected that those children have significantly less number of the vocabulary in compared with normal hearing children, and those who have been wearing hearing aid longer(more than 3 years) have more number of vocabulary than no or short hearing aids users. In addition, we found that the better their hearing is, the better they understand the sentence structure. -
Genetic analysis of progressive or delayed onset hearing loss in early childhood.
Grant number：20791194 2008 - 2009
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
KATAOKA Yuko
Grant amount：\4160000 （ Direct expense: \3200000 、 Indirect expense：\960000 ）
We classified progressive or delayed onset hearing loss in the early childhood. We investigated deafness gene mutation and congenital cytomegalovirus infection of progressive or delayed onset hearing loss children, and in addition, analyzed OTOF of a child with auditory neuropathy. Some of them had enlarged vestibule aqueduct, and one of them had SLC26A4 mutation. There were children who had diagnosis of congenital cytomegalovirus infection, but someone deteriorate their hearing in early childhood without any risk factors. A case with auditory neuropathy didn't have OTOF gene mutation. We started the screening of deafness gene mutation by the invader method in our hospital in December, 2009, and we need to increase cases and investigate them more in the future.
-
Gene expression in cochlear organ culture : to find a candidate drugs for hearing loss
Grant number：19591969 2007 - 2008
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
FUKUSHIMA Kunihiro, MAEDA Yukihide, KATAOKA Yuko, KARIYA Shin, NISHIZAKI Kazunori, HIRAI Misato
Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）
感音難聴は現在までに有効な治療法が確立されていない。治療に有用な薬物を効率的に見いだすためには、内耳に作用しうる薬物をスクリーニングする手法の確立が必要である。今回我々は、内耳の器官培養を行い、難聴の治療として広く用いられているステロイドを作用させ、そこで発現する遺伝子の変化について検討した。ステロイド投与により、内耳において様々な遺伝子が発現することが示された。器官培養の系において内耳における薬理作用が検討することが可能であり、この実験系によって効果的な薬物治療戦略について検討可能であることが示された。