2021/12/16 更新

写真a

カタオカ ユウコ
片岡 祐子
KATAOKA Yuko
所属
岡山大学病院 講師
職名
講師
外部リンク

学位

  • 医学博士 ( 2002年3月   岡山大学大学院 )

研究分野

  • その他 / その他

所属学協会

▼全件表示

 

論文

  • Correction to: Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan. 国際誌

    Yoh-Ichiro Iwasa, Shin-Ya Nishio, Hidekane Yoshimura, Akiko Sugaya, Yuko Kataoka, Yukihide Maeda, Yukihiko Kanda, Kyoko Nagai, Yasushi Naito, Hiroshi Yamazaki, Tetsuo Ikezono, Han Matsuda, Masako Nakai, Risa Tona, Yuika Sakurai, Remi Motegi, Hidehiko Takeda, Marina Kobayashi, Chiharu Kihara, Takashi Ishino, Shin-Ya Morita, Satoshi Iwasaki, Masahiro Takahashi, Sakiko Furutate, Shin-Ichiro Oka, Toshinori Kubota, Yasuhiro Arai, Yumiko Kobayashi, Daisuke Kikuchi, Tomoko Shintani, Noriko Ogasawara, Yohei Honkura, Shuji Izumi, Misako Hyogo, Yuzuru Ninoyu, Mayumi Suematsu, Jun Nakayama, Nana Tsuchihashi, Mayuri Okami, Hideaki Sakata, Hiroshi Yoshihashi, Taisuke Kobayashi, Kozo Kumakawa, Tadao Yoshida, Tomoko Esaki, Shin-Ichi Usami

    Human genetics   2021年11月

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  • Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan. 国際誌

    Yoh-Ichiro Iwasa, Shin-Ya Nishio, Hidekane Yoshimura, Akiko Sugaya, Yuko Kataoka, Yukihide Maeda, Yukihiko Kanda, Kyoko Nagai, Yasushi Naito, Hiroshi Yamazaki, Tetsuo Ikezono, Han Matsuda, Masako Nakai, Risa Tona, Yuika Sakurai, Remi Motegi, Hidehiko Takeda, Marina Kobayashi, Chiharu Kihara, Takashi Ishino, Shin-Ya Morita, Satoshi Iwasaki, Masahiro Takahashi, Sakiko Furutate, Shin-Ichiro Oka, Toshinori Kubota, Yasuhiro Arai, Yumiko Kobayashi, Daisuke Kikuchi, Tomoko Shintani, Noriko Ogasawara, Yohei Honkura, Shuji Izumi, Misako Hyogo, Yuzuru Ninoyu, Mayumi Suematsu, Jun Nakayama, Nana Tsuchihashi, Mayuri Okami, Hideaki Sakata, Hiroshi Yoshihashi, Taisuke Kobayashi, Kozo Kumakawa, Tadao Yoshida, Tomoko Esaki, Shin-Ichi Usami

    Human genetics   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Mutations in the OTOF gene are a common cause of hereditary hearing loss and the main cause of auditory neuropathy spectrum disorder (ANSD). Although it is reported that most of the patients with OTOF mutations have stable, congenital or prelingual onset severe-to-profound hearing loss, some patients show atypical clinical phenotypes, and the genotype-phenotype correlation in patients with OTOF mutations is not yet fully understood. In this study, we aimed to reveal detailed clinical characteristics of OTOF-related hearing loss patients and the genotype-phenotype correlation. Detailed clinical information was available for 64 patients in our database who were diagnosed with OTOF-related hearing loss. As reported previously, most of the patients (90.6%) showed a "typical" phenotype; prelingual and severe-to-profound hearing loss. Forty-seven patients (73.4%) underwent cochlear implantation surgery and showed successful outcomes; approximately 85-90% of the patients showed a hearing level of 20-39 dB with cochlear implant and a Categories of Auditory Performance (CAP) scale level 6 or better. Although truncating mutations and p.Arg1939Gln were clearly related to severe phenotype, almost half of the patients with one or more non-truncating mutations showed mild-to-moderate hearing loss. Notably, patients with p.His513Arg, p.Ile1573Thr and p.Glu1910Lys showed "true" auditory neuropathy-like clinical characteristics. In this study, we have clarified genotype-phenotype correlation and efficacy of cochlear implantation for OTOF-related hearing loss patients in the biggest cohort studied to date. We believe that the clinical characteristics and genotype-phenotype correlation found in this study will support preoperative counseling and appropriate intervention for OTOF-related hearing loss patients.

    DOI: 10.1007/s00439-021-02351-7

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  • Effects of Protective Measures against COVID-19 on Auditory Communication for People with Hearing Loss.

    Yuko Kataoka, Yukihide Maeda, Akiko Sugaya, Ryotaro Omichi, Shin Kariya

    Acta medica Okayama   75 ( 4 )   511 - 516   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    WHO has recommended various measures to combat the COVID-19 pandemic, including mask-wearing and physical distancing. However, these changes impair communication for individuals with hearing loss. We investigated the changes in auditory communication associated with COVID-19 measures in 269 patients (male: 45.7%, female: 54.3%, median age: 54 y.o.). Most patients with hearing loss had difficulty engaging in auditory communication with people wearing masks, especially in noisy surroundings or with physical distanc-ing. These difficulties were noticeable in patients with severe hearing loss. Developing communication support strategies for people with hearing loss is an urgent need while COVID-19 measures are in place.

    DOI: 10.18926/AMO/62404

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  • Supraglottic subepithelial benign mass lesions: Focus on clinical features of sialolipoma-like lesion. 国際誌

    Tomoyasu Tachibana, Shin Kariya, Yoji Wani, Yasutoshi Komatsubara, Yuto Naoi, Kazunori Kuroda, Soichiro Fushimi, Machiko Hotta, Katsuya Haruna, Tami Nagatani, Takuma Makino, Yuko Kataoka, Kazunori Nishizaki

    Auris, nasus, larynx   48 ( 1 )   154 - 160   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Sialolipoma has been classified as a benign soft tissue lesion in the 2017 World Health Organization classification of head and neck tumors. To our knowledge, only one case of laryngeal sialolipoma has been reported in the English literature. We conducted a retrospective study to identify clinical characteristics of supraglottic sialolipoma-like lesion and differentiate it from other supraglottic subepithelial masses. METHODS: Medical records of 16 patients with supraglottic subepithelial benign mass lesions who underwent histological evaluation between 2003 and 2019 were retrospectively analyzed. Sialolipoma-like lesion was defined as a local finding of a well-circumscribed gross mass with pathological presence of salivary gland-like parenchymal lobules with evenly interspersed adipose tissue. RESULTS: Eight patients showed histological positivity for sialolipoma-like lesion, 3 for amyloidosis, 2 for hemangioma, and 1 each for cyst, lymphoid hyperplasia, and chondrometaplasia. Sialolipoma-like lesion tended to be predominant among men; those affected had a mean age of 52.8 (range, 39-74) years. By contrast, among patients with amyloidosis, the ratio of men to women was 1:2 (100% vs. 33%; p = 0.055). Fiberscopic examination of all patients with sialolipoma-like lesions identified well-circumscribed, yellowish masses, closely resembling local amyloidosis findings. Sialolipoma-like lesion was associated with a significantly higher body-mass index (BMI; 27.4 ± 2.8 kg/m2) than amyloidosis (21.6 ± 1.4 kg/m2; p = 0.014). The transoral approach was used for lesion resection in all patients with sialolipoma-like lesion. No patient experienced postoperative recurrence. CONCLUSION: Laryngeal sialolipoma-like lesion might be more prevalent than was previously reported, and histological examination is important to differentiate it from amyloidosis. Supraglottic sialolipoma-like lesion must be differentially diagnosed in patients with high BMI presenting with well-circumscribed, yellowish supraglottic masses.

    DOI: 10.1016/j.anl.2020.07.017

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  • 軽度~中等度難聴児への対応と課題 思春期に学校生活で抱える問題

    片岡祐子

    小児耳鼻咽喉科   42 ( 1 )   2021年

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  • 両側難聴児・者が学校生活で抱える問題に関する調査の検討

    片岡祐子, 菅谷明子, 中川敦子, 田中里実, 問田直美, 福島邦博, 前田幸英, 假谷伸

    Audiology Japan   64 ( 1 )   2021年

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  • Prevalence and risk factors for delayed-onset hearing loss in early childhood: A population-based observational study in Okayama Prefecture, Japan. 国際誌

    Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Akiko Sugaya, Akiko Shigehara, Shin Kariya, Kazunori Nishizaki

    International journal of pediatric otorhinolaryngology   138   110298 - 110298   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: The aim of this study was to retrospectively document prevalence rates of delayed-onset hearing loss (DOHL) under 7 years old after passing the newborn hearing screening (NHS) program using its database in Okayama Prefecture, as well as records from Okayama Kanariya Gakuen (OKG, Auditory Center for Hearing Impaired Children, Okayama Prefecture, Japan). We explored the percentage of children with DOHL among all children who underwent the NHS and surveyed risk factors abstracted from their clinical records. METHODS: We collected data of 1171 children, who first visited OKG from April 2006 to March 2018. DOHL children were defined as bilaterally hearing-impaired children who were diagnosed under 7 years old after passing the NHS at birth. Based on the medical records, we investigated age at diagnosis, hearing levels, and risk factors. As population-based data of 168,104 children, the percentage of DOHL subjects was retrospectively calculated among the total number of children who underwent the NHS in Okayama Prefecture from April 2005 to March 2017. RESULTS: During the period, we identified 96 children with bilateral DOHL, of which 34 children had failed the NHS unilaterally and 62 had passed the NHS bilaterally. Among all children who underwent the NHS in Okayama Prefecture, the prevalence rate of DOHL in unilaterally referred infants was 5.2%, and 0.037% in bilaterally passed children. The prevalence of bilateral DOHL was 0.057% overall. Unilaterally referred children with DOHL were diagnosed at an average of 13.9 months, while bilaterally passed children with DOHL were diagnosed at an average of 42.3 months. Approximately 59.4% of children with DOHL had risk factors, among which family history of hearing loss was the most frequent. CONCLUSION: We propose the first English report of DOHL prevalence in the prefecture population in Japann, which is among the largest community-based population ever reported. The NHS is not a perfect strategy to detect all early-childhood hearing loss; therefore, careful assessment of hearing throughout childhood is recommended, especially in children with risk factors of hearing loss. Further interventional strategies must be established, such as regular hearing screening in high-risk children and assessments of hearing and speech/language development in public communities and nursery schools.

    DOI: 10.1016/j.ijporl.2020.110298

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  • Clinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglottic cancer. 国際誌

    Yasutoshi Komatsubara, Tomoyasu Tachibana, Yorihisa Orita, Takuma Makino, Kazunori Kuroda, Yuto Naoi, Yuko Kataoka, Yasuharu Sato, Shin Kariya, Kazunori Nishizaki

    Acta oto-laryngologica   140 ( 9 )   773 - 778   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics of SGC have not been well characterized.Objectives: In the current study, SGCs were clinically evaluated, and the outcomes of radiotherapy (RT) in patients with stage II SGC were assessed.Materials and Methods: Medical data derived from 11 patients with SGC, who were treated at our hospital between 1995 and 2019, were retrospectively reviewed.Results: In our department SGC accounted for 3.9% of the 280 laryngeal cancer patients treated during the study period. At the time of SGC diagnosis, 9 (81.8%) had stage II cancer, 1 had stage III cancer, and 1 had stage IV cancer. Stage II SGC patients treated with concurrent chemoradiotherapy (CCRT) showed a significantly higher local control rate (p = .026) and laryngeal dysfunction free rate (p = .026) than those treated with RT alone. Salvage surgery, performed in 4 patients whose disease was not locally controlled with CCRT/RT, was successful in 3 patients.Conclusion: As a treatment strategy for stage II SGC, CCRT is an acceptable initial treatment for laryngeal function and preservation while salvage surgery is effective for recurrence after CCRT/RT treatment.

    DOI: 10.1080/00016489.2020.1767303

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  • Role of Macrophage Migration Inhibitory Factor in NLRP3 Inflammasome Expression in Otitis Media. 国際誌

    Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yukihide Maeda, Yuko Kataoka, Takaya Higaki, Seiichiro Makihara, Jun Nishihira, Tomoyasu Tachibana, Kazunori Nishizaki

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   41 ( 3 )   364 - 370   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    HYPOTHESIS: Macrophage migration inhibitory factor plays an important role in the expression of interleukin (IL)-1β and the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in lipopolysaccharide-induced otitis media. BACKGROUND: NLRP3 inflammasome and macrophage migration inhibitory factor are critical molecules mediating inflammation. However, the interaction between the NLRP3 inflammasome and macrophage migration inhibitory factor has not been fully examined. METHODS: Wild-type mice and macrophage migration inhibitory factor gene-deficient (MIF) mice received a transtympanic injection of either lipopolysaccharide or phosphate-buffered saline. The mice were sacrificed 24 hours after the injection. Concentrations of IL-1β, NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in the middle ear effusions were measured by enzyme-linked immunosorbent assay. Temporal bones were processed for histologic examination and immunohistochemistry. RESULTS: In the immunohistochemical study using the wild-type mice, positive staining of macrophage migration inhibitory factor, NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells induced by lipopolysaccharide in the middle ear. The number of inflammatory cells caused by lipopolysaccharide administration decreased remarkably in the MIF mice as compared with the wild-type mice. The concentrations of IL-1β, NLRP3, ASC, and caspase-1 increased in the lipopolysaccharide-treated wild-type mice. The MIF mice with lipopolysaccharide had decreased levels of IL-1β, NLRP3, ASC, and caspase-1 as compared with the wild-type mice. CONCLUSION: Macrophage migration inhibitory factor has an important role in the production of IL-1β and the NLRP3 inflammasome. Controlling the inflammation by modulating macrophage migration inhibitory factor and the NLRP3 inflammasome may be a novel therapeutic strategy for otitis media.

    DOI: 10.1097/MAO.0000000000002537

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  • 「軽度~中等度難聴児への対応と課題」思春期に学校生活で抱える問題

    片岡祐子

    小児耳鼻咽喉科   41 ( 2 )   2020年

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  • 課題山積のわが国の乳幼児健診 先天性聴覚障害

    片岡祐子

    日本医師会雑誌   149 ( 4 )   2020年

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  • 身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究 インクルーシブ教育を受ける思春期の難聴者の抱える問題に関する研究

    西崎和則, 片岡祐子, 菅谷明子

    身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究 令和元年度 総括・分担研究報告書(Web)   2020年

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  • Progression of hearing loss and choice of hearing aids by patients in their 60s, 70s, and 80s and older: experience in the Japanese super-aged era. 国際誌

    Yukihide Maeda, Shin Kariya, Shohei Fujimoto, Akiko Sugaya, Yuko Kataoka, Atsuko Nakagawa, Satomi Tanaka, Natsumi Hosokawa, Kazunori Nishizaki

    Acta oto-laryngologica   139 ( 12 )   1077 - 1082   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Demographic data of patients with sensorineural hearing loss (SNHL) in super-aged societies are still limited.Aims/objectives: To report audiometric statistics of SNHL and hearing aid (HA) use in patients in their 60s, 70s, and 80s and older during the super-aged era.Material and methods: Medical charts and audiograms of 2064 older patients with SNHL who visited a Japanese University Hospital in 2007-2018 were retrospectively reviewed. Among 270 patients referred to the HA service unit (HASU), the percentage of final decisions to continue using HAs was calculated.Results: The average pure tone thresholds on initial visit to the clinic were 56.9, 60.6, 69.4, and 82.4 dB HL in patients in their 60s, 70s, 80s, and 90s, respectively. The rates of progression were 0.25, 0.87, 1.19, and 1.37 dB/year in patients in their 50s, 60s, 70s, and 80s, respectively. The percentage of patients in HASU who chose to use HAs did not differ among the 60s (59.3%), 70s (51.2%), and 80s and older (58.2%).Conclusions and significance: The clinical picture of patients with SNHL in their 70s and 80s differs because progression accelerates exponentially through these ages. HAs can be recommended to older adult patients in all the age groups.

    DOI: 10.1080/00016489.2019.1667531

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  • Impact of reading and writing skills on academic achievement among school-aged hearing-impaired children. 国際誌

    Akiko Sugaya, Kunihiro Fukushima, Soshi Takao, Norio Kasai, Yukihide Maeda, Akie Fujiyoshi, Yuko Kataoka, Shin Kariya, Kazunori Nishizaki

    International journal of pediatric otorhinolaryngology   126   109619 - 109619   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Reading and writing skills are important for hearing-impaired children since these skills help them to develop their language skills, but the prevalence of reading/writing difficulties and its effects on language development aspects among them are unclear. In this study, we identified language development features and demographic factors of Japanese hearing-impaired children diagnosed as having reading/writing difficulties. METHODS: We analyzed data from a total of 546 sever-to-profound pre-school and elementary school hearing-impaired children for this study. Children with reading/writing difficulties (Group A) were defined as children obtaining low scores (-1.5 SD compared to others in the same grade) in the Screening Test of Reading and Writing for Japanese Primary School Children (STRAW), and we compared other language development features (communication ability, vocabulary, syntax and academic achievement) and demographic factors to those of hearing-impaired children with normal reading and writing skills (Group B). We assessed language development domains as outcomes using the Assessment of Language Development for Japanese Children (ALADJIN) package, and analyzed the results stratified by age groups (5-6, 7-8, 9-10, and 11-12 years) using multiple regression analyses. RESULTS: The prevalence of reading/writing difficulties was 20.1% among the participants. Almost all point estimates in each language development domain showed better odds ratios (OR) except Criterion Referenced Test -II (CRT-II) mathematics in 11- to 12-year-olds in fully-adjusted models. Among 9- to 10-year-olds, the ORs (95% confidence interval) for fair academic achievement measured by CRT-II were 2.60 (1.09-6.20) for Japanese and 3.02 (1.29-7.11) for mathematics in Group B, even after adjusting for possible confounding factors. CONCLUSIONS: Reading and writing are important for language development of hearing-impaired children, especially for academic achievement during the middle phase of elementary school. Screening for reading/writing difficulties is important for appropriate intervention and to prevent language and academic delays among hearing-impaired children.

    DOI: 10.1016/j.ijporl.2019.109619

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  • Comprehensive analysis of syndromic hearing loss patients in Japan. 国際誌

    Michie Ideura, Shin-Ya Nishio, Hideaki Moteki, Yutaka Takumi, Maiko Miyagawa, Teruyuki Sato, Yumiko Kobayashi, Kenji Ohyama, Kiyoshi Oda, Takamichi Matsui, Tsukasa Ito, Hiroshi Suzumura, Kyoko Nagai, Shuji Izumi, Nobuhiro Nishiyama, Manabu Komori, Kozo Kumakawa, Hidehiko Takeda, Yoko Kishimoto, Satoshi Iwasaki, Sakiko Furutate, Kotaro Ishikawa, Masato Fujioka, Hiroshi Nakanishi, Jun Nakayama, Rie Horie, Yumi Ohta, Yasushi Naito, Mariko Kakudo, Hirofumi Sakaguchi, Yuko Kataoka, Kazuma Sugahara, Naohito Hato, Takashi Nakagawa, Nana Tsuchihashi, Yukihiko Kanda, Chiharu Kihara, Tetsuya Tono, Ikuyo Miyanohara, Akira Ganaha, Shin-Ichi Usami

    Scientific reports   9 ( 1 )   11976 - 11976   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    More than 400 syndromes associated with hearing loss and other symptoms have been described, corresponding to 30% of cases of hereditary hearing loss. In this study we aimed to clarify the mutation spectrum of syndromic hearing loss patients in Japan by using next-generation sequencing analysis with a multiple syndromic targeted resequencing panel (36 target genes). We analyzed single nucleotide variants, small insertions, deletions and copy number variations in the target genes. We enrolled 140 patients with any of 14 syndromes (BOR syndrome, Waardenburg syndrome, osteogenesis imperfecta, spondyloepiphyseal dysplasia congenita, Stickler syndrome, CHARGE syndrome, Jervell and Lange-Nielsen syndrome, Pendred syndrome, Klippel-Feil syndrome, Alport syndrome, Norrie disease, Treacher-Collins syndrome, Perrault syndrome and auditory neuropathy with optic atrophy) and identified the causative variants in 56% of the patients. This analysis could identify the causative variants in syndromic hearing loss patients in a short time with a high diagnostic rate. In addition, it was useful for the analysis of the cases who only partially fulfilled the diagnostic criteria.

    DOI: 10.1038/s41598-019-47141-4

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  • OTOF mutation analysis with massively parallel DNA sequencing in 2,265 Japanese sensorineural hearing loss patients. 国際誌

    Yoh-Ichiro Iwasa, Shin-Ya Nishio, Akiko Sugaya, Yuko Kataoka, Yukihiko Kanda, Mirei Taniguchi, Kyoko Nagai, Yasushi Naito, Tetsuo Ikezono, Rie Horie, Yuika Sakurai, Rina Matsuoka, Hidehiko Takeda, Satoko Abe, Chiharu Kihara, Takashi Ishino, Shin-Ya Morita, Satoshi Iwasaki, Masahiro Takahashi, Tsukasa Ito, Yasuhiro Arai, Shin-Ichi Usami

    PloS one   14 ( 5 )   e0215932   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The OTOF gene (Locus: DFNB9), encoding otoferlin, is reported to be one of the major causes of non-syndromic recessive sensorineural hearing loss, and is also reported to be the most common cause of non-syndromic recessive auditory neuropathy spectrum disorder (ANSD). In the present study, we performed OTOF mutation analysis using massively parallel DNA sequencing (MPS). The purpose of this study was to reveal the frequency and precise genetic and clinical background of OTOF-related hearing loss in a large hearing loss population. A total of 2,265 Japanese sensorineural hearing loss (SNHL) patients compatible with autosomal recessive inheritance (including sporadic cases) from 53 otorhinolaryngology departments nationwide participated in this study. The mutation analysis of 68 genes, including the OTOF gene, reported to cause non-syndromic hearing loss was performed using MPS. Thirty-nine out of the 2,265 patients (1.72%) carried homozygous or compound heterozygous mutations in the OTOF gene. It is assumed that the frequency of hearing loss associated with OTOF mutations is about 1.72% of autosomal recessive or sporadic SNHL cases. Hearing level information was available for 32 of 39 patients with biallelic OTOF mutations; 24 of them (75.0%) showed profound hearing loss, 7 (21.9%) showed severe hearing loss and 1 (3.1%) showed mild hearing loss. The hearing level of patients with biallelic OTOF mutations in this study was mostly severe to profound, which is consistent with the results of past reports. Eleven of the 39 patients with biallelic OTOF mutations had been diagnosed with ANSD. The genetic diagnosis of OTOF mutations has significant benefits in terms of clinical decision-making. Patients with OTOF mutations would be good candidates for cochlear implantation; therefore, the detection of OTOF mutations is quite beneficial for patients, especially for those with ANSD.

    DOI: 10.1371/journal.pone.0215932

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  • 新生児聴覚スクリーニングの現状と今後の課題

    片岡祐子

    日本耳鼻咽喉科学会会報   122 ( 12 )   2019年

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  • 小児科医に求められる新生児医療の基本 新生児室で行われる検査の意義と実際 新生児聴覚スクリーニング

    片岡祐子

    小児内科   51 ( 5 )   2019年

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  • 難治性聴覚障害に関する調査研究 当科で経験したWFS1遺伝子変異による若年発症型両側性感音難聴の2家系例

    西崎和則, 片岡祐子, 前田幸英, 菅谷明子

    難治性聴覚障害に関する調査研究 平成30年度 総括・分担研究報告書(Web)   2019年

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  • 「新生児聴覚スクリーニングがもたらすもの」

    片岡祐子

    三重医報   ( 709 )   2019年

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  • 乳幼児滲出性中耳炎診断における 1,000Hz ティンパノメトリーの有用性の検討

    片岡祐子, 前田幸英, 藤澤郁, 菅谷明子, 假谷伸, 西崎和則

    日本耳鼻咽喉科学会会報   122 ( 7 )   2019年

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  • 身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究「遅発性難聴の早期発見」「思春期の難聴児が抱える問題の検証」に関する研究

    西崎和則, 片岡祐子, 菅谷明子

    身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究 平成30年度 総括・分担研究報告書(Web)   2019年

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  • NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media. 国際誌

    Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yukihide Maeda, Yuko Kataoka, Takaya Higaki, Yohei Noda, Seiichiro Makihara, Kazunori Nishizaki

    Acta oto-laryngologica   138 ( 12 )   1061 - 1065   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is a critical molecule mediating interleukin-1β (IL-1β) responses. However, the role of the NLRP3 inflammasome in otitis media has not been fully examined. AIMS/OBJECTIVES: The purpose of this study is to assess the expression of NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in lipopolysaccharide-induced otitis media. MATERIALS AND METHODS: BALB/c mice received a transtympanic injection of either lipopolysaccharide or phosphate-buffered saline. The mice were sacrificed 24 h after injection. Concentrations of IL-1β, NLRP3, ASC, and caspase-1 in the middle ear effusions were measured by enzyme-linked immunosorbent assay. Temporal bones were processed for histologic examination and immunohistochemistry. RESULTS: The transtympanic injection of lipopolysaccharide significantly upregulated levels of IL-1β, NLRP3, ASC, and caspase-1 in the middle ear as compared with the control mice. The proteins of NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells induced by lipopolysaccharide in the middle ear cavity. CONCLUSIONS AND SIGNIFICANCE: Lipopolysaccharide induces NLRP3 inflammasome components in the middle ear. The NLRP3 inflammasome may play an important role in the pathogenesis of otitis media. Modulation of inflammasome-mediated inflammation may be a novel therapeutic strategy for otitis media.

    DOI: 10.1080/00016489.2018.1515499

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  • Relationship between pure-tone audiogram findings and speech perception among older Japanese persons. 国際誌

    Yukihide Maeda, Soshi Takao, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Satomi Tanaka, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

    Acta oto-laryngologica   138 ( 2 )   140 - 144   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To clarify how the pure-tone threshold (PTT) on the PTA predicts speech perception (SP) in elderly Japanese persons. METHODS: Data on PTT and SP were cross-sectionally analyzed in Japanese persons (656 ears in 353 patients, aged ≥65 years). Correlations of SP and average PTT in all tested frequencies were evaluated by Pearson's correlation coefficient and simple linear regression. After adjusting for sex, laterality of ears, and age, the relationship of average and frequency-specific PTT with impaired SP ≤50% was estimated by logistic regression models. RESULTS: SP correlated well (r = -0.699) with the average PTT of all tested frequencies. On the other hand, the correlation between patient age and SP was weak, especially among ≤85-year-old persons (r = -0.092). Linear regression showed that the average PTT corresponding to SP of 50% was 76.4 dB nHL. Odds ratios for impaired SP were highest for PTT at 2000 Hz. Odds ratios were higher for middle (500, 1000, 2000 Hz) and high frequencies (4000, 8000 Hz) than low frequencies (125, 250 Hz). CONCLUSION: The PTT on the pure-tone audiogram (PTA) is a good predictor of SP by speech audiometry among older persons, which could provide clinically important information for hearing aid fitting and cochlear implantation.

    DOI: 10.1080/00016489.2017.1378435

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  • 次世代シークエンサーを併用した難聴の遺伝学的検査が有用であった小児難聴の3例

    菅谷明子, 菅谷明子, 片岡祐子, 片岡祐子, 峠和美, 假谷伸, 前田幸英, 大道亮太郎, 佐藤吏江, 西崎和則

    日本遺伝カウンセリング学会誌   39 ( 3 )   2018年

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  • ビスホスホネート製剤投与が原因と考えられた外耳道骨壊死

    片岡祐子, 野田実里, 大道亮太郎, 清水藍子, 假谷伸, 西崎和則

    日本耳鼻咽喉科学会会報   121 ( 7 )   2018年

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  • 骨吸収抑制薬関連顎骨壊死

    片岡祐子

    岡山医学会雑誌   130 ( 2 )   2018年

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  • How to Follow-up Q&A-2018アップデート 予後 聴力のフォローアップ:スクリーニングと聴覚予後

    御牧信義, 片岡祐子

    周産期医学   48 ( 9 )   2018年

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  • 新生児聴覚スクリーニングの費用対効果の検討

    片岡祐子, 菅谷明子, 福島邦博, 前田幸英, 假谷伸, 西崎和則

    日本耳鼻咽喉科学会会報   121 ( 10 )   2018年

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  • Genetic Counseling of a Hearing-impaired Patient with Multiple Genetic Mutations.

    Yuko Kataoka, Akiko Sugaya, Yukihide Maeda, Shin Kariya, Ryotaro Omichi, Kunihiro Fukushima, Kazunori Nishizaki

    Nihon Jibiinkoka Gakkai kaiho   120 ( 2 )   131 - 6   2017年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Since April 2012, genetic testing for congenital hearing loss is covered by the public health insurance in Japan. Recent (since August 2015) developments in next-generation sequencing technology have enabled the detection of 154 mutations in 19 genes. Genetic testing provides valuable information on hearing phenotype, prognosis, and prediction of associated symptoms. We report a hearing-impaired patient in whom multiple genetic mutations were detected. This patient carries two missense mutations in GJB2 (p.G45E, p.Y136X), as well as a mitochondrial mutation (7445A>G). Since the number of genes detectable by genetic testing has increased, the diagnosis of hearing loss can be made with greater accuracy. However, it is often difficult to clinically understand and interpret the genotype information, especially when multiple gene variants are detected in one patient or family. Genetic counseling plays an important part in the intervention for or follow-up of such patients. Genotypic and phenotypic information of other family members is necessary, so that both the patient and the family can understand and accept the results of genetic testing.

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  • MRI 検査後に人工内耳インプラント磁石の反転を来した2症例

    片岡祐子, 内藤智之, 假谷伸, 菅谷明子, 前田幸英, 福島邦博, 西崎和則

    日本耳鼻咽喉科学会会報   120 ( 5 )   2017年

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  • 複数の遺伝子ヴァリアントを有する難聴者における遺伝カウンセリング経験

    片岡祐子, 菅谷明子, 前田幸英, 假谷伸, 大道亮太郎, 福島邦博, 西崎和則

    日本耳鼻咽喉科学会会報   120 ( 2 )   2017年

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  • Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy. 国際誌

    Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Rie Nagayasu, Atsuko Nakagawa, Toru Yamashita, Koji Abe, Kazunori Nishizaki

    Acta oto-laryngologica   136 ( 3 )   266 - 70   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    CONCLUSION: The prevalence of low-tone hearing loss (LTHL) is significantly high in spinocerebellar degeneration (SCD) with cerebellar predominance, including multiple-system atrophy C (MSA-C) and cortical cerebellar atrophy (CCA). OBJECTIVE: This study aimed to test the hypothesis that SCD with cerebellar predominance, MSA-C and CCA may cause auditory symptoms. METHODS: The shape and threshold of pure-tone audiograms were evaluated for MSA-C (n = 47; mean (± SD) age, 61.6 ± 8.9 years), CCA (n = 16; 62.8 ± 9.5 years), and age-matched controls (n = 169; 62.5 ± 10.7 years). To differentiate specific hearing loss for MSA-C and CCA from presbycusis, the shape of audiograms was examined based on previously established audiological criteria. RESULTS: When audiogram shape was defined according to audiological criteria, the odds ratio for LTHL in SCD compared to controls was 2.492 (95% confidence interval (CI) = 1.208-5.139; p < 0.05, Pearson's Chi-square test) in MSA-C and 2.194 (95% CI = 0.709-6.795) in CCA. When the selection of audiogram shape according to these criteria was verified by three certified audiologists, odds ratios for LTHL in MSA-C and CCA were 3.243 (95% CI = 1.320-7.969) and 3.692 (95% CI = 1.052-12.957), respectively, significantly higher than in controls.

    DOI: 10.3109/00016489.2015.1104722

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  • Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media. 国際誌

    Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yuko Kataoka, Junko Yoshinobu, Yukihide Maeda, Hisashi Ishihara, Takaya Higaki, Kazunori Nishizaki

    Acta oto-laryngologica   136 ( 2 )   136 - 40   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    CONCLUSIONS: The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays an important role in the pathogenesis of middle ear diseases. Modulation of inflammasome-mediated inflammation may be a novel therapeutic strategy for cholesteatoma and chronic otitis media. OBJECTIVE: NLRP3 inflammasome is a critical molecule mediating interleukin (IL)-1β responses. However, the expression of NLRP3 in the pathogenesis of cholesteatoma and chronic otitis media has not been fully examined. This study sought to assess the expression of NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in middle ear tissues in patients with cholesteatoma or chronic otitis media. METHODS: Middle ear tissue samples were obtained from patients with cholesteatoma or chronic otitis media. Control middle ear samples were collected during cochlear implant surgery of patients without middle ear inflammation. The expression of NLRP3, ASC, and caspase-1 were examined by reverse transcription polymerase chain reaction (RT-PCR) assay and immunohistochemical study. RESULTS: The levels of mRNA of NLRP3, ASC, and caspase-1 were significantly elevated in cholesteatoma and chronic otitis media as compared with that of normal controls. The proteins of NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells in cholesteatoma and chronic otitis media.

    DOI: 10.3109/00016489.2015.1093171

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  • 人工内耳装用児のスポーツに関するアンケート調査

    片岡祐子, 菅谷明子, 假谷伸, 大道亮太郎, 前田幸英, 福島邦博, 西崎和則

    Otology Japan   26 ( 3 )   2016年

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  • 当科における小児両側人工内耳50例の検討

    長安吏江, 菅谷明子, 假谷伸, 福島邦博, 福島邦博, 片岡祐子, 前田幸英, 大道亮太郎, 西崎和則

    小児耳鼻咽喉科   37 ( 1 )   2016年

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  • 海水浴後に罹患したShewanella putrefaciensによる中耳感染症の例

    藤本将平, 片岡祐子, 假谷伸, 菅谷明子, 西崎和則

    日本耳鼻咽喉科感染症・エアロゾル学会会誌   4 ( 1 )   2016年

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  • Impact of early intervention on comprehensive language and academic achievement in Japanese hearing-impaired children with cochlear implants. 国際誌

    Akiko Sugaya, Kunihiro Fukushima, Norio Kasai, Yuko Kataoka, Yukihide Maeda, Rie Nagayasu, Naomi Toida, Shyuhei Ohmori, Akie Fujiyoshi, Tomoko Taguchi, Ryotaro Omichi, Kazunori Nishizaki

    International journal of pediatric otorhinolaryngology   79 ( 12 )   2142 - 6   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Early hearing detection and intervention (EHDI) is critical for achievement of age-appropriate speech perception and language development in hearing-impaired children. It has been 15 years since newborn hearing screening (NHS) was introduced in Japan, and its effectiveness for language development in hearing-impaired children has been extensively studied. Moreover, after over 20 years of cochlear implantation in Japan, many of the prelingual cochlear implant (CI) users have reached school age, and the effect of CI on language development have also been assessed. To identify prognostic factors for language development, audiological/language test scores and demographic factors were compared among prelingual severe-to-profound hearing-impaired children with CI divided into subgroups according to age at first hearing aid (HA) use and whether they received NHS. METHODS: Prelingual severe-to-profound deafened children from the Research on Sensory and Communicative Disorders (RSCD) project who met the inclusion criteria were divided into groups according to the age (in months) of HA commencement (before 6 months: group A, after 7 months: group B), and the presence or absence of NHS (groups C and D). Language development and socio-economic data were obtained from audiological/language tests and a questionnaire completed by caregivers, respectively. RESULTS: In total, 210 children from the RSCD project participated in this study. Group A (n=49) showed significantly higher scores on comprehensive vocabulary and academic achievement (p<0.05) than group B (n=161), with no difference in demographics except for significantly older age in group B. No differences in language scores were observed between group C (n=71) and group D (n=129), although participants of group D was significantly older and had used CIs longer (p<0.05). CONCLUSIONS: Early use of HAs until the CI operation may result in better language perception and academic achievement among CI users with prelingual deafness. A long-term follow-up is required to assess the usefulness of NHS for language development.

    DOI: 10.1016/j.ijporl.2015.09.036

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  • Steroid-dependent sensorineural hearing loss in a patient with Charcot-Marie-Tooth disease showing auditory neuropathy. 国際誌

    Yukihide Maeda, Yuko Kataoka, Akiko Sugaya, Shin Kariya, Katsuhiro Kobayashi, Kazunori Nishizaki

    Auris, nasus, larynx   42 ( 3 )   249 - 53   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Charcot-Marie-Tooth disease (CMT) is the most common form of hereditary sensorimotor neuropathy and sometimes involves disorders of the peripheral auditory system. We present a case of steroid-dependent auditory neuropathy associated with CMT, in which the patient experienced 3 episodes of acute exacerbation of hearing loss and successful rescue of hearing by prednisolone. An 8-year-old boy was referred to the otolaryngology department at the University Hospital. He had been diagnosed with CMT type 1 (demyelinating type) at the Child Neurology Department and was suffering from mild hearing loss due to auditory neuropathy. An audiological diagnosis of auditory neuropathy was confirmed by auditory brainstem response and distortion-product otoacoustic emissions. At 9 years and 0 months old, 9 years and 2 months old, and 10 years and 0 months old, he had experienced acute exacerbations of hearing loss, each of which was successfully rescued by intravenous or oral prednisolone within 2 weeks. Steroid-responsive cases of CMT have been reported, but this is the first case report of steroid-responsive sensorineural hearing loss in CMT. The present case may have implications for the mechanisms of action of glucocorticoids in the treatment of sensorineural hearing loss.

    DOI: 10.1016/j.anl.2014.11.002

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  • Does the introduction of newborn hearing screening improve vocabulary development in hearing-impaired children? A population-based study in Japan. 国際誌

    Shuhei Ohmori, Akiko Sugaya, Naomi Toida, Etsuji Suzuki, Masato Izutsu, Tomoko Tsutsui, Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Kazunori Nishizaki

    International journal of pediatric otorhinolaryngology   79 ( 2 )   196 - 201   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Permanent hearing impairment has a life-long impact on children and its early identification is important for language development. A newborn hearing screening (NHS) program has started in Okayama Prefecture, Japan, in 1999 to detect hearing impairment immediately after birth. We aim to examine the effect of this screening program on vocabulary development in pre-school children in a before and after comparative study design. METHODS: A total of 107 5-year-old children who graduated from Okayama Kanariya Gakuen (an auditory center for hearing-impaired children) between 1998 and 2011 were enrolled in this study. The pre-NHS group (n=40) was defined as those who graduated between 1998 and 2003, while the post-NHS group (n=67) was defined as those who graduated between 2004 and 2011. The primary outcome was receptive vocabulary, which was assessed by the Picture Vocabulary Test [score <18 (low) vs. score ≥18 (high)]. The secondary outcome was productive vocabulary, or the number of productive words, which was assessed by an original checklist [<1773 words (low) vs. ≥1773 (high)]. We calculated odds ratios and 95% confidence intervals for vocabulary development and compared both groups. RESULTS: The adjusted Picture Vocabulary Test score and number of productive words were significantly higher (p<0.01) in the post-NHS group than the pre-NHS group. Odds ratios were 2.63 (95% confidence interval: 1.17-5.89) for receptive vocabulary and 4.17 (95% confidence interval: 1.69-10.29) for productive vocabulary. CONCLUSIONS: The introduction of NHS in Okayama Prefecture significantly improved both receptive and productive vocabulary development in hearing-impaired children.

    DOI: 10.1016/j.ijporl.2014.12.006

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  • Outcomes of consonant-vowel monosyllable perception and word recognition after cochlear implantation in elderly Japanese patients. 国際誌

    Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Kunihiro Fukushima, Kazunori Nishizaki

    Acta oto-laryngologica   135 ( 11 )   1108 - 12   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    CONCLUSION: Performance in consonant-vowel (CV) monosyllable speech perception after cochlear implantation (CI) in the elderly (≥ 65 years) is equivalent to that of young adults (18-64 years). Present data in the Japanese language supported the indication for CI in the elderly. Word recognition after CI was significantly lower in the elderly than young adults. OBJECTIVE: This study compared outcomes of monosyllable perception and word recognition after CI between elderly patients and young adults with post-lingual deafness. Age-related differences in CV monosyllable speech perception in Japanese were examined. METHODS: A retrospective chart review of 137 patients with post-lingual deafness who underwent CI at Okayama University Hospital during 1992-2014 [young adults aged 18-64 years (n = 96) and elderly aged ≥ 65 years (n = 41) at implantation] was conducted. CV monosyllable speech perception post-CI was compared among age groups (18-29, 30-39, 40-49, 50-59, 60-69, 70-79, 80-89). CV monosyllable perception and word recognition scores post-CI were compared between the elderly and young adults. RESULTS: There was no significant difference in CV monosyllable speech perception among age groups. CV monosyllable speech perception in the elderly (61.4 ± 25.5%) did not differ from that of young adults (65.9 ± 24.8%). Word recognition scores were significantly lower in the elderly (64.3 ± 28.1%) than young adults (80.4 ± 25.9%) (p < 0.05).

    DOI: 10.3109/00016489.2015.1062547

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  • [The age at which the grade of Special Child Dependent's Allowance Act can be judged in the case of deaf children].

    Yuko Kataoka, Kunihiro Fukushima, Akiko Sugaya, Yukihide Maeda, Kazunori Nishizaki

    Nihon Jibiinkoka Gakkai kaiho   117 ( 9 )   1200 - 4   2014年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    The spread of neonatal hearing screening has made the identification of hearing loss in early childhood possible, and most of the children with hearing loss are diagnosed and provided with early intervention within several months after their birth. However, they have to wait to receive the Special Child Dependent's Allowance until their hearing levels are evaluated with audiometers. Under the Special Child Dependent's Allowance Act now in force, a delay of several years occurs for those children before they can receive the allowance after diagnosis. We retrospectively reviewed hearing test results of children who had not reacted at 90dBnHL bilaterally in ABR within 12 months after birth, and examined when those results were certain enough to determine their allowance eligibility. We found that the eligibility in children with hearing loss alone could be determined at 1 year of age; as for children who had other disorders, since it was mostly difficult to test them with an audiometer, the diagnosis of hearing loss must always be made carefully but it was also possible to determine the eligibility for the allowance at 1 year of age.

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  • [Assessment of hearing aid outcome using CADL].

    Rie Nagayasu, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Kunihiro Fukushima, Kazunori Nishizaki

    Nihon Jibiinkoka Gakkai kaiho   117 ( 8 )   1126 - 31   2014年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    The presence of hearing impairment deteriorates patients' quality of life by affecting their daily-life communication. Several self-report assessments are available to evaluate the subjective outcome of hearing aids, however, the procedures to evaluate the impairment of communication induced by hearing impairment has not been well established. A PC-recorded audio file prepared to evaluate the communication ability of hearing aid users, by extracting fifteen spoken language items from the Communication ADL Test: sp-CADL. A before and after study was performed among the hearing aid users who were attending Okayama University Hospital to evaluate the improvement in each of the 15 sp-CADL scores. Twenty-one adults were included in this study whose age ranged from 22 to 83 years old (mean: 56.7 years old). The total and individual scores of the sp-CADL improved significantly after the use of the hearing aids (p < 0.05). The total sp-CADL score of the patients with hearing aids showed a good correlation with the best scores of the speech discrimination test measured before wearing hearing aids.

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  • 耳鼻科シリーズ 小児急性中耳炎診療ガイドライン

    片岡祐子, 西崎和則

    岡山医学会雑誌   126 ( 3 )   2014年

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  • ちょっと便利な診療ツール 外耳道パッキング素材

    片岡祐子

    JOHNS   30 ( 5 )   2014年

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  • Cochlin-tomoprotein (CTP) detection test identified perilymph leakage preoperatively in revision stapes surgery. 国際誌

    Yuko Kataoka, Tetsuo Ikezono, Kunihiro Fukushima, Koji Yuen, Yukihide Maeda, Akiko Sugaya, Kazunori Nishizaki

    Auris, nasus, larynx   40 ( 4 )   422 - 4   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Perilymphatic fistula (PLF) is defined as an abnormal leakage between perilymph from the labyrinth to the middle ear. Symptoms include hearing loss, tinnitus, and vertigo. The standard mode of PLF detection is intraoperative visualization of perilymph leakage and fistula, which ostensibly confirms the existence of PLF. Other possible methods of diagnosis include confirmation of pneumolabyrinth via diagnostic imaging. Recently, a cochlin-tomoprotein (CTP) detection test has been developed that allows definitive diagnosis of PLF-related hearing loss. We report the case of a 45-year-old man who presented with right-sided tinnitus, hearing loss, and dizziness 30 years after stapes surgery. Middle ear lavage was performed after myringotomy. A preoperative diagnosis of PLF was reached using the CTP detection test. Intraoperative observations included a necrotic long process of the incus, displaced wire piston, and fibrous tissue in the oval window. Perilymph leakage was not evident. The oval window was closed with fascia, and vertigo disappeared within 2 weeks postoperatively. When PLF is suspected after stapes surgery, the CTP detection test can be a useful, highly sensitive, and less invasive method for preoperative diagnosis.

    DOI: 10.1016/j.anl.2012.08.001

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  • Expression of toll-like receptors in chronic otitis media and cholesteatoma. 国際誌

    Haruka Hirai, Shin Kariya, Mitsuhiro Okano, Kunihiro Fukushima, Yuko Kataoka, Yukihide Maeda, Kazunori Nishizaki

    International journal of pediatric otorhinolaryngology   77 ( 5 )   674 - 6   2013年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Otitis media is one of the most common infectious diseases, especially in young children. Multiple factors affect the onset or development of otitis media. Human toll-like receptors recognize associated patterns and play a critical role in innate immune mechanisms. Toll-like receptors are considered to be important factors for clearance of infection and resolution of inflammation in otitis media. The purpose of this study was to evaluate the histological expression of toll-like receptor 2, which recognizes many kinds of pathogen-associated molecular patterns, and toll-like receptor 4, which recognizes lipopolysaccharide on Gram-negative bacteria, in tissue samples from patients with chronic otitis media and middle ear cholesteatoma. METHODS: Human middle ear tissue samples from 12 patients with chronic otitis media (n=7) and acquired middle ear cholesteatoma (n=5) were examined. Normal control middle ear samples without any inflammation were also included (n=7). The expressions of toll-like receptors 2 and 4 in middle ear tissues were examined immunohistochemically. RESULTS: Only one normal control middle ear sample showed weak expression of toll-like receptor 2, and toll-like receptor 4 was not observed in all control samples. On the other hand, both toll-like receptors 2 and 4 were markedly expressed in chronic otitis media and cholesteatoma. There was a significant difference between chronic otitis media and normal controls in the expressions of both toll-like receptors. Significant up-regulation of toll-like receptors 2 and 4 was observed in cholesteatoma as compared with control samples. CONCLUSIONS: Toll-like receptors 2 and 4 were strongly expressed in chronic otitis media and middle ear cholesteatoma. These findings suggest that toll-like receptors may play a principal role in human chronic otitis media and cholesteatoma.

    DOI: 10.1016/j.ijporl.2013.01.010

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  • [Subsidizing hearing aid purchase in mild to moderate pediatric hearing--pediatric status following prefectural assembly subvention].

    Yuko Kataoka, Kunihiro Fukushima, Akiko Sugaya, Yukihide Maeda, Yu Masuda, Kazunori Nishizaki

    Nihon Jibiinkoka Gakkai kaiho   114 ( 8 )   731 - 6   2011年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    The dissemination of newborn hearing screening (NHS) has enabled those with mild to moderate hearing loss to be diagnosed in early infancy. The "handicapped independence support law", however, prevents those not determined to be physically handicapped; i.e., those with mild to moderate hearing loss-, from government assistance in purchasing hearing aids. This results either in (i) parents purchasing hearing aids at their own expense or (ii) nonpurchase of hearing aids. To redress this situation, subvention in purchasing hearing aids of mild to moderate hearing loss children has been begun by some local governments. We petitioned for such aid at the Okayama Prefecture Assembly. A society for supporting pediatric hearing difficulty in Okayama Prefecture also submitted a similar petition in September 2009, and subvention began in April 2010 for all such children in Okayama Prefecture. We report procedures and details leading to this subvention.

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  • [Progressive or delayed early-onset pediatric sensorineural hearing loss].

    Yuko Kataoka, Kunihiro Fukushima, Yukihide Maeda, Akiko Sugaya, Rie Nagayasu, Yu Masuda, Kazunori Nishizaki

    Nihon Jibiinkoka Gakkai kaiho   114 ( 6 )   557 - 61   2011年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    The introduction of newborn-hearing screening has enabled early childhood hearing loss to be diagnosed and increased the number of children undergoing early care. Bilateral hearing loss is found in 0.08% of newborns and children whose hearing loss progresses or onset is delayed account for 4 to 30% of all pediatric hearing impairment. Children with perinatal risk factors tend to have deteriorated hearing or delayed-onset hearing loss in early childhood, necessitating audiometric follow-up. We also are aware of some children without risk factors who develop hearing impairment during infancy or early childhood. Hearing deterioration may be difficult to diagnose objectively, especially in young children, the presence of risk factors must be determines as soon as possible, especially given the lack of hearing management and close examination of children without apparent risk factors. We retrospectively studied children born from April 1998 to March 2007 and undergoing cochlear implantation as of April 2008. Among cases, we focused on 10 whose hearing impairment advanced during infancy -4 with risk factors known before hearing deterioration progressed, and 6 cases thought not to have any risk factors. We detected enlarged vestibular acquaduct in 3 of these 6 cases, and 3 more of whom had no risk factors -2 passing newborn-hearing screening and 1 in whom such screening detected hemilateral hearing loss. Our results underscore the need for early temporal computed tomography for detecting enlarged vestibular aquaduct. Even children with mild or hemilateral hearing loss should undergo audiometric and developmental testing at least every 6 months up to going to elementary school. Children suspected of impaired hearing should undergo thorough hearing tests regardless of newborn hearing-screening results to catch any problems early. Appropriate regular hearing and language development check-up tests must also be developed.

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  • 急性高度難聴に関する調査研究 難聴関連コネキシンの組織別発現パターン

    福島邦博, 前田幸英, 平井美紗都, 片岡祐子

    急性高度難聴に関する調査研究 平成21年度 総括・分担研究報告書   2010年

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  • IgA腎症の長期予後(10年予後)

    赤木博文, 土井彰, 福島邦博, 片岡祐子, 小坂道也, 小川晃弘, 西崎和則

    口腔・咽頭科   14 ( 1 )   2001年

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MISC

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講演・口頭発表等

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共同研究・競争的資金等の研究

  • 乳幼児中耳貯留液の診断における1000Hzティンパノメトリーの有用性の検討

    研究課題/領域番号:26462558  2014年04月 - 2017年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    片岡 祐子, 前田 幸英, 菅谷 明子

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    配分額:1820000円 ( 直接経費:1400000円 、 間接経費:420000円 )

    ティンパノメトリーによる鼓膜のインピーダンス測定は、中耳滲出液貯留を簡便に検出する検査法である。通常226Hzのプローブ音を用いるが、乳幼児には1000Hzが有用であるとされており、局所所見を取るのが困難な児にも推奨されている。当研究では乳幼児253耳に1000Hz、226Hzティンパノメトリーを実施し、臨床データと併せて有用性を検討した。1000Hzティンパノメトリーの感度84.6%、特異度62.3%であり、226Hzよりも感度は高いが、特異度は低い結果であった。乳幼児の滲出性中耳炎の診断には1000Hzティンパノメトリーだけでなく局所所見や検査データも考慮し、評価すべきである。

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  • 急性感音難聴の病態と治療のプロテオーム解析 -質量分析計を用いた解析-

    研究課題/領域番号:25462640  2013年04月 - 2016年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    前田 幸英, 福島 邦博, 假谷 伸, 片岡 祐子

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    配分額:3510000円 ( 直接経費:2700000円 、 間接経費:810000円 )

    急性感音難聴は比較的頻繁にみられ、難治性の病態である。急性感音難聴の治療にはステロイド投与が行われる。当研究ではマウスに対するステロイド投与で、蝸牛局所で発現が変動する蛋白質を質量分析計で解析し、急性感音難聴モデルにおいても蛋白発現を検討した。生体内の蝸牛から、質量分析計で247種類の蛋白質を同定し、ステロイド投与で発現量が変動する蛋白質を11同定した。音響外傷による難聴モデルマウスにおいて、前述の蛋白質のうち、Myelin protein zeroとHeat shock protein 70の発現がステロイド投与により変動することをウエスタンブロットで確認した。

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  • 学習障害関連遺伝子をターゲットとした人工内耳予後予測因子に関する研究

    研究課題/領域番号:25462641  2013年04月 - 2014年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    福島 邦博, 前田 幸英, 片岡 祐子, 菅谷 明子

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    配分額:4940000円 ( 直接経費:3800000円 、 間接経費:1140000円 )

    小児先天性難聴に対しては、現在人工内耳埋め込み術が早期(1歳前後)から適応されることが多くなっている。しかし、人工内耳装用児のすべてが順調な言語発達を示すとは限らず、その言語発達には個人差が大きい。特に低年齢の人工内耳装用児でその言語発達予後を予測することは容易ではなく、より適切な手法の開発が望まれている。遺伝子診断は、従来難聴の原因を探すために主として用いられてきたが、近年では学習障害などの原因遺伝子も明らかにされており、この技術を用いて人工内耳術後の言語発達予後予測を行うことをこの研究の目標とした。当面、その予備実験として難聴のない言語発達障害児童(特異的言語発達障害)において、既に海外で報告されている言語発達に影響を与える遺伝子での変異の有無を検討した。末梢血から採取したDNAを用い、パラレルシークエンス法によって候補遺伝子(FOXP2,DYA1C1,DCDC2, KIAA0319, ROBO1)の全エクソンにおける変異を検討した。意味のある変異を検出することはできなかった。日本語話者での遺伝子変異は人種的ないしは言語的な違いにより、欧米での遺伝子変異とパターンが異なる可能性があり、まず本邦患者を元にした新たな言語発達障害関連遺伝子の解析が望まれると考えられた。

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  • siRNA を用いた急性感音難聴治療モデル

    研究課題/領域番号:22591880  2010年 - 2012年

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    前田 幸英, 福島 邦博, 片岡 祐子

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    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

    現在開発中の急性感音難聴治療薬の標的分子である MAP kinase 群が、急性感音難聴発症時の蝸牛でどの様な時間経過で活性化しているか明らかにした。また siRNA 等による蛋白合成レベルでの治療介入モデルの構築にむけて、リン酸化 MAP kinase 群の量的変化と MAP kinase 蛋白総量の発現変化を個別に解析した。 マウス内耳において phospho-MEK1/ERK/P90RSK カスケードは、らせん神経節と感覚上皮で騒音暴露後 3-6 時間をピークに活性化していた。この際 total-MEK1/ERK/P90RSK には増加を認めず、 一時的なリン酸化によるもので蛋白合成を伴わないものと考えられた。JNK,p38MAPKについては 48 時間後のらせん神経節での遅発性活性化を認めた。p38MAPK の遅発性増加には蛋白合成を伴っていた。これらの所見は siRNA による蛋白合成抑制など、新たな急性感音難聴治療戦略の基盤となると考えられる。

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  • 軽度・中等度難聴児の補聴器装用効果ならびに補聴器購入費用助成事業の効果の検討

    研究課題/領域番号:22791604  2010年 - 2011年

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    片岡 祐子

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    配分額:2860000円 ( 直接経費:2200000円 、 間接経費:660000円 )

    平成22年度「岡山県軽度・中等度難聴児補聴器交付事業」を利用した30児(48台)であった。アンケート結果により、保護者たちは、事業の創設により補聴器装用を積極的に検討できるようになり、補聴効果も実感しているととらえていることが分かった。軽度・中等度難聴児47児に聴覚、言語発達検査を行い、統計学的解析を行った結果、軽度・中等度難聴児は健聴児と比較すると有意に語彙数が少ないこと、補聴器装用期間が長い群では語彙数が多いこと、また良聴耳の聴力が良好であるほど構文理解は良好であるという結果が得られた。

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  • 小児進行性・遅発性難聴の遺伝子解析

    研究課題/領域番号:20791194  2008年 - 2009年

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    片岡 祐子

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    小児期早期の進行性難聴、遅発性難聴を分類、また遺伝子解析、サイトメガロウイルス感染症の有無の検出、auditory neuropathy症例の遺伝子解析を行い、難聴児の聴力フォローアップのポイントについて検討した。進行性難聴例では前庭水管拡大症が多数みられ、遺伝子検査でもSLC26A4変異をみとめた児もあり、また先天性サイトメガロウイルス感染症と診断した児もあった。また、リスク因子を有しない児でも乳幼児期早期に難聴が進行した児もみられた。auditory neuropathy例ではOTOF遺伝子の変異はみとめなかった。当院でのインベーダー法による難聴遺伝子スクリーニングは平成21年12月に開始されたばかりであり、今後症例を増やして更に検討を進める必要がある。

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  • 蝸牛培養による聴覚関連遺伝子発現の網羅的検討-薬物治療モデルを中心に-

    研究課題/領域番号:19591969  2007年 - 2008年

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    福島 邦博, 前田 幸英, 片岡 祐子, 假谷 伸, 西崎 和則, 平井 美紗都

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    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

    感音難聴は現在までに有効な治療法が確立されていない。治療に有用な薬物を効率的に見いだすためには、内耳に作用しうる薬物をスクリーニングする手法の確立が必要である。今回我々は、内耳の器官培養を行い、難聴の治療として広く用いられているステロイドを作用させ、そこで発現する遺伝子の変化について検討した。ステロイド投与により、内耳において様々な遺伝子が発現することが示された。器官培養の系において内耳における薬理作用が検討することが可能であり、この実験系によって効果的な薬物治療戦略について検討可能であることが示された。

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担当授業科目

  • 先端医療疾病管理論 (2021年度) 前期  - その他