研究者詳細 - 園井　教裕

論文 - 園井　教裕

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Perioperative nutrition therapy for patients with head and neck or gastrointestinal cancer: a systematic review and meta-analysis

Masano Sagawa, Ryota Matsui, Akihiko Sano, Makoto Sakai, Shinichiro Hiraoka, Isao Tabei, Takayuki Imai, Hideo Matsumoto, Seiji Onogawa, Norihiro Sonoi, Shigeyuki Nagata, Ryo Ogawa, Shigeki Wakiyama, Yasuhiro Miyazaki, Koshi Kumagai, Rie Tsutsumi, Takehiro Okabayashi, Yu Uneno, Naoki Higashibeppu, Joji Kotani

Clinical Nutrition ESPEN 2025年4月

Preoperative Nutritional Status Influences Enteral Nutrition Weaning 6 Months Post-Surgery in Patients with Esophageal Cancer. 査読

Sonoi M., Shirakawa Y., Sonoi N., Noma K., Tanabe S., Maeda N., Morimatsu H.

Asian Pacific Journal of Cancer Prevention 26 ( 1 ) 263 - 267 2025年1月

Bonding Preformance of a New Self-adhesive Resin Cement with a Univeral Adhesive in Fiber Post Cementation for Traumatology 査読

Hiroaki TAKETA, Masao IRIE, Norihiro SONOI

日本外傷歯学会雑誌 20 ( 1 ) 13 - 20 2024年12月

未病対策で求められる多職種連携教育の充実化招待

園井教裕

日本未病学会雑誌 30 ( 2 ) 31 - 35 2024年8月

Dietary intervention for adult survivors of cancers other than breast cancer: A systematic review 査読

Hideo Matsumoto, Seiji Onogawa, Norihiro Sonoi, Masano Sagawa, Shigeki Wakiyama, Ryo Ogawa, Yasuhiro Miyazaki, Shigeyuki Nagata, Takehiro Okabayashi, Susumu Tazuma, Akihiko Futamura, Yu Uneno, Naoki Higashibeppu, Joji Kotani

Medicine 103 ( 26 ) e38675 - e38675 2024年6月

掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

Introduction:

Healthy eating and weight control are recommended for cancer survivors; however, dietary interventions are not routinely offered to them. This study aimed to assess the effects of dietary interventions on survival, nutritional status, morbidity, dietary changes, health-related quality of life (QOL), and clinical measures in cancer survivors.

Methods:

Searches were conducted from October 1, 2018 to November 21, 2011 in the Medline, EMBASE, CENTRAL, Emcare, and DARE electronic databases. We included randomized controlled trials (RCTs) that involved individuals diagnosed with cancer, excluding conference abstracts, case studies, other reviews, and meta-analyses, and screened the articles.

Results:

Eight studies were included in this meta-analysis. We observed significant improvements in QOL and clinical data in 3 of 6 studies and in one study, respectively, significant weight loss on anthropometry in 2 of 5 studies, and dietary improvement in 4 of 5 studies of adult cancer survivors. However, we did not observe any benefits of dietary intervention for cancer survivors with undernutrition.

Discussion:

Dietary interventions for adult cancer survivors might contribute to improving their nutritional status; however, further clarification requires a study that standardizes the intervention method. Furthermore, RCTs are required to determine the effects on cancer survivors with undernutrition.

DOI： 10.1097/md.0000000000038675

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多職種連携をめぐる現在の潮流〜歯科医療従事者はどうすれば多職種と未来を作ることができるのか〜招待査読

園井教裕

日本歯科先端技術研究所学術会誌 30 ( 2 ) 102 - 106 2024年6月

Impact of Perioperative Immunonutrition on Postoperative Outcomes for Patients Undergoing Head and Neck or Gastrointestinal Cancer Surgeries: A Systematic Review and Meta-analysis of Randomized Controlled Trials. 査読

Matsui R, Sagawa M, Sano A, Sakai M, Hiraoka SI, Tabei I, Imai T, Matsumoto H, Onogawa S, Sonoi N, Nagata S, Ogawa R, Wakiyama S, Miyazaki Y, Kumagai K, Tsutsumi R, Okabayashi T, Uneno Y, Higashibeppu N, Kotani J

Annals of Surgery 279 ( 3 ) 419 - 428 2024年3月

Adhisive Performance of a New Self-adhesive Resin Cement in Fiber Post Cementation for Traumatology 査読

Masao Irie, Norihiro Sonoi, Hiroaki Taketa

日本外傷歯学会雑誌 19 ( 1 ) 43 - 49 2023年12月

Body mass index and weight change are associated with mortality in chronic kidney disease: A retrospective cohort study using a Japanese medical claims database 査読

Ishida Y, Maeda K, Murotani K, Shimizu A, Ueshima J, Nagano A, Sonoi N, Inoue T, Mori N

Nutrition 2023年12月

Association of body mass index and weight change with death in patients with advanced cancer 査読

Yuria Ishida, Keisuke Maeda, Kenta Murotani, Akio Shimizu, Junko Ueshima, Ayano Nagano, Norihiro Sonoi, Tatsuro Inoue, Naoharu Mori

Nutirition 2023年11月

Personalized Preclinical Training in Dental Ergonomics and Endodontics in Undergraduate Dentistry Students (Pilot Study) 査読

Zulema Arias, Stephanie Haines, Tadashi Yamamoto, Kazu Hatanaka, Keisuke Yamashiro, Norihiro Sonoi, Shogo Takashiba

Acta Medica Okayama 77 ( 2 ) 147 - 159 2023年4月

学生を含む多職種で医療者教育ジャーナルクラブから新たな多職種連携教育の実践へ査読

三好智子, 猪田宏美, 園井教裕, 谷真規子

医学教育 54 ( 1 ) 96 - 97 2023年2月

Bonding ability of composite materials in three kinds of usage to tooth structure 査読

Masao IRIE, Norihiro Sonoi, Hiroaki TAKETA

西日本臨床小児口腔外科学会雑誌 14 ( 1 ) 1 - 12 2022年12月

Bonding Characteristics of a New Universal Self-adhesive Resin Cement for Traumatology 査読

Masao IRIE, Norihiro SONOI, Hiroaki TAKETA

日本外傷歯学会雑誌 18 ( 1 ) 37 - 44 2022年12月

Traumatonogy in Stomatology：Advantages of Universal Adhesive in Re-treatment of Fractured Resin Core 査読

Masao IRIE, Norihiro SONOI, Takahiro SEKINO

Journal of Japan Association of Dental Traumatology 17 ( 1 ) 2021年12月

全入院患者を対象とした口腔スクリーニングシステムの構築査読

園井教裕

日本外傷歯学会雑誌 16 ( 1 ) 7 - 12 2020年12月

Suggestion on dental traumatology: using of restorative materials 査読

Masao I, Sonoi N

Journal of West Japan Association of Clinical Pediatric Oral and Maxillofacial Surgery 2018年12月

IS1598 (IsPg4) distributed to abscess forming strains of Porphyromonas gingivalis may enhance virulence through upregulation of nrdD-like gene expression

Sonoi N, Maeda H, Murauchi T, Yamamoto T, Omori K, Kokeguchi S, Naruishi K, Takashiba S

New Microbiologica 41 ( 1 ) 52 - 60 2018年

担当区分：筆頭著者掲載種別：研究論文（学術雑誌）

©2018 by EDIMES-Edizioni Internazionali Srl. All rights reserved. An insertion sequence, IS1598 (IsPg4) has been found in virulent strains of Porphyromonas gingivalis in a murine abscess model. The present study was performed to investigate the effects of genetic rearrangements by IS1598 on the phenotypic characteristics of the virulent strains. For this purpose, we searched for a common insertion site of IS1598 among the virulent strains. Through cloning and database search, a common insertion site was identified beside an nrdD-like gene in the virulent FDC 381, W83 and W50 strains. In this region, predicted promoters of the nrdD-like gene and IS1598 are located in tandem, and accumulation of nrdD-like gene mRNA was 5-fold higher in virulent strains (W83, W50, FDC 381) than avirulent strains (ATCC33277, SU63, SUNY1021, ESO59 without IS1598). The role of the nrdD-like gene in virulence of P. gingivalis was investigated by constructing a nrdD-deficient mutant. In the murine abscess model, the parental W83 strain produced necrotic abscesses, while the nrdD-deficient mutant had almost lost this ability. Insertion of IS1598 into the nrdD-like gene promoter region may be related to the phenotypic differences in virulence among P. gingivalis strains through upregulation of the expression of this gene.

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Changes in attitudes of first-year dental school students toward end-of-life care after a lecture 査読

Norihiro Sonoi, Yoshihiko Soga, Jun-ichi Asaumi

Dental and Craniofacial Research（現：Global Dentistry） 1 ( 1 ) 2018年

オーラルマネジメント(それぞれの立場からの発言) 病院歯科の立場より看護師に期待される役割から連携を考える査読

永長周一郎, 品川隆, 園井教裕, 八重田淳, 角保徳

日本口腔感染症学会雑誌 22 ( 1 ) 26 - 28 2015年5月

A System Promoting Cooperation Between Medicine and Dentistry Using Key Performance Indicators and Importance-Performance Analysis

Shuichiro Nagaosa, Hironobu Matsushita, Jun Yaeda, Takashi Shinagawa, Norihiro Sonoi, Hiroyuki Nakamura, Hiromi Ohta, Masatoshi Usubuchi, Yasuhisa Arai, Yasunori Sumi

The 2nd International Conference of Serviceology 74 - 80 2014年

Histological and immunohistochemical features of gingival enlargement in a patient with AML

Norihiro Sonoi, Yoshihiko Soga, Hiroshi Maeda, Koichi Ichimura, Tadashi Yoshino, Kazutoshi Aoyama, Nobuharu Fujii, Yoshinobu Maeda, Mitsune Tanimoto, Richard Logan, Judith Raber-Durlacher, Shogo Takashiba

Odontology 100 ( 2 ) 254 - 257 2012年7月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed both before and after chemotherapy. The patient was a 39-year-old Japanese woman with AML-M4 showing gingival enlargement. Histological and immunohistochemical features of gingiva and bacterial counts in the periodontal pockets were examined before and after chemotherapy. The results were as follows: (1) infiltration of myelomonocytic blasts in enlarged gingiva; (2) resolution of gingival enlargement with complete remission of AML by anticancer chemotherapy; and (3) the numbers of bacteria in the periodontal pockets were not high and were not altered before or after chemotherapy. In patients with AML-M4, remarkable mucosal enlargement is not generally observed in the body except in the gingiva. We hypothesized that antigens derived from periodontal bacteria, even if they are not present in large numbers, could act as chemoattractants for myelomonocytic leukemic cells.

DOI： 10.1007/s10266-011-0051-0

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Influence of resin coating materials on Porphyromonas gingivalis attachment. 査読

Kumada A, Matsuka Y, Mine A, Ono M, Uehara J, Sonoi N, Ito T, Takashiba S, Kuboki T

Dental Materials Journal 31 ( 1 ) 86 - 91 2012年2月

Immune responses to Porphyromonas gingivalis infection suppress systemic inflammatory response in experimental murine model

Koji Naruishi, K. Omori, H. Maeda, N. Sonoi, K. Funakoshi, K. Hirai, M. Ishii, K. Kubo, H. Kobayashi, T. Tomiyama, D. Yamamoto, I. Tanimoto, K. Kunimatsu, S. Takashiba

Journal of Biological Regulators and Homeostatic Agents 25 ( 2 ) 195 - 202 2011年4月

掲載種別：研究論文（学術雑誌）

Periodontitis is localized infectious disease caused by periodontopathic bacteria such as Porphyromonas gingivalis (P. gingivalis), and the severity correlates to significance of immune responses. Recently, it has been reported that periodontitis is associated with the development of systemic disease such as diabetes and atherosclerosis because of increasing invasion of oral pathogens to the circulation. However, the association between local and systemic infectious responses is still unclear. In the present study, we examined the differences of biological responses in animals with or without bacterial infection. After Balb/c mice were infected subcutaneously with live P. gingivalis W83, serum, skin and liver were collected according to experimental protocol. The skin and liver tissues were observed pathologically by haematoxylin-eosin staining, and serum IL-6 levels were measured using ELISA method. Throughout the experimental period, conditions of the mice were observed continuously. As expected, severe infiltration of leukocytes were observed at inflamed skin corresponding to the number of bacterial challenges. Although no inflammatory appearance of skin was observed, serum IL-6 levels were increased dramatically (P < 0.01, Student's t-test) and liver tissues were injured in the mice without bacterial challenge. Interestingly, although severe inflammatory appearance of the skin was observed, serum IL-6 levels were not increased and no inflammatory responses were observed in the liver of the 3-times bacterially challenged group. Importantly, immunoglobulin G against P. gingivalis W83 was detected in the blood of mice with 3-times bacterial challenge corresponding to improvement of weight loss and survival. In conclusion, although multiple infections develop severe localized inflammation, the immune system should be sufficient to protect the systemic inflammatory responses. Copyright © by BIOLIFE, s.a.s.

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Distribution of Archaea in Japanese patients with periodontitis and humoral immune response to the components. 国際誌

Kokoro Yamabe, Hiroshi Maeda, Susumu Kokeguchi, Ichiro Tanimoto, Norihiro Sonoi, Susumu Asakawa, Shogo Takashiba

FEMS microbiology letters 287 ( 1 ) 69 - 75 2008年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

There is controversy regarding the existence of archaeal pathogens. Periodontitis is one of the human diseases in which Archaea have been suggested to have roles as pathogens. This study was performed to investigate the distribution of Archaea in Japanese patients with periodontitis and to examine the serum IgG responses to archaeal components. Subgingival plaque samples were collected from 111 periodontal pockets of 49 patients (17 with aggressive periodontitis and 32 with chronic periodontitis), and 30 subgingival plaque samples were collected from 17 healthy subjects. By PCR targeting the 16S rRNA gene, Archaea were detected in 15 plaque samples (13.5% of total samples) from 11 patients (29.4% of patients with aggressive periodontitis and 18.8% of patients with chronic periodontitis). Archaea were detected mostly (14/15) in severe diseased sites (pocket depth > or =6 mm), while no amplicons were observed in any samples from healthy controls. Sequence analysis of the PCR products revealed that the majority of Archaea in periodontal pockets were a Methanobrevibacter oralis-like phylotype. Western immunoblotting detected IgG antibodies against M. oralis in eight of the 11 sera from patients. These results suggest the potential of Archaea (M. oralis) as an antigenic pathogen of periodontitis.

DOI： 10.1111/j.1574-6968.2008.01304.x

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Porphyromonas gingivalisの膿瘍形成能へ与えるnrdD様遺伝子の病原性査読

園井教裕

岡山歯学会雑誌 27 ( 1 ) 2008年

造血器腫瘍を中心とした血液疾患患者における歯周病の重症度とPorphyromonas gingivalisに対する血清IgG抗体価との関連性に関する研究

曽我賢彦, 岩本義博, 谷本一郎, 浅田薫, 横井彩, 目黒道生, 工藤値英子, 吉澤さゆり, 山部こころ, 外山裕, 園井教裕, 岩田宏隆, 岡田祐佳, 冨山高史, 新井英雄, 西村英紀, 高柴正悟

日本歯科保存学雑誌 49 ( 6 ) 731 - 738 2006年12月

記述言語：日本語出版者・発行元：(NPO)日本歯科保存学会

血液疾患患者122名を対象に、歯周病原性細菌として代表的なP.gingivalisに対する血清IgG抗体価と歯周病の程度との間に関連がみられるか検討した。結果、多様な血液像(白血球減少など)を呈する血液疾患患者においても健常者と同様に歯周病の程度が重いほどIgG抗体価は高値であった。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2006&ichushi_jid=J01092&link_issn=&doc_id=20070117080006&doc_link_id=%2Fdo1conde%2F2006%2F004906%2F006%2F0731-0738%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdo1conde%2F2006%2F004906%2F006%2F0731-0738%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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