研究者詳細 - 園井　教裕

論文 - 園井　教裕

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A System Promoting Cooperation Between Medicine and Dentistry Using Key Performance Indicators and Importance-Performance Analysis

Shuichiro Nagaosa, Hironobu Matsushita, Jun Yaeda, Takashi Shinagawa, Norihiro Sonoi, Hiroyuki Nakamura, Hiromi Ohta, Masatoshi Usubuchi, Yasuhisa Arai, Yasunori Sumi

The 2nd International Conference of Serviceology 74 - 80 2014年

Histological and immunohistochemical features of gingival enlargement in a patient with AML

Norihiro Sonoi, Yoshihiko Soga, Hiroshi Maeda, Koichi Ichimura, Tadashi Yoshino, Kazutoshi Aoyama, Nobuharu Fujii, Yoshinobu Maeda, Mitsune Tanimoto, Richard Logan, Judith Raber-Durlacher, Shogo Takashiba

Odontology 100 ( 2 ) 254 - 257 2012年7月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed both before and after chemotherapy. The patient was a 39-year-old Japanese woman with AML-M4 showing gingival enlargement. Histological and immunohistochemical features of gingiva and bacterial counts in the periodontal pockets were examined before and after chemotherapy. The results were as follows: (1) infiltration of myelomonocytic blasts in enlarged gingiva; (2) resolution of gingival enlargement with complete remission of AML by anticancer chemotherapy; and (3) the numbers of bacteria in the periodontal pockets were not high and were not altered before or after chemotherapy. In patients with AML-M4, remarkable mucosal enlargement is not generally observed in the body except in the gingiva. We hypothesized that antigens derived from periodontal bacteria, even if they are not present in large numbers, could act as chemoattractants for myelomonocytic leukemic cells.

DOI： 10.1007/s10266-011-0051-0

PubMed

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Influence of resin coating materials on Porphyromonas gingivalis attachment. 査読

Kumada A, Matsuka Y, Mine A, Ono M, Uehara J, Sonoi N, Ito T, Takashiba S, Kuboki T

Dental Materials Journal 31 ( 1 ) 86 - 91 2012年2月

Immune responses to Porphyromonas gingivalis infection suppress systemic inflammatory response in experimental murine model

Koji Naruishi, K. Omori, H. Maeda, N. Sonoi, K. Funakoshi, K. Hirai, M. Ishii, K. Kubo, H. Kobayashi, T. Tomiyama, D. Yamamoto, I. Tanimoto, K. Kunimatsu, S. Takashiba

Journal of Biological Regulators and Homeostatic Agents 25 ( 2 ) 195 - 202 2011年4月

掲載種別：研究論文（学術雑誌）

Periodontitis is localized infectious disease caused by periodontopathic bacteria such as Porphyromonas gingivalis (P. gingivalis), and the severity correlates to significance of immune responses. Recently, it has been reported that periodontitis is associated with the development of systemic disease such as diabetes and atherosclerosis because of increasing invasion of oral pathogens to the circulation. However, the association between local and systemic infectious responses is still unclear. In the present study, we examined the differences of biological responses in animals with or without bacterial infection. After Balb/c mice were infected subcutaneously with live P. gingivalis W83, serum, skin and liver were collected according to experimental protocol. The skin and liver tissues were observed pathologically by haematoxylin-eosin staining, and serum IL-6 levels were measured using ELISA method. Throughout the experimental period, conditions of the mice were observed continuously. As expected, severe infiltration of leukocytes were observed at inflamed skin corresponding to the number of bacterial challenges. Although no inflammatory appearance of skin was observed, serum IL-6 levels were increased dramatically (P < 0.01, Student's t-test) and liver tissues were injured in the mice without bacterial challenge. Interestingly, although severe inflammatory appearance of the skin was observed, serum IL-6 levels were not increased and no inflammatory responses were observed in the liver of the 3-times bacterially challenged group. Importantly, immunoglobulin G against P. gingivalis W83 was detected in the blood of mice with 3-times bacterial challenge corresponding to improvement of weight loss and survival. In conclusion, although multiple infections develop severe localized inflammation, the immune system should be sufficient to protect the systemic inflammatory responses. Copyright © by BIOLIFE, s.a.s.

Scopus

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Distribution of Archaea in Japanese patients with periodontitis and humoral immune response to the components. 国際誌

Kokoro Yamabe, Hiroshi Maeda, Susumu Kokeguchi, Ichiro Tanimoto, Norihiro Sonoi, Susumu Asakawa, Shogo Takashiba

FEMS microbiology letters 287 ( 1 ) 69 - 75 2008年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

There is controversy regarding the existence of archaeal pathogens. Periodontitis is one of the human diseases in which Archaea have been suggested to have roles as pathogens. This study was performed to investigate the distribution of Archaea in Japanese patients with periodontitis and to examine the serum IgG responses to archaeal components. Subgingival plaque samples were collected from 111 periodontal pockets of 49 patients (17 with aggressive periodontitis and 32 with chronic periodontitis), and 30 subgingival plaque samples were collected from 17 healthy subjects. By PCR targeting the 16S rRNA gene, Archaea were detected in 15 plaque samples (13.5% of total samples) from 11 patients (29.4% of patients with aggressive periodontitis and 18.8% of patients with chronic periodontitis). Archaea were detected mostly (14/15) in severe diseased sites (pocket depth > or =6 mm), while no amplicons were observed in any samples from healthy controls. Sequence analysis of the PCR products revealed that the majority of Archaea in periodontal pockets were a Methanobrevibacter oralis-like phylotype. Western immunoblotting detected IgG antibodies against M. oralis in eight of the 11 sera from patients. These results suggest the potential of Archaea (M. oralis) as an antigenic pathogen of periodontitis.

DOI： 10.1111/j.1574-6968.2008.01304.x

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Porphyromonas gingivalisの膿瘍形成能へ与えるnrdD様遺伝子の病原性査読

園井教裕

岡山歯学会雑誌 27 ( 1 ) 2008年

造血器腫瘍を中心とした血液疾患患者における歯周病の重症度とPorphyromonas gingivalisに対する血清IgG抗体価との関連性に関する研究

曽我賢彦, 岩本義博, 谷本一郎, 浅田薫, 横井彩, 目黒道生, 工藤値英子, 吉澤さゆり, 山部こころ, 外山裕, 園井教裕, 岩田宏隆, 岡田祐佳, 冨山高史, 新井英雄, 西村英紀, 高柴正悟

日本歯科保存学雑誌 49 ( 6 ) 731 - 738 2006年12月

記述言語：日本語出版者・発行元：(NPO)日本歯科保存学会

血液疾患患者122名を対象に、歯周病原性細菌として代表的なP.gingivalisに対する血清IgG抗体価と歯周病の程度との間に関連がみられるか検討した。結果、多様な血液像(白血球減少など)を呈する血液疾患患者においても健常者と同様に歯周病の程度が重いほどIgG抗体価は高値であった。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2006&ichushi_jid=J01092&link_issn=&doc_id=20070117080006&doc_link_id=%2Fdo1conde%2F2006%2F004906%2F006%2F0731-0738%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdo1conde%2F2006%2F004906%2F006%2F0731-0738%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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