Faculty Profiles - MIYAZAKI Ikuko

MISC - MIYAZAKI Ikuko

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Quinone formation in acute methamphetamine-induced neurotoxicity

MIYAZAKI Ikuko, ASANUMA Masato, DIAZ-CORRALES Francisco J, MIYOSHI Ko, SHIMIZU Masako, KITAICHI Kiyoyuki, OGAWA Norio

25 ( 6 ) 342 - 342 2005.12

Dopaminergic cell-specific involvement of parkin in manganese-induced neuronal death

MIYAZAKI Ikuko, ASANUMA Masato, HIGASHI Youichirou, HATTORI Nobutaka, MIZUNO Yoshikuni, OGAWA Norio

23 ( 6 ) 322 - 322 2003.12

Rotenone induces fragmentation of Golgi apparatus in dopaminergic neuroblastoma cell line

DIAZ Francisco, ASANUMA Masato, MIYAZAKI Ikuko, OGAWA Norio

23 ( 6 ) 311 - 311 2003.12

New aspects of neuroprotective effects of nonsteroidal anti-inflammatory drugs

Masato Asanuma, Ikuko Miyazaki, Takeshi Tsuji, Norio Ogawa

Japanese Journal of Neuropsychopharmacology 23 ( 3 ) 111 - 119 2003.6

Language：Japanese Publishing type：Book review, literature introduction, etc.

Nonsteroidal anti-inflammatory drugs (NSAIDs) exert anti -inflammatory, analgesic and antipyretic activities and are involved in the suppression of prostaglandin synthesis by inhibiting cyclooxygenase (COX), a prostaglandin synthesizing enzyme. It has been recently revealed that NSAIDs also possess inhibitory effects on the generating system of nitric oxide radicals and modulating effects on transcription factors and nuclear receptors which are related to inflammatory reactions. Since it has been reported that inflammatory processes are associated with the pathophysiology of several neurodegenerative diseases and that NSAIDs inhibit amyloid β-protein-induced neurotoxicity to reduce the risk for Alzheimer's disease, a number of studies have been conducted focusing on the neuroprotective effects of NSAIDs. It has been clarified that the drugs exert neuroprotective effects, which are not related to their COX-inhibiting property, on pathophysiology of various neurological disorders. In this article, new aspects of neuroprotective effects of NSAIDs have been reviewed, especially, in Alzheimer's disease and Parkinson's disease, discussing various pharmacological effects of NSAIDs other than their inhibitory action on COX.

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Complemental effects of tyrosinase, melanin synthetic enzyme, on dopamine containing neurons

ASANUMA Masato, MIYAZAKI Ikuko, HIGASHI Youichirou, TANAKA Ken-ichi, OGAWA Norio

22 ( 6 ) 360 - 360 2002.12