2021/12/26 更新

写真a

マスイ マサノリ
増井 正典
MASUI MASANORI
所属
医歯薬学域 助教
職名
助教
プロフィール

歯科医師

(公社)日本口腔外科学会認定「口腔外科認定医」

外部リンク

学位

  • 博士 (歯学) ( 2017年3月   岡山大学 )

研究キーワード

  • 口腔外科学

  • 顎変形症

  • 口腔癌

  • ミッドカイン

研究分野

  • ライフサイエンス / 病態系口腔科学

  • ライフサイエンス / 外科系歯学

学歴

  • 岡山大学大学院   医歯薬学総合研究科 病態制御科学専攻 口腔顎顔面外科学  

    2013年4月 - 2017年3月

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  • 岡山大学   Dental School   School of Dentistry

    2006年4月 - 2012年3月

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  • 兵庫県立龍野高等学校    

    2003年4月 - 2006年3月

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経歴

  • 岡山大学   学術研究院 医歯薬学域 口腔顎顔面外科学分野   助教

    2021年9月 - 現在

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  • 岡山大学病院   口腔外科・口腔顎顔面外科部門   医員

    2021年4月 - 2021年8月

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  • 岡山大学病院   高度救命救急センター   医員

    2020年10月 - 2021年3月

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  • 岡山大学病院   口腔外科(病態系)   医員

    2020年4月 - 2020年9月

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  • 香川県立中央病院   歯科口腔外科

    2017年4月 - 2020年3月

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  • 岡山大学病院   卒後臨床研修センター歯科研修部門   歯科研修医

    2012年4月 - 2013年3月

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▼全件表示

所属学協会

  • 日本頭頸部癌学会

    2021年3月 - 現在

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  • 日本顎顔面インプラント学会

    2018年10月 - 現在

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  • 日本口腔顎顎顔面外傷学会

    2018年6月 - 現在

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  • 日本顎変形症学会

    2018年3月 - 現在

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  • 日本口腔科学会

    2017年4月 - 現在

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  • 岡山歯学会

    2016年9月 - 現在

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  • 日本口腔腫瘍学会

    2014年7月 - 現在

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  • 日本口腔外科学会

    2012年7月 - 現在

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論文

  • A rare anatomical variation of the submental artery. 査読 国際誌

    Masanori Masui, Soichiro Ibaragi, Tatsuo Okui, R Shane Tubbs, Joe Iwanaga

    Surgical and radiologic anatomy : SRA   43 ( 11 )   1805 - 1808   2021年11月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The submental artery usually runs anteriorly on the inferior surface of the mylohyoid muscle, giving branches to that muscle and to the anterior belly of the digastric muscle, finally supplying the submental skin. Branches of it often perforate the mylohyoid muscle and enter the sublingual space. During a routine anatomy dissection, we encountered a case in which the main trunk of the submental artery perforated the mylohyoid muscle, where the sublingual artery usually runs. No branches coursed anteriorly to supply the submental skin. To our knowledge, this submental artery variation has not been reported in the English literature. Any surgical procedure in the submandibular area, such as the axial pattern submental local flap, requires knowledge of such arterial variations.

    DOI: 10.1007/s00276-021-02830-6

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  • Displacement of lower third molar into floor of mouth: a single institutional experience. 国際誌

    Masanori Masui, Soichiro Ibaragi, Yohei Takeshita, Joe Iwanaga, Yuki Kunisada, Akira Sasaki

    Oral and maxillofacial surgery   2021年10月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The displacement of the tooth/tooth fragment into the floor of mouth sometimes happens during the lower third molar surgery and the patients are usually referred to oral and maxillofacial surgeons. To date, however, there is no consensus how to manage the displaced tooth due to the lack of available data. METHODS: In this study, we have retrospectively analyzed the management of the displaced lower third molar into the floor of mouth. Our institute experienced seven cases during 2010 to 2020. RESULTS: Incidence rate of the lingual nerve injury caused by displacement of the lower third molar was 1/7. Six patients out of seven underwent surgical removal of the displaced fragment. The direct approach was used when the fragment was palpable superficially and the fragment was horizontally located away from the lingual plate (2 cases), while when the fragment was not palpable, or was palpable and adjacent to the lingual plate, the lingual mucoperiosteal flap was selected (4 cases). CONCLUSION: We conclude that the palpation and preoperative diagnosis with computed tomographic images are significantly important to decide a better and most effective surgical approach.

    DOI: 10.1007/s10006-021-01012-3

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  • Examination of Diseases Requiring Oral Surgery Treated via Medical- Dental Cooperation in the Department of Oral and Maxillofacial Surgery (Biopathology), Okayama University Hospital

    Masanori Masui, Tsuyoshi Shimo, Norie Yoshioka, Soichiro Ibaragi, Tatsuo Okui, Yuki Kunisada, Mayumi Yao, Shoko Yoshida, Yurika Murase, Koji Kishimoto, Akiyoshi Nishiyama, Yoshihiko Soga, Akira Sasaki

    International Journal of Surgery & Surgical Procedures   2 ( 1 )   2017年3月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Graphyonline Publications PVT, Ltd.  

    DOI: 10.15344/2456-4443/2017/115

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  • Novel Midkine Inhibitor iMDK Inhibits Tumor Growth and Angiogenesis in Oral Squamous Cell Carcinoma. 国際誌

    Masanori Masui, Tatsuo Okui, Tsuyoshi Shimo, Kiyofumi Takabatake, Takuya Fukazawa, Kenichi Matsumoto, Naito Kurio, Soichiro Ibaragi, Yoshio Naomoto, Hitoshi Nagatsuka, Akira Sasaki

    Anticancer research   36 ( 6 )   2775 - 81   2016年6月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Midkine is a heparin-binding growth factor highly expressed in various human malignant tumors. However, its role in the growth of oral squamous cell carcinoma is not well understood. In this study, we analyzed the antitumor effect of a novel midkine inhibitor (iMDK) against oral squamous cell carcinoma. Administration of iMDK induced a robust antitumor response and suppressed cluster of differentiation 31 (CD31) expression in oral squamous cell carcinoma HSC-2 cells and SAS cells xenograft models. iMDK inhibited the proliferation of these cells dose-dependently, as well as the expression of midkine and phospho-extracellular signal-regulated kinase in HSC-2 and SAS cells. Moreover, iMDK significantly inhibited vascular endothelial growth factor and induced tube growth of human umbilical vein endothelial cells in a dose-dependent fashion. These findings suggest that midkine is critically involved in oral squamous cell carcinoma and iMDK can be effectively used for the treatment of oral squamous cell carcinoma.

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  • A case of langerhans cell histiocytosis of the mandible that spontaneously regressed after biopsy in a child. 国際誌

    Kisho Ono, Tatsuo Okui, Yuki Kunisada, Kyoichi Obata, Masanori Masui, Shoji Ryumon, Soichiro Ibaragi, Tomoya Nakamura, Akira Sasaki

    Clinical case reports   9 ( 6 )   e04321   2021年6月

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    記述言語:英語  

    In younger patients of LCH, we should consider that the effectiveness of follow-up without aggressive treatment for SS-type LCH in the oral and maxillofacial bone. However, there are very rare case in which an SS-type LCH recurred after showing a healing tendency. Regular follow-up must be performed even after healing.

    DOI: 10.1002/ccr3.4321

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  • Comprehensive review of lower third molar management: A guide for improved informed consent. 国際誌

    Joe Iwanaga, Yuki Kunisada, Masanori Masui, Kyoichi Obata, Yohei Takeshita, Kotaro Sato, Shogo Kikuta, Yushi Abe, Yuki Matsushita, Jingo Kusukawa, R Shane Tubbs, Soichiro Ibaragi

    Clinical anatomy (New York, N.Y.)   34 ( 2 )   224 - 243   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Lower third molar removal is the most commonly performed dental surgical procedure. Nevertheless, it is difficult to ensure that all the informed consent forms given to patients are based on the best evidence as many newer publications could change the conclusions of previous research. Therefore, the goal of this review article is to cover existing meta-analyses, randomized control trials, and related articles in order to collect data for improved and more current informed consent.

    DOI: 10.1002/ca.23693

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  • A case of oral cancer with delayed occipital lymph node metastasis: Case report. 国際誌

    Kisho Ono, Norie Yoshioka, Masanori Masui, Kyoichi Obata, Yuki Kunisada, Tatsuo Okui, Soichiro Ibaragi, Hotaka Kawai, Hitoshi Nagatsuka, Akira Sasaki

    Clinical case reports   8 ( 12 )   2469 - 2475   2020年12月

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    記述言語:英語  

    Consideration of unexpected metastasis in patients who have undergone neck dissection with advanced tumors must be anticipated with careful follow-up.

    DOI: 10.1002/ccr3.3086

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  • High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer. 国際誌

    Tomoya Nakamura, Tatsuo Okui, Kazuaki Hasegawa, Shoji Ryumon, Soichiro Ibaragi, Kisho Ono, Yuki Kunisada, Kyoichi Obata, Masanori Masui, Tsuyoshi Shimo, Akira Sasaki

    Oncology reports   44 ( 6 )   2547 - 2558   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Advanced head and neck cancer (HNC) can invade facial bone and cause bone pain, thus posing a significant challenge to the quality of life of patients presenting with advanced HNC. The present study was designed to investigate HNC bone pain (HNC‑BP) in an intratibial mouse xenograft model that utilized an HNC cell line (SAS cells). These mice develop HNC‑BP that is associated with an expression of phosphorylated ERK1/2 (pERK1/2), which is a molecular indicator of neuron excitation in dorsal root ganglia (DRG) sensory neurons. Our experiments demonstrated that the inhibition of high mobility group box 1 (HMGB1) by short hairpin (shRNA) transduction, HMGB1 neutralizing antibody, and HMGB1 receptor antagonist suppressed the HNC‑BP and the pERK1/2 expression in DRG. It was also observed that HNC‑derived HMGB1 increased the expression of the acid‑sensing nociceptor, transient receptor potential vanilloid 1 (TRPV1), which is a major cause of osteoclastic HNC‑BP in DRG. Collectively, our results demonstrated that HMGB1 originating in HNC evokes HNC‑BP via direct HMGB1 signaling and hypersensitization for the acid environment in sensory neurons.

    DOI: 10.3892/or.2020.7788

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  • High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4. 国際誌

    Yumi Sakamoto, Tatsuo Okui, Toshiyuki Yoneda, Shoji Ryumon, Tomoya Nakamura, Hotaka Kawai, Yuki Kunisada, Soichiro Ibaragi, Masanori Masui, Kisho Ono, Kyoichi Obata, Tsuyoshi Shimo, Akira Sasaki

    Biochemical and biophysical research communications   531 ( 3 )   422 - 430   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Bone destruction of maxillary and mandibular bone by invasive oral squamous cell cancer (OSCC) raises various problems in the management of patients, resulting in poor outcomes and survival. However, the mechanism behind bone destruction by OSCC remains unclear. High-mobility group box 1 (HMGB1), a highly conserved ubiquitous nuclear non-histone DNA-binding protein, has been demonstrated to be secreted by aggressive cancers and regulate osteoclastogenesis, a central player during bone destruction. We therefore reasoned that HMGB1 secreted by OSCCs contributes to bone destruction. Our results showed that HMGB1 is produced by human cell lines of OSCC and promotes osteoclastogenesis via up-regulation of the expression of receptor activator of nuclear factor kappa-Β ligand in osteoblasts and osteocytes, and consequently osteoclastic bone destruction in mice. Further, we found that these actions of HMGB1 are mediated via the receptor for advanced glycation end products and toll-like receptors. These findings suggest that HMGB1 of OSCC and its down-stream signal pathways are potential targets for the treatment of bone destruction associated with advanced OSCC.

    DOI: 10.1016/j.bbrc.2020.07.120

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  • Maxillofacial Trauma Surgery Patients With Titanium Osteosynthesis Miniplates: Remove or Not?

    Shintaro Sukegawa, Masanori Masui, Yuka Sukegawa-Takahashi, Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Hitoshi Nagatsuka, Yoshihiko Furuki

    JOURNAL OF CRANIOFACIAL SURGERY   31 ( 5 )   1338 - 1342   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    The authors examined the timing and causes of titanium miniplate removal after maxillofacial trauma surgery. The authors performed a retrospective study of maxillofacial fracture patients in whom maxillofacial osteosynthesis miniplates were inserted or removed at the Kagawa Prefectural Central Hospital, between 2008 and 2017. Predictive variables were age, sex, fracture site distribution, and time to miniplate removal with or without complications in relation to primary outcome variables. Among 185 patients, 440 miniplates were inserted and 272 miniplates were removed. In total, 116 patients (73.4%) had 282 miniplates (64.1%) removed, of which 4.8% fracture sites and 5.7% miniplates were removed because of complications. The mean time to miniplate removal was 630.9 and 258.0 days in patients with and without complications, respectively. There was a statistically significant difference in miniplate removal and miniplate retention relative to age and sex. This difference was not related to the presence or absence of sex- or age-related complications. The miniplates as osteosynthesis material were safe and useful for a long period of time with relatively few complications. Because complications requiring miniplate removal occurred within 1 or after 5 years postoperatively, osteosynthesis miniplate treatments should be decided while considering the patient's age and sex. Long-term follow-up is recommended for miniplates that remain implanted for >1 year.

    DOI: 10.1097/SCS.0000000000006352

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  • Evaluation of Open Reduction and Internal Fixation of Mandibular Condyle Fracture by Intraoperative Cone-Beam Computed Tomography in a Hybrid Operating Room

    Shintaro Sukegawa, Masanori Masui, Takahiro Kanno, Masayuki Miki, Hitoshi Nakamoto, Yoshihiko Furuki

    JOURNAL OF CRANIOFACIAL SURGERY   31 ( 3 )   762 - 765   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Condylar fractures are the most common fractures of the mandible, and treatment of mandibular condylar fractures by maxillofacial surgeons is a very important procedure. However, the surgical approaches have anatomical limitations. Therefore, it is difficult to evaluate the reduction achieved in open reduction and internal fixation because of the uncertainty in securing a sufficient operative field. As a potential solution, the authors evaluated the benefits of intraoperative cone-beam computed tomography (CBCT) with high image quality performed in a hybrid operating room. Intraoperative CBCT is easy to perform in a hybrid operating room, and it is possible to quickly evaluate high-quality CT images, including 3D images. Because the state of reduction of mandibular condylar fractures also affects the prognosis of treatment, more precise reduction and fixation should improve prognoses. The use of CBCT in a hybrid operating room also avoids re-operation, and patients benefit from minimum invasive surgery. Intraoperative CBCT is a very useful strategy for evaluation of mandibular condylar fracture surgical treatment.

    DOI: 10.1097/SCS.0000000000006101

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  • 地域歯科医師会の口腔がん検診により早期治療をなし得た若年成人舌癌の1例

    助川 信太郎, 増井 正典, 助川 由佳, 岸本 司, 佐藤 愛, 雑賀 将斗, 古木 良彦

    香川県立中央病院医学雑誌   39   20 - 25   2020年3月

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    記述言語:日本語   出版者・発行元:香川県立中央病院  

    口腔癌における20歳代の若年者成人の割合は非常に少なく、早期発見による口腔癌治療の役割は大きい。今回、香川県歯科医師会主催の口腔がん検診で発見された若年成人早期舌癌を経験したのでその概要を報告する。症例は27歳女性。平成X年8月頃より、左側舌の白斑を認知するも自覚症状を認めなかった。平成X+1年1月に口腔がん検診を受診し、口腔癌の可能性を指摘され、精査加療依頼に当科を紹介受診した。左側舌縁部に25×15mm大の外向性白色粘膜病変を認め、中心やや後方部は、10×10mm大で中心部に硬結を伴うびらん性病変であった。悪性腫瘍を疑い生検を施行し、舌扁平上皮癌(cT1N0M0、Stage I)の診断を得た。根治的治療を目的に左側舌部切除術を行った。現在術後1年を経過し、腫瘍の再発や所属リンパ節への転移、遠隔転移は認められない。口腔がん検診による啓蒙、社会貢献度は高く、癌の早期発見、早期治療に導き得る可能性は高いと考えられた。(著者抄録)

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  • A retrospective comparative study of mandibular fracture treatment with internal fixation using reconstruction plate versus miniplates. 国際誌

    Shintaro Sukegawa, Takahiro Kanno, Masanori Masui, Yuka Sukegawa-Takahashi, Tsukasa Kishimoto, Ai Sato, Yoshihiko Furuki

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery   47 ( 8 )   1175 - 1180   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: This study compared the clinical success rates of mandibular fracture treatment using reconstruction plates or miniplates and clarified the selection criteria for reconstruction plates. METHODS: All patients who had surgically-treated mandible fractures from 2008 to 2017 with sufficient follow-up were retrospectively analyzed for information about the fracture condition, treatment, and outcomes. RESULTS: A total of 126 surgically-treated mandible fractures without mandibular condylar fracture in 105 patients (76 male, 29 female) were included. Reconstruction plates were used in 32 fractures with very good postoperative occlusal function. Four cases with complications requiring reoperation were treated using only miniplates. Variables that were statistically associated with follow-up surgery included simple versus comminuted mandible fracture, and the absence of teeth that could be used for intermaxillary fixation (P < 0.05). In the miniplates treatment for comminuted fracture, there was a significant difference in the treatment outcome depending on the number of free bone-fragments and the presence of bone-fragments requiring removal within 1 cm (P < 0.05). CONCLUSION: Reconstruction plates provided better treatment outcomes for comminuted fractures and fractures without teeth. Selecting a reconstruction plate that is capable of sufficiently overloading is important in comminuted fractures with multiple free bone-fragments and bone-fragments requiring removal.

    DOI: 10.1016/j.jcms.2018.09.025

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  • Which fixation methods are better between three-dimensional anatomical plate and two miniplates for the mandibular subcondylar fracture open treatment? 国際誌

    Shintaro Sukegawa, Takahiro Kanno, Masanori Masui, Yuka Sukegawa-Takahashi, Tsukasa Kishimoto, Ai Sato, Yoshihiko Furuki

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery   47 ( 5 )   771 - 777   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To compare the clinical outcomes of a single three-dimensional (3-D) anatomical plate versus two conventional straight miniplates for the open treatment of mandibular subcondylar fractures. METHODS: This retrospective clinical study included patients with mandibular subcondylar fractures treated by the retromandibular transparotid approach using a 3-D plate or two straight miniplates. Outcome variables included preoperative conditions of patients and fractures, extent of postoperative bone healing, and incidence of complications. Other variables included age, sex, fracture site, and follow-up duration. Variables were evaluated using descriptive statistics and compared between groups. RESULTS: Twenty-eight fractures were analyzed: 13 fractures using 3-D plate and 15 fractures using two straight miniplates. None of the assessed variables showed significant differences between the two groups (p < 0.05). Unfortunately, in the 3-D plate group, reoperation was necessary for nonunion owing to plate breakage in one case with a bone defect around the fracture. CONCLUSION: The 3-D plate and two straight miniplates were equally effective for the surgical management of mandibular subcondylar fractures. Although a 3-D plate is sufficient for a typical simple fracture, in cases with a bone defect around the fracture, selection of the plate fixation method should be carefully considered.

    DOI: 10.1016/j.jcms.2019.01.033

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  • What are the risk factors for postoperative infections of third molar extraction surgery: A retrospective clinical study?

    Shintaro Sukegawa, Kyoko Yokota, Takahiro Kanno, Yoshiki Manabe, Yuka Sukegawa-Takahashi, Masanori Masui, Yoshihiko Furuki

    MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL   24 ( 1 )   E123 - E129   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MEDICINA ORAL S L  

    Background: This study aimed to identify (1) the predilection site of postoperative infection after third molar extraction surgery, (2) risk factors associated with postoperative infection, and (3) the cause of the difference between delayed- and early-onset infections.Material and Methods: This retrospective study included 1010 patients (396 male, 614 female) who had >= 1 third molars extracted (2407; 812 maxilla, 1595 mandible). The risk factors were classified as attributes, general health, anatomic, and operative. Outcome variables were delayed- and early-onset infections.Results: Postoperative infection was completely absent in the maxilla, and all infections occurred in the mandible, with a probability of 1.94% (31/1595). Bivariate analysis for postoperative infection showed depth of inclusion and intraoperative hemostatic treatment to be significantly associated with the development of infections. Bivariate analysis for delayed- and early-onset infections showed simultaneous extraction of the left and right mandibular third molars to be prominent risk factors.Conclusions: Postoperative infection occurs mainly in the mandible. and that in the maxilla is very rare. The risk of postoperative infection in the mandible was found to be related to the depth of inclusion and intraoperative hemostatic treatment. Simultaneous extraction of the left and right mandibular third molars appear to increase the risk of delayed-onset postoperative infection.

    DOI: 10.4317/medoral.22556

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  • Retinoic Receptor Signaling Regulates Hypertrophic Chondrocyte-specific Gene Expression

    Tsuyoshi Shimo, Eiki Koyama, Tatsuo Okui, Masanori Masui, Yuki Kunisada, Soichiro Ibaragi, Norie Yoshioka, Naito Kurio, Shoko Yoshida, Akira Sasaki, Masahiro Iwamoto

    IN VIVO   33 ( 1 )   85 - 91   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INT INST ANTICANCER RESEARCH  

    Background/Aim: Retinoid signaling is important for the maturation of growth-plate chondrocytes. The effect of retinoid receptor gamma (RAR gamma) signaling on the expression of genes in hypertrophic chondrocytes is unclear. This study investigated the role of RAR gamma signaling in regulation of hypertrophic chondrocyte-specific genes. Materials and Methods: The gene expression in mouse E17.5 tibial cartilage was examined by in situ hybridization analysis. Real-time reverse transcription-polymerase chain reaction (RT-PCR) and immunoblotting were used for analysis of mRNA and phosphorylated mitogen-activated protein kinase (MAPK). Results: mRNA expression of Rarg and connective tissue growth factor (Ccn2) was detected in maturing chondrocytes throughout the cartilaginous skeletal elements. In chondrogenic ATDC5 cells, an RAR gamma agonist induced the gene expression of type-X collagen (Col10A1), transglutaminase-2 (Tg2), matrix metalloproteinase-13 (Mmp13), and Ccn2 mRNA, whereas a retinoic acid pan-agonist suppressed RAR gamma agonist-stimulated gene expression. Phosphorylated extracellular signal regulated-kinases (pERK1/2), p-p38, and phosphorylated c-Jun N-terminal kinase (pJNK) MAPK were time-dependently increased by RAR gamma agonist treatment. Experimental p38 inhibition led to a severe drop in the RAR gamma agonist-stimulated expressions of Col10A1, Tg2, Mmp13, and Ccn2 mRNA. Conclusion: RARy signaling is required for the differentiation of hypertrophic chondrocytes, with differential cooperation with p38 MAPK.

    DOI: 10.21873/invivo.11443

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  • Endoscope-Assisted Resection of Intramuscular Cavernous Hemangioma Within the Temporal Muscle. 国際誌

    Tsukasa Kishimoto, Shintaro Sukegawa, Naoki Katase, Takahiro Kanno, Yuka Sukegawa-Takahashi, Masanori Masui, Ai Sato, Yoshihiko Furuki

    The Journal of craniofacial surgery   30 ( 1 )   193 - 195   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Hemangiomas are benign vascular soft tissue tumors, which most frequently occur in the skin or subcutaneous tissue. Intramuscular hemangiomas typically occur in the trunk and extremities and less frequently in the head and neck. Among these, those occurring in the temporalis muscle are extremely rare. The authors report the case of a 43-year-old Japanese male with a mass in his left temporal fossa. Computed tomography images showed no erosion of the zygomatic bone, and magnetic resonance imaging revealed an ovoid well-marginated mass within the temporal muscle. The lesion was surgically excised with an endoscopy procedure used for minimally invasive lesions and complete removal. Histopathological examination confirmed the diagnosis of intramuscular cavernous hemangioma. The postoperative clinical course was good, with no indications of temporary nerve paralysis. No signs of local recurrence were observed postoperatively. Therefore, a cavernous hemangioma should be suspected when a mass occurs in the temporal region with accompanying radiologic findings suggesting vascular origin. In surgical treatment, the endoscopy-assisted technique is very useful to achieve complete tumor resection and prevent relapse while avoiding serious complications due to surgical procedures.

    DOI: 10.1097/SCS.0000000000004933

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  • Is the removal of osteosynthesis plates after orthognathic surgery necessary? Retrospective long-term follow-up study

    S. Sukegawa, T. Kanno, Y. Manabe, K. Matsumoto, Y. Sukegawa-Takahashi, M. Masui, Y. Furuki

    International Journal of Oral and Maxillofacial Surgery   47 ( 12 )   1581 - 1586   2018年12月

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    掲載種別:研究論文(学術雑誌)  

    The removal of titanium miniplates is a controversial topic in oral and maxillofacial surgery. This retrospective study examined the timing of and reasons for titanium plate removal after orthognathic surgery. The study included 240 orthognathic surgery patients (71 male, 169 female; age range 16–55 years, mean 25.0 ± 8.8 years) who had maxillofacial osteosynthesis plates inserted or inserted and then removed at the Division of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, between April 2003 and March 2017. During the study period, a total of 717 miniplates were inserted in the 240 patients, and 71 of the patients (29.6%) had 236 plates (32.9%) removed. Ten patients (14.1%) had their plates removed within a year due to early complications. Although no patient had their plate removed due to complications at 1–5 years postoperative, a further 14 patients (19.7%) had their plates removed after more than 5 years of long-term follow-up due to plate-related complications. Complications requiring plate removal were evidently biphasic, occurring within 1 year after the operation and at ≥5 years after the operation. Therefore, after confirming postoperative bone healing, it is necessary to explain to patients the risks of plate removal and the importance of long-term follow-up.

    DOI: 10.1016/j.ijom.2018.07.001

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  • Complications of a poly-L-lactic acid and polyglycolic acid osteosynthesis device for internal fixation in maxillofacial surgery.

    Shintaro Sukegawa, Takahiro Kanno, Kenichi Matsumoto, Yuka Sukegawa-Takahashi, Masanori Masui, Yoshihiko Furuki

    Odontology   106 ( 4 )   360 - 368   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The purpose of this study was to retrospectively evaluate and examine the incidence of complications using poly-L-lactic acid and polyglycolic acid (PLLA/PGA) copolymer plate system in maxillofacial osteosynthesis. The retrospective study included 87 patients (50 men, 37 women), who needed maxillofacial surgery. We examined the proportion of complications and their factors from clinical data. A comparison was also made for plate decomposition using the molecular weight of the plate without plate exposure and complications. Osteosynthesis sites healed in all patients. Ten cases (11.5%) showed plate exposure-related complications, with all occurring at intraoral surgical sites. There was no significant difference in molecular weight changes of plates in resorbable process. Statistical analysis of study variables between patients with and without exposed plates showed that the plate thickness was significantly associated with the risk of exposed plates (p < 0.05). The commercially available PLLA/PGA device could be a useful rapid resorbable material for maxillofacial osteosynthesis. When thick plates are used on the intraoral site, it may be necessary to pay attention to the complication of plate exposure. Even if exposure-related complications have occurred, resorption and degradation of this material proceeds, suggesting the ease of appropriate risk management.

    DOI: 10.1007/s10266-018-0345-6

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  • Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling. 国際誌

    Kenichi Matsumoto, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, Soichiro Ibaragi, Yuki Kunisada, Kyoichi Obata, Masanori Masui, Pang Pai, Yuu Horikiri, Nobuyuki Yamanaka, Masaharu Takigawa, Akira Sasaki

    Journal of cellular biochemistry   119 ( 6 )   4352 - 4360   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Low-intensity pulsed ultrasound (LIPUS) has been used as an adjunct to fracture healing therapies, but the mechanisms underlying its action are not known. We reported that sonic hedgehog (SHH) signaling was activated in osteoblasts at the dynamic remodeling site of a bone fracture. Mechanical stimulation is a crucial factor in bone remodeling, and it is related to the primary cilia as a sensor of hedgehog signaling. Here we observed that LIPUS promoted callus formation in accord with Gli2-positive cells after 14 days at the mouse femur fractured site compared with a control group. An immunofluorescence analysis showed that the numbers of primary cilia and cilia/osterix double-positive osteoblasts were increased at the fracture site by LIPUS. LIPUS stimulated not only the number and the length of primary cilia, but also the levels of ciliated protein, Ift88 mRNA, and SHH, Gli1, and Gli2 in MC3T3-E1 cells. Further experiments revealed that LIPUS stimulated osteogenic differentiation in the presence of smoothened agonist (SAG) treatment. These results indicate that LIPUS stimulates osteogenic differentiation and the maturation of osteoblasts by a primary cilium-mediated activation of hedgehog signaling.

    DOI: 10.1002/jcb.26418

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  • Retrospective clinical study of dental implants following sinus floor elevation: An up-to-10-year follow-up evaluation

    Kanno Takahiro, Sukegawa Shintaro, Masui Masanori, Kishimoto Tsukasa, Sato Ai, Sekine Joji, Furuki Yoshihiko, Sukegawa-Takahashi Yuka

    バイオインテグレーション学会誌   8 ( 1 )   83 - 93   2018年

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    記述言語:英語   出版者・発行元:一般社団法人 バイオインテグレーション学会  

    Purpose: Various maxillary sinus floor elevation techniques are used together with augmentation proceduresfor oral rehabilitation. Dental implants with or without bone substitutes or autologous bone grafting, and appliedusing the lateral window technique or the transcrestal osteotome-mediated sinus floor elevation technique, areused to enhance bone stability for implant installation. The aim of this study was to retrospectively evaluate theimplant status of patients who had undergone maxillary sinus floor elevation and immediate or delayed implantplacement via such techniques, with or without graft materials.Materials and Methods: In total, 398 dental implants placed in 169 maxillary sinuses of 169 patients (106 females,63 males; mean age, 57.5 years), who were fitted with Astra Tech dental implants, and required maxillary sinusfloor elevation, were evaluated in terms of the amount of residual bone remaining following treatment; the residualbone was assessed by elevation technique subgroup. The vertical height of the residual maxillary alveolarbone and the augmented vertical bone height were analyzed using digitalized panoramic radiographs. Clinicaland radiological follow-up was carried out over a period of 120 months after functional loading of a fixed prosthesis.The mean follow-up period was 55 months.Results: In total, 277 implants, with a mean residual vertical bone height of 3.72 mm, were installed in 113 maxillarysinuses using the lateral window technique. Of these, 216 implants (mean vertical bone height, 4.87 mm)were installed in 96 sinuses simultaneous with sinus floor elevation using β-tricalcium phosphate (βTCP) using nograft material or intraoral autologous bone. The remaining 17 sinuses underwent 61 implants (mean vertical boneheight, 2.57 mm) according to a delayed installation schedule using βTCP or iliac autologous bone. In 56 sinuses,121 implants (mean vertical height, 8.60 mm) were installed simultaneous via the transcrestal osteotome-mediatedtechnique with βTCP. Although seven implants failed (three early and four late failures) over a follow-up periodof 120 months (mean follow-up, 55 months), the other implants remained stable, with a high survival rate of 98.2%.No elevation technique or graft material subgroup showed any statistical significance, and complications wereminimal.Conclusions: The findings of this study demonstrate that various maxillary sinus floor elevation techniques forimplant installation, with or without graft material, are safe, having low complication rates and yielding predictableresults.

    DOI: 10.32176/biointeg.8.1_83

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  • Oral Squamous Cell Carcinoma-derived Sonic Hedgehog Promotes Angiogenesis. 国際誌

    Hiromasa Kuroda, Naito Kurio, Tsuyoshi Shimo, Kenichi Matsumoto, Masanori Masui, Kiyofumi Takabatake, Tatsuo Okui, Soichiro Ibaragi, Yuki Kunisada, Kyoichi Obata, Norie Yoshioka, Koji Kishimoto, Hitoshi Nagatsuka, Akira Sasaki

    Anticancer research   37 ( 12 )   6731 - 6737   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS: We examined the expression pattern of SHH and its signal proteins in clinically resected OSCC samples by immunohistochemistry. We also evaluated the function of SHH signaling using the hedgehog signaling inhibitor cyclopamine in vivo and in vitro by proliferation, migration and angiogenesis analyses. RESULTS: We found that SHH was highly expressed in human tongue OSCC, whereas patched (PTCH1), glioma-associated oncogene 1 (GLI1) and GLI2 proteins were expressed in the microvascular cells in the tumor invasive front. Administration of cyclopamine to mice suppressed the growth and angiogenesis of OSCC xenografts in vivo. Moreover, cyclopamine inhibited endothelial cell proliferation and migration, and reduced aorta vascular length in the rat. CONCLUSION: These findings suggest that OSCC-derived SHH stimulates angiogenesis at the tumor invasive front.

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  • Use of an intraoperative navigation system and piezoelectric surgery for styloidectomy in a patient with Eagle's syndrome: a case report. 国際誌

    Shintaro Sukegawa, Takahiro Kanno, Akio Yoshimoto, Kenichi Matsumoto, Yuka Sukegawa-Takahashi, Masanori Masui, Yoshihiko Furuki

    Journal of medical case reports   11 ( 1 )   322 - 322   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Elongated styloid process syndrome (Eagle's syndrome) is the term given to the symptomatic elongation of the styloid process or the mineralization of the stylohyoid or stylomandibular ligament. The two commonly used approaches for the surgical treatment of this syndrome are the transcervical and transoral approaches. Both have their limitations and specific intraoperative risks. Here, we report the treatment of a patient with Eagle's syndrome using the transoral approach in conjunction with piezoelectric surgery, surgical planning, and intraoperative navigation to reduce the risk of complications. CASE PRESENTATION: The elongated styloid process was resected in a 45-year-old Japanese man using a minimally invasive approach with an intraoperative navigation system. Preoperative preparation involved the use of a custom interocclusal splint to produce the mouth opening conditions required during surgery. Using the three-dimensional position of the navigation probe, the location of the elongated styloid process was identified. After confirmation of the resection spot via the transoral approach, the styloid process was dissected by piezoelectric surgery. Follow-up examination showed an uneventful recovery with no associated complications. CONCLUSION: The resection of the styloid process using an intraoperative navigation system and a custom interocclusal splint during a transoral approach, together with a piezoelectric cutting device, is safe and effective for the treatment of Eagle's syndrome.

    DOI: 10.1186/s13256-017-1464-3

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  • Pathological and Clinical Study of Japanese Ameloblastic Fibro-Odontomas

    Shintaro Sukegawa, Keisuke Nakano, Takahiro Kanno, Hotaka Kawai, Kenichi Matsumoto, Yuka Sukegawa-Takahashi, Masanori Masui, Yoshihiko Furuki

    JOURNAL OF HARD TISSUE BIOLOGY   26 ( 4 )   425 - 430   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JOURNAL HARD TISSUE BIOLOGY  

    Ameloblastic fibro-odontoma (AFO) is defined as a tumor with general characteristics of an ameloblastic fibroma along with the presence of enamel and dentine. AFO is a well-encapsulated, painless, slow-growing, and expanding tumor in young patients. Histologically, it has been classified as an ameloblastic fibroma or odontoma. In the 2017 new WHO classification of odontogenic tumor, AFO is described that they in most cases represent developmental stages of either complex or compound odontoma and that retaining them as separate entities would therefore be illogical. However, there is still considerable confusion concerning the nature and histology of AFO and the surgical therapy for this lesion. Here we present a case of maxillary AFO and review the relevant literature regarding the clinical and surgical features of this lesion.

    DOI: 10.2485/jhtb.26.425

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  • Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma. 国際誌

    Hiroyuki Takada, Soichiro Ibaragi, Takanori Eguchi, Tatsuo Okui, Kyoichi Obata, Masanori Masui, Ayaka Morisawa, Kiyofumi Takabatake, Hotaka Kawai, Norie Yoshioka, Nur Mohammad Monsur Hassan, Tsuyoshi Shimo, Guo-Fu Hu, Hitoshi Nagatsuka, Akira Sasaki

    International journal of oncology   51 ( 2 )   625 - 632   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Head and neck squamous cell carcinomas (HNSCCs) frequently invade the bones of the facial skeleton. Semaphorin 4D (Sema4D) is an axon guidance molecule produced by oligodendrocytes. Sema4D was also identified in the bone microenvironment and many cancer tissues including HNSCC. To date, however, the role of Sema4D in cancer-associated bone disease is still unknown. This is the first study to demonstrate the role of Sema4D in bone invasion of cancer. In the clinical tissue samples of bone lesion of HNSCC, Sema4D was detected at high levels, and its expression was correlated with insulin-like growth factor-I (IGF-I) expression. In vitro experiments showed that IGF-I regulates Sema4D expression and Sema4D increased proliferation, migration and invasion in HNSCC cells. Sema4D also regulated the expression of receptor activator of nuclear factor κβ ligand (RANKL) in osteoblasts, and this stimulated osteoclastgenesis. Furthermore, knockdown of Sema4D in HNSCC cells inhibited tumor growth and decreased the number of osteoclasts in a mouse xenograft model. Taken together, IGF-I-driven production of Sema4D in HNSCCs promotes osteoclastogenesis and bone invasion.

    DOI: 10.3892/ijo.2017.4050

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  • Biomechanical Loading Evaluation of Unsintered Hydroxyapatite/poly-l-lactide Plate System in Bilateral Sagittal Split Ramus Osteotomy. 国際誌

    Shintaro Sukegawa, Takahiro Kanno, Yoshiki Manabe, Kenichi Matsumoto, Yuka Sukegawa-Takahashi, Masanori Masui, Yoshihiko Furuki

    Materials (Basel, Switzerland)   10 ( 7 )   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OSTEOTRANS MX® (Takiron Co., Ltd., Osaka, Japan) is a bioactive resorbable maxillofacial osteosynthetic material composed of an unsintered hydroxyapatite/poly-l-lactide composite, and its effective osteoconductive capacity has been previously documented. However, the mechanical strength of this plate system is unclear. Thus, the aim of this in vitro study was to assess its tensile and shear strength and evaluate the biomechanical intensity of different osteosynthesis plate designs after sagittal split ramus osteotomy by simulating masticatory forces in a clinical setting. For tensile and shear strength analyses, three mechanical strength measurement samples were prepared by fixing unsintered hydroxyapatite/poly-l-lactide composed plates to polycarbonate skeletal models. Regarding biomechanical loading evaluation, 12 mandibular replicas were used and divided into four groups for sagittal split ramus osteotomy fixation. Each sample was secured in a jig and subjected to vertical load on the first molar teeth. Regarding shear strength, the novel-shaped unsintered hydroxyapatite/poly-l-lactide plate had significantly high intensity. Upon biomechanical loading evaluation, this plate system also displayed significantly high stability in addition to bioactivity, with no observed plate fracture. Thus, we have clearly demonstrated the efficacy of this plate system using an in vitro model of bilateral sagittal split ramus osteotomy of the mandible.

    DOI: 10.3390/ma10070764

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  • Precision of Post-Traumatic Orbital Reconstruction Using Unsintered Hydroxyapatite Particles/Poly-L-Lactide Composite Bioactive/Resorbable Mesh Plate with and without Navigation: A Retrospective Study

    Shintaro Sukegawa, Takahiro Kanno, Yuta Koyama, Kenichi Matsumoto, Yuka Sukegawa-Takahashi, Masanori Masui, Shigeto Tanaka, Yoshihiko Furuki

    JOURNAL OF HARD TISSUE BIOLOGY   26 ( 3 )   274 - 279   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JOURNAL HARD TISSUE BIOLOGY  

    The purpose of this study was to assess the level of accuracy that can be achieved in patients undergoing orbital reconstruction for orbital floor defect accompanied by midfacial fracture using an unsintered hydroxyapatite particles/poly-L-lactide composite plate system with and without the use of intraoperative navigation. Eight consecutive patients treated using the u-HA/PLLA mesh plate system between 2014 and 2016 were included in this retrospective study. We analyzed the clinical and radiological data of these patients with orbital floor defect and midfacial fracture extending to the orbit. We examined the patients' postoperative healing status, including visual activity, diplopia, and enophthalmos. The overall volume of the orbit was calculated in cubic millimeter sand was compared between the reconstructed orbit and the uninjured orbit for with and without the use of navigation groups. No patients complained of visual problems, and no further treatment was required postoperatively. Except for one patient with persistence of slight supraversion diplopia in the group without navigation, all the preoperative diplopia symptoms postoperatively improved, and none of the patients complained of problems in daily living. There was a significant difference (p < 0.05) in the mean reconstructed orbital volume accuracy between with and without navigation. In conclusion, complex orbital reconstruction using optimal bioactive/resorbable material with intraoperative navigation is an accurate and reliable method of reconstruction.

    DOI: 10.2485/jhtb.26.274

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  • Orthognathic surgery during breast cancer treatment-A case report. 国際誌

    Tsuyoshi Shimo, Norie Yoshioka, Masahiro Nakamura, Soichiro Ibaragi, Tatsuo Okui, Yuki Kunisada, Masanori Masui, Mayumi Yao, Koji Kishimoto, Shoko Yoshida, Akiyoshi Nishiyama, Hiroshi Kamioka, Akira Sasaki

    International journal of surgery case reports   31   30 - 34   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: In recent years, patients with orthognathic surgery in middle-aged and elderly people have come to be a more frequent occurrence. Breast cancer is the most frequently diagnosed cancer in woman worldwide, and its prevalence rate is steadily increasing. PRESENTATION OF CASE: We report a case of a 47-year-old Japanese woman in whom left-side breast cancer (Stage 1) was unexpectedly found just before orthognathic surgery in April 2012. Breast-conserving surgery was performed (estrogen receptor+, progesterone receptor+, HER2 -, surgical margin+, sentinel lymph node +) that May. From June to August docetaxel (75mg/m2) and cyclophosphamide (600mg/m2) were administrated four times every 21days and thereafter radiotherapy (total 60Gy) was completed. The cancer surgeon declared the prognosis good and the patient had a strong desire to undergo orthognathic surgery, so in November we performed a bimaxillary osteotomy, and administration of tamoxifen began 6 weeks after the osteotomy. DISCUSSION: There are breast cancer cases in which the prognosis is sufficiently good for a planned orthognathic surgery to proceed. Good communication among surgeons and the patient is important. CONCLUSION: We experienced a case in which breast cancer was found just before the orthognathic surgery; we performed a bimaxillary osteotomy, including follow-up tamoxifen administration, during breast cancer treatment.

    DOI: 10.1016/j.ijscr.2016.12.014

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  • Expression and Role of Sonic Hedgehog in the Process of Fracture Healing with Aging

    Kenichi Matsumoto, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, Kyoichi Obata, Masanori Masui, Pai Pang, Yuu Horikiri, Akira Sasaki

    IN VIVO   30 ( 2 )   99 - 105   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INT INST ANTICANCER RESEARCH  

    Aging is one of the risk factors for delayed fracture healing. Sonic hedgehog (SHH) protein, an inducer of embryonic development, has been demonstrated to be activated in osteoblasts at the dynamic remodeling site of a bone fracture. Herein, we compared and examined the distribution patterns of SHH and the functional effect of SHH signaling on osteogenesis and osteoclastogenesis between young (5-week-old) and aged (60-week-old) mice during fracture healing. We found that SHH was expressed in bone marrow cells from the fractured site of the rib of young mice on day 5, but was barely detectable in the corresponding cells from the rib of aged mice. SHH was also detected in osteoblasts and bone marrow cells at the callus remodeling stage on days 14 and 28 in both young and aged mice. The number of alkaline phosphatase (ALP)-positive osteoblasts was significantly higher in young mice on days 5 and 14, whereas the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts was significantly higher in aged mice. SHH stimulated significantly more osteoblast formation in the young compared to old mice. SHH stimulated the osteoclast formation directly in the aged mice and suppressed the formation indirectly through osteoprotegerin expression in the young mice. Results indicate that an aged-related delay of fracture healing may contribute to the unbalanced bone formation and resorption, regulated by hedgehog signaling.

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  • Detection of sonic hedgehog in patients undergoing orthognathic surgery

    Yuki Kunisada, Tsuyoshi Shimo, Masanori Masui, Norie Yoshioka, Soichiro Ibaragi, Kenichi Matsumoto, Tatsuo Okui, Naito Kurio, Shohei Domae, Koji Kishimoto, Akiyoshi Nishiyama, Akira Sasaki

    INTERNATIONAL JOURNAL OF SURGERY OPEN   5   1 - 4   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Purpose: Sonic Hedgehog (SHH) is a regulatory protein involved in bone fracture healing. Orthognathic surgery involves surgical osteotomy of the mandible or maxilla to restore the proper anatomic and functional position in patients with dentofacial deformity. The purpose of this study was to analyze SHH local blood serum concentrations after osteotomy to gain further understanding of the molecular regulation of the initial stage of osteotomy healing.Methods: Serum samples (local drainage and peripheral venous) of 34 patients (24 females and 10 males, mean age was 23.4 (16-42) years) who underwent orthognathic surgery were isolated from patients at different time points during the perioperative period. The levels of SHH, soluble receptor activator of nuclear factor-kappa B ligand (sRANKL) and osteoprotegerin (OPG) were measured using ELISA.Results: SHH was detected in the local drainage immediately after osteotomy (309.5 +/- 58.2 pg/ml), and decreased for 2 days after the operation (197.5 +/- 43.6 pg/ml). The sRANKL local serum concentrations were at the maximum level immediately after the operation (141.4 +/- 22.6 pg/ml) and decreased for 2 days (110.1 +/- 23.4 pg/ml). On the other hand, the OPG concentration in the local serum was at a minimum after osteotomy (59.4 +/- 4.6 pg/ml) and reached its maximum (181.5 +/- 17.8 pg/ml, P < 0.01) at 2 days after osteotomy. SHH and OPG local serum levels on day 2 were associated with the amount of bleeding during the operation. The local drainage serum level of SHH of maxillary/mandibular osteotomy had a tendency to be higher than that of mandible-only osteotomy at 2 days after operation.Conclusions: Elevated levels of SHH in local serum after osteotomy, especially during the initial stage of healing, indicates its importance in osteotomy healing. (c) 2016 The Authors. Published by Elsevier Ltd on behalf of Surgical Associates Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia. 国際誌

    Yuko Ono, Tsuyoshi Shimo, Yoshinori Shirafuji, Toshihisa Hamada, Masanori Masui, Kyoichi Obata, Mayumi Yao, Koji Kishimoto, Akira Sasaki

    Case reports in dentistry   2016   4605231 - 4605231   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6 (HHV-6) IgG, and CMV-HRP were negative. Oral prednisolone therapy was begun 18 days later. The titer of HHV-6 IgG antibodies was then detected (640 times). Following treatment, liver and renal function improved and the erythema disappeared.

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▼全件表示

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  • HMGB1は進行期頭頸部癌モデルマウスにおいて癌性骨痛を誘発する

    中村 友哉, 奥井 達雄, 竜門 省二, 小野 喜章, 小畑 協一, 増井 正典, 伊原木 聰一郎, 佐々木 朗

    日本口腔科学会雑誌  2021年7月  (NPO)日本口腔科学会

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    開催年月日: 2021年7月

    記述言語:日本語  

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    坂本 裕美, 奥井 達雄, 竜門 省二, 中村 友哉, 國定 勇希, 増井 正典, 小野 喜章, 小畑 協一, 伊原木 聰一郎, 佐々木 朗

    日本口腔科学会雑誌  2021年7月  (NPO)日本口腔科学会

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    開催年月日: 2021年7月

    記述言語:日本語  

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  • 根治的頸部郭清術後に後頭リンパ節転移をきたした舌癌の一例

    小野 喜章, 吉岡 徳枝, 小畑 協一, 増井 正典, 岸本 晃治, 伊原木 聰一郎, 長塚 仁, 佐々木 朗

    頭頸部癌  2021年5月  (一社)日本頭頸部癌学会

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    開催年月日: 2021年5月

    記述言語:日本語  

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  • 過去15年間の外科的歯列拡大に関する検討

    吉岡 徳枝, 西山 明慶, 竜門 省二, 増井 正典, 小畑 協一, 伊原木 聰一郎, 佐々木 朗

    日本顎変形症学会雑誌  2021年5月  (NPO)日本顎変形症学会

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    開催年月日: 2021年5月

    記述言語:日本語  

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  • 悪性黒色腫に対する新規血管新生阻害薬terreinの抗腫瘍効果の検討

    伊原木 聰一郎, 小野 喜章, 小畑 協一, 増井 正典, 吉岡 徳枝, 佐々木 朗

    頭頸部癌  2021年5月  (一社)日本頭頸部癌学会

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    開催年月日: 2021年5月

    記述言語:日本語  

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  • 口腔領域に発生したEBV-positive mucocutaneous ulcerに関する統計学的検討

    小畑 協一, 伊原木 聰一郎, 小野 喜章, 増井 正典, 矢尾 真弓, 岸本 晃治, 吉岡 徳枝, 佐々木 朗

    頭頸部癌  2021年5月  (一社)日本頭頸部癌学会

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    開催年月日: 2021年5月

    記述言語:日本語  

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  • 顎骨壊死を伴ったEBV陽性皮膚粘膜潰瘍(EBV-MCU)の2例

    竜門 省二, 岸本 晃治, 奥井 達雄, 吉岡 徳枝, 小畑 協一, 國定 勇希, 増井 正典, 小野 喜章, 伊原木 聰一郎, 佐々木 朗

    日本口腔診断学会雑誌  2021年2月  (一社)日本口腔診断学会

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    開催年月日: 2021年2月

    記述言語:日本語  

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  • 顎骨壊死を伴ったEBV陽性皮膚粘膜潰瘍(EBV-MCU)の2例

    竜門 省二, 岸本 晃治, 奥井 達雄, 吉岡 徳枝, 小畑 協一, 國定 勇希, 増井 正典, 小野 喜章, 伊原木 聰一郎, 佐々木 朗

    日本口腔内科学会雑誌  2020年12月  (一社)日本口腔内科学会

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    開催年月日: 2020年12月

    記述言語:日本語  

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  • 顎顔面外傷手術治療における非焼成ハイドロキシアパタイト/ポリL乳酸配合骨接合材吸収性プレートの有用性と合併症の検討

    助川 信太郎, 管野 貴浩, 増井 正典, 助川 由佳, 岸本 司, 佐藤 愛, 古木 良彦

    日本口腔科学会雑誌  2020年7月  (NPO)日本口腔科学会

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    開催年月日: 2020年7月

    記述言語:日本語  

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  • 悪性腫瘍における広範囲顎骨支持型装置のインプラント体脱落に関する検討

    佐藤 愛, 助川 信太郎, 管野 貴浩, 助川 由佳, 増井 正典, 岸本 司, 雑賀 将斗, 古木 良彦

    Japanese Journal of Maxillo Facial Implants  2019年11月  (公社)日本顎顔面インプラント学会

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    開催年月日: 2019年11月

    記述言語:日本語  

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  • インプラント撤去に関する臨床的検討

    助川 信太郎, 管野 貴浩, 助川 由佳, 増井 正典, 岸本 司, 佐藤 愛, 雑賀 将斗, 古木 良彦

    Japanese Journal of Maxillo Facial Implants  2019年11月  (公社)日本顎顔面インプラント学会

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    開催年月日: 2019年11月

    記述言語:日本語  

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  • 頬骨骨折手術におけるcomputer assisted surgeryによる治療経験

    増井 正典, 助川 信太郎, 管野 貴浩, 助川 由佳, 岸本 司, 佐藤 愛, 雑賀 将斗, 古木 良彦

    口腔顎顔面外傷  2019年10月  日本口腔顎顔面外傷学会

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    開催年月日: 2019年10月

    記述言語:日本語  

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  • 下顎骨骨折患者における気道管理の検討

    助川 信太郎, 管野 貴浩, 増井 正典, 助川 由佳, 岸本 司, 佐藤 愛, 雑賀 将斗, 古木 良彦

    口腔顎顔面外傷  2019年10月  日本口腔顎顔面外傷学会

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    開催年月日: 2019年10月

    記述言語:日本語  

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  • 下顎骨関節突起骨折観血的整復固定術におけるSubcondylar Platesの臨床的検討

    助川 信太郎, 管野 貴浩, 助川 由佳, 増井 正典, 岸本 司, 佐藤 愛, 古木 良彦

    日本口腔科学会雑誌  2019年7月  (NPO)日本口腔科学会

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    開催年月日: 2019年7月

    記述言語:日本語  

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  • レチノイド受容体シグナルは肥大軟骨細胞特異的遺伝子制御に関わる

    志茂 剛, 奥井 達雄, 増井 正典, 國定 勇希, 伊原木 聰一郎, 吉岡 徳枝, 栗尾 奈愛, 吉田 祥子, 佐々木 朗, 小山 英樹, 岩本 容泰

    日本口腔科学会雑誌  2019年7月  (NPO)日本口腔科学会

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    開催年月日: 2019年7月

    記述言語:日本語  

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  • 上顎洞根治術における硬性内視鏡の有用性

    増井 正典, 助川 信太郎, 管野 貴浩, 助川 由佳, 岸本 司, 佐藤 愛, 古木 良彦

    日本口腔科学会雑誌  2019年3月  (NPO)日本口腔科学会

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    開催年月日: 2019年3月

    記述言語:日本語  

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  • ナビゲーションシステムを用いたbone lid surgeryによる埋伏歯抜歯を行った1例

    佐藤 愛, 助川 信太郎, 管野 貴浩, 助川 由佳, 増井 正典, 岸本 司, 古木 良彦

    日本口腔科学会雑誌  2019年3月  (NPO)日本口腔科学会

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    開催年月日: 2019年3月

    記述言語:日本語  

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  • Computer-assisted surgeryによる頬骨骨折治療の経験

    岸本 司, 助川 信太郎, 管野 貴浩, 助川 由佳, 増井 正典, 佐藤 愛, 古木 良彦

    日本口腔科学会雑誌  2019年3月  (NPO)日本口腔科学会

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    開催年月日: 2019年3月

    記述言語:日本語  

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  • 非焼成ハイドロキシアパタイト/ポリL乳酸配合スクリューを用いた下顎皮質骨ブロック骨移植による骨造成術後の組織学的検討

    助川 信太郎, 管野 貴浩, 増井 正典, 古木 良彦

    Japanese Journal of Maxillo Facial Implants  2018年11月  (公社)日本顎顔面インプラント学会

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    開催年月日: 2018年11月

    記述言語:日本語  

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  • 上顎洞底挙上術を併用した歯科インプラント治療後の予後に関する後方視的臨床研究(Retrospective clinical study of dental implants following sinus floor elevation: An up-to-10-year follow-up evaluation)

    管野 貴浩, 助川 信太郎, 狩野 正明, 増井 正典, 古木 良彦

    Japanese Journal of Maxillo Facial Implants  2018年11月  (公社)日本顎顔面インプラント学会

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    開催年月日: 2018年11月

    記述言語:英語  

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  • 顎顔面外傷後の骨接合材抜去に関する検討

    助川 信太郎, 管野 貴浩, 増井 正典, 助川 由佳, 岸本 司, 佐藤 愛, 古木 良彦

    口腔顎顔面外傷  2018年10月  日本口腔顎顔面外傷学会

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    開催年月日: 2018年10月

    記述言語:日本語  

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  • 下顎骨関節突起骨折に用いたSubcondylar Plateの術後破折を経験した一例

    増井 正典, 助川 信太郎, 管野 貴浩, 助川 由佳, 岸本 司, 佐藤 愛, 古木 良彦

    口腔顎顔面外傷  2018年10月  日本口腔顎顔面外傷学会

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    開催年月日: 2018年10月

    記述言語:日本語  

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  • ハイブリッド手術室での手術が有用であった下顎骨骨折の一例

    増井 正典, 助川 信太郎, 管野 貴浩, 助川 由佳, 岸本 司, 佐藤 愛, 古木 良彦

    口腔顎顔面外傷  2018年10月  日本口腔顎顔面外傷学会

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    開催年月日: 2018年10月

    記述言語:日本語  

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  • 下顎骨骨折観血的整復固定術における骨接合プレート選択の検討

    助川 信太郎, 管野 貴浩, 助川 由佳, 増井 正典, 岸本 司, 佐藤 愛, 古木 良彦

    口腔顎顔面外傷  2018年10月  日本口腔顎顔面外傷学会

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    開催年月日: 2018年10月

    記述言語:日本語  

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  • 顎顔面外傷手術治療におけるPLLA/PGA吸収性プレートの有用性と合併症の検討

    助川 信太郎, 管野 貴浩, 松本 憲一, 助川 由佳, 増井 正典, 古木 良彦

    日本口腔科学会雑誌  2018年7月  (NPO)日本口腔科学会

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    開催年月日: 2018年7月

    記述言語:日本語  

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  • 岡山大学病院口腔外科(病態系)医科歯科連携におけるMRONJ患者の調査

    坂本 裕美, 志茂 剛, 國定 勇希, 増井 正典, 小畑 協一, 吉岡 徳枝, 矢尾 真弓, 柴田 茜, 伊原木 聰一郎, 奥井 達雄, 吉田 祥子, 村瀬 友里香, 岸本 晃治, 西山 明慶, 佐々木 朗

    日本口腔診断学会雑誌  2018年2月  (一社)日本口腔診断学会

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    開催年月日: 2018年2月

    記述言語:日本語  

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  • 岡山大学病院口腔外科(病態系)医科歯科連携におけるMRONJ患者の調査

    坂本 裕美, 志茂 剛, 國定 勇希, 増井 正典, 小畑 協一, 吉岡 徳枝, 矢尾 真弓, 柴田 茜, 伊原木 聰一郎, 奥井 達雄, 吉田 祥子, 村瀬 友里香, 岸本 晃治, 西山 明慶, 佐々木 朗

    日本口腔内科学会雑誌  2017年12月  (一社)日本口腔内科学会

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    開催年月日: 2017年12月

    記述言語:日本語  

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  • ナビゲーションシステムを用いたサンドイッチグラフト法による下顎臼歯部垂直的骨造成下顎骨垂直的歯槽骨増大術の1例

    松本 憲一, 助川 信太郎, 管野 貴浩, 助川 由佳, 増井 正典, 古木 良彦

    Japanese Journal of Maxillo Facial Implants  2017年11月  (公社)日本顎顔面インプラント学会

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    開催年月日: 2017年11月

    記述言語:日本語  

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  • 非焼成ハイドロキシアパタイト/ポリL乳酸配合骨接合材スクリューを用いた下顎皮質骨ブロック骨移植による水平的骨造成術についての検討

    助川 信太郎, 管野 貴浩, 松本 憲一, 助川 由佳, 増井 正典, 古木 良彦

    Japanese Journal of Maxillo Facial Implants  2017年11月  (公社)日本顎顔面インプラント学会

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    開催年月日: 2017年11月

    記述言語:日本語  

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  • 眼窩骨折に対しu-HA/PLLAメッシュシートを用いた眼窩再建におけるナビゲーションシステムの有用性

    助川 信太郎, 管野 貴浩, 松本 憲一, 助川 由佳, 増井 正典, 古木 良彦

    口腔顎顔面外傷  2017年10月  日本口腔顎顔面外傷学会

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    開催年月日: 2017年10月

    記述言語:日本語  

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  • 口腔扁平上皮癌に対するMidkine阻害剤iMDKを用いた腫瘍抑制効果の検討

    増井 正典, 奥井 達雄, 志茂 剛, 伊原木 聰一郎, 佐々木 朗

    日本口腔科学会雑誌  2017年7月  (NPO)日本口腔科学会

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    開催年月日: 2017年7月

    記述言語:日本語  

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  • 岡山大学病院口腔外科(病態系)において医科歯科連携を行った症例の調査

    増井 正典, 志茂 剛, 吉岡 徳枝, 伊原木 聰一郎, 矢尾 真弓, 奥井 達雄, 岸本 晃治, 西山 明慶, 佐々木 朗

    日本口腔診断学会雑誌  2017年2月  (一社)日本口腔診断学会

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    開催年月日: 2017年2月

    記述言語:日本語  

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  • 岡山大学病院口腔外科(病態系)において医科歯科連携を行った症例の調査

    増井 正典, 志茂 剛, 吉岡 徳枝, 伊原木 聰一郎, 矢尾 真弓, 奥井 達雄, 岸本 晃治, 西山 明慶, 佐々木 朗

    日本口腔内科学会雑誌  2016年12月  (一社)日本口腔内科学会

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    開催年月日: 2016年12月

    記述言語:日本語  

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  • 口腔扁平上皮癌の骨破壊におけるSemaphorin4Dの役割

    高田 紘行, 伊原木 聰一郎, 吉岡 徳枝, 増井 正典, 森澤 綾香, 志茂 剛, 佐々木 朗

    日本口腔科学会雑誌  2016年7月  (NPO)日本口腔科学会

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    開催年月日: 2016年7月

    記述言語:日本語  

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  • 外科的矯正治療術後患者における骨代謝マーカーの検討

    國定 勇希, 志茂 剛, 増井 正典, 吉岡 徳枝, 伊原木 聰一郎, 銅前 昇平, 栗尾 奈愛, 奥井 達雄, 西山 明慶, 佐々木 朗

    日本口腔科学会雑誌  2014年9月  (NPO)日本口腔科学会

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    開催年月日: 2014年9月

    記述言語:日本語  

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  • 外科的矯正治療術後患者におけるソニックヘッジホッグの検出

    國定 勇希, 志茂 剛, 栗尾 奈愛, 増井 正典, 伊原木 聰一郎, 奥井 達雄, 西山 明慶, 佐々木 朗

    日本骨代謝学会学術集会プログラム抄録集  2014年7月  (一社)日本骨代謝学会

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    開催年月日: 2014年7月

    記述言語:日本語  

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  • 医療安全講習「香川県立中央病院 歯科・歯科口腔外科での抜歯患者における合併症から学ぶ取り組みについて」

    古木良彦, 助川信太郎, 助川由香, 増井正典

    2020年3月14日 

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▼全件表示

共同研究・競争的資金等の研究

  • 新規成長因子Midkineが口腔癌骨浸潤に果たす役割と機能の解明

    研究課題/領域番号:21K17138  2021年04月 - 2025年03月

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    増井 正典

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    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

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  • 癌骨破壊病変の癌関連線維芽細胞の血管新生・骨吸収調節機構の解析と治療標的の探索

    研究課題/領域番号:26293429  2014年04月 - 2017年03月

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    佐々木 朗, 岸本 晃治, 志茂 剛, 吉岡 徳枝, 伊原木 聰一郎, 奥井 達雄, 森澤 綾香, 増井 正典

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    配分額:14820000円 ( 直接経費:11400000円 、 間接経費:3420000円 )

    癌の骨破壊における骨微小環境の癌関連線維芽細胞は血管新生や破骨細胞の制御に重要と考えられる。骨の癌関連線維芽細胞の網羅的遺伝子解析の結果,RANKLや血管新生因子(VEGF, MMPs, IL-X, TNF, PGEなど)の発現更新を認めた。各種血管新生阻害薬のスクリーニングから,候補となった銅イオンを制御するAmmonium tetrathiomolybdate(TM)は口腔癌骨破壊モデルの破骨細胞形成を抑制し,さらにCetuximabの抗腫瘍効果を増強し骨破壊を抑制した。In vitroでは骨系細胞のRANKLの抑制と血管新生阻害を介して破骨細胞形成を抑制していることが明らかとなった。

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