Updated on 2025/06/26

写真a

 
Uchiyama Jumpei
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
Position
Associate Professor
External link

Degree

  • 博士(医学) ( 高知大学大学院 )

Research Interests

  • ウイルス

  • 細菌

  • 抗菌酵素

  • One Health

  • Microbiome

  • 感染症

  • バクテリオファージ

  • ファージ療法

  • アレルギー

  • 細菌叢

  • 迅速細菌検査法

Research Areas

  • Life Science / Applied microbiology

  • Life Science / Veterinary medical science

  • Life Science / Genetics

  • Life Science / Bacteriology

  • Life Science / Infectious disease medicine

Research History

  • 岡山大学学術研究院医歯薬学域   准教授

    2021.9

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  • 麻布大学獣医学部   准教授

    2021.4 - 2021.8

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  • Azabu University   School of Veterinary Medicine   Lecturer

    2015.4 - 2021.3

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  • Kochi University   医歯学系   Assistant Professor

    2009.12 - 2015.3

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  • Kochi University   短期研究員

    2009.4 - 2009.11

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  • Kochi University   Medical School

    2009.4 - 2009.11

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  • Faculty of Medicien, Bond University, Australia   Research Fellow

    2008.3 - 2008.10

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  • 高知大学大学院医学系研究科   大学院生(博士課程)

    2006.4 - 2009.3

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Professional Memberships

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Committee Memberships

  • 日本ワンヘルスサイエンス学会   評議員  

    2022.10   

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    Committee type:Academic society

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  •   Bacterial viruses subcommittee, International Committee on Taxonomy of Viruses,  

    2017.12   

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    Committee type:Academic society

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  • タイ大国ワライラック大学   博士課程学位審査外部委員  

    2022.12   

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    Committee type:Other

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  •   Grant Reviewer, Science Fund of the Republic of Serbia  

    2021.1   

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    Committee type:Government

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  •   Grant reviewer, Polish academy of sciences  

    2018   

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    Committee type:Government

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  • 日本ブドウ球菌研究会   実行委員  

    2015.4   

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Papers

  • Polyamines and linear DNA mediate bacterial threat assessment of bacteriophage infection. Reviewed International journal

    Camilla D de Mattos, Dominick R Faith, Artem A Nemudryi, Amelia K Schmidt, DeAnna C Bublitz, Lauren Hammond, Margie A Kinnersley, Caleb M Schwartzkopf, Autumn J Robinson, Alex Joyce, Lia A Michaels, Robert S Brzozowski, Alison Coluccio, Denghui David Xing, Jumpei Uchiyama, Laura K Jennings, Prahathees Eswara, Blake Wiedenheft, Patrick R Secor

    Proceedings of the National Academy of Sciences of the United States of America   120 ( 9 )   e2216430120   2023.2

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    DOI: 10.1073/pnas.2216430120

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  • Abolishment of morphology-based taxa and change to binomial species names: 2022 taxonomy update of the ICTV bacterial viruses subcommittee. Reviewed International journal

    Dann Turner, Andrey N Shkoporov, Cédric Lood, Andrew D Millard, Bas E Dutilh, Poliane Alfenas-Zerbini, Leonardo J van Zyl, Ramy K Aziz, Hanna M Oksanen, Minna M Poranen, Andrew M Kropinski, Jakub Barylski, J Rodney Brister, Nina Chanisvili, Rob A Edwards, François Enault, Annika Gillis, Petar Knezevic, Mart Krupovic, Ipek Kurtböke, Alla Kushkina, Rob Lavigne, Susan Lehman, Malgorzata Lobocka, Cristina Moraru, Andrea Moreno Switt, Vera Morozova, Jesca Nakavuma, Alejandro Reyes Muñoz, Jānis Rūmnieks, B L Sarkar, Matthew B Sullivan, Jumpei Uchiyama, Johannes Wittmann, Tong Yigang, Evelien M Adriaenssens

    Archives of virology   168 ( 2 )   74 - 74   2023.1

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    DOI: 10.1007/s00705-022-05694-2

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  • Phylogenic analysis of new viral cluster of large phages with unusual DNA genomes containing uracil in place of thymine in gene-sharing network, using phages S6 and PBS1 and relevant uncultured phages derived from sewage metagenomics Reviewed International journal

    Jumpei Uchiyama, Iyo Takemura-Uchiyama, Kazuyoshi Gotoh, Shin-ichiro Kato, Yoshihiko Sakaguchi, Hironobu Murakami, Tomoki Fukuyama, Mao Kaneki, Osamu Matsushita, Shigenobu Matsuzaki

    Virus Research   319   198881 - 198881   2022.10

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.virusres.2022.198881

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  • Characterization of the oral and fecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony. Reviewed International journal

    Jumpei Uchiyama, Takafumi Osumi, Keijiro Mizukami, Tomoki Fukuyama, Ayaka Shima, Asaka Unno, Iyo Takemura-Uchiyama, Yumi Une, Hironobu Murakami, Masahiro Sakaguchi

    Letters in Applied Microbiology   75 ( 6 )   1607 - 1616   2022.9

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    DOI: 10.1111/lam.13828

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  • Acid-stable capsid structure of Helicobacter pylori bacteriophage KHP30 by single-particle cryoelectron microscopy. Reviewed International journal

    Ryosuke Kamiya, Jumpei Uchiyama, Shigenobu Matsuzaki, Kazuyoshi Murata, Kenji Iwasaki, Naoyuki Miyazaki

    Structure (London, England : 1993)   30 ( 2 )   300 - 312   2021.9

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    DOI: 10.1016/j.str.2021.09.001

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  • Use of Recombinant Endolysin to Improve Accuracy of Group B Streptococcus Tests. Reviewed International journal

    Hidehito Matsui, Jumpei Uchiyama, Masaya Ogata, Tadahiro Nasukawa, Iyo Takemura-Uchiyama, Shin-Ichiro Kato, Hironobu Murakami, Masato Higashide, Hideaki Hanaki

    Microbiology spectrum   9 ( 1 )   e0007721 - 11   2021.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/Spectrum.00077-21

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  • Analyses of propagation processes of Staphylococcus aureus bacteriophages S13' and S25-3 in two different taxonomies by definitive screening design. Reviewed International journal

    Ippei Takeuchi, Tadahiro Nasukawa, Ryosuke Sugimoto, Iyo Takemura-Uchiyama, Hironobu Murakami, Jumpei Uchiyama

    Virus research   298   198406 - 198406   2021.6

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    Authorship:Corresponding author   Language:English   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.virusres.2021.198406

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    Other Link: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04151/

  • Examination of the fecal microbiota in dairy cows infected with bovine leukemia virus. Reviewed International journal

    Jumpei Uchiyama, Hironobu Murakami, Reiichiro Sato, Keijiro Mizukami, Takehito Suzuki, Ayaka Shima, Genki Ishihara, Kazuyuki Sogawa, Masahiro Sakaguchi

    Veterinary microbiology   240   108547 - 108547   2020.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.vetmic.2019.108547

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  • Therapeutic Potential of an Endolysin Derived from Kayvirus S25-3 for Staphylococcal Impetigo. Reviewed International journal

    Ichiro Imanishi, Jumpei Uchiyama, Toshihiro Tsukui, Junzo Hisatsune, Kaori Ide, Shigenobu Matsuzaki, Motoyuki Sugai, Koji Nishifuji

    Viruses   11 ( 9 )   769 - 769   2019.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:{MDPI} {AG}  

    DOI: 10.3390/v11090769

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  • Virus purification by CsCl density gradient using general centrifugation. Reviewed International journal

    Tadahiro Nasukawa, Jumpei Uchiyama, Satoshi Taharaguchi, Sumire Ota, Takako Ujihara, Shigenobu Matsuzaki, Hironobu Murakami, Keijirou Mizukami, Masahiro Sakaguchi

    Archives of virology   162 ( 11 )   3523 - 3528   2017.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00705-017-3513-z

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  • Adsorption of Staphylococcus viruses S13 ' and S24-1 on Staphylococcus aureus strains with different glycosidic linkage patterns of wall teichoic acids Reviewed International journal

    Jumpei Uchiyama, Maya Taniguchi, Kenji Kurokawa, Iyo Takemura-Uchiyama, Takako Ujihara, Hidekatsu Shimakura, Yoshihiko Sakaguchi, Hironobu Murakami, Masahiro Sakaguchi, Shigenobu Matsuzaki

    JOURNAL OF GENERAL VIROLOGY   98 ( 8 )   2171 - 2180   2017.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1099/jgv.0.000865

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  • Intragenus generalized transduction in Staphylococcus spp. by a novel giant phage Reviewed International journal

    Jumpei Uchiyama, Iyo Takemura-Uchiyama, Yoshihiko Sakaguchi, Keiji Gamoh, Shin-ichiro Kato, Masanori Daibata, Takako Ujihara, Naoaki Misawa, Shigenobu Matsuzaki

    ISME JOURNAL   8 ( 9 )   1949 - 1952   2014.9

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    DOI: 10.1038/ismej.2014.29

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  • Experimental phage therapy against lethal lung-derived septicemia caused by Staphylococcus aureus in mice Reviewed International journal

    Iyo Takemura-Uchiyama, Jumpei Uchiyama, Makoto Osanai, Norihito Morimoto, Tadashi Asagiri, Takako Ujihara, Masanori Daibata, Tetsuro Sugiura, Shigenobu Matsuzaki

    Microbes and Infection   16 ( 6 )   512 - 517   2014.6

  • Perspective: The age of the phage Reviewed International journal

    Shigenobu Matsuzaki, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Masanori Daibata

    Nature   509 ( 7498 SUPPL. )   S9 - S9   2014.5

  • Novel Anti-MRSA Peptide from Mangrove-Derived Virgibacillus chiguensis FN33 Supported by Genomics and Molecular Dynamics International journal

    Namfa Sermkaew, Apichart Atipairin, Phetcharat Boonruamkaew, Sucheewin Krobthong, Chanat Aonbangkhen, Jumpei Uchiyama, Yodying Yingchutrakul, Nuttapon Songnaka

    Marine Drugs   23 ( 5 )   2025.5

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    Antimicrobial resistance (AMR) is a global health threat, with methicillin-resistant Staphylococcus aureus (MRSA) being one of the major resistant pathogens. This study reports the isolation of a novel mangrove-derived bacterium, Virgibacillus chiguensis FN33, as identified through genome analysis and the discovery of a new anionic antimicrobial peptide (AMP) exhibiting anti-MRSA activity. The AMP was composed of 23 amino acids, which were elucidated as NH3-Glu-Gly-Gly-Cys-Gly-Val-Asp-Thr-Trp-Gly-Cys-Leu-Thr-Pro-Cys-His-Cys-Asp-Leu-Phe-Cys-Thr-Thr-COOH. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for MRSA were 8 µg/mL and 16 µg/mL, respectively. FN33 AMP induced cell membrane permeabilization, suggesting a membrane-disrupting mechanism. The AMP remained stable at 30-40 °C but lost activity at higher temperatures and following exposure to proteases, surfactants, and extreme pH. All-atom molecular dynamics simulations showed that the AMP adopts a β-sheet structure upon membrane interaction. These findings suggest that Virgibacillus chiguensis FN33 is a promising source of novel antibacterial agents against MRSA, supporting alternative strategies for drug-resistant infections.

    DOI: 10.3390/md23050209

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  • Cross-feeding between beneficial and pathogenic bacteria to utilize eukaryotic host cell-derived sialic acids and bacteriophages shape the pathogen-host interface milieu. International journal

    Darab Ghadimi, Regina Fölster-Holst, Sophia Blömer, Michael Ebsen, Christoph Röcken, Jumpei Uchiyama, Shigenobu Matsuzaki, Wilhelm Bockelmann

    Experimental and molecular pathology   142   104967 - 104967   2025.4

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    Under an inflamed-intestinal milieu, increased free sialic acids are associated with the overgrowth of some pathogenic bacterial strains. Recently, the protective immunomodulatory activity of gut bacteriophages (phages) has also been highlighted. However, the role of phages in triple reciprocal interactions between pathogenic bacteria, beneficial bacteria, and their host cell sialic acids has not been studied so far. We established a sialidase-explicit model in which beneficial and pathogenic bacteria interact through cross-feeding and competition for free sialic acid using a human triple co-culture cell model incorporating colonocytes (T84 cells), monocytes (THP-1 cells), and hepatocytes (Huh7 cells). Triple co-cultured cells were challenged with Gram-positive Bifidobacterium bifidum (B. bifidum) and Gram-negative Pseudomonas aeruginosa PAO1 (P. a PAO1) in the absence or presence of its KPP22 phage in two different cell culture mediums: 1) standard Dulbecco's Modified Eagle Medium (DMEM) and 2) DMEM with 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (DANA). Changes in physiological, functional, and structural health markers of stimulated cocultured cells were evaluated. The concentrations of sialic acid and pro-inflammatory cytokines in the cell culture supernatants were quantified. P. a PAO1 triggered the release of interleukin 6 and 8 (IL-6 and IL-8), accompanied by increased levels of free sialic acid, reduced viability of co-cultured cells, and disrupted the integrity of the cellular monolayer. These disruptive effects were markedly attenuated by KPP22 phage and B. bifidum. In addition to well-documented differences in the structure and composition of the bacterial cell walls of Gram-negative pathogenic bacteria and bifidobacteria, two distinct factors seem to be pivotal in modulating the pathogen-host interface milieu: (i) the presence of phages and (ii) the utilization of free sialic acids secreted from host cells by bifidobacteria.

    DOI: 10.1016/j.yexmp.2025.104967

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  • NovelEscherichia coliPhages Representing a Distinct Genus withinStephanstirmvirinae: Genome and Host Range Characteristics

    Tomoyoshi Kaneko, Jumpei Uchiyama, Toshifumi Osaka, Satoshi Tsuneda

    2025.2

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    DOI: 10.1101/2025.02.05.636633

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  • Disruption of the Enterococcus faecalis–Induced Biofilm on the Intraocular Lens Using Bacteriophages International journal

    Tatsuma Kishimoto, Ken Fukuda, Waka Ishida, Aozora Kuwana, Daisuke Todokoro, Jumpei Uchiyama, Shigenobu Matsuzaki, Kenji Yamashiro

    Translational Vision Science & Technology   13 ( 12 )   25 - 25   2024.12

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    DOI: 10.1167/tvst.13.12.25

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  • Convergence of plant sterols and host eukaryotic cell-derived defensive lipids at the infectious pathogen-host interface. International journal

    Darab Ghadimi, Regina Fölster-Holst, Sophia Blömer, Michael Ebsen, Christoph Röcken, Jumpei Uchiyama, Shigenobu Matsuzaki, Wilhelm Bockelmann

    Biochimie   231   35 - 45   2024.12

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    DOI: 10.1016/j.biochi.2024.12.001

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  • Exploring interplay between bovine milk-derived α-lactalbumin, pathogenic bacteria, and bacteriophages at the molecular interface of inflammation. Reviewed International coauthorship International journal

    Darab Ghadimi, Aysel Şahi N Kaya, Sandra Krüger, Christoph Röcken, Heiner Schäfer, Jumpei Uchiyama, Shigenobu Matsuzaki, Wilhelm Bockelmann

    Comparative immunology, microbiology and infectious diseases   115   102271 - 102271   2024.10

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    DOI: 10.1016/j.cimid.2024.102271

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  • Analysis of the life cycle of Helicobacter pylori bacteriophage KHP40 belonging to the genus Schmidvirus. Reviewed International journal

    Masahiro Iwamoto, Michiko Takahashi, Hiromichi Maeda, Hiroaki Takeuchi, Jumpei Uchiyama, Takako Ujihara, Keizo Nagasaki, Kazuhiro Hanazaki, Satoru Seo, Naoya Kitamura, Tetsuya Yamamoto, Shigenobu Matsuzaki

    FEMS microbiology letters   371   2024.10

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    DOI: 10.1093/femsle/fnae082

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  • Unveiling a New Antimicrobial Peptide with Efficacy against P. aeruginosa and K. pneumoniae from Mangrove-Derived Paenibacillus thiaminolyticus NNS5-6 and Genomic Analysis Reviewed International coauthorship International journal

    Namfa Sermkaew, Apichart Atipairin, Sucheewin Krobthong, Chanat Aonbangkhen, Yodying Yingchutrakul, Jumpei Uchiyama, Nuttapon Songnaka

    Antibiotics   13 ( 9 )   2024.9

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    DOI: 10.3390/antibiotics13090846

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  • Intricate Crosstalk Between Food Allergens, Phages, Bacteria, and Eukaryotic Host Cells of the Gut-skin Axis. Reviewed International coauthorship International journal

    Darab Ghadimi, Regina Fölster-Holst, Sophia Blömer, Michael Ebsen, Christoph Röcken, Jumpei Uchiyama, Shigenobu Matsuzaki, Wilhelm Bockelmann

    The Yale journal of biology and medicine   97 ( 3 )   309 - 324   2024.9

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    DOI: 10.59249/HAXK9033

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  • A Novel Bacitracin-like Peptide from Mangrove-Isolated Bacillus paralicheniformis NNS4-3 against MRSA and Its Genomic Insights Reviewed International journal

    Namfa Sermkaew, Apichart Atipairin, Thamonwan Wanganuttara, Sucheewin Krobthong, Chanat Aonbangkhen, Yodying Yingchutrakul, Jumpei Uchiyama, Nuttapon Songnaka

    Antibiotics   13 ( 8 )   2024.7

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    DOI: 10.3390/antibiotics13080716

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  • Investigation of periodontal disease development and Porphyromonas gulae FimA genotype distribution in small dogs Reviewed International journal

    Junya Yasuda, Hidemi Yasuda, Ryota Nomura, Saaya Matayoshi, Hiroaki Inaba, Enrique Gongora, Naoki Iwashita, So Shirahata, Noriyuki Kaji, Tatsuya Akitomo, Chieko Mitsuhata, Jumpei Uchiyama, Tomoki Fukuyama, Michiyo Matsumoto-Nakano, Kazuhiko Nakano, Masaru Murakami

    Scientific Reports   14 ( 1 )   5360 - 5360   2024.3

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    DOI: 10.1038/s41598-024-55842-8

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  • Highly specific and sensitive detection of bacteria by dark-field light-scattering imaging based on bacteriophage-modified magnetoplasmonic nanoparticles Reviewed

    Masashi Imai, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shigenobu Matsuzaki, Yosuke Niko, Shingo Hadano, Shigeru Watanabe

    Bulletin of the Chemical Society of Japan   97 ( 2 )   2024.2

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    DOI: 10.1093/bulcsj/uoad010

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  • Examination of yield, bacteriolytic activity and cold storage of linker deletion mutants based on endolysin S6_ORF93 derived from Staphylococcus giant bacteriophage S6. International journal

    Sosuke Munetomo, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Thamonwan Wanganuttara, Yumiko Yamamoto, Toshihiro Tsukui, Hideharu Hagiya, Shuji Kanamaru, Hideyuki Kanda, Osamu Matsushita

    PloS one   19 ( 10 )   e0310962   2024

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    DOI: 10.1371/journal.pone.0310962

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  • Exploring the Interplay between Nutrients, Bacteriophages, and Bacterial Lipases in Host- and Bacteria-mediated Pathogenesis. Reviewed International journal

    Darab Ghadimi, Regina Fölster-Holst, Michael Ebsen, Christoph Röcken, Christof Dörfer, Jumpei Uchiyama, Shigenobu Matsuzaki, Wilhelm Bockelmann

    Endocrine, metabolic & immune disorders drug targets   24 ( 8 )   930 - 945   2023.11

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    DOI: 10.2174/0118715303257321231024094904

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  • Anti-methicillin-resistant Staphylococcus aureus and antibiofilm activity of new peptides produced by a Brevibacillus strain Reviewed International journal

    Abiodun Ogunsile, Nuttapon Songnaka, Somchai Sawatdee, Monthon Lertcanawanichakul, Sucheewin Krobthong, Yodying Yingchutrakul, Jumpei Uchiyama, Apichart Atipairin

    PeerJ   11   e16143   2023.10

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    DOI: 10.7717/peerj.16143

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  • Bacteriophage-Conjugated Fluorescent Nanoemulsion as a Novel Optical Probe for Highly Selective Bacterial Detection Reviewed

    Shin-ya Sekida, Takatoshi Chisaka, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shigenobu Matsuzaki, Yosuke Niko, Shingo Hadano, Shigeru Watanabe

    Bulletin of the Chemical Society of Japan   96 ( 11 )   1234 - 1242   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Chemical Society of Japan  

    DOI: 10.1246/bcsj.20230200

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  • Exploratory study of volatile fatty acids and the rumen-and-gut microbiota of dairy cows in a single farm, with respect to subclinical infection with bovine leukemia virus Reviewed

    Takehito Suzuki, Hironobu Murakami, Jumpei Uchiyama, Reiichiro Sato, Iyo Takemura-Uchiyama, Masaya Ogata, Kazuyuki Sogawa, Hiroho Ishida, Apichart Atipairin, Osamu Matsushita, Makoto Nagai

    Annals of Microbiology   73 ( 1 )   2023.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1186/s13213-023-01737-4

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    Other Link: https://link.springer.com/article/10.1186/s13213-023-01737-4/fulltext.html

  • Therapeutic potential of ozone water treatment in alleviating atopic dermatitis symptoms in mouse models: Exploring its bactericidal and direct anti-inflammatory properties. Reviewed International journal

    Mao Kaneki, Chiharu Ohira, Miyu Takahashi, Naoki Iwashita, Yoshiichi Takagi, Masaki Nagane, Jumpei Uchiyama, Tomoki Fukuyama

    International immunopharmacology   124 ( Pt A )   110920 - 110920   2023.9

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    DOI: 10.1016/j.intimp.2023.110920

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  • The Effect of Subacute Oral Folic Acid Treatment on Growth of Porphyromonas gulae in Dogs. Reviewed International journal

    So Shirahata, Yumi Katayama, Mao Kaneki, Jumpei Uchiyama, Tomoki Fukuyama

    Journal of veterinary dentistry   41 ( 4 )   8987564231189650 - 8987564231189650   2023.7

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    DOI: 10.1177/08987564231189650

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  • Antimicrobial resistance and genotyping of Pseudomonas aeruginosa isolated from the ear canals of dogs in Japan Reviewed International journal

    Ahmed Elfadadny, Jumpei Uchiyama, Kazuyoshi Goto, Ichiro Imanishi, Rokaia F. Ragab, Wedad M. Nageeb, Keita Iyori, Yoichi Toyoda, Toshihiro Tsukui, Kaori Ide, Keiko Kawamoto, Koji Nishifuji

    Frontiers in Veterinary Science   10   1074127 - 1074127   2023.7

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    DOI: 10.3389/fvets.2023.1074127

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  • Metataxonomic Analysis of the Uterine Microbiota Associated with Low Fertility in Dairy Cows Using Endometrial Tissues Prior to First Artificial Insemination. Reviewed International journal

    Takuya Yagisawa, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shun Ando, Osamu Ichii, Hironobu Murakami, Osamu Matsushita, Seiji Katagiri

    Microbiology spectrum   11 ( 3 )   e0476422   2023.4

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    DOI: 10.1128/spectrum.04764-22

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  • Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs. Reviewed International journal

    So Shirahata, Naoki Iwashita, Rie Sasaki, Ryota Nomura, Masaru Murakami, Junya Yasuda, Hidemi Yasuda, Kuniyasu Nakajima, Hiroaki Inaba, Michiyo Matsumoto-Nakano, Kazuhiko Nakano, Jumpei Uchiyama, Tomoki Fukuyama

    Frontiers in veterinary science   10   1022838 - 1022838   2023

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  • Oral application of persimmon tannin significantly inhibited the halitosis and pro-inflammatory response in a Porphyromonas gulae dependent periodontal disease in dogs.

    Megu Toyooka, Kaneki Mao, Ohira Chiharu, Uchiyama Jumpei, Fukuyama Tomoki

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   97   2-B-SS12-1   2023

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    Periodontal disease is a serious problem in the veterinary field, as it is reported that more than 80% of dogs over 6 years of age suffer from periodontal disease. Severe periodontal infection is irreversible; therefore, once the supporting tissues are damaged, there is no possibility of recovery. Therefore, preventive dentistry, such as daily tooth-cleaning and dental gel from early life, at the veterinary hospital as well as at home, is quite important. In this study, we focused on persimmon tannin, a polyphenol extracted from persimmon, and examined the bactericidal, anti-halitosis and anti-inflammatory effects in vitro using Porphyromonas gulae (P. gulae), which is a major contributor to the progression of periodontal disease in dogs. Clinical study in 20 dogs with severe periodontal disease was also conducted by daily oral application of 1% persimmon tannin gel. Whereas persimmon tannins did not alter the growth of P. gulae, significant inhibition of CH3SH production by P. gulae, and significant inhibition of IL-6, IL-1β and TNFα production by mouse macrophage cell line infected with P. gulae were observed in persimmon tannin treated group. In vitro anti-halitosis, and anti-inflammatory effects of persimmon tannin were confirmed by clinical experiments in dogs with P. gulae-associated periodontal diseases, and one-month oral treatment with 1% persimmon tannin contained dental gel significantly reduced halitosis and P. gulae activity. Our findings suggest that oral treatment with persimmon tannin can be a preventive option for periodontal disease in dogs.

    DOI: 10.1254/jpssuppl.97.0_2-b-ss12-1

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  • Guest edited collection serological study of SARS-CoV-2 antibodies in japanese cats using protein-A/G-based ELISA. Reviewed International journal

    Ichiro Imanishi, Ryota Asahina, Shunji Hayashi, Jumpei Uchiyama, Masaharu Hisasue, Masahiro Yamasaki, Yoshiteru Murata, Shigeru Morikawa, Tetsuya Mizutani, Masahiro Sakaguchi

    BMC veterinary research   18 ( 1 )   443 - 443   2022.12

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    DOI: 10.1186/s12917-022-03527-7

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  • Antibiotic-resistant status and pathogenic clonal complex of canine Streptococcus canis-associated deep pyoderma. Reviewed International journal

    Ichiro Imanishi, Keita Iyori, Akira Také, Ryota Asahina, Manami Tsunoi, Ryuji Hirano, Jumpei Uchiyama, Yoichi Toyoda, Yoshihiko Sakaguchi, Shunji Hayashi

    BMC veterinary research   18 ( 1 )   395 - 395   2022.11

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    DOI: 10.1186/s12917-022-03482-3

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  • Effects of Inherent Lactic Acid Bacteria on Inhibition of Angiotensin I-Converting Enzyme and Antioxidant Activities in Dry-Cured Meat Products Reviewed International journal

    Masaya Ogata, Jumpei Uchiyama, Abdulatef M. Ahhmed, Seiichi Sakuraoka, Satoshi Taharaguchi, Ryoichi Sakata, Wataru Mizunoya, Shiro Takeda

    Foods   11 ( 14 )   2123 - 2123   2022.7

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    DOI: 10.3390/foods11142123

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  • Screening of bacterial DNA in bile sampled from healthy dogs and dogs suffering from liver- or gallbladder-associated disease. Reviewed

    Sakurako Neo, Iyo Takemura-Uchiyama, Jumpei Uchiyama, Hironobu Murakami, Ayaka Shima, Hideki Kayanuma, Taiki Yokoyama, Satoshi Takagi, Eiichi Kanai, Masaharu Hisasue

    The Journal of veterinary medical science   84 ( 7 )   1019 - 1022   2022.5

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    DOI: 10.1292/jvms.22-0090

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  • Intracameral Bacteriophage Injection as Postoperative Prophylaxis for Enterococcus faecalis-Induced Endophthalmitis After Cataract Surgery in Rabbits. Reviewed International journal

    Tatsuma Kishimoto, Waka Ishida, Isana Nakajima, Takako Ujihara, Takashi Suzuki, Jumpei Uchiyama, Shigenobu Matsuzaki, Ken Fukuda

    Translational vision science & technology   11 ( 4 )   2 - 2   2022.4

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    DOI: 10.1167/tvst.11.4.2

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  • Heterogeneous IgE reactivities to Staphylococcus pseudintermedius strains in dogs with atopic dermatitis, and the identification of DM13-domain-containing protein as a bacterial IgE-reactive molecule. Reviewed International journal

    Iyo Takemura-Uchiyama, Hiroki Tsurui, Hidekatsu Shimakura, Tadahiro Nasukawa, Ichiro Imanishi, Jumpei Uchiyama, Tomoki Fukuyama, Shuji Sakamoto, Keiko Morisawa, Masato Fujimura, Hironobu Murakami, Shuji Kanamaru, Kenji Kurokawa, Keiko Kawamoto, Keita Iyori, Masahiro Sakaguchi

    FEMS microbiology letters   369 ( 1 )   2022.2

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    DOI: 10.1093/femsle/fnac019

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  • Anaphylaxis after vaccination for cats in Japan. Reviewed

    Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi

    The Journal of veterinary medical science   84 ( 1 )   149 - 152   2021.11

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    DOI: 10.1292/jvms.21-0437

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  • Bacterial Viruses Subcommittee and Archaeal Viruses Subcommittee of the ICTV: update of taxonomy changes in 2021. Reviewed International journal

    Mart Krupovic, Dann Turner, Vera Morozova, Mike Dyall-Smith, Hanna M Oksanen, Rob Edwards, Bas E Dutilh, Susan M Lehman, Alejandro Reyes, Diana P Baquero, Matthew B Sullivan, Jumpei Uchiyama, Jesca Nakavuma, Jakub Barylski, Mark J Young, Shishen Du, Poliane Alfenas-Zerbini, Alla Kushkina, Andrew M Kropinski, Ipek Kurtböke, J Rodney Brister, Cédric Lood, B L Sarkar, Tong Yigang, Ying Liu, Li Huang, Johannes Wittmann, Nina Chanishvili, Leonardo J van Zyl, Janis Rumnieks, Tomohiro Mochizuki, Matti Jalasvuori, Ramy K Aziz, Małgorzata Łobocka, Kenneth M Stedman, Andrey N Shkoporov, Annika Gillis, Xu Peng, François Enault, Petar Knezevic, Rob Lavigne, Sung-Keun Rhee, Virginija Cvirkaite-Krupovic, Cristina Moraru, Andrea I Moreno Switt, Minna M Poranen, Andrew Millard, David Prangishvili, Evelien M Adriaenssens

    Archives of virology   166 ( 11 )   3239 - 3244   2021.8

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    DOI: 10.1007/s00705-021-05205-9

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  • New dot-blot method for evaluating the effect of inactivators on mite and Japanese cedar pollen allergens. Reviewed International journal

    Megumi Yoshida, Keijiro Mizukami, Keigo Kurata, Tadahiro Nasukawa, Jumpei Uchiyama, Masahiro Sakaguchi

    Bioscience, biotechnology, and biochemistry   85 ( 10 )   2089 - 2092   2021.8

  • IgE reactivity to milk components in dogs with cutaneous adverse food reactions. Reviewed

    Hidekatsu Shimakura, Tadahiro Nasukawa, Jumpei Uchiyama, Ryosuke Sugimoto, Ichiro Imanishi, Sumire Oota, Keijiro Mizukami, Masato Fujimura, Masahiro Sakaguchi

    The Journal of veterinary medical science   83 ( 10 )   1509 - 1512   2021.8

  • Anaphylaxis after rabies vaccination for dogs in Japan. Reviewed

    Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi

    The Journal of veterinary medical science   83 ( 8 )   1202 - 1205   2021.8

  • African pygmy hedgehog adenovirus: Virus replication, virus-induced cytopathogenesis and activation of mitogen-activated protein kinase signaling pathways in infected MDCK cells. Reviewed International journal

    Rongduo Wen, Hideharu Ochiai, Jumpei Uchiyama, Nanako Osawa, Mami Oba, Yukie Katayama, Kaixin Li, Tsutomu Omatsu, Kenichi Tamukai, Kaoru Suzuki, Hiroo Madarame, Shinji Makino, Tetsuya Mizutani

    Research in veterinary science   139   152 - 158   2021.7

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    DOI: 10.1016/j.rvsc.2021.07.016

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  • Specific antiviral effect of violaceoid E on bovine leukemia virus. Reviewed International journal

    Hironobu Murakami, Makoto Murakami-Kawai, Shinji Kamisuki, Shibasaki Hisanobu, Yukine Tsurukawa, Jumpei Uchiyama, Masahiro Sakaguchi, Kenji Tsukamoto

    Virology   562   1 - 8   2021.7

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    DOI: 10.1016/j.virol.2021.06.010

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  • In Vitro and In Vivo Evaluation of Three Newly Isolated Bacteriophage Candidates, phiEF7H, phiEF14H1, phiEF19G, for Treatment of Enterococcus faecalis Endophthalmitis. Reviewed International journal

    Tatsuma Kishimoto, Waka Ishida, Tadahiro Nasukawa, Takako Ujihara, Isana Nakajima, Takashi Suzuki, Jumpei Uchiyama, Daisuke Todokoro, Masanori Daibata, Atsuki Fukushima, Shigenobu Matsuzaki, Ken Fukuda

    Microorganisms   9 ( 2 )   1 - 12   2021.1

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    DOI: 10.3390/microorganisms9020212

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  • Purification of membrane vesicles from Gram-positive bacteria using flow cytometry, after iodixanol density-gradient ultracentrifugation Reviewed International journal

    Tadahiro Nasukawa, Ryosuke Sugimoto, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Hironobu Murakami, Ken Fukuda, Shigenobu Matsuzaki, Masahiro Sakaguchi

    Research in Microbiology   172 ( 1 )   103792 - 103792   2021.1

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  • Functionality of liquid smoke as an antimicrobial in cooked meat products: liquid smoke suppresses spoilage-related lactic acid bacteria Reviewed

    Shiro TAKEDA, Jumpei UCHIYAMA, Kazutoshi SUGITA, Hirofumi ENOMOTO, Abdulatef M AHHMED, Yuki KINOSHITA, Wataru MIZUNOYA, Yoshitaka ARIMA, Ryoichi SAKATA

    Food Science and Technology Research   27 ( 5 )   759 - 768   2021

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    DOI: 10.3136/fstr.27.759

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  • Analysis of a plasmid encoding botulinum neurotoxin type G gene in Clostridium argentinense. Reviewed International journal

    Yoshihiko Sakaguchi, Jumpei Uchiyama, Akira Také, Kazuyoshi Gotoh, Masakiyo Sakaguchi, Tomonori Suzuki, Yumiko Yamamoto, Koji Hosomi, Tomoko Kohda, Masafumi Mukamoto, Shunji Kozaki, Shunji Hayashi, Keiji Oguma

    Anaerobe   66   102281 - 102281   2020.12

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    DOI: 10.1016/j.anaerobe.2020.102281

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  • IgE reactivity to fish allergens from Pacific cod (Gadus macrocephalus) in atopic dogs. Reviewed International journal

    Ichiro Imanishi, Jumpei Uchiyama, Keijiro Mizukami, Junichi Kamiie, Keigo Kurata, Keita Iyori, Masato Fujimura, Kuniyoshi Shimakura, Koji Nishifuji, Masahiro Sakaguchi

    BMC veterinary research   16 ( 1 )   341 - 341   2020.9

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    DOI: 10.1186/s12917-020-02559-1

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  • Development of multipurpose recombinant reporter bovine leukemia virus. Reviewed International journal

    Hironobu Murakami, Yusuke Yajima, Fumiaki Sato, Shinji Kamisuki, Satoshi Taharaguchi, Ken Onda, Sanggun Roh, Jumpei Uchiyama, Masahiro Sakaguchi, Kenji Tsukamoto

    Virology   548   226 - 235   2020.9

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    DOI: 10.1016/j.virol.2020.07.011

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  • IgE sensitivity to Malassezia pachydermatis and mite allergens in dogs with atopic dermatitis. Reviewed International journal

    Hironobu Ishimaru, Noriaki Okamoto, Masato Fujimura, Kazuki Miyaji, Hidekatsu Shimakura, Yukari Takase, Keijiro Mizukami, Jumpei Uchiyama, Douglas J DeBoer, Masahiro Sakaguchi

    Veterinary immunology and immunopathology   226   110070 - 110070   2020.8

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    DOI: 10.1016/j.vetimm.2020.110070

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  • Taxonomy of prokaryotic viruses: 2018-2019 update from the ICTV Bacterial and Archaeal Viruses Subcommittee. Reviewed International journal

    Evelien M Adriaenssens, Matthew B Sullivan, Petar Knezevic, Leonardo J van Zyl, B L Sarkar, Bas E Dutilh, Poliane Alfenas-Zerbini, Małgorzata Łobocka, Yigang Tong, James Rodney Brister, Andrea I Moreno Switt, Jochen Klumpp, Ramy Karam Aziz, Jakub Barylski, Jumpei Uchiyama, Rob A Edwards, Andrew M Kropinski, Nicola K Petty, Martha R J Clokie, Alla I Kushkina, Vera V Morozova, Siobain Duffy, Annika Gillis, Janis Rumnieks, İpek Kurtböke, Nina Chanishvili, Lawrence Goodridge, Johannes Wittmann, Rob Lavigne, Ho Bin Jang, David Prangishvili, Francois Enault, Dann Turner, Minna M Poranen, Hanna M Oksanen, Mart Krupovic

    Archives of virology   165 ( 5 )   1253 - 1260   2020.5

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    DOI: 10.1007/s00705-020-04577-8

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  • Therapeutic Effects of Intravitreously Administered Bacteriophage in a Mouse Model of Endophthalmitis Caused by Vancomycin-Sensitive or -Resistant Enterococcus faecalis. Reviewed International journal

    Tatsuma Kishimoto, Waka Ishida, Ken Fukuda, Isana Nakajima, Takashi Suzuki, Jumpei Uchiyama, Shigenobu Matsuzaki, Daisuke Todokoro, Masanori Daibata, Atsuki Fukushima

    Antimicrobial agents and chemotherapy   63 ( 11 )   2019.11

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    DOI: 10.1128/AAC.01088-19

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  • Novel neuroprotective hydroquinones with a vinyl alkyne from the fungus, Pestalotiopsis microspora. Reviewed

    Kazuki Kanno, Yukine Tsurukawa, Shinji Kamisuki, Hisanobu Shibasaki, Keita Iguchi, Hironobu Murakami, Jumpei Uchiyama, Kouji Kuramochi

    The Journal of antibiotics   72 ( 11 )   793 - 799   2019.11

  • A point mutation to the long terminal repeat of bovine leukemia virus related to viral productivity and transmissibility. Reviewed International journal

    Hironobu Murakami, Haruna Todaka, Jumpei Uchiyama, Reiichiro Sato, Kazuyuki Sogawa, Masahiro Sakaguchi, Kenji Tsukamoto

    Virology   537   45 - 52   2019.11

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    DOI: 10.1016/j.virol.2019.08.015

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  • Phage pharmacokinetics: Relationship with administration route Reviewed

    Shigenobu Matsuzaki, Jumpei Uchiyama

    Phage Therapy: A Practical Approach   43 - 57   2019.10

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    DOI: 10.1007/978-3-030-26736-0_2

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  • Complete Genome Sequence of an Adenovirus-1 Isolate from an African Pygmy Hedgehog (Atelerix albiventris) Exhibiting Respiratory Symptoms in Japan. Reviewed International journal

    Hiroo Madarame, Jumpei Uchiyama, Kenichi Tamukai, Yukie Katayama, Nanako Osawa, Kaoru Suzuki, Tetsuya Mizutani, Hideharu Ochiai

    Microbiology resource announcements   8 ( 40 )   2019.10

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    DOI: 10.1128/MRA.00695-19

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  • Dark-Field Microscopic Detection of Bacteria using Bacteriophage-Immobilized SiO2@AuNP Core-Shell Nanoparticles. Reviewed International journal

    Masashi Imai, Kouhei Mine, Haruna Tomonari, Jumpei Uchiyama, Shigenobu Matuzaki, Yosuke Niko, Shingo Hadano, Shigeru Watanabe

    Analytical chemistry   91 ( 19 )   12352 - 12357   2019.10

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    DOI: 10.1021/acs.analchem.9b02715

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  • Therapeutic Effects of Intravitreously Administered Bacteriophage in a Mouse Model of Endophthalmitis Caused by Vancomycin-Sensitive or -Resistant Enterococcus faecalis Reviewed

    Jumpei Uchiyama

    Antimicrobial Agents and Chemotherapy   2019.8

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    <jats:p>Endophthalmitis due to infection with <jats:italic>Enterococcus</jats:italic> spp. progresses rapidly and often results in substantial and irreversible vision loss. Given that the frequency of this condition caused by vancomycin-resistant <jats:italic>Enterococcus faecalis</jats:italic> has been increasing, the development of novel therapeutics is urgently required. We have now demonstrated the therapeutic potential of bacteriophage ΦEF24C-P2 in a mouse model of endophthalmitis caused by vancomycin-sensitive (EF24) or vancomycin-resistant (VRE2) strains of <jats:italic>E. faecalis</jats:italic>. Phage ΦEF24C-P2 induced rapid and pronounced bacterial lysis in turbidity reduction assays with EF24, VRE2, and clinical isolates derived from patients with <jats:italic>E. faecalis</jats:italic>–related postoperative endophthalmitis. Endophthalmitis was induced in mice by injection of EF24 or VRE2 (1 × 10<jats:sup>4</jats:sup> cells) into the vitreous. The number of viable bacteria in the eye increased to &gt;1 × 10<jats:sup>7</jats:sup> colony forming units and neutrophil infiltration into the eye was detected as an increase in myeloperoxidase activity at 24 h after infection. A clinical score based on loss of visibility of the fundus as well as the number of viable bacteria and the level of myeloperoxidase activity in the eye were all significantly decreased by intravitreous injection of ΦEF24C-P2 6 h after injection of EF24 or VRE2. Whereas histopathologic analysis revealed massive infiltration of inflammatory cells and retinal detachment in vehicle-treated eyes, the number of these cells was greatly reduced and retinal structural integrity was preserved in phage-treated eyes. Our results thus suggest that intravitreous phage therapy is a potential treatment for endophthalmitis caused by vancomycin-sensitive or -resistant strains of <jats:italic>E. faecalis.</jats:italic></jats:p>

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  • Novel neuroprotective hydroquinones with a vinyl alkyne from the fungus, Pestalotiopsis microspora Reviewed

    Jumpei Uchiyama

    The Journal of Antibiotics   2019.7

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    DOI: 10.1038/s41429-019-0213-9

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  • Therapeutic effects of intravitreous bacteriophage on Enterococcus faecalis endophthalmitis in mice Reviewed

    Fukuda Ken, Kishimoto Tatsuma, Ishida Waka, Suzuki Takashi, Uchiyama Jumpei, Matsuzaki Shigenobu, Daibata Masanori, Fukushima Atsuki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   60 ( 9 )   2019.7

  • Age-related analysis of the gut microbiome in a purebred dog colony Reviewed International journal

    Keijiro Mizukami, Jumpei Uchiyama, Hirotaka Igarashi, Hironobu Murakami, Takafumi Osumi, Ayaka Shima, Genki Ishiahra, Tadahiro Nasukawa, Yumi Une, Masahiro Sakaguchi

    FEMS Microbiology Letters   366 ( 8 )   2019.4

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    DOI: 10.1093/femsle/fnz095

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  • IgE reactivity to Pacific cod (Gadus macrocephalus) fish allergens in dogs with canine atopic dermatitis Reviewed

    Imanishi Ichiro, Uchiyama Jumpei, Matsuda Takako, Mizukami Keijiro, Shimakura Hidekatsu, Nasukawa Tadahiro, Kamiie Junichi, Kurata Keigo, Fujimura Masato, Shimakura Kuniyoshi, Nishifuji Koji, Sakaguchi Masahiro

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   143 ( 2 )   AB68 - AB68   2019.2

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  • Use of a Silkworm Larva Model in Phage Therapy Experiments Reviewed International journal

    Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shigenobu Matsuzaki

    Methods in Molecular Biology   1898   173 - 181   2019

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    DOI: 10.1007/978-1-4939-8940-9_14

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    Other Link: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07127/

  • Potential Application of Bacteriophages in Enrichment Culture for Improved Prenatal Streptococcus agalactiae Screening Reviewed International journal

    Jumpei Uchiyama, Hidehito Matsui, Hironobu Murakami, Shin-ichiro Kato, Naoki Watanabe, Tadahiro Nasukawa, Keijiro Mizukami, Masaya Ogata, Masahiro Sakaguchi, Shigenobu Matsuzaki, Hideaki Hanaki

    VIRUSES-BASEL   10 ( 10 )   2018.10

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    DOI: 10.3390/v10100552

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  • Piperacillin and ceftazidime produce the strongest synergistic phage-antibiotic effect in Pseudomonas aeruginosa Reviewed International journal

    Jumpei Uchiyama, Ryu Shigehisa, Tadahiro Nasukawa, Keijiro Mizukami, Iyo Takemura-Uchiyama, Takako Ujihara, Hironobu Murakami, Ichiro Imanishi, Koji Nishifuji, Masahiro Sakaguchi, Shigenobu Matsuzaki

    ARCHIVES OF VIROLOGY   163 ( 7 )   1941 - 1948   2018.7

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    DOI: 10.1007/s00705-018-3811-0

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  • Recovery of mycobacteriophages from archival stocks stored for approximately 50 years in Japan Reviewed International journal

    Takako Ujihara, Jumpei Uchiyama, Tadahiro Nasukawa, Hiroki Ando, Hironobu Murakami, Naoya Ohara, Midori Ogawa, Toshio Yamazaki, Masanori Daibata, Masahiro Sakaguchi, Shigenobu Matsuzaki

    ARCHIVES OF VIROLOGY   163 ( 7 )   1915 - 1919   2018.7

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    DOI: 10.1007/s00705-018-3788-8

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  • Variations in the viral genome and biological properties of bovine leukemia virus wild-type strains

    Jumpei Uchiyama

    Virus Research   253   103 - 111   2018.7

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    DOI: 10.1016/j.virusres.2018.06.005

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  • Polymorphisms in the Helicobacter pylori NY43 strain and its prophage-cured derivatives Reviewed International journal

    Jumpei Uchiyama

    Microbiology   164 ( 6 )   877 - 882   2018.6

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    DOI: 10.1099/mic.0.000665

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  • Genome Sequences of 12 Mycobacteriophages Recovered from Archival Stocks in Japan Reviewed International journal

    Jumpei Uchiyama, Keijiro Mizukami, Koji Yahara, Shin-ichiro Kato, Hironobu Murakami, Tadahiro Nasukawa, Naoya Ohara, Midori Ogawa, Toshio Yamazaki, Shigenobu Matsuzaki, Masahiro Sakaguchi

    MICROBIOLOGY RESOURCE ANNOUNCEMENTS   6 ( 25 )   2018.6

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    DOI: 10.1128/genomeA.00472-18

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  • Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee Reviewed International journal

    Evelien M. Adriaenssens, Johannes Wittmann, Jens H. Kuhn, Dann Turner, Matthew B. Sullivan, Bas E. Dutilh, Ho Bin Jang, Leonardo J. van Zyl, Jochen Klumpp, Malgorzata Lobocka, Andrea I. Moreno Switt, Janis Rumnieks, Robert A. Edwards, Jumpei Uchiyama, Poliane Alfenas-Zerbini, Nicola K. Petty, Andrew M. Kropinski, Jakub Barylski, Annika Gillis, Martha R.C. Clokie, David Prangishvili, Rob Lavigne, Ramy Karam Aziz, Siobain Duffy, Mart Krupovic, Minna M. Poranen, Petar Knezevic, Francois Enault, Yigang Tong, Hanna M. Oksanen, J. Rodney Brister

    Archives of Virology   163 ( 4 )   1125 - 1129   2018.4

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    DOI: 10.1007/s00705-018-3723-z

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  • Isolation of Bacteriophages for Fastidious Bacteria Reviewed International journal

    Matsuzaki, Shigenobu, Uchiyama, Jumpei, Takemura-Uchiyama, Iyo, Ujihara, Takako, Daibata, Masanori

    Bacteriophage Therapy   1693   3 - 10   2018

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    DOI: 10.1007/978-1-4939-7395-8_1

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  • Development of a New Punch Head Shape to Replicate Scale-Up Issues on a Laboratory Tablet Press III: Replicating Sticking Phenomenon Using the SAS Punch and Evaluation by Checking the Tablet Surface Using 3-D Laser Scanning Microscope

    Ito, M., Aoki, S., Uchiyama, J., Yamato, K.

    Journal of Pharmaceutical Sciences   107 ( 8 )   2018

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    DOI: 10.1016/j.xphs.2018.04.012

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  • Bovine leukemia virus G4 enhances virus production. Reviewed International journal

    Hironobu Murakami, Shotaro Asano, Jumpei Uchiyama, Reiichiro Sato, Masahiro Sakaguchi, Kenji Tsukamoto

    Virus research   238   213 - 217   2017.6

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    DOI: 10.1016/j.virusres.2017.07.005

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  • Bovine leukemia virus G4 enhances virus production Reviewed

    Hironobu Murakami, Shotaro Asano, Jumpei Uchiyama, Reiichiro Sato, Masahiro Sakaguchi, Kenji Tsukamoto

    Virus Research   238   213 - 217   2017.6

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    DOI: 10.1016/j.virusres.2017.07.005

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  • Inefficient viral replication of bovine leukemia virus induced by spontaneous deletion mutation in the G4 gene Reviewed International journal

    Hironobu Murakami, Jumpei Uchiyama, Sae Nikaido, Reiichiro Sato, Masahiro Sakaguchi, Kenji Tsukamoto

    Journal of General Virology   97 ( 10 )   2753 - 2762   2016.10

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    DOI: 10.1099/jgv.0.000583

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  • IgE reactivity to hen egg white allergens in dogs with cutaneous adverse food reactions Reviewed International journal

    Hidekatsu Shimakura, Jumpei Uchiyama, Taku Saito, Kazuki Miyaji, Masato Fujimura, Kenichi Masuda, Noriaki Okamoto, Douglas J. DeBoer, Masahiro Sakaguchi

    Veterinary Immunology and Immunopathology   177   52 - 57   2016.9

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    DOI: 10.1016/j.vetimm.2016.06.003

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  • Analyses of Short-Term Antagonistic Evolution of Pseudomonas aeruginosa Strain PAO1 and Phage KPP22 (Myoviridae Family, PB1-Like Virus Genus) Reviewed International journal

    Jumpei Uchiyama, Masato Suzuki, Koji Nishifuji, Shin-ichiro Kato, Reina Miyata, Tadahiro Nasukawa, Kotoe Yamaguchi, Iyo Takemura-Uchiyama, Takako Ujihara, Hidekatsu Shimakura, Hironobu Murakami, Noriaki Okamoto, Yoshihiko Sakaguchi, Keigo Shibayama, Masahiro Sakaguchi, Shigenobu Matsuzaki

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY   82 ( 15 )   4482 - 4491   2016.8

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    DOI: 10.1128/AEM.00090-16

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  • Screening of KHP30-like prophages among Japanese Helicobacter pylori strains, and genetic analysis of a defective KHP30-like prophage sequence integrated in the genome of the H. pylori strain NY40 Reviewed International journal

    Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shin-ichiro Kato, Hiroaki Takeuchi, Yoshihiko Sakaguchi, Takako Ujihara, Masanori Daibata, Hidekatsu Shimakura, Noriaki Okamoto, Masahiro Sakaguchi, Shigenobu Matsuzaki

    FEMS MICROBIOLOGY LETTERS   363 ( 16 )   2016.8

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    DOI: 10.1093/femsle/fnw157

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  • Characterization of Pseudomonas aeruginosa phage KPP21 belonging to family Podoviridae genus N4-like viruses isolated in Japan International journal

    Ryu Shigehisa, Jumpei Uchiyama, Shin ichiro Kato, Iyo Takemura-Uchiyama, Kotoe Yamaguchi, Reina Miyata, Takako Ujihara, Yoshihiko Sakaguchi, Noriaki Okamoto, Hidekatsu Shimakura, Masanori Daibata, Masahiro Sakaguchi, Shigenobu Matsuzaki

    Microbiology and Immunology   60 ( 1 )   64 - 67   2016.1

  • Characterization of a novel Pseudomonas aeruginosa bacteriophage, KPP25, of the family Podoviridae Reviewed International journal

    Reina Miyata, Kotoe Yamaguchi, Jumpei Uchiyama, Ryu Shigehisa, Iyo Takemura-Uchiyama, Shin ichiro Kato, Takako Ujihara, Yoshihiko Sakaguchi, Masanori Daibata, Shigenobu Matsuzaki

    Virus Research   189   43 - 46   2014.8

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    DOI: 10.1016/j.virusres.2014.04.019

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  • In silico analysis of AHJD-like viruses, Staphylococcus aureus phages S24-1 and S13 ', and study of phage S24-1 adsorption Reviewed International journal

    Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shin-ichiro Kato, Miho Sato, Takako Ujihara, Hidehito Matsui, Hideaki Hanaki, Masanori Daibata, Shigenobu Matsuzaki

    MICROBIOLOGYOPEN   3 ( 2 )   257 - 270   2014.4

  • Phage Therapy: Experiments Using Animal Infection Models Reviewed

    Matsuzaki, Shigenobu, Uchiyama, Jumpei, Takemura-Uchiyama, Iyo, Daibata, Masanori

    Phage Therapy   237 - 237   2014

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  • Genome analysis of Pseudomonas aeruginosa bacteriophage KPP23, belonging to the family Siphoviridae Reviewed International journal

    Kotoe Yamaguchi, Reina Miyata, Ryu Shigehisa, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shin Ichiro Kato, Takako Ujihara, Yoshihiko Sakaguchi, Masanori Daibata, Shigenobu Matsuzaki

    Genome Announcements   2 ( 3 )   e00233 - 14   2014

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    DOI: 10.1128/genomeA.00233-14

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  • Draft genome sequence of Clostridium botulinum type B strain Osaka05, isolated from an infant patient with botulism in Japan Reviewed International journal

    Yoshihiko Sakaguchi, Koji Hosomi, Jumpei Uchiyama, Yoshitoshi Ogura, Kaoru Umeda, Masakiyo Sakaguchi, Tomoko Kohda, Masafumi Mukamoto, Naoaki Misawa, Shigenobu Matsuzaki, Tetsuya Hayashi, Shunji Kozaki

    Genome Announcements   2 ( 1 )   2014

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    DOI: 10.1128/genomeA.e01010-13

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  • Evaluating efficacy of bacteriophage therapy against Staphylococcus aureus infections using a silkworm larval infection model International journal

    Iyo Takemura-Uchiyama, Jumpei Uchiyama, Shin ichiro Kato, Tetsuyoshi Inoue, Takako Ujihara, Naoya Ohara, Masanori Daibata, Shigenobu Matsuzaki

    FEMS Microbiology Letters   347 ( 1 )   52 - 60   2013.10

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    DOI: 10.1111/1574-6968.12220

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  • Synergistic bacteriolysis by bacteriophage φeF24C endolysin ORF9 and lantibiotic nisin and its application to pulsed-field gel electrophoretic analysis of Enterococcus faecalis Reviewed

    Iyo Takemura-Uchiyama, Jumpei Uchiyama, Miho Satoh, Takako Ujihara, Masanori Daibata, Shigenobu Matsuzaki

    Annals of Microbiology   63 ( 3 )   1209 - 1211   2013.9

  • Pseudomonas aeruginosa Keratitis in Mice: Effects of Topical Bacteriophage KPP12 Administration Reviewed

    Ken Fukuda, Waka Ishida, Jumpei Uchiyama, Mohammad Rashel, Shin ichiro Kato, Tamae Morita, Asako Muraoka, Tamaki Sumi, Shigenobu Matsuzaki, Masanori Daibata, Atsuki Fukushima

    PLoS ONE   7 ( 10 )   e47742   2012.10

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    DOI: 10.1371/journal.pone.0047742

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  • Complete Genome Sequences of Two Helicobacter pylori Bacteriophages Isolated from Japanese Patients Reviewed

    Jumpei Uchiyama, Hiroaki Takeuchi, Shin-ichiro Kato, Iyo Takemura-Uchiyama, Takako Ujihara, Masanori Daibata, Shigenobu Matsuzaki

    JOURNAL OF VIROLOGY   86 ( 20 )   11400 - 11401   2012.10

  • Analysis of deoxynucleosides in bacteriophages phi EF24C and K and the frequency of a specific restriction site in the genomes of members of the bacteriophage subfamily Spounavirinae Reviewed

    Jumpei Uchiyama, Yusuke Maeda, Iyo Takemura, Keiji Gamoh, Shigenobu Matsuzaki, Masanori Daibata

    ARCHIVES OF VIROLOGY   157 ( 8 )   1587 - 1592   2012.8

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    DOI: 10.1007/s00705-012-1324-9

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  • Therapeutic Effects of Topical Bacteriophage KPP12 Administration on Pseudomonas aeruginosa Keratitis in Mice Reviewed

    Fukuda, Ken, Ishida, Waka, Uchiyama, Jumpei, Morita, Tamae, Harada, Yosuke, Sumi, Tamaki, Matsuzaki, Shigenobu, Daibata, Masanori, Fukushima, Atsuki

    Investigative Ophthalmology & Visual Science   53 ( 14 )   6201 - 6201   2012

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  • Urothelial/lamina propria spontaneous activity and the role of M3 muscarinic receptors in mediating rate responses to stretch and carbachol Reviewed

    Christian Moro, Jumpei Uchiyama, Russ Chess-Williams

    Urology   78 ( 6 )   1442.e9 - 1442.e15   2011.12

  • Improved adsorption of an enterococcus faecalis bacteriophage φEF24C with a spontaneous point mutation Reviewed

    Jumpei Uchiyama, Iyo Takemura, Miho Satoh, Shin ichiro Kato, Takako Ujihara, Kazue Akechi, Shigenobu Matsuzaki, Masanori Daibata

    PLoS ONE   6 ( 10 )   e26648   2011.10

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    DOI: 10.1371/journal.pone.0026648

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  • Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma Reviewed

    Masanao Murakami, Masayuki Imajoh, Takuya Ikawa, Hideki Nakajima, Mikio Kamioka, Yuiko Nemoto, Takako Ujihara, Jumpei Uchiyama, Shigenobu Matsuzaki, Shigetoshi Sano, Masanori Daibata

    Journal of Clinical Virology   50 ( 1 )   37 - 41   2011.1

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    DOI: 10.1016/j.jcv.2010.09.013

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  • Characterization of lytic enzyme open reading frame 9 (ORF9) derived from Enterococcus faecalis bacteriophage $φ$EF24C Reviewed

    Uchiyama, Jumpei, Takemura, Iyo, Hayashi, Ikue, Matsuzaki, Shigenobu, Satoh, Miho, Ujihara, Takako, Murakami, Masanao, Imajoh, Masayuki, Sugai, Motoyuki, Daibata, Masanori

    Applied and environmental microbiology   77 ( 2 )   580 - 585   2011

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    DOI: 10.1128/AEM.01540-10

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  • Isolation and characterization of a novel Staphylococcus aureus bacteriophage, φMR25, and its therapeutic potential Reviewed

    Hiroshi Hoshiba, Jumpei Uchiyama, Shin ichiro Kato, Takako Ujihara, Asako Muraoka, Masanori Daibata, Hiroshi Wakiguchi, Shigenobu Matsuzaki

    Archives of Virology   155 ( 4 )   545 - 552   2010.4

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    DOI: 10.1007/s00705-010-0623-2

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  • Morphological and genetic analysis of three bacteriophages of Serratia marcescens isolated from environmental water: Research Letter Reviewed

    Kenshi Matsushita, Jumpei Uchiyama, Shin Ichiro Kato, Takako Ujihara, Hiroshi Hoshiba, Shigeyoshi Sugihara, Asako Muraoka, Hiroshi Wakiguchi, Shigenobu Matsuzaki

    FEMS Microbiology Letters   291 ( 2 )   201 - 208   2009.2

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  • Characteristics of a novel Pseudomonas aeruginosa bacteriophage, PAJU2, which is genetically related to bacteriophage D3 Reviewed

    Jumpei Uchiyama, Mohammad Rashel, Tetsuya Matsumoto, Yoshinobu Sumiyama, Hiroshi Wakiguchi, Shigenobu Matsuzaki

    Virus Research   139 ( 1 )   131 - 134   2009.1

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    DOI: 10.1016/j.virusres.2008.10.005

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  • Tail-associated structural protein gp61 of Staphylococcus aureus phage φmR11 has bifunctional lytic activity Reviewed

    Mohammad Rashel, Jumpei Uchiyama, Iyo Takemura, Hiroshi Hoshiba, Takako Ujihara, Hiroyoshi Takatsuji, Koichi Honke, Shigenobu Matsuzaki

    FEMS Microbiology Letters   284 ( 1 )   9 - 16   2008.7

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    DOI: 10.1111/j.1574-6968.2008.01152.x

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  • A novel site-specific recombination system derived from bacteriophage φ{symbol}MR11 Reviewed

    Mohammad Rashel, Jumpei Uchiyama, Takako Ujihara, Iyo Takemura, Hiroshi Hoshiba, Shigenobu Matsuzaki

    Biochemical and Biophysical Research Communications   368 ( 2 )   192 - 198   2008.4

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    DOI: 10.1016/j.bbrc.2008.01.045

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  • T-even-related bacteriophages as candidates for treatment of Escherichia coli urinary tract infections Reviewed

    H. Nishikawa, M. Yasuda, J. Uchiyama, M. Rashel, Y. Maeda, I. Takemura, S. Sugihara, T. Ujihara, Y. Shimizu, T. Shuin, S. Matsuzaki

    Archives of Virology   153 ( 3 )   507 - 515   2008.3

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    DOI: 10.1007/s00705-007-0031-4

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  • Efficacy of bacteriophage therapy against gut-derived sepsis caused by Pseudomonas aeruginosa in mice Reviewed

    Ryohei Watanabe, Tetsuya Matsumoto, Go Sano, Yoshikazu Ishii, Kazuhiro Tateda, Yoshinobu Sumiyama, Jumpei Uchiyama, Shingo Sakurai, Shigenobu Matsuzaki, Shosuke Imai, Keizo Yamaguchi

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   51 ( 2 )   446 - 452   2007.2

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    DOI: 10.1128/AAC.00635-06

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  • Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage φMR11 Reviewed

    Mohammad Rashel, Jumpei Uchiyama, Takako Ujihara, Yoshio Uehara, Shu Kuramoto, Shigeyoshi Sugihara, Ken Ichi Yagyu, Asako Muraoka, Motoyuki Sugai, Keiichi Hiramatsu, Koichi Honke, Shigenobu Matsuzaki

    Journal of Infectious Diseases   196 ( 8 )   1237 - 1247   2007

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    DOI: 10.1086/521305

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MISC

  • ファージを使った医療(第4回)ファージと生体 Reviewed

    内山 淳平

    Veterinary immunology for practitioners : 獣医免疫アレルギー学専門誌   6 ( 1 )   18 - 24   2021.1

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  • R&D of phage therapy to MRSA infections: (I) Analysis of phage culture by design of experiment Invited

    内山淳平

    日本細菌学雑誌(Web)   76 ( 1 )   2021

  • ファージを使った医療(第3回) ファージを利用した細菌検査法 Invited Reviewed

    内山 淳平

    Veterinary Immunology for Practitioners   5 ( 4 )   30 - 37   2020.10

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  • ファージを使った医療(第2回)ファージ療法 Invited Reviewed

    内山 淳平

    Veterinary immunology for practitioners : 獣医免疫アレルギー学専門誌   5 ( 3 )   36 - 41   2020.7

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    Other Link: http://search.jamas.or.jp/link/ui/2020311001

  • ファージを使った医療(第1回)ファージとは何か? Invited Reviewed

    内山 淳平

    Veterinary immunology for practitioners : 獣医免疫アレルギー学専門誌   5 ( 2 )   36 - 42   2020.4

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    Other Link: http://search.jamas.or.jp/link/ui/2020189278

  • マイクロバイオーム解析の基礎:細菌叢解析を中心に Invited

    内山淳平

    ペット栄養学会誌   21 ( 2 )   S11 - S11   2018

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    DOI: 10.11266/jpan.21.2_S11

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  • 抗ブドウ球菌エンドライシンのリンカー領域が機能に与える影響(Functional impact by shorting a linker region of a staphylococcal endolysin)

    宗友 荘介, 内山 淳平, 内山 伊代, Thamonwan Wanganuttara, 津久井 利広, 萩谷 英大, 山本 由弥子, 神田 秀幸, 松下 治

    日本細菌学雑誌   79 ( 2 )   265 - 265   2024.7

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  • Decreased cellular immunity and influence of nitrate-reducing bacteria in H. pylori infection model

    横田憲治, 内山淳平, 倉岡紗樹子, 岡上昇太郎, 河野吉泰, 岡田裕之

    日本ヘリコバクター学会学術集会プログラム・抄録集   30回   70 - 70   2024.6

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  • 【牛伝染性リンパ腫研究の現在地】牛伝染性リンパ腫ウイルスの不顕性感染と消化管細菌叢

    鈴木 武人, 村上 裕信, 内山 淳平

    臨床獣医   42 ( 6 )   14 - 19   2024.6

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  • 「動物細菌叢」の研究-ワンヘルスへの挑戦- 乳牛における子宮内細菌叢解析の産業利用の可能性

    八木沢 拓也, 内山 淳平, 片桐 成二

    日本細菌学雑誌   79 ( 2 )   38 - 38   2024.6

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  • 抗ブドウ球菌エンドライシンのリンカー領域が機能に与える影響

    宗友 荘介, 内山 淳平, 内山 伊代, Thamonwan Wanganuttara, 津久井 利広, 萩谷 英大, 山本 由弥子, 神田 秀幸, 松下 治

    日本細菌学雑誌   79 ( 2 )   119 - 119   2024.6

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  • 胃癌患者の胃内より分離した硝酸塩還元菌のピロリ菌共感染マウスへの影響

    小松原 万里奈, 山本 由弥子, 内山 淳平, 松下 治, 後藤 和義, 渡辺 朱理, 横田 憲治

    日本細菌学雑誌   79 ( 2 )   140 - 140   2024.6

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  • 胃炎-胃癌患者の胃粘膜より分離された硝酸塩還元菌の性状

    桑木 星里香, 山本 由弥子, 内山 淳平, 松下 治, 後藤 和義, 渡辺 朱理, 横田 憲治

    日本細菌学雑誌   79 ( 2 )   152 - 152   2024.6

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  • ウシにおける子宮内細菌叢と分娩後の子宮環境および繁殖性との関連

    八木沢 拓也, 片桐 成二, 内山 淳平

    家畜感染症学会誌   13 ( 2 )   43 - 49   2024.5

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  • ウシにおける子宮内細菌叢と分娩後の子宮環境および繁殖性との関連

    八木沢 拓也, 片桐 成二, 内山 淳平

    家畜感染症学会誌   13 ( 2 )   43 - 49   2024.5

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  • 緑膿菌角膜潰瘍に対する人工抗菌酵素の開発研究

    内山 淳平, 内山 伊代, 萩谷 英大, 松下 治, 福田 憲, 石田 わか, 山城 健児, 高知 大学

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集   98回・72回   np260 - np260   2024.5

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  • 抗MRSAエンドライシンの機能改良に関する検討

    宗友 荘介, 津久井 利広, 内山 伊代, 萩谷 英大, 内山 淳平, 神田 秀幸, 松下 治

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集   98回・72回   np260 - np260   2024.5

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  • 【牛の常在細菌叢】牛の子宮内細菌叢と産業利用の可能性

    八木沢 拓也, 内山 淳平

    臨床獣医   42 ( 4 )   35 - 39   2024.4

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  • 子宮内細菌叢を活用したウシの受胎性評価の可能性

    八木沢 拓也, 内山 淳平

    畜産技術 = Livestock technology   ( 825 )   2 - 7   2024.2

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  • Helicobacter pylori phage: From isolation to its particle structure determination

    内山淳平, 神谷亮佑, 宮崎直幸, 村田和義, 岩崎憲治, 松崎茂展

    日本ヘリコバクター学会学術集会プログラム・抄録集   25 ( 2 )   68 - 73   2024.1

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  • ファージセラピーの現状と課題 眼細菌感染症へのファージ療法の臨床応用を目指して

    福田 憲, 岸本 達真, 石田 わか, 内山 淳平, 松崎 茂展, 山城 健児

    感染症学雑誌   98 ( 1 )   75 - 76   2024.1

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  • ファージセラピーの現状と課題 眼細菌感染症へのファージ療法の臨床応用を目指して

    福田 憲, 岸本 達真, 石田 わか, 内山 淳平, 松崎 茂展, 山城 健児

    日本化学療法学会雑誌   72 ( 1 )   84 - 84   2024.1

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  • ピロリ菌ファージ 分離から構造決定まで

    内山 淳平, 神谷 亮佑, 宮崎 直幸, 村田 和義, 岩崎 憲治, 松崎 茂展

    日本ヘリコバクター学会誌   25 ( 2 )   68 - 73   2024.1

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  • ファージセラピーの現状と課題 眼細菌感染症へのファージ療法の臨床応用を目指して

    福田 憲, 岸本 達真, 石田 わか, 内山 淳平, 松崎 茂展, 山城 健児

    感染症学雑誌   98 ( 1 )   75 - 76   2024.1

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  • 薬剤耐性緑膿菌感染症に対する人工抗菌酵素の開発

    内山 淳平, 内山 伊代, 福田 憲, 玉井 栄治, 金丸 周司, 萩谷 英大, 松下 治

    緑膿菌感染症研究会講演記録   58回   72 - 72   2024.1

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  • 牛の常在細菌叢 牛の子宮内細菌叢と産業利用の可能性

    八木沢拓也, 内山淳平

    臨床獣医   42 ( 4 )   35 - 39   2024

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  • 薬剤耐性緑膿菌感染症に対する人工抗菌酵素の開発

    内山淳平, 内山伊代, 福田憲, 玉井栄治, 金丸周司, 萩谷英大, 松下治

    緑膿菌感染症研究会プログラム・抄録集   58th   72 - 72   2024

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  • 牛伝染性リンパ腫研究の現在地 牛伝染性リンパ腫ウイルスの不顕性感染と消化管細菌叢

    鈴木武人, 村上裕信, 内山淳平

    臨床獣医   42 ( 6 )   14 - 19   2024

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  • Commercial potential for application of uterine microbiota analysis in dairy cows

    八木沢拓也, 内山淳平, 片桐成二

    日本細菌学雑誌(Web)   79 ( 2 )   2024

  • Characteristics of nitrate-reducing bacteria from patients with gastritis and gastric cancer

    桑木星里香, 山本由弥子, 内山淳平, 松下治, 後藤和義, 渡辺朱理, 横田憲治

    日本細菌学雑誌(Web)   79 ( 2 )   2024

  • Effects of nitrate-reducing bacteria from the gastric cancer patients in H. pylori co-infected mice

    小松原万里奈, 山本由弥子, 内山淳平, 松下治, 後藤和義, 渡辺朱理, 横田憲治

    日本細菌学雑誌(Web)   79 ( 2 )   2024

  • Functional impact by linker region of a staphylococcal endolysin

    宗友荘介, 内山淳平, 内山伊代, THAMONWAN Wanganuttara, 津久井利広, 萩谷英大, 山本由弥子, 神田秀幸, 松下治

    日本細菌学雑誌(Web)   79 ( 2 )   2024

  • ファージ由来分子を利用した新たな微生物検査技術の開発

    内山 淳平

    日本臨床微生物学会雑誌   34 ( Suppl.1 )   134 - 134   2023.12

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  • ファージ由来分子を利用した新たな微生物検査技術の開発

    内山 淳平

    日本臨床微生物学会雑誌   34 ( Suppl.1 )   134 - 134   2023.12

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  • 健常犬の糞便中から分離した乳酸菌Ligilactobacillus animalisの経口摂取が運動機能に及ぼす効能についての検討

    明瀬 愛, 安田 伊武希, 金木 真央, 大平 智春, 竹田 志郎, 内山 淳平, 福山 朋季

    日本畜産学会大会講演要旨集   131回   130 - 130   2023.9

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  • 健常犬の糞便中から分離した乳酸菌Limosilactobacillus reuteriのアレルギー性接触皮膚炎症状に対する効果効能の検討

    市川 茉南, 金木 真央, 大平 智春, 安田 伊武希, 竹田 志郎, 内山 淳平, 福山 朋季

    日本畜産学会大会講演要旨集   131回   104 - 104   2023.9

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  • 健常犬の糞便中から分離した乳酸菌Ligilactobacillus animalisの妊娠期間中の摂取は仔のアレルギー性接触皮膚炎症状を抑制する

    安田 伊武希, 金木 真央, 竹田 志郎, 内山 淳平, 福山 朋季

    日本畜産学会大会講演要旨集   131回   104 - 104   2023.9

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  • 健常犬の糞便中から分離した乳酸菌Limosilactobacillus reuteriのアレルギー性接触皮膚炎症状に対する効果効能の検討

    市川 茉南, 金木 真央, 大平 智春, 安田 伊武希, 竹田 志郎, 内山 淳平, 福山 朋季

    日本畜産学会大会講演要旨集   131回   104 - 104   2023.9

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  • 健常犬の糞便中から分離した乳酸菌Ligilactobacillus animalisの妊娠期間中の摂取は仔のアレルギー性接触皮膚炎症状を抑制する

    安田 伊武希, 金木 真央, 竹田 志郎, 内山 淳平, 福山 朋季

    日本畜産学会大会講演要旨集   131回   104 - 104   2023.9

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  • 健常犬の糞便中から分離した乳酸菌Ligilactobacillus animalisの経口摂取が運動機能に及ぼす効能についての検討

    明瀬 愛, 安田 伊武希, 金木 真央, 大平 智春, 竹田 志郎, 内山 淳平, 福山 朋季

    日本畜産学会大会講演要旨集   131回   130 - 130   2023.9

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  • 乳牛における子宮内細菌叢と受胎性との関連についての検討

    八木沢 拓也, 内山 淳平, 内山 伊代, 安藤 駿, 市居 修, 村上 裕信, 松下 治, 片桐 成二

    北海道獣医師会雑誌   67 ( 8 )   294 - 294   2023.8

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  • Helicobacter pylori phage: From isolation to its particle structure determination

    内山淳平, 神谷亮佑, 宮崎直幸, 村田和義, 岩崎憲治, 松崎茂展

    日本ヘリコバクター学会学術集会プログラム・抄録集   29回 ( 2 )   84 - 84   2023.6

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  • Helicobacter pylori phage: From isolation to its particle structure determination

    内山淳平, 神谷亮佑, 宮崎直幸, 村田和義, 岩崎憲治, 松崎茂展

    日本ヘリコバクター学会学術集会プログラム・抄録集   29回 ( 2 )   84 - 84   2023.6

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  • 新規に分離したバクテリオファージ候補3種(phiEF7H、phiEF14H1、phiEF19G)の腸球菌性眼内炎に対するin vitroおよびin vivo評価(In vitro and in vivo evaluation of three newly isolated bacteriophage candidates, phiEF7H, phiEF14H1, phiEF19G, for treatment of Enterococcus faecalis endophthalmitis)

    Kishimoto Tatsuma, Ishida Waka, Nasukawa Tadahiro, Ujihara Takako, Nakajima Isana, Suzuki Takashi, Uchiyama Jumpei, Todokoro Daisuke, Daibata Masanori, Fukushima Atsuki, Matsuzaki Shigenobu, Fukuda Ken

    日本眼科学会雑誌   127 ( 臨増 )   166 - 166   2023.3

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  • 細菌性コラゲナーゼの構造活性相関の解析(Structure-function analysis of Clostridial collagenases)

    Asaduzzaman Md, 美間 健彦, 後藤 和義, 山本 由弥子, 内山 淳平, Sakon Joshua, 松下 治

    日本細菌学雑誌   78 ( 1 )   136 - 136   2023.2

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  • ファージvs細菌 その仁義なき?戦い ウラシル含有DNAゲノムを有する巨大ファージの細菌進化への影響

    内山 淳平, 内山 伊代, 後藤 和義, 山本 由弥子, 松崎 茂展, 松下 治

    日本細菌学雑誌   78 ( 1 )   19 - 19   2023.2

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  • Rodentibacter pneumotropicus表現型の多様性を生み出す可能性のある要因について

    池 郁生, 佐々木 啓, 内山 淳平, 豊田 敦

    日本細菌学雑誌   78 ( 1 )   83 - 83   2023.2

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  • 細菌性コラゲナーゼの構造活性相関の解析(Structure-function analysis of Clostridial collagenases)

    Asaduzzaman Md, 美間 健彦, 後藤 和義, 山本 由弥子, 内山 淳平, Sakon Joshua, 松下 治

    日本細菌学雑誌   78 ( 1 )   136 - 136   2023.2

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  • ファージvs細菌 その仁義なき?戦い ウラシル含有DNAゲノムを有する巨大ファージの細菌進化への影響

    内山 淳平, 内山 伊代, 後藤 和義, 山本 由弥子, 松崎 茂展, 松下 治

    日本細菌学雑誌   78 ( 1 )   19 - 19   2023.2

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  • 初回人工授精前の子宮内膜組織を用いた乳牛の低受胎に関わる子宮内細菌叢の解析

    八木沢 拓也, 内山 淳平, 内山 伊代, 安藤 駿, 市居 修, 村上 裕信, 松下 治, 片桐 成二

    日本細菌学雑誌   78 ( 1 )   72 - 72   2023.2

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  • 初回人工授精前の子宮内膜組織を用いた乳牛の低受胎に関わる子宮内細菌叢の解析

    八木沢 拓也, 内山 淳平, 内山 伊代, 安藤 駿, 市居 修, 村上 裕信, 松下 治, 片桐 成二

    日本細菌学雑誌   78 ( 1 )   72 - 72   2023.2

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  • Rodentibacter pneumotropicus表現型の多様性を生み出す可能性のある要因について

    池 郁生, 佐々木 啓, 内山 淳平, 豊田 敦

    日本細菌学雑誌   78 ( 1 )   83 - 83   2023.2

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  • Analysis of animal-derived rare actinomycetes as a new source of bioactive compounds.

    模素希, 中村洸, 谷田貝紗有, 加瀬ちひろ, 加瀬ちひろ, 相原尚之, 相原尚之, 片平浩孝, 風間啓, 内山淳平, 紙透伸治, 紙透伸治

    日本農芸化学会大会講演要旨集(Web)   2023   2023

  • Characterization of endometrial microbiota associated with low fertility in dairy cows

    八木沢拓也, 内山淳平, 内山伊代, 安藤駿, 市居修, 村上裕信, 松下治, 片桐成二

    日本細菌学雑誌(Web)   78 ( 1 )   2023

  • Factors that may produce phenotypic diversity of Rodentibacter pneumotropicus

    池郁生, 佐々木啓, 内山淳平, 豊田敦

    日本細菌学雑誌(Web)   78 ( 1 )   2023

  • Implications for bacterial evolution of giant phages with uracil-containing DNA genomes

    内山淳平, 内山伊代, 後藤和義, 山本由弥子, 松崎茂展, 松下治

    日本細菌学雑誌(Web)   78 ( 1 )   2023

  • 食肉製品の腐敗性乳酸菌に対するファージエンドライシンの抗菌効果

    小方雅也, 田邊奏, 三嶋花, 内山淳平, 田原口智士, 水野谷航, 竹田志郎

    家畜衛生学雑誌   49 ( 3 )   2023

  • 眼細菌感染症へのファージ療法の臨床応用を目指して

    福田憲, 岸本達真, 石田わか, 内山淳平, 松崎茂展, 山城健児

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集   72nd-70th ( 1 )   84 - 84   2023

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  • 乳牛における子宮内細菌叢と受胎性との関連についての検討

    八木沢拓也, 内山淳平, 内山伊代, 安藤駿, 市居修, 村上裕信, 松下治, 片桐成二

    北海道獣医師会雑誌   67 ( 8 )   294 - 294   2023

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  • Total Quality Assurance for Animal Diagnostic Laboratory Testing

    関根康司, 五野上誠, 久枝啓一, 畑明寿, 畑明寿, 藤谷登, 藤谷登, 谷あすか, 桐谷光夫, 鈴木幸一, 細井英司, 内山(竹村)伊代, 内山淳平, 渡辺俊平, 宮井紗弥香, 岡崎登志夫, 後藤一雄, 荒木千章, 有坂麻子, 金木信敏, 吉田隆, 濱野正敬, 大藤圭子, 西口慶一, 渭原博, 畠岳也, 清水園枝, 原瑞姫, 古本佳代, 古本佳代, 中内暁博, 熊澤武志, 佐藤瑛美, 松本崇, 西河淳, 亀島政範, 小野文子

    ワンヘルスサイエンス(Web)   6 ( 1 )   2023

  • Commonly identified phage-derived genes among the genomes of Rodentibacter pneumotropicus isolates

    池郁生, 佐々木啓, 内山淳平, 豊田敦

    日本ウイルス学会学術集会プログラム・予稿集(Web)   70th   2023

  • 細菌感染症創薬に向けた「次世代型抗菌酵素」の創出

    内山淳平, 内山伊代, 福田憲, 玉井栄治, 金丸周司, 萩谷英大, 松下治

    微生物シンポジウム講演要旨集   35th   2023

  • ピロリ菌を除菌可能な食べれる人工抗菌酵素剤の研究開発

    内山 淳平

    研究報告書 三島海雲記念財団 [編]   ( 60 )   1 - 4   2023

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  • 牛伝染性リンパ腫ウイルスの不顕性感染に関する乳牛の消化管の揮発性脂肪酸および細菌叢の横断的調査

    鈴木武人, 村上裕信, 内山淳平, 佐藤礼一郎, 内山伊代, 小方雅也, 曽川一幸, 石田大歩, 松下治, 長井誠

    日本ワンヘルスサイエンス学会年次学術集会抄録集(Web)   7th   2023

  • 食肉加工におけるEnterococcus faecalisに特異的なファージエンドライシンの殺菌効果

    小方雅也, 田邊奏, 三嶋花, 内山淳平, 田原口智士, 水野谷航, 竹田志郎

    日本食品科学工学会大会講演集   70th   2023

  • 腸内細菌を介した酸素ナノバブル水による抗腫瘍作用

    永根 大幹, 鈴木 利美奈, 水垣 ひなの, 丹羽 智瑛, 内山 淳平, 稲波 修, 赤羽 英夫, 安井 博宣, 山下 匡

    日本生化学会大会プログラム・講演要旨集   95回   2P - 273   2022.11

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  • 腸内細菌を介した酸素ナノバブル水による抗腫瘍作用

    永根 大幹, 鈴木 利美奈, 水垣 ひなの, 丹羽 智瑛, 内山 淳平, 稲波 修, 赤羽 英夫, 安井 博宣, 山下 匡

    日本生化学会大会プログラム・講演要旨集   95回   2P - 273   2022.11

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  • 分娩後子宮捻転を発症した乳牛の子宮内細菌叢解析

    風間 啓, 内山 淳平, 恩田 賢

    日本獣医学会学術集会講演要旨集   165回   [HL1P - 01]   2022.9

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  • 健常犬の糞便中から分離した乳酸菌AZABU株はヒト単球細胞をM2bマクロファージに分化誘導する

    安田 伊武希, 金木 真央, 竹田 志郎, 内山 淳平, 福山 朋季

    日本獣医学会学術集会講演要旨集   165回   [J2A - 02]   2022.9

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  • イヌにおける胆嚢の常在細菌叢の存在の検討と肝疾患に関連した細菌叢解析

    経田 真梨菜, 根尾 櫻子, 内山 伊代, 内山 淳平, 村上 裕信, 島 綾香, 茅沼 秀樹, 横山 大希, 高木 哲, 金井 詠一, 久末 正晴, 葛原 早瑛

    日本獣医学会学術集会講演要旨集   165回   [HS1P - 15]   2022.9

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  • 分娩後子宮捻転を発症した乳牛の子宮内細菌叢解析

    風間 啓, 内山 淳平, 恩田 賢

    日本獣医学会学術集会講演要旨集   165回   [HL1P - 01]   2022.9

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  • イヌにおける胆嚢の常在細菌叢の存在の検討と肝疾患に関連した細菌叢解析

    経田 真梨菜, 根尾 櫻子, 内山 伊代, 内山 淳平, 村上 裕信, 島 綾香, 茅沼 秀樹, 横山 大希, 高木 哲, 金井 詠一, 久末 正晴, 葛原 早瑛

    日本獣医学会学術集会講演要旨集   165回   [HS1P - 15]   2022.9

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  • 健常犬の糞便中から分離した乳酸菌AZABU株はヒト単球細胞をM2bマクロファージに分化誘導する

    安田 伊武希, 金木 真央, 竹田 志郎, 内山 淳平, 福山 朋季

    日本獣医学会学術集会講演要旨集   165回   [J2A - 02]   2022.9

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  • Helicobacter pylori株の長期凍結保存(Long-term cryopreservation of Helicobacter pylori strains)

    Hayashi Shunji, Uchiyama Jumpei, Yokota Kenji, Shimomura Hirofumi

    日本ヘリコバクター学会学術集会プログラム・抄録集   28回   185 - 185   2022.6

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  • Potential therapeutic effects of ozone water on pyoderma and atopic dermatitis in dogs

    Kaneki Mao, Takahashi Miyu, Uchiyama Jumpei, Ano Tetsuya, Fukuyama Tomoki

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   95   1-SS-64   2022

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    Ozone water is currently utilized for antibacterial and antiviral purposes under the pandemic of COVID-19 due to its strong oxidation effect without safety problems. Therefore, clinical applications of ozone water for cutaneous diseases such as atopic dermatitis (AD) and pyoderma are expected recently. The aim of this project is to apply the ozone water for AD and pyoderma in dogs. We here examined the antibacterial effects of ozone water using staphylococci in in vitro setting, and anti-allergic effects of ozone water in AD mouse model.

    We first examined the bactericidal effect of ozone water on resident staphylococci on skin. Staphylococcus aureus, which is an exacerbating factor in human AD, and S. lentus collected from AD mouse model was treated with ozone water and the number of bacteria was determined. Our findings indicated that ozone water showed a significant bactericidal effect against both staphylococcal species . We are currently investigating the efficacy of ozone water against staphylococci isolated from AD and pyoderma dogs. In vivo experiment with AD mouse model is also underway to look for the therapeutic effects of ozone water with impact on inflammatory and itch responses.

    DOI: 10.1254/jpssuppl.95.0_1-ss-64

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  • Ozone water as a potential preventive and therapeutic option for periodontal disease in dogs

    Tomoki Fukuyama, Kaneki Mao, Oohira Chiharu, Uchiyama Jumpei, Ano Tetsuya

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   95   2-O-090   2022

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    Periodontal disease, which is majorly caused by Porphyromonas gulae, is extremely common in dogs, and is associated with serious systemic diseases such as kidney failure, heart disease and immune disorder. Ozon water is ozone-gas-dissolved water, which has antimicrobial activity by oxidizing molecules. However, both therapeutic and preventive effects of ozone water for periodontal disease in dogs are still unclear. We herein examined the antibacterial and anti-inflammatory effects of ozone water in vitro using P. gulae. Our results indicated that treatment of ozone water significantly inhibited the growth of P. gulae until 24h post ozone water treatment as compared to purified water treatment. Ozone water also showed the anti-inflammatory effects in P. gulae-infected human gingival epithelial cells (Ca9-22). Secretions of IL-1β and TNFα were significantly suppressed by ozone water treatment compared to the treatment of purified water. As IL-1β and TNFα activate the osteoclast and finally promote bone resorption in the oral cavity, our findings imply the potential therapeutic and preventive effects of ozone water in canine periodontal disease. We are currently investigating the in vivo preventive and therapeutic effects of ozone water in dogs.

    DOI: 10.1254/jpssuppl.95.0_2-o-090

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  • 白内障術後眼内炎に対するバクテリオファージによる発症予防効果の検討

    岸本達真, 石田わか, 中島勇魚, 鈴木崇, 内山淳平, 松崎茂展, 福田憲, 山城健児

    日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集   58th-55th-64th-10th   2022

  • 純血種柴犬を使用したアトピー性皮膚炎に関連した口腔・糞便細菌叢の特徴付け

    内山淳平, 大隅尊史, 水上圭二郎, 福山朋季, 島綾香, 海野朝香, 内山伊代, 宇根有美, 村上裕信, 阪口雅弘, 阪口雅弘

    日本ワンヘルスサイエンス学会年次学術集会抄録集(Web)   6th   2022

  • Microbiome analysis of bovine uterine, aiming to creation of novel technology improving low fertility

    内山淳平, 八木沢拓也, 片桐成二

    食肉に関する助成研究調査成果報告書   40   2022

  • Topical treatment with high concentration of ozone water ameliorates inflammatory responses and breakdown of the cutaneous barrier in a mouse model of atopic dermatitis through antibacterial effect toward staphylococci

    Kaneki Mao, Ohira Chiharu, Takahashi Miyu, Uchiyama Jumpei, Ano Tetsuya, Fukuyama Tomoki

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   96   2-B-P-170   2022

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    We focus on the ozone water to develop a novel treatment approach for staphylococci related inflammatory skin diseases. In the 95th Annual Meeting of the Japanese Pharmacological Society, we reported the anti-allergic and anti-microbial effect of 3 mg/L ozone water in a mouse model of atopic dermatitis (AD) and staphylococci, however, its effect was far from clinical application. The aim of this study is to evaluate the anti-microbial and anti-inflammatory property of high concentration (11 mg/L) of ozone water to advance our project. Ozone water showed a significant bactericidal effect against Staphylococcus aureus, S. pseudintermedius and S. lentus. Furthermore, S. pseudintermedius induced IL-1β and IL-6 secretion in human epidermal keratinocytes was significantly inhibited by pre-treatment of ozone water. In vivo experiment with a mouse model of AD, significant improvement of AD symptoms and trans epidermal water loss were also found in an ozone water treatment group. Surprisingly, local immune reactions such as type II conventional dendritic cells, effector helper T cells, and IgE-produced B cells are also regulated by ozone water application. Our findings strongly suggest that topical treatment with high concentration of ozone water significantly ameliorated AD symptoms through antibacterial effect toward staphylococci.

    DOI: 10.1254/jpssuppl.96.0_2-b-p-170

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  • Examining anti-allergic properties of live and killed Lactbacillus reuteri isolated from healthy dogs in a mouse model of atopic dermatitis.

    Ichikawa Mana, Hayakawa Chiharu, Ohira Chiharu, Kaneki Mao, Yasuda Ibuki, Takeda Shirou, Uchiyama Jumpei, Fukuyama Tomoki

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   96   2-B-P-173   2022

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    We are currently developing Lactobacillus reuteri isolated from healthy dogs as a probiotic supplement for canine atopic dermatitis (AD). In this study, we examined the anti-allergic effects of live L. reuteri and killed L. reuteri strain mixture (i.e., strains M01, M11, M40, and M41) using a hapten-induced-AD mouse model. First, when UV-killed L. reuteri (overgrowth) was orally administered to AD mice, cutaneous barrier function evaluated by the trans epidermal water loss was maintained as normal in the L. reuteri treatment group, compared with the control group. Immune reactions including lymphocyte proliferation in auricular lymph nodes and total IgE levels in serum are significantly regulated by treatment of killed L. reuteri. In contrast, L. reuteri treatment improve neither AD score nor skin thickness. Second, the anti-AD effects were examined using 4 individual strains of live L. reuteri (i.e., M01, M11, M40, or M41). The symptoms of AD and immune responses such as lymphocyte proliferation and total IgE levels are significantly reduced by L. reuteri M11 administration compared with the vehicle control and other strains. Currently, the interaction with macrophages and regulatory T cells is being studied.

    DOI: 10.1254/jpssuppl.96.0_2-b-p-173

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  • Oral administration of Lactobacillus AZABU isolated from the gut microbiome of healthy dogs significantly prevents the development of atopic dermatitis and allergic asthma in mice models.

    Chiharu Hayakawa, Ohira Chiharu, Kaneki Mao, Yasuda Ibuki, Ichikawa Mana, Takeda Shiro, Uchiyama Jumpei, Fukuyama Tomoki

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   96   2-B-P-172   2022

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    Regulation of the gut microbiome using probiotics such as Lactobacillus spp. is recently focused on as one of the preventive measures for allergy. We originally isolated Lactobacillus sp. (L. AZABU) from the healthy dog guts. We here evaluated the anti-allergic effects of L. AZABU using hapten-induced atopic dermatitis (AD) and asthma mouse models. First, daily oral administration of live L. AZABU (2×108 CFU/ml) during the experimental period significantly prevented the development of AD symptoms, skin thickness, and trans-epidermal water loss in the AD mouse model. Significant decreased number of IgE-positive B cells in auricular lymph node was also observed in L. AZABU treatment group, indicating allergen-specific immunoreaction was regulated by L. AZABU. Group 2 innate lymphoid cells, which play a pivotal role in non-allergen-specific immunoreaction, also significantly suppressed by oral administration of live L. AZABU. Next, the anti-allergic effects of live L. AZABU was simultaneously demonstrated in the asthma mouse model, including significant decrease of inflammatory pathological change of lung, and both allergen-specific and non-specific immunoreaction in hilar lymph node and lung tissue. Our findings suggested that live L. AZABU has anti-allergic properties although the mechanism of action is still being investigated.

    DOI: 10.1254/jpssuppl.96.0_2-b-p-172

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  • ブドウ球菌ファージS6を使用したウラシル含有DNAゲノムを有する巨大ファージ群の系統解析

    内山淳平, 内山伊代, 後藤和義, 加藤伸一郎, 阪口義彦, 村上裕信, 福山朋季, 金木真央, 松下治, 松崎茂展

    日本ブドウ球菌研究会プログラム・抄録集(Web)   66th   2022

  • 妊娠後期のB群連鎖球菌検査の精度を改善のためのファージ酵素の利用

    内山 淳平, 松井 秀仁, 小方 雅也, 那須川 忠弥, 内山 伊代, 加藤 伸一郎, 今西 市朗, 東出 正人, 花木 秀明

    日本獣医学会学術集会講演要旨集   164回   [DBO - 24]   2021.9

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  • 正常犬の糞便中から分離した乳酸菌AZABU株生菌の経口投与がアトピー性皮膚炎モデルマウスの炎症およびそう痒に及ぼす効果検討

    早川 千春, 内山 淳平, 久末 正晴, 根尾 櫻子, 村上 裕信, 五十嵐 寛高, 宮武 昌一郎, 阪口 雅弘, 福山 朋季

    日本獣医学会学術集会講演要旨集   164回   [JO - 17]   2021.9

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  • アレルゲン不活化剤の新規評価法としてのドットブロット法の開発

    吉田 愛美, 水上 圭二郎, 蔵田 圭吾, 那須川 忠弥, 内山 淳平, 阪口 雅弘

    アレルギー   70 ( 6-7 )   875 - 875   2021.8

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  • アレルゲン不活化剤の新規評価法としてのドットブロット法の開発

    吉田 愛美, 水上 圭二郎, 蔵田 圭吾, 那須川 忠弥, 内山 淳平, 阪口 雅弘

    アレルギー   70 ( 6-7 )   875 - 875   2021.8

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  • 膿痂疹の自然発症動物モデル(イヌ表在性膿皮症)に対するファージ由来酵素エンドライシンの検討

    今西 市朗, 西藤 公司, 朝比奈 良太, 林 俊治, 津久井 利広, 内山 淳平

    感染症学雑誌   95 ( 臨増 )   313 - 313   2021.4

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  • GBS検査の精度を改善するためのファージ酵素エンドライシンの利用

    内山 淳平, 松井 秀仁, 小方 雅也, 那須川 忠弥, 内山 伊代, 東出 正人, 阪口 雅弘, 花木 秀明

    感染症学雑誌   95 ( 臨増 )   313 - 313   2021.4

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  • GBS検査の精度を改善するためのファージ酵素エンドライシンの利用

    内山 淳平, 松井 秀仁, 小方 雅也, 那須川 忠弥, 内山 伊代, 東出 正人, 阪口 雅弘, 花木 秀明

    感染症学雑誌   95 ( 臨増 )   313 - 313   2021.4

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  • 膿痂疹の自然発症動物モデル(イヌ表在性膿皮症)に対するファージ由来酵素エンドライシンの検討

    今西 市朗, 西藤 公司, 朝比奈 良太, 林 俊治, 津久井 利広, 内山 淳平

    感染症学雑誌   95 ( 臨増 )   313 - 313   2021.4

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  • 密度勾配超遠心法とフローサイトメトリーを併用したグラム陽性細菌が産生する膜小胞試料の調製法の検討

    那須川 忠弥, 杉本 良輔, 内山 淳平, 内山 伊代, 村上 裕信, 福田 憲, 松崎 茂展, 阪口 雅弘

    日本細菌学雑誌   76 ( 1 )   83 - 83   2021.2

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  • 黄色ブドウ球菌に対するファージ療法の研究開発 実験計画法によるファージ培養の解析 Invited

    内山 淳平

    日本細菌学雑誌   76 ( 1 )   9 - 9   2021.2

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  • 密度勾配超遠心法とフローサイトメトリーを併用したグラム陽性細菌が産生する膜小胞試料の調製法の検討

    那須川 忠弥, 杉本 良輔, 内山 淳平, 内山 伊代, 村上 裕信, 福田 憲, 松崎 茂展, 阪口 雅弘

    日本細菌学雑誌   76 ( 1 )   83 - 83   2021.2

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  • ファージ由来溶菌酵素S25-3LYSのイヌ表在性膿皮症に対する臨床応用性の検討

    今西 市朗, 西藤 公司, 朝比奈 良太, 林 俊治, 津久井 利弘, 内山 淳平

    日本細菌学雑誌   76 ( 1 )   123 - 123   2021.2

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  • 黄色ブドウ球菌に対するファージ療法の研究開発 実験計画法によるファージ培養の解析

    内山 淳平

    日本細菌学雑誌   76 ( 1 )   9 - 9   2021.2

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  • GBS検査を改善するエンドライシンの新規利用法検討

    小方 雅也, 松井 秀仁, 那須川 忠弥, 内山 伊代, 東出 正人, 阪口 雅弘, 花木 秀明, 内山 淳平

    日本細菌学雑誌   76 ( 1 )   66 - 66   2021.2

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  • ファージ由来溶菌酵素S25-3LYSのイヌ表在性膿皮症に対する臨床応用性の検討

    今西 市朗, 西藤 公司, 朝比奈 良太, 林 俊治, 津久井 利弘, 内山 淳平

    日本細菌学雑誌   76 ( 1 )   123 - 123   2021.2

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  • 菌種同定に難渋した感染性心内膜炎の1例

    岡村 駿, 明城 正博, 杉下 靖之, 田部井 史子, 佐藤 優佳理, 今西 市朗, 内山 淳平, 伊從 慶太, 曾和 裕之

    日本内科学会関東地方会   666回   30 - 30   2021.2

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  • GBS検査を改善するエンドライシンの新規利用法検討

    小方 雅也, 松井 秀仁, 那須川 忠弥, 内山 伊代, 東出 正人, 阪口 雅弘, 花木 秀明, 内山 淳平

    日本細菌学雑誌   76 ( 1 )   66 - 66   2021.2

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  • GBS培養検査で問題となる偽陰性を改善する新規選択的抗菌剤の技術開発

    小方 雅也, 松井 秀仁, 那須川 忠弥, 内山 伊代, 東出 正人, 阪口 雅弘, 花木 秀明, 内山 淳平

    神奈川医学会雑誌   48 ( 1 )   69 - 69   2021.1

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  • 強制劣化したソーセージ細菌叢の解析とくん液添加による影響

    竹田志郎, 内山淳平, 木下由貴, 水野谷航, 坂田亮一

    日本食肉研究会総会提出議案及び大会講演要旨   62nd (CD-ROM)   2021

  • GBS検査の精度を改善するためのファージ酵素エンドライシンの利用

    内山淳平, 松井秀仁, 小方雅也, 那須川忠弥, 内山伊代, 東出正人, 阪口雅弘, 花木秀明

    日本化学療法学会雑誌   69 ( Supplement-A )   2021

  • Clinical applicability of phage-derived lytic enzyme S25-3LYS to canine superficial pyoderma

    今西市朗, 西藤公司, 朝比奈良太, 林俊治, 津久井利弘, 内山淳平

    日本細菌学雑誌(Web)   76 ( 1 )   2021

  • Purification of membrane vesicles from Gram-positive bacteria using flow cytometry

    那須川忠弥, 杉本良輔, 内山淳平, 内山伊代, 村上裕信, 福田憲, 松崎茂展, 阪口雅弘

    日本細菌学雑誌(Web)   76 ( 1 )   2021

  • Colorimetric detection of bacteria pathogens through aggregation of gold nanoparticles induced by thiolated bacteriophages

    山下智史, 仁子陽輔, 波多野慎悟, 渡辺茂, 内山伊代, 内山淳平, 松崎茂展

    日本化学会春季年会講演予稿集(Web)   101st   2021

  • 膿痂疹の自然発症動物モデル(イヌ表在性膿皮症)に対するファージ由来酵素エンドライシンの検討

    今西市朗, 西藤公司, 朝比奈良太, 林俊治, 津久井利広, 内山淳平

    日本化学療法学会雑誌   69 ( Supplement-A )   2021

  • Examination of novel application of endolysin to improve GBS test

    小方雅也, 松井秀仁, 那須川忠弥, 内山伊代, 東出正人, 阪口雅弘, 花木秀明, 内山淳平

    日本細菌学雑誌(Web)   76 ( 1 )   2021

  • 酸素ナノバブル水の抗腫瘍作用に関する基礎的研究

    永根大幹, 丹羽智瑛, 内山淳平, 稲波修, 山下匡

    日本酸化ストレス学会学術集会プログラム・抄録集   74th (CD-ROM)   2021

  • 新規腸球菌バクテリオファージによる腸球菌眼内炎に対するファージ療法の効果

    岸本達真, 石田わか, 鈴木崇, 内山淳平, 松崎茂展, 大畑雅典, 戸所大輔, 福田憲, 福島敦樹

    日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集   57th-54th-63rd-9th   2021

  • 正常犬の糞便中から分離した乳酸菌AZABU株生菌の経口投与がアトピー性皮膚炎モデルマウスの炎症および掻痒に及ぼす効果検討

    早川千春, 内山淳平, 久末正晴, 根尾櫻子, 村上裕信, 五十嵐寛高, 宮武昌一郎, 阪口雅弘, 福山朋季

    日本獣医学会学術集会講演要旨集   164th (CD-ROM)   [JO - 17]   2021

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  • 妊娠後期のB群連鎖球菌検査の精度を改善のためのファージ酵素の利用

    内山淳平, 内山淳平, 松井秀仁, 小方雅也, 那須川忠弥, 内山伊代, 加藤伸一郎, 今西市朗, 東出正人, 花木秀明

    日本獣医学会学術集会講演要旨集   164th (CD-ROM)   [DBO - 24]   2021

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  • Intracellular signaling pathways which can regulate the replication of African pygmy hedgehog adenovirus

    文榕鐸, 落合秀治, 内山淳平, 大澤南菜子, 大場真己, 片山幸枝, 黎凱欣, 大松勉, 田向健一, 鈴木馨, 斑目広郎, 牧野伸治, 水谷哲也

    日本ウイルス学会学術集会プログラム・予稿集(Web)   68th   2021

  • Staphylococcus pseudintermediusに対する新規エンドライシンの分離と解析

    金木 真央, 内山 淳平, 松崎 茂展, 内山 伊代, 小方 雅也, 阪口 雅弘

    日本獣医学会学術集会講演要旨集   163回   215 - 215   2020.10

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  • イヌの純血種コロニーを利用したアトピー性皮膚炎に関連した口腔・腸内細菌叢の変動の解析

    海野 朝香, 今西 市朗, 水上 圭二郎, 大隅 尊史, 五十嵐 寛高, 村上 裕信, 島 綾香, 石原 玄基, 宇根 有美, 阪口 雅弘, 内山 淳平

    日本獣医学会学術集会講演要旨集   163回   216 - 216   2020.10

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  • Staphylococcus pseudintermediusのイヌアトピー性皮膚炎増悪因子の探索

    鶴井 大幹, 島倉 秀勝, 内山 淳平, 今西 市朗, 坂本 修士, 樋口 琢磨, 伊從 慶太, 下池 健太, 藤村 正人, 阪口 雅弘

    日本獣医学会学術集会講演要旨集   163回   216 - 216   2020.10

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  • フローサイトメーターを利用したグラム陽性細菌の膜小胞の新規分離法

    杉本 良輔, 那須川 忠弥, 内山 淳平, 内山 伊代, 村上 裕信, 福田 憲, 松崎 茂展, 阪口 雅弘

    日本獣医学会学術集会講演要旨集   163回   215 - 215   2020.10

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  • 建築様式および換気方式の異なる住宅における花粉侵入数の検討

    白井 秀治, 山口 裕礼, 小原 雄大, 吉田 誠, 渡邉 直人, 牧野 荘平, 内山 淳平, 阪口 雅弘

    アレルギー   69 ( 臨時増刊号 )   299 - 299   2020.10

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  • 感染細胞のシグナル伝達の活性化がハリネズミアデノウイルス増殖に及ぼす影響

    文 榕鐸, 落合 秀治, 内山 淳平, 大澤 南菜子, 田向 健一, 鈴木 馨, 大場 真己, 片山 幸枝, 斑目 広郎, 牧野 伸治, 水谷 哲也

    日本獣医学会学術集会講演要旨集   163回   235 - 235   2020.10

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  • 犬の糞便細菌叢移植における移植経路についての基礎的検討

    伊藤 哲之, 五十嵐 寛高, 内山 淳平, 新田 卓, 久末 正晴

    日本獣医学会学術集会講演要旨集   163回   285 - 285   2020.10

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  • 建築様式および換気方式の異なる住宅における花粉侵入数の検討

    白井 秀治, 山口 裕礼, 小原 雄大, 吉田 誠, 渡邉 直人, 牧野 荘平, 内山 淳平, 阪口 雅弘

    アレルギー   69 ( 臨時増刊号 )   299 - 299   2020.10

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  • ダニおよびスギ花粉アレルゲンに対する不活性化剤の効果を評価する新規ドットブロット法(New dot-blot methods for evaluating the effect of inactivators on mite and Japanese cedar pollen allergens)

    Yoshida Megumi, Mizukami Keijiro, Kurata Keigo, Nasukawa Tadahiro, Uchiyama Jumpei, Sakaguchi Masahiro

    アレルギー   69 ( 臨時増刊号 )   119 - 119   2020.10

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  • 建築様式および換気システムの違いが住宅内のダニアレルゲン(Der 1)レベルの季節変化に及ぼす影響(Effect of different architectural styles and ventilation systems on seasonal changes of mite allergen (Der 1) levels in houses)

    Shirai Hideharu, Yamaguchi Hiromichi, Kohara Yudai, Yoshida Makoto, Ishihara Junko, Uchiyama Jumpei, Sakaguchi Masahiro

    アレルギー   69 ( 臨時増刊号 )   116 - 116   2020.10

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  • バクテリオファージを利用した高選択的な細菌検出技術の開発

    今井 斉志, 仁子 陽輔, 波多野 慎悟, 渡辺 茂, 内山 伊代, 内山 淳平, 松崎 茂展

    日本分析化学会講演要旨集   69年会   324 - 324   2020.9

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  • エンドリシン製剤開発に向けて ブドウ球菌ファージS6の新規エンドリシンの分離

    金木 真央, 内山 淳平, 松崎 茂展, 内山 伊代, 小方 雅也, 林 俊治, 阪口 雅弘

    神奈川医学会雑誌   47 ( 2 )   233 - 234   2020.7

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  • GBS培養検査の精度を改善する選択的抗菌剤の技術開発

    小方 雅也, 松井 秀仁, 内山 淳平, 東出 正人, 内山 伊代, 金木 真央, 松崎 茂展, 花木 秀明, 阪口 雅弘

    神奈川医学会雑誌   47 ( 2 )   233 - 233   2020.7

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  • エンドリシン製剤開発に向けて ブドウ球菌ファージS6の新規エンドリシンの分離

    金木 真央, 内山 淳平, 松崎 茂展, 内山 伊代, 小方 雅也, 林 俊治, 阪口 雅弘

    神奈川医学会雑誌   47 ( 2 )   233 - 234   2020.7

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  • GBS培養検査の精度を改善する選択的抗菌剤の技術開発

    小方 雅也, 松井 秀仁, 内山 淳平, 東出 正人, 内山 伊代, 金木 真央, 松崎 茂展, 花木 秀明, 阪口 雅弘

    神奈川医学会雑誌   47 ( 2 )   233 - 233   2020.7

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  • Omics analysis in fecal transplantation therapy for Clostridioides difficile infection

    阪口義彦, 後藤和義, 妹尾充敏, 武晃, 内山淳平, 尾崎隼人, 城代康貴, 林俊治, 大宮直木, 加藤はる

    日本薬学会年会要旨集(CD-ROM)   140年会   28P - am101   2020.3

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  • Omics analysis in fecal transplantation therapy for Clostridioides difficile infection

    阪口義彦, 後藤和義, 妹尾充敏, 武晃, 内山淳平, 尾崎隼人, 城代康貴, 林俊治, 大宮直木, 加藤はる

    日本薬学会年会要旨集(CD-ROM)   140年会   28P - am101   2020.3

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  • ファージ・シンポジウム-忘れられていた治療法の復活- 薬剤耐性菌に対するファージセラピーの概説 Invited

    内山 淳平

    感染症学雑誌   94 ( 臨増 )   229 - 229   2020.3

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  • ファージ・シンポジウム-忘れられていた治療法の復活- 薬剤耐性菌に対するファージセラピーの概説 Invited

    内山 淳平

    感染症学雑誌   94 ( 臨増 )   229 - 229   2020.3

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  • 妊婦のGBSスクリーニングテストの検査精度を向上する試薬の開発

    小方 雅也, 内山 淳平, 松井 秀仁, 内山 伊代, 那須川 忠弥, 松崎 茂展, 花木 秀明, 阪口 雅弘

    日本細菌学雑誌   75 ( 1 )   68 - 68   2020.1

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  • 妊婦のGBSスクリーニングテストの検査精度を向上する試薬の開発

    小方 雅也, 内山 淳平, 松井 秀仁, 内山 伊代, 那須川 忠弥, 松崎 茂展, 花木 秀明, 阪口 雅弘

    日本細菌学雑誌   75 ( 1 )   68 - 68   2020.1

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  • グラム陽性細菌が産生する膜小胞の精製法の検討

    那須川 忠弥, 杉本 良輔, 島倉 秀勝, 小方 雅也, 福田 憲, 松崎 茂展, 内山 淳平

    日本細菌学雑誌   75 ( 1 )   73 - 73   2020.1

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  • 牛白血病ウイルス感染による乳牛の腸内細菌叢の解析

    内山 淳平, 村上 裕信, 佐藤 礼一郎, 水上 圭二郎, 鈴木 武人, 島 綾香, 石原 玄基, 阪口 義彦, 曽川 一幸, 阪口 雅弘

    日本細菌学雑誌   75 ( 1 )   126 - 126   2020.1

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  • イヌにおけるアトピー性皮膚炎病態に関与するStaphylococcus pseudintermedius分子の探索

    島倉 秀勝, 鶴井 大幹, 坂本 修士, 樋口 琢磨, 伊從 慶太, 下池 健太, 阪口 雅弘, 内山 淳平

    日本細菌学雑誌   75 ( 1 )   157 - 157   2020.1

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  • 組換えendolysinのブドウ球菌に対する溶菌作用ならびに膿痂疹モデルマウスにおける発症抑制効果

    今西 市朗, 内山 淳平, 津久井 利広, 久恒 順三, 井手 香織, 松崎 茂展, 菅井 基行, 西藤 公司

    日本細菌学雑誌   75 ( 1 )   97 - 97   2020.1

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  • Clostridioides difficile感染症に対する糞便微生物移植治療についてのオミックス解析(Omics analysis in fecal transplantation therapy for Clostridioides difficile infection)

    阪口 義彦, 後藤 和義, 妹尾 充敏, 武 晃, 内山 淳平, 尾崎 隼人, 城代 康貴, 林 俊治, 大宮 直木, 加藤 はる

    日本細菌学雑誌   75 ( 1 )   125 - 125   2020.1

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  • Clostridioides difficile感染症に対する糞便微生物移植治療についてのオミックス解析(Omics analysis in fecal transplantation therapy for Clostridioides difficile infection)

    阪口 義彦, 後藤 和義, 妹尾 充敏, 武 晃, 内山 淳平, 尾崎 隼人, 城代 康貴, 林 俊治, 大宮 直木, 加藤 はる

    日本細菌学雑誌   75 ( 1 )   125 - 125   2020.1

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  • 牛白血病ウイルス感染による乳牛の腸内細菌叢の解析

    内山 淳平, 村上 裕信, 佐藤 礼一郎, 水上 圭二郎, 鈴木 武人, 島 綾香, 石原 玄基, 阪口 義彦, 曽川 一幸, 阪口 雅弘

    日本細菌学雑誌   75 ( 1 )   126 - 126   2020.1

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  • アトピー性皮膚炎犬におけるワクチン副反応リスクの検討

    杉本 良輔, 島倉 秀勝, 内山 淳平, 津久井 利広, 藤村 正人, 阪口 雅弘

    日本細菌学雑誌   75 ( 1 )   97 - 97   2020.1

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  • 組換えendolysinのブドウ球菌に対する溶菌作用ならびに膿痂疹モデルマウスにおける発症抑制効果

    今西 市朗, 内山 淳平, 津久井 利広, 久恒 順三, 井手 香織, 松崎 茂展, 菅井 基行, 西藤 公司

    日本細菌学雑誌   75 ( 1 )   97 - 97   2020.1

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  • イヌの純血コロニーを利用したアトピー性皮膚炎に関連した口腔・腸内細菌叢の解析

    海野 朝香, 今西 市朗, 水上 圭二郎, 大隅 尊史, 五十嵐 寛高, 村上 裕信, 島 綾香, 宇根 有美, 阪口 雅弘, 内山 淳平

    日本細菌学雑誌   75 ( 1 )   76 - 76   2020.1

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  • アトピー性皮膚炎犬におけるワクチン副反応リスクの検討

    杉本 良輔, 島倉 秀勝, 内山 淳平, 津久井 利広, 藤村 正人, 阪口 雅弘

    日本細菌学雑誌   75 ( 1 )   97 - 97   2020.1

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  • グラム陽性細菌が産生する膜小胞の精製法の検討

    那須川 忠弥, 杉本 良輔, 島倉 秀勝, 小方 雅也, 福田 憲, 松崎 茂展, 内山 淳平

    日本細菌学雑誌   75 ( 1 )   73 - 73   2020.1

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  • イヌの純血コロニーを利用したアトピー性皮膚炎に関連した口腔・腸内細菌叢の解析

    海野 朝香, 今西 市朗, 水上 圭二郎, 大隅 尊史, 五十嵐 寛高, 村上 裕信, 島 綾香, 宇根 有美, 阪口 雅弘, 内山 淳平

    日本細菌学雑誌   75 ( 1 )   76 - 76   2020.1

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  • イヌにおけるアトピー性皮膚炎病態に関与するStaphylococcus pseudintermedius分子の探索

    島倉 秀勝, 鶴井 大幹, 坂本 修士, 樋口 琢磨, 伊從 慶太, 下池 健太, 阪口 雅弘, 内山 淳平

    日本細菌学雑誌   75 ( 1 )   157 - 157   2020.1

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  • 複数の獣医系機関におけるイヌの膿皮症やアレルギー性皮膚炎に対する抗菌薬非依存的な取り組み

    内山淳平, 今西市朗, 今西市朗, 西藤公司, 福山朋季, 伊從慶太, 津久井利広, 阪口雅弘

    日本ブドウ球菌研究会プログラム・講演要旨集   65th (Web)   2020

  • Analysis of gut microbiome in dairy cows infected with bovine leukemia virus

    内山淳平, 村上裕信, 佐藤礼一郎, 水上圭二郎, 鈴木武人, 島綾香, 石原玄基, 阪口義彦, 阪口義彦, 曽川一幸, 阪口雅弘

    日本細菌学雑誌(Web)   75 ( 1 )   2020

  • 牛伝染性リンパ腫ウイルス感染による乳牛の腸内細菌叢への影響

    内山淳平, 村上裕信, 佐藤礼一郎, 水上圭二郎, 鈴木武人, 島綾香, 石原玄基, 曽川一幸, 阪口雅弘

    日本ワンヘルスサイエンス学会年次学術集会抄録集(Web)   4th   2020

  • Analysis of oral and gut microbiome associated with atopic dermatitis, using purebred dog colony

    海野朝香, 今西市朗, 水上圭二郎, 大隅尊史, 五十嵐寛高, 村上裕信, 島綾香, 宇根有美, 阪口雅弘, 内山淳平

    日本細菌学雑誌(Web)   75 ( 1 )   2020

  • Therapeutic potential of an endolysin derived from bacteriophage S25-3 for Staphylococcal impetigo

    今西市朗, 内山淳平, 津久井利広, 久恒順三, 井手香織, 松崎茂展, 菅井基行, 西藤公司

    日本細菌学雑誌(Web)   75 ( 1 )   2020

  • バクテリオファージを利用した高選択的な細菌検出技術の開発

    今井斉志, 仁子陽輔, 波多野慎悟, 渡辺茂, 内山伊代, 内山淳平, 松崎茂展

    日本分析化学会年会講演要旨集(Web)   69th   324 - 324   2020

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  • ネコ用ワクチン接種後のアナフィラキシーに関する研究

    吉田愛美, 吉田愛美, 伊藤雅人, 水上圭二郎, 水上圭二郎, 内山淳平, 阪口雅弘

    日本ワンヘルスサイエンス学会年次学術集会抄録集(Web)   4th   2020

  • Search for Staphylococcus pseudintermedius molecule associated with atopic dermatitis in dogs.

    島倉秀勝, 島倉秀勝, 鶴井大幹, 坂本修士, 樋口琢磨, 伊從慶太, 下池健太, 阪口雅弘, 内山淳平

    日本細菌学雑誌(Web)   75 ( 1 )   2020

  • Examination of adverse reaction risk to vaccine in atopic dermatitis dogs.

    杉本良輔, 島倉秀勝, 内山淳平, 津久井利広, 藤村正人, 阪口雅弘

    日本細菌学雑誌(Web)   75 ( 1 )   2020

  • Examination of the purification method of the membrane vesicles produced by Gram-positive bacteria

    那須川忠弥, 杉本良輔, 島倉秀勝, 小方雅也, 福田憲, 松崎茂展, 内山淳平

    日本細菌学雑誌(Web)   75 ( 1 )   2020

  • Omics analysis in fecal transplantation therapy for Clostridioides difficile infection

    阪口義彦, 後藤和義, 妹尾充敏, 武晃, 内山淳平, 尾崎隼人, 城代康貴, 林俊治, 大宮直木, 加藤はる

    日本細菌学雑誌(Web)   75 ( 1 )   2020

  • Development of a reagent to increase accuracy of GBS screening test for pregnant women

    小方雅也, 内山淳平, 松井秀仁, 内山伊代, 那須川忠弥, 松崎茂展, 花木秀明, 阪口雅弘

    日本細菌学雑誌(Web)   75 ( 1 )   2020

  • 新規神経細胞保護物質の探索及び作用機構解析

    鶴川 幸音, 菅野 和紀, 鈴木 優華, 村上 裕信, 内山 淳平, 竹田 志郎, 永根 大幹, 坂上 元栄, 紙透 伸治

    日本獣医学会学術集会講演要旨集   162回   485 - 485   2019.8

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  • 加齢によるイヌの腸内細菌叢の変化

    水上 圭二郎, 内山 淳平, 五十嵐 寛高, 村上 裕信, 大隅 尊史, 島 綾香, 石原 玄基, 那須川 忠弥, 宇根 有美, 阪口 雅弘

    日本獣医学会学術集会講演要旨集   162回   369 - 369   2019.8

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  • Current state of microbiome knowledge in dogs and cats Invited Reviewed

    五十嵐寛高, 内山淳平, 根尾櫻子, 村上裕信, 福山朋季, 久末正晴, 阪口雅弘

    月刊Precision Medicine   2 ( 4 )   373 - 377   2019.4

  • 一般遠心機を使用してウイルスを精製する

    那須川忠弥, 内山淳平, 田原口智士, 松崎茂展, 阪口雅弘

    麻布大学雑誌(Web)   30 ( 30 )   84 - 84   2019.3

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  • Clostridioides difficile感染症に対する糞便移植療法における腸管細菌叢と代謝産物の分析(Analysis of gut microbiota and metabolite in fecal transplantation therapy for Clostridioides difficile infection)

    阪口 義彦, 後藤 和義, 妹尾 充敏, 内山 淳平, 尾崎 隼人, 城代 康貴, 林 俊治, 大宮 直木, 加藤 はる

    日本細菌学雑誌   74 ( 1 )   109 - 109   2019.3

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  • B群連鎖球菌検査におけるファージ溶菌酵素の利用の可能性

    小方 雅也, 内山 淳平, 松井 秀仁, 松崎 茂展, 花木 秀明

    感染症学雑誌   93 ( 臨増 )   387 - 387   2019.3

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  • グループB連鎖球菌感染症の出生前スクリーニング法のファージを用いた改善可能性(Potential improvement of prenatal Group B Streptococcus screening using phages)

    内山 淳平, 松井 秀仁, 那須川 忠弥, 阪口 義彦, 水上 圭二郎, 阪口 雅弘, 松崎 茂展, 花木 秀明

    日本細菌学雑誌   74 ( 1 )   66 - 66   2019.3

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  • 犬アトピー性皮膚炎を悪化させるStaphylococcus pseudintermedius分子の探索

    那須川 忠弥, 内山 淳平, 鶴井 大幹, 坂本 修士, 樋口 琢磨, 伊從 慶太, 下池 健太, 島倉 秀勝, 松崎 茂展, 阪口 雅弘

    日本細菌学雑誌   74 ( 1 )   140 - 140   2019.3

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  • B群連鎖球菌検査におけるファージ溶菌酵素の利用の可能性

    小方雅也, 内山淳平, 松井秀仁, 松崎茂展, 花木秀明

    感染症学雑誌   93 ( 臨増 )   387 - 387   2019.3

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  • ロボショットにおけるIoTへの対応—Roboshot's Response to IoT—特集 新しいモノづくりへの挑戦

    内山 辰宏, 内山 淳平, 浅岡 裕泰

    プラスチックスエージ = Plastics age   65 ( 1 )   62 - 67   2019.1

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  • 純血種犬コロニーを用いた腸内細菌叢の加齢性変化の同定

    水上圭二郎, 水上圭二郎, 内山淳平, 五十嵐寛高, 村上裕信, 大隅尊史, 島綾香, 島綾香, 石原玄基, 那須川忠弥, 宇根有美, 宇根有美, 阪口雅弘

    日本ワンヘルスサイエンス学会年次学術集会抄録集(Web)   3rd   2019

  • Analysis of gut microbiota and metabolite in fecal transplantation therapy for Clostridioides difficile infection

    阪口義彦, 後藤和義, 妹尾充敏, 内山淳平, 尾崎隼人, 城代康貴, 林俊治, 大宮直木, 加藤はる

    日本細菌学雑誌(Web)   74 ( 1 )   2019

  • Search for Staphylococcus pseudintermedius molecules exacerbating canine atopic dermatitis

    那須川忠弥, 内山淳平, 鶴井大幹, 坂本修士, 樋口琢磨, 伊從慶太, 下池健太, 島倉秀勝, 松崎茂展, 阪口雅弘

    日本細菌学雑誌(Web)   74 ( 1 )   2019

  • イヌの狂犬病ワクチン接種後のアナフィラキシーに関する研究

    吉田愛美, 伊藤雅人, 楠見夏樹, 水上圭二郎, 水上圭二郎, 内山淳平, 阪口雅弘

    日本ワンヘルスサイエンス学会年次学術集会抄録集(Web)   3rd   2019

  • イヌの混合ワクチン接種後アナフィラキシーに関する研究:ヒトの予防接種後副反応の標準化症例定義(Brighton分類)の応用

    伊藤雅人, 水上圭二郎, 水上圭二郎, 内山淳平, 阪口雅弘

    日本ワンヘルスサイエンス学会年次学術集会抄録集(Web)   3rd   2019

  • バンコマイシン耐性腸球菌眼内炎に対するファージ療法の効果

    岸本達真, 中島勇魚, 石田わか, 鈴木崇, 内山淳平, 松崎茂展, 大畑雅典, 福田憲, 福島敦樹

    日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集   56th-53rd-62nd-8th   2019

  • 出産前B群連鎖球菌培養検査における検査精度向上のためのファージ利用の可能性

    内山 淳平, 松井 秀仁, 花木 秀明

    日本臨床微生物学会雑誌   29 ( Suppl.1 )   368 - 368   2018.12

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  • Pestalotiopsis microsporaが生産する神経細胞保護活性物質の単離と構造決定

    菅野和紀, 鶴川幸音, 柴崎久宣, 村上裕信, 内山淳平, 倉持幸司, 紙透伸治

    日本農芸化学会関東支部講演要旨集   2018 ( Oct )   18   2018.10

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  • ウイルスの系統とゲノム組換え―Earth’s viromeデータの解析から― Invited International journal

    矢原耕史, MEIER‐KOLTHOFF Jan P, 内山淳平, 矢原寛子, PAEZ‐ESPINO David

    日本進化学会大会プログラム・講演要旨集(Web)   20th ( 1 )   87 (WEB ONLY) - 11496   2018.8

  • 牛白血病ウイルス野外株の遺伝的多様性と病原性への影響

    村上裕信, 河合将克, 佐籐礼一郎, 前田洋佑, 加藤肇, 内山淳平, 阪口雅弘, 塚本健司

    日本獣医学会学術集会講演要旨集   161回   352 - 352   2018.8

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  • 臨床皮膚科でいま“できる”ことを提案する 第3回 膿皮症アップデート―夏の強敵と対峙する!―CCG6 メチシリン耐性ブドウ球菌の同定

    内山淳平

    Small Animal Dermatology   14 ( 4 )   19‐25 - 25   2018.7

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  • 動物における「マイクロバイオーム」研究の現状と応用 マイクロバイオーム解析の基礎 細菌叢解析を中心に Invited

    内山 淳平

    ペット栄養学会誌   21 ( 2 )   S11 - S11   2018.7

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  • 【臨床皮膚科でいま"できる"ことを提案する 第3回 膿皮症アップデート-夏の強敵と対峙する!-】 ヒトの医療におけるメチシリン耐性黄色ブドウ球菌の除菌

    内山 淳平

    Small Animal Dermatology   14 ( 4 )   34 - 35   2018.7

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  • 臨床皮膚科でいま“できる”ことを提案する 第3回 膿皮症アップデート―夏の強敵と対峙する!―CCG10 ヒトの医療におけるメチシリン耐性黄色ブドウ球菌の除菌

    内山淳平

    Small Animal Dermatology   14 ( 4 )   34 - 35   2018.7

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  • CCG6 メチシリン耐性ブドウ球菌の同定 (特集 臨床皮膚科でいま"できる"ことを提案する(第3回)膿皮症アップデート 夏の強敵と対峙する!)

    内山 淳平

    Small animal dermatology : 小動物皮膚科専門誌   52 ( 4 )   19 - 25   2018.7

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    Other Link: http://search.jamas.or.jp/link/ui/2018300752

  • バクテリオファージを利用する多剤耐性細菌感染症制御法 Invited Reviewed

    松﨑茂展, 内山淳平

    動物用ワクチン・バイオ医薬品研究会 NEWSletter   17 ( 17 )   11 - 16   2018.6

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  • バクテリオファージ担持金ナノ粒子凝集体を利用した細菌の暗視野顕微鏡検出

    今井斉志, 鷲尾和也, 仁子陽輔, 波多野慎悟, 渡辺茂, 松崎茂展, 内山淳平

    日本化学会春季年会講演予稿集(CD-ROM)   98th   ROMBUNNO.3G3‐02   2018.3

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  • C型とD型ボツリヌス毒素変換ファージの解析(Analysis of botulinum neurotoxin-converting phages in Clostridium botulinum types C and D)

    阪口 義彦, 内山 淳平, 小椋 義俊, 後藤 和義, 山本 由弥子, 松崎 茂展, 山口 明日美, 林 哲也, 小熊 惠二, 林 俊治

    日本細菌学雑誌   73 ( 1 )   94 - 94   2018.2

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  • C型とD型ボツリヌス毒素変換ファージの解析(Analysis of botulinum neurotoxin-converting phages in Clostridium botulinum types C and D)

    阪口 義彦, 内山 淳平, 小椋 義俊, 後藤 和義, 山本 由弥子, 松崎 茂展, 山口 明日美, 林 哲也, 小熊 惠二, 林 俊治

    日本細菌学雑誌   73 ( 1 )   94 - 94   2018.2

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  • Acinetobacter baumanniiの同定方法の比較検討

    山口 明日美, 阪口 義彦, 松井 真理, 内山 淳平, 松井 秀仁, 花木 秀明, 小林 秀丈, 小山内 洋子, 林 俊治

    日本細菌学雑誌   73 ( 1 )   66 - 66   2018.2

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  • 関東の医療施設で分離されたAcinetobacter baumanniiの分子疫学的解析

    山口 明日美, 阪口 義彦, 松井 真理, 小林 秀丈, 内山 淳平, 小山内 洋子, 松井 秀仁, 花木 秀明, 林 俊治

    日本細菌学雑誌   73 ( 1 )   52 - 52   2018.2

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  • 関東の医療施設で分離されたAcinetobacter baumanniiの分子疫学的解析

    山口 明日美, 阪口 義彦, 松井 真理, 小林 秀丈, 内山 淳平, 小山内 洋子, 松井 秀仁, 花木 秀明, 林 俊治

    日本細菌学雑誌   73 ( 1 )   52 - 52   2018.2

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  • Acinetobacter baumanniiの同定方法の比較検討

    山口 明日美, 阪口 義彦, 松井 真理, 内山 淳平, 松井 秀仁, 花木 秀明, 小林 秀丈, 小山内 洋子, 林 俊治

    日本細菌学雑誌   73 ( 1 )   66 - 66   2018.2

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  • 関東の医療施設で分離されたAcinetobacter baumanniiの分子疫学的解析

    山口明日美, 阪口義彦, 松井真理, 小林秀丈, 内山淳平, 小山内洋子, 松井秀仁, 花木秀明, 林俊治

    日本細菌学雑誌(Web)   73 ( 1 )   2018

  • Introduction to gut microflora analysis

    Uchiyama Jumpei

    Journal of Pet Animal Nutrition   21 ( 3 )   142 - 144   2018

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    DOI: 10.11266/jpan.21.3_142

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  • 腸球菌眼内炎に対するバクテリオファージ療法の効果

    岸本達真, 石田わか, 鈴木崇, 内山淳平, 松崎茂展, 大畑雅典, 福田憲, 福島敦樹

    日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集   55th-52nd-61st-7th   69   2018

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  • 外側半月板水平断裂に伴う嚢腫に対して半月板縫合術を施行した1例

    多和田兼章, 山田邦雄, 室秀紀, 星野啓介, 戸野祐二, 舩橋伸司, 五十棲秀幸, 井上淳平, 大野木宏洋, 内山田修一, 加藤治朗, 野崎正浩

    中部リウマチ   48 ( 1 )   2018

  • 当院におけるM2a-Magnum metal on metal人工股関節置換術の中期成績

    和田兼章, 山田邦雄, 室秀紀, 星野啓介, 戸野祐二, 舩橋伸司, 五十棲秀幸, 井上淳平, 大野木宏洋, 内山田修一, 加藤治朗

    中部リウマチ   48 ( 1 )   2018

  • Acinetobacter baumanniiのresistance islandの遺伝子解析

    山口 明日美, 松井 真理, 内山 淳平, 松井 秀仁, 花木 秀明, 林 俊治, 阪口 義彦, 小山内 洋子, 小林 秀丈

    日本臨床微生物学雑誌   28 ( Suppl.1 )   490 - 490   2017.12

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  • Acinetobacter baumanniiのresistance islandの遺伝子解析

    山口 明日美, 松井 真理, 内山 淳平, 松井 秀仁, 花木 秀明, 林 俊治, 阪口 義彦, 小山内 洋子, 小林 秀丈

    日本臨床微生物学雑誌   28 ( Suppl.1 )   490 - 490   2017.12

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  • Acinetobacter baumanniiの同定方法の比較検討

    山口 明日美, 阪口 義彦, 小山内 洋子, 林 俊治, 松井 秀仁, 花木 秀明, 松井 真理, 内山 淳平

    首都圏支部・関甲信支部医学検査学会プログラム・講演抄録集   54回 ( 1 )   150 - 150   2017.10

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  • クライオ電子顕微鏡を用いた単粒子解析による近原子分解能での黄色ブドウ球菌ファージS13'の頭部構造(The head structure of the Staphylococcus aureus phage S13' at near atomic resolution by cryo-electron microscopy single particle analysis)

    Miyazaki Naoyuki, Uchiyama Jumpei, Matsuzaki Shigenobu, Murata Kazuyoshi, Iwasaki Kenji

    生物物理   57 ( Suppl.1-2 )   S236 - S236   2017.8

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  • 【視野を広げる皮膚科診療のTips(秘訣)第10回 皮膚科のお悩み相談室】膿皮症 膿皮症の診断・治療に際して、なかなか細菌検査を実施することができません。検査の重要性、実施法や検査機関の選択などを教えてください

    内山 淳平, 阪口 雅弘, 加藤 行男, 伊從 慶太

    Small Animal Dermatology   13 ( 4 )   17 - 26   2017.7

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  • 視野を広げる皮膚科診療のTips(秘訣)第10回 皮膚科の“お悩み”相談室 II・膿皮症 Q6 膿皮症の診断・治療に際して,なかなか細菌検査を実施することができません。検査の重要性,実施法や検査機関の選択などを教えてください。

    内山淳平, 阪口雅弘, 加藤行男, 伊從慶太

    Small Animal Dermatology   46 ( 4 )   17 - 26   2017.7

  • Q 膿皮症の診断・治療に際して,なかなか細菌検査を実施することができません。検査の重要性,実施法や検査機関の選択などを教えてください。 (特集 視野を広げる皮膚科診療のTips(秘訣)(第10回)皮膚科の"お悩み"相談室) -- (膿皮症)

    内山 淳平, 阪口 雅弘, 加藤 行男, 伊從 慶太

    Small animal dermatology : 小動物皮膚科専門誌   46   17 - 26   2017.7

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  • 組換えendolysinのブドウ球菌に対する溶菌作用ならびに膿痂疹モデルマウスにおける発症抑制効果

    今西市朗, 内山淳平, 水谷歩実, 井手香織, 西藤公司

    日本獣医皮膚科学会学術大会・総会   20th   88   2017.3

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  • バクテリオファージKHP30の感染能に及ぼすピロリ菌保有制限 修飾系の解析

    松澤 佑一, 内山 淳平, 竹内 啓晃, 氏原 隆子, 橋田 裕美子, 樋口 智紀, 田中 望紅, 冨永 宗一竜, 大畑 雅典, 松崎 茂展

    日本細菌学雑誌   72 ( 1 )   95 - 95   2017.2

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  • 黄色ブドウ球菌に感染するAHJD様ファージの吸着に関する研究(Study of adsorption of AHJD-like phages infecting Staphylococcus aureus)

    内山 淳平, 黒川 健児, 内山 伊代, 氏原 隆子, 阪口 義彦, 松崎 茂展, 阪口 雅弘

    日本細菌学雑誌   72 ( 1 )   169 - 169   2017.2

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  • バクテリオファージKHP30の感染能に及ぼすピロリ菌保有制限 修飾系の解析

    松澤 佑一, 内山 淳平, 竹内 啓晃, 氏原 隆子, 橋田 裕美子, 樋口 智紀, 田中 望紅, 冨永 宗一竜, 大畑 雅典, 松崎 茂展

    日本細菌学雑誌   72 ( 1 )   95 - 95   2017.2

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  • B6型ボツリヌス毒素遺伝子をコードするプラスミドの解析(Analysis of botulinum neurotoxin type B6 gene-encoding plasmid in Clostridium botulinum type B)

    阪口 義彦, 内山 淳平, 細見 晃司, 幸田 知子, 小椋 義俊, 林 哲也, 林 俊治, 小崎 俊司, 向本 雅郁

    日本細菌学雑誌   72 ( 1 )   127 - 127   2017.2

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  • B6型ボツリヌス毒素遺伝子をコードするプラスミドの解析(Analysis of botulinum neurotoxin type B6 gene-encoding plasmid in Clostridium botulinum type B)

    阪口 義彦, 内山 淳平, 細見 晃司, 幸田 知子, 小椋 義俊, 林 哲也, 林 俊治, 小崎 俊司, 向本 雅郁

    日本細菌学雑誌   72 ( 1 )   127 - 127   2017.2

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  • 黄色ブドウ球菌に感染するAHJD様ファージの吸着に関する研究(Study of adsorption of AHJD-like phages infecting Staphylococcus aureus)

    内山 淳平, 黒川 健児, 内山 伊代, 氏原 隆子, 阪口 義彦, 松崎 茂展, 阪口 雅弘

    日本細菌学雑誌   72 ( 1 )   169 - 169   2017.2

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  • Development of Operation Detection System of Check Ring in Injection Molding Machine

    TAKATSUGI Satoshi, UCHIYAMA Tatsuhiro, MARUYAMA Jyunpei, ISHIKURO Toshio, FUJIOKA Osamu, OHMORI Akira

    Journal of the Japan Society for Precision Engineering   83 ( 3 )   281 - 286   2017

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    The authors propose a new method of detecting the operations of a check ring by employing the torque load T in the reverse direction of rotation applied during injection at the servo motor for rotating the screw equipped to electric injection molding machines. Through experiments, the authors confirmed that the torque load T peak and ring closing timing match, and that there exists a clear negative correlation between the T time integral value Bf and molded product weight. In addition, check rings with different closing strokes S and external diameters D were used to investigate the correlations between the closing stroke/external diameter and Bf, and it was found that the larger S is, the greater is Bf, and that Bf increases suddenly as D decreases (interval with the cylinder increases). The torque load of the injection molding machine was monitored using the developed check ring operations detection method based on these results, and it was demonstrated that reverse flow amount can constantly be monitored with this method. These findings suggest that the developed method is useful for predicting the life of check rings.

    DOI: 10.2493/jjspe.83.281

    DOI: 10.2493/jjspe.83.613_references_DOI_JivvmCqDxPjGPYP6OHPLqMWhDPr

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  • Development of Method for Injecting Stable Resin Amount in Injection Molding Machine

    TAKATSUGI Satoshi, UCHIYAMA Tatsuhiro, MARUYAMA Jyunpei, ISHIKURO Toshio, FUJIOKA Osamu, OHMORI Akira

    Journal of the Japan Society for Precision Engineering   83 ( 6 )   613 - 618   2017

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    In this study, a method to facilitate the check ring closing motion by reversing or advancing the screw after the metering process was proposed for the purpose of stabilizing the injection amount of resin. Experiments were conducted on the proposed method, and it was confirmed that rotating the screw in the reverse direction resulted in good closing efficiency in the plastication of PBT, but the check ring did not completely close even when the screw was rotated in the reverse direction in the plastication of low viscosity PC. On the other hand, advancing the screw in the normal direction was found to be effective for improving the check ring closing motion and suppressing backflow in the plastication of PBT and PC. It was also confirmed that these effects are further increased when screw advancement and rotation are both performed. Furthermore, it was indicated that backflow estimation by detecting screw rotating motor load was a useful tool for optimally setting the screw reverse rotation angle when reversing screw rotation and the compression pressure when advancing the screw. Variation of the weight of the molded part was evaluated, and it was confirmed that the stability of resin injection improved remarkably with this stabilization method compared to the standard injection method without screw reverse rotation or advancement.

    DOI: 10.2493/jjspe.83.613

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  • バクテリオファージKHP30の感染能に及ぼすピロリ菌保有制限-修飾系の解析

    松澤佑一, 内山淳平, 竹内啓晃, 氏原隆子, 橋田裕美子, 樋口智紀, 田中望紅, 冨永宗一竜, 大畑雅典, 松崎茂展

    日本細菌学雑誌(Web)   72 ( 1 )   2017

  • 内側半月板再断裂に対してフィブリンクロットを用いて再縫合を行った1例

    多和田兼章, 山田邦雄, 室秀紀, 星野啓介, 戸野祐二, 舩橋伸司, 福田誠, 五十棲秀幸, 井上淳平, 内山田修一, 加藤治朗, 野崎正浩

    中部リウマチ   47 ( 1 )   2017

  • 42mm大径骨頭metal on metal人工股関節置換術後に生じた偽腫瘍の1例

    多和田兼章, 山田邦雄, 室秀紀, 星野啓介, 戸野祐二, 舩橋伸司, 福田誠, 五十棲秀幸, 井上淳平, 内山田修一, 加藤治朗

    中部リウマチ   47 ( 1 )   2017

  • Helicobacter pylori ファージとそのゲノム (特集 Helicobacter pyloriのゲノムサイエンス)

    内山 淳平, 竹内 啓晃, 平山 隆一郎, 島倉 秀勝, 阪口 雅弘, 松崎 茂展

    Helicobacter research : Journal of helicobacter research   20 ( 5 )   470 - 474   2016.10

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  • Helicobacterのゲノムサイエンス Helicobacter pyloriファージとそのゲノム

    内山淳平, 竹内啓晃, 平山隆一郎, 島倉秀勝, 阪口雅弘, 松崎茂展

    Helicobacter Research   20 ( 5 )   470 - 474   2016.10

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  • ファージ・ルネッサンス ファージ発見から100年たった今 活性型ピロリ菌ファージKHP30の特徴付けとその潜伏感染性の解析(Phage renaissance: 100 years have passed since phage discovery Characterization of active Helicobacter pylori phage KHP30, and analysis of its latent infection)

    内山 淳平, 内山 伊代, 竹内 啓晃, 阪口 義彦, 阪口 雅弘, 松崎 茂展

    日本細菌学雑誌   71 ( 1 )   53 - 53   2016.2

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  • C型ボツリヌス毒素変換ファージのゲノム比較と遺伝子機能解析(The genome sequence of Clostridium botulinum type C phage and functional analysis of gene products)

    阪口 義彦, 内山 淳平, 小椋 義俊, 山本 由弥子, 松崎 茂展, 林 哲也, 松下 治, 小熊 惠二, 林 俊治

    日本細菌学雑誌   71 ( 1 )   135 - 135   2016.2

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  • ファージ・ルネッサンス ファージ発見から100年たった今 ファージを利用した細菌検出 黄色ブドウ球菌検出ファージクロマト法の開発

    松井 秀仁, 内山 淳平, 津田 愛美, 松崎 茂展, 花木 秀明

    日本細菌学雑誌   71 ( 1 )   54 - 54   2016.2

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  • 緑膿菌PAO1株とファージKPP22の短期間進化的軍拡競走の解析

    那須川 忠弥, 内山 淳平, 鈴木 仁人, 宮田 玲奈, 山口 琴絵, 内山 伊代, 阪口 義彦, 柴山 恵吾, 阪口 雅弘, 松崎 茂展

    日本細菌学雑誌   71 ( 1 )   92 - 92   2016.2

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  • Helicobacter pylori ファージとそのゲノム

    内山 淳平, 竹内 啓晃, 松崎 茂展

    Helicobacter Research   20   50 - 54   2016

  • Machining Speed of Small Curved Holes using Electrochemical Machining

    UCHIYAMA Mitsuo, KUROSAWA Keita, SUZUKI Junpei

    Journal of The Japan Society of Electrical Machining Engineers   50 ( 123 )   36 - 42   2016

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    This paper describes the design optimization of the structure of a tool for producing curved holes by electrochemical machining and the results of machining experiments. Curved holes can be machined using a flexible tool that can be curved by the hole being processed by the tool itself. The tool for producing small holes of less than 6 mm diameter has a simple structure composed of a flexible tube and a columnar electrode tip. A tool device equipped with an ultrasonic vibration function was designed and fabricated to remove the sludge from the curved face of the hole during machining. Machining tests showed that the machining speed was able to exceed the target value of 1mm/min.

    DOI: 10.2526/jseme.50.36

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  • 細菌感染症における診断法と治療法の開発:バクテリオファージの利用

    内山淳平, 松井秀仁, 阪口義彦, 花木秀明, 松崎茂展, 阪口雅弘

    日本獣医学会学術集会講演要旨集   158回   182 - 182   2015.8

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  • イヌにおける新規口腔内常在細菌の同定と全ゲノム配列解析

    平山隆一郎, 平山隆一郎, 鈴木仁人, 内山淳平, 松井真理, 鈴木里和, 柴山恵吾, 阪口雅弘, 木内明男

    日本獣医学会学術集会講演要旨集   158回   313 - 313   2015.8

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  • 眼感染症に対するファージ療法の研究開発および臨床応用への問題点

    福田憲, 石田わか, 内山淳平, 松崎茂展, 福島敦樹

    日本獣医学会学術集会講演要旨集   158回   183 - 183   2015.8

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  • 食物有害反応を示す犬における卵白アレルゲンに対するIgE反応性の検討

    島倉秀勝, 齋藤拓, 藤村正人, 岡本憲明, 内山淳平, 阪口雅弘

    日本獣医学会学術集会講演要旨集   158回   401 - 401   2015.8

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  • Evaluation of the lubrication mechanism at various rotation speeds and granule filling levels in a container mixer using a thermal effusivity sensor Reviewed International journal

    Jumpei Uchiyama, Shigeru Aoki

    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY   41 ( 7 )   1172 - 1181   2015.7

  • ファージ尾部タンパクを用いた黄色ブドウ球菌検出方法の開発

    松井 秀仁, 崔 龍洙, 花木 秀明, 内山 淳平, 松崎 茂展

    日本化学療法学会雑誌   63 ( Suppl.A )   170 - 170   2015.5

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  • New Approach to Evaluate the Lubrication Process in Various Granule Filling Levels and Rotating Mixer Sizes Using a Thermal Effusivity Sensor Reviewed

    Jumpei Uchiyama, Shigeru Aoki, Yoshifumi Uemoto

    CHEMICAL & PHARMACEUTICAL BULLETIN   63 ( 3 )   164 - 179   2015.3

  • B型ボツリヌス菌のボツリヌス毒素遺伝子をコードするプラスミド解析(Analysis of botulinum neurotoxin type B6 gene-encoding plasmid in Clostridium botulinum type B)

    阪口 義彦, 内山 淳平, 細見 晃司, 幸田 知子, 松崎 茂展, 小椋 義俊, 林 哲也, 林 俊治, 小崎 俊司, 向本 雅郁

    日本細菌学雑誌   70 ( 1 )   178 - 178   2015.2

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  • 各種ファージに対する黄色ブドウ球菌受容体の解析

    内山淳平, 黒川健児, 坂口義彦, 内山(竹村)伊代, 氏原隆子, 村上雅尚, 大畑雅典, 松崎茂展

    日本細菌学雑誌   70 ( 1 )   215 - 215   2015.2

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  • 緑膿菌感染症に対するファージ療法と化学療法の併用療法の可能性検討

    重久立, 内山淳平, 宮田怜奈, 山口琴絵, 内山伊代, 阪口義彦, 氏原隆子, 大畑雅典, 松崎茂展

    日本細菌学雑誌   70 ( 1 )   198 - 198   2015.2

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  • クライオ電子顕微鏡による新規大型黄色ブドウ球菌バクテリオファージS6の構造解析

    宮崎直幸, 内山淳平, 松崎茂展, 村田和義

    日本生化学会大会(Web)   87回   [2P - 130]   2014.10

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  • Genomic and phylogenetic traits of Staphylococcus phages S25-3 and S25-4 (family Myoviridae, genus Twort-like viruses) Reviewed

    Iyo Takemura-Uchiyama, Jumpei Uchiyama, Shin Ichiro Kato, Takako Ujihara, Masanori Daibata, Shigenobu Matsuzaki

    Annals of Microbiology   64 ( 3 )   1453 - 1456   2014.9

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  • 最先端医療・福祉の科学 ファージ吸着分子を利用した簡易迅速細菌検出技術

    内山淳平, 松井秀仁, 内山(竹村)伊代, 渡辺茂, 花木秀明, 松崎茂展

    化学工業   65 ( 8 )   588 - 595   2014.8

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  • Bacteria Detection Technology Using Phage Molecule

    内山 淳平, 松井 秀仁, 内山(竹村) 伊代

    化學工業   65 ( 8 )   588 - 595   2014.8

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  • ファージ吸着分子を利用した簡易迅速細菌検査技術 Invited

    内山淳平, 松井秀仁, 内山(竹村)伊代, 渡辺茂, 花木秀明, 松﨑茂展

    化学工業   65 ( 8 )   12 - 19   2014.8

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  • Evaluation of risk and benefit in thermal effusivity sensor for monitoring lubrication process in pharmaceutical product manufacturing Reviewed

    Jumpei Uchiyama, Yoshiteru Kato, Yoshifumi Uemoto

    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY   40 ( 8 )   999 - 1004   2014.8

  • ヒト正常肝および脂肪肝におけるオートファジーマーカータンパク質であるmicrotubule-associated protein 1 light chain 3の免疫組織化学的研究(Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers)

    Kashima Jumpei, Shintani-Ishida Kaori, Nakajima Makoto, Maeda Hideyuki, Unuma Kana, Uchiyama Yasuo, Yoshida Ken-ichi

    Hepatology Research   44 ( 7 )   779 - 787   2014.7

  • Development of new punch shape to replicate scale-up issues in laboratory tablet press II: a new design of punch head to emulate consolidation and dwell times in commercial tablet press. Reviewed International journal

    Shigeru Aoki, Jumpei Uchiyama, Manabu Ito

    Journal of pharmaceutical sciences   103 ( 6 )   1921 - 7   2014.6

  • Examination of generalized transduction among Staphylococcus spp., using a novel phage S6

    UCHIYAMA JUMPEI, TAKEMURA-UCHIYAMA IYO, SAKAGUCHI YOSHIHIKO, MISAWA NAOAKI, DAIBATA MASANORI, MATSUZAKI SHIGENOBU

    日本細菌学雑誌   69 ( 1 )   236 - 236   2014.2

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  • 緑膿菌ファージKPP21,KPP22,KPP23,KPP25の網羅的構造タンパク質解析

    重久立, 内山淳平, 宮田怜奈, 山口琴絵, 内山伊代, 氏原隆子, 大畑雅典, 松崎茂展

    日本細菌学雑誌   69 ( 1 )   139 - 139   2014.2

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  • 緑膿菌ファージKPP22吸着能変異ファージの解析

    宮田怜奈, 内山淳平, 山口琴絵, 重久立, 内山伊代, 氏原隆子, 大畑雅典, 松崎茂展

    日本細菌学雑誌   69 ( 1 )   138 - 138   2014.2

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  • Phage therapy experiment against staphylococcal lung-derived septic mouse model

    UCHIYAMA IYO, UCHIYAMA JUMPEI, SAKAGUCHI YOSHIHIKO, UJIHARA TAKAKO, DAIBATA MASANORI, MATSUZAKI SHIGENOBU

    日本細菌学雑誌   69 ( 1 )   139 - 139   2014.2

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  • 緑膿菌ファージの分離とそれらのゲノム塩基配列

    山口琴絵, 内山淳平, 宮田怜奈, 重久立, 内山伊代, 氏原隆子, 大畑雅典, 松崎茂展

    日本細菌学雑誌   69 ( 1 )   138 - 138   2014.2

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  • Estimation of Helicobacter pylori KHP30-like phage ecology

    MATSUZAKI SHIGENOBU, UCHIYAMA JUMPEI, TAKEUCHI HIROAKI, SAKAGUCHI YOSHIHIKO, UCHIYAMA-TAKEMURA IYO, UJIHARA TAKAKO, DAIBATA MASANORI

    日本細菌学雑誌   69 ( 1 )   237   2014.2

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  • ピロリ菌におけるKHP30様ファージの存在様式(Estimation of Helicobacter pylori KHP30-like phage ecology)

    松崎 茂展, 内山 淳平, 竹内 啓晃, 阪口 義彦, 内山 伊代[竹村], 氏原 隆子, 大畑 雅典

    日本細菌学雑誌   69 ( 1 )   237 - 237   2014.2

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  • Clostridium argentinenseにおけるG型ボツリヌス神経毒素遺伝子をコードするプラスミドの分析(Analysis of botulinum neurotoxin type G gene-encoding plasmid in Clostridium argentinense)

    阪口 義彦, 内山 淳平, 鈴木 智典, 山本 由弥子, 小椋 義俊, 細見 晃司, 松崎 茂展, 林 哲也, 小崎 俊司, 小熊 惠二

    日本細菌学雑誌   69 ( 1 )   236 - 236   2014.2

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  • Clostridium argentinenseにおけるG型ボツリヌス神経毒素遺伝子をコードするプラスミドの分析(Analysis of botulinum neurotoxin type G gene-encoding plasmid in Clostridium argentinense)

    阪口 義彦, 内山 淳平, 鈴木 智典, 山本 由弥子, 小椋 義俊, 細見 晃司, 松崎 茂展, 林 哲也, 小崎 俊司, 小熊 惠二

    日本細菌学雑誌   69 ( 1 )   236 - 236   2014.2

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  • 黄色ブドウ球菌性肺由来敗血症マウスモデルにおけるファージ療法の検討(Phage therapy experiment against staphylococcal lungderived septic mouse model)

    内山 伊代, 内山 淳平, 阪口 義彦, 氏原 隆子, 大畑 雅典, 松崎 茂展

    日本細菌学雑誌   69 ( 1 )   139 - 139   2014.2

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  • 新規ファージS6の分離とブドウ球菌における普遍形質導入の検討(Examination of generalized transduction among Staphylococcus spp., using a novel phage S6)

    内山 淳平, 内山 伊代, 阪口 義彦, 三澤 尚明, 大畑 雅典, 松崎 茂展

    日本細菌学雑誌   69 ( 1 )   236 - 236   2014.2

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  • A novel approach to a fine particle coating using porous spherical silica as core particles

    Ishida, M., Uchiyama, J., Isaji, K., Suzuki, Y., Ikematsu, Y., Aoki, S.

    Drug Development and Industrial Pharmacy   40 ( 8 )   1054 - 1064   2014.1

  • Development of new shaped punch to predict scale-up issue in tableting process. Reviewed International journal

    Shigeru Aoki, Jumpei Uchiyama, Manabu Ito

    Journal of pharmaceutical sciences   103 ( 1 )   235 - 40   2014.1

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  • Draft genome sequence of Clostridium botulinum type B strain Osaka05, isolated from an infant patient with botulism in Japan Reviewed

    Yoshihiko Sakaguchi, Koji Hosomi, Jumpei Uchiyama, Yoshitoshi Ogura, Kaoru Umeda, Masakiyo Sakaguchi, Tomoko Kohda, Masafumi Mukamoto, Naoaki Misawa, Shigenobu Matsuzaki, Tetsuya Hayashi, Shunji Kozaki

    Genome Announcements   2 ( 1 )   2014

  • Helicobacter pylori基礎研究の最前線 2.病原因子 Helicobacter pyloriのファージに関する基礎摘研究

    竹内啓晃, 内山淳平, 松崎茂展, 森本徳仁, 杉浦哲朗

    Helicobacter Res   17 ( 5 )   400 - 405   2013.10

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  • 【Helicobacter pylori基礎研究の最前線】 病原因子 Helicobacter pyloriのファージに関する基礎的研究

    竹内 啓晃, 内山 淳平, 松崎 茂展, 森本 徳仁, 杉浦 哲朗

    Helicobacter Research   17 ( 5 )   400 - 405   2013.10

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    Other Link: http://search.jamas.or.jp/link/ui/2014038434

  • Helicobacter pylori ファージに関する基礎的研究 Invited

    竹内啓晃, 内山淳平, 松﨑茂展, 森本徳仁, 杉浦哲朗

    Helicobacter Research   17 ( 5 )   28 - 33   2013.10

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  • Characterization of Helicobacter pylori Bacteriophage KHP30 Reviewed

    Jumpei Uchiyama, Hiroaki Takeuchi, Shin-ichiro Kato, Keiji Gamoh, Iyo Takemura-Uchiyama, Takako Ujihara, Masanori Daibata, Shigenobu Matsuzaki

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY   79 ( 10 )   3176 - 3184   2013.5

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    DOI: 10.1128/AEM.03530-12

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  • C型ボツリヌス毒素変換ファージのコアゲノムの探索

    阪口義彦, 内山淳平, 小椋義俊, 山本由弥子, 鈴木智典, 松崎茂展, 林哲也, 小熊惠二

    日本細菌学雑誌   68 ( 1 )   178 - 178   2013.2

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  • ピロリ菌バクテリオファージ(ファージ)KHP30の形態とゲノム解析

    内山淳平, 竹内啓晃, 阪口義彦, 氏原隆子, 内山伊代, 大畑雅典, 松崎茂展

    日本細菌学雑誌   68 ( 1 )   224 - 224   2013.2

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  • Bacteria Detection using Adsorption Protein of Tailed Phages

    内山 淳平, 内山(竹村) 伊代, 渡辺 茂

    Bio industry   30 ( 2 )   47 - 53   2013.2

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  • Synergistic bacteriolysis by bacteriophage $ϕ$EF24C endolysin ORF9 and lantibiotic nisin and its application to pulsed-field gel electrophoretic analysis of Enterococcus faecalis Reviewed

    Takemura-Uchiyama, Iyo, Uchiyama, Jumpei, Satoh, Miho, Ujihara, Takako, Daibata, Masanori, Matsuzaki, Shigenobu

    Annals of Microbiology   63 ( 3 )   1209 - 1211   2013

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    DOI: 10.1007/s13213-012-0556-y

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  • P182 Bacterial detection system for Staphylococcus aureus based on bacteriophage tail adsorption protein Reviewed

    Uchiyama, J, Uchiyama-Takemura, I, Watanabe, S, Sakaguchi, Y, Daibata, M, Matsuzaki, S

    International Journal of Antimicrobial Agents   42   S100 - S100   2013

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  • 黄色ブドウ球菌性肺感染症に対するファージ療法の可能性の検討

    松崎茂展, 内山淳平, 内山(竹村)伊代, 阪口義彦, 加藤伸一郎, 氏原隆子, 大畑雅典

    日本ブドウ球菌研究会プログラム・講演要旨集   58th   26   2013

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  • 新規ファージS6の分離とブドウ球菌における普遍形質導入の検討

    内山淳平, 内山(竹村)伊代, 蒲生恵司, 阪口義彦, 三澤尚明, 大畑雅典, 松崎茂展

    日本ブドウ球菌研究会プログラム・講演要旨集   58th   25   2013

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  • 難治性黄色ブドウ球菌感染症に対するバクテリオファージ療法の開発―治療用ファージバンクの構築―

    内山淳平, 竹村伊代, 氏原隆子, 松崎茂展, 大畑雅典

    感染症学雑誌   86 ( 5 )   637   2012.9

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  • ファージリガンド分子を利用した細菌検査法の開発

    内山淳平, 竹村伊代, 氏原隆子, 松崎茂展, 大畑雅典

    感染症学雑誌   86 ( 4 )   506   2012.7

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  • Genetic characterization of Pseudomonas aeruginosa bacteriophage KPP10 Reviewed

    Jumpei Uchiyama, Mohammad Rashel, Iyo Takemura, Shin-ichiro Kato, Takako Ujihara, Asako Muraoka, Shigenobu Matsuzaki, Masanori Daibata

    ARCHIVES OF VIROLOGY   157 ( 4 )   733 - 738   2012.4

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  • ファージリガンド分子を利用した細菌検査法の開発

    内山 淳平, 竹村 伊代, 氏原 隆子, 松崎 茂展, 大畑 雅典

    感染症学雑誌   86 ( 臨増 )   225 - 225   2012.3

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  • 難治性黄色ブドウ球菌感染症に対するバクテリオファージ療法の開発 治療用ファージバンクの構築

    内山 淳平, 竹村 伊代, 氏原 隆子, 松崎 茂展, 大畑 雅典

    感染症学雑誌   86 ( 臨増 )   291 - 291   2012.3

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  • Improved adsorption of an Enterococcus faecalis bacteriophage phiEF24C with a point mutation

    UCHIYAMA Jumpei, TAKEMURA Iyo, UJIHARA Takako, MATSUZAKI Shigenobu, DAIBATA Masanori

    日本細菌学雑誌   67 ( 1 )   122 - 122   2012.2

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  • 点突然変異を有するEnterococcus faecalisバクテリオファージphiEF24Cの吸収改善(Improved adsorption of an Enterococcus faecalis bacteriophage phiEF24C with a point mutation)

    内山 淳平, 竹村 伊代, 氏原 隆子, 松崎 茂展, 大畑 雅典

    日本細菌学雑誌   67 ( 1 )   122 - 122   2012.2

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  • 緑膿菌臨床分離株に対するバクテリオファージKPP12の溶菌効果の検討

    福田憲, 内山淳平, 森田珠恵, 石田わか, 角環, 松崎茂展, 大畑雅典, 福島敦樹

    日本角膜学会総会・日本角膜移植学会プログラム・抄録集   36th-28th   45   2012

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  • C型ボツリヌス毒素変換ファージのゲノム情報を基盤とした偽溶原性メカニズムの解析

    阪口義彦, OLIVA Maria A, MARTIN‐GALIANO Antonio J, ANDREU Jose M, 阪口政清, 内山淳平, 小椋義俊, 山本由弥子, 鈴木智典, 織田華絵, 津田千秋, 松崎茂展, 林哲也, 小熊惠二

    日本分子生物学会年会プログラム・要旨集(Web)   35th   WEB ONLY 3W3III-2   2012

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  • Analysis of deoxynucleosides in bacteriophages $ϕ$EF24C and K and the frequency of a specific restriction site in the genomes of members of the bacteriophage subfamily Spounavirinae Reviewed

    Uchiyama, Jumpei, Maeda, Yusuke, Takemura, Iyo, Gamoh, Keiji, Matsuzaki, Shigenobu, Daibata, Masanori

    Archives of virology   157 ( 8 )   1587 - 1592   2012

  • バクテリオファージ療法研究の現状と展望 Invited

    松崎茂展, 内山淳平, 竹村伊代, 大畑雅典

    週刊日本医事新報   4551 ( 4551 )   48 - 49   2011.7

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  • Urothelial/lamina propria spontaneous activity and the role of M3 muscarinic receptors in mediating rate responses to stretch and carbachol Reviewed

    Moro, Christian, Uchiyama, Jumpei, Chess-Williams, Russ

    Urology   78 ( 6 )   1442 - e9   2011

  • 黄色ブドウ球菌ファージS13′およびS24‐1ゲノム比較による尾部吸着タンパク質の同定と解析

    内山淳平, 竹村伊代, 佐藤美帆, 加藤伸一郎, 氏原隆子, 松崎茂展, 大畑雅典

    日本ブドウ球菌研究会プログラム・講演要旨集   56th   18   2011

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  • バクテリオファージによるマウス緑膿菌角膜炎の抑制効果

    福田憲, 石田わか, 角環, 森田珠恵, 内山淳平, 松崎茂展, 大畑雅典, 福島敦樹

    日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会プログラム・講演抄録集   48th-45th-54th   51   2011

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  • Isolation and characterization of a novel Staphylococcus aureus bacteriophage, phi MR25, and its therapeutic potential

    Hiroshi Hoshiba, Jumpei Uchiyama, Shin-ichiro Kato, Takako Ujihara, Asako Muraoka, Masanori Daibata, Hiroshi Wakiguchi, Shigenobu Matsuzaki

    ARCHIVES OF VIROLOGY   155 ( 4 )   545 - 552   2010.4

  • 腸球菌ファージφEF24C由来溶菌酵素ORF9の解析

    内山淳平, 林幾江, 竹村伊代, 氏原隆子, 竹内啓晃, 杉浦哲朗, 菅井基之, 大畑雅典, 松崎茂展

    日本細菌学雑誌   65 ( 1 )   180 - 180   2010.2

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  • 新規Serratia marcescensバクテリオファージKSP20,KSP90,およびKSP100の性状解析

    松下憲司, 内山淳平, 氏原隆子, 杉原重喜, 邑岡麻子, 大畑雅典, 松崎茂展

    日本細菌学雑誌   65 ( 1 )   179 - 179   2010.2

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  • マウスにおける治療用候補バクテリオファージの血中動態の比較検討

    内山淳平, 脇口宏, 松崎茂展

    感染症学雑誌   83 ( 5 )   616 - 616   2009.9

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  • Enterococcus faecalisファージφEF24C由来溶菌酵素ORF9の溶菌活性

    竹村伊代, 内山淳平, 竹内啓晃, 杉浦哲朗, 松崎茂展

    感染症学雑誌   83 ( 5 )   612 - 613   2009.9

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  • Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice

    UCHIYAMA Jumpei, MAEDA Yoshihiro, TAKEMURA Iyo, CHESS-WILLIAMS Russ, WAKIGUCHI Hiroshi, MATSUZAKI Shigenobu

    Microbiology and immunology   53 ( 5 )   301 - 304   2009.5

  • Enterococcus faecalisファージφEF24C由来溶菌酵素ORF9の溶菌活性

    竹村 伊代, 内山 淳平, 竹内 啓晃, 杉浦 哲朗, 松崎 茂展

    感染症学雑誌   83 ( 臨増 )   256 - 256   2009.3

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  • マウスにおける治療用候補バクテリオファージの血中動態の比較検討

    内山 淳平, 脇口 宏, 松崎 茂展

    感染症学雑誌   83 ( 臨増 )   260 - 260   2009.3

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  • 緑膿菌の新規溶原性バクテリオファージPAJU2の形態学的・遺伝学的解析

    内山淳平, 松崎茂展

    日本細菌学雑誌   64 ( 1 )   141 - 141   2009.2

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  • Tail-associated structural protein gp61 of Staphylococcus aureus phage phi MR11 has bifunctional lytic activity

    Mohammad Rashel, Jumpei Uchiyama, Iyo Takemura, Hiroshi Hoshiba, Takako Ujihara, Hiroyoshi Takatsuji, Koichi Honke, Shigenobu Matsuzaki

    FEMS MICROBIOLOGY LETTERS   284 ( 1 )   9 - 16   2008.7

  • In silico and in vivo evaluation of bacteriophage phi EF24C, a candidate for treatment of Enterococcus faecalis infections Reviewed

    Jumpei Uchiyama, Mohammad Rashel, Iyo Takemura, Hiroshi Wakiguchi, Shigenobu Matsuzaki

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY   74 ( 13 )   4149 - 4163   2008.7

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  • ファージ療法:現状と展望

    松崎茂展, 内山淳平, RASHEL Mohammad, 竹村伊代

    日本細菌学雑誌   63 ( 1 )   56 - 56   2008.2

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  • Revival of Bacteriophage ファージ療法 現状と展望

    松崎 茂展, 内山 淳平, Rashel Mohammad, 竹村 伊代

    日本細菌学雑誌   63 ( 1 )   56 - 56   2008.2

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  • MEDICAL TOPICS 第26回 バクテリオファージを用いる難治性感染症治療

    松崎茂展, 内山淳平, RASHEL Mohammad, 竹村伊代

    Lung Perspect   16 ( 1 )   98 - 103   2008.1

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  • MEDICAL TOPICS バクテリオファージを用いる難治性感染症治療

    松崎 茂展, 内山 淳平, Rashel Mohammad, 竹村 伊代

    THE LUNG-perspectives   16 ( 1 )   98 - 103   2008.1

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  • Isolation and characterization of a novel Enterococcus faecalis bacteriophage phi EF24C as a therapeutic candidate Reviewed

    Jumpei Uchiyama, Mohammad Rashel, Yoshihiro Maeda, Iyo Takemura, Shigeyoshi Sugihara, Kazue Akechi, Asako Muraoka, Hiroshi Wakiguchi, Shigenobu Matsuzaki

    FEMS MICROBIOLOGY LETTERS   278 ( 2 )   200 - 206   2008.1

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  • T-even-related bacteriophages as candidates for treatment of Escherichia coli urinary tract infections Reviewed

    Nishikawa, H, Yasuda, M, Uchiyama, J, Rashel, M, Maeda, Y, Takemura, I, Sugihara, S, Ujihara, T, Shimizu, Y, Shuin, T, others

    Archives of virology   153 ( 3 )   507 - 515   2008

  • A novel site-specific recombination system derived from bacteriophage $ϕ$MR11 Reviewed

    Rashel, Mohammad, Uchiyama, Jumpei, Ujihara, Takako, Takemura, Iyo, Hoshiba, Hiroshi, Matsuzaki, Shigenobu

    Biochemical and biophysical research communications   368 ( 2 )   192 - 198   2008

  • 腸球菌感染症に対する治療用バクテリオファージφEF24Cの性状とゲノム解析

    内山淳平, 松崎茂展, MOHAMMAD Rashel, 前田良浩, 竹村伊代, 邑岡麻子, 今井賞介

    感染症学雑誌   81 ( 5 )   607 - 607   2007.9

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  • ファージφMR11のtail関連成分GP61の機能的解析 φMR11由来staphylolytic物質の他の可能性(Functional analysis of the tail-associated component GP61 of phage φMRl11: another possible φMR11-derived staphylolytic agent)

    Mohammad Rashel, 松崎 茂展, 内山 淳平, 前田 良浩, 竹村 伊代, 今井 章介

    感染症学雑誌   81 ( 5 )   646 - 646   2007.9

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  • 薬剤耐性と対策 GPC 腸球菌感染症に対する治療用バクテリオファージφEF24Cの性状とゲノム解析

    内山 淳平, 松崎 茂展, Mohammad Rashel, 前田 良浩, 竹村 伊代, 邑岡 麻子, 今井 賞介

    感染症学雑誌   81 ( 5 )   607 - 607   2007.9

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  • Phage φMR11のtail関連成分GP61の機能的解析 φMR11由来staphylolytic物質の他の可能性(Functional analyis of the tail-associated component GP61 of phage φMR11: another possible φMR11-derived staphylolytic agent)

    Mohammad Rashel, 松崎 茂展, 内山 淳平, 前田 良浩, 竹村 伊代, 今井 章介

    感染症学雑誌   81 ( 臨増 )   229 - 229   2007.3

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  • 薬剤耐性と対策 GPC 腸球菌感染症に対する治療用バクテリオファージφEF24Cの性状とゲノム解析

    内山 淳平, 松崎 茂展, Mohammad Rashel, 前田 良浩, 竹村 伊代, 邑岡 麻子, 今井 章介

    感染症学雑誌   81 ( 臨増 )   165 - 165   2007.3

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  • 腸球菌感染症に対する治療用バクテリオファージφEF24Cのゲノム解析

    内山 淳平, 松崎 茂展, モハンマド ラシェル, 前田 良浩, 竹村 伊代, 黒田 正幸, 邑岡 麻子, 今井 章介

    日本細菌学雑誌   62 ( 1 )   144 - 144   2007.2

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  • In vivo and in vitro site-specific DNA recombination by phage φMR11-derived machinery

    モハンマド ラッシェル, 松崎 茂展, 黒田 正幸, 藤原 隆子, 内山 淳平, 前田 良浩, 竹村 伊代, 今井 章介

    日本細菌学雑誌   62 ( 1 )   141 - 141   2007.2

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  • ファージφMR11-由来機構によるIn vivoおよびin vitro部位特異的DNA組換え(In vivo and in vitro site-specific DNA recombination by phage φ MR11-derived machinery)

    ラッシェル・モハンマド, 松崎 茂展, 黒田 正幸, 藤原 隆子, 内山 淳平, 前田 良浩, 竹村 伊代, 今井 章介

    日本細菌学雑誌   62 ( 1 )   141 - 141   2007.2

  • バクテリオファージ療法

    内山淳平, 松崎茂展, 今井章介

    医学のあゆみ   219 ( 6 )   483 - 484   2006.11

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  • 細菌学・ウイルス学 バクテリオファージ療法

    内山 淳平, 松崎 茂展, 今井 章介

    医学のあゆみ   219 ( 6 )   483 - 484   2006.11

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  • 腸球菌感染症に対するファージ療法の検討

    明智和愛, 松崎茂展, 内山淳平, RASHEL M, 桜井慎吾, 氏原隆子, 邑岡麻子, 杉原重喜, 杉浦哲朗, 今井章介

    こうち   36 ( 1 )   12 - 12   2006.10

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  • バクテリオファージ療法:その現状と将来展望

    今井章介, 松崎茂展, RASHEL Mohammad, 内山淳平

    感染症学雑誌   80 ( 5 )   549 - 550   2006.9

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  • ワクチン,抗菌薬以外のアプローチ

    松崎茂展, RASHEL Mohammad, 内山淳平, 今井章介

    感染症学雑誌   80 ( 5 )   556 - 557   2006.9

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  • 小児科外来診療における耐性菌の現状と対策 ワクチン、抗菌薬以外のアプローチ

    松崎 茂展, Rashel Mohammad, 内山 淳平, 今井 章介

    感染症学雑誌   80 ( 5 )   556 - 557   2006.9

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  • 小児科外来診療における耐性菌の現状と対策 ワクチン,抗菌薬以外のアプローチ

    松崎 茂展, Rashel Mohammad, 内山 淳平, 今井 章介

    感染症学雑誌   80 ( 臨増 )   103 - 103   2006.3

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  • バクテリオファージ療法 その現状と将来展望

    今井 章介, 松崎 茂展, Rashel Mohammad, 内山 淳平

    感染症学雑誌   80 ( 臨増 )   92 - 92   2006.3

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  • 腸球菌感染症に対するファージ療法の検討:(2) 実験的腸球菌感染マウスに対するファージ投与効果

    明智和愛, 内山淳平, 松崎茂展, モハンマド ラッシェル, 干場浩, 桜井慎吾, 前田良浩, 氏原隆子, 邑岡麻子, 今井章介

    日本細菌学雑誌   61 ( 1 )   112 - 112   2006.2

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  • 腸球菌感染症に対するファージ療法の検討:(1) 新規腸球菌ファージの分離と性状解析

    内山淳平, 明智和愛, 松崎茂展, モハンマド ラッシェル, 黒田正幸, 小谷典弘, 上原良雄, 杉原重喜, 杉浦哲朗, 今井章介

    日本細菌学雑誌   61 ( 1 )   111 - 111   2006.2

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  • Bacteriophage therapy : a revitalized therapy against bacterial infectious diseases

    MATSUZAKI Shigenobu, RASHEL Mohammad, UCHIYAMA Jumpei, SAKURAI Shingo, UJIHARA Takako, KURODA Masayuki, IKEUCHI Masahiko, TANI Toshikazu, FUJIEDA Mikiya, WAKIGUCHI Hiroshi, IMAI SHOSUKE

    Journal of Infection and Chemotherapy   11 ( 5 )   211 - 219   2005.10

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  • ヒト細胞で機能する黄色ブドウ球菌ファージφMR11由来部位特異的組換えシステム

    氏原隆子, 松崎茂展, 黒田正幸, RASHEL M, 明智和愛, 内山淳平, 桜井慎吾, 邑岡麻子, 今井章介

    日本細菌学雑誌   60 ( 1 )   63 - 63   2005.2

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  • Geranyl-geranyl-acetoneによるHSP70の発現効果と抗apoptosis効果について

    岸弓景, 赤尾淳平, 磯山直仁, 松村正文, 内山浩一, 土田昌弘, 高井公雄, 内藤克輔

    日本泌尿器科学会雑誌   95 ( 2 )   2004

  • Geranyl-geranyl-acetone (GGA,セルベックス)の抗apoptosis効果について

    岸弓景, 赤尾淳平, 磯山直仁, 松村正文, 内山浩一, 土田昌弘, 高井公雄, 内藤克輔

    移植   38   2003

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Industrial property rights

  • 牛伝染性リンパ腫ウイルス株の伝播性および発症の危険度を評価する方法

    村上 裕信, 曽川 一幸, 内山 淳平, 佐藤 礼一郎

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    Applicant:学校法人麻布獣医学園

    Application no:特願2024-039809  Date applied:2024.3.14

    Announcement no:特開2024-134535  Date announced:2024.10.3

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  • 乳酸菌含有組成物

    福山 朋季, 内山 淳平, 竹田 志朗

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    Applicant:学校法人麻布獣医学園

    Application no:特願2022-139646  Date applied:2022.9.2

    Announcement no:特開2023-037613  Date announced:2023.3.15

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  • 酸素ナノバブルを含む医薬

    永根 大幹, 内山 淳平, 山下 匡, 杉本 義孝

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    Applicant:学校法人麻布獣医学園

    Application no:特願2021-157759  Date applied:2021.9.28

    Announcement no:特開2022-056407  Date announced:2022.4.8

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  • アレルゲン不活化剤の評価方法及びアレルゲン不活化剤の評価キット

    阪口 雅弘, 内山 淳平, 吉田 愛美, 水上 圭二郎, 蔵田 圭吾

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    Applicant:学校法人麻布獣医学園

    Application no:JP2021016529  Date applied:2021.4.23

    Patent/Registration no:特許第7126665号  Date registered:2022.8.19 

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  • 乳酸菌含有組成物

    阪口 雅弘, 内山 淳平, 福山 朋季

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    Applicant:学校法人麻布獣医学園

    Application no:特願2020-038610  Date applied:2020.3.6

    Announcement no:特開2021-136951  Date announced:2021.9.16

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  • 乳酸菌含有組成物

    阪口 雅弘, 内山 淳平, 福山 朋季

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    Applicant:学校法人麻布獣医学園

    Application no:特願2020-038610  Date applied:2020.3.6

    Announcement no:特開2021-136951  Date announced:2021.9.16

    Patent/Registration no:特許第7515153号  Date registered:2024.7.4 

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  • バクテリオファージ由来エンドライシン

    内山 淳平, 金木 真央

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    Applicant:日本全薬工業株式会社

    Application no:特願2020-006483  Date applied:2020.1.20

    Announcement no:特開2021-112152  Date announced:2021.8.5

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  • バクテリオファージ由来エンドライシン

    内山 淳平, 金木 真央

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    Applicant:日本全薬工業株式会社

    Application no:特願2020-006483  Date applied:2020.1.20

    Announcement no:特開2021-112152  Date announced:2021.8.5

    Patent/Registration no:特許第7454211号  Date registered:2024.3.13 

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  • 新規バクテリオファージおよび細菌性眼内炎治療剤

    福田 憲, 松崎 茂展, 福島 敦樹, 大畑 雅典, 内山 淳平

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    Applicant:国立大学法人高知大学

    Application no:JP2019009112  Date applied:2019.3.7

    Publication no:WO2019-176729  Date published:2019919

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  • 新規バクテリオファージおよび細菌性眼内炎治療剤

    福田 憲, 松崎 茂展, 福島 敦樹, 大畑 雅典, 内山 淳平

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    Applicant:国立大学法人高知大学

    Application no:JP2019009112  Date applied:2019.3.7

    Patent/Registration no:特許第7289538号  Date registered:2023.6.2 

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  • 細菌選択培地

    内山 淳平, 村上 裕信

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    Applicant:学校法人麻布獣医学園

    Application no:特願2018-114145  Date applied:2018.6.15

    Announcement no:特開2019-216609  Date announced:2019.12.26

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  • B群連鎖球菌選択的増菌用培地

    内山 淳平, 阪口 雅弘, 花木 秀明, 松井 秀仁

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    Applicant:学校法人麻布獣医学園, 学校法人北里研究所

    Application no:特願2016-247315  Date applied:2016.12.21

    Announcement no:特開2018-099080  Date announced:2018.6.28

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  • 黄色ブドウ球菌を検出する方法、黄色ブドウ球菌測定用メンブレン、及び黄色ブドウ球菌測定用キット

    内山 淳平, 内山 伊代, 花木 秀明, 松井 秀仁, 大畑 雅典, 松崎 茂展

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    Applicant:学校法人麻布獣医学園, 学校法人北里研究所

    Application no:特願2014-046922  Date applied:2014.3.10

    Announcement no:特開2015-169632  Date announced:2015.9.28

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  • 黄色ブドウ球細菌に結合するタンパク質及びそのタンパク質を利用した黄色ブドウ球細菌の測定方法。

    大畑 雅典, 松崎 茂展, 内山 淳平, 竹村 伊代

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    Applicant:学校法人麻布獣医学園

    Application no:特願2012-160613  Date applied:2012.7.19

    Announcement no:特開2013-066456  Date announced:2013.4.18

    Patent/Registration no:特許第5925075号  Date registered:2016.4.28  Date issued:2016.4.28

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  • 黄色ブドウ球細菌に結合するタンパク質及びそのタンパク質を利用した黄色ブドウ球細菌の測定方法。

    大畑 雅典, 松崎 茂展, 内山 淳平, 竹村 伊代

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    Applicant:国立大学法人高知大学

    Application no:特願2012-160613  Date applied:2012.7.19

    Announcement no:特開2013-066456  Date announced:2013.4.18

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Awards

  • AgriFood SBIR ピッチ・マッチング2025 グッドブレークスルーテックプレゼン賞

    2025.3   生物系特定産業技術研究支援センター(BRAIN)、Beyond Next Ventures株式会社、株式会社クニエ  

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  • 岡山イノベーションコンテスト2024 サンマルク賞(企業賞)

    2024.11   岡山イノベーションプロジェクト  

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  • 2023年度日本ヘリコバクター学会学術集会賞(優秀賞)

    2024.6   日本ヘリコバクター学会  

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  • 岡大ピッチコンテスト2023〜ハーベスト・ピッチ〜 最優秀賞、三井住友信託銀行賞、NEDO賞

    2023.9   岡山大学  

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  • 創立四半世紀記念研究成果発表奨励賞

    2022.3   日本臨床微生物学会  

    内山淳平

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  • 第68回日本細菌学会中国・四国支部総会 若手研究者奨励賞受賞

    2015.9   日本細菌学会中国・四国支部総会  

    内山淳平

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  • 高知大学研究顕彰制度「若手教員研究優秀賞」

    2014.3   高知大学  

    内山淳平

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  • 高知信用金庫・安心友の会 学術賞

    2014.2   高知信用金庫  

    内山淳平

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  • 大学院生奨励賞

    2009.3   高知大学  

    内山淳平

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  • エンデバー賞

    2008.1   オーストラリア政府  

    内山淳平

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  • Dean’s Commendation, Faculty of Science

    2004.12   University of the Sunshine Coast, Australia  

    内山淳平

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Research Projects

  • 改変型人工抗菌酵素による薬剤耐性グラム陰性桿菌感染症の治療基盤の確立

    Grant number:25K02692  2025.04 - 2028.03

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    内山 淳平

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    Grant amount:\18200000 ( Direct expense: \14000000 、 Indirect expense:\4200000 )

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  • Developmment of novel bacterial detection methods using bacteriophages that infect bacteria with high specificity

    Grant number:24K08465  2024.04 - 2027.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    渡辺 茂, 内山 淳平

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

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  • 多剤耐性緑膿菌感染症に対する超殺菌作用を有する人工抗菌酵素の創出

    Grant number:24K11653  2024.04 - 2027.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    内山 伊代, 内山 淳平

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

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  • 黄色ブドウ球菌眼内炎におけるDAMPsによる炎症制御機構の解明および治療法の開発

    Grant number:24K12764  2024.04 - 2027.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    福田 憲, 内山 淳平, 石田 わか, 岸本 達真, 山城 健児

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

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  • ファージ吸着分子結合マイクロ粒子を利用した抗C. difficile治療法の創出

    Grant number:22K08580  2022.04 - 2025.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    内山 淳平

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

    ディフィシル菌(Clostridioides difficile)は、感染症の治療には抗菌薬が使用される。多くの抗菌薬に耐性であること、抗菌薬の副作用の点から、本感染症に対して抗菌薬に依存しない治療法の開発が求められている。
    細菌ウイルスであるバクテリオファージ(ファージ)は細菌種特異的に感染するという特徴を有する。ファージの菌種特異的感染には、宿主菌への吸着が第一義的に重要で、ファージの尾部に存在する尾繊維やスパイクなどの吸着に関与する分子(ファージ吸着分子)と細菌表層の特異的な相互作用に起因する。ファージ吸着分子には、それ単独で菌種特異的な吸着能力を有する。
    研究代表者は、世界に先駆けて、ファージ吸着分子は、抗体と同等の高い性能を有しているばかりでなく、開発コストや製造に関して優れており、細菌特異的な抗体の代替えとして利用できることを提唱した。研究代表者は、C. difficile腸炎の治療法の問題に対して、ファージ吸着分子を結合したマイクロ粒子を投与することで、腸管内でマイクロ粒子がC. difficileが特異的に凝集体を形成し、糞便として排出されることでC. difficileを除菌する方法を考案した。本治療法は、難渋化するC. difficile腸炎の問題を解決する新しい治療薬のシーズとなると考えた。
    本研究課題では、4つの研究項目を実施する:(I)「C. difficileファージ吸着分子の作製」、(II)「C. difficile特異的ファージ吸着分子の結合メカニズムの解明」、(III)「ファージ吸着分子結合マイクロ粒子の作製」、(IV)「C. difficile腸炎マウスモデルに対するファージ吸着分子結合マイクロ粒子投与による評価」。本年度は、研究項目(I)を実施した。

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  • KHP30様ファージのピロリ菌認識機構の解明とピロリ菌の迅速検査・除菌への応用

    Grant number:22K08593  2022.04 - 2025.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    松崎 茂展, 内山 淳平, 岩本 昌大

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

    本研究の最終目標は、ピロリ菌に感染するバクテリオファージ(ファージ)KHP40のリガンド分子および宿主におけるレセプター分子を特定し、それらを検査や除菌に応用することである。
    まず宿主菌におけるKHP40ファージのためのレセプター分子を特定するための第一段階として、当該ファージに対する吸着能が大きく異なる宿主の探索を試みた。まず標準宿主である3401株に対する吸着活性を検討した、その結果30分ほどで約50%が吸着しその後は徐々に吸着が進行する状況が示された。次に、3401株、26695株、HPK5株において、実験開始後60分における吸着活性を比較した。その結果、3401に対する吸着能が最も高く、次いで26695株が高かった。一方、HPK5株に対しては、吸着は認められるものの、その活性は3401株、26695株に比べかなり低かった。この結果は、KHP40の吸着活性が、宿主菌株によって大きく異なることを示している。
    以上の吸着実験の結果は、ファージの増殖宿主をピロリ菌3株(3401、26695、HPK5)とした場合のすべてでほぼ同じであった。すなわち、増殖宿主は、KHP40の吸着能にほとんど影響を与えないことが示された。
    上記結果から、3401株(26695株)とKHP5株の吸着活性の違いは、レセプター分子が相互に異なっているためであると予想される。この相違は、以降のレセプター分子特定および分離の指標となると期待され、次のステップに進むための重要な知見がえられたと考えられる。

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  • Development of a novel detection method for whole bacterial cells using bacteriophages as recognition elements

    Grant number:21K05113  2021.04 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    渡辺 茂, 内山 淳平, 仁子 陽輔

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

    感染症を取り巻く環境は,細菌性食中毒の集団感染,院内感染の多発や新興・再興感染症の発生など多様化しており,早期診断・治療および二次感染の予防には迅速な微生物検査が不可欠である.宿主細菌に対して特異的に感染するバクテリオファージ(“天敵ウイルス”)を機能性ナノ粒子とハイブリッド化することでPCR法や免疫検出法に代わる新たな細菌検出技術への応用が期待できる.高感度かつ高選択的な細菌検出法の開発には,検体中,検出したい細菌にのみ結合し,その情報を我々が検出可能な物理信号に変換する蛍光プローブの開発が不可欠である.本年度は,ファージと蛍光性ナノエマルションを利用した細菌の蛍光検出法の開発について検討した.
    蛍光法を利用した高感度・高信頼性の細菌検出には,光安定性に優れ強力な蛍光を発する信号発信部位を有する蛍光プローブが求められる.これまでにファージの頭部に蛍光色素を結合させた蛍光プローブが開発されているが,輝度が低い上に光安定性にも欠ける.そこでオイルと界面活性剤からなる粒径が数十nmのナノエマルションに大量の蛍光色素を溶解させることで,光安定性に優れ高輝度な蛍光性ナノエマルションを開発した.
    次に表面にカルボキシル基を導入した蛍光性ナノエマルションを合成し,活性エステルへと導いた後,ファージとアミド結合を介して結合させることで蛍光性ナノエマルション修飾ファージを合成した.これを各種細菌と混合後,蛍光顕微鏡を用いて観察した.試料中の細菌がファージの宿主細菌(S.aureus)である場合,細菌から強力な蛍光が観察されたのに対して,宿主以外の細菌(E.coliなど)からは蛍光が観察されることがなく,蛍光性ナノエマルション修飾ファージを利用して,選択的に細菌を蛍光検出できることがわかった.

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  • Screening of drug discovery seed compounds for recurrent C. difficile infection

    Grant number:21K08514  2021.04 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Matsui Hidehito

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

    Recurrence of C. difficile infection is a serious problem in clinical settings. In this study, we aimed to identify the seed compound of drug development for CDI. ELISA system for Toxin B and binary toxin were established, and a library of natural compounds was evaluated using the screening method for inhibitory activity to bacterial growth, spore formation, or toxin production. From the screening results, the compounds with inhibitory activity for bacterial growth, spore formation, and toxin production were shown in 19, 10, and 7 compounds, respectively. These hit compounds indicated the antibacterial activity superior to existing antimicrobial agents or specific inhibitory activity for toxin production or spore formation, therefore these compounds are expected for further evaluation in the future.

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  • Development of the new multidrug-resistant tuberculosis control method to use bacteriophage lysin

    Grant number:19K08953  2019.04 - 2022.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Matsuzaki Shigenobu

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    Tuberculosis is not a disease of the past, but is an infectious disease that still causes the largest number of deaths annually among infectious diseases worldwide. Anti-tuberculosis drugs are used for treatment, but multidrug-resistant Mycobacterium tuberculosis that are ineffective against them have emerged and have become a major therapeutic problem. In order to solve this problem, it is important to introduce a method for controlling M. tuberculosis that is independent of antibacterial agents.
    In this study, we investigated the possibility of controlling M. tuberculosis using the lytic enzyme (lysin) group possessed by bacterophage Y2, which can infect both M. tuberculosis and M. smegmatis. The lysin-mixed solution showed growth inhibitory and/or lytic activity against M. smegmatis. This strongly suggests that phage-lysin therapy can be applied in the control of tuberculosis.

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  • Study for a molecular machinery of the host recognition by Clostridioides difficile phage to develop the advanced therapy

    Grant number:19K07560  2019.04 - 2022.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Sakaguchi Yoshihiko

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    Clostridioides difficile infection (CDI), which is caused by excessive proliferation of C. difficile, is one of the antibacterial drug-related diarrhea and enteritis. Therefore, it is important to develop a new and specific treatment method for C. difficile disinfection. The current study was focused on bacteriophage (phage) as a potential treatment. Phage binds specifically to the host bacterium and generates a bactericidal activity. In this study, the recombinant phage proteins were expressed and purified and the bindings between these proteins and C. difficile were examined using enzyme-linked immunosorbent assay (ELISA) and western blot analysis. The results of the study showed a dose- and a time-dependent binding.

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  • 細菌培養検査の精度を改善する選択的抗菌剤の基盤技術の開発

    2019 - 2020

    科学技術振興機構  産学が連携した研究開発成果の展開 研究成果展開事業 研究成果最適展開支援プログラム(A-STEP) 機能検証フェーズ 試験研究タイプ 

    内山 淳平

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    Authorship:Principal investigator 

    細菌培養検査において、雑菌が培地に増殖し、目的とする細菌の検出が困難となる事例が報告されている。本研究では、雑菌を選択的に殺菌可能な抗菌剤をウイルスから分離し、本問題を解決可能な試薬の研究開発を行う。

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  • Development of novel bacterial detection methods using bacteriophages as recognition elements

    Grant number:18K05174  2018.04 - 2022.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Watnabe Shigeru

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    Phage-modified konpeito-like gold nanoparticles have been prepared by self-assembling phage on the surface of gold nanoparticles accumulated on glass beads. The konpeito-like gold nanoparticles were mixed with various bacteria and observed using a dark-field microscope. The bacteria were easily detected by the strong scattered light emitted by the konpeito-like gold nanoparticles bound to the bacteria (detection limit (LOD) 10000 cfu/ml). The gold nanoparticles do not bind to any host other than the host of the phage loaded on the surface of the particles, and the selectivity of the gold nanoparticles reaches not only the genus but also the species level. This method has the potential to control the bacterial selectivity of gold nanoparticles by changing the phage used, and is expected to be applied to the rapid and highly selective detection of bacteria.

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  • Examination of the persistent infection mechanism of Helicobacter pylori by phage lysogenization

    Grant number:18K07127  2018.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Uchiyama Jumpei

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

    Helicobacter pylori is a pathogenic bacterium involved in diseases, for example, chronic gastritis, gastric ulcer, and gastric cancer. Since phages often have useful genes for host bacteria, phage lysogenization to bacteria can confer the bacteria the traits such as survival strategy in the environment and pathogenicity. In recent years, lysogenic phage infecting H. pylori has been discovered. Since many defective phages have been often found In the H. pylori genomes, the traits are expected to be conferred to H. pylori by phage infections. However, the traits of H. pylori by phage lysogenization are hardly understood. In this study, lysogenization of H. pylori phages was clarified to improve the bacterial mobility.

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  • Structure analysis of Staphylococcus bacteriophage S13'

    Grant number:18K06154  2018.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Miyazaki Naoyuki

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    We analyzed the infection mechanisms of Staphylococcus bacteriophages S13’ and S6 by cryo-electron microscopy for practical and effective application of phage therapy for the Staphylococcus aureus infectious diseases. The S13’ is a small phage in the Podoviridae family with a head diameter of about 50 nm and a non-contractile tail length of about 40 nm, while the S6 is a large Myoviridae phage with a diameter of about 140 nm and a contractile tail length of about 250 nm. We succeeded to build atomic models for almost all of the proteins that make up the phage particle. On the other hand, we determined the tail structures of S6 before and after contraction, and then we reveals the contractile mechanism of the tail.

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  • Pathogenicity analysis of bovine leukemia virus

    Grant number:17K15385  2017.04 - 2019.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Murakami Hironobu, Sato Reiichiro, Uchiyama Jumpei, Maeda Yosuke, Kato Hajime

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    To research whether a genetic variation affects viral properties, phylogenetic analysis was performed using whole BLV genome and revealed to be classified three group in BLV wild-type strains. In addition, the groups were associated with virus productivity. The one of three group strains classified in this study showed high virus productivity and had an advantage for transmissibility in field. Moreover, pathogenesis was different among wild-type strains, but some strains harbored deletion mutation and showing low viral production had high pathogenesis. Taken together, transmissibility and pathogenesis would be independently decided by different genetic factors.

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  • Study of the molecular machinery of host recognition by the Clostridium botulinum type C and D neurotoxin-converting phages

    Grant number:16K08785  2016.04 - 2019.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Sakaguchi Yoshihiko

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    Grant amount:\4810000 ( Direct expense: \3700000 、 Indirect expense:\1110000 )

    Our ongoing study revealed that botulinum neurotoxin genes are present in the bacteriophage (phage) genomes and that, consequently, phages participate in neurotoxin-gene transfer to Clostridium botulinum types C and D. If so, a strategy mediated by phages to inhibit neurotoxin-gene transfer to the hosts would be of great help to block botulism outbreaks. In this study, we aimed to identify the infectious mechanism of C. botulinum type C and D phages. We performed genomics analyses of type C and D phages, which was useful to specify the phage adsorption rate that is required for adherence to the host surface. We found that phages carry several interesting genes adapted to our purpose, which are likely to encode the proteins that compose the phage tail. These novel findings will be very useful to identitify the machinery of the phage host interaction in the process of infection-mediated neurotoxin-gene transfer.

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  • Analysis of MRSA evolution mechanism by generalized transduction

    Grant number:15K19095  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    UCHIYAMA JUMPEI, MATSUZAKI Shigenobu, KUROKAWA Kenji, MIYAZAKI Naoyuki, MURATA Kazuyoshi, UCHIYAMA Iyo

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    Grant amount:\4030000 ( Direct expense: \3100000 、 Indirect expense:\930000 )

    In this study, we analyzed the horizontal gene transfer in the environment, using the model of phage transduction of phage S6 in MRSA. First, analyzing phylogeny of phage based on the whole genome, phage S6 was related to the other phage infecting Gram-positive bacteria and that infecting Gram-negative bacteria, which suggested that there may be specific phage group with transducing ability. Second, phage S6 has ability to adsorb the Staphylococcus aureus cells via beta-glycosilation of wall teichoic acids on the cell wall. Third, phage S6 was considered to package the host DNA, transfer it to the new recipient cells, and the gene acquisition occurred by homologous recombination.

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  • Basic research to establish Bacteriophage treatment for chronic otitis media as a novel treatment strategies using the activity of bacteriolysis

    Grant number:15K10756  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Komori Masahiro

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    Grant amount:\4810000 ( Direct expense: \3700000 、 Indirect expense:\1110000 )

    Bacteriophage is a virus which infects to bacterium and breaks them. Since having specificity to host bacterium, bacteriophage never infects to the indigenous bacterium and human cells. Thus, when host bacterium disappears, the bacteriophage becomes extinct. In addition, it does not have tolerance to antibiotics and also breaks the biofilms of bacterium.
    This study aimed to confirm the efficacy and safety on the treatments for chronic otitis media. Staphylococcus aureus and/or bacteriophage were injected into the middle ear cavity. Although their concentration to work was much higher than expected, the inflammation disappeared by the bacteriophage treatment. No mice with bad condition, death and doubted inner ear damages were found. The study indicated the bacteriophage is effective for the treatments to the otitis media, however, further studies will be required for the toxicity.

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  • Development of novel treatment by using bacteriophage for ocular diseases induced by bacterial infection

    Grant number:26462692  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    FUKUDA Ken

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    Grant amount:\4940000 ( Direct expense: \3800000 、 Indirect expense:\1140000 )

    We examined the therapeutic effects of bacteriophage eye drop on methicillin-resistant Staphylococcus aureus keratitis in rabbit. The clinical corneal score was significantly lower in rabbits treated by bacteriophage eye drop than in those treated by anti-biotic eye drop or control. The bacterial load in cornea among the vehicle-treated rabbit, anti-biotic-treated rabbit, and bacteriophage-treated rabbit were not significantly changed.
    We then examined the bacterial endophthalmitis in rabbit and mouse. The injection Pseudomonas aeruginosa or Enterococcus faecalis into vitreous cavity in mice stably induced severe endophthalmitis including massive infiltration of neutrophils and destruction of tissue. Injection of phage into vitreous cavity in mice with endophthalmitis significantly suppressed clinical score and viable bacteria in the eyeball.

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  • Elucidation of a relationship of bacteriophage to pathogenicity of Helicobacter pylori and development of eradication system to H. pylori using bacteriophage.

    Grant number:26461504  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    MATSUZAKI Shigenobu

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    Grant amount:\4940000 ( Direct expense: \3800000 、 Indirect expense:\1140000 )

    In this study, we aimed at collection of information about a bacteriophage-exclusion system (restriction-modification system) in Helicobacter pylori, to develop an effective sterilization method of drug-resistant H. pylori from the stomach using bacteriophages KHP30 and KHP40. The results indicated that H. pylori had multiple functional restriction-modification systems, suggesting strongly that the bacteriophages must be adapted to all H. pylori-possessed restriction-modification systems for effective sterilization.

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  • Analysis of tail adsorbed protein of Clostridium botulinum types C and D neurotoxin-converting phage and its host bacterial receptors

    Grant number:25460541  2013.04 - 2016.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Sakaguchi Yoshihiko, MATSUZAKI Shigenobu, UCHIYAMA Jumpei

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    Grant amount:\5200000 ( Direct expense: \4000000 、 Indirect expense:\1200000 )

    Because Clostridium botulinum types C and D produce botulinum neurotoxin, causing serious symptom botulism, they are recognized as severe pathogen you should prevent spreading in food and animal industries. The botulinum neurotoxin genes are coded on the prophage genomes, and so inhibition of lateral gene transfer mediated by bacteriophage (phage) can be one of the preventions for the disease. Thus, we investigated the adsorption mechanism of C. botulinum type C neurotoxin-converting phage, phage c-st on the genetic point. Based on the comparative genomics and identification of phage virion genes, we got at a speculation that several genes associated with phage adsorption. We are in advanced studies of the findings.

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  • ポイント・オブ・ケア診断を目指したバクテリオファージ尾部吸着分子を利用した簡易迅速細菌検出技術の開発

    2013.04 - 2014.03

    黒住医学研究振興財団  第21回研究助成金  第21回研究助成金

    内山淳平

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    Authorship:Principal investigator 

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  • ポイント・オブ・ケア診断キットを目指したファージ尾部吸着タンパク質を利用するイムノクロマトグラフフィー法の技術開発

    2013

    産学が連携した研究開発成果の展開 研究成果展開事業 研究成果最適展開支援プログラム(A-STEP) 探索タイプ 

    内山 淳平

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    近年、細菌検査におけるポイント・オブ・ケア診断キットの社会的ニーズが高まっている。本申請研究課題では、「ポイント・オブ・ケア診断キットを目指したファージ尾部吸着タンパク質を利用するイムノクロマトグラフィー法の技術開発」を行った。本研究で提案する技術は、ファージ尾部吸着タンパク質を細菌検出に使用する技術である。イムノクロマトグラフィー法の変法であるため、ファージクロマトグラフィー法と命名した。はじめに、黄色ブドウ球菌を標的とし研究開発を行った。ファージクロマトグラフィー法は、現在、流通しているキット類と比較して、感度・精度は優れており、また、他の細菌種との交差反応は認められていない。既存技術と比較して技術的優位性を有しており、十分技術移転可能であると考えられる。現在、本法の更なる技術改良を行っている。さらに、様々な細菌種に対するファージ吸着タンパク質の分離を行い、ファージクロマトグラフィー法の構築を目指して研究を継続している。 本研究成果により、ファージ尾部吸着分子の十分技術移転が可能であるという結果を得た。今後、研究を継続して行い、様々な菌種に対して、高感度に検出可能なファージクロマトグラフィー法を作製し、事業化を目指したい。

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  • Examination of anti-viral activity of novel phage-derived nucleosides

    Grant number:24791025  2012.04 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    UCHIYAMA Jumpei, GAMOH Keiji

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    Nucleic acid analogs, which the structure of the nucleoside is based, is used in chemotherapy against viral infections. Some of the bacteriophages (phages) have unique genomic DNAs. In this study, we searched novel nucleic acids from phage genomic DNA, which can become drug discovery platform for anti-viral drugs.
    The phage genomic DNAs were analyzed using LC-MS. As a result, most of the phages were revealed to have normal genomic DNAs. On the other hand, Staphylococcus aureus phage S6 DNA was revealed to contain uracil in place of thymine as a nucleic acid base. Unfortunately, it did not lead to the discovery of novel nucleic acids that can be drug discovery platform for anti-viral drugs in the present study.

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  • Development of the new Helicobacter pylori eradication method for using a phage lytic enzyme

    Grant number:23591478  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    MATSUZAKI Shigenobu, TAKEUCHI Hiroaki, UCHIYAMA Jumpei, DAIBATA Masanori

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\5330000 ( Direct expense: \4100000 、 Indirect expense:\1230000 )

    To develop a novel eradication method of Helicobater pylori using bacteriolytic activity of a bacteriophage (phage) KHP30, the morphological, physical, and genetic aspects and the life-cycle of KHP30 have been studied. The host-range of KHP30 was about 65%, suggesting that it is suitable for application use as antibacterial agent. The complete DNA nucleotide sequence was determined and the open reading frames (ORFs) were annotated. The genome consisted of 26 kbp including 30 ORFs. By homology search of the genome, the ORF for the holin protein, one component of general lytic system, was found, but the ORF for the lysin, the counterpart of the system was not found. Therefore, H. pylori phage KHP30 was supposed to have a unique bacteriolytic system different from those of other phages.

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  • Development of a new rapid bacterial identification using bacteriophage tail ligand molecule

    Grant number:22890129  2010 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up  Grant-in-Aid for Research Activity Start-up

    UCHIYAMA Jumpei, DAIBATA Masanori, MATSUZAKI Shigenobu, UCHIYAMA Iyo

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3016000 ( Direct expense: \2320000 、 Indirect expense:\696000 )

    Infection control is extremely important to prevent infection spread. Rapid bacterial examination in infection control enables early treatment of patients, reduction of medical costs and prevention of infection spread. Thus, the development of more rapid bacterial detection systems is urgently required. The principal Investigator focused on the specific bacteriophage(phage ; bacterial virus) structural proteins contributed to the bacteria-species-specific binding ability, and examined the applicability of the phage molecule to bacterial detection system. As a result, the phage tail molecule was revealed to be potentially used for the rapid bacteria detection system.

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