Research Projects -
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Possible Mechanisms of Progression of Periodontits by MMP-3 in Diabetic Patients
Grant number：20592428 2008 - 2010
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
NARUISHI Koji, HATANAKA Kazu, TAKASHIBA Syougo, MINESHIBA Junji, OMORI Kazuhiro
Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）
Diabetic patients are susceptible to severe inflammatory periodontitis. In the present study, we found that high glucose increased MMP-3, but not sIL-6R production in gingival fibroblasts. In addition, sIL-6R production was suppressed by MMP-3 inhibitor in THP-1 macrophages. These results suggest that MMP-3 has a key role in developing severe periodontitis in diabetic patients. Furthermore, it has been considered that IL-6 signals are very important factor surrounding gingival fibroblasts/macrophage interaction in severe periodontitis seen in diabetic patients.