記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objectives: Cathepsin K is expressed by osteoclasts and synovial fibroblasts and degrades key components of bone and cartilage. Inhibition of cathepsin K protease activity may be beneficial for the prevention of bone erosion and cartilage degradation in rheumatoid arthritis (RA). The collagen-induced arthritis (CIA) rat model is well established for studying the pathology and treatment of RA. We investigated the effect of ONO-KK1-300-01, a cathepsin K inhibitor (CKI), on arthritis and bone mineral density (BMD) in rats with CIA. Methods: Seven-month-old female Sprague Dawley rats were divided into 5 groups: rats without CIA (CNT); CIA rats that underwent ovariectomy (OVX) and were treated with CKI; CIA rats that underwent OVX and were treated with vehicle (Veh); CIA rats that underwent sham surgery and were treated with CKI; and CIA rats that underwent sham surgery and were treated with Veh. CKI was orally administered at a dose of 15 mg/kg, thus initiating collagen sensitization, until death at 4 weeks. We evaluated hind paw thickness and the arthritis score every week until death. Radiographs of the resected left foot were obtained with a soft X-ray apparatus. Destruction of bone and cartilage was classified and scored as previously described by Engelhardt et al. BMD was measured by bone densitometry at the halfway point between the distal metaphysis and the diaphysis of the resected right femur. We also performed histomorphometry of the proximal left tibia, histological evaluation of arthritis, and a bone strength test. Results: CKI administration significantly reduced hind paw thickness and the arthritis score, and prevented a decrease in BMD. The radiographic score was significantly lower in the CKI group than in the Veh group. In the histomorphometric analysis, bone-resorption parameters were significantly lower in the CKI groups than in the Veh groups. CKI significantly inhibited synovial proliferation in the CIA rats. In the bone strength test, the ultimate stress was significantly higher in the CKI groups than in the Veh groups. Conclusion: Our findings indicate that cathepsin K inhibitors may inhibit systemic and local bone loss, ameliorate arthritis, and attenuate the decrease of bone strength in an animal model of arthritis.

DOI： 10.1016/j.bonr.2018.05.006

PubMed

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：医用画像情報学会  

<p>The measurement method for the noise property of the digital tomosynthesis image has not been standardized in any guidelines or papers. Currently, a noise in a digital tomosynthesis image has been commonly measured using a 2-D fast Fourier transform（2D-FFT）method. The purpose of this paper is to propose a new method for measuring the noise property of a digital tomosynthesis image, which applies the radial frequency（Radial）method with a limited angular range （LAR）for data acquisition. Although the Radial method was used to obtain the power spectrum from all angles（360°）around the origin, the LAR method acquired the power spectrum in the limited angle regions. When the noise properties acquired by the LAR method with the limited angles of 3°, 5° and 15° were compared to those obtained through the Radial method and the 2D-FFT method. The results of the LAR method had the large differences compared to those of the Radial method in the u-axis direction. Further, the noise property of the LAR method and the 2D-FFT method showed a higher correlation in both axis directions. In conclusion, we believe that the noise properties of the digital tomosynthesis image can be measured by using the LAR method with a limited angle of 5°.</p>

DOI： 10.11318/mii.35.6

CiNii Article

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Our aim in this study was to evaluate the effect of geometry for measuring section thickness in tomosynthesis by using a metal bead device (bead method). Tomosynthesis images were obtained from two types of tomosynthesis equipment, Safire17 (ST, Shimadzu, Kyoto, Japan) and XR650 (GT, GE Healthcare, Milwaukee, WI). After tomosynthesis radiography with each device, the bead tomosynthesis images were obtained by image reconstruction. The digital profile was obtained from the digital value of the bead central coordinate in the perpendicular direction, and we acquired the slice sensitivity profile (SSP). The section thickness was defined with the full width at half maximum obtained from the SSP. We investigated the change in section thickness under different evaluation conditions: the angular range, the height of the bead position, the source-image receptor distance (SID), and image processing. The section thickness decreased when the angular range and height of the bead position increased. Also, the section thickness varied with a change in the SID. The section thickness differed according to the geometry for measuring the section thickness. Thus, the effect of the geometry used for measurement should be considered when the section thickness in tomosynthesis is measured by the bead method.

DOI： 10.1007/s12194-013-0243-0

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: The aim of this study was to evaluate the usefulness of noise reduction procedure (NRP), a function in the new image processing for chest radiography. METHODS: A CXDI-50G Portable Digital Radiography System (Canon) was used for X-ray detection. Image noise was analyzed with a noise power spectrum (NPS) and a burger phantom was used for evaluation of density resolution. The usefulness of NRP was evaluated by chest phantom images and clinical chest radiography. We employed the Bureau of Radiological Health Method for scoring chest images while carrying out our observations. RESULTS: NPS through the use of NRP was improved compared with conventional image processing (CIP). The results in image quality showed high-density resolution through the use of NRP, so that chest radiography examination can be performed with a low dose of radiation. Scores were significantly higher than for CIP. CONCLUSION: In this study, use of NRP led to a high evaluation in these so we are able to confirm the usefulness of NRP for clinical chest radiography.

PubMed

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担当区分：筆頭著者   記述言語：日本語   掲載種別：講演資料等（セミナー，チュートリアル，講習，講義他）  

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）  

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担当区分：最終著者   記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）  

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記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）  

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担当区分：最終著者   記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）  

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記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）  

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）  

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担当区分：最終著者   記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）  

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記述言語：日本語   会議種別：口頭発表（一般）  

添付ファイル： 演題13_JSNM中四国支部会_oral_fukui.pdf

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記述言語：日本語   会議種別：口頭発表（一般）  

添付ファイル： 山デジ_PETtoCT_福井.pdf

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記述言語：日本語   会議種別：口頭発表（一般）  

添付ファイル： MII2020_poster.pdf

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記述言語：英語   会議種別：口頭発表（一般）  

添付ファイル： RSNA2019_educational exhibit_1019.pdf

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記述言語：日本語   会議種別：口頭発表（一般）  

添付ファイル： JSRT_Autumn2019_oral.pdf

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記述言語：日本語   会議種別：口頭発表（一般）  

添付ファイル： CSFRT2019_oral.pdf

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記述言語：日本語   会議種別：口頭発表（招待・特別）  

添付ファイル： 第25回サマースクール_AI.pdf

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記述言語：日本語   会議種別：口頭発表（一般）  

添付ファイル： 令和1年度夏季_核医学_症例報告0706.pdf

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記述言語：日本語   会議種別：口頭発表（一般）  

添付ファイル： JRC2019_Cypos_0227.pdf

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記述言語：日本語   会議種別：口頭発表（一般）  

添付ファイル： JRC2019_Cypos_last.pdf

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記述言語：日本語   会議種別：口頭発表（一般）  

添付ファイル： JRC2019_Cypos_20190222.pdf

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