Updated on 2026/06/17

写真a

 
Ding Xue
 
Organization
Faculty of Interdisciplinary Science and Engineering in Health Systems Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
External link

Research Interests

  • sensors

  • cancer cell

  • Terahertz

Education

  • Okayama University     ヘルスシステム統合科学研究科

    2021.4

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    Country： Japan

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Papers

  • Highly sensitive detection of cancer cells using a voltage-tuned terahertz chemical microscope

    Xue Ding, Yuto Ohmi, Jin Wang, Hirofumi Inoue, Toshihiko Kiwa

    SENSING AND BIO-SENSING RESEARCH   51   2026.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.sbsr.2026.100972

    Web of Science

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  • A small molecule esculetin accelerates postprandial lipid clearance involving activation of C/EBPβ and CD36-mediated phagocytosis by adipose tissue macrophages. International journal

    Gang Wang, Zhaokai Li, Wei Ni, Heng Ye, Yang Liu, Linjian Chen, Lin Wang, Changjiang Liu, Jingyu Chen, Xuchao Wang, Xue Ding, Longshan Zhao, Xiaofeng Ge, Yan Wang, Yuanchao Ye, Toshihiko Kiwa, Linghe Zang, Jin Wang, Cuilian Dai, Binbin Liu

    Theranostics   15 ( 12 )   5910 - 5930   2025

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    Language：English   Publishing type：Research paper (scientific journal)  

    Rationale: Adipose tissue buffers dietary lipids to maintain postprandial lipid homeostasis. Adipose tissue macrophages (ATMs) mediate the phagocytosis of postprandial lipids from the exogenous diet, generating high-density lipoprotein (HDL) particles that facilitate lipid circulation and excretion. However, the underlying mechanisms remain poorly understood. This study investigates the effects of esculetin, a coumarin compound, on postprandial cholesterol circulation and excretion following a high-fat meal. Methods: Mice were fed a lipid-rich meal for three days to assess the effects of esculetin on postprandial lipid circulation, using serum lipid profiling and metabolomics analysis. Epididymal white adipose tissue (eWAT) removal and flow cytometry were performed to analyze ATMs and confirm their role in mediating esculetin's effects on postprandial lipemia. Epigenetic profiling, transcriptome analysis, chromatin immunoprecipitation, and Terahertz chemical microscopy were employed to elucidate the molecular targets and mechanisms of esculetin. Results: Esculetin significantly elevates postprandial HDL cholesterol levels to values comparable to pitavastatin and modifies serum metabolites involved in bile-mediated cholesterol excretion, leading to increased bile acid concentrations in the bile. This effect is mediated by an increased ratio and phagocytic activity of a subset of ATMs expressing the scavenger receptor CD36, as eWAT removal and CD36 blockade inhibit this response. Furthermore, esculetin enhances the uptake of oxidized LDL via CD36, as demonstrated in cultured macrophages, and induces epigenetic changes controlled by the key transcription factor C/EBPβ, accompanied by increased C/EBPβ binding to the Cd36 promoter. A direct interaction between esculetin and C/EBPβ was observed using Terahertz chemical microscopy. Additionally, the activation of C/EBPβ by esculetin in ATMs was confirmed in vivo. Conclusion: Esculetin accelerates postprandial lipid circulation by binding to C/EBPβ and enhancing CD36-dependent phagocytosis in ATMs.

    DOI： 10.7150/thno.110207

    PubMed

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  • Microdetection of Nucleocapsid Proteins via Terahertz Chemical Microscope Using Aptamers Reviewed

    Xue Ding, Mana Murakami, Jin Wang, Hirofumi Inoue, Toshihiko Kiwa

    sensors   2024.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    File： sensors-24-07382 (1).pdf

    DOI： 10.3390/s24227382

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  • Voltage-Controlled Terahertz Chemical Microscope for High-Sensitive Measurement of Biological Materials

    Xue Ding, Mana Murakami, Jin Wang, Hirofumi Inoue, Toshihiko Kiwa

    2024.8

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    Authorship：Lead author   Publishing type：Research paper (international conference proceedings)  

    DOI： 10.1109/CLEO-PR60912.2024.10676771

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  • Detection of nucleocapsid proteins of COVID-19 using a terahertz chemical microscope Reviewed

    2023.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (international conference proceedings)  

    DOI： 10.1109/IRMMW-THz57677.2023.10298956

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  • Development of Lung Cancer Cell Detection Technology in Liquid Phase Using a Terahertz Chemical Microscope

    DING XUE, Tsuji Sayaka, Yoshida Yuichi, Iwatsuki Kohei, Inoue Hirofumi, Wang Jin, Sakai Kenji, Kiwa Toshihiko

    JSAP Annual Meetings Extended Abstracts   2022.1   858 - 858   2022.2

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    Language：Japanese   Publisher：The Japan Society of Applied Physics  

    DOI： 10.11470/jsapmeeting.2022.1.0_858

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  • Detection of lung cancer cells in solutions using a terahertz chemical microscope Reviewed

    Yoshida, Y, Ding, X, Iwatsuki, K, Taniizumi, K, Inoue, H, Wang, J, Sakai, K, Kiwa, T

    sensors   21 ( 22 )   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    File： sensors-21-07631-v2.pdf

    DOI： 10.3390/s21227631

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MISC

  • Biosensing by a Terahertz Chemical Microscopy

    紀和利彦, DING Xue, 村上真菜, 劉長江, 井上博文, WANG Jin

    電気学会全国大会講演論文集(CD-ROM)   2025   2025

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  • Development of Voltage-Controlled Terahertz Chemical Microscope for The High-Sensitive Detection of Lung Adenocarcinoma Cells

    村上真菜, DING Xue, 辻紗也佳, WANG Jin, 井上博文, 紀和利彦

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   71st   2024

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  • Lung Adenocarcinoma Cells Detection by Voltage-Applied Terahertz Chemical Microscope

    村上真菜, 辻紗也佳, DING Xue, WANG Jin, 井上博文, 紀和利彦

    電気・情報関連学会中国支部連合大会講演論文集(CD-ROM)   74th   2023

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  • Sensitivity Improvement of TCM by Voltage Modulation of Depletion Layer

    村上真菜, 辻紗也佳, DING Xue, WANG Jin, 井上博文, 紀和利彦

    応用物理・物理系学会中国四国支部合同学術講演会講演予稿集(CD-ROM)   2023   2023

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  • Development of SARS-CoV-2 detection technology by aptamers using a terahertz chemical microscope

    辻紗也佳, DING Xue, 村上真菜, 井上博文, WANG Jin, 堺健司, 紀和利彦

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   70th   2023

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  • Application of a terahertz chemical microscope

    紀和利彦, 葭田勇一, DING Xue, 辻紗也佳, 岩附康平, 谷泉克弥, WANG Jin, 堺健司, 井上博文

    日本化学会春季年会講演予稿集(Web)   102nd   2022

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Presentations

  • Sensitivity-Controlled Measurement of Cancer Cells Using Terahertz Chemical Microscopy

    Xue Ding, Mana Murakami, Jin Wang, Hirofumi Inoue, Toshihiko Kiwa

    Opto-X-Nano  2024.11.27 

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    Event date： 2024.11.27 - 2024.11.29

    Language：English   Presentation type：Poster presentation  

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  • Detection of Biological Materials by A Versatile Terahertz Chemical Microscope

    Xue Ding, Mana Murakami, Jin Wang, Hirofumi Inoue, Toshihiko Kiwa

    Opto-X-Nano  2024.11.28 

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    Event date： 2024.10.27 - 2024.11.29

    Language：English   Presentation type：Oral presentation (invited, special)  

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  • Voltage-Controlled Terahertz Chemical Microscope for High-Sensitive Measurement of Biological Materials

    Xue Ding, Mana Murakami, Jin Wang, Hirofumi Inoue, Toshihiko Kiwa

    the 16th Pacific Rim Conference on Lasers and Electro-Optics (CLEO-PR 2024)  2024.8.7 

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    Event date： 2024.8.4 - 2024.8.9

    Language：English   Presentation type：Oral presentation (general)  

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  • Detection of Lung Cancer Cells by A Voltage-controlled Terahertz Chemical Microscopy

    DING XUE

    the 6th International Symposium on Microwave/THz Science and Applications (MTSA2024) 

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    Event date： 2024.6.3 - 2024.6.7

    Language：English   Presentation type：Poster presentation  

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  • Microdetection of Nucleocapsid Proteins by Terahertz Chemical Microscopy

    DING XUE

    2024.3.25 

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    Event date： 2024.3.22 - 2024.3.25

    Language：English  

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  • High-sensitive detection of nucleocapsid proteins of COVID-19 using a terahertz chemical microscope

    DING XUE

    2023.12.18 

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    Event date： 2023.12.18 - 2023.12.19

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Detection of Nucleocapsid Proteins of COVID-19 using a Terahertz Chemical Microscope

    DING XUE

    The 48th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz 2023) 

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    Event date： 2023.9.17 - 2023.9.22

    Language：English   Presentation type：Oral presentation (general)  

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  • Development of Lung Cancer Cell Detection Technology in Liquid Phase

    DING XUE

    2022.3.26 

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    Event date： 2022.3.22 - 2022.3.26

    Language：Japanese   Presentation type：Oral presentation (general)  

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